                         SEQUENCE LISTING

<110>  Scribe Therapeutics Inc.
 
<120>  COMPOSITIONS AND METHODS FOR THE TARGETING OF PCSK9

<130>  SCRB-017/01WO 333322-2110

<150>  US 62/959,685
<151>  2020-01-10

<160>  13864 

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Unknown

<220>  
<223>  Deltaproteobacteria sp.

<400>  1

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr 
            820                 825                 830         


Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly 
        835                 840                 845             


Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser 
865                 870                 875                 880 


Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser 
                885                 890                 895     


Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys 
        915                 920                 925             


Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  2
<211>  978
<212>  PRT
<213>  Unknown

<220>  
<223>  Planctomycetes sp.

<400>  2

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3
<211>  855
<212>  PRT
<213>  Unknown

<220>  
<223>  Candidatus Sungbacteria sp.

<400>  3

Met Asp Asn Ala Asn Lys Pro Ser Thr Lys Ser Leu Val Asn Thr Thr 
1               5                   10                  15      


Arg Ile Ser Asp His Phe Gly Val Thr Pro Gly Gln Val Thr Arg Val 
            20                  25                  30          


Phe Ser Phe Gly Ile Ile Pro Thr Lys Arg Gln Tyr Ala Ile Ile Glu 
        35                  40                  45              


Arg Trp Phe Ala Ala Val Glu Ala Ala Arg Glu Arg Leu Tyr Gly Met 
    50                  55                  60                  


Leu Tyr Ala His Phe Gln Glu Asn Pro Pro Ala Tyr Leu Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Tyr Glu Thr Phe Phe Lys Gly Arg Pro Val Leu Asn Gly Leu 
                85                  90                  95      


Arg Asp Ile Asp Pro Thr Ile Met Thr Ser Ala Val Phe Thr Ala Leu 
            100                 105                 110         


Arg His Lys Ala Glu Gly Ala Met Ala Ala Phe His Thr Asn His Arg 
        115                 120                 125             


Arg Leu Phe Glu Glu Ala Arg Lys Lys Met Arg Glu Tyr Ala Glu Cys 
    130                 135                 140                 


Leu Lys Ala Asn Glu Ala Leu Leu Arg Gly Ala Ala Asp Ile Asp Trp 
145                 150                 155                 160 


Asp Lys Ile Val Asn Ala Leu Arg Thr Arg Leu Asn Thr Cys Leu Ala 
                165                 170                 175     


Pro Glu Tyr Asp Ala Val Ile Ala Asp Phe Gly Ala Leu Cys Ala Phe 
            180                 185                 190         


Arg Ala Leu Ile Ala Glu Thr Asn Ala Leu Lys Gly Ala Tyr Asn His 
        195                 200                 205             


Ala Leu Asn Gln Met Leu Pro Ala Leu Val Lys Val Asp Glu Pro Glu 
    210                 215                 220                 


Glu Ala Glu Glu Ser Pro Arg Leu Arg Phe Phe Asn Gly Arg Ile Asn 
225                 230                 235                 240 


Asp Leu Pro Lys Phe Pro Val Ala Glu Arg Glu Thr Pro Pro Asp Thr 
                245                 250                 255     


Glu Thr Ile Ile Arg Gln Leu Glu Asp Met Ala Arg Val Ile Pro Asp 
            260                 265                 270         


Thr Ala Glu Ile Leu Gly Tyr Ile His Arg Ile Arg His Lys Ala Ala 
        275                 280                 285             


Arg Arg Lys Pro Gly Ser Ala Val Pro Leu Pro Gln Arg Val Ala Leu 
    290                 295                 300                 


Tyr Cys Ala Ile Arg Met Glu Arg Asn Pro Glu Glu Asp Pro Ser Thr 
305                 310                 315                 320 


Val Ala Gly His Phe Leu Gly Glu Ile Asp Arg Val Cys Glu Lys Arg 
                325                 330                 335     


Arg Gln Gly Leu Val Arg Thr Pro Phe Asp Ser Gln Ile Arg Ala Arg 
            340                 345                 350         


Tyr Met Asp Ile Ile Ser Phe Arg Ala Thr Leu Ala His Pro Asp Arg 
        355                 360                 365             


Trp Thr Glu Ile Gln Phe Leu Arg Ser Asn Ala Ala Ser Arg Arg Val 
    370                 375                 380                 


Arg Ala Glu Thr Ile Ser Ala Pro Phe Glu Gly Phe Ser Trp Thr Ser 
385                 390                 395                 400 


Asn Arg Thr Asn Pro Ala Pro Gln Tyr Gly Met Ala Leu Ala Lys Asp 
                405                 410                 415     


Ala Asn Ala Pro Ala Asp Ala Pro Glu Leu Cys Ile Cys Leu Ser Pro 
            420                 425                 430         


Ser Ser Ala Ala Phe Ser Val Arg Glu Lys Gly Gly Asp Leu Ile Tyr 
        435                 440                 445             


Met Arg Pro Thr Gly Gly Arg Arg Gly Lys Asp Asn Pro Gly Lys Glu 
    450                 455                 460                 


Ile Thr Trp Val Pro Gly Ser Phe Asp Glu Tyr Pro Ala Ser Gly Val 
465                 470                 475                 480 


Ala Leu Lys Leu Arg Leu Tyr Phe Gly Arg Ser Gln Ala Arg Arg Met 
                485                 490                 495     


Leu Thr Asn Lys Thr Trp Gly Leu Leu Ser Asp Asn Pro Arg Val Phe 
            500                 505                 510         


Ala Ala Asn Ala Glu Leu Val Gly Lys Lys Arg Asn Pro Gln Asp Arg 
        515                 520                 525             


Trp Lys Leu Phe Phe His Met Val Ile Ser Gly Pro Pro Pro Val Glu 
    530                 535                 540                 


Tyr Leu Asp Phe Ser Ser Asp Val Arg Ser Arg Ala Arg Thr Val Ile 
545                 550                 555                 560 


Gly Ile Asn Arg Gly Glu Val Asn Pro Leu Ala Tyr Ala Val Val Ser 
                565                 570                 575     


Val Glu Asp Gly Gln Val Leu Glu Glu Gly Leu Leu Gly Lys Lys Glu 
            580                 585                 590         


Tyr Ile Asp Gln Leu Ile Glu Thr Arg Arg Arg Ile Ser Glu Tyr Gln 
        595                 600                 605             


Ser Arg Glu Gln Thr Pro Pro Arg Asp Leu Arg Gln Arg Val Arg His 
    610                 615                 620                 


Leu Gln Asp Thr Val Leu Gly Ser Ala Arg Ala Lys Ile His Ser Leu 
625                 630                 635                 640 


Ile Ala Phe Trp Lys Gly Ile Leu Ala Ile Glu Arg Leu Asp Asp Gln 
                645                 650                 655     


Phe His Gly Arg Glu Gln Lys Ile Ile Pro Lys Lys Thr Tyr Leu Ala 
            660                 665                 670         


Asn Lys Thr Gly Phe Met Asn Ala Leu Ser Phe Ser Gly Ala Val Arg 
        675                 680                 685             


Val Asp Lys Lys Gly Asn Pro Trp Gly Gly Met Ile Glu Ile Tyr Pro 
    690                 695                 700                 


Gly Gly Ile Ser Arg Thr Cys Thr Gln Cys Gly Thr Val Trp Leu Ala 
705                 710                 715                 720 


Arg Arg Pro Lys Asn Pro Gly His Arg Asp Ala Met Val Val Ile Pro 
                725                 730                 735     


Asp Ile Val Asp Asp Ala Ala Ala Thr Gly Phe Asp Asn Val Asp Cys 
            740                 745                 750         


Asp Ala Gly Thr Val Asp Tyr Gly Glu Leu Phe Thr Leu Ser Arg Glu 
        755                 760                 765             


Trp Val Arg Leu Thr Pro Arg Tyr Ser Arg Val Met Arg Gly Thr Leu 
    770                 775                 780                 


Gly Asp Leu Glu Arg Ala Ile Arg Gln Gly Asp Asp Arg Lys Ser Arg 
785                 790                 795                 800 


Gln Met Leu Glu Leu Ala Leu Glu Pro Gln Pro Gln Trp Gly Gln Phe 
                805                 810                 815     


Phe Cys His Arg Cys Gly Phe Asn Gly Gln Ser Asp Val Leu Ala Ala 
            820                 825                 830         


Thr Asn Leu Ala Arg Arg Ala Ile Ser Leu Ile Arg Arg Leu Pro Asp 
        835                 840                 845             


Thr Asp Thr Pro Pro Thr Pro 
    850                 855 


<210>  4
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  4
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag agaaaccgau aaguaaaacg caucaaag                   108


<210>  5
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  5
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  6
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  6
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag a                                                 81


<210>  7
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  7
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucgg                                                     78


<210>  8
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  8
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga                                                   80


<210>  9
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  9
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgg                                                      77


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  10
guuuacacac ucccucucau agggu                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  11
guuuacacac ucccucucau gaggu                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  12
uuuuacauac ccccucucau gggau                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  13
guuuacacac ucccucucau ggggg                                             25


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  14
ccagcgacua ugucguaugg                                                   20


<210>  15
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  15
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  16
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gRNA sequence

<400>  16
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cgga                                                         74


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer target sequence

<400>  17
tgtggtcggg gtagcggctg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer target sequence

<400>  18
tcaagtccgc catgcccgaa                                                   20


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(18)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  These individual nucleotides may be absent

<400>  19
uuunnnnnnn nnnnnnnnuu u                                                 21


<210>  20
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold stem loop

<400>  20
ccagcgacua ugucguaugg                                                   20


<210>  21
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  extended stem loop

<400>  21
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  22
<211>  81
<212>  RNA
<213>  Unknown

<220>  
<223>  Deltaproteobacter sp.

<400>  22
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag a                                                 81


<210>  23
<211>  78
<212>  RNA
<213>  Unknown

<220>  
<223>  Deltaproteobacter sp.

<400>  23
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucgg                                                     78


<210>  24
<211>  23
<212>  RNA
<213>  Unknown

<220>  
<223>  Deltaproteobacter sp.

<400>  24
ccgauaagua aaacgcauca aag                                               23


<210>  25
<211>  2413
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pStx42.174.27.5 plasmid sequence

<400>  25
ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt       60

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta      120

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg      180

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac      240

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg      300

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc      360

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg      420

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat      480

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg      540

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg      600

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc      660

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt      720

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct      780

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc      840

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca      900

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct      960

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt     1020

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     1080

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     1140

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     1200

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     1260

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag     1320

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     1380

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     1440

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     1500

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     1560

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     1620

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     1680

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     1740

acgccagcaa cgcggccttt ttacggttcc cgacaggccc gaaggaatag aagaagaagg     1800

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcct     1860

ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag     1920

caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg     1980

tttattacag ggacagcaga gatccagttt gagggcctat ttcccatgat tccttcatat     2040

ttgcatatac gatacaaggc tgttagagag ataattggaa ttaatttgac tgtaaacaca     2100

aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta gtttgcagtt     2160

ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa gtatttcgat     2220

ttcttggctt tatatatctt gtggaaagga cgaaacacca ctggcgcttt tatctgatta     2280

ctttgagagc catcaccagc gactatgtcg tagtgggtaa agctccctct tcggagggag     2340

catcaaagga ggctagagga ctgagccatt ttttttgaat tcgctagcta ggtctagacg     2400

tcaggtggca ctt                                                        2413


<210>  26
<211>  2413
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pStx42.174.6.8 plasmid sequence

<400>  26
ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt       60

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta      120

tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg      180

tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac      240

gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg      300

aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc      360

gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg      420

ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat      480

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg      540

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg      600

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc      660

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt      720

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct      780

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc      840

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca      900

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct      960

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt     1020

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     1080

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     1140

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     1200

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     1260

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag     1320

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     1380

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     1440

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     1500

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     1560

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     1620

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     1680

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     1740

acgccagcaa cgcggccttt ttacggttcc cgacaggccc gaaggaatag aagaagaagg     1800

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcct     1860

ttaaaagaaa aggggggatt ggggggtaca gtgcagggga aagaatagta gacataatag     1920

caacagacat acaaactaaa gaattacaaa aacaaattac aaaaattcaa aattttcggg     1980

tttattacag ggacagcaga gatccagttt gagggcctat ttcccatgat tccttcatat     2040

ttgcatatac gatacaaggc tgttagagag ataattggaa ttaatttgac tgtaaacaca     2100

aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta gtttgcagtt     2160

ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa gtatttcgat     2220

ttcttggctt tatatatctt gtggaaagga cgaaacacca ctggcgcttt tatctgatta     2280

ctttgagagc catcaccagc gactatgtcg tagtgggtaa agctccctct tcggagggag     2340

catcaaagtg gcttcctggt gaagatgatt ttttttgaat tcgctagcta ggtctagacg     2400

tcaggtggca ctt                                                        2413


<210>  27
<211>  26
<212>  RNA
<213>  Unknown

<220>  
<223>  Planctomycetes sp.

<400>  27
ucuccgauaa auaagaagca ucaaag                                            26


<210>  28
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pGP2 plasmid sequence

<400>  28
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aagtaa                               1536


<210>  29
<211>  9280
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP0017 plasmid sequence

<400>  29
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc gccgcccgcc      720

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      780

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      840

ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc ggccgggggc     1020

ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1080

tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc     1140

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc ggggcgtggc     1200

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1260

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gccccggagc gccggcggct     1320

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1380

gacttccttt gtcccaaatc tggcggagcc gaaatctggg aggcgccgcc gcaccccctc     1440

tagcgggcgc gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc catctccagc ctcggggctg ccgcaggggg     1560

acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg     1620

gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca     1680

acgtgctggt tgttgtgctg tctcatcatt ttggcaaaga attcgccacc atgggtgcga     1740

gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg ttaaggccag     1800

ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag ctagaacgat     1860

tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata ctgggacagc     1920

tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat acagtagcaa     1980

ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct ttagacaaga     2040

tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct gacacaggac     2100

acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg caaatggtac     2160

atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa gagaaggctt     2220

tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc ccacaagatt     2280

taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg ttaaaagaga     2340

ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca gggcctattg     2400

caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact agtacccttc     2460

aggaacaaat aggatggatg acacataatc cacctatccc agtaggagaa atctataaaa     2520

gatggataat cctgggatta aataaaatag taagaatgta tagccctacc agcattctgg     2580

acataagaca aggaccaaag gaacccttta gagactatgt agaccgattc tataaaactc     2640

taagagccga gcaagcttca caagaggtaa aaaattggat gacagaaacc ttgttggtcc     2700

aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagga gcgacactag     2760

aagaaatgat gacagcatgt cagggagtgg ggggacccgg ccataaagca agagttttgg     2820

ctgaagcaat gagccaagta acaaatccag ctaccataat gatacagaaa ggcaatttta     2880

ggaaccaaag aaagactgtt aagtgtttca attgtggcaa agaagggcac atagccaaaa     2940

attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga caccaaatga     3000

aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc cacaagggaa     3060

ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa gagagcttca     3120

ggtttgggga agagacaaca actccctctc agaagcagga gccgatagac aaggaactgt     3180

atcctttagc ttccctcaga tcactctttg gcagcgaccc ctcgtcacaa aactttagcc     3240

agaactatcc gattgtgcag accggtgccc caaagaagaa gcggaaggtc tctagacaag     3300

agatcaagag aatcaacaag atcagaagga gactggtcaa ggacagcaac acaaagaagg     3360

ccggcaagac aggccccatg aaaaccctgc tcgtcagagt gatgacccct gacctgagag     3420

agcggctgga aaacctgaga aagaagcccg agaacatccc tcagcctatc agcaacacca     3480

gcagggccaa cctgaacaag ctgctgaccg actacaccga gatgaagaaa gccatcctgc     3540

acgtgtactg ggaagagttc cagaaagacc ccgtgggcct gatgagcaga gttgctcagc     3600

ctgccagcaa gaagatcgac cagaacaagc tgaagcccga gatggacgag aagggcaatc     3660

tgaccacagc cggctttgcc tgctctcagt gtggccagcc tctgttcgtg tacaagctgg     3720

aacaggtgtc cgagaaaggc aaggcctaca ccaactactt cggcagatgt aacgtggccg     3780

agcacgagaa gctgattctg ctggcccagc tgaaacctga gaaggactct gatgaggccg     3840

tgacctacag cctgggcaag tttggacaga gagccctgga cttctacagc atccacgtga     3900

ccaaagaaag cacacacccc gtgaagcccc tggctcagat cgccggcaat agatacgcct     3960

ctggacctgt gggcaaagcc ctgtccgatg cctgcatggg aacaatcgcc agcttcctga     4020

gcaagtacca ggacatcatc atcgagcacc agaaggtggt caagggcaac cagaagagac     4080

tggaaagcct gagggagctg gccggcaaag agaacctgga ataccccagc gtgaccctgc     4140

ctcctcagcc tcacacaaaa gaaggcgtgg acgcctacaa cgaagtgatc gccagagtga     4200

gaatgtgggt caacctgaac ctgtggcaga agctgaaact gtccagggac gacgccaagc     4260

ctctgctgag actgaagggc ttccctagct tccctctggt ggaaagacag gccaatgaag     4320

tggattggtg ggacatggtc tgcaacgtga agaagctgat caacgagaag aaagaggatg     4380

gcaaggtttt ctggcagaac ctggccggct acaagagaca agaagccctg aggccttacc     4440

tgagcagcga agaggaccgg aagaagggca agaagttcgc cagataccag ctgggcgacc     4500

tgctgctgca cctggaaaag aagcacggcg aggactgggg caaagtgtac gatgaggcct     4560

gggagagaat cgacaagaag gtggaaggcc tgagcaagca cattaagctg gaagaggaaa     4620

gaaggagcga ggacgcccaa tctaaagccg ctctgaccga ttggctgaga gccaaggcca     4680

gctttgtgat cgagggcctg aaagaggccg acaaggacga gttctgcaga tgcgagctga     4740

agctgcagaa gtggtacggc gatctgagag gcaagccctt cgccattgag gccgagaaca     4800

gcatcctgga catcagcggc ttcagcaagc agtacaactg cgccttcatt tggcagaaag     4860

acggcgtcaa gaaactgaac ctgtacctga tcatcaatta cttcaaaggc ggcaagctgc     4920

ggttcaagaa gatcaaaccc gaggccttcg aggctaacag attctacacc gtgatcaaca     4980

aaaagtccgg cgagatcgtg cccatggaag tgaacttcaa cttcgacgac cccaacctga     5040

ttatcctgcc tctggccttc ggcaagagac agggcagaga gttcatctgg aacgatctgc     5100

tgagcctgga aaccggctct ctgaagctgg ccaatggcag agtgatcgag aaaaccctgt     5160

acaacaggag aaccagacag gacgagcctg ctctgtttgt ggccctgacc ttcgagagaa     5220

gagaggtgct ggacagcagc aacatcaagc ccatgaacct gatcggcgtg gaccggggcg     5280

agaatatccc tgctgtgatc gccctgacag accctgaagg atgcccactg agcagattca     5340

aggactccct gggcaaccct acacacatcc tgagaatcgg cgagagctac aaagagaagc     5400

agaggacaat ccaggccaag aaagaggtgg aacagagaag agccggcgga tactctagga     5460

agtacgccag caaggccaag aatctggccg acgacatggt ccgaaacacc gccagagatc     5520

tgctgtacta cgccgtgaca caggacgcca tgctgatctt cgagaatctg agcagaggct     5580

tcggccggca gggcaagaga acctttatgg ccgagaggca gtacaccaga atggaagatt     5640

ggctcacagc taaactggcc tacgagggac tgagcaagac ctacctgtcc aaaacactgg     5700

cccagtatac ctccaagacc tgcagcaatt gcggcttcac catcaccagc gccgactacg     5760

acagagtgct ggaaaagctc aagaaaaccg ccaccggctg gatgaccacc atcaacggca     5820

aagagctgaa ggttgagggc cagatcacct actacaacag gtacaagagg cagaacgtcg     5880

tgaaggatct gagcgtggaa ctggacagac tgagcgaaga gagcgtgaac aacgacatca     5940

gcagctggac aaagggcaga tcaggcgagg ctctgagcct gctgaagaag aggtttagcc     6000

acagacctgt gcaagagaag ttcgtgtgcc tgaactgcgg cttcgagaca cacgccgatg     6060

aacaggctgc cctgaacatt gccagaagct ggctgttcct gagaagccaa gagtacaaga     6120

agtaccagac caacaagacc accggcaaca ccgacaagag ggcctttgtg gaaacctggc     6180

agagcttcta cagaaaaaag ctgaaagaag tctggaagcc cgccgtgact agtccaaaaa     6240

agaagagaaa ggtagccctc gagtacccat atgatgtccc tgactacgct tgactagcag     6300

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     6360

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     6420

cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag tatttggttt     6480

agagtttggc aacatatgcc catatgctgg ctgccatgaa caaaggttgg ctataaagag     6540

gtcatcagta tatgaaacag ccccctgctg tccattcctt attccataga aaagccttga     6600

cttgaggtta gatttttttt atattttgtt ttgtgttatt tttttcttta acatccctaa     6660

aattttcctt acatgtttta ctagccagat ttttcctcct ctcctgacta ctcccagtca     6720

tagctgtccc tcttctctta tgaagatccc tcgacctgca gcccaagctt ggcgtaatca     6780

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     6840

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     6900

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagcg gatccgcatc     6960

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc     7020

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg     7080

aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag     7140

gcttttgcaa aaagctaact tgtttattgc agcttataat ggttacaaat aaagcaatag     7200

catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa     7260

actcatcaat gtatcttatc atgtctggat ccgctgcatt aatgaatcgg ccaacgcgcg     7320

gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc     7380

tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc     7440

acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg     7500

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     7560

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     7620

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     7680

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg     7740

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     7800

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     7860

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     7920

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt     7980

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     8040

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     8100

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     8160

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     8220

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     8280

tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt     8340

tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca     8400

tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca     8460

gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc     8520

tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt     8580

ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg     8640

gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc     8700

aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg     8760

ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga     8820

tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga     8880

ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta     8940

aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg     9000

ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact     9060

ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata     9120

agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt     9180

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     9240

ataggggttc cgcgcacatt tccccgaaaa gtgccacctg                           9280


<210>  30
<211>  10690
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pXDP0001 plasmid sequence

<400>  30
ggagtcgctg cgcgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg       60

ccccggctct gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct      120

ccgggctgta attagcgctt ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa      180

agccttgagg ggctccggga gggccctttg tgcgggggga gcggctcggg gggtgcgtgc      240

gtgtgtgtgt gcgtggggag cgccgcgtgc ggctccgcgc tgcccggcgg ctgtgagcgc      300

tgcgggcgcg gcgcggggct ttgtgcgctc cgcagtgtgc gcgaggggag cgcggccggg      360

ggcggtgccc cgcggtgcgg ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg      420

tgcgtggggg ggtgagcagg gggtgtgggc gcgtcggtcg ggctgcaacc ccccctgcac      480

ccccctcccc gagttgctga gcacggcccg gcttcgggtg cggggctccg tacggggcgt      540

ggcgcggggc tcgccgtgcc gggcgggggg tggcggcagg tgggggtgcc gggcggggcg      600

gggccgcctc gggccgggga gggctcgggg gaggggcgcg gcggcccccg gagcgccggc      660

ggctgtcgag gcgcggcgag ccgcagccat tgccttttat ggtaatcgtg cgagagggcg      720

cagggacttc ctttgtccca aatctgtgcg gagccgaaat ctgggaggcg ccgccgcacc      780

ccctctagcg ggcgcggggc gaagcggtgc ggcgccggca ggaaggaaat gggcggggag      840

ggccttcgtg cgtcgccgcg ccgccgtccc cttctccctc tccagcctcg gggctgtccg      900

cggggggacg gctgccttcg ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg      960

accggcggct ctagagcctc tgctaaccat gttcatgcct tcttcttttt cctacagctc     1020

ctgggcaacg tgctggttat tgtgctgtct catcattttg gcaaagaatt cgggccgcgt     1080

tgacgcgcac ggcaagaggc gaggggcggc gactggtgag agatgggtgc gagagcgtca     1140

gtattaagcg ggggagaatt agatcgatgg gaaaaaattc ggttaaggcc agggggaaag     1200

aaaaaatata aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt     1260

aatcctggcc tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca     1320

tcccttcaga caggatcaga agaacttaga tcattatata atacagtagc aaccctctat     1380

tgtgtgcatc aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa     1440

gagcaaaaca aaagtaagaa aaaagcacag caagcagcag ctgacacagg acacagcaat     1500

caggtcagcc aaaattaccc tatagtgcag aacatccagg ggcaaatggt acatcaggcc     1560

atatcaccta gaactttaaa tgcatgggta aaagtagtag aagagaaggc tttcagccca     1620

gaagtgatac ccatgttttc agcattatca gaaggagcca ccccacaaga tttaaacacc     1680

atgctaaaca cagtgggggg acatcaagca gccatgcaaa tgttaaaaga gaccatcaat     1740

gaggaagctg cagaatggga tagagtgcat ccagtgcatg cagggcctat tgcaccaggc     1800

cagatgagag aaccaagggg aagtgacata gcaggaacta ctagtaccct tcaggaacaa     1860

ataggatgga tgacacataa tccacctatc ccagtaggag aaatctataa aagatggata     1920

atcctgggat taaataaaat agtaagaatg tatagcccta ccagcattct ggacataaga     1980

caaggaccaa aggaaccctt tagagactat gtagaccgat tctataaaac tctaagagcc     2040

gagcaagctt cacaagaggt aaaaaattgg atgacagaaa ccttgttggt ccaaaatgcg     2100

aacccagatt gtaagactat tttaaaagca ttgggaccag gagcgacact agaagaaatg     2160

atgacagcat gtcagggagt ggggggaccc ggccataaag caagagtttt ggctgaagca     2220

atgagccaag taacaaatcc agctaccata atgatacaga aaggcaattt taggaaccaa     2280

agaaagactg ttaagtgttt caattgtggc aaagaagggc acatagccaa aaattgcagg     2340

gcccctagga aaaagggctg ttggaaatgt ggaaaggaag gacaccaaat gaaagattgt     2400

actgagagac aggctaattt tttagggaag atctggcctt cccacaaggg aaggccaggg     2460

aattttcttc agagcagacc agagccaaca gccccaccag aagagagctt caggtttggg     2520

gaagagacaa caactccctc tcagaagcag gagccgatag acaaggaact gtatccttta     2580

gcttccctca gatcactctt tggcagcgac ccctcgtcac aataaagata ggggggcaat     2640

taaaggaagc tctattagat acaggagcag atgatacagt attagaagaa atgaatttgc     2700

caggaagatg gaaaccaaaa atgatagggg gaattggagg ttttatcaaa gtaagacagt     2760

atgatcagat actcatagaa atctgcggac ataaagctat aggtacagta ttagtaggac     2820

ctacacctgt caacataatt ggaagaaatc tgttgactca gattggctgc actttaaatt     2880

ttcccattag tcctattgag actgtaccag taaaattaaa gccaggaatg gatggcccaa     2940

aagttaaaca atggccattg acagaagaaa aaataaaagc attagtagaa atttgtacag     3000

aaatggaaaa ggaaggaaaa atttcaaaaa ttgggcctga aaatccatac aatactccag     3060

tatttgccat aaagaaaaaa gacagtacta aatggagaaa attagtagat ttcagagaac     3120

ttaataagag aactcaagat ttctgggaag ttcaattagg aataccacat cctgcagggt     3180

taaaacagaa aaaatcagta acagtactgg atgtgggcga tgcatatttt tcagttccct     3240

tagataaaga cttcaggaag tatactgcat ttaccatacc tagtataaac aatgagacac     3300

cagggattag atatcagtac aatgtgcttc cacagggatg gaaaggatca ccagcaatat     3360

tccagtgtag catgacaaaa atcttagagc cttttagaaa acaaaatcca gacatagtca     3420

tctatcaata catggatgat ttgtatgtag gatctgactt agaaataggg cagcatagaa     3480

caaaaataga ggaactgaga caacatctgt tgaggtgggg atttaccaca ccagacaaaa     3540

aacatcagaa agaacctcca ttcctttgga tgggttatga actccatcct gataaatgga     3600

cagtacagcc tatagtgctg ccagaaaagg acagctggac tgtcaatgac atacagaaat     3660

tagtgggaaa attgaattgg gcaagtcaga tttatgcagg gattaaagta aggcaattat     3720

gtaaacttct taggggaacc aaagcactaa cagaagtagt accactaaca gaagaagcag     3780

agctagaact ggcagaaaac agggagattc taaaagaacc ggtacatgga gtgtattatg     3840

acccatcaaa agacttaata gcagaaatac agaagcaggg gcaaggccaa tggacatatc     3900

aaatttatca agagccattt aaaaatctga aaacaggaaa gtatgcaaga atgaagggtg     3960

cccacactaa tgatgtgaaa caattaacag aggcagtaca aaaaatagcc acagaaagca     4020

tagtaatatg gggaaagact cctaaattta aattacccat acaaaaggaa acatgggaag     4080

catggtggac agagtattgg caagccacct ggattcctga gtgggagttt gtcaataccc     4140

ctcccttagt gaagttatgg taccagttag agaaagaacc cataatagga gcagaaactt     4200

tctatgtaga tggggcagcc aatagggaaa ctaaattagg aaaagcagga tatgtaactg     4260

acagaggaag acaaaaagtt gtccccctaa cggacacaac aaatcagaag actgagttac     4320

aagcaattca tctagctttg caggattcgg gattagaagt aaacatagtg acagactcac     4380

aatatgcatt gggaatcatt caagcacaac cagataagag tgaatcagag ttagtcagtc     4440

aaataataga gcagttaata aaaaaggaaa aagtctacct ggcatgggta ccagcacaca     4500

aaggaattgg aggaaatgaa caagtagata aattggtcag tgctggaatc aggaaagtac     4560

tatttttaga tggaatagat aaggcccaag aagaacatga gaaatatcac agtaattgga     4620

gagcaatggc tagtgatttt aacctaccac ctgtagtagc aaaagaaata gtagccagct     4680

gtgataaatg tcagctaaaa ggggaagcca tgcatggaca agtagactgt agcccaggaa     4740

tatggcagct agattgtaca catttagaag gaaaagttat cttggtagca gttcatgtag     4800

ccagtggata tatagaagca gaagtaattc cagcagagac agggcaagaa acagcatact     4860

tcctcttaaa attagcagga agatggccag taaaaacagt acatacagac aatggcagca     4920

atttcaccag tactacagtt aaggccgcct gttggtgggc ggggatcaag caggaatttg     4980

gcattcccta caatccccaa agtcaaggag taatagaatc tatgaataaa gaattaaaga     5040

aaattatagg acaggtaaga gatcaggctg aacatcttaa gacagcagta caaatggcag     5100

tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa     5160

tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa     5220

ttcaaaattt tcgggtttat tacagggaca gcagagatcc agtttggaaa ggaccagcaa     5280

agctcctctg gaaaggtgaa ggggcagtag taatacaaga taatagtgac ataaaagtag     5340

tgccaagaag aaaagcaaag atcatcaggg attatggaaa acagatggca ggtgatgatt     5400

gtgtggcaag tagacaggat gaggattaac acatggaatt ctgcaacaac tgctgtttat     5460

ccatttcaga attgggtgtc gacatagcag aataggcgtt actcgacaga ggagagcaag     5520

aaatggagcc agtagatcct agactagagc cctggaagca tccaggaagt cagcctaaaa     5580

ctgcttgtac caattgctat tgtaaaaagt gttgctttca ttgccaagtt tgtttcatga     5640

caaaagcctt aggcatctcc tatggcagga agaagcggag acagcgacga agagctcatc     5700

agaacagtca gactcatcaa gcttctctat caaagcagta agtagtacat gtaatgcaac     5760

ctataatagt agcaatagta gcattagtag tagcaataat aatagcaata gttgtgtggt     5820

ccatagtaat catagaatat aggaaaatgg ccgctgatct tcagacctgg aggaggagat     5880

atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat tgaaccatta     5940

ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag agcagtggga     6000

ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg cgcagcgtca     6060

atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca gcagaacaat     6120

ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg gggcatcaag     6180

cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca gctcctgggg     6240

atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa tgctagttgg     6300

agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg ggacagagaa     6360

attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa     6420

aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa ttggtttaac     6480

ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg cttggtaggt     6540

ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg atattcacca     6600

ttatcgtttc agacccacct cccaaccccg aggggacccg acaggcccga aggaatagaa     6660

gaagaaggtg gagagagaga cagagacaga tccattcgat tagtgaacgg atccttggca     6720

cttatctggg acgatctgcg gagcctgtgc ctcttcagct accaccgctt gagagactta     6780

ctcttgattg taacgaggat tgtggaactt ctgggacgca gggggtggga agccctcaaa     6840

tattggtgga atctcctaca atattggagt caggagctaa agaatagtgc tgttagcttg     6900

ctcaatgcca cagccatagc agtagctgag gggacagata gggttataga agtagtacaa     6960

ggagcttgta gagctattcg ccacatacct agaagaataa gacagggctt ggaaaggatt     7020

ttgctataag ctcgaaacaa ccggtacctc tagaactata gctagcagat ctttttccct     7080

ctgccaaaaa ttatggggac atcatgaagc cccttgagca tctgacttct ggctaataaa     7140

ggaaatttat tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagga     7200

catatgggag ggcaaatcat ttaaaacatc agaatgagta tttggtttag agtttggcaa     7260

catatgccca tatgctggct gccatgaaca aaggttggct ataaagaggt catcagtata     7320

tgaaacagcc ccctgctgtc cattccttat tccatagaaa agccttgact tgaggttaga     7380

ttttttttat attttgtttt gtgttatttt tttctttaac atccctaaaa ttttccttac     7440

atgttttact agccagattt ttcctcctct cctgactact cccagtcata gctgtccctc     7500

ttctcttatg gagatccctc gacctgcagc ccaagcttgg cgtaatcatg gtcatagctg     7560

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata     7620

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca     7680

ctgcccgctt tccagtcggg aaacctgtcg tgccagcgga tccgcatctc aattagtcag     7740

caaccatagt cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc     7800

attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctcgg     7860

cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa     7920

agctaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt     7980

cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt     8040

atcttatcat gtctggatcc gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     8100

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg     8160

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg     8220

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     8280

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     8340

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     8400

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     8460

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg     8520

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     8580

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     8640

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     8700

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct     8760

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     8820

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     8880

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     8940

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     9000

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     9060

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     9120

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     9180

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     9240

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     9300

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     9360

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     9420

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     9480

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     9540

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     9600

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     9660

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     9720

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     9780

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     9840

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     9900

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     9960

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg    10020

cgcacatttc cccgaaaagt gccacctggg tcgacattga ttattgacta gttattaata    10080

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact    10140

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat    10200

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta    10260

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc    10320

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg    10380

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtcgaggt    10440

gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc caattttgta    10500

tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg gggggcgggg    10560

cgaggggcgg ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct    10620

ccgaaagttt ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc    10680

gcggcgggcg                                                           10690


<210>  31
<211>  84
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptides

<400>  31

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Cys Met Gln Val Trp Pro Pro Ile 
    50                  55                  60                  


Gly Lys Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Pro Leu Thr Arg 
65                  70                  75                  80  


Asp Ser Arg Ala 
                


<210>  32
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  scaffold stem loop

<400>  32
ccagcgacua ugucguagug g                                                 21


<210>  33
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  34
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(28)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(28)
<223>  These individual nucleotides may be absent

<400>  34
uuunnnnnnn nnnnnnnnnn nnnnnnnnuu u                                      31


<210>  35
<211>  19
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  35
acaugaggau uacccaugu                                                    19


<210>  36
<211>  18
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  36
ugcaugucua agacagca                                                     18


<210>  37
<211>  20
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  37
aauccauugc acuccggauu                                                   20


<210>  38
<211>  12
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  38
ccucuucgga gg                                                           12


<210>  39
<211>  21
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  39
aggaguuucu auggaaaccc u                                                 21


<210>  40
<211>  30
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  40
aggugggacg accucucggu cguccuaucu                                        30


<210>  41
<211>  19
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  41
ugcucgcucc guucgagca                                                    19


<210>  42
<211>  21
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  42
ugcucgacgc guccucgagc a                                                 21


<210>  43
<211>  22
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  43
ugcucguuug cggcuacgag ca                                                22


<210>  44
<211>  17
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  44
agggagggag ggagagg                                                      17


<210>  45
<211>  19
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  45
gguuaggguu aggguuagg                                                    19


<210>  46
<211>  25
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  46
cugcucagua cgagaggaac cgcag                                             25


<210>  47
<211>  78
<212>  RNA
<213>  Unknown

<220>  
<223>  extended stem loop region

<400>  47
uacacuggga ucgcugaauu agagaucggc guccuuucau ucuauauacu uuggaguuuu       60

aaaaugucuc uaaguaca                                                     78


<210>  48
<211>  4
<212>  PRT
<213>  Unknown

<220>  
<223>  zinc finger/ribbon domain


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<400>  48

Cys Xaa Xaa Cys 
1               


<210>  49
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  49

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  50
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  50

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Thr Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser 
            820                 825                 830         


Asp Gly Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu 
    850                 855                 860                 


Leu Ser Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu 
            900                 905                 910         


Asp Cys Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  51
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  51

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys 
        195                 200                 205             


Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn 
                245                 250                 255     


Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu 
            260                 265                 270         


Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro 
305                 310                 315                 320 


Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg Arg 
                325                 330                 335     


Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys Leu 
            340                 345                 350         


Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val Thr 
        355                 360                 365             


Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro Asn 
    370                 375                 380                 


Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys Lys 
385                 390                 395                 400 


Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys Lys 
                405                 410                 415     


Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg Ile 
            420                 425                 430         


Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu Ala 
        435                 440                 445             


Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp Leu 
    450                 455                 460                 


Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp Glu 
465                 470                 475                 480 


Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly Asp 
                485                 490                 495     


Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val Asp 
            500                 505                 510         


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
        515                 520                 525             


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
    530                 535                 540                 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
545                 550                 555                 560 


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
                565                 570                 575     


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
            580                 585                 590         


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
        595                 600                 605             


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
    610                 615                 620                 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
625                 630                 635                 640 


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
                645                 650                 655     


Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp Arg 
            660                 665                 670         


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
        675                 680                 685             


Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile Leu 
    690                 695                 700                 


Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala Ala 
705                 710                 715                 720 


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe Ala 
                725                 730                 735     


Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala Arg 
            740                 745                 750         


Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe Glu 
        755                 760                 765             


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Thr 
    770                 775                 780                 


Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
785                 790                 795                 800 


Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln 
                805                 810                 815     


Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr Ala 
            820                 825                 830         


Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly Trp 
        835                 840                 845             


Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile Thr 
    850                 855                 860                 


Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser Ala 
865                 870                 875                 880 


Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser Lys 
                885                 890                 895     


Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys Arg 
            900                 905                 910         


Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys Gly 
        915                 920                 925             


His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser 
    930                 935                 940                 


Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys Ser 
945                 950                 955                 960 


Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg Arg 
                965                 970                 975     


Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985 


<210>  52
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  52

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
            820                 825                 830         


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
        835                 840                 845             


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
865                 870                 875                 880 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
                885                 890                 895     


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
        915                 920                 925             


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  53
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  53

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala 
        915                 920     


<210>  54
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  54

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala 
        915                 920 


<210>  55
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  55

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Asn Ala Ala 
    50                  55                  60                  


Asn Asn Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala 
65                  70                  75                  80  


Ile Leu Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu 
                85                  90                  95      


Met Cys Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  56
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  56

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  57
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  57

Met Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp 
1               5                   10                  15      


Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe 
            20                  25                  30          


Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro Ala Pro 
        35                  40                  45              


Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly Asn Glu 
    50                  55                  60                  


Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu 
65                  70                  75                  80  


Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro His Thr 
                85                  90                  95      


Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu Ile Leu 
            100                 105                 110         


Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser 
        115                 120                 125             


Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile His Val 
    130                 135                 140                 


Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile Gly Gly 
145                 150                 155                 160 


Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp Ala Cys 
                165                 170                 175     


Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu 
            180                 185                 190         


Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu 
        195                 200                 205             


Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu 
    210                 215                 220                 


Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val 
225                 230                 235                 240 


Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln Lys Leu 
                245                 250                 255     


Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe 
            260                 265                 270         


Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp 
        275                 280                 285             


Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp 
    290                 295                 300                 


Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala 
305                 310                 315                 320 


Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys 
                325                 330                 335     


Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu Lys Lys 
            340                 345                 350         


His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile 
        355                 360                 365             


Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu 
    370                 375                 380                 


Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu 
385                 390                 395                 400 


Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys 
                405                 410                 415     


Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp 
            420                 425                 430         


Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Arg Val Val Asp 
        435                 440                 445             


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
    450                 455                 460                 


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
465                 470                 475                 480 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
                485                 490                 495     


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
            500                 505                 510         


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
        515                 520                 525             


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
    530                 535                 540                 


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
545                 550                 555                 560 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
                565                 570                 575     


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
            580                 585                 590         


Val Asp Pro Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg 
        595                 600                 605             


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
    610                 615                 620                 


Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu 
625                 630                 635                 640 


Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys 
                645                 650                 655     


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala 
            660                 665                 670         


Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg 
        675                 680                 685             


Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu 
    690                 695                 700                 


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala 
705                 710                 715                 720 


Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
                725                 730                 735     


Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr 
            740                 745                 750         


Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp 
        755                 760                 765             


Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met 
    770                 775                 780                 


Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr 
785                 790                 795                 800 


Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu 
                805                 810                 815     


Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp 
            820                 825                 830         


Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe 
        835                 840                 845             


Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe 
    850                 855                 860                 


Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp 
865                 870                 875                 880 


Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr 
                885                 890                 895     


Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe 
            900                 905                 910         


Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
        915                 920                 925 


<210>  58
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  58

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Thr Ser Arg Ala Asn 
    50                  55                  60                  


Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu 
65                  70                  75                  80  


His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser 
                85                  90                  95      


Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys 
        195                 200                 205             


Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn 
                245                 250                 255     


Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu 
            260                 265                 270         


Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln 
                325                 330                 335     


Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
785                 790                 795                 800 


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
                805                 810                 815     


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
            820                 825                 830         


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
        835                 840                 845             


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
    850                 855                 860                 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
865                 870                 875                 880 


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
                885                 890                 895     


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
            900                 905                 910         


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
        915                 920                 925             


Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn 
    930                 935                 940                 


Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln 
945                 950                 955                 960 


Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975 


<210>  59
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  59

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Arg Val Val Asp Ile Ser Gly Phe Ser Ile Gly 
            500                 505                 510         


Ser Asp Gly His Ser Ile Gln Tyr Arg Asn Leu Leu Ala Trp Lys Tyr 
        515                 520                 525             


Leu Glu Asn Gly Lys Arg Glu Phe Tyr Leu Leu Met Asn Tyr Gly Lys 
    530                 535                 540                 


Lys Gly Arg Ile Arg Phe Thr Asp Gly Thr Asp Ile Lys Lys Ser Gly 
545                 550                 555                 560 


Lys Trp Gln Gly Leu Leu Tyr Gly Gly Gly Lys Ala Lys Val Ile Asp 
                565                 570                 575     


Leu Thr Phe Asp Pro Asp Asp Glu Gln Leu Ile Ile Leu Pro Leu Ala 
            580                 585                 590         


Phe Gly Thr Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Gly Leu Ile Lys Leu Ala Asn Gly Arg Val Ile Glu Lys 
    610                 615                 620                 


Thr Ile Tyr Asn Lys Lys Ile Gly Arg Asp Glu Pro Ala Leu Phe Val 
625                 630                 635                 640 


Ala Leu Thr Phe Glu Arg Arg Glu Val Val Asp Pro Ser Asn Ile Lys 
                645                 650                 655     


Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val 
            660                 665                 670         


Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp 
        675                 680                 685             


Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys 
    690                 695                 700                 


Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg 
705                 710                 715                 720 


Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala 
                725                 730                 735     


Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val 
            740                 745                 750         


Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly 
        755                 760                 765             


Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met 
    770                 775                 780                 


Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr 
785                 790                 795                 800 


Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn 
                805                 810                 815     


Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys 
            820                 825                 830         


Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu 
        835                 840                 845             


Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln 
    850                 855                 860                 


Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu 
865                 870                 875                 880 


Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu 
                885                 890                 895     


Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu 
            900                 905                 910         


Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln 
        915                 920                 925             


Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu 
    930                 935                 940                 


Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg 
945                 950                 955                 960 


Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu 
                965                 970                 975     


Val Trp Lys Pro Ala Val 
            980         


<210>  60
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  60

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  61
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  61

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala 
    


<210>  62
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  62

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  63
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  63

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Gln Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  64
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  64

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Gln Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  65
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  65

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Ile Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  66
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  66

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  67
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  67

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  68
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  68

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  69
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  69

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  70
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  70

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Lys Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  71
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  71

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  72
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  72

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  73
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  73

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  74
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  74

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  75
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  75

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  76
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  76

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Asp Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  77
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  77

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Phe Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  78
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  78

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  79
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  79

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  80
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  80

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  81
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  81

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  82
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  82

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Lys Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  83
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  83

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  84
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  84

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Met Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  85
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  85

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  86
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  86

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  87
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  87

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  88
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  88

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  89
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  89

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Val 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  90
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  90

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  91
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  91

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  92
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  92

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  93
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  93

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  94
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  94

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  95
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  95

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  96
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  96

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  97
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  97

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  98
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  98

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  99
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  99

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  100
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  100

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  101
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  101

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  102
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  102

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  103
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  103

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  104
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  104

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  105
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  105

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  106
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  106

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  107
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  107

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  108
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  108

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  109
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  109

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  110
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  110

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  111
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  111

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  112
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  112

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  113
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  113

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  114
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  114

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  115
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  115

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  116
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  116

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  117
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  117

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  118
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  118

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  119
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  119

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  120
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  120

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  121
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  121

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  122
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  122

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  123
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  123

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  124
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  124

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  125
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  125

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  126
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  126

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  127
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  127

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  128
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  128

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  129
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  129

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  130
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  130

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  131
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  131

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  132
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  132

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  133
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  133

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  134
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  134

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  135
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  135

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  136
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  136

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  137
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  137

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  138
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  138

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  139
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  139

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  140
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  140

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Gly Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  141
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  141

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  142
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  142

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  143
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  143

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         


<210>  144
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  144

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  145
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  145

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  146
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  146

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn His Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  147
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  147

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Ala 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  148
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  148

Arg Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Ala Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala 
225                 230                 235                 240 


Ser Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val 
                245                 250                 255     


Val Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly 
            260                 265                 270         


Lys Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His 
        275                 280                 285             


Thr Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg 
    290                 295                 300                 


Met Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp 
305                 310                 315                 320 


Asp Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu 
                325                 330                 335     


Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn 
            340                 345                 350         


Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp 
        355                 360                 365             


Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu 
    370                 375                 380                 


Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln 
385                 390                 395                 400 


Leu Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp 
                405                 410                 415     


Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu 
            420                 425                 430         


Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp 
        435                 440                 445             


Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser 
    450                 455                 460                 


Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg 
465                 470                 475                 480 


Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro 
                485                 490                 495     


Phe Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser 
            500                 505                 510         


Lys Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys 
        515                 520                 525             


Leu Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg 
    530                 535                 540                 


Phe Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr 
545                 550                 555                 560 


Val Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe 
                565                 570                 575     


Asn Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys 
            580                 585                 590         


Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr 
        595                 600                 605             


Gly Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr 
    610                 615                 620                 


Asn Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr 
625                 630                 635                 640 


Phe Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn 
                645                 650                 655     


Leu Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu 
            660                 665                 670         


Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly 
        675                 680                 685             


Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln 
    690                 695                 700                 


Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly 
705                 710                 715                 720 


Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met 
                725                 730                 735     


Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp 
            740                 745                 750         


Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly 
        755                 760                 765             


Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp 
    770                 775                 780                 


Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  149
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  149

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Gln Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  150
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  150

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Thr Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  151
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  151

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Arg Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  152
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  152

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Tyr Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  153
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  153

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


His Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  154
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  154

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Ala Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  155
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  155

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  156
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  156

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Arg Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His 
        195                 200                 205             


Pro Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser 
225                 230                 235                 240 


Phe Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val 
                245                 250                 255     


Lys Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys 
            260                 265                 270         


Glu Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp 
305                 310                 315                 320 


Ala Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  157
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  157

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Tyr Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  158
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  158

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Asn Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  159
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  159

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Trp Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  160
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  160

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Tyr Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  161
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  161

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  162
<211>  38
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  162

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  163
<211>  42
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  163

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  164
<211>  8
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  164

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  165
<211>  8
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  165

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  166
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  166

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  167
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  167

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  168
<211>  5
<212>  PRT
<213>  Alphainfluenzavirus influenza A virus

<400>  168

Asp Arg Leu Arg Arg 
1               5   


<210>  169
<211>  7
<212>  PRT
<213>  Alphainfluenzavirus influenza A virus

<400>  169

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  170
<211>  10
<212>  PRT
<213>  Deltavirus hepatitis delta virus

<400>  170

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  171
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  171

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  172
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  172

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  173
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  173

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  174
<211>  8
<212>  PRT
<213>  Orthobornavirus mammalian 1 orthobornavirus

<400>  174

Pro Arg Pro Arg Lys Ile Pro Arg 
1               5               


<210>  175
<211>  9
<212>  PRT
<213>  Hepacivirus hepacivirus C

<400>  175

Pro Pro Arg Lys Lys Arg Thr Val Val 
1               5                   


<210>  176
<211>  12
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  176

Asn Leu Ser Lys Lys Lys Lys Arg Lys Arg Glu Lys 
1               5                   10          


<210>  177
<211>  10
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  177

Arg Arg Pro Ser Arg Pro Phe Arg Lys Pro 
1               5                   10  


<210>  178
<211>  8
<212>  PRT
<213>  Lymphocryptovirus human gammaherpesvirus 4

<400>  178

Lys Arg Pro Arg Ser Pro Ser Ser 
1               5               


<210>  179
<211>  19
<212>  PRT
<213>  Alphainfluenzavirus influenza A virus

<400>  179

Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly Glu Asn Glu Arg 
1               5                   10                  15      


Lys Thr Arg 
            


<210>  180
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  180

Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn 
1               5                   10      


<210>  181
<211>  8
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  181

Lys Arg Ser Phe Ser Lys Ala Phe 
1               5               


<210>  182
<211>  9
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  182

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  183
<211>  19
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  183

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys Arg Val 
1               5                   10                  15      


Lys Leu Asp 
            


<210>  184
<211>  17
<212>  PRT
<213>  Deltaretrovirus human T-lymphotropic virus 1

<400>  184

Pro Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro 
1               5                   10                  15      


Thr 
    


<210>  185
<211>  25
<212>  PRT
<213>  Caenorhabditis elegans

<400>  185

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  186
<211>  16
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  186

Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro Thr 
1               5                   10                  15      


<210>  187
<211>  13
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  187

Arg Arg Lys Lys Arg Arg Pro Arg Arg Lys Lys Arg Arg 
1               5                   10              


<210>  188
<211>  14
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  188

Pro Lys Lys Lys Ser Arg Lys Pro Lys Lys Lys Ser Arg Lys 
1               5                   10                  


<210>  189
<211>  17
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  189

His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210>  190
<211>  18
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  190

Gln Arg Pro Gly Pro Tyr Asp Arg Pro Gln Arg Pro Gly Pro Tyr Asp 
1               5                   10                  15      


Arg Pro 
        


<210>  191
<211>  16
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  191

Leu Ser Pro Ser Leu Ser Pro Leu Leu Ser Pro Ser Leu Ser Pro Leu 
1               5                   10                  15      


<210>  192
<211>  18
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  192

Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210>  193
<211>  14
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  193

Pro Lys Arg Gly Arg Gly Arg Pro Lys Arg Gly Arg Gly Arg 
1               5                   10                  


<210>  194
<211>  17
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  194

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val 
    


<210>  195
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus 1

<400>  195

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  196
<211>  8
<212>  PRT
<213>  Human immunodeficiency virus 1

<400>  196

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  197
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus 1

<400>  197

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  198
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus 1

<400>  198

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  199
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus 1

<400>  199

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  200
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain


<220>
<221>  MISC_FEATURE
<222>  (4)..(50)
<223>  These individual amino acid residues may be present or absent

<400>  200

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40                  45              


Arg Arg 
    50  


<210>  201
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain

<400>  201

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  202
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain

<400>  202

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  203
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain

<400>  203

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  204
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  peptide transduction domain

<400>  204

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  205

Gly Ser Gly Gly Ser 
1               5   


<210>  206
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  206

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  207
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  207

Gly Gly Gly Ser 
1               


<210>  208
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  208

Gly Gly Ser Gly 
1               


<210>  209
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  209

Gly Gly Ser Gly Gly 
1               5   


<210>  210
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  210

Gly Ser Gly Ser Gly 
1               5   


<210>  211
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  211

Gly Ser Gly Gly Gly 
1               5   


<210>  212
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  212

Gly Gly Gly Ser Gly 
1               5   


<210>  213
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  213

Gly Ser Ser Ser Gly 
1               5   


<210>  214
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  214

Gly Pro Gly Pro 
1               


<210>  215
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  215

Pro Pro Ala Pro Pro Ala 
1               5       


<210>  216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  linker polypeptide

<400>  216

Pro Pro Pro Gly Pro Pro Pro 
1               5           


<210>  217
<211>  7
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  217

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  218
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  TTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is a, c, g, or t

<400>  218
nnttcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  219
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is a, c, g, or t

<400>  219
nnctcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  220
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  GTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is a, c, g, or t

<400>  220
nngtcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  221
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  ATC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is a, c, g, or t

<400>  221
nnatcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  222
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  TC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is a, c, g, or t

<400>  222
nnntcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  223
<211>  16
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  223

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  224
<211>  9
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  224

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  225
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mouse PCSK9 targeting sequence

<400>  225
gaggctagag gactgagcca                                                   20


<210>  226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  mouse PCSK9 targeting sequence

<400>  226
gaggcuagag gacugagcca                                                   20


<210>  227
<211>  4550
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AAV construct

<400>  227
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgaggc gttgacattg attattgact agttattaat      180

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac      240

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa      300

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt      360

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc      420

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat      480

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc      540

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc      600

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa      660

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg      720

tctatataag cagagctctc tggctaacta ccggtgccac catggcccca aagaagaagc      780

ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg      840

acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga      900

tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc      960

agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga     1020

tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga     1080

tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga     1140

tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc     1200

tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg     1260

gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga     1320

aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact     1380

tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg     1440

ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa     1500

caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca     1560

agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat     1620

accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg     1680

aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt     1740

ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg     1800

aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca     1860

acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag     1920

aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca     1980

gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca     2040

aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca     2100

ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt     2160

ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt     2220

tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg     2280

ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg     2340

ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact     2400

tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat     2460

tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact     2520

tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt     2580

tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag     2640

tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg     2700

ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga     2760

tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat     2820

gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg     2880

agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa cagcgcagag     2940

ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc     3000

gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg     3060

agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt     3120

acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct     3180

acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca     3240

tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga     3300

tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt     3360

acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga     3420

gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc     3480

tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct     3540

tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga     3600

gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg     3660

cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg     3720

ccgtgggatc cccaaaaaag aagagaaagg tatacccata tgatgtccct gactacgctg     3780

gatcctaaga attcctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc     3840

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     3900

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     3960

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagagaata gcaggcatgc     4020

tggggaggta ccgtgagggc ctatttccca tgattccttc atatttgcat atacgataca     4080

aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata ttagtacaaa     4140

atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa ttatgtttta     4200

aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg gctttatata     4260

tcttgtggaa aggacgaaac accactggcg cttttatctg attactttga gagccatcac     4320

cagcgactat gtcgtagtgg gtaaagctcc ctcttcggag ggagcatcaa aggaggctag     4380

aggactgagc catttttttt ggcggccgca ggaaccccta gtgatggagt tggccactcc     4440

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4500

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc tgcctgcagg                4550


<210>  228
<211>  4965
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AAV construct

<400>  228
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgaggg cctccgcgcc gggttttggc gcctcccgcg      180

ggcgcccccc tcctcacggc gagcgctgcc acgtcagacg aagggcgcag cgagcgtcct      240

gatccttccg cccggacgct caggacagcg gcccgctgct cataagactc ggccttagaa      300

ccccagtatc agcagaagga cattttagga cgggacttgg gtgactctag ggcactggtt      360

ttctttccag agagcggaac aggcgaggaa aagtagtccc ttctcggcga ttctgcggag      420

ggatctccgt ggggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      480

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgtggatcg ctgtgatcgt      540

cacttggtac cggtgccacc atggccccaa agaagaagcg gaaggtctct agacaagaga      600

tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca aagaaggccg      660

gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac ctgagagagc      720

ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc aacaccagca      780

gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc atcctgcacg      840

tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt gctcagcctg      900

ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag ggcaatctga      960

ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac aagctggaac     1020

aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac gtggccgagc     1080

acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat gaggccgtga     1140

cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc cacgtgacca     1200

aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga tacgcctctg     1260

gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc ttcctgagca     1320

agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag aagagactgg     1380

aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg accctgcctc     1440

ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc agagtgagaa     1500

tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac gccaagcctc     1560

tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg     1620

attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca     1680

aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga     1740

gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg ggcgacctgc     1800

tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg     1860

agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa     1920

ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct     1980

ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc     2040

tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca     2100

tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg     2160

gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt     2220

tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa     2280

agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta     2340

tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga     2400

gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca     2460

acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag     2520

aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac cggggcgaga     2580

atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg     2640

actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga     2700

ggacaatcca ggccaagaaa gaggtggaac agcgcagagc cggcggatac tctaggaagt     2760

acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc     2820

tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg     2880

gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc     2940

tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc     3000

agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca     3060

gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag     3120

agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga     3180

aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca     3240

gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca     3300

gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac     3360

aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt     3420

accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga     3480

gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgggatcc ccaaaaaaga     3540

agagaaaggt atacccatat gatgtccctg actacgctgg atcctaagaa ttccggggcg     3600

cgtctggaac atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat     3660

tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca     3720

tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc     3780

tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc     3840

tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt     3900

cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     3960

gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc     4020

ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta     4080

cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg     4140

gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc     4200

cccgaattcc tagagctcgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg     4260

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     4320

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     4380

gtggggtggg gcaggacagc aagggggagg attgggaaga gaatagcagg catgctgggg     4440

aggtaccgtg agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct     4500

gttagagaga taattggaat taatttgact gtaaacacaa agatattagt acaaaatacg     4560

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg     4620

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg     4680

tggaaaggac gaaacaccac tggcgctttt atctgattac tttgagagcc atcaccagcg     4740

actatgtcgt agtgggtaaa gctccctctt cggagggagc atcaaaggag gctagaggac     4800

tgagccattt tttttggcgg ccgcaggaac ccctagtgat ggagttggcc actccctctc     4860

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4920

cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct gcagg                     4965


<210>  229
<211>  4619
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AAV construct

<400>  229
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgaggg cctccgcgcc gggttttggc gcctcccgcg      180

ggcgcccccc tcctcacggc gagcgctgcc acgtcagacg aagggcgcag cgagcgtcct      240

gatccttccg cccggacgct caggacagcg gcccgctgct cataagactc ggccttagaa      300

ccccagtatc agcagaagga cattttagga cgggacttgg gtgactctag ggcactggtt      360

ttctttccag agagcggaac aggcgaggaa aagtagtccc ttctcggcga ttctgcggag      420

ggatctccgt ggggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      480

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgtggatcg ctgtgatcgt      540

cacttggtac cggtgccacc atggccccaa agaagaagcg gaaggtctct agacaagaga      600

tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca aagaaggccg      660

gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac ctgagagagc      720

ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc aacaccagca      780

gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc atcctgcacg      840

tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt gctcagcctg      900

ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag ggcaatctga      960

ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac aagctggaac     1020

aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac gtggccgagc     1080

acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat gaggccgtga     1140

cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc cacgtgacca     1200

aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga tacgcctctg     1260

gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc ttcctgagca     1320

agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag aagagactgg     1380

aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg accctgcctc     1440

ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc agagtgagaa     1500

tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac gccaagcctc     1560

tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg     1620

attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca     1680

aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga     1740

gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg ggcgacctgc     1800

tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg     1860

agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa     1920

ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct     1980

ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc     2040

tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca     2100

tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg     2160

gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt     2220

tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa     2280

agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta     2340

tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga     2400

gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca     2460

acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag     2520

aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac cggggcgaga     2580

atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg     2640

actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga     2700

ggacaatcca ggccaagaaa gaggtggaac agcgcagagc cggcggatac tctaggaagt     2760

acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc     2820

tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg     2880

gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc     2940

tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc     3000

agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca     3060

gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag     3120

agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga     3180

aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca     3240

gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca     3300

gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac     3360

aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt     3420

accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga     3480

gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgggatcc ccaaaaaaga     3540

agagaaaggt atacccatat gatgtccctg actacgctgg atcctaagaa ttccggggcg     3600

cgtctggaac gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct     3660

taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc     3720

tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt tagttcttgc     3780

cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg     3840

cactgacaat tccgtgggaa ttcctagagc tcgctgatca gcctcgactg tgccttctag     3900

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     3960

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     4020

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagagaatag     4080

caggcatgct ggggaggtac cgtgagggcc tatttcccat gattccttca tatttgcata     4140

tacgatacaa ggctgttaga gagataattg gaattaattt gactgtaaac acaaagatat     4200

tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg gtagtttgca gttttaaaat     4260

tatgttttaa aatggactat catatgctta ccgtaacttg aaagtatttc gatttcttgg     4320

ctttatatat cttgtggaaa ggacgaaaca ccactggcgc ttttatctga ttactttgag     4380

agccatcacc agcgactatg tcgtagtggg taaagctccc tcttcggagg gagcatcaaa     4440

ggaggctaga ggactgagcc attttttttg gcggccgcag gaacccctag tgatggagtt     4500

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     4560

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct gcctgcagg      4619


<210>  230
<211>  4550
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AAV construct

<400>  230
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgaggc gttgacattg attattgact agttattaat      180

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac      240

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa      300

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt      360

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc      420

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat      480

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc      540

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc      600

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa      660

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg      720

tctatataag cagagctctc tggctaacta ccggtgccac catggcccca aagaagaagc      780

ggaaggtctc tagacaagag atcaagagaa tcaacaagat cagaaggaga ctggtcaagg      840

acagcaacac aaagaaggcc ggcaagacag gccccatgaa aaccctgctc gtcagagtga      900

tgacccctga cctgagagag cggctggaaa acctgagaaa gaagcccgag aacatccctc      960

agcctatcag caacaccagc agggccaacc tgaacaagct gctgaccgac tacaccgaga     1020

tgaagaaagc catcctgcac gtgtactggg aagagttcca gaaagacccc gtgggcctga     1080

tgagcagagt tgctcagcct gccagcaaga agatcgacca gaacaagctg aagcccgaga     1140

tggacgagaa gggcaatctg accacagccg gctttgcctg ctctcagtgt ggccagcctc     1200

tgttcgtgta caagctggaa caggtgtccg agaaaggcaa ggcctacacc aactacttcg     1260

gcagatgtaa cgtggccgag cacgagaagc tgattctgct ggcccagctg aaacctgaga     1320

aggactctga tgaggccgtg acctacagcc tgggcaagtt tggacagaga gccctggact     1380

tctacagcat ccacgtgacc aaagaaagca cacaccccgt gaagcccctg gctcagatcg     1440

ccggcaatag atacgcctct ggacctgtgg gcaaagccct gtccgatgcc tgcatgggaa     1500

caatcgccag cttcctgagc aagtaccagg acatcatcat cgagcaccag aaggtggtca     1560

agggcaacca gaagagactg gaaagcctga gggagctggc cggcaaagag aacctggaat     1620

accccagcgt gaccctgcct cctcagcctc acacaaaaga aggcgtggac gcctacaacg     1680

aagtgatcgc cagagtgaga atgtgggtca acctgaacct gtggcagaag ctgaaactgt     1740

ccagggacga cgccaagcct ctgctgagac tgaagggctt ccctagcttc cctctggtgg     1800

aaagacaggc caatgaagtg gattggtggg acatggtctg caacgtgaag aagctgatca     1860

acgagaagaa agaggatggc aaggttttct ggcagaacct ggccggctac aagagacaag     1920

aagccctgag gccttacctg agcagcgaag aggaccggaa gaagggcaag aagttcgcca     1980

gataccagct gggcgacctg ctgctgcacc tggaaaagaa gcacggcgag gactggggca     2040

aagtgtacga tgaggcctgg gagagaatcg acaagaaggt ggaaggcctg agcaagcaca     2100

ttaagctgga agaggaaaga aggagcgagg acgcccaatc taaagccgct ctgaccgatt     2160

ggctgagagc caaggccagc tttgtgatcg agggcctgaa agaggccgac aaggacgagt     2220

tctgcagatg cgagctgaag ctgcagaagt ggtacggcga tctgagaggc aagcccttcg     2280

ccattgaggc cgagaacagc atcctggaca tcagcggctt cagcaagcag tacaactgcg     2340

ccttcatttg gcagaaagac ggcgtcaaga aactgaacct gtacctgatc atcaattact     2400

tcaaaggcgg caagctgcgg ttcaagaaga tcaaacccga ggccttcgag gctaacagat     2460

tctacaccgt gatcaacaaa aagtccggcg agatcgtgcc catggaagtg aacttcaact     2520

tcgacgaccc caacctgatt atcctgcctc tggccttcgg caagagacag ggcagagagt     2580

tcatctggaa cgatctgctg agcctggaaa ccggctctct gaagctggcc aatggcagag     2640

tgatcgagaa aaccctgtac aacaggagaa ccagacagga cgagcctgct ctgtttgtgg     2700

ccctgacctt cgagagaaga gaggtgctgg acagcagcaa catcaagccc atgaacctga     2760

tcggcgtgga ccggggcgag aatatccctg ctgtgatcgc cctgacagac cctgaaggat     2820

gcccactgag cagattcaag gactccctgg gcaaccctac acacatcctg agaatcggcg     2880

agagctacaa agagaagcag aggacaatcc aggccaagaa agaggtggaa cagcgcagag     2940

ccggcggata ctctaggaag tacgccagca aggccaagaa tctggccgac gacatggtcc     3000

gaaacaccgc cagagatctg ctgtactacg ccgtgacaca ggacgccatg ctgatcttcg     3060

agaatctgag cagaggcttc ggccggcagg gcaagagaac ctttatggcc gagaggcagt     3120

acaccagaat ggaagattgg ctcacagcta aactggccta cgagggactg agcaagacct     3180

acctgtccaa aacactggcc cagtatacct ccaagacctg cagcaattgc ggcttcacca     3240

tcaccagcgc cgactacgac agagtgctgg aaaagctcaa gaaaaccgcc accggctgga     3300

tgaccaccat caacggcaaa gagctgaagg ttgagggcca gatcacctac tacaacaggt     3360

acaagaggca gaacgtcgtg aaggatctga gcgtggaact ggacagactg agcgaagaga     3420

gcgtgaacaa cgacatcagc agctggacaa agggcagatc aggcgaggct ctgagcctgc     3480

tgaagaagag gtttagccac agacctgtgc aagagaagtt cgtgtgcctg aactgcggct     3540

tcgagacaca cgccgatgaa caggctgccc tgaacattgc cagaagctgg ctgttcctga     3600

gaagccaaga gtacaagaag taccagacca acaagaccac cggcaacacc gacaagaggg     3660

cctttgtgga aacctggcag agcttctaca gaaaaaagct gaaagaagtc tggaagcccg     3720

ccgtgggatc cccaaaaaag aagagaaagg tatacccata tgatgtccct gactacgctg     3780

gatcctaaga attcctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc     3840

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     3900

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     3960

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagagaata gcaggcatgc     4020

tggggaggta ccgtgagggc ctatttccca tgattccttc atatttgcat atacgataca     4080

aggctgttag agagataatt ggaattaatt tgactgtaaa cacaaagata ttagtacaaa     4140

atacgtgacg tagaaagtaa taatttcttg ggtagtttgc agttttaaaa ttatgtttta     4200

aaatggacta tcatatgctt accgtaactt gaaagtattt cgatttcttg gctttatata     4260

tcttgtggaa aggacgaaac accactggcg cttttatctg attactttga gagccatcac     4320

cagcgactat gtcgtagtgg gtaaagctcc ctcttcggag ggagcatcaa agtggcttcc     4380

tggtgaagat gatttttttt ggcggccgca ggaaccccta gtgatggagt tggccactcc     4440

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4500

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc tgcctgcagg                4550


<210>  231
<211>  4965
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AAV construct

<400>  231
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgaggg cctccgcgcc gggttttggc gcctcccgcg      180

ggcgcccccc tcctcacggc gagcgctgcc acgtcagacg aagggcgcag cgagcgtcct      240

gatccttccg cccggacgct caggacagcg gcccgctgct cataagactc ggccttagaa      300

ccccagtatc agcagaagga cattttagga cgggacttgg gtgactctag ggcactggtt      360

ttctttccag agagcggaac aggcgaggaa aagtagtccc ttctcggcga ttctgcggag      420

ggatctccgt ggggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      480

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgtggatcg ctgtgatcgt      540

cacttggtac cggtgccacc atggccccaa agaagaagcg gaaggtctct agacaagaga      600

tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca aagaaggccg      660

gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac ctgagagagc      720

ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc aacaccagca      780

gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc atcctgcacg      840

tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt gctcagcctg      900

ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag ggcaatctga      960

ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac aagctggaac     1020

aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac gtggccgagc     1080

acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat gaggccgtga     1140

cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc cacgtgacca     1200

aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga tacgcctctg     1260

gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc ttcctgagca     1320

agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag aagagactgg     1380

aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg accctgcctc     1440

ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc agagtgagaa     1500

tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac gccaagcctc     1560

tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg     1620

attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca     1680

aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga     1740

gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg ggcgacctgc     1800

tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg     1860

agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa     1920

ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct     1980

ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc     2040

tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca     2100

tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg     2160

gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt     2220

tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa     2280

agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta     2340

tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga     2400

gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca     2460

acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag     2520

aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac cggggcgaga     2580

atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg     2640

actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga     2700

ggacaatcca ggccaagaaa gaggtggaac agcgcagagc cggcggatac tctaggaagt     2760

acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc     2820

tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg     2880

gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc     2940

tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc     3000

agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca     3060

gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag     3120

agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga     3180

aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca     3240

gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca     3300

gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac     3360

aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt     3420

accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga     3480

gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgggatcc ccaaaaaaga     3540

agagaaaggt atacccatat gatgtccctg actacgctgg atcctaagaa ttccggggcg     3600

cgtctggaac atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat     3660

tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca     3720

tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc     3780

tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc     3840

tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt     3900

cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     3960

gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc     4020

ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta     4080

cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg     4140

gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc     4200

cccgaattcc tagagctcgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg     4260

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     4320

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     4380

gtggggtggg gcaggacagc aagggggagg attgggaaga gaatagcagg catgctgggg     4440

aggtaccgtg agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct     4500

gttagagaga taattggaat taatttgact gtaaacacaa agatattagt acaaaatacg     4560

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg     4620

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg     4680

tggaaaggac gaaacaccac tggcgctttt atctgattac tttgagagcc atcaccagcg     4740

actatgtcgt agtgggtaaa gctccctctt cggagggagc atcaaagtgg cttcctggtg     4800

aagatgattt tttttggcgg ccgcaggaac ccctagtgat ggagttggcc actccctctc     4860

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4920

cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct gcagg                     4965


<210>  232
<211>  4619
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  AAV construct

<400>  232
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgaggg cctccgcgcc gggttttggc gcctcccgcg      180

ggcgcccccc tcctcacggc gagcgctgcc acgtcagacg aagggcgcag cgagcgtcct      240

gatccttccg cccggacgct caggacagcg gcccgctgct cataagactc ggccttagaa      300

ccccagtatc agcagaagga cattttagga cgggacttgg gtgactctag ggcactggtt      360

ttctttccag agagcggaac aggcgaggaa aagtagtccc ttctcggcga ttctgcggag      420

ggatctccgt ggggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      480

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgtggatcg ctgtgatcgt      540

cacttggtac cggtgccacc atggccccaa agaagaagcg gaaggtctct agacaagaga      600

tcaagagaat caacaagatc agaaggagac tggtcaagga cagcaacaca aagaaggccg      660

gcaagacagg ccccatgaaa accctgctcg tcagagtgat gacccctgac ctgagagagc      720

ggctggaaaa cctgagaaag aagcccgaga acatccctca gcctatcagc aacaccagca      780

gggccaacct gaacaagctg ctgaccgact acaccgagat gaagaaagcc atcctgcacg      840

tgtactggga agagttccag aaagaccccg tgggcctgat gagcagagtt gctcagcctg      900

ccagcaagaa gatcgaccag aacaagctga agcccgagat ggacgagaag ggcaatctga      960

ccacagccgg ctttgcctgc tctcagtgtg gccagcctct gttcgtgtac aagctggaac     1020

aggtgtccga gaaaggcaag gcctacacca actacttcgg cagatgtaac gtggccgagc     1080

acgagaagct gattctgctg gcccagctga aacctgagaa ggactctgat gaggccgtga     1140

cctacagcct gggcaagttt ggacagagag ccctggactt ctacagcatc cacgtgacca     1200

aagaaagcac acaccccgtg aagcccctgg ctcagatcgc cggcaataga tacgcctctg     1260

gacctgtggg caaagccctg tccgatgcct gcatgggaac aatcgccagc ttcctgagca     1320

agtaccagga catcatcatc gagcaccaga aggtggtcaa gggcaaccag aagagactgg     1380

aaagcctgag ggagctggcc ggcaaagaga acctggaata ccccagcgtg accctgcctc     1440

ctcagcctca cacaaaagaa ggcgtggacg cctacaacga agtgatcgcc agagtgagaa     1500

tgtgggtcaa cctgaacctg tggcagaagc tgaaactgtc cagggacgac gccaagcctc     1560

tgctgagact gaagggcttc cctagcttcc ctctggtgga aagacaggcc aatgaagtgg     1620

attggtggga catggtctgc aacgtgaaga agctgatcaa cgagaagaaa gaggatggca     1680

aggttttctg gcagaacctg gccggctaca agagacaaga agccctgagg ccttacctga     1740

gcagcgaaga ggaccggaag aagggcaaga agttcgccag ataccagctg ggcgacctgc     1800

tgctgcacct ggaaaagaag cacggcgagg actggggcaa agtgtacgat gaggcctggg     1860

agagaatcga caagaaggtg gaaggcctga gcaagcacat taagctggaa gaggaaagaa     1920

ggagcgagga cgcccaatct aaagccgctc tgaccgattg gctgagagcc aaggccagct     1980

ttgtgatcga gggcctgaaa gaggccgaca aggacgagtt ctgcagatgc gagctgaagc     2040

tgcagaagtg gtacggcgat ctgagaggca agcccttcgc cattgaggcc gagaacagca     2100

tcctggacat cagcggcttc agcaagcagt acaactgcgc cttcatttgg cagaaagacg     2160

gcgtcaagaa actgaacctg tacctgatca tcaattactt caaaggcggc aagctgcggt     2220

tcaagaagat caaacccgag gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa     2280

agtccggcga gatcgtgccc atggaagtga acttcaactt cgacgacccc aacctgatta     2340

tcctgcctct ggccttcggc aagagacagg gcagagagtt catctggaac gatctgctga     2400

gcctggaaac cggctctctg aagctggcca atggcagagt gatcgagaaa accctgtaca     2460

acaggagaac cagacaggac gagcctgctc tgtttgtggc cctgaccttc gagagaagag     2520

aggtgctgga cagcagcaac atcaagccca tgaacctgat cggcgtggac cggggcgaga     2580

atatccctgc tgtgatcgcc ctgacagacc ctgaaggatg cccactgagc agattcaagg     2640

actccctggg caaccctaca cacatcctga gaatcggcga gagctacaaa gagaagcaga     2700

ggacaatcca ggccaagaaa gaggtggaac agcgcagagc cggcggatac tctaggaagt     2760

acgccagcaa ggccaagaat ctggccgacg acatggtccg aaacaccgcc agagatctgc     2820

tgtactacgc cgtgacacag gacgccatgc tgatcttcga gaatctgagc agaggcttcg     2880

gccggcaggg caagagaacc tttatggccg agaggcagta caccagaatg gaagattggc     2940

tcacagctaa actggcctac gagggactga gcaagaccta cctgtccaaa acactggccc     3000

agtatacctc caagacctgc agcaattgcg gcttcaccat caccagcgcc gactacgaca     3060

gagtgctgga aaagctcaag aaaaccgcca ccggctggat gaccaccatc aacggcaaag     3120

agctgaaggt tgagggccag atcacctact acaacaggta caagaggcag aacgtcgtga     3180

aggatctgag cgtggaactg gacagactga gcgaagagag cgtgaacaac gacatcagca     3240

gctggacaaa gggcagatca ggcgaggctc tgagcctgct gaagaagagg tttagccaca     3300

gacctgtgca agagaagttc gtgtgcctga actgcggctt cgagacacac gccgatgaac     3360

aggctgccct gaacattgcc agaagctggc tgttcctgag aagccaagag tacaagaagt     3420

accagaccaa caagaccacc ggcaacaccg acaagagggc ctttgtggaa acctggcaga     3480

gcttctacag aaaaaagctg aaagaagtct ggaagcccgc cgtgggatcc ccaaaaaaga     3540

agagaaaggt atacccatat gatgtccctg actacgctgg atcctaagaa ttccggggcg     3600

cgtctggaac gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct     3660

taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc     3720

tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt tagttcttgc     3780

cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg     3840

cactgacaat tccgtgggaa ttcctagagc tcgctgatca gcctcgactg tgccttctag     3900

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     3960

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     4020

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagagaatag     4080

caggcatgct ggggaggtac cgtgagggcc tatttcccat gattccttca tatttgcata     4140

tacgatacaa ggctgttaga gagataattg gaattaattt gactgtaaac acaaagatat     4200

tagtacaaaa tacgtgacgt agaaagtaat aatttcttgg gtagtttgca gttttaaaat     4260

tatgttttaa aatggactat catatgctta ccgtaacttg aaagtatttc gatttcttgg     4320

ctttatatat cttgtggaaa ggacgaaaca ccactggcgc ttttatctga ttactttgag     4380

agccatcacc agcgactatg tcgtagtggg taaagctccc tcttcggagg gagcatcaaa     4440

gtggcttcct ggtgaagatg attttttttg gcggccgcag gaacccctag tgatggagtt     4500

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     4560

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct gcctgcagg      4619


<210>  233
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  233
gcctcgccct ccccagacag                                                   20


<210>  234
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  234
gatggggctc ggggtggcgt                                                   20


<210>  235
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  235
ggggtgtggg tactggacgc                                                   20


<210>  236
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  236
cgtggacgcg caggctgccg                                                   20


<210>  237
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  237
gaggctagag gactgagcca                                                   20


<210>  238
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  238
cgaggccgcg cgcacctctc                                                   20


<210>  239
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  239
taatctccat cctcgtcctg                                                   20


<210>  240
<211>  20
<212>  RNA
<213>  Mus musculus

<400>  240
gccucgcccu ccccagacag                                                   20


<210>  241
<211>  20
<212>  RNA
<213>  Mus musculus

<400>  241
gauggggcuc gggguggcgu                                                   20


<210>  242
<211>  20
<212>  RNA
<213>  Mus musculus

<400>  242
gggguguggg uacuggacgc                                                   20


<210>  243
<211>  20
<212>  RNA
<213>  Mus musculus

<400>  243
cguggacgcg caggcugccg                                                   20


<210>  244
<211>  20
<212>  RNA
<213>  Mus musculus

<400>  244
gaggcuagag gacugagcca                                                   20


<210>  245
<211>  20
<212>  RNA
<213>  Mus musculus

<400>  245
cgaggccgcg cgcaccucuc                                                   20


<210>  246
<211>  20
<212>  RNA
<213>  Mus musculus

<400>  246
uaaucuccau ccucguccug                                                   20


<210>  247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  247
ugguggccgc ugccaugcug                                                   20


<210>  248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  248
cacgggcgcc cgugcgcagg                                                   20


<210>  249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  249
ugcgcacggg cgcccguggg                                                   20


<210>  250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  250
ugggucccac gggcgcccgu                                                   20


<210>  251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  251
cgcgggcgcc gugcgcagga                                                   20


<210>  252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  252
uccuccugcg cacggcgccc                                                   20


<210>  253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  253
uccugcgcac ggcgcccgcg                                                   20


<210>  254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  254
ugcgcacggc gcccgcggga                                                   20


<210>  255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  255
ugggucccgc gggcgccgug                                                   20


<210>  256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  256
caacgcaagg cuagcaccag                                                   20


<210>  257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  257
uccucgcaac gcaaggcuag                                                   20


<210>  258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  258
ucgcaacgca aggcuagcac                                                   20


<210>  259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  259
cccaggccgu ccuccucgga                                                   20


<210>  260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  260
gaggaggacg gccugggcga                                                   20


<210>  261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  261
ggugcuucgc ccaggccguc                                                   20


<210>  262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  262
gugcucgggu gcuucgccca                                                   20


<210>  263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  263
gugguuccgu gcucgggugc                                                   20


<210>  264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  264
caucccuaca ccugcaccuu                                                   20


<210>  265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  265
cuacaccugc accuuggcgc                                                   20


<210>  266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  266
ccuccgucag caccaccacg                                                   20


<210>  267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  267
gucagcacca ccacguaggu                                                   20


<210>  268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  268
uccgucagca ccaccacgua                                                   20


<210>  269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  269
gagcgcacug ccugccgccu                                                   20


<210>  270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  270
ugguggggua uccccggcgg                                                   20


<210>  271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  271
uggugcggua uccccggcgg                                                   20


<210>  272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  272
agcaggucgc cucucaucuu                                                   20


<210>  273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  273
caucuucacc aggaagccag                                                   20


<210>  274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  274
ccucucaucu ucaccaggaa                                                   20


<210>  275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  275
uggugaagau gagaggcgac                                                   20


<210>  276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  276
aaguugguga ccaugacccu                                                   20


<210>  277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  277
ccaacuucga gaaugugccc                                                   20


<210>  278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  278
cgaaguuggu gaccaugacc                                                   20


<210>  279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  279
ggcacauucu cgaaguuggu                                                   20


<210>  280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  280
uggucaccaa cuucgagaau                                                   20


<210>  281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  281
guggaggcgg gucccguccu                                                   20


<210>  282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  282
cacuugcugg ccugcuagac                                                   20


<210>  283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  283
ucuagcaggc cagcaagugu                                                   20


<210>  284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  284
uuguguucgu cuagcaggcc                                                   20


<210>  285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  285
acacagcggc caaagauggu                                                   20


<210>  286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  286
uuggccgcug uguggaccuc                                                   20


<210>  287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  287
agccacugca gcaccugcuu                                                   20


<210>  288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  288
uuggugccuc cagccacugc                                                   20


<210>  289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  289
agcuacugca gcaccugcuu                                                   20


<210>  290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  290
uuggugccuc cagcuacugc                                                   20


<210>  291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  291
caggcugcug cccacauggc                                                   20


<210>  292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  292
gcacacucgg ggccugcacg                                                   20


<210>  293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  293
gggccugcac ggauggccac                                                   20


<210>  294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  294
gugcaggccc cgagugugcu                                                   20


<210>  295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  295
acagccgucg cccgcugcgc                                                   20


<210>  296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  296
gggccuacac ggauguccac                                                   20


<210>  297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  297
ccugcugcgc cccagaugag                                                   20


<210>  298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  298
ggggcgcagc aggcgacggc                                                   20


<210>  299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  299
ucaucugggg cgcagcaggc                                                   20


<210>  300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  300
ucuggggcgc agcaggcgac                                                   20


<210>  301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  301
augcgcucgc cccgccgcuu                                                   20


<210>  302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  302
cuuccaugcg cucgccccgc                                                   20


<210>  303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence to human PCSK9 variant

<400>  303
cggccccuug gcuggugcug                                                   20


<210>  304
<211>  57
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  304

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Ser 
    50                  55          


<210>  305
<211>  76
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  305

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Gln Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  306
<211>  76
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  306

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Trp Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  307
<211>  72
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  307

Met Ala Gln Ile Asn Asn Met Ala Gln Gly Ile Gln Thr Leu Asn Pro 
1               5                   10                  15      


Asn Ser Asn Phe His Lys Pro Gln Val Pro Lys Ser Ser Ser Phe Leu 
            20                  25                  30          


Val Phe Gly Ser Lys Lys Leu Lys Asn Ser Ala Asn Ser Met Leu Val 
        35                  40                  45              


Leu Lys Lys Asp Ser Ile Phe Met Gln Leu Phe Cys Ser Phe Arg Ile 
    50                  55                  60                  


Ser Ala Ser Val Ala Thr Ala Cys 
65                  70          


<210>  308
<211>  69
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  308

Met Ala Ala Leu Val Thr Ser Gln Leu Ala Thr Ser Gly Thr Val Leu 
1               5                   10                  15      


Ser Val Thr Asp Arg Phe Arg Arg Pro Gly Phe Gln Gly Leu Arg Pro 
            20                  25                  30          


Arg Asn Pro Ala Asp Ala Ala Leu Gly Met Arg Thr Val Gly Ala Ser 
        35                  40                  45              


Ala Ala Pro Lys Gln Ser Arg Lys Pro His Arg Phe Asp Arg Arg Cys 
    50                  55                  60                  


Leu Ser Met Val Val 
65                  


<210>  309
<211>  77
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  309

Met Ala Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe 
1               5                   10                  15      


Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe 
            20                  25                  30          


Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu 
        35                  40                  45              


Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val 
    50                  55                  60                  


Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Cys 
65                  70                  75          


<210>  310
<211>  57
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  310

Met Ala Ser Ser Val Leu Ser Ser Ala Ala Val Ala Thr Arg Ser Asn 
1               5                   10                  15      


Val Ala Gln Ala Asn Met Val Ala Pro Phe Thr Gly Leu Lys Ser Ala 
            20                  25                  30          


Ala Ser Phe Pro Val Ser Arg Lys Gln Asn Leu Asp Ile Thr Ser Ile 
        35                  40                  45              


Ala Ser Asn Gly Gly Arg Val Gln Cys 
    50                  55          


<210>  311
<211>  72
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  311

Met Gly Ala Ala Ala Thr Ser Met Gln Ser Leu Lys Phe Ser Asn Arg 
1               5                   10                  15      


Leu Val Pro Pro Ser Arg Arg Leu Ser Pro Val Pro Asn Asn Val Thr 
            20                  25                  30          


Cys Asn Asn Leu Pro Lys Ser Ala Ala Pro Val Arg Thr Val Lys Cys 
        35                  40                  45              


Cys Ala Ser Ser Trp Asn Ser Thr Ile Asn Gly Ala Ala Ala Thr Thr 
    50                  55                  60                  


Asn Gly Ala Ser Ala Ala Ser Ser 
65                  70          


<210>  312
<211>  20
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, His or Arg

<400>  312

Gly Leu Phe Xaa Ala Leu Leu Xaa Leu Leu Xaa Ser Leu Trp Xaa Leu 
1               5                   10                  15      


Leu Leu Xaa Ala 
            20  


<210>  313
<211>  20
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  313

Gly Leu Phe His Ala Leu Leu His Leu Leu His Ser Leu Trp His Leu 
1               5                   10                  15      


Leu Leu His Ala 
            20  


<210>  314
<211>  9
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  314

His His His His His His His His His 
1               5                   


<210>  315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  315
gaaucaucag aaugucauag                                                   20


<210>  316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  316
ucagaauguc auagagaaau                                                   20


<210>  317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  317
gaaugucaua gagaaauaau                                                   20


<210>  318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  318
aaaggaucag aaucuaguuu                                                   20


<210>  319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  319
uuuugauuau uucucuauga                                                   20


<210>  320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  320
gaaucuaguu uaaaagaguu                                                   20


<210>  321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  321
aguuuaaaag aguuaauuca                                                   20


<210>  322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  322
ucagcuuugc gcuugaauua                                                   20


<210>  323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  323
gggaaacaca gacucuaaau                                                   20


<210>  324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  324
cugugguaag aauuaggaug                                                   20


<210>  325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  325
ccuacacaua aaaaguugua                                                   20


<210>  326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  326
uaggagagga augaacuuaa                                                   20


<210>  327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  327
ucuuccagaa gagcccaguu                                                   20


<210>  328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  328
guguaauugu cccuuacuug                                                   20


<210>  329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  329
acaaauuuaa uguauuuuuc                                                   20


<210>  330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  330
uaacuaagca cuuaccaugc                                                   20


<210>  331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  331
uuugcaauuu aaggugugac                                                   20


<210>  332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  332
agaacuuucu ucuucucacu                                                   20


<210>  333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  333
ugcccacucc aauucauccu                                                   20


<210>  334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  334
uccauguggc accgaguggu                                                   20


<210>  335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  335
uuacagagca cccaccuacc                                                   20


<210>  336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  336
aggcugaggu agucucagau                                                   20


<210>  337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  337
gagacuaccu cagccuggau                                                   20


<210>  338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  338
ccaucugaga cuaccucagc                                                   20


<210>  339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  339
cuaaggcagg ggcaaaaugc                                                   20


<210>  340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  340
agcugcaaau uuucugaacu                                                   20


<210>  341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  341
ccuuucacuc caugucucac                                                   20


<210>  342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  342
uuuuggagcu uuaagauuug                                                   20


<210>  343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  343
uaaagcucca aaaugaucuc                                                   20


<210>  344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  344
agcagggcag ucaaaucuua                                                   20


<210>  345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  345
guuugaaauu auauauuuau                                                   20


<210>  346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  346
uauaaauaua uaauuucaaa                                                   20


<210>  347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  347
uggccaggca caguggcgca                                                   20


<210>  348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  348
caauacuuug ggagguugag                                                   20


<210>  349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  349
acccaccuca accucccaaa                                                   20


<210>  350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  350
cuugagccca ggaguuugag                                                   20


<210>  351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  351
guacaaaaaa aaaaaugcaa                                                   20


<210>  352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  352
uccuauucca cuaauaaaag                                                   20


<210>  353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  353
uaguaaacuu aucuuccuau                                                   20


<210>  354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  354
auucagacgg auuucaccaa                                                   20


<210>  355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  355
gucugaauug auuuaauccu                                                   20


<210>  356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  356
caaaggccgg gcgugguagc                                                   20


<210>  357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  357
aucccaaagg ccgggcgugg                                                   20


<210>  358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  358
uagggugguu gggaggucug                                                   20


<210>  359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  359
auuuccucuu cuaaauuggg                                                   20


<210>  360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  360
uucucuauug cccaggcugg                                                   20


<210>  361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  361
uugccugcuu ucauuuugcc                                                   20


<210>  362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  362
cucccugcca aguacuccuu                                                   20


<210>  363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  363
ccacauaacc uggagcagcu                                                   20


<210>  364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  364
cucccgcagc cugggaaaca                                                   20


<210>  365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  365
uacccuguuu cccaggcugc                                                   20


<210>  366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  366
uuaaaaacuc ugacgccgaa                                                   20


<210>  367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  367
caccaaccag cacuccccac                                                   20


<210>  368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  368
cacccagaaa cagaaaacag                                                   20


<210>  369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  369
ggcucaacca guucugccau                                                   20


<210>  370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  370
gcugacacca cccagacugg                                                   20


<210>  371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  371
aucgagugca gggucugcaa                                                   20


<210>  372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  372
agugcagggu cugcaaaaua                                                   20


<210>  373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  373
ugugacuuag aaugccuaac                                                   20


<210>  374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  374
cauccuguga cuuagaaugc                                                   20


<210>  375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  375
ugugccgacc ucguaucuca                                                   20


<210>  376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  376
acccuuuguu uagcauuuca                                                   20


<210>  377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  377
agaaauaacu auaaaaaugg                                                   20


<210>  378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  378
uguucugucu uggagagcug                                                   20


<210>  379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  379
uggccaggua uccuguucug                                                   20


<210>  380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  380
guuaacaccu uggcauuagg                                                   20


<210>  381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  381
cuacuuagag ggcaaaguaa                                                   20


<210>  382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  382
ugcugccuua uuaauguuug                                                   20


<210>  383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  383
cugaagcacu uuacauaugu                                                   20


<210>  384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  384
uagucagguc uugaagagug                                                   20


<210>  385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  385
agagaacucu uauucacucu                                                   20


<210>  386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  386
acagaugcuu uuggauuugc                                                   20


<210>  387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  387
guagaugaag uuagcaaguu                                                   20


<210>  388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  388
aaaagcaucu guagaugaag                                                   20


<210>  389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  389
ugugcaaaua aucacagucc                                                   20


<210>  390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  390
caguccuauu ucuuccuguu                                                   20


<210>  391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  391
augccagugg acauccuugu                                                   20


<210>  392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  392
uugucucuuu ccucaucuca                                                   20


<210>  393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  393
cagugggaaa acuuucaaua                                                   20


<210>  394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  394
ccgacuuuua gcauccuuau                                                   20


<210>  395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  395
aauagcuugg aaccuuagcc                                                   20


<210>  396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  396
uuguuugugu guguaucuac                                                   20


<210>  397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  397
acaugucuuu guauugcugu                                                   20


<210>  398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  398
uugaagaaga acuuucccau                                                   20


<210>  399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  399
ccaaauaagg aauggcaugc                                                   20


<210>  400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  400
cuagauaacu uccuuuucuu                                                   20


<210>  401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  401
agggauaguu aaggaagaau                                                   20


<210>  402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  402
gguaaagugu aaagugugag                                                   20


<210>  403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  403
ugggaccccc aaaauuacua                                                   20


<210>  404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  404
ucccuucagc cuaguaauuu                                                   20


<210>  405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  405
uagugagacu uugaauagaa                                                   20


<210>  406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  406
aacugccucc uuuggaaagg                                                   20


<210>  407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  407
cauucaguac ucaauucuuu                                                   20


<210>  408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  408
auaaaugccc auaucuaaua                                                   20


<210>  409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  409
aauaguucag gauuucuugc                                                   20


<210>  410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  410
ugaacuauua gauaugggca                                                   20


<210>  411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  411
uaguuaacac auaauucugu                                                   20


<210>  412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  412
aaaaguuagu ucaaauuaca                                                   20


<210>  413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  413
guaauuugaa cuaacuuuug                                                   20


<210>  414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  414
aaacuuuuuc cacauuuuuc                                                   20


<210>  415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  415
gguuuuaaag aauauuuuau                                                   20


<210>  416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  416
agacuaagag cuuuaacuac                                                   20


<210>  417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  417
uuucuacuua auuuacugug                                                   20


<210>  418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  418
aguuuucauu uguuugcugu                                                   20


<210>  419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  419
agcagagaau aaacagcaaa                                                   20


<210>  420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  420
uggccaggcu gguuuugaac                                                   20


<210>  421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  421
ucuuggccag gcugguuuug                                                   20


<210>  422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  422
cagcuacuug ggaggcugag                                                   20


<210>  423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  423
aaaaaguuag uuuaagguua                                                   20


<210>  424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  424
agaacccuaa aaucuaaaaa                                                   20


<210>  425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  425
uuauuuccca agaauuacuc                                                   20


<210>  426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  426
ucuuuauuuc ccaagaauua                                                   20


<210>  427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  427
uuaaaaucau cuuuauuucc                                                   20


<210>  428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  428
accagaaaau augcauugau                                                   20


<210>  429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  429
gcccucuugc augggaaagc                                                   20


<210>  430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  430
gcuguuauaa caucagcccu                                                   20


<210>  431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  431
uuaugcuaca guguguuuuc                                                   20


<210>  432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  432
acuacaacug aauuucuaua                                                   20


<210>  433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  433
aagguugacu uaaagaagca                                                   20


<210>  434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  434
auuugguuuu aggagguuug                                                   20


<210>  435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  435
ucccaauagu aauaauaaua                                                   20


<210>  436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  436
guguuuccuu aaagucuuag                                                   20


<210>  437
<211>  3120
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Stx2 plasmid sequence

<400>  437
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcttccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gtttggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtat tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcagc caaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgccgtcta aaacttacct gagcaagacc ctggctcagt acaccagtaa aacctgtagt     2460

aattgcggct ttaccatcac cagcgccgat tatgaccgcg tgctggaaaa gctgaagaaa     2520

accgccaccg gctggatgac caccatcaat ggtaaagagc ttaaagtcga agggcagatt     2580

acttattaca accgttataa gcggcaaaac gtggtgaaag atctgtcggt tgagctggac     2640

cgtttgtctg aagaaagcgt gaacaatgat atcagctcct ggaccaaagg tcgttccggc     2700

gaagcgttaa gtctgttgaa aaagcgcttt agccatcgcc cggtgcagga aaaattcgtt     2760

tgcctgaact gtggcttcga aacccacgcc gacgagcaag cggcgctcaa tattgcgcgt     2820

agctggctgt tcctgcgcag ccaggaatat aaaaaatatc aaaccaacaa aacaactggc     2880

aataccgaca agcgtgcctt tgttgaaacc tggcagagct tctatcgcaa aaaactgaaa     2940

gaggtctgga aaccggcggt agcgccaaag aaaaaacgca aagtgagcga aaatctttat     3000

tttcaaggta gcgcatggag tcatcctcaa ttcgagaaag gtggaggttc tggcggtgga     3060

tcgggaggtt cagcgtggag ccacccgcag ttcgaaaaag gaaggggatc cggctgctaa     3120


<210>  438
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 119 Variant

<400>  438
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac cagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gttcggcgac     1200

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcat cgaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  439
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 119 Variant

<400>  439

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  440
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 457 Variant

<400>  440
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac aagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcc ccgaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaacccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  441
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 457 Variant

<400>  441

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Pro 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  442
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX 438 Variant

<400>  442
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac cagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgaagc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  443
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX 438 Variant

<400>  443

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  444
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX variant 488

<400>  444
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagttcggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg catcgaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  445
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX variant 488

<400>  445

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  446
<211>  2931
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX variant 491

<400>  446
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcctgcca gcaagaagat cgaccagaac aagctgaagc ccgagatgga cgagaagggc      360

aatctgacca cagccggctt tgcctgctct cagtgtggcc agcctctgtt cgtgtacaag      420

ctggaacagg tgtccgagaa aggcaaggcc tacaccaact acttcggcag atgtaacgtg      480

gccgagcacg agaagctgat tctgctggcc cagctgaaac ctgagaagga ctctgatgag      540

gccgtgacct acagcctggg caagtttgga cagagagccc tggacttcta cagcatccac      600

gtgaccaaag aaagcacaca ccccgtgaag cccctggctc agatcgccgg caatagatac      660

gcctctggac ctgtgggcaa agccctgtcc gatgcctgca tgggaacaat cgccagcttc      720

ctgagcaagt accaggacat catcatcgag caccagaagg tggtcaaggg caaccagaag      780

agactggaaa gcctgaggga gctggccggc aaagagaacc tggaataccc cagcgtgacc      840

ctgcctcctc agcctcacac aaaagaaggc gtggacgcct acaacgaagt gatcgccaga      900

gtgagaatgt gggtcaacct gaacctgtgg cagaagctga aactgtccag ggacgacgcc      960

aagcctctgc tgagactgaa gggcttccct agcttccctc tggtggaaag acaggccaat     1020

gaagtggatt ggtgggacat ggtctgcaac gtgaagaagc tgatcaacga gaagaaagag     1080

gatggcaagg ttttctggca gaacctggcc ggctacaaga gacaagaagc cctgaggcct     1140

tacctgagca gcgaagagga ccggaagaag ggcaagaagt tcgccagata ccagctgggc     1200

gacctgctgc tgcacctgga aaagaagcac ggcgaggact ggggcaaagt gtacgatgag     1260

gcctgggaga gaatcgacaa gaaggtggaa ggcctgagca agcacattaa gctggaagag     1320

gaaagaagga gcgaggacgc ccaatctaaa gccgctctga ccgattggct gagagccaag     1380

gccagctttg tgatcgaggg cctgaaagag gccgacaagg acgagttctg cagatgcgag     1440

ctgaagctgc agaagtggta cggcgatctg agaggcaagc ccttcgccat tgaggccgag     1500

aacagcatcc tggacatcag cggcttcagc aagcagtaca actgcgcctt catttggcag     1560

aaagacggcg tcaagaaact gaacctgtac ctgatcatca attacttcaa aggcggcaag     1620

ctgcggttca agaagatcaa acccgaggcc ttcgaggcta acagattcta caccgtgatc     1680

aacaaaaagt ccggcgagat cgtgcccatg gaagtgaact tcaacttcga cgaccccaac     1740

ctgattatcc tgcctctggc cttcggcaag agacagggca gagagttcat ctggaacgat     1800

ctgctgagcc tggaaaccgg ctctctgaag ctggccaatg gcagagtgat cgagaaaacc     1860

ctgtacaaca ggagaaccag acaggacgag cctgctctgt ttgtggccct gaccttcgag     1920

agaagagagg tgctggacag cagcaacatc aagcccatga acctgatcgg cgtggaccgg     1980

ggcgagaata tccctgctgt gatcgccctg acagaccctg aaggatgccc actgagcaga     2040

ttcaaggact ccctgggcaa ccctacacac atcctgagaa tcggcgagag ctacaaagag     2100

aagcagagga caatccaggc caagaaagag gtggaacaga gaagagccgg cggatactct     2160

aggaagtacg ccagcaaggc caagaatctg gccgacgaca tggtccgaaa caccgccaga     2220

gatctgctgt actacgccgt gacacaggac gccatgctga tcttcgagaa tctgagcaga     2280

ggcttcggcc ggcagggcaa gagaaccttt atggccgaga ggcagtacac cagaatggaa     2340

gattggctca cagctaaact ggcctacgag ggactgagca agacctacct gtccaaaaca     2400

ctggcccagt atacctccaa gacctgcagc aattgcggct tcaccatcac cagcgccgac     2460

tacgacagag tgctggaaaa gctcaagaaa accgccaccg gctggatgac caccatcaac     2520

ggcaaagagc tgaaggttga gggccagatc acctactaca acaggtacaa gaggcagaac     2580

gtcgtgaagg atctgagcgt ggaactggac agactgagcg aagagagcgt gaacaacgac     2640

atcagcagct ggacaaaggg cagatcaggc gaggctctga gcctgctgaa gaagaggttt     2700

agccacagac ctgtgcaaga gaagttcgtg tgcctgaact gcggcttcga gacacacgcc     2760

gatgaacagg ctgccctgaa cattgccaga agctggctgt tcctgagaag ccaagagtac     2820

aagaagtacc agaccaacaa gaccaccggc aacaccgaca agagggcctt tgtggaaacc     2880

tggcagagct tctacagaaa aaagctgaaa gaagtctgga agcccgccgt g              2931


<210>  447
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX variant 491

<400>  447

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  448
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  448

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln 
    210                 215                 220                 


Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu 
            260                 265                 270         


Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys 
        275                 280                 285             


Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr 
    290                 295                 300                 


Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985         


<210>  449
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  449

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val 
            980                 985     


<210>  450
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  450

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  451
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  451

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro His Lys Lys 
            980                 985                 990         


Lys His Pro Asp Ala Ser Val Asn  Phe Ser Glu Phe Ser  Lys 
        995                 1000                 1005     


<210>  452
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  452

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Gln Arg Pro 
            980                 985                 990         


Gly Pro Tyr Asp Arg Pro Gln Arg  Pro Gly Pro Tyr Asp  Arg Pro 
        995                 1000                 1005         


<210>  453
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  453

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Leu Ser Pro 
            980                 985                 990         


Ser Leu Ser Pro Leu Leu Ser Pro  Ser Leu Ser Pro Leu  
        995                 1000                 1005 


<210>  454
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  454

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Arg Gly 
            980                 985                 990         


Lys Gly Gly Lys Gly Leu Gly Lys  Gly Gly Ala Lys Arg  His Arg Lys 
        995                 1000                 1005             


<210>  455
<211>  1013
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  455

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Ser Arg Arg 
            980                 985                 990         


Arg Lys Ala Asn Pro Thr Lys Leu  Ser Glu Asn Ala Lys  Lys Leu Ala 
        995                 1000                 1005             


Lys Glu  Val Glu Asn 
    1010             


<210>  456
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  456

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala 
            980                 985                 990         


Lys Arg Val Lys Leu Asp 
        995             


<210>  457
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  457

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Lys Arg Ser 
            980                 985                 990         


Phe Ser Lys Ala Phe 
        995         


<210>  458
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  458

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Lys Arg Gly 
            980                 985                 990         


Ile Asn Asp Arg Asn Phe Trp Arg  Gly Glu Asn Glu Arg  Lys Thr Arg 
        995                 1000                 1005             


<210>  459
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  459

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Met Gln Glu Ile Lys 
1               5                   10                  15      


Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys 
            20                  25                  30          


Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met 
        35                  40                  45              


Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu 
    50                  55                  60                  


Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys 
65                  70                  75                  80  


Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr 
                85                  90                  95      


Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
            100                 105                 110         


Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
        115                 120                 125             


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
    130                 135                 140                 


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
145                 150                 155                 160 


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
                165                 170                 175     


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val Pro Pro Pro  Pro Lys Lys Lys Arg  Lys Val 
        995                 1000                 1005         


<210>  460
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant

<400>  460

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Met Gln Glu Ile Lys 
1               5                   10                  15      


Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys 
            20                  25                  30          


Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met 
        35                  40                  45              


Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu 
    50                  55                  60                  


Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys 
65                  70                  75                  80  


Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr 
                85                  90                  95      


Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
            100                 105                 110         


Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
        115                 120                 125             


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
    130                 135                 140                 


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
145                 150                 155                 160 


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
                165                 170                 175     


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val Pro Pro Pro  Pro Ala Ala Lys Arg  Val Lys Leu 
        995                 1000                 1005             


Asp 
    


<210>  461
<211>  21
<212>  DNA
<213>  Betapolyomavirus macaca mulatta polyomavirus 1

<400>  461
ccaaagaaga agcggaaggt c                                                 21


<210>  462
<211>  51
<212>  DNA
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  462
cacaagaaga aacatccaga cgcatcagtc aactttagcg agttcagtaa a                51


<210>  463
<211>  54
<212>  DNA
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  463
cagcgccctg ggccttacga taggccgcaa agacccggac cgtatgatcg ccct             54


<210>  464
<211>  48
<212>  DNA
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  464
ctcagcccga gtcttagtcc actgctttcc ccgtccctgt ctccactg                    48


<210>  465
<211>  54
<212>  DNA
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  465
cggggcaagg gtggcaaggg gcttggcaag gggggggcaa agaggcacag gaag             54


<210>  466
<211>  72
<212>  DNA
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  466
agccgccgca gaaaagccaa tcctacaaaa ctgtcagaaa atgcgaaaaa acttgctaag       60

gaggtggaaa ac                                                           72


<210>  467
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  467
cctgccgcaa agcgagtgaa attggac                                           27


<210>  468
<211>  24
<212>  DNA
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  468
aagcggtcct tcagtaaggc cttt                                              24


<210>  469
<211>  57
<212>  DNA
<213>  Alphainfluenzavirus influenza A virus

<400>  469
aaacggggaa taaacgaccg gaacttctgg cgcggggaaa acgagcgcaa aacccga          57


<210>  470
<211>  24
<212>  PRT
<213>  Unknown

<220>  
<223>  nuclear localization signal

<400>  470

Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala Lys 
1               5                   10                  15      


Lys Leu Ala Lys Glu Val Glu Asn 
            20                  


<210>  471
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 387

<400>  471
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca gggagagcaa tcaccctgtg      660

aagcccctgg aacagatcgg cggcaatagc tgtgcctctg gacctgtggg aaaagccctg      720

agcgacgcct gtatgggagc cgtggcatcc ttcctgacca agtaccagga catcatcctg      780

gaacaccaga aagtgatcaa gaagaacgag aaaagactgg ccaacctcaa ggatatcgcc      840

agcgctaacg gcctggcctt tcctaagatc accctgcctc cacagcctca caccaaagag      900

ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga tttgggtcaa cctgaatctg      960

tggcagaagc tgaagatcgg cagggacgaa gccaagccac tgcagagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagttc ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcatcgac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  472
<211>  995
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 387

<400>  472

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg 
        995 


<210>  473
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 395

<400>  473
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagttcggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg catcgaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  474
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 395

<400>  474

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val Thr Ser Pro Lys  Lys Lys Arg Lys Val  
        995                 1000                 1005 


<210>  475
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 485

<400>  475
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggaggaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  476
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 485

<400>  476

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  477
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 486

<400>  477
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctga agcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggaggaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  478
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 486

<400>  478

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  479
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 487

<400>  479
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  480
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 487

<400>  480

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  481
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 488

<400>  481
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagttc ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcatcgac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  482
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 488

<400>  482

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  483
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 489

<400>  483
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggag gaagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  484
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 489

<400>  484

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  485
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 490

<400>  485
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgaagcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggag gaagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  486
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 490

<400>  486

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  487
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 491

<400>  487
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  488
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 491

<400>  488

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  489
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 494

<400>  489
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca gggagagcaa tcaccctgtg      660

aagcccctgg aacagatcgg cggcaatagc tgtgcctctg gacctgtggg aaaagccctg      720

agcgacgcct gtatgggagc cgtggcatcc ttcctgacca agtaccagga catcatcctg      780

gaacaccaga aagtgatcaa gaagaacgag aaaagactgg ccaacctcaa ggatatcgcc      840

agcgctaacg gcctggcctt tcctaagatc accctgcctc cacagcctca caccaaagag      900

ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga tttgggtcaa cctgaatctg      960

tggcagaagc tgaagatcgg cagggacgaa gccaagccac tgcagagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  490
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  CasX Variant 494

<400>  490

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  491
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  T7 promoter primer

<400>  491
gaaattaata cgactcacta ta                                                22


<210>  492
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg2 backbone fwd primer

<400>  492
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaag                                           87


<210>  493
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg2 backbone rev primer

<400>  493
ctttgatgct tcttatttat cggatttctc tccgataaat aagcgcttta cccatacgac       60

atagtcgctg gtgatggc                                                     78


<210>  494
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg2.7.37 spacer primer

<400>  494
cggagcgaga catctcggcc ctttgatgct tcttatttat cggatttctc tccg             54


<210>  495
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg32 backbone fwd primer

<400>  495
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  496
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg32 backbone rev primer

<400>  496
ctttgatgct tccctccgaa gagggcgctt tacccatacg acatag                      46


<210>  497
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg32.7.37 spacer primer

<400>  497
cggagcgaga catctcggcc ctttgatgct tccctccgaa gag                         43


<210>  498
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg64 backbone fwd primer

<400>  498
gaaattaata cgactcacta taggtactgg cgcctttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  499
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg64 backbone rev primer

<400>  499
ctttgatgct tcttacggac cgaagtccgt aagcgcttta cccatacgac atag             54


<210>  500
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg64.7.37 spacer primer

<400>  500
cggagcgaga catctcggcc ctttgatgct tcttacggac cgaag                       45


<210>  501
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg174 backbone fwd primer

<400>  501
gaaattaata cgactcacta taactggcgc ttttatctga ttactttgag agccatcacc       60

agcgactatg tcgtagtggg taaagct                                           87


<210>  502
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg174 backbone rev primer

<400>  502
ctttgatgct ccctccgaag agggagcttt acccactacg acatagtcgc                  50


<210>  503
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sg174.7.37 spacer primer

<400>  503
cggagcgaga catctcggcc ctttgatgct ccctcc                                 36


<210>  504
<211>  130
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  guide RNA

<400>  504
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag ggccgagaug      120

ucucgcuccg                                                             130


<210>  505
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  guide RNA

<400>  505
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgccc ucuucggagg gaagcaucaa agggccgaga ugucucg                    107


<210>  506
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  guide RNA

<400>  506
gguacuggcg ccuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag ggccgagaug ucucgcuccg      120


<210>  507
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  guide RNA

<400>  507
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaagg gccgagaugu cucgcuccg                  109


<210>  508
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  508
gaggaggacg gcctggccga                                                   20


<210>  509
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  509
accgctgcgc caaggtgcgg                                                   20


<210>  510
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  510
gccaggccgt cctcctcgga                                                   20


<210>  511
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  511
gtgctcgggt gcttcggcca                                                   20


<210>  512
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  512
atggccttct tcctggcttc                                                   20


<210>  513
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  513
gcaccaccac gtaggtgcca                                                   20


<210>  514
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  514
tcctggcttc ctggtgaaga                                                   20


<210>  515
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  515
tggcttcctg gtgaagatga                                                   20


<210>  516
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  516
ccaggaagcc aggaagaagg                                                   20


<210>  517
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  517
tccttgcatg gggccaggat                                                   20


<210>  518
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  518
ggcggcaagt tctgctcagc                                                   20


<210>  519
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  519
tctccacgat cgtcagcgtg                                                   20


<210>  520
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  520
acgatcgtca gcgtgagtgc                                                   20


<210>  521
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  521
ctctagcaat ggatcgtggg                                                   20


<210>  522
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  522
caaacaaatg tgtcacaaag                                                   20


<210>  523
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  523
gatgtgtata tcacagacaa                                                   20


<210>  524
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  524
ggaataatgc tgttgttgaa                                                   20


<210>  525
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  525
aaatccagtg acaagtctgt                                                   20


<210>  526
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  526
aggccacagc actgttgctc                                                   20


<210>  527
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  527
agaagacacc ttcttcccca                                                   20


<210>  528
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  528
tccccagccc aggtaagggc                                                   20


<210>  529
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  529
ccagcccagg taagggcagc                                                   20


<210>  530
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  530
agtccctcaa gtccttccag                                                   20


<210>  531
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  531
agcagcagca gcagcagcag                                                   20


<210>  532
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  532
tcagccgccg ccgcaggcac                                                   20


<210>  533
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  533
agggtcgcca tggcggtctc                                                   20


<210>  534
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  534
tcagcttttc cagggtcgcc                                                   20


<210>  535
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  535
gccgcagccg cccccgccgc                                                   20


<210>  536
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  536
gccacagccg ggccgggtgg                                                   20


<210>  537
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  537
tcagccacag ccgggccggg                                                   20


<210>  538
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  538
cggtcggtgc agcggctcct                                                   20


<210>  539
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  539
ccacaccttc actggtccat                                                   20


<210>  540
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  540
taaaggaaag taatggacca                                                   20


<210>  541
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  541
ctggtccatt actttccttt                                                   20


<210>  542
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  542
atgttcatga gtttggagat                                                   20


<210>  543
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  543
tgagtttgga gataatacag                                                   20


<210>  544
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  544
atagacacat cggccacacc                                                   20


<210>  545
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  545
ttattaggca tgttggagac                                                   20


<210>  546
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  546
caggagacca ttgcatcatt                                                   20


<210>  547
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  547
ggcctggagg ctatccagcg                                                   20


<210>  548
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  548
ggccgagatg tctcgctccg                                                   20


<210>  549
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  549
aggccagaaa gagagagtag                                                   20


<210>  550
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  550
cgctggatag cctccaggcc                                                   20


<210>  551
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  551
tgaagctgac agcattcggg                                                   20


<210>  552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  552
gaggaggacg gccuggccga                                                   20


<210>  553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  553
accgcugcgc caaggugcgg                                                   20


<210>  554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  554
gccaggccgu ccuccucgga                                                   20


<210>  555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  555
gugcucgggu gcuucggcca                                                   20


<210>  556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  556
auggccuucu uccuggcuuc                                                   20


<210>  557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  557
gcaccaccac guaggugcca                                                   20


<210>  558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  558
uccuggcuuc cuggugaaga                                                   20


<210>  559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  559
uggcuuccug gugaagauga                                                   20


<210>  560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  560
ccaggaagcc aggaagaagg                                                   20


<210>  561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  561
uccuugcaug gggccaggau                                                   20


<210>  562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  562
ggcggcaagu ucugcucagc                                                   20


<210>  563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  563
ucuccacgau cgucagcgug                                                   20


<210>  564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  564
acgaucguca gcgugagugc                                                   20


<210>  565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  565
cucuagcaau ggaucguggg                                                   20


<210>  566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  566
caaacaaaug ugucacaaag                                                   20


<210>  567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  567
gauguguaua ucacagacaa                                                   20


<210>  568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  568
ggaauaaugc uguuguugaa                                                   20


<210>  569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  569
aaauccagug acaagucugu                                                   20


<210>  570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  570
aggccacagc acuguugcuc                                                   20


<210>  571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  571
agaagacacc uucuucccca                                                   20


<210>  572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  572
uccccagccc agguaagggc                                                   20


<210>  573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  573
ccagcccagg uaagggcagc                                                   20


<210>  574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  574
agucccucaa guccuuccag                                                   20


<210>  575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  575
agcagcagca gcagcagcag                                                   20


<210>  576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  576
ucagccgccg ccgcaggcac                                                   20


<210>  577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  577
agggucgcca uggcggucuc                                                   20


<210>  578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  578
ucagcuuuuc cagggucgcc                                                   20


<210>  579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  579
gccgcagccg cccccgccgc                                                   20


<210>  580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  580
gccacagccg ggccgggugg                                                   20


<210>  581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  581
ucagccacag ccgggccggg                                                   20


<210>  582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  582
cggucggugc agcggcuccu                                                   20


<210>  583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  583
ccacaccuuc acugguccau                                                   20


<210>  584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  584
uaaaggaaag uaauggacca                                                   20


<210>  585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  585
cugguccauu acuuuccuuu                                                   20


<210>  586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  586
auguucauga guuuggagau                                                   20


<210>  587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  587
ugaguuugga gauaauacag                                                   20


<210>  588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  588
auagacacau cggccacacc                                                   20


<210>  589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  589
uuauuaggca uguuggagac                                                   20


<210>  590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  590
caggagacca uugcaucauu                                                   20


<210>  591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  591
ggccuggagg cuauccagcg                                                   20


<210>  592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  592
ggccgagaug ucucgcuccg                                                   20


<210>  593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  593
aggccagaaa gagagaguag                                                   20


<210>  594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  594
cgcuggauag ccuccaggcc                                                   20


<210>  595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  spacer sequence

<400>  595
ugaagcugac agcauucggg                                                   20


<210>  596
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  beta-2 microglobulin (B2M) 7.37 oligonucleotide

<400>  596
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  597
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  beta-2 microglobulin (B2M) 7.37 oligonucleotide

<400>  597
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  598
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  598
gggtcggcat ggcatctcca cctcctcgcg gtccgacctg ggcatccgaa ggaggacgca       60

cgtccactcg gatggctaag ggagagcca                                         89


<210>  599
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  599
ggccggcatg gtcccagcct cctcgctggc gccggctggg caacattccg aggggaccgt       60

cccctcggta atggcgaatg ggaccc                                            86


<210>  600
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  600
gatggccggc atggtcccag cctcctcgct ggcgccggct gggcaacacc ttcgggtggc       60

gaatgggac                                                               69


<210>  601
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  601
ttttggccgg catggtccca gcctcctcgc tggcgccggc tgggcaacat gcttcggcat       60

ggcgaatggg accccggg                                                     78


<210>  602
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  602
cattcctcag aaaatgacaa acctgtgggg cgtaagtaga tcttcggatc tatgatcgtg       60

cagacgttaa aatcaggt                                                     78


<210>  603
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  603
cgtggttagg gccacgttaa atagttgctt aagccctaag cgttgatctt cggatcaggt       60

gcaa                                                                    64


<210>  604
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  604
gggagccccg ctgatgaggt cggggagacc gaaagggact tcggtcccta cggggctccc       60


<210>  605
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  605
cctgtcaccg gatgtgcttt ccggtctgat gagtccgtga ggacgaaaca gg               52


<210>  606
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  606
cgactactga tgagtccgtg aggacgaaac gagtaagctc gtctagtcgc gtgtagcgaa       60

gca                                                                     63


<210>  607
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  607
cgactactga tgagtccgtg aggacgaaac gagtaagctc gtctagtcg                   49


<210>  608
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  608
ccagtactga tgagtccgtg aggacgaaac gagtaagctc gtctactggc gcttttatct       60

cat                                                                     63


<210>  609
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  609
acccgcaagg ccgacggcat ccgccgccgc tggtgcaagt ccagccgccc cttcgggggc       60

gggcgctcat gggtaac                                                      77


<210>  610
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  610
ggcaataaag cggttacaag cccgcaaaaa tagcagagta atgtcgcgat agcgcggcat       60

taatgcagct ttattg                                                       76


<210>  611
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gNA extension

<400>  611
ccacccccac caccaccccc acccccacca ccaccc                                 36


<210>  612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  612
cuauagcaaa cauucuugac                                                   20


<210>  613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  613
acccccugaa guucccauua                                                   20


<210>  614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  614
uuuagccaaa uucauuucuu                                                   20


<210>  615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  615
ucuuuuuucu guaacugcuu                                                   20


<210>  616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  616
ucaugggagg cagagggacc                                                   20


<210>  617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  617
ccauaaaucu ucaugggagg                                                   20


<210>  618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  618
caucucuuac agaggaaaug                                                   20


<210>  619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  619
cuuacagagg aaaugaggca                                                   20


<210>  620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  620
gccuuauauu cccugccucc                                                   20


<210>  621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  621
ugaacaaaga auuggacaaa                                                   20


<210>  622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  622
aaaccccuua augaaucccu                                                   20


<210>  623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  623
acagcugucc cuuuuauuga                                                   20


<210>  624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  624
aucuacagcu gucccuuuua                                                   20


<210>  625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  625
ugucagcgug aggaugaaag                                                   20


<210>  626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  626
ucacgcugac acgauggcug                                                   20


<210>  627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  627
aaucuuguag auugaccacu                                                   20


<210>  628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  628
ccucuugaag cugaaauuuc                                                   20


<210>  629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  629
ccugcucaca ccaccagccc                                                   20


<210>  630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  630
ucagagccca aucagggggu                                                   20


<210>  631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  631
gggggucagu ggagaauggg                                                   20


<210>  632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  632
cccauucucc acugaccccc                                                   20


<210>  633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  633
cugagagcac ggcugagaau                                                   20


<210>  634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  634
cuuuccugag gagguguucc                                                   20


<210>  635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  635
uucccacugc ugccaagcca                                                   20


<210>  636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  636
gaauucucac cugaaguuuu                                                   20


<210>  637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  637
cuugaaccgg gggcggggag                                                   20


<210>  638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  638
cagcuacuca ggaggcugag                                                   20


<210>  639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  639
auuuaacaaa caacuaaggg                                                   20


<210>  640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  640
uuaaacaucu auuuaacaaa                                                   20


<210>  641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  641
ggaagcuucu acagugauug                                                   20


<210>  642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  642
cuguagaagc uuccagauug                                                   20


<210>  643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  643
gcauucaggc cugucaccau                                                   20


<210>  644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  644
gacuuuuuac agaucgggaa                                                   20


<210>  645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  645
guaaaaaguc ggauguccuu                                                   20


<210>  646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  646
ggaaacugag acugggaggg                                                   20


<210>  647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  647
cugaggucac ucuuggaguc                                                   20


<210>  648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  648
acagacccuc ccagcucuua                                                   20


<210>  649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  649
auuucuuacc cacagacugu                                                   20


<210>  650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  650
ucuuggcacc aagucugaug                                                   20


<210>  651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  651
uggcaccaag ucugaugcaa                                                   20


<210>  652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  652
gacuuggugc caagaugauu                                                   20


<210>  653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  653
cagaacagag uguguuuaaa                                                   20


<210>  654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  654
ugguuauuug aauuucucug                                                   20


<210>  655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  655
uuagguggaa auaaaaauuc                                                   20


<210>  656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  656
acagaauucc ucuugccaug                                                   20


<210>  657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  657
uaauuucauc uacagaauuc                                                   20


<210>  658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  658
gcagaccuua agguaggaga                                                   20


<210>  659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  659
ccuaccuuaa ggucugcuga                                                   20


<210>  660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  660
ugggagcccu uuaaaagcag                                                   20


<210>  661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  661
uggccaagca accauaccuc                                                   20


<210>  662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  662
uagcacaaaa guaguaugua                                                   20


<210>  663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  663
gaaguacaac agggaccuag                                                   20


<210>  664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  664
agucccagau gucaagcacc                                                   20


<210>  665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  665
caaacagcuu cuaguagcaa                                                   20


<210>  666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  666
gcuucugccu caagcgggua                                                   20


<210>  667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  667
ccccuaguuu auggggaccu                                                   20


<210>  668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  668
cugggccagg cuggaagcuc                                                   20


<210>  669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  669
ggaggcgggc agcaggcgcu                                                   20


<210>  670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  670
uagcugcuua ggaagcugag                                                   20


<210>  671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  671
cuugaacuca ggaggcagag                                                   20


<210>  672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  672
cggcucauug cacccucugc                                                   20


<210>  673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  673
caggacugcc cuccagccug                                                   20


<210>  674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  674
aguggacauu gaccuucucc                                                   20


<210>  675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  675
ugggggacgg uuggggugga                                                   20


<210>  676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  676
cccacagcag gcagggcaca                                                   20


<210>  677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  677
acauggaagg agcgagaccc                                                   20


<210>  678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  678
ccaaagucaa agagcuagga                                                   20


<210>  679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  679
guccaggggg caagugccuc                                                   20


<210>  680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  680
aaaguuucac cuacugcauc                                                   20


<210>  681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  681
ugaacauuug ccaugcccuu                                                   20


<210>  682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  682
aaaugacaua cugcugugcg                                                   20


<210>  683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  683
cuuccaagug gggcuugccc                                                   20


<210>  684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  684
caaaucccuu ccaagugggg                                                   20


<210>  685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  685
cugaagccuc ucuuuaaggu                                                   20


<210>  686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  686
gugugauccg gggccaggac                                                   20


<210>  687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  687
ggacacagag aaggagggag                                                   20


<210>  688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  688
ccuucgcucc accaagcgaa                                                   20


<210>  689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  689
ggugccugag ggccccagcc                                                   20


<210>  690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  690
cagggccacc ucgaugggac                                                   20


<210>  691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  691
agguggcccu gggaugcugg                                                   20


<210>  692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  692
ccucuccaga gaccuguacu                                                   20


<210>  693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  693
cccuaagcuu uaacuuccuc                                                   20


<210>  694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  694
cugcccucag gaagcuccua                                                   20


<210>  695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  695
ugaguguaag uccccuuagu                                                   20


<210>  696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  696
gcccucuaag caaacuuccu                                                   20


<210>  697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  697
cagcagguga cagcuggcag                                                   20


<210>  698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  698
ucauuuuacg gaugaggaga                                                   20


<210>  699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  699
guaaaaugag gauaauauuu                                                   20


<210>  700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  700
gcaaggaugc ugggagcuca                                                   20


<210>  701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  701
uugcagauga gggcaggaca                                                   20


<210>  702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  702
cagcuuccuc ggcugucuuc                                                   20


<210>  703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  703
aggaucccau caaucugcuc                                                   20


<210>  704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  704
uggauuugaa ccccagccug                                                   20


<210>  705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  705
caucaaucug cuccgucacc                                                   20


<210>  706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  706
aucugcuccg ucacccuggu                                                   20


<210>  707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  707
gcuccgucac ccuggucugu                                                   20


<210>  708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  708
cagaccaggg ugacggagca                                                   20


<210>  709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  709
accacuucua ucucuggaca                                                   20


<210>  710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  710
gguaaguugu aagcucucca                                                   20


<210>  711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  711
cuggagguau gcaaguagag                                                   20


<210>  712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  712
cuacuugcau accuccaggg                                                   20


<210>  713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  713
cuuggcagac aucauaucaa                                                   20


<210>  714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  714
uaucaaaauc uaaagcaucc                                                   20


<210>  715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  715
ccacuuacga ggaagccgug                                                   20


<210>  716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  716
acuuggcucc agggcuuccu                                                   20


<210>  717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  717
agggaugccc ugcucagcac                                                   20


<210>  718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  718
cucgauccac uuggcuccag                                                   20


<210>  719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  719
gccuugcucu ugaugccguu                                                   20


<210>  720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  720
agagcaaggc ugaugcucuc                                                   20


<210>  721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  721
uaucuaaaaa aaaaaaaaag                                                   20


<210>  722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  722
cacuguguca cccaggcugg                                                   20


<210>  723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  723
ugacucgcug cagccucuuc                                                   20


<210>  724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  724
cuugagccug ggaggaagag                                                   20


<210>  725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  725
ucccaccuca gccucccaag                                                   20


<210>  726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  726
uagugacuug gacaagugau                                                   20


<210>  727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  727
cuuguccaag ucacuaagau                                                   20


<210>  728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  728
guaaaauggg aauugaggau                                                   20


<210>  729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  729
ucaauuccca uuuuacagau                                                   20


<210>  730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  730
gcucuuugag ggaauccuca                                                   20


<210>  731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  731
ucacaaauca gcucuuugag                                                   20


<210>  732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  732
caccuggccu gggcuuucau                                                   20


<210>  733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  733
ugaaagaggc ugagucaggg                                                   20


<210>  734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  734
cagggccucc gcaccugcug                                                   20


<210>  735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  735
uuccgguuag caagccccgu                                                   20


<210>  736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  736
uccuccccag gccugccccu                                                   20


<210>  737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  737
agguccacgc aggcaaggcg                                                   20


<210>  738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  738
uugcgagcgg gcucccauga                                                   20


<210>  739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  739
cgaaagcugg gguuagcgcg                                                   20


<210>  740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  740
uccagcagag ggcgcgcuaa                                                   20


<210>  741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  741
cccgcauuuc acaggcgagg                                                   20


<210>  742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  742
ccuucacauu cacacgcuau                                                   20


<210>  743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  743
gggagguaca uuauuauucc                                                   20


<210>  744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  744
gguuaccuca guuuccuccu                                                   20


<210>  745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  745
ugaccacacu gccccacagu                                                   20


<210>  746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  746
ccucauuugc cuacuguggg                                                   20


<210>  747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  747
gagcgaggga gcacacaggg                                                   20


<210>  748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  748
ggaaggucuu cucgucagcc                                                   20


<210>  749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  749
gcuucauugu gcuggggcuu                                                   20


<210>  750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  750
uggcucauga ggaacguacc                                                   20


<210>  751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  751
gccccagguc uacggcaccu                                                   20


<210>  752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  752
ccaugacgcu gcccauggca                                                   20


<210>  753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  753
ggggcaucau cuggagcaug                                                   20


<210>  754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  754
ucuggagcau gugccagugc                                                   20


<210>  755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  755
ggagcaugug ccagugcuac                                                   20


<210>  756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  756
cuaaauuaca cauaaggcug                                                   20


<210>  757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  757
ucaaugccua gagaggcugg                                                   20


<210>  758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  758
acaguuacuc auuaauaccc                                                   20


<210>  759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  759
aucaacaguu acucauuaau                                                   20


<210>  760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  760
gggccuggag guugccacaa                                                   20


<210>  761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  761
cugcuccuuc augucccacu                                                   20


<210>  762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  762
caccuacaaa gcccagcuca                                                   20


<210>  763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  763
ucucugcuug gugaacucuu                                                   20


<210>  764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  764
ggaauaaugc agaauucaaa                                                   20


<210>  765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  765
cugaaccucg aggacauuau                                                   20


<210>  766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  766
uuaaggcuga auaguauuuc                                                   20


<210>  767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  767
uauggauaga cuauauuuug                                                   20


<210>  768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  768
auaugaugaa auacuauuca                                                   20


<210>  769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  769
gcaagcaaag gagagacagc                                                   20


<210>  770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  770
ccuucguccc ugcugacucu                                                   20


<210>  771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  771
ucuccccaaa ggccaugggc                                                   20


<210>  772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  772
cggcagcaag cccauucucc                                                   20


<210>  773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  773
guacaauggg aauaauaaug                                                   20


<210>  774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  774
uguauucacc gaaacacugu                                                   20


<210>  775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  775
ccaugaaaca aaucauacaa                                                   20


<210>  776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  776
uacaaugaaa uaaauguacu                                                   20


<210>  777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  777
uccuagcugu auaaagagcc                                                   20


<210>  778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  778
agaugaaagu caugagcuac                                                   20


<210>  779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  779
ggauguggcu gaagucaggc                                                   20


<210>  780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  780
caggggccag caaggagcgg                                                   20


<210>  781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  781
cugguuccca gcuucggcug                                                   20


<210>  782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  782
aggccugaac gucgccaggg                                                   20


<210>  783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  783
acaagggcuc agacgagagu                                                   20


<210>  784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  784
cagggugucc cacacccucc                                                   20


<210>  785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  785
gccacaucuc aggguguccc                                                   20


<210>  786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  786
cugugugggg aaacugaggc                                                   20


<210>  787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  787
ucccugugug gggaaacuga                                                   20


<210>  788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  788
uuccuacuac ccaggaaugu                                                   20


<210>  789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  789
agggccuacu guaugccagg                                                   20


<210>  790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  790
cugucuguuu gugaacugag                                                   20


<210>  791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  791
auguacuuau ucauuccauc                                                   20


<210>  792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  792
acauuacuga gcaccaacuu                                                   20


<210>  793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  793
accccugagg agcucugagu                                                   20


<210>  794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  794
acuucuccaa uuauucaggg                                                   20


<210>  795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  795
gaaccagguc acucaucuac                                                   20


<210>  796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  796
gcuguaaacc uaagaaagaa                                                   20


<210>  797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  797
accuucccgg gccucaguuu                                                   20


<210>  798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  798
uacccuaggu cuugcagcua                                                   20


<210>  799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  799
cugagucaga augccugggu                                                   20


<210>  800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  800
uggaaggaag ccaagggggc                                                   20


<210>  801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  801
ccacaugaca gggaggaagc                                                   20


<210>  802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  802
gggcaaaguc uuggaagcgg                                                   20


<210>  803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  803
aucagggcaa agucuuggaa                                                   20


<210>  804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  804
uccaacguug gggcaucaau                                                   20


<210>  805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  805
ggcagcccau aguacagguc                                                   20


<210>  806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  806
cagccuuggg ugucaggcuc                                                   20


<210>  807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  807
uauuuugccu ucaaagguug                                                   20


<210>  808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  808
ggggcccaga gggagcacca                                                   20


<210>  809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  809
uuugugaagg ccagucaggu                                                   20


<210>  810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  810
gcguaacaau agcaucaccc                                                   20


<210>  811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  811
cugcaacgcu ugccugugcc                                                   20


<210>  812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  812
ugggcugggg cacaggcaag                                                   20


<210>  813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  813
uggcagcugc agagaaaaug                                                   20


<210>  814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  814
ccuucccuag gccaggaccc                                                   20


<210>  815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  815
uucacugcag aggcagaaau                                                   20


<210>  816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  816
gaagacucag cugugaccag                                                   20


<210>  817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  817
ucauucaccu gcaaauucuu                                                   20


<210>  818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  818
ugccccgagg gaaggggugg                                                   20


<210>  819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  819
caggagugau uccccacacc                                                   20


<210>  820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  820
cuccugagau ucagcaccac                                                   20


<210>  821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  821
uccugcuggc aggcccagca                                                   20


<210>  822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  822
gcagggggcu ugggguagug                                                   20


<210>  823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  823
cacuccacua ccccaagccc                                                   20


<210>  824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  824
ugcagcaaga gccagggaga                                                   20


<210>  825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  825
gguguguggu cuccccauca                                                   20


<210>  826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  826
gcccaggaag gucccgguug                                                   20


<210>  827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  827
ucgagcguga aaggggccuc                                                   20


<210>  828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  828
aaaugaggua ucuucgagcg                                                   20


<210>  829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  829
uccaaaugag guaucuucga                                                   20


<210>  830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  830
gucauuugca caugagaaag                                                   20


<210>  831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  831
uggaaucuug gaagugaugg                                                   20


<210>  832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  832
uggaagugau ggggguguuu                                                   20


<210>  833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  833
cuuccaagau uccaagauau                                                   20


<210>  834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  834
aacaccccca ucacuuccaa                                                   20


<210>  835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  835
ugucaaugcc cugcagccaa                                                   20


<210>  836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  836
cuccagggcc uuucccucuc                                                   20


<210>  837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  837
cagcccuccc ugggcuccuc                                                   20


<210>  838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  838
caggcuccag aaucagaaag                                                   20


<210>  839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  839
gaaagaccug guuuuaccuu                                                   20


<210>  840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  840
uccccacugc auaaaugugg                                                   20


<210>  841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  841
cccugugcua guguggaggg                                                   20


<210>  842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  842
uccaugacug ccuauugccc                                                   20


<210>  843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  843
gacccaugcu ugucuugggg                                                   20


<210>  844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  844
uuacaaaaug augccagugu                                                   20


<210>  845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  845
ucuuuacaaa augaugccag                                                   20


<210>  846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  846
uuauuacauc aucuuuacaa                                                   20


<210>  847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  847
aaauauauag acucacucac                                                   20


<210>  848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  848
guccacauca aaauauauag                                                   20


<210>  849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  849
gcucucuuuc ucuuaauuau                                                   20


<210>  850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  850
aggaaggagg gaauuaacaa                                                   20


<210>  851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  851
ccacuuucag ucaaugaauu                                                   20


<210>  852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  852
caauucauug acugaaagug                                                   20


<210>  853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  853
ugacaauccu uuucucugcu                                                   20


<210>  854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  854
uuuucucugc ugcuggaggu                                                   20


<210>  855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  855
caggaccacc uccagcagca                                                   20


<210>  856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  856
aguucuggcc aguaagaccu                                                   20


<210>  857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  857
guuggggguc acuuucugaa                                                   20


<210>  858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  858
guuuucaaug ccugcaaagg                                                   20


<210>  859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  859
cuuggaauuu cccucaugac                                                   20


<210>  860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  860
cugugaaucu cuuggaauuu                                                   20


<210>  861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  861
cccagcugcc ccggcuuccc                                                   20


<210>  862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  862
gcagguggug cugauguccc                                                   20


<210>  863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  863
gcaccaccug cagauccccc                                                   20


<210>  864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  864
aggucaucug caugaaaaug                                                   20


<210>  865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  865
gcaugaaaau gaccuugagg                                                   20


<210>  866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  866
ccaaaaccca gcccagcaac                                                   20


<210>  867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  867
gaccuuccuc ccuggcugag                                                   20


<210>  868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  868
cagccaggga ggaaggucag                                                   20


<210>  869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  869
ccuccucguc aggguguuaa                                                   20


<210>  870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  870
ccagcagccc gggccccagg                                                   20


<210>  871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  871
gugcucugag guccagggug                                                   20


<210>  872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  872
ggugcaugcc cuuggggucc                                                   20


<210>  873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  873
aaaggacccc aagggcaugc                                                   20


<210>  874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  874
aaauggccag ucggggugac                                                   20


<210>  875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  875
gaccacucag aucccguccu                                                   20


<210>  876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  876
gaguggucag auggcagccc                                                   20


<210>  877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  877
cguccuuccu cccccuccau                                                   20


<210>  878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  878
aaaacugcuu uagaaagucc                                                   20


<210>  879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  879
uguuggacuu ugcaucuccu                                                   20


<210>  880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  880
ccucagugag gggagaguga                                                   20


<210>  881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  881
cucuccccuc acugaggaga                                                   20


<210>  882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  882
gcagaacagu ggcaaucacu                                                   20


<210>  883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  883
cagcucugcu acaaauucac                                                   20


<210>  884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  884
agaacaugag uucuaauccc                                                   20


<210>  885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  885
ccgccugggu cgugucccau                                                   20


<210>  886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  886
gcugccaagg ccuagcuuuc                                                   20


<210>  887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  887
ccuucccccu uucuucccuc                                                   20


<210>  888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  888
ugaggaggga agaaaggggg                                                   20


<210>  889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  889
cauggccccu cacaggguac                                                   20


<210>  890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  890
cucugguggg uguggugggg                                                   20


<210>  891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  891
cuucugcugg accaggagcu                                                   20


<210>  892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  892
ggcaaagaau gcugggaagg                                                   20


<210>  893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  893
gugguuccca cacuuagggc                                                   20


<210>  894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  894
ccugaggagu uuaugaaaug                                                   20


<210>  895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  895
gcauuucaua aacuccucag                                                   20


<210>  896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  896
ccaggaacug ggcccaggaa                                                   20


<210>  897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  897
gcaauucuca aagcgggagg                                                   20


<210>  898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  898
gaguggugga augaggcugc                                                   20


<210>  899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  899
ccugucccca cugacacauu                                                   20


<210>  900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  900
uucucuuuuc aucauucucu                                                   20


<210>  901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  901
uucucuagug cucuuaucac                                                   20


<210>  902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  902
ccaacuuaua ggcugaacau                                                   20


<210>  903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  903
cuuuucucau gcagcccuca                                                   20


<210>  904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  904
uguucacugc uguaccccaa                                                   20


<210>  905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  905
ccuuccaugu uacagacauu                                                   20


<210>  906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  906
agggagguuu uguucuguuu                                                   20


<210>  907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  907
caaaaagaaa aaaaaugcaa                                                   20


<210>  908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  908
ugggugacaa gagggagacu                                                   20


<210>  909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  909
cgccauugca cuucauccug                                                   20


<210>  910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  910
cagcucacca caaccuccgc                                                   20


<210>  911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  911
cuugaaccug ggaggcggag                                                   20


<210>  912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  912
cagcuacucg guaggcugag                                                   20


<210>  913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  913
ccugaaguca ggaguucaag                                                   20


<210>  914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  914
acccgccuca gccucccaac                                                   20


<210>  915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  915
uaacacguug ggaggcugag                                                   20


<210>  916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  916
cuuccacccu aaaaaaacaa                                                   20


<210>  917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  917
gagcgugcug agaggcuggc                                                   20


<210>  918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  918
aggcuuacuc acccuuuuuc                                                   20


<210>  919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  919
ccagucucca cccucuccuc                                                   20


<210>  920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  920
cccagagucc ccuaaccuca                                                   20


<210>  921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  921
cagugucucc agcugggcca                                                   20


<210>  922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  922
gugguccagu uauaauggug                                                   20


<210>  923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  923
cgagcugcca ccuccaggaa                                                   20


<210>  924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  924
gggccggcuu ccuggaggug                                                   20


<210>  925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  925
gacugaguuc ccgcagcacc                                                   20


<210>  926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  926
cagucgccug ugcucucauc                                                   20


<210>  927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  927
gccucccugu ggacucugag                                                   20


<210>  928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  928
ucagagucca cagggaggca                                                   20


<210>  929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  929
gcccucgccu cauccucaga                                                   20


<210>  930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  930
gagcccacgg ccugcccacu                                                   20


<210>  931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  931
ugcuccagca ccagcaaccc                                                   20


<210>  932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  932
agagaguggg gcacugagag                                                   20


<210>  933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  933
uuguccuucu cuccuccaua                                                   20


<210>  934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  934
uauggaacca cugucaugua                                                   20


<210>  935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  935
cauccccugu gacuugcacg                                                   20


<210>  936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  936
ccugugacuu gcacguauac                                                   20


<210>  937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  937
gggcguauac gugcaaguca                                                   20


<210>  938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  938
caaaagaagu gaauaugccc                                                   20


<210>  939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  939
guuaaggugg ggcagggcau                                                   20


<210>  940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  940
guuaaggcaa ggaccagcca                                                   20


<210>  941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  941
uggcucaaaa agcaccucca                                                   20


<210>  942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  942
uauaaaacgg cccuacccuu                                                   20


<210>  943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  943
cccuucgcug acucucuuuu                                                   20


<210>  944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  944
gugugaagag accaccaaac                                                   20


<210>  945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  945
gaguaacggc accaaauuuc                                                   20


<210>  946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  946
ggggaccucc cuugggagau                                                   20


<210>  947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  947
cccaagggag gucccccgau                                                   20


<210>  948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  948
auccccuguc cuccugcucu                                                   20


<210>  949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  949
ccuguccucc ugcucuuugc                                                   20


<210>  950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  950
uucucaugga gcaaagagca                                                   20


<210>  951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  951
accuacgacc ucagguccuc                                                   20


<210>  952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  952
caccaauuuc aaguccggua                                                   20


<210>  953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  953
cucaaccucu uucuccuuuc                                                   20


<210>  954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  954
uggcgccaca cuucaaucuc                                                   20


<210>  955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  955
cucccuucuc uuaauuucaa                                                   20


<210>  956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  956
augaacccaa aaccccggug                                                   20


<210>  957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  957
uugcagggau gccucucuga                                                   20


<210>  958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  958
cugcaaugau uaaacaccaa                                                   20


<210>  959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  959
gagaggcauc ccugcaauga                                                   20


<210>  960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  960
acucacguuu caaggguguc                                                   20


<210>  961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  961
cuuauuuccg caccccaacc                                                   20


<210>  962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  962
cugugcccca aucccuuauu                                                   20


<210>  963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  963
cuuauuuccg cacccugacc                                                   20


<210>  964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  964
cugugcccca aucccuuauu                                                   20


<210>  965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  965
cuuauuuccg ugucccaacc                                                   20


<210>  966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  966
aaagugccgu uuucuggcca                                                   20


<210>  967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  967
uacaagaccu aaauaauuuu                                                   20


<210>  968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  968
gggaggaauu gcauugggaa                                                   20


<210>  969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  969
uccuucuuuc ccucccgccu                                                   20


<210>  970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  970
gaccuuuccc cuccucccca                                                   20


<210>  971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  971
ccaggccgag cuaaguccca                                                   20


<210>  972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  972
uuuuaucacc uccccuccuc                                                   20


<210>  973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  973
ccuccccucc ucacacccga                                                   20


<210>  974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  974
ggugugagga ggggagguga                                                   20


<210>  975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  975
ggcucacagu uucguuccgu                                                   20


<210>  976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  976
accuuuuuaa gaguaaauug                                                   20


<210>  977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  977
caaaucagau agcauuuagg                                                   20


<210>  978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  978
gauagcauuu aggcucuuuu                                                   20


<210>  979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  979
gauuugggau aaagaaaaag                                                   20


<210>  980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  980
aauauaaaaa uccagcccag                                                   20


<210>  981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  981
agcccaguuc augacucguu                                                   20


<210>  982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  982
acuccugaca uuaaauaaaa                                                   20


<210>  983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  983
uguugugagg uuugagggcu                                                   20


<210>  984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  984
ccagcacaca agaacuucca                                                   20


<210>  985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  985
ggccacuggg ccaaggaaug                                                   20


<210>  986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  986
cgggcugcgg gcauuccuug                                                   20


<210>  987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  987
gugugggacc ccacugaaaa                                                   20


<210>  988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  988
gacuguucaa cucaccuggc                                                   20


<210>  989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  989
gggaaggagu cagucagaga                                                   20


<210>  990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  990
ucucggcuua gcggcugaag                                                   20


<210>  991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  991
ggcaguguca gucuucagcc                                                   20


<210>  992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  992
ccucggaagc ccccagacca                                                   20


<210>  993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  993
cggacgccga gcuuugggua                                                   20


<210>  994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  994
auacggaggc uacucacucc                                                   20


<210>  995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  995
ccaccugccc aguucccuua                                                   20


<210>  996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  996
gcuucccuga cuauuccugg                                                   20


<210>  997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  997
cauugccgcc cuucuuccca                                                   20


<210>  998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  998
aaagccuccu uuguguccuc                                                   20


<210>  999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  999
uauacuugug gguuaaggug                                                   20


<210>  1000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1000
ugcaccccuu accaucucau                                                   20


<210>  1001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1001
cauuaaaacc uaaucacccu                                                   20


<210>  1002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1002
cccuuacccc acucaaugcc                                                   20


<210>  1003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1003
caucccgcag cacgcuuuaa                                                   20


<210>  1004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1004
cgcagcacgc uuuaaaaaga                                                   20


<210>  1005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1005
uuuuaaagcg ugcugcggga                                                   20


<210>  1006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1006
cuugccugcu acagcauggc                                                   20


<210>  1007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1007
ugaacuaacu uguaaggcuu                                                   20


<210>  1008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1008
gcgccuuauc aaccaaauug                                                   20


<210>  1009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1009
accaaauugu uuugccuauc                                                   20


<210>  1010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1010
accccguggu gccaaaccca                                                   20


<210>  1011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1011
ucaauaccug ccucuauaac                                                   20


<210>  1012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1012
agaacagaau aauggguuau                                                   20


<210>  1013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1013
caaacaugcu uucuuuacua                                                   20


<210>  1014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1014
cagccucucu ucacuuucac                                                   20


<210>  1015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1015
agcucagcac auuaccuagg                                                   20


<210>  1016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1016
agcccaaauu ucuuccucau                                                   20


<210>  1017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1017
guuaccuauc uuggcguaau                                                   20


<210>  1018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1018
uggcguaauu cucauaaaaa                                                   20


<210>  1019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1019
uguccgacug aucucucaaa                                                   20


<210>  1020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1020
gucggacacg auuggcaggg                                                   20


<210>  1021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1021
cucaaacccc agcaccuucu                                                   20


<210>  1022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1022
caaacuaugc ucaacucacu                                                   20


<210>  1023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1023
auuuucuucc ucauaccuga                                                   20


<210>  1024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1024
ggccucccac auuauuccug                                                   20


<210>  1025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1025
ggaauaaugu gggaggccag                                                   20


<210>  1026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1026
cucugaucca ccugacauuc                                                   20


<210>  1027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1027
gagagauaca gucguggggg                                                   20


<210>  1028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1028
accugacauu caccccauuu                                                   20


<210>  1029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1029
gggugaggaa caggaaagaa                                                   20


<210>  1030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1030
ugcuugauuu auugauggca                                                   20


<210>  1031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1031
agcaugauca gggugaggaa                                                   20


<210>  1032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1032
auaaaucaag caugaucagg                                                   20


<210>  1033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1033
ccacacacca gcaaaggcag                                                   20


<210>  1034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1034
uggaaaucua uccucaagga                                                   20


<210>  1035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1035
auccucaagg aaauaacuuc                                                   20


<210>  1036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1036
ucaaggaaau aacuucucag                                                   20


<210>  1037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1037
gcuauucuac uacuccucag                                                   20


<210>  1038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1038
cugaggagua guagaauagc                                                   20


<210>  1039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1039
agcucgagga uuugccccac                                                   20


<210>  1040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1040
ucgagcuuga uguguaggga                                                   20


<210>  1041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1041
gacucaggca uguugaguaa                                                   20


<210>  1042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1042
aguaacuaaa auaccuccag                                                   20


<210>  1043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1043
cuucccuucu gucagacaca                                                   20


<210>  1044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1044
gacuguauug aggugggaag                                                   20


<210>  1045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1045
guuaucagac uguauugagg                                                   20


<210>  1046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1046
gccaagcauu uuuucaggcu                                                   20


<210>  1047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1047
cuuacggucc uccgucuuca                                                   20


<210>  1048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1048
cuuucccuuc ucagaauuca                                                   20


<210>  1049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1049
cuacuaucuu cugucuaguc                                                   20


<210>  1050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1050
ucugucuagu cauacuccua                                                   20


<210>  1051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1051
cagcugauau cucccggugg                                                   20


<210>  1052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1052
gcugugaugg cuuggagaaa                                                   20


<210>  1053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1053
cccgguggua ucccaaaacu                                                   20


<210>  1054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1054
caaaacugcc acucuuaacu                                                   20


<210>  1055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1055
uugcuggcag gacuaugcug                                                   20


<210>  1056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1056
ccuuaggcac ucucuaauua                                                   20


<210>  1057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1057
aauuagagag ugccuaagga                                                   20


<210>  1058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1058
aggccaucac caaucauucu                                                   20


<210>  1059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1059
ccaaucauuc uauacgacaa                                                   20


<210>  1060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1060
uucuauacga caaacguuuc                                                   20


<210>  1061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1061
ccacaauauc accccuuacc                                                   20


<210>  1062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1062
ccccuuacca caagaucucc                                                   20


<210>  1063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1063
ugugguaagg ggugauauug                                                   20


<210>  1064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1064
cccuucagcu uaaucucucc                                                   20


<210>  1065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1065
cucccauucu agguucccac                                                   20


<210>  1066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1066
cgcuugaagc agcccugaga                                                   20


<210>  1067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1067
cccauucucu cuccauacca                                                   20


<210>  1068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1068
cauccccugu gacuugcaug                                                   20


<210>  1069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1069
ccugugacuu gcauguauac                                                   20


<210>  1070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1070
gggcguauac augcaaguca                                                   20


<210>  1071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1071
caaaagaagu gaauaugccc                                                   20


<210>  1072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1072
guuaaggugg ggcagggcau                                                   20


<210>  1073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1073
guuaaggcaa ggaccggcca                                                   20


<210>  1074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1074
uggcucaaaa agcaccccca                                                   20


<210>  1075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1075
ggcggguagg agugcggggu                                                   20


<210>  1076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1076
uauaaaacgg ccccacccuu                                                   20


<210>  1077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1077
cccuucgcug acucucuuuu                                                   20


<210>  1078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1078
ggugaaaaua gccauuguaa                                                   20


<210>  1079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1079
guguagggca cuuagcauga                                                   20


<210>  1080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1080
aaacauagaa auaguauagu                                                   20


<210>  1081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1081
cggcucacug caagcucugc                                                   20


<210>  1082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1082
uggcuaacau ggugaaaacc                                                   20


<210>  1083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1083
agaccauccu ggcuaacaug                                                   20


<210>  1084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1084
ccugaccucg ugauccaccc                                                   20


<210>  1085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1085
cgaggucagg agaucgagac                                                   20


<210>  1086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1086
acccgccucg gccucccaaa                                                   20


<210>  1087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1087
cagcacuuug ggaggccgag                                                   20


<210>  1088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1088
agggccgggu gcgguggcuc                                                   20


<210>  1089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1089
cauauagucu cgguguguag                                                   20


<210>  1090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1090
aggucuaacu auaugauauu                                                   20


<210>  1091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1091
uauaguuaga ccuagauggg                                                   20


<210>  1092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1092
auaugucccu ggcaauuuug                                                   20


<210>  1093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1093
gauuacaccg gaagacuuag                                                   20


<210>  1094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1094
gaugacagga acuucaauac                                                   20


<210>  1095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1095
cccagcaggu gaaagggcua                                                   20


<210>  1096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1096
uagugacaag ggcaagagua                                                   20


<210>  1097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1097
ccccuccucc cagcccagac                                                   20


<210>  1098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1098
acccucccca cauccucgua                                                   20


<210>  1099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1099
ucguacuagu uauuguacuc                                                   20


<210>  1100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1100
cacucuacuu aaacucagcc                                                   20


<210>  1101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1101
caguaaaagc guauauaaua                                                   20


<210>  1102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1102
aguauuuuuu aaacaacucu                                                   20


<210>  1103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1103
cuucgucugu gaaauggcaa                                                   20


<210>  1104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1104
uucuccccca gccugccuua                                                   20


<210>  1105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1105
ucucccuacc ugccugccug                                                   20


<210>  1106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1106
cccuaccugc cugccugugc                                                   20


<210>  1107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1107
caggggaagg uggaaaagga                                                   20


<210>  1108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1108
ucuagacaag ggugcagcca                                                   20


<210>  1109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1109
uagugcacag guggaaggcu                                                   20


<210>  1110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1110
aucccuucuc accuccuaag                                                   20


<210>  1111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1111
cuucucaccu ccuaagagau                                                   20


<210>  1112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1112
cuuaggaggu gagaagggau                                                   20


<210>  1113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1113
gcucugggcc aucauccauc                                                   20


<210>  1114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1114
uccaucuucc ugcuucccca                                                   20


<210>  1115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1115
aucuuccugc uuccccaagg                                                   20


<210>  1116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1116
uccugcuucc ccaaggauau                                                   20


<210>  1117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1117
uuggggaagc aggaagaugg                                                   20


<210>  1118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1118
cuuucaaggu uuucccuaua                                                   20


<210>  1119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1119
ccaggaaggc cuguguagag                                                   20


<210>  1120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1120
ccacauggcu aaaucagaac                                                   20


<210>  1121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1121
gaacaccgga ccccagcauc                                                   20


<210>  1122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1122
gacugauuuu ccuuucucac                                                   20


<210>  1123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1123
gucagaugcu gggguccggu                                                   20


<210>  1124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1124
cgagggagca uguccaggag                                                   20


<210>  1125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1125
cugugagucc ccugucauug                                                   20


<210>  1126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1126
acguaauuca augacagggg                                                   20


<210>  1127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1127
ccccuaaguu ccaugugaca                                                   20


<210>  1128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1128
ggugaauggc ucaaacccau                                                   20


<210>  1129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1129
caucugugga caaauacaaa                                                   20


<210>  1130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1130
guggacaaau acaaauacac                                                   20


<210>  1131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1131
gaggcagcag ugggacucug                                                   20


<210>  1132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1132
aagccacuac caguguggcu                                                   20


<210>  1133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1133
auuuuccaaa uagcacucac                                                   20


<210>  1134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1134
ucaaaaauua uaaaucagau                                                   20


<210>  1135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1135
gaucaugucc cucugauaug                                                   20


<210>  1136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1136
gauuuauaau uuuugaggau                                                   20


<210>  1137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1137
ugucccucug auaugguuuc                                                   20


<210>  1138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1138
gagggacaug aucugauuua                                                   20


<210>  1139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1139
cagcuugaau uguauuuccc                                                   20


<210>  1140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1140
ugggggaugg ucuuucccau                                                   20


<210>  1141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1141
cccaugauuc aauuaccucc                                                   20


<210>  1142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1142
ccugagacuu auucacuacc                                                   20


<210>  1143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1143
gauggguuua ucagggguuu                                                   20


<210>  1144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1144
gaucuccuga gacuuauuca                                                   20


<210>  1145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1145
gggguuucca uuuuugcuuc                                                   20


<210>  1146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1146
ugacgggaaa cgaaaggcac                                                   20


<210>  1147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1147
gcagcauaaa aauggacuaa                                                   20


<210>  1148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1148
aguaaauugg uacugagagu                                                   20


<210>  1149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1149
uuuaagcaac accccacucu                                                   20


<210>  1150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1150
cuaugaguau uuuugucaaa                                                   20


<210>  1151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1151
gcccccucug agaccaccuc                                                   20


<210>  1152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1152
caagggcagg ggcaaaaugu                                                   20


<210>  1153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1153
ucucucucaa guucgacguu                                                   20


<210>  1154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1154
gguggaagaa auuucuaagc                                                   20


<210>  1155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1155
ucaaaaccau ggagaaaaug                                                   20


<210>  1156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1156
caggccuaga gccccaggag                                                   20


<210>  1157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1157
agguggaggu ucccaaaccu                                                   20


<210>  1158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1158
aagcauuucc uacgucuucu                                                   20


<210>  1159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1159
cuacuggggc auugccuagu                                                   20


<210>  1160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1160
accauucugg ggucuggagg                                                   20


<210>  1161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1161
acugacaacu ugcacuguuc                                                   20


<210>  1162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1162
gcagacaauc aaugccagcc                                                   20


<210>  1163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1163
augccagccc augaaagcug                                                   20


<210>  1164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1164
gcgugaccug gaugugagau                                                   20


<210>  1165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1165
aggucacgcu gaugcaagag                                                   20


<210>  1166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1166
cacauccagg ucacgcugau                                                   20


<210>  1167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1167
ccuuugacuc cacaucucac                                                   20


<210>  1168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1168
uuuuggagcu uuaaaauuug                                                   20


<210>  1169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1169
aguggugcag ucaaauuuua                                                   20


<210>  1170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1170
cuauuguauc uagaaaguaa                                                   20


<210>  1171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1171
agaaaguaac cagcuugcuu                                                   20


<210>  1172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1172
aaagcaagcu gguuacuuuc                                                   20


<210>  1173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1173
gagacaaggc aagucccuuc                                                   20


<210>  1174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1174
ugccuuccca acagucucuc                                                   20


<210>  1175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1175
uucugccccu gaccccucca                                                   20


<210>  1176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1176
uggggcuggu cuuucccaug                                                   20


<210>  1177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1177
cgagaauagc augggaaaga                                                   20


<210>  1178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1178
uaugagacuu auucacuauc                                                   20


<210>  1179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1179
gaugggauua ucagggguuu                                                   20


<210>  1180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1180
gauccuauga gacuuauuca                                                   20


<210>  1181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1181
caucagaucc uaugagacuu                                                   20


<210>  1182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1182
gggguuucug cuuuuguauc                                                   20


<210>  1183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1183
uuuuuauuuu cucuugcugu                                                   20


<210>  1184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1184
cggcaggagg cgaaaagcac                                                   20


<210>  1185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1185
gcagcaugaa aacgaacuaa                                                   20


<210>  1186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1186
cugggcuguu ccagucuggg                                                   20


<210>  1187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1187
ccaucucaca caguacaugu                                                   20


<210>  1188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1188
cacacaguac auguuugauu                                                   20


<210>  1189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1189
aacauguacu gugugagaug                                                   20


<210>  1190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1190
cugccccugu gcagcccucc                                                   20


<210>  1191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1191
auagaauccc ugccccugug                                                   20


<210>  1192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1192
uguucacugc cauacccagc                                                   20


<210>  1193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1193
agaacagucc cugguacaua                                                   20


<210>  1194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1194
cuagcaccaa gcuagagccu                                                   20


<210>  1195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1195
uuggcauccc uagcaccaag                                                   20


<210>  1196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1196
gucuucccca cgggucguga                                                   20


<210>  1197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1197
gucaccuucc auguagcccc                                                   20


<210>  1198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1198
cacagcuaug ggucagagug                                                   20


<210>  1199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1199
cuguuuaaua gacaagaaaa                                                   20


<210>  1200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1200
ucucuguuua auagacaaga                                                   20


<210>  1201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1201
uuccugucuc auucgcccca                                                   20


<210>  1202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1202
uaaaauaaac auggcuccuc                                                   20


<210>  1203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1203
cggcucaccg caaccucugc                                                   20


<210>  1204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1204
cagcuacuag ggaggcuggg                                                   20


<210>  1205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1205
cuacuaaaau acaaaaauua                                                   20


<210>  1206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1206
auugagguca ggaguucgag                                                   20


<210>  1207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1207
gucugccucg gacucccaaa                                                   20


<210>  1208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1208
cagcauuuug ggaguccgag                                                   20


<210>  1209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1209
uguuuaaaau uguaaaauag                                                   20


<210>  1210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1210
agacucucuu auaauuccau                                                   20


<210>  1211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1211
uauguuguuu augcagagac                                                   20


<210>  1212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1212
cauuucaaua aagugguuac                                                   20


<210>  1213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1213
uaacaugcug uuuaaaaguu                                                   20


<210>  1214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1214
auaacuuuua aacagcaugu                                                   20


<210>  1215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1215
uuccauguca auauauaaac                                                   20


<210>  1216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1216
caccauauga acagacuaaa                                                   20


<210>  1217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1217
gucccuccau ugaugaaugu                                                   20


<210>  1218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1218
auggagggac agauuuuagu                                                   20


<210>  1219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1219
aaacauucau caauggaggg                                                   20


<210>  1220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1220
gccagggugu cauauauuac                                                   20


<210>  1221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1221
aagugagagu uuuauuagag                                                   20


<210>  1222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1222
acauguugca gucggagcca                                                   20


<210>  1223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1223
ggucccgcug cugggagcca                                                   20


<210>  1224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1224
ugggccauug ggccagcucc                                                   20


<210>  1225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1225
uugaauggug gguguacauc                                                   20


<210>  1226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1226
cugggguccu ugcuagauua                                                   20


<210>  1227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1227
agcaaggacc ccagcgaugu                                                   20


<210>  1228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1228
uugugcaaac ggagagcaac                                                   20


<210>  1229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1229
uuaguaccuc uuuguccacu                                                   20


<210>  1230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1230
uaaggaaaua auuaggcaag                                                   20


<210>  1231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1231
aauagcuagg ucaguauaua                                                   20


<210>  1232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1232
cuagucagua gcaaacugug                                                   20


<210>  1233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1233
aauucuggcu guuuuuguac                                                   20


<210>  1234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1234
gggagaaaaa augaguuacg                                                   20


<210>  1235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1235
caguggaagc caagauauua                                                   20


<210>  1236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1236
uggcuuccac ugggauuuac                                                   20


<210>  1237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1237
uuuuuuaaua ucuuggcuuc                                                   20


<210>  1238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1238
uauaaaaauu guccuccuuu                                                   20


<210>  1239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1239
ugauaaggag gaggccuuuc                                                   20


<210>  1240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1240
agaucauaua aaaauugucc                                                   20


<210>  1241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1241
agaagucaug aaauaaaagg                                                   20


<210>  1242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1242
gccuuuuauu ucaugacuuc                                                   20


<210>  1243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1243
aucaacaaac uggaaaauag                                                   20


<210>  1244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1244
acaaacugga aaauagauuu                                                   20


<210>  1245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1245
auuuuccagu uuguugauug                                                   20


<210>  1246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1246
ucaaacaaaa gcuccacagc                                                   20


<210>  1247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1247
aacaaaagcu ccacagccaa                                                   20


<210>  1248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1248
acauuuguuu gucuuugaac                                                   20


<210>  1249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1249
caccaagugc ccagaaggag                                                   20


<210>  1250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1250
uucagaacau ugcugaacac                                                   20


<210>  1251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1251
gucugguucu ggggugaggg                                                   20


<210>  1252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1252
aggacuuugc uucacuacuu                                                   20


<210>  1253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1253
caggggcuug aaaugucaaa                                                   20


<210>  1254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1254
gaauaggcua gguucugcuu                                                   20


<210>  1255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1255
aucagaauag gcuagguucu                                                   20


<210>  1256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1256
ucaauauaga gcauucaugu                                                   20


<210>  1257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1257
auauagagca uucaugugcc                                                   20


<210>  1258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1258
cgaaauucca cuuccaggaa                                                   20


<210>  1259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1259
guuucauaaa uuccuggaag                                                   20


<210>  1260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1260
auagcuguuu gcacauguga                                                   20


<210>  1261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1261
aaguugccau gucuguccuu                                                   20


<210>  1262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1262
gcaaccagaa aaauaaggca                                                   20


<210>  1263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1263
acugccuuau uuuucugguu                                                   20


<210>  1264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1264
cggaauaaaa accacacugg                                                   20


<210>  1265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1265
gacgucuuaa ccuagcccua                                                   20


<210>  1266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1266
uaaacuauuu uuacaauuuu                                                   20


<210>  1267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1267
aaguaguuuu auaaaaguag                                                   20


<210>  1268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1268
ccgaaaagau acccaauaaa                                                   20


<210>  1269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1269
uuucggagau agucuacuuu                                                   20


<210>  1270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1270
gcgccuccau uguuacauag                                                   20


<210>  1271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1271
cuccccuuuc ucuucugaua                                                   20


<210>  1272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1272
gaagagaaag gggagagaua                                                   20


<210>  1273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1273
gucauuggau uuagggacca                                                   20


<210>  1274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1274
aaugacugau aucagaagag                                                   20


<210>  1275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1275
uaaacccagg auaaucuccu                                                   20


<210>  1276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1276
uggguuuagg auggucccua                                                   20


<210>  1277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1277
ccucaugaga uccuuagguc                                                   20


<210>  1278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1278
caugaggaga uuauccuggg                                                   20


<210>  1279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1279
uuaggucaau uacaucugca                                                   20


<210>  1280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1280
gcaaagaucu cauuuccaaa                                                   20


<210>  1281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1281
uugcagaugu aauugaccua                                                   20


<210>  1282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1282
cauuuccaaa uaaggucaca                                                   20


<210>  1283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1283
uuuuggggga cacgauucaa                                                   20


<210>  1284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1284
ugucccccaa aaagauaagu                                                   20


<210>  1285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1285
uccucccacu ccugaaccac                                                   20


<210>  1286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1286
uuucaaacua uucacguuuu                                                   20


<210>  1287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1287
uuuuguguga auguucaauu                                                   20


<210>  1288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1288
acucauucag ucuaugaggg                                                   20


<210>  1289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1289
ucaaggcuuc cucccucuaa                                                   20


<210>  1290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1290
cuaaaugccu cuuccugagu                                                   20


<210>  1291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1291
ccucuccucc ucuuaucccu                                                   20


<210>  1292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1292
ccuaccucca cuaucuccuc                                                   20


<210>  1293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1293
cugcggaggc cagauugggg                                                   20


<210>  1294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1294
ggccuccgca gggaucaccu                                                   20


<210>  1295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1295
ucuuauacuc agcugacacu                                                   20


<210>  1296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1296
uuuuccccuc cugccuuccu                                                   20


<210>  1297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1297
ggguaaguca gaagccucuu                                                   20


<210>  1298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1298
cucaccaauu accccuccca                                                   20


<210>  1299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1299
uccacugcac ucuuaugagg                                                   20


<210>  1300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1300
cauauccucc acugcacucu                                                   20


<210>  1301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1301
gucgcagagc ccagggugcu                                                   20


<210>  1302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1302
augucccucu gugcacaggc                                                   20


<210>  1303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1303
uucucugggu gcacgguaac                                                   20


<210>  1304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1304
auucuugcuc caggggaggc                                                   20


<210>  1305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1305
aaggccuccc cuggagcaag                                                   20


<210>  1306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1306
cagcacagag uaggagcuca                                                   20


<210>  1307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1307
agcccgccau cgcagcacag                                                   20


<210>  1308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1308
ccaucgagcc cgccaucgca                                                   20


<210>  1309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1309
acuuuggacu ccagcaccua                                                   20


<210>  1310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1310
aggugcugga guccaaaguu                                                   20


<210>  1311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1311
gcugugcauc ugcaagggag                                                   20


<210>  1312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1312
gcaagggagg aucauaaauu                                                   20


<210>  1313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1313
ucccuugcag augcacagca                                                   20


<210>  1314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1314
uaaauucgcc uuuguuucuu                                                   20


<210>  1315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1315
acagcccuuc cagaaagagc                                                   20


<210>  1316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1316
gaggccagga gcucucuuuc                                                   20


<210>  1317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1317
uccugccugg uacacaauag                                                   20


<210>  1318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1318
aguaaacacc uauuguguac                                                   20


<210>  1319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1319
acuggacaag cauccaguaa                                                   20


<210>  1320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1320
uugcaaauug aaucuucugg                                                   20


<210>  1321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1321
ucuggaaagc ugagcuugug                                                   20


<210>  1322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1322
uuguaguaua aaucccuuga                                                   20


<210>  1323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1323
cuugaaaugc auguaggcug                                                   20


<210>  1324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1324
aaagcaagca aucucuucaa                                                   20


<210>  1325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1325
cuucaaggag cagcuaguug                                                   20


<210>  1326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1326
uacuguggac uccucgcugc                                                   20


<210>  1327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1327
auccuacugu ggacuccucg                                                   20


<210>  1328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1328
cacgcagggu gagaggcggg                                                   20


<210>  1329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1329
uaacugggcu ggaaggcagg                                                   20


<210>  1330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1330
gacgcuguuu ggggagggcg                                                   20


<210>  1331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1331
gguuucggcc ucgcccuccc                                                   20


<210>  1332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1332
uccaguccgg ggguuccguu                                                   20


<210>  1333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1333
gauaggaucg uccgaugggg                                                   20


<210>  1334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1334
gauuaaacau uaacggaacc                                                   20


<210>  1335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1335
uaucugauua aacauuaacg                                                   20


<210>  1336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1336
uccgaugggg cucugguggc                                                   20


<210>  1337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1337
gacgauccua ucugauuaaa                                                   20


<210>  1338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1338
cgccaccaga gccccaucgg                                                   20


<210>  1339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1339
gcgcgcccca ggcgucaagc                                                   20


<210>  1340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1340
uggcugggag cugggagccg                                                   20


<210>  1341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1341
cuacacccgc accuuggcgc                                                   20


<210>  1342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1342
ugccaagcga agagcccucg                                                   20


<210>  1343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1343
uggggacugc aggcaaggcg                                                   20


<210>  1344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1344
uggcagugcu cugcucgccc                                                   20


<210>  1345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1345
ugcccagauu ucccaguuuc                                                   20


<210>  1346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1346
gggcaggaua uccuggcagu                                                   20


<210>  1347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1347
gaacccacua uaauggcaag                                                   20


<210>  1348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1348
gccguccuuc ccaccccgcc                                                   20


<210>  1349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1349
guuucagccg aagaaaagaa                                                   20


<210>  1350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1350
gacuccaagc ugggggacac                                                   20


<210>  1351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1351
uggcuuccuc ucacuagcug                                                   20


<210>  1352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1352
uugagccucc auugccuaau                                                   20


<210>  1353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1353
uuaaaaggga ggugacaauc                                                   20


<210>  1354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1354
ucccuacggc ucaguggcag                                                   20


<210>  1355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1355
gcugccacug agccguaggg                                                   20


<210>  1356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1356
ccccaucugc ugccacugag                                                   20


<210>  1357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1357
ccccggggcu ugcauuguaa                                                   20


<210>  1358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1358
cuugcaguuu ugucccuguc                                                   20


<210>  1359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1359
ugccacccag cacacucaga                                                   20


<210>  1360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1360
cucgagaaag ucaaaggcuc                                                   20


<210>  1361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1361
uggccacaac cccacaacau                                                   20


<210>  1362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1362
ugagagguga guaagcagag                                                   20


<210>  1363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1363
ucaagggcuu gguucaggug                                                   20


<210>  1364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1364
aauuuagaau gaaaauauuu                                                   20


<210>  1365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1365
uuuucuuuua gucaugagaa                                                   20


<210>  1366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1366
gaaaaugccu uccgcuaaau                                                   20


<210>  1367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1367
cugaacuccu acuaaugcuu                                                   20


<210>  1368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1368
ucgcugaacu ccuacuaaug                                                   20


<210>  1369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1369
uagaauaaaa uucucaugac                                                   20


<210>  1370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1370
uuguucaugg uaccuccuaa                                                   20


<210>  1371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1371
uccaccucug guuuucccag                                                   20


<210>  1372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1372
caaaaaaaaa agaaaaagaa                                                   20


<210>  1373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1373
gucucccggg uucaaguggu                                                   20


<210>  1374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1374
cagcuucuug ggaggcugag                                                   20


<210>  1375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1375
acugaggagg ucaggaguuu                                                   20


<210>  1376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1376
gaggagguga uccucccgcc                                                   20


<210>  1377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1377
ccuccucgga uccacugagg                                                   20


<210>  1378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1378
ucccgccuca gccucccaaa                                                   20


<210>  1379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1379
accgucugaa auguaaaaug                                                   20


<210>  1380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1380
caaaaaaaac uuuugguuuu                                                   20


<210>  1381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1381
aauaaaucac aaaaaaaacu                                                   20


<210>  1382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1382
caugucaguu cacgucaggu                                                   20


<210>  1383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1383
augcagcaaa auauaugaau                                                   20


<210>  1384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1384
ggagcugcau acuguaaucu                                                   20


<210>  1385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1385
gagucugcuu ggaagaaucu                                                   20


<210>  1386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1386
aaacaaguuc ugagguucaa                                                   20


<210>  1387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1387
uggacuccag ucagaguaga                                                   20


<210>  1388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1388
cuguauauau gcaucuugga                                                   20


<210>  1389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1389
cccauaucuc uguauauaug                                                   20


<210>  1390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1390
aguccaaacu ccaugcuccu                                                   20


<210>  1391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1391
ccauagauag uggcugcuau                                                   20


<210>  1392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1392
auggugauuu guuugguuuu                                                   20


<210>  1393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1393
cauguggaaa uuugguccuc                                                   20


<210>  1394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1394
caaggacggc accaagccuu                                                   20


<210>  1395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1395
uagcgggaga acuuacucau                                                   20


<210>  1396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1396
gccuucaagg gaaaucauag                                                   20


<210>  1397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1397
cauggcaaga gaagaagcaa                                                   20


<210>  1398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1398
aucacauggc aagagaagaa                                                   20


<210>  1399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1399
cugcacaugu aggcuccccu                                                   20


<210>  1400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1400
gugaaagcag cuuaaggccc                                                   20


<210>  1401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1401
gcuucuggug agggccuuaa                                                   20


<210>  1402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1402
ugagcugaau aaaucccuuu                                                   20


<210>  1403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1403
cuuuuccuug uaaauuacuc                                                   20


<210>  1404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1404
cuucugccug cauuuguaga                                                   20


<210>  1405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1405
ggaugggaga uuuauauaac                                                   20


<210>  1406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1406
agaugcucua caaaugcagg                                                   20


<210>  1407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1407
cccauccaga ugcucuacaa                                                   20


<210>  1408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1408
gaggcuccga gagguugagu                                                   20


<210>  1409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1409
ugggcuuugg agccaggaaa                                                   20


<210>  1410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1410
ucuacuauac ucuguugugu                                                   20


<210>  1411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1411
acuauacucu guugugucuc                                                   20


<210>  1412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1412
caccccuacu uacaaauuac                                                   20


<210>  1413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1413
uguuccuccu ugcauggggc                                                   20


<210>  1414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1414
uggccccaug caaggaggaa                                                   20


<210>  1415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1415
guggagguug ccuggcaccu                                                   20


<210>  1416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1416
ccggcgggca gccugggccu                                                   20


<210>  1417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1417
uggugaggua uccccggcgg                                                   20


<210>  1418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1418
ugcaugucuu ccauggccuu                                                   20


<210>  1419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1419
ucaccaggaa gccaggaaga                                                   20


<210>  1420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1420
ggaagugcca uucccaaaaa                                                   20


<210>  1421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1421
gaaggggaca gcaaguaugu                                                   20


<210>  1422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1422
gguaccaagc acaguaacua                                                   20


<210>  1423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1423
ucauuugaaa gacgaggaga                                                   20


<210>  1424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1424
aggcucuacc ccuagcuguc                                                   20


<210>  1425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1425
aacccauugg ucugccugcc                                                   20


<210>  1426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1426
gcugccuacg gaaaccugua                                                   20


<210>  1427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1427
cagggccuug ucccuacagg                                                   20


<210>  1428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1428
agagugaagu cccuucuuua                                                   20


<210>  1429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1429
aggagggagg agggccaccc                                                   20


<210>  1430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1430
ucgguggagg ggcagaaagg                                                   20


<210>  1431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1431
uaaaaaaacg uuuuuauuug                                                   20


<210>  1432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1432
aguuagaggc caggaaacga                                                   20


<210>  1433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1433
gugugaaaau gacacacgcu                                                   20


<210>  1434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1434
gcucagcaua ccguggcuga                                                   20


<210>  1435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1435
cugucauggc gccacaggcc                                                   20


<210>  1436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1436
gucugcucaa cacacguuua                                                   20


<210>  1437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1437
ucgccucugc agcacacagu                                                   20


<210>  1438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1438
ggugcuauac ggguaccuuc                                                   20


<210>  1439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1439
agagcuggac uucaaacugg                                                   20


<210>  1440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1440
uaccagccug gguucgaguc                                                   20


<210>  1441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1441
cuucaccucu cugagccuca                                                   20


<210>  1442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1442
guaaaccagu uauaauaauu                                                   20


<210>  1443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1443
gcugaaugcu ucacgaccuc                                                   20


<210>  1444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1444
ccagaggcuu cuuaaccugc                                                   20


<210>  1445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1445
agggacuagu uguggcagga                                                   20


<210>  1446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1446
cccgaggguu caccgcugcc                                                   20


<210>  1447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1447
gccccacucc cucccuaccu                                                   20


<210>  1448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1448
gcaccucugc cucccggguu                                                   20


<210>  1449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1449
cuugaacccg ggaggcagag                                                   20


<210>  1450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1450
cuauuaaaaa uacaaaaauu                                                   20


<210>  1451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1451
ccugaggucg agaguucgag                                                   20


<210>  1452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1452
cccaccucgg ccucccaaag                                                   20


<210>  1453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1453
cagcacuuug ggaggccgag                                                   20


<210>  1454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1454
gcagcuggga gcggugacuc                                                   20


<210>  1455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1455
ugacauaaca gcacuggcaa                                                   20


<210>  1456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1456
ugcccagagc cuuggcacag                                                   20


<210>  1457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1457
ugucugggag ccaggcugug                                                   20


<210>  1458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1458
uuccuaaaag gaauccucua                                                   20


<210>  1459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1459
ucuaugccag accguguugc                                                   20


<210>  1460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1460
cugcaacacg gucuggcaua                                                   20


<210>  1461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1461
ggcugggagc ccagcacucc                                                   20


<210>  1462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1462
aggagcgaga aaacucaggc                                                   20


<210>  1463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1463
cagcccagca gccucccacc                                                   20


<210>  1464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1464
aaccuguccc cacaucccag                                                   20


<210>  1465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1465
gguaaggcca ggcuguggcu                                                   20


<210>  1466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1466
aggaggacuc cucugucuuu                                                   20


<210>  1467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1467
cguggaaccu ggagcggauu                                                   20


<210>  1468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1468
gcuccagguu ccacgggaug                                                   20


<210>  1469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1469
gcccgguacc guggaggggu                                                   20


<210>  1470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1470
gugcccugcc ccaccccauc                                                   20


<210>  1471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1471
gagcugaauc cauuugcucu                                                   20


<210>  1472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1472
auuugcucug cccuggccug                                                   20


<210>  1473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1473
ccauccccug cagcccccac                                                   20


<210>  1474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1474
ccugcagccc ccacugccug                                                   20


<210>  1475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1475
uuuaaggcaa gacuuuugca                                                   20


<210>  1476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1476
ucuuuuccuu cuuuucucuu                                                   20


<210>  1477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1477
gauggugacu cuaccuaggg                                                   20


<210>  1478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1478
gaugaacccu ccuuccaagg                                                   20


<210>  1479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1479
gguccagucu gcagggcacu                                                   20


<210>  1480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1480
uuuaauggga uagacacaac                                                   20


<210>  1481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1481
cauuaaagga ucugguccag                                                   20


<210>  1482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1482
cagacagggu ugugucuauc                                                   20


<210>  1483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1483
agagucuucc ccgacugaau                                                   20


<210>  1484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1484
cugcgcugag cuccagaccu                                                   20


<210>  1485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1485
ucucugcgcu gagcuccaga                                                   20


<210>  1486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1486
cacgagaacc gguaaggggu                                                   20


<210>  1487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1487
ugggaagcca cuuucuucua                                                   20


<210>  1488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1488
uucaacucau uggagucuca                                                   20


<210>  1489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1489
gcacauccuu caacucauug                                                   20


<210>  1490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1490
guugcaaugg cagcaacuca                                                   20


<210>  1491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1491
gagcuggugg gcugggugug                                                   20


<210>  1492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1492
ucuggcaagg guggcagcag                                                   20


<210>  1493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1493
gugccucagg gaccucccgg                                                   20


<210>  1494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1494
gagaccaaga gggacacugg                                                   20


<210>  1495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1495
ucugccagug ucccucuugg                                                   20


<210>  1496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1496
cagagacccc aguccaggca                                                   20


<210>  1497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1497
ucucaguccc ugccuggacu                                                   20


<210>  1498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1498
ugcccccuaa guuaguuucc                                                   20


<210>  1499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1499
acuuguucca accgaggggg                                                   20


<210>  1500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1500
gugucggcag gaccacuuuc                                                   20


<210>  1501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1501
cagccucugu cuucacacag                                                   20


<210>  1502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1502
aaugacaagu guccuuauga                                                   20


<210>  1503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1503
agugggcccu aaauccaaug                                                   20


<210>  1504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1504
uccaggauga ucucaugugg                                                   20


<210>  1505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1505
uggaggaucc agugggcccu                                                   20


<210>  1506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1506
uccuggagga uccagugggc                                                   20


<210>  1507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1507
caugugggga accuuaacca                                                   20


<210>  1508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1508
gcaaggaccc uuuuuccaaa                                                   20


<210>  1509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1509
uaacccccac aaccuguggc                                                   20


<210>  1510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1510
cuuuggcagc cacuguuccc                                                   20


<210>  1511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1511
uauggggaag aaagggcccc                                                   20


<210>  1512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1512
augggcaucc uauggggaag                                                   20


<210>  1513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1513
agggcuuggc uggaggaagu                                                   20


<210>  1514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1514
gagaggguga gugacguaug                                                   20


<210>  1515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1515
ucagguuccu cugcaaaagg                                                   20


<210>  1516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1516
uuaccucccu uuugcagagg                                                   20


<210>  1517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1517
guuauugcug uagcaugcau                                                   20


<210>  1518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1518
cagcaccuca cucaauaccu                                                   20


<210>  1519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1519
ccagcaccua auauggugcc                                                   20


<210>  1520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1520
agaagauuaa uccauuccuu                                                   20


<210>  1521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1521
ucuggauaca cuguuggggg                                                   20


<210>  1522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1522
auuccuuaaa caaaugcuac                                                   20


<210>  1523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1523
gugucaagua gcauuuguuu                                                   20


<210>  1524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1524
agaacuaauc ugugucaagu                                                   20


<210>  1525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1525
agcagaagga ucaggaaagg                                                   20


<210>  1526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1526
uucugcugga uacacaggcu                                                   20


<210>  1527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1527
ggaaaggauu ccuggaggaa                                                   20


<210>  1528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1528
uuuccugauc cuucugcugg                                                   20


<210>  1529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1529
acguucauuc cacugcuugg                                                   20


<210>  1530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1530
gaccuggagg ccacccaggc                                                   20


<210>  1531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1531
uccaaacccc cgggugaggc                                                   20


<210>  1532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1532
gagcugggcc ccuuuccagc                                                   20


<210>  1533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1533
uugggcuucc uuccagugag                                                   20


<210>  1534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1534
gccgcugggg ccacacccca                                                   20


<210>  1535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1535
cugggccugg gguguggccc                                                   20


<210>  1536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1536
ucuugcagca gaacccaggu                                                   20


<210>  1537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1537
ugcagcagaa cccagguaca                                                   20


<210>  1538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1538
gcuccaggag cuguaccugg                                                   20


<210>  1539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1539
agcagaaggc cugcugggca                                                   20


<210>  1540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1540
agaagacagc acagaggcug                                                   20


<210>  1541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1541
aguugucccg ucagccugga                                                   20


<210>  1542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1542
ccugcagcca gcccggggcc                                                   20


<210>  1543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1543
ggccucugcc caccuugcug                                                   20


<210>  1544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1544
agugguuccu cuaggguggc                                                   20


<210>  1545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1545
ggagaccaaa cagugcucgc                                                   20


<210>  1546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1546
accaugugcc cggugcuaca                                                   20


<210>  1547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1547
auaggcaucu accaugugcc                                                   20


<210>  1548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1548
cacagccugg gaggagaggc                                                   20


<210>  1549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1549
gucccguggg cacuuugguu                                                   20


<210>  1550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1550
guggagcuuc cugccgagac                                                   20


<210>  1551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1551
ucccacccac ccacuaugcu                                                   20


<210>  1552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1552
cacaugaauu ucaggcaagg                                                   20


<210>  1553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1553
cagagcagcc acugaauugc                                                   20


<210>  1554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1554
gugggggcca cuauuuagcc                                                   20


<210>  1555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1555
acaaagaccu uuucuccaaa                                                   20


<210>  1556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1556
caagauggca ucaucuggau                                                   20


<210>  1557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1557
ugagaugcuu aauuacaucu                                                   20


<210>  1558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1558
ucuggauuau gcggugggcu                                                   20


<210>  1559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1559
ggauuaugcg gugggcugua                                                   20


<210>  1560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1560
agaugaugcc aucuugagau                                                   20


<210>  1561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1561
caggacuuac agcccaccgc                                                   20


<210>  1562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1562
cccucugccu uucucucaua                                                   20


<210>  1563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1563
ccaccucugu cuccacgugg                                                   20


<210>  1564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1564
caggacaggu gagcaagugu                                                   20


<210>  1565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1565
cuacucugca gcauauuugg                                                   20


<210>  1566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1566
uccaaauaug cugcagagua                                                   20


<210>  1567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1567
cugcgggggc cacagaggug                                                   20


<210>  1568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1568
gaacagcacc ucuguggccc                                                   20


<210>  1569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1569
gagggcagcc cucugggcug                                                   20


<210>  1570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1570
agcaggcugg accugccugg                                                   20


<210>  1571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1571
gugagcucuc ccuacuuucu                                                   20


<210>  1572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1572
aaacugaucc aguuagggau                                                   20


<210>  1573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1573
guuuggauuc uccaagaagc                                                   20


<210>  1574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1574
aguuagggau gauaaagugu                                                   20


<210>  1575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1575
cuaacuggau caguuuggau                                                   20


<210>  1576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1576
ucccuaacug gaucaguuug                                                   20


<210>  1577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1577
uguggagugg agaacgcuug                                                   20


<210>  1578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1578
uguccgagcu gcagcuuccu                                                   20


<210>  1579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1579
cuguuauucu ccuuugaguc                                                   20


<210>  1580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1580
uguugucuuu cuugcagacu                                                   20


<210>  1581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1581
aaguguaaaa uaaagccccu                                                   20


<210>  1582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1582
aacaauaaua ugaauguuca                                                   20


<210>  1583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1583
auaucuaaca auaauaugaa                                                   20


<210>  1584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1584
ugcuccuuca uaugaauauc                                                   20


<210>  1585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1585
gcuggcaaug cuacugccaa                                                   20


<210>  1586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1586
uauucuauaa uguauuucau                                                   20


<210>  1587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1587
ucacacacua cauccuauuc                                                   20


<210>  1588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1588
caggcacugg ugaaagcgcc                                                   20


<210>  1589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1589
ccuagacacc agcauacaga                                                   20


<210>  1590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1590
agggcagggu cauggucacc                                                   20


<210>  1591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1591
gacggccgug cuuaccuguc                                                   20


<210>  1592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1592
ccauccugga gguggguggg                                                   20


<210>  1593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1593
uggagguggg uggggacugc                                                   20


<210>  1594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1594
guugugggaa gggcguucau                                                   20


<210>  1595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1595
auccagccac cugcugauuu                                                   20


<210>  1596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1596
agccaccugc ugauuuguua                                                   20


<210>  1597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1597
gcagguggcu ggauggauga                                                   20


<210>  1598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1598
cggccgcuga ccaccccugc                                                   20


<210>  1599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1599
cuuaccuaug agggugccgc                                                   20


<210>  1600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1600
ggaccuggcc ugggaggugg                                                   20


<210>  1601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1601
gcacucgugg ccacugggaa                                                   20


<210>  1602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1602
ggugaugucu uuaugucuuu                                                   20


<210>  1603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1603
ccggauuuua aaaggggagc                                                   20


<210>  1604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1604
ucaaugugga gggacucgag                                                   20


<210>  1605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1605
ccucgagucc cuccacauug                                                   20


<210>  1606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1606
aagcaaacuu uuucuaucuu                                                   20


<210>  1607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1607
ucugcuugca uaccucugag                                                   20


<210>  1608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1608
gccuggccag ugugaccugc                                                   20


<210>  1609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1609
aaaccuguac ucuguaggaa                                                   20


<210>  1610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1610
auaaccuucu gccccaucag                                                   20


<210>  1611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1611
ggugaccccu ugugccuguc                                                   20


<210>  1612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1612
ccugcuuaca gaggaggaaa                                                   20


<210>  1613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1613
cugugcucag acuggacaca                                                   20


<210>  1614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1614
cagcacuuug ggaggccgag                                                   20


<210>  1615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1615
gcccaccucg gccucccaaa                                                   20


<210>  1616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1616
ccugagguca ggaguucgag                                                   20


<210>  1617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1617
cagcuacuug ggaggcuaag                                                   20


<210>  1618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1618
cuugaaccca ggagguggag                                                   20


<210>  1619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1619
cagcucacug caaccuccac                                                   20


<210>  1620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1620
ugccacugca auccagccug                                                   20


<210>  1621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1621
agccugagug auagagcgag                                                   20


<210>  1622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1622
cucaggcugg auugcagugg                                                   20


<210>  1623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1623
cgcucuauca cucaggcugg                                                   20


<210>  1624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1624
caaaaauaaa uaaguaaaua                                                   20


<210>  1625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1625
cacagccaug cuccuccuag                                                   20


<210>  1626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1626
uuggccacgg cuccuggaga                                                   20


<210>  1627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1627
uagaggccag gauccagaag                                                   20


<210>  1628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1628
uggccucuaa gaugucucca                                                   20


<210>  1629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1629
agaaggcucc cacaccucau                                                   20


<210>  1630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1630
gggccagagc ugcguuaggc                                                   20


<210>  1631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1631
uagcacuuug ggagggcaag                                                   20


<210>  1632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1632
ucccgccuug cccucccaaa                                                   20


<210>  1633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1633
ugaggucagg acaucgagac                                                   20


<210>  1634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1634
agaccauccu ugcuaacacg                                                   20


<210>  1635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1635
uugcuaacac ggugaagccc                                                   20


<210>  1636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1636
cggcucacug caagcuccgc                                                   20


<210>  1637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1637
ugggagcaac ugucccuguu                                                   20


<210>  1638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1638
gagccaggcc ucagagagug                                                   20


<210>  1639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1639
ucuuggugcc ucucuuucau                                                   20


<210>  1640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1640
cuuuccauga aagagaggca                                                   20


<210>  1641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1641
ucacaauaac cuuauuaucc                                                   20


<210>  1642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1642
ccugaguucg uauauucaga                                                   20


<210>  1643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1643
aacuagccaa ccccgggccc                                                   20


<210>  1644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1644
uccaguuugu auuggucaag                                                   20


<210>  1645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1645
uacugguucu gcuucucugc                                                   20


<210>  1646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1646
gcagggcagg ccaggcaggc                                                   20


<210>  1647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1647
aauucugcag gaauugccag                                                   20


<210>  1648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1648
guugaaggcc uuaagagaac                                                   20


<210>  1649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1649
gaagacggag uaaggcaggu                                                   20


<210>  1650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1650
aaaaaauauu uucgcagcag                                                   20


<210>  1651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1651
ggccacaaag uugaucccca                                                   20


<210>  1652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1652
acuuuguggc cugauguuug                                                   20


<210>  1653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1653
ccaaaauuaa ccaucacucu                                                   20


<210>  1654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1654
cucugugccu guaagggagg                                                   20


<210>  1655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1655
ucccggaagu ugccggcagc                                                   20


<210>  1656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1656
ucgcagaguc ugaauagcag                                                   20


<210>  1657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1657
cagagucuga auagcagugg                                                   20


<210>  1658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1658
ccauccccag gcccugcguc                                                   20


<210>  1659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1659
ccaggcccug cguccucugc                                                   20


<210>  1660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1660
acagagugug ccgcaugccc                                                   20


<210>  1661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1661
aggggaagga aucuuguucc                                                   20


<210>  1662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1662
uguuccacuu caagucugga                                                   20


<210>  1663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1663
gcucugcaac ccccaccccc                                                   20


<210>  1664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1664
aggcuucccu ggcggccgaa                                                   20


<210>  1665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1665
agcaaacaaa gcccaacaca                                                   20


<210>  1666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1666
cugccuuguc cucucaguuu                                                   20


<210>  1667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1667
agugguucua agugccacgg                                                   20


<210>  1668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1668
cccccacuag gauguaaacu                                                   20


<210>  1669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1669
uaguggggga gauaggaaac                                                   20


<210>  1670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1670
gacugcccag gcagaacucu                                                   20


<210>  1671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1671
caguuggggc caccaaugcc                                                   20


<210>  1672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1672
uuggugccuc cagcgacugc                                                   20


<210>  1673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1673
caggcugcug cccacguggc                                                   20


<210>  1674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1674
cgguggccga ggcagugggg                                                   20


<210>  1675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1675
cugguccccc ugcacagagc                                                   20


<210>  1676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1676
ggccuacuuc aucucugguc                                                   20


<210>  1677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1677
gacugagugu ccuugaaggc                                                   20


<210>  1678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1678
uggaggaggg acauuugauc                                                   20


<210>  1679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1679
aaugucccuc cuccaagaug                                                   20


<210>  1680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1680
ggagcuugau ggaugaauag                                                   20


<210>  1681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1681
agcucccgau caaauguccc                                                   20


<210>  1682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1682
aucaagcucc cgaucaaaug                                                   20


<210>  1683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1683
gccaggugaa cuccuauuca                                                   20


<210>  1684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1684
ccaucuuuca ccauucaccc                                                   20


<210>  1685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1685
uucaccauuc accccugcac                                                   20


<210>  1686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1686
uggcugcaau gccuggugca                                                   20


<210>  1687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1687
gucucugccu caacucggcc                                                   20


<210>  1688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1688
acuucucugc caaagauguc                                                   20


<210>  1689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1689
uuggcagaga aguggaucag                                                   20


<210>  1690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1690
augaggccug guucccugag                                                   20


<210>  1691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1691
ugcuuaccug ccccaugggu                                                   20


<210>  1692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1692
uccuuacaca gacaagggag                                                   20


<210>  1693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1693
uauuuaaggu ggcgucaucc                                                   20


<210>  1694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1694
uuaguucaug guaggagaga                                                   20


<210>  1695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1695
caggcccuuu uugcagguug                                                   20


<210>  1696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1696
guguaggccc cgagugugcu                                                   20


<210>  1697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1697
ggggcgcagc gggcgacggc                                                   20


<210>  1698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1698
uccagacucc agcucuucug                                                   20


<210>  1699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1699
agcacugucc ugcagccucu                                                   20


<210>  1700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1700
auccagcacu guccugcagc                                                   20


<210>  1701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1701
cugacccuca cgcggcccug                                                   20


<210>  1702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1702
gcuacucugg acucagccau                                                   20


<210>  1703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1703
cuaggccccu cucacucagg                                                   20


<210>  1704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1704
caaaccagca aaaaagugga                                                   20


<210>  1705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1705
auuccacuuu uuugcugguu                                                   20


<210>  1706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1706
acaucaauuc cacuuuuuug                                                   20


<210>  1707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1707
uguagcauca acaucaauuc                                                   20


<210>  1708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1708
gugcacuauc cuguagcauc                                                   20


<210>  1709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1709
gguugcagca uuuuggugga                                                   20


<210>  1710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1710
ccucaagcca gaaaugccug                                                   20


<210>  1711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1711
agccagcucc acuccaccca                                                   20


<210>  1712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1712
uugcuuuggc cuccuggauu                                                   20


<210>  1713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1713
aggaggccaa agcaaggauc                                                   20


<210>  1714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1714
ccauuuugaa accacucugu                                                   20


<210>  1715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1715
gugucccugc caggggccag                                                   20


<210>  1716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1716
acucaagcac ccucaucagu                                                   20


<210>  1717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1717
ugucuagucc cuuucugugu                                                   20


<210>  1718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1718
gcuuuagaau gggcuuugaa                                                   20


<210>  1719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1719
cacuugugag gaccaagccu                                                   20


<210>  1720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1720
augagacuca agccugacuu                                                   20


<210>  1721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1721
cagcuuccuc cuccauaaga                                                   20


<210>  1722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1722
ccuugcaaca caaugaggca                                                   20


<210>  1723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1723
agggcacugg ccuggaguau                                                   20


<210>  1724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1724
caggugcuuu gccuaaggug                                                   20


<210>  1725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1725
cuguaugagg aaaugaugag                                                   20


<210>  1726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1726
uuuccucaua cagagauguu                                                   20


<210>  1727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1727
uuacuauugu uuucaucacc                                                   20


<210>  1728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1728
cccguugcuu uaaaauccag                                                   20


<210>  1729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1729
agccucuggu auaggcaacu                                                   20


<210>  1730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1730
gugacuuccu gcuaccugcc                                                   20


<210>  1731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1731
agggauggug cccugaggcu                                                   20


<210>  1732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1732
cuugaugccc caagaggucc                                                   20


<210>  1733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1733
acucugagcc ucuuauucca                                                   20


<210>  1734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1734
uacaugccag ccugcugugc                                                   20


<210>  1735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1735
auccuacaug ccagccugcu                                                   20


<210>  1736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1736
uuccugaaca uccauccuac                                                   20


<210>  1737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1737
cgcuccccuu uggaagugcu                                                   20


<210>  1738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1738
gcugagcacu uccaaagggg                                                   20


<210>  1739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1739
gacuccauga agcgcaccuc                                                   20


<210>  1740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1740
ucacaguguc ccugugagua                                                   20


<210>  1741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1741
uacaaaugag uaaacagagc                                                   20


<210>  1742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1742
caggccauag agccccugcc                                                   20


<210>  1743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1743
cuggguggaa agaugguguu                                                   20


<210>  1744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1744
uuccacccag agauggagac                                                   20


<210>  1745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1745
cuuuuuuucu uugaguuguu                                                   20


<210>  1746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1746
gacccucucu cuuuaagguc                                                   20


<210>  1747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1747
ccaucagacc cucucucuuu                                                   20


<210>  1748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1748
cagcauuuca caucugagcu                                                   20


<210>  1749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1749
gagcuggcuu uccucugccc                                                   20


<210>  1750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1750
acgcuuccug cugccaugcc                                                   20


<210>  1751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1751
cggccccuca ggagcaggug                                                   20


<210>  1752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1752
ggguggcggu uugccaggua                                                   20


<210>  1753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1753
accuggcaaa ccgccacccu                                                   20


<210>  1754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1754
ggacaaaagc aaaaacagac                                                   20


<210>  1755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1755
guaagguuug cuaccugggu                                                   20


<210>  1756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1756
auaaaugcau gcauauugca                                                   20


<210>  1757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1757
aucaauaaau gcaugcauau                                                   20


<210>  1758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1758
auuuuuuucu gagauggggu                                                   20


<210>  1759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1759
cagaaaaaaa uagaucaauc                                                   20


<210>  1760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1760
ucuggucuca gccuccccaa                                                   20


<210>  1761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1761
caacacuugg ggaggcugag                                                   20


<210>  1762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1762
gagaggccag gugcagcggc                                                   20


<210>  1763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1763
auuuaacaaa ccugcuggga                                                   20


<210>  1764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1764
cggcagggcc uuuucuugcc                                                   20


<210>  1765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1765
acacagacuu gcauuuuaaa                                                   20


<210>  1766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1766
agaccagaau caacacagac                                                   20


<210>  1767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1767
aagaccaaga cugucuuuug                                                   20


<210>  1768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1768
acuugcccug gguacacuga                                                   20


<210>  1769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1769
cuccccagug ccaggaagag                                                   20


<210>  1770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1770
auuuuagugg aggaagacag                                                   20


<210>  1771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1771
uuucaguacu cuauauuaau                                                   20


<210>  1772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1772
caucuuuuca guacucuaua                                                   20


<210>  1773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1773
ccaccugggg gccuuugcuu                                                   20


<210>  1774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1774
cauaacuauu cccaccucuc                                                   20


<210>  1775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1775
aggccagacc acacuccucu                                                   20


<210>  1776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1776
gaaccucuca cuguggccua                                                   20


<210>  1777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1777
cuucucagcu cagcagcuag                                                   20


<210>  1778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1778
acccaccagg ccugcaggcu                                                   20


<210>  1779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1779
ucccccucuc ccacccacau                                                   20


<210>  1780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1780
guccaggggc ccgagccuug                                                   20


<210>  1781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1781
cacuuaaugg caacuccauc                                                   20


<210>  1782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1782
guuucagagg gaugaguuug                                                   20


<210>  1783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1783
cucugaaacu gauggcccca                                                   20


<210>  1784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1784
gucuaucucc acggcccuca                                                   20


<210>  1785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1785
ccacggcccu caaaccaggc                                                   20


<210>  1786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1786
cccaccccgc accucccacc                                                   20


<210>  1787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1787
uucugugagg ccaaagugca                                                   20


<210>  1788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1788
gcugccggag ccggcaccug                                                   20


<210>  1789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1789
caggaugggu gucuggggag                                                   20


<210>  1790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1790
ugggaugggg cugucacugg                                                   20


<210>  1791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1791
ccucgugcca ggccauggag                                                   20


<210>  1792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1792
ccauccccuc gugccaggcc                                                   20


<210>  1793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1793
gcacauuggg agcagcuggc                                                   20


<210>  1794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1794
ucaggucucc accaaggagg                                                   20


<210>  1795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1795
ugccuccuug guggagaccu                                                   20


<210>  1796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1796
augggaagaa uccugccucc                                                   20


<210>  1797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1797
uuggggggug agugugaaag                                                   20


<210>  1798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1798
gcaccuuuca cacucacccc                                                   20


<210>  1799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1799
ccagcuaacu guggagaagc                                                   20


<210>  1800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1800
gggagccccc aggggcuucu                                                   20


<210>  1801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1801
agaaagcuaa gccuccauua                                                   20


<210>  1802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1802
agccagaggc uggagacagg                                                   20


<210>  1803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1803
ccuaggacug acucggcagu                                                   20


<210>  1804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1804
gcguuucugg cucaguuccu                                                   20


<210>  1805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1805
cucaccgagc uuccuggucu                                                   20


<210>  1806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1806
uucugccauc acucaccgag                                                   20


<210>  1807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1807
cccaggccug auucacuggc                                                   20


<210>  1808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1808
ggccugggug auaacggaaa                                                   20


<210>  1809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1809
ccgccaggcc agugaaucag                                                   20


<210>  1810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1810
uuugggucug uccucucugu                                                   20


<210>  1811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1811
ucaaguuaca aaagcaaaac                                                   20


<210>  1812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1812
cccuaggcag ucaagucuau                                                   20


<210>  1813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1813
aauacuuggc uuacucaacu                                                   20


<210>  1814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1814
ugaguacaag uauugggcaa                                                   20


<210>  1815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1815
ccaguacuug cccaauacuu                                                   20


<210>  1816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1816
uaggaaugaa augaaugucu                                                   20


<210>  1817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1817
agagugcugu agggcaccug                                                   20


<210>  1818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1818
ggcacuguaa cuuauuccgu                                                   20


<210>  1819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1819
ugaaaaaagc cauggacuua                                                   20


<210>  1820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1820
gagacuguuc ugaauuuuaa                                                   20


<210>  1821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1821
caguacuuug ggaggcugag                                                   20


<210>  1822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1822
uccugccuca gccucccaaa                                                   20


<210>  1823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1823
uuuaaauuuu uuuauagaga                                                   20


<210>  1824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1824
gccuccugag uagccgggac                                                   20


<210>  1825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1825
ucacugcacu gcagccuggg                                                   20


<210>  1826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1826
cugcacugca gccuggguua                                                   20


<210>  1827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1827
uuaugcacuc uguaacccag                                                   20


<210>  1828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1828
cauucaaugu gggaccucca                                                   20


<210>  1829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1829
caggcaaaau uccucccaga                                                   20


<210>  1830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1830
gggaggaauu uugccugaga                                                   20


<210>  1831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1831
gucaacucuu gaaugcuuuc                                                   20


<210>  1832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1832
cugcccguug gaaccuaggc                                                   20


<210>  1833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1833
aguaucagcu gguuagagau                                                   20


<210>  1834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1834
gcugguuaga gauccacacc                                                   20


<210>  1835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1835
cuaaccagcu gauacuugau                                                   20


<210>  1836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1836
acacccugac agcucuguga                                                   20


<210>  1837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1837
cagagcuguc agggugugga                                                   20


<210>  1838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1838
cuggugacca ccugcuaacc                                                   20


<210>  1839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1839
gggaggaagg gguguggcuu                                                   20


<210>  1840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1840
ggacuagcaa auagggaagg                                                   20


<210>  1841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1841
cacaggucuc agucucauuc                                                   20


<210>  1842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1842
agcaagaagc ccagugugac                                                   20


<210>  1843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1843
ugucgcuggu cacacugggc                                                   20


<210>  1844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1844
augcugggga ccacuuggga                                                   20


<210>  1845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1845
ccaccaaagc uuuuggcucu                                                   20


<210>  1846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1846
accuaaguuc agcauccucc                                                   20


<210>  1847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1847
uccucuaagc uuugcagaug                                                   20


<210>  1848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1848
gcaaagcuua gaggaggaug                                                   20


<210>  1849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1849
ugaaaugguc agccccucca                                                   20


<210>  1850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1850
acagcauuua gcaccaggca                                                   20


<210>  1851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1851
gaacacagcc guagugggcg                                                   20


<210>  1852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1852
acuuccuuuu gaaauuuuau                                                   20


<210>  1853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1853
uguuuauaaa auuucaaaag                                                   20


<210>  1854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1854
aggugugugc aguuaccuuc                                                   20


<210>  1855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1855
gacuuacccu guccugcccc                                                   20


<210>  1856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1856
ucagacuuac ccuguccugc                                                   20


<210>  1857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1857
caccacgacu ucuccuggag                                                   20


<210>  1858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1858
cagcgggcau cucaccacga                                                   20


<210>  1859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1859
ugggaaagaa aacaagcauc                                                   20


<210>  1860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1860
gccaucuuaa gaucggccuc                                                   20


<210>  1861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1861
uaagaucggc cucacuaagg                                                   20


<210>  1862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1862
uaagauggcc gauucugccc                                                   20


<210>  1863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1863
gccucacuaa gggagcuucu                                                   20


<210>  1864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1864
ucauccaaaa aauuggcagu                                                   20


<210>  1865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1865
aaaaaauugg caguaaaaau                                                   20


<210>  1866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1866
gcagguucau ugacuguagc                                                   20


<210>  1867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1867
agugguuacc agcaaaguga                                                   20


<210>  1868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1868
uuuucacuuu gcugguaacc                                                   20


<210>  1869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1869
uguugcuuau auuguugcug                                                   20


<210>  1870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1870
gaagcguaua auauacacgg                                                   20


<210>  1871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1871
uccaccgugu auauuauacg                                                   20


<210>  1872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1872
ugaugaagcu uuacagugag                                                   20


<210>  1873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1873
ggaucgucca ccguguauau                                                   20


<210>  1874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1874
ggagugaaau ugccacuucu                                                   20


<210>  1875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1875
cuggcgacug cacucucagg                                                   20


<210>  1876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1876
ucgcuggcga cugcacucuc                                                   20


<210>  1877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1877
caguguggau caucgccagc                                                   20


<210>  1878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1878
acacugggau aucaucgcug                                                   20


<210>  1879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1879
ucgccagcau uucaagguca                                                   20


<210>  1880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1880
ccagcauuuc aaggucaugu                                                   20


<210>  1881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1881
cuuggugagg augugggcgg                                                   20


<210>  1882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1882
ucaccaagag auuguguggg                                                   20


<210>  1883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1883
cauuucaaac ugcaagacca                                                   20


<210>  1884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1884
ucucagugug uuugacaaag                                                   20


<210>  1885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1885
cauuacugug cucucgccau                                                   20


<210>  1886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1886
gccuggccac augcccacac                                                   20


<210>  1887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1887
gacagugaaa accuggcacu                                                   20


<210>  1888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1888
caccaugcac agaacuaggg                                                   20


<210>  1889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1889
auuuagucgu auuuccaaag                                                   20


<210>  1890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1890
uaaaccuuga cugacuuuuc                                                   20


<210>  1891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1891
uuugcuuuug cuuaaaacau                                                   20


<210>  1892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1892
gcaaucguuu gcuuuugcuu                                                   20


<210>  1893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1893
caugauuuaa gacuacaguu                                                   20


<210>  1894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1894
ugugaucugc aaucguuugc                                                   20


<210>  1895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1895
uuuuaaugcu uggagacaua                                                   20


<210>  1896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1896
uaaagugcuu uuauuuugcu                                                   20


<210>  1897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1897
guuuggggaa caacucauaa                                                   20


<210>  1898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1898
auuacuuaaa gaaguuauga                                                   20


<210>  1899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1899
aauuauauca gaaaaauauc                                                   20


<210>  1900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1900
gaaaaauauc uucaagagcu                                                   20


<210>  1901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1901
ucaagagcuu aguauuuccc                                                   20


<210>  1902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1902
aaaauuggga aauacuaagc                                                   20


<210>  1903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1903
ugauccuggu aaccuuucau                                                   20


<210>  1904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1904
ggaucaaaaa uugggaaaua                                                   20


<210>  1905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1905
ugguaaccuu ucaucaagau                                                   20


<210>  1906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1906
agauccaagc uuaugcauag                                                   20


<210>  1907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1907
ugaugaaagg uuaccaggau                                                   20


<210>  1908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1908
aagcuuaugc auaggguucu                                                   20


<210>  1909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1909
agacccaucu gaaauucuau                                                   20


<210>  1910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1910
gaaauucuau acaaauaggg                                                   20


<210>  1911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1911
uuacaucauu uuaaauugga                                                   20


<210>  1912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1912
uuuuaaauug gauauuccug                                                   20


<210>  1913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1913
aauuuaaaau gauguaaaga                                                   20


<210>  1914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1914
ugcaguaaua uuaaacagga                                                   20


<210>  1915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1915
aaaagcagcu ugcuuuuucu                                                   20


<210>  1916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1916
uagagaaagc aacagcuuua                                                   20


<210>  1917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1917
ccacagaaau gugaauccac                                                   20


<210>  1918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1918
acauauagac cacgcucccg                                                   20


<210>  1919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1919
gcugucccgg gagcgugguc                                                   20


<210>  1920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1920
acaugccgga guucucccac                                                   20


<210>  1921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1921
uguauuucuc aaggaaagca                                                   20


<210>  1922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1922
gcccaaguca cagcagcuuu                                                   20


<210>  1923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1923
ccaggcucuu ccaaaggguu                                                   20


<210>  1924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1924
cgaacccuuu ggaagagccu                                                   20


<210>  1925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1925
gaaucucgaa cccuuuggaa                                                   20


<210>  1926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1926
aguauugugu cuugacuccu                                                   20


<210>  1927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1927
cuagaggaac augcccagcc                                                   20


<210>  1928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1928
acaucaucaa ggucacuucu                                                   20


<210>  1929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1929
ucaaggucac uucucaacuc                                                   20


<210>  1930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1930
aggucacuuc ucaacucacc                                                   20


<210>  1931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1931
ucaugggaga uucugaaccc                                                   20


<210>  1932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1932
ugggagauuc ugaacccugc                                                   20


<210>  1933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1933
cccaugauga uuggugaguu                                                   20


<210>  1934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1934
ggcaacuuaa ugcaauguuu                                                   20


<210>  1935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1935
aaggguaaua aaaugugaua                                                   20


<210>  1936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1936
cauuuuauua cccuuugaua                                                   20


<210>  1937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1937
aauauuugac aauucaugau                                                   20


<210>  1938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1938
ugaauuguca aauauuagau                                                   20


<210>  1939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1939
uagaaaugua cauguuuuac                                                   20


<210>  1940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1940
cauuuaguca gugaaacaac                                                   20


<210>  1941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1941
cugcucugcg uucucacaug                                                   20


<210>  1942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1942
augccucucc cagcuuuauc                                                   20


<210>  1943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1943
guguggccuu uggcuuacac                                                   20


<210>  1944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1944
uucugaauac ucaccgugug                                                   20


<210>  1945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1945
gccccauggc acacggugag                                                   20


<210>  1946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1946
aguuggagcu ggggugggga                                                   20


<210>  1947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1947
aauguacucu cuuccuucca                                                   20


<210>  1948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1948
cagcuacuug ggaggcugag                                                   20


<210>  1949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1949
cuggaaccug ggagaaggag                                                   20


<210>  1950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1950
caccucacug cuaccuccuu                                                   20


<210>  1951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1951
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  1952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1952
gaaaaugggg guggggaggu                                                   20


<210>  1953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1953
agcaccugcg caccucccca                                                   20


<210>  1954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1954
agcaggacug uguugaggau                                                   20


<210>  1955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1955
ucaacacagu ccugcuugau                                                   20


<210>  1956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1956
ccucaccucc accccugcuu                                                   20


<210>  1957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1957
uuacagaugu aggcagagag                                                   20


<210>  1958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1958
guaaggaucc ccucaccucc                                                   20


<210>  1959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1959
gccccucucu gccuacaucu                                                   20


<210>  1960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1960
cggacagcuc ccuuugaaag                                                   20


<210>  1961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1961
cacacacagc acccccaugu                                                   20


<210>  1962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1962
agucugaggu cuuuaaggua                                                   20


<210>  1963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1963
agcucucuug uucuugacgu                                                   20


<210>  1964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1964
aaggugggug cggagagaau                                                   20


<210>  1965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1965
uccugcccuc acuccauauu                                                   20


<210>  1966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1966
agcgcuccug gcgcucuucc                                                   20


<210>  1967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1967
uagccgacug cucggcagca                                                   20


<210>  1968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1968
cucacucgcu cuucagccuc                                                   20


<210>  1969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1969
agaacgcucc acccugccag                                                   20


<210>  1970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1970
ccgcccaccu uggcagagcu                                                   20


<210>  1971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1971
gcacuguucu ugucuccucu                                                   20


<210>  1972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1972
ccuacuucau uugcagagaa                                                   20


<210>  1973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1973
cugugcuggg cugcaguuac                                                   20


<210>  1974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1974
gggugacagc ugccucacau                                                   20


<210>  1975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1975
ucauaagcac uaugugaggc                                                   20


<210>  1976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1976
gaaagauaac acuuaaaaaa                                                   20


<210>  1977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1977
uucggauccu cauaagcacu                                                   20


<210>  1978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1978
guaacauuca uuuaaugggg                                                   20


<210>  1979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1979
uuacgucuuu ccaauagucu                                                   20


<210>  1980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1980
uuauaguaga aaaagaaaau                                                   20


<210>  1981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1981
cccugugccc uggcuucauc                                                   20


<210>  1982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1982
ggacuaccug caggcugauc                                                   20


<210>  1983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1983
gccugcaggu agucccgaug                                                   20


<210>  1984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1984
ggguggccag ccacaaacac                                                   20


<210>  1985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1985
cagcucagca uaugcacuaa                                                   20


<210>  1986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1986
cuagagggca gcgcugguaa                                                   20


<210>  1987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1987
uguuuucccu cagcugugga                                                   20


<210>  1988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1988
acagcaggua uaacggucag                                                   20


<210>  1989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1989
ggaagcagua augggucgga                                                   20


<210>  1990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1990
ucugcaggac acguuagcgu                                                   20


<210>  1991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1991
gaccuucagu gggaccggag                                                   20


<210>  1992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1992
cagucaccag aacccccuca                                                   20


<210>  1993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1993
gcacaaauuu guguaagugu                                                   20


<210>  1994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1994
guuuucuuuu cauagaaauc                                                   20


<210>  1995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1995
aauuguuucu ucugcuuguu                                                   20


<210>  1996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1996
ucaacucaua ccucucuucu                                                   20


<210>  1997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1997
uccauaagug auuuagacca                                                   20


<210>  1998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1998
cuuauggagg auuuucagug                                                   20


<210>  1999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  1999
acuggaaaaa ccuuucagcg                                                   20


<210>  2000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2000
gagaugaaag gucaaaaaug                                                   20


<210>  2001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2001
cagaugucag aacauuacug                                                   20


<210>  2002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2002
gaggugacaa auaagccccc                                                   20


<210>  2003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2003
aaugguagaa acugugaacc                                                   20


<210>  2004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2004
caaguagggu acaagucuac                                                   20


<210>  2005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2005
cauaaagcga uucaagaccu                                                   20


<210>  2006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2006
cuuuauguga uggaaggucu                                                   20


<210>  2007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2007
ucaucccuac cuuuuccccu                                                   20


<210>  2008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2008
ucccuaccuu uuccccuaug                                                   20


<210>  2009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2009
cuaccuuuuc cccuaugaag                                                   20


<210>  2010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2010
ugugugcauu aaauuugucc                                                   20


<210>  2011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2011
gaaaacacuu uaaggucagu                                                   20


<210>  2012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2012
cuagaacuga auauggagac                                                   20


<210>  2013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2013
ugucaggaaa aaucucuaga                                                   20


<210>  2014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2014
auaauagcac aucuugucag                                                   20


<210>  2015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2015
gguguccugc agcuaaggag                                                   20


<210>  2016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2016
ccucggucau cagguguccu                                                   20


<210>  2017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2017
caaauauaaa gacaacugaa                                                   20


<210>  2018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2018
ucugaaacug aaacucugga                                                   20


<210>  2019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2019
ccagaacucu uuucaucuuc                                                   20


<210>  2020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2020
aucuccagaa cucuuuucau                                                   20


<210>  2021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2021
ccaccaucca ucuccagaac                                                   20


<210>  2022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2022
gugugaaugu acuuaaaguc                                                   20


<210>  2023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2023
gccuguguuc aaguuuucac                                                   20


<210>  2024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2024
uggguaguuu aagugacaug                                                   20


<210>  2025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2025
uuguaacaac uucaugaggu                                                   20


<210>  2026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2026
uauuucaucu uuguaacaac                                                   20


<210>  2027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2027
ugucaccugu agcuccugag                                                   20


<210>  2028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2028
gcccugauuc cugccuuucu                                                   20


<210>  2029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2029
gggcagauau ggaggcuuua                                                   20


<210>  2030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2030
ggccuuaugu cagaaaggca                                                   20


<210>  2031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2031
cagaaaagcu cacccaucag                                                   20


<210>  2032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2032
uuauagaauc ccagaaaagc                                                   20


<210>  2033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2033
gucacucuuu uaauacuucc                                                   20


<210>  2034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2034
caaaaaaaua ugaggggaag                                                   20


<210>  2035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2035
ugcaaauagg uuucuguacc                                                   20


<210>  2036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2036
gacucaguca gggccugcuu                                                   20


<210>  2037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2037
aaaccgggca cauguucccc                                                   20


<210>  2038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2038
uguggacagu agucgcugcu                                                   20


<210>  2039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2039
aagcugaggg aagagaaaag                                                   20


<210>  2040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2040
acaaacuauu uuaauaaaca                                                   20


<210>  2041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2041
guuuauuaaa auaguuuguc                                                   20


<210>  2042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2042
cuaaauucua auggguggaa                                                   20


<210>  2043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2043
ggcaguaaaa aguuuuguuc                                                   20


<210>  2044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2044
uauuacugag aguaguucua                                                   20


<210>  2045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2045
aaaaguacua gaacuacucu                                                   20


<210>  2046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2046
aucuaaaagu acuagaacua                                                   20


<210>  2047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2047
uaaaauuuca uuuaucaauc                                                   20


<210>  2048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2048
ccugcucuau guuuuaggga                                                   20


<210>  2049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2049
cuaaaacaua gagcagguga                                                   20


<210>  2050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2050
cugcacuuug ggaggcaaag                                                   20


<210>  2051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2051
acccgccuuu gccucccaaa                                                   20


<210>  2052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2052
cuugagguca ggaguuugag                                                   20


<210>  2053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2053
uguugcucag gcuggucuca                                                   20


<210>  2054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2054
caccuacuug ggaggcugag                                                   20


<210>  2055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2055
ucccaccuca gccucccaag                                                   20


<210>  2056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2056
cuugagcuug uggggcagag                                                   20


<210>  2057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2057
cagcucacug caaacucugc                                                   20


<210>  2058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2058
ugccacugca cucuagacug                                                   20


<210>  2059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2059
uuuuucuaca acagaaaaag                                                   20


<210>  2060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2060
cuuaauacau agcaaaaucu                                                   20


<210>  2061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2061
aaaaugauuc agauuaagug                                                   20


<210>  2062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2062
uuuuagauuu ugcuauguau                                                   20


<210>  2063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2063
gaaucauuuu agauuuugcu                                                   20


<210>  2064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2064
ugcgucucag guuuugguuu                                                   20


<210>  2065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2065
gggaguggcc guuagcuugu                                                   20


<210>  2066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2066
ugccuuaucu gguaaaagaa                                                   20


<210>  2067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2067
gguaaaagaa ucccaagcua                                                   20


<210>  2068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2068
caagcuacac cuuccugacu                                                   20


<210>  2069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2069
ucucacccua cacauuucuc                                                   20


<210>  2070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2070
cuggguuuua auuuuucuga                                                   20


<210>  2071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2071
gucacuguag aucccaccga                                                   20


<210>  2072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2072
acagugacug auacaguaga                                                   20


<210>  2073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2073
caccgagagu agcaggaggc                                                   20


<210>  2074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2074
auuguucugg ccaguucugc                                                   20


<210>  2075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2075
acauauuuac uauagacauu                                                   20


<210>  2076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2076
auuuucuguc ucaaacacaa                                                   20


<210>  2077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2077
uauacaagua gagcgaguca                                                   20


<210>  2078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2078
ucaauaaccu gggaaaggaa                                                   20


<210>  2079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2079
cuuggguaga auuauaaaga                                                   20


<210>  2080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2080
cagcacuuug caaggccaag                                                   20


<210>  2081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2081
uccugccuug gccuugcaaa                                                   20


<210>  2082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2082
cuugaggcca ggaguucuga                                                   20


<210>  2083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2083
ugcuuuguug cccaggcuag                                                   20


<210>  2084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2084
caucucuaaa aaauaaaaaa                                                   20


<210>  2085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2085
cuaaaaaaua aaaaaagaaa                                                   20


<210>  2086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2086
uuuugccuca gccuccugua                                                   20


<210>  2087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2087
uuugugccua ggacuuugag                                                   20


<210>  2088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2088
caaauauauc uuaaaacuaa                                                   20


<210>  2089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2089
uaaaacuaag agaaaaaacu                                                   20


<210>  2090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2090
auguguugcu aucaacuaga                                                   20


<210>  2091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2091
acuagaucua uaguucucug                                                   20


<210>  2092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2092
aguugauagc aacacauaga                                                   20


<210>  2093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2093
auaguucucu guggguuaug                                                   20


<210>  2094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2094
uaaaguauau guccucauaa                                                   20


<210>  2095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2095
uaaggauaag agguuuaugc                                                   20


<210>  2096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2096
uuaggaucau aaaguauaug                                                   20


<210>  2097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2097
uagcuguauu ucuaguucuu                                                   20


<210>  2098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2098
acaacaaacc cauauaguuu                                                   20


<210>  2099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2099
aucaacaaca aacccauaua                                                   20


<210>  2100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2100
cuaaggagca auaaucugcc                                                   20


<210>  2101
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2101
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2102
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2102
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgacgcgucc ucgagcagaa gcaucaaag                              99


<210>  2103
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2103
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgcuccguuc gagcagaagc aucaaag                                97


<210>  2104
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2104
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcccu cuucggaggg aagcaucaaa g                                      91


<210>  2105
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2105
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcagga guuucuaugg aaacccugaa gcaucaaag                              99


<210>  2106
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2106
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2107
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2107
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcg cuugcgcaga agcaucaaag                                        90


<210>  2108
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2108
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2109
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2109
uacuggcgcu uuuaucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2110
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2110
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga cuucgguccg auaaauaaga agcaucaaag                 110


<210>  2111
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2111
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcacau gaggauuacc caugugaagc aucaaag                                97


<210>  2112
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2112
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucgugaga aauccgauaa auaagaagca ucaaag                     106


<210>  2113
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2113
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugca ugucuaagac agcagaagca ucaaag                                 96


<210>  2114
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2114
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccga agcaucaaag                                        90


<210>  2115
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2115
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaauc cauugcacuc cggauugaag caucaaag                               98


<210>  2116
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2116
uacuggcgcu uuucucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2117
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2117
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2118
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2118
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cguuugcggc uacgagcaga agcaucaaag                            100


<210>  2119
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2119
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagag auaaauaaga agcaucaaag                            100


<210>  2120
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2120
uacggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2121
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2121
uacuggcgcc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2122
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2122
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaucggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2123
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2123
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2124
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2124
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagaa auccgauaaa uaagaagcau caaag                      105


<210>  2125
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2125
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggagagaaau ccgauaaaua agaagcauca aag                        103


<210>  2126
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2126
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gagauaaaua agaagcauca aag                        103


<210>  2127
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2127
uacuggcgcu uuuaucucau uacuuuggag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag aguauccgau aaauaagaag caucaaag                   108


<210>  2128
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2128
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2129
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2129
agcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cggagagaaa ugccgauaaa uaagaagcau caaag                      105


<210>  2130
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2130
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaauaagaa gcaucaaag                  109


<210>  2131
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2131
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uguaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2132
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2132
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggacuucggu ccgauaaaua agcgcaucaa ag                         102


<210>  2133
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2133
uacuggcgcu uuucucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2134
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2134
guggcgcuuu uaucucauua cuuugagagc caucaccagc gacuaugucg uauggguaaa       60

gcgcuuauuu aucggagaga aauccgauaa auaagaagca ucaaag                     106


<210>  2135
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2135
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaccuuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag                 110


<210>  2136
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2136
gauggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2137
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2137
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaagaagca ucaaag                     106


<210>  2138
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2138
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaucuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2139
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2139
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aaggcuuauu uaucggagag aaauccgaua aaaagaagca ucaaag                     106


<210>  2140
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2140
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaaagaagc aucaaag                    107


<210>  2141
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2141
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2142
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2142
cggcgcuuuu cucgcauuac uuugagagcc aucaccagcg acuaugucgu auggguaaag       60

cgcuuauugu aucgagagau aaauaagaag caucaaag                               98


<210>  2143
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2143
cacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2144
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2144
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau guaucggcuu cggccgauac auaagaagca ucaaag                     106


<210>  2145
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2145
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uguaucggcu ucggccgaua cauaagaagc aucaaag                    107


<210>  2146
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2146
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggug       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2147
<211>  64
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2147
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaag                                                                    64


<210>  2148
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2148
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

ag                                                                      62


<210>  2149
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2149
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

agcgcuuauu uaucggcuuc ggccgauaaa uaagaagcau caaag                      105


<210>  2150
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2150
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuaca cugggaucgc ugaauuagag aucggcgucc uuucauucua uauacuuugg      120

aguuuuaaaa ugucucuaag uacagaagca ucaaag                                156


<210>  2151
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2151
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuucggucgu auggguaaag       60

cgcuuauuua ucggcuucgg ccgauaaaua agaagcauca aag                        103


<210>  2152
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2152
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau uuaucggcuu cggccgauaa auaagaagca ucaaag                     106


<210>  2153
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2153
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2154
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2154
uacuggcgcu uuuaucucau uacuuugaga gccaugcucc accagcgacu augucguaug       60

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              112


<210>  2155
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2155
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgggguu aggguuaggg uuagggaagc aucaaag                                97


<210>  2156
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2156
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcggaggg agggagggag agggaaagca ucaaag                                 96


<210>  2157
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2157
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcguuggg uuaggguuag gguuagggaa aagcaucaaa g                          101


<210>  2158
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2158
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccgg aagcaucaaa g                                      91


<210>  2159
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2159
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccugc ucaguacgag aggaaccgca ggaagcauca aag                        103


<210>  2160
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2160
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2161
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2161
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2162
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2162
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2163
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2163
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2164
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2164
uacuggcgcc uuuaucugca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2165
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2165
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2166
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2166
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2167
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2167
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2168
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2168
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2169
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2169
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2170
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2170
uacuggcgcc uuuaucauca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2171
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2171
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg ccggcauggu      120

cccagccucc ucgcuggcgc cggcugggca acauuccgag gggaccgucc ccucgguaau      180

ggcgaauggg accc                                                        194


<210>  2172
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2172
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2173
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2173
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga aauccgauaa auaagaagca ucaaag                     106


<210>  2174
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2174
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2175
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2175
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccgga cuucgguccg gaagcaucaa ag                                     92


<210>  2176
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2176
uacuggcgcu uuuaucggau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2177
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2177
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2178
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2178
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2179
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2179
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2180
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2180
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gucggcaugg      120

caucuccacc uccucgcggu ccgaccuggg cauccgaagg aggacgcacg uccacucgga      180

uggcuaaggg agagcca                                                     197


<210>  2181
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2181
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggcg caucaaag                                          88


<210>  2182
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2182
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaguu uuggccggca      120

uggucccagc cuccucgcug gcgccggcug ggcaacaugc uucggcaugg cgaaugggac      180

cccggg                                                                 186


<210>  2183
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2183
gauggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2184
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2184
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2185
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2185
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucuuacg gacuucgguc cguaagagca ucaaag                                 96


<210>  2186
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2186
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucggacg accucucggu cguccgagca ucaaag                                 96


<210>  2187
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2187
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc ugucaccgga      120

ugugcuuucc ggucugauga guccgugagg acgaaacagg                            160


<210>  2188
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2188
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2189
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2189
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2190
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2190
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucaggug ggacgaccuc ucggucgucc uaucugagca ucaaag                     106


<210>  2191
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2191
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagga uggccggcau      120

ggucccagcc uccucgcugg cgccggcugg gcaacaccuu cggguggcga augggac         177


<210>  2192
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2192
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2193
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2193
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguacugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2194
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2194
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgugag aaauccgaua aauaagaagc aucaaag                    107


<210>  2195
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2195
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2196
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2196
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2197
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2197
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2198
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2198
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2199
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2199
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2200
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2200
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2201
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2201
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2202
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2202
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2203
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2203
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2204
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2204
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2205
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2205
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2206
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2206
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2207
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2207
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2208
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2208
gauggccggc auggucccag ccuccucgcu ggcgccggcu gggcaacacc uucggguggc       60

gaaugggacu acuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc      120

guauggguaa agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag         177


<210>  2209
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2209
ggccggcaug gucccagccu ccucgcuggc gccggcuggg caacauuccg aggggaccgu       60

ccccucggua auggcgaaug ggacccuacu ggcgcuuuua ucucauuacu uugagagcca      120

ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau      180

aagaagcauc aaag                                                        194


<210>  2210
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2210
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagcgca ucaaag                                 96


<210>  2211
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2211
cgugguuagg gccacguuaa auaguugcuu aagcccuaag cguugaucuu cggaucaggu       60

gcaauacugg cgcuuuuauc ucauuacuuu gagagccauc accagcgacu augucguaug      120

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              172


<210>  2212
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2212
gggucggcau ggcaucucca ccuccucgcg guccgaccug ggcauccgaa ggaggacgca       60

cguccacucg gauggcuaag ggagagccau acuggcgcuu uuaucucauu acuuugagag      120

ccaucaccag cgacuauguc guauggguaa agcgcuuauu uaucggagag aaauccgaua      180

aauaagaagc aucaaag                                                     197


<210>  2213
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2213
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc aguacugaug      120

aguccgugag gacgaaacga guaagcucgu cuacuggcgc uuuuaucuca u               171


<210>  2214
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2214
uacuggcgcc uuuaucucau uacuuuagag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2215
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2215
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgu acuggcgcuu       60

uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa agcgcuuauu      120

uaucggagag aaauccgaua aauaagaagc aucaaag                               157


<210>  2216
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2216
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugcgca ucaaag                     106


<210>  2217
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2217
uacuggcgcc uuuaucucau uacuuuagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2218
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2218
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagca uuccucagaa      120

aaugacaaac cuguggggcg uaaguagauc uucggaucua ugaucgugca gacguuaaaa      180

ucaggu                                                                 186


<210>  2219
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2219
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucgcgu guagcgaagc a               171


<210>  2220
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2220
cauuccucag aaaaugacaa accugugggg cguaaguaga ucuucggauc uaugaucgug       60

cagacguuaa aaucagguua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2221
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2221
uuuuggccgg caugguccca gccuccucgc uggcgccggc ugggcaacau gcuucggcau       60

ggcgaauggg accccgggua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2222
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2222
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgc guguagcgaa       60

gcauacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2223
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2223
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gagccccgcu      120

gaugaggucg gggagaccga aagggacuuc ggucccuacg gggcuccc                   168


<210>  2224
<211>  144
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2224
ccacccccac caccaccccc acccccacca ccacccuacu ggcgcuuuua ucucauuacu       60

uugagagcca ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa      120

uccgauaaau aagaagcauc aaag                                             144


<210>  2225
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2225
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucg                               157


<210>  2226
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2226
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg ugguuagggc      120

cacguuaaau aguugcuuaa gcccuaagcg uugaucuucg gaucaggugc aa              172


<210>  2227
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2227
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg caauaaagcg      120

guuacaagcc cgcaaaaaua gcagaguaau gucgcgauag cgcggcauua augcagcuuu      180

auug                                                                   184


<210>  2228
<211>  122
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2228
uacuggcgcu uuuaucucau uacuauuauc ucauuacuuu gagagccauc accagcgacu       60

augucguaug gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa      120

ag                                                                     122


<210>  2229
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2229
ggcaauaaag cgguuacaag cccgcaaaaa uagcagagua augucgcgau agcgcggcau       60

uaaugcagcu uuauuguacu ggcgcuuuua ucucauuacu uugagagcca ucaccagcga      120

cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau aagaagcauc      180

aaag                                                                   184


<210>  2230
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2230
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagac ccgcaaggcc      120

gacggcaucc gccgccgcug gugcaagucc agccgccccu ucgggggcgg gcgcucaugg      180

guaac                                                                  185


<210>  2231
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2231
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aag                                                                     63


<210>  2232
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2232
gggagccccg cugaugaggu cggggagacc gaaagggacu ucggucccua cggggcuccc       60

uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua      120

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   168


<210>  2233
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2233
ccaguacuga ugaguccgug aggacgaaac gaguaagcuc gucuacuggc gcuuuuaucu       60

cauuacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2234
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2234
acccgcaagg ccgacggcau ccgccgccgc uggugcaagu ccagccgccc cuucgggggc       60

gggcgcucau ggguaacuac uggcgcuuuu aucucauuac uuugagagcc aucaccagcg      120

acuaugucgu auggguaaag cgcuuauuua ucggagagaa auccgauaaa uaagaagcau      180

caaag                                                                  185


<210>  2235
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2235
ccugucaccg gaugugcuuu ccggucugau gaguccguga ggacgaaaca gguacuggcg       60

cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg uaaagcgcuu      120

auuuaucgga gagaaauccg auaaauaaga agcaucaaag                            160


<210>  2236
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2236
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag                            100


<210>  2237
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2237
guacuggcgc uuuuaucuga uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcuccc ucuucggagg gagcaucaaa g                                      91


<210>  2238
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2238
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2239
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2239
acuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2240
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2240
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2241
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2241
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2242
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2242
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2243
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2243
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2244
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2244
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2245
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2245
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2246
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2246
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2247
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2247
acuggcgccu uuaucaucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2248
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2248
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2249
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2249
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaag                                 96


<210>  2250
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2250
acuggcacuu uuaccugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2251
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2251
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2252
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2252
acuggcccuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2253
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2253
acuggcgcuu uuaccugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2254
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2254
acuggcgcuu uuaucugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2255
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2255
acuggcaccu uuaccugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2256
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2256
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2257
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2257
acuggccccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2258
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2258
acuggcgccu uuaucugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2259
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2259
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2260
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2260
gacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2261
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2261
acuggcgccu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2262
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2262
acuggcgcau uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2263
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2263
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2264
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2264
acuggcgcuu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2265
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2265
acuggcgcau uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2266
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2266
acuggcgcuu uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2267
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2267
acuggcgcuu uuauucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2268
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2268
acggcgcuuu uaucugauua cuuugagagc caucaccagc gacuaugucg uaguggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2269
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2269
acuggcgcuu uuauaugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2270
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2270
acuggcgcuu uuaucuugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2271
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2271
acuggcgcuu uuaucugauu acuuugagag ccagcaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2272
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2272
acuggcgcug uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2273
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2273
acuggcgcuc uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2274
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2274
acuggcgcuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2275
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2275
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2276
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2276
acuggcgcuu ugaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2277
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2277
acuggcgcuu ucaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2278
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2278
acuggcgcug uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2279
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2279
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2280
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2280
acuggcgcuu uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2281
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2281
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  2282
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2282
acuggcacuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2283
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2283
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucaaag                               98


<210>  2284
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2284
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guauggguaa       60

agccgcuuac ggacuucggu ccguaagagg caucagag                               98


<210>  2285
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  gNA Variant Scaffold

<400>  2285
acuggcacuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2286
gccaaagucu guaaaagcac                                                   20


<210>  2287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2287
augaugucuu uucuuacuca                                                   20


<210>  2288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2288
uagaugccau uuguuaaaag                                                   20


<210>  2289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2289
uuuaauaaag aguuuugagu                                                   20


<210>  2290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2290
agaauucgaa gggaacccag                                                   20


<210>  2291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2291
uuggaauuug gugacugguu                                                   20


<210>  2292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2292
agagguauug uggaaagaga                                                   20


<210>  2293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2293
gucugucccu ugccccacca                                                   20


<210>  2294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2294
ugcauccuuc uuuacuccau                                                   20


<210>  2295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2295
uucuuuacuc cauccuucaa                                                   20


<210>  2296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2296
uucaauacaa cugccagagg                                                   20


<210>  2297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2297
ucuggcaguu guauugaagg                                                   20


<210>  2298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2298
uacaauugau uacauuucag                                                   20


<210>  2299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2299
auuguaggau ucuuuccacu                                                   20


<210>  2300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2300
uagacacuau ugacuguaug                                                   20


<210>  2301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2301
aaucuuagac acuauugacu                                                   20


<210>  2302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2302
uuugcgcuaa cacgaugccu                                                   20


<210>  2303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2303
uguuagcgca aaugauauua                                                   20


<210>  2304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2304
cuaucacucc ccuucagucc                                                   20


<210>  2305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2305
cuccccuuca guccccugca                                                   20


<210>  2306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2306
ucgugucagu caugugucua                                                   20


<210>  2307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2307
agcauuguua auugccauuc                                                   20


<210>  2308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2308
acguucuagc ucuaucaccu                                                   20


<210>  2309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2309
ccuucuggcc gacccuggac                                                   20


<210>  2310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2310
gaguguugca gcuggaagaa                                                   20


<210>  2311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2311
ccccuacucu uucuuuucuu                                                   20


<210>  2312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2312
guuuagugac uugaaaucuc                                                   20


<210>  2313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2313
gauuuuauau auguccauau                                                   20


<210>  2314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2314
gaucuguuua gugacuugaa                                                   20


<210>  2315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2315
uaguuuguuu uccagaagau                                                   20


<210>  2316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2316
ucuggaaaac aaacuaggau                                                   20


<210>  2317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2317
uuaacucaga guauucccau                                                   20


<210>  2318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2318
uggcacauuu uucuauuuua                                                   20


<210>  2319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2319
ucacaaccug ugaagucagu                                                   20


<210>  2320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2320
ccucugauau aggucuguag                                                   20


<210>  2321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2321
gaggagauua aguuccucuc                                                   20


<210>  2322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2322
acuaaucacc ugcuucuugu                                                   20


<210>  2323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2323
ccugcuucuu guuaacacua                                                   20


<210>  2324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2324
ccacuauaaa uacuggugca                                                   20


<210>  2325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2325
auguaacagu guuggucccu                                                   20


<210>  2326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2326
uugcucacgc uaccccaggg                                                   20


<210>  2327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2327
ccagucaucc uugcucacgc                                                   20


<210>  2328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2328
auguaauuaa aaauuaaaga                                                   20


<210>  2329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2329
uuaauuuuua auuacaugga                                                   20


<210>  2330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2330
uucuaguaua ggcucaguuu                                                   20


<210>  2331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2331
uuuugcucca aggcaguaug                                                   20


<210>  2332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2332
ggcuaucacu cguuuaacug                                                   20


<210>  2333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2333
cucguuuaac ugaggucuua                                                   20


<210>  2334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2334
caaugagugc caagagcgag                                                   20


<210>  2335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2335
guuguugcug ccuuuaacug                                                   20


<210>  2336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2336
acccagauuu uaagauaauu                                                   20


<210>  2337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2337
ggguagauuu caguuaaagg                                                   20


<210>  2338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2338
uaaaaucugg guagauuuca                                                   20


<210>  2339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2339
auagacuucu aacaguuaag                                                   20


<210>  2340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2340
guuuuucaaa ggcaaaagcu                                                   20


<210>  2341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2341
ccaacagauc caaaaaauau                                                   20


<210>  2342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2342
guuggugauu auuuuaauug                                                   20


<210>  2343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2343
aaaaaauauu aagcaaaaaa                                                   20


<210>  2344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2344
uuuuuuuuuu uuuuugcuua                                                   20


<210>  2345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2345
augaacaaua uaauucuggu                                                   20


<210>  2346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2346
guaaaucagg uagggaagaa                                                   20


<210>  2347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2347
gguagggaag aaggacugga                                                   20


<210>  2348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2348
uccaguccuu cuucccuacc                                                   20


<210>  2349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2349
aaccuucccc uuccagcaga                                                   20


<210>  2350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2350
ucaauccaac cuuccccuuc                                                   20


<210>  2351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2351
uggugccugu guggcucauc                                                   20


<210>  2352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2352
cuuuugugug uuccuggucc                                                   20


<210>  2353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2353
ccaaucucuu uuguguguuc                                                   20


<210>  2354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2354
uuucguuaau uguagagggu                                                   20


<210>  2355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2355
aaaucauuuc guuaauugua                                                   20


<210>  2356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2356
aucaaaauca uuucguuaau                                                   20


<210>  2357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2357
gggccccaga gggagguaaa                                                   20


<210>  2358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2358
auaagaaaau gugccuccuu                                                   20


<210>  2359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2359
gcugugugag uacucagugu                                                   20


<210>  2360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2360
cucacagucu aggggggaua                                                   20


<210>  2361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2361
ccccuagacu gugagggauc                                                   20


<210>  2362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2362
cuagguaucc ccccuagacu                                                   20


<210>  2363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2363
uucaaagagg uaaaaauaua                                                   20


<210>  2364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2364
ucaguggcag cuuucggcag                                                   20


<210>  2365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2365
acccauauag aaggaguuau                                                   20


<210>  2366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2366
aaaaagacaa agcuaccuaa                                                   20


<210>  2367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2367
gaaggaugcu cuguguuuuu                                                   20


<210>  2368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2368
uucugauaga gaaaugcuua                                                   20


<210>  2369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2369
aauggcagga aacuaaauaa                                                   20


<210>  2370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2370
uccuaguagc uucugggucu                                                   20


<210>  2371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2371
auagacagga ugaauacucc                                                   20


<210>  2372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2372
ugucuaugga ugcaaaaacu                                                   20


<210>  2373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2373
ccguaacaaa ccuaugagga                                                   20


<210>  2374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2374
aacacaguaa guuuaaagca                                                   20


<210>  2375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2375
ugacaagacc caggaagagu                                                   20


<210>  2376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2376
aguguccuaa cuuaugugug                                                   20


<210>  2377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2377
uauaggacaa uuugugguuu                                                   20


<210>  2378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2378
aauacagcaa aaccacaaau                                                   20


<210>  2379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2379
uccaauacag caaaaccaca                                                   20


<210>  2380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2380
uacauucaaa uauauuucaa                                                   20


<210>  2381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2381
uugaaauaua uuugaaugua                                                   20


<210>  2382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2382
gcauccccuu uguuuuuaca                                                   20


<210>  2383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2383
ccuuuguuuu uacaaaguac                                                   20


<210>  2384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2384
cauuaucuca uuauaccugg                                                   20


<210>  2385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2385
cauuauaccu ggggaauuau                                                   20


<210>  2386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2386
ucagugcaaa augaaaauac                                                   20


<210>  2387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2387
gaacggucag guucacgaaa                                                   20


<210>  2388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2388
ccuuaauuug aaccacuacu                                                   20


<210>  2389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2389
uaaagaguug uuuuaaaaaa                                                   20


<210>  2390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2390
uucauuuggg agaggugaga                                                   20


<210>  2391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2391
cuucauucua agauauguua                                                   20


<210>  2392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2392
uagaaugaag agauacugaa                                                   20


<210>  2393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2393
caaaggaaug uugguaagcu                                                   20


<210>  2394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2394
gaaugcaaaa caaguaacgc                                                   20


<210>  2395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2395
ucacaauaca guggcguuac                                                   20


<210>  2396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2396
acguaucugu caucagggaa                                                   20


<210>  2397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2397
gucaucaggg aagauaaagu                                                   20


<210>  2398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2398
gggaagauaa aguggcuguu                                                   20


<210>  2399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2399
ucccugauga cagauacguc                                                   20


<210>  2400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2400
cagguuuuaa gccagcucaa                                                   20


<210>  2401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2401
auaaagggac ugguuuuaga                                                   20


<210>  2402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2402
ccagccucag aguuuuuccc                                                   20


<210>  2403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2403
gcaggucugg cccugccucu                                                   20


<210>  2404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2404
ugaguucuuc auguacuggc                                                   20


<210>  2405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2405
caaaguaggc agaauaggga                                                   20


<210>  2406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2406
aaggccccau ugucacuagc                                                   20


<210>  2407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2407
cuuuuccacu ucaaacucuu                                                   20


<210>  2408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2408
acacacagag cacgugaugc                                                   20


<210>  2409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2409
cgugcucugu guguggauac                                                   20


<210>  2410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2410
gucucccuua gcaggaaagg                                                   20


<210>  2411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2411
cugcuccacc aaugcauuag                                                   20


<210>  2412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2412
cugagcuuua cuccuugccu                                                   20


<210>  2413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2413
ccauucucag gcaaggagua                                                   20


<210>  2414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2414
aaauuaagca gcuucauccc                                                   20


<210>  2415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2415
aaaguauacc acaauaaagu                                                   20


<210>  2416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2416
aguacauaau aaguacucca                                                   20


<210>  2417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2417
aucaaauaaa agaaauacga                                                   20


<210>  2418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2418
aauaaaagaa auacgaugga                                                   20


<210>  2419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2419
uauuucuuuu auuugauaga                                                   20


<210>  2420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2420
aucguauuuc uuuuauuuga                                                   20


<210>  2421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2421
gcccaccucg gcuuaccgag                                                   20


<210>  2422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2422
cuugagccca ggaguuugag                                                   20


<210>  2423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2423
uguuucuaua caaaauacaa                                                   20


<210>  2424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2424
ucccuccuca gcccccuggu                                                   20


<210>  2425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2425
cugaaaccca gaaggucuag                                                   20


<210>  2426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2426
ggggucacug cagccuagac                                                   20


<210>  2427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2427
gggugacagc aaaccuggug                                                   20


<210>  2428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2428
gcacuaucau ucaguuuaua                                                   20


<210>  2429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2429
uucaguuuau aacagcacaa                                                   20


<210>  2430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2430
aaaugcaaag uugugcuguu                                                   20


<210>  2431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2431
gacuuaaaag aaccaccacc                                                   20


<210>  2432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2432
accuuucccu cuuaugacuu                                                   20


<210>  2433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2433
uuacaacuuc uucauacaau                                                   20


<210>  2434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2434
ccuacaaaaa gaaacacagc                                                   20


<210>  2435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2435
cuaguggaau agcuaugguu                                                   20


<210>  2436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2436
gguaaggacu acuuuuauau                                                   20


<210>  2437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2437
gcuuccuccu aggggccagu                                                   20


<210>  2438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2438
ugugccgcag agcugaaugc                                                   20


<210>  2439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2439
ucuucugagg cauucagcuc                                                   20


<210>  2440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2440
ccagcccuaa uuccuugcug                                                   20


<210>  2441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2441
ugugacagca aggaauuagg                                                   20


<210>  2442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2442
agacaaaaau ugguuuuaaa                                                   20


<210>  2443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2443
aauuaaaaaa acuccugagc                                                   20


<210>  2444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2444
augaguaacu auacccaccu                                                   20


<210>  2445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2445
gaauucuuac aaguaauaua                                                   20


<210>  2446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2446
ugugaauuau auuacuugua                                                   20


<210>  2447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2447
uaaaaaacau accauauaga                                                   20


<210>  2448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2448
agucuaaaaa uuuuuuagag                                                   20


<210>  2449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2449
ucuguauuag gaaaagauau                                                   20


<210>  2450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2450
uuuccuaaua cagaagauuu                                                   20


<210>  2451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2451
guuacuggag guacuacuug                                                   20


<210>  2452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2452
uuccucuaac caguuaaaaa                                                   20


<210>  2453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2453
uguuauaaau gucugucuua                                                   20


<210>  2454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2454
gacuuuccuu uuguucuuau                                                   20


<210>  2455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2455
agucucagau ucagauggac                                                   20


<210>  2456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2456
gagacuggau uguaucagac                                                   20


<210>  2457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2457
gaaucugaga cuggauugua                                                   20


<210>  2458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2458
auuuuaccuu ccagagaaag                                                   20


<210>  2459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2459
uucucuggaa gguaaaaugg                                                   20


<210>  2460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2460
aggaacugaa acuaagcuuu                                                   20


<210>  2461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2461
auucuaccgc ugagucacau                                                   20


<210>  2462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2462
cucugucucu uaaaaaaagg                                                   20


<210>  2463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2463
cucccuccac uacguuacuu                                                   20


<210>  2464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2464
cagaugcaaa gaauaaaaaa                                                   20


<210>  2465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2465
gugauuaugu gaagaaguaa                                                   20


<210>  2466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2466
gcuugguuuc cagccccuau                                                   20


<210>  2467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2467
auuugcucca ucggcuuggu                                                   20


<210>  2468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2468
ccguugucau ucugucaggc                                                   20


<210>  2469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2469
acucagccgu gaacuuacuu                                                   20


<210>  2470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2470
gugaucuaga uuuaagacca                                                   20


<210>  2471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2471
cagaugaauu ucuagggacu                                                   20


<210>  2472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2472
agauuuaaga ccaggcuuac                                                   20


<210>  2473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2473
agaucacaga ugaauuucua                                                   20


<210>  2474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2474
ucagaggaaa cgaacuaaug                                                   20


<210>  2475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2475
auccugucac acccauuaua                                                   20


<210>  2476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2476
ugucacaccc auuauaaaua                                                   20


<210>  2477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2477
uguaaaguac uuugaaaaug                                                   20


<210>  2478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2478
aucagcuggg caucagacag                                                   20


<210>  2479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2479
gcugggcauc agacagaauu                                                   20


<210>  2480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2480
gacagaauuc acugagcaaa                                                   20


<210>  2481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2481
cuagggaggc ugcacuaacu                                                   20


<210>  2482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2482
uuuguuuggg uugguacaug                                                   20


<210>  2483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2483
gcauuugaag caguaauucc                                                   20


<210>  2484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2484
guauuuaguu cauugaggca                                                   20


<210>  2485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2485
ugggaaguaa cugcuguacc                                                   20


<210>  2486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2486
aggggcguua aguccuuaca                                                   20


<210>  2487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2487
caacgcagac caaagcaggc                                                   20


<210>  2488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2488
caaacaccag gguaggccag                                                   20


<210>  2489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2489
ugauaaaaca aggcacuguc                                                   20


<210>  2490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2490
ggauaagguc ggucucauuu                                                   20


<210>  2491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2491
ugaaagaaag agaaaggugg                                                   20


<210>  2492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2492
ugcuuuuuca caccaccuuu                                                   20


<210>  2493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2493
gaagguaaag uucaucucua                                                   20


<210>  2494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2494
uuucacaaua aauuuucagc                                                   20


<210>  2495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2495
aaagaauuca gacuacuaac                                                   20


<210>  2496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2496
aucuguaagc aauauuuacu                                                   20


<210>  2497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2497
guaagcaaua uuuacuauga                                                   20


<210>  2498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2498
uaaaaauuau aaagaaauaa                                                   20


<210>  2499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2499
uagcaauuga uagugaugag                                                   20


<210>  2500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2500
auugcuauga uuucguguuu                                                   20


<210>  2501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2501
cuaucaauug cuaugauuuc                                                   20


<210>  2502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2502
cucaucacua ucaauugcua                                                   20


<210>  2503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2503
ggaagaaugu agaaguaauu                                                   20


<210>  2504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2504
cagugaauua cuucuacauu                                                   20


<210>  2505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2505
cauuaccucu cugguuaaaa                                                   20


<210>  2506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2506
aauuuguuug aaaaagaaca                                                   20


<210>  2507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2507
auuucauuca gcaacagacc                                                   20


<210>  2508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2508
gcacuuuucc cucuaaucua                                                   20


<210>  2509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2509
aguaggcaaa uaaauguuug                                                   20


<210>  2510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2510
caggcaagua uucagugacc                                                   20


<210>  2511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2511
ucucaggcaa guauucagug                                                   20


<210>  2512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2512
cuggaagaga cacaaauuuc                                                   20


<210>  2513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2513
auucucgucc uucagaacua                                                   20


<210>  2514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2514
aaacuuuuug aaagcaaugc                                                   20


<210>  2515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2515
auucuucagu aucaacccuu                                                   20


<210>  2516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2516
acccuuuaaa aaaaagcaga                                                   20


<210>  2517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2517
gcuuuuuuuu aaaggguuga                                                   20


<210>  2518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2518
uaugccagga uaggcauagu                                                   20


<210>  2519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2519
uggcauagga uuggucacuu                                                   20


<210>  2520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2520
uaugccagac auuaaaagaa                                                   20


<210>  2521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2521
cuuucuuuua augucuggca                                                   20


<210>  2522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2522
gaaaaagaaa aaauaaugua                                                   20


<210>  2523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2523
ucagcaccug guaaggugcc                                                   20


<210>  2524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2524
guuuuuaucu ucagcaccug                                                   20


<210>  2525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2525
uugguuuuau gguuuuuuug                                                   20


<210>  2526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2526
uauucaucau ugguuuuaug                                                   20


<210>  2527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2527
ccuuaucugg auaugauuuu                                                   20


<210>  2528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2528
ggauaugauu uugcccaauu                                                   20


<210>  2529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2529
agauaaggag auuagaguag                                                   20


<210>  2530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2530
uauccagaua aggagauuag                                                   20


<210>  2531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2531
ucgaauuggg caaaaucaua                                                   20


<210>  2532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2532
guugugacag agggcacugg                                                   20


<210>  2533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2533
aaacauauca cuucucaccu                                                   20


<210>  2534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2534
cuucucaccu gaguuucuuc                                                   20


<210>  2535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2535
acggacaaag aagaaacuca                                                   20


<210>  2536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2536
uugcauggca aaggugagcu                                                   20


<210>  2537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2537
auauuauccu ugcauggcaa                                                   20


<210>  2538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2538
ucuuucaugu uucccucucu                                                   20


<210>  2539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2539
auaaaacuuc ugugaaaaau                                                   20


<210>  2540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2540
uaauuuaguu cguaacugug                                                   20


<210>  2541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2541
uauucauaua uugugugugu                                                   20


<210>  2542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2542
uguguguaua ucauauucau                                                   20


<210>  2543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2543
ucucaaaaca guuguuagac                                                   20


<210>  2544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2544
ugcggucuaa caacuguuuu                                                   20


<210>  2545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2545
uuagucuugu gauauuuuau                                                   20


<210>  2546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2546
caagacuaaa gauuaacuuu                                                   20


<210>  2547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2547
ccacaaagac caauauccau                                                   20


<210>  2548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2548
auugacauga gcucacaguu                                                   20


<210>  2549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2549
aguuaguuac uuacagcauu                                                   20


<210>  2550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2550
cuacuguaua caucucuauu                                                   20


<210>  2551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2551
cuauucuuca uaaacuugag                                                   20


<210>  2552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2552
cucaccaucu acaaaagaag                                                   20


<210>  2553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2553
acaaaagaag auuaauaauu                                                   20


<210>  2554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2554
ucuuuuguag auggugagag                                                   20


<210>  2555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2555
uuagaaaugu ccuucacaua                                                   20


<210>  2556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2556
uauaugucaa aggaagguuu                                                   20


<210>  2557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2557
aaauucagaa cugucuacuc                                                   20


<210>  2558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2558
uuguccugug acacuggcac                                                   20


<210>  2559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2559
aaaaaaugag aauaaaaccu                                                   20


<210>  2560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2560
gguuuuauuc ucauuuuuug                                                   20


<210>  2561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2561
uuuacaaauu aaagaugugc                                                   20


<210>  2562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2562
acguggacau caaaauguau                                                   20


<210>  2563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2563
ccucggcccc auaggccgaa                                                   20


<210>  2564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2564
ucaccagaaa uuucaccuca                                                   20


<210>  2565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2565
cuuaggucag cuccaucuuc                                                   20


<210>  2566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2566
gaaaacucug ucuaguauaa                                                   20


<210>  2567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2567
aaacauaaaa cuguaccaca                                                   20


<210>  2568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2568
uaauguaaca auuaagaaau                                                   20


<210>  2569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2569
guucucccaa cuaauuagaa                                                   20


<210>  2570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2570
ucuauaaugu caaucaguuc                                                   20


<210>  2571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2571
cauaugccac uuaaguaaaa                                                   20


<210>  2572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2572
cacaauaaua ugaaggaaga                                                   20


<210>  2573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2573
uucccagcca uuaaaaaagc                                                   20


<210>  2574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2574
uagagccaca cacucaaagu                                                   20


<210>  2575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2575
cacagcaaau uacauggaag                                                   20


<210>  2576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2576
cucucuguaa gugucucuuc                                                   20


<210>  2577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2577
ucagcuuccu gccguacaac                                                   20


<210>  2578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2578
gaacucccca guauuaccaa                                                   20


<210>  2579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2579
gacacccuuu gguagaaaag                                                   20


<210>  2580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2580
ucggcgcaca ucaguguaug                                                   20


<210>  2581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2581
guguaugggu uugcuuuaua                                                   20


<210>  2582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2582
guaaauaaaa guuuuucuug                                                   20


<210>  2583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2583
aaaacaaagg gcccauuauu                                                   20


<210>  2584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2584
ugacuuccau gcuaagcagu                                                   20


<210>  2585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2585
agcuaggccc acaacugaag                                                   20


<210>  2586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2586
cucacuugga agugauauag                                                   20


<210>  2587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2587
cuuccaagug agagauccag                                                   20


<210>  2588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2588
gaaaauuuua auggauaacu                                                   20


<210>  2589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2589
auuaaaauuu ucagauuucc                                                   20


<210>  2590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2590
gagagaaagu aaugaauacu                                                   20


<210>  2591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2591
auuuguaaau acuuacuuug                                                   20


<210>  2592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2592
aaguaaguau uuacaaaugg                                                   20


<210>  2593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2593
uaaacuuuug gucuauauuc                                                   20


<210>  2594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2594
cuggguucua gagggugugg                                                   20


<210>  2595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2595
gacaaacauu auaagguuaa                                                   20


<210>  2596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2596
accuccucau ccuuagcauu                                                   20


<210>  2597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2597
uuagcauuga ucucaaugua                                                   20


<210>  2598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2598
uacacagugg gcaggcacac                                                   20


<210>  2599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2599
ccacgaaaaa agguugcccu                                                   20


<210>  2600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2600
uccaccgccc ugauccacac                                                   20


<210>  2601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2601
gggcggugga ggauccccac                                                   20


<210>  2602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2602
acacuucgcc cauuuucccc                                                   20


<210>  2603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2603
uggcgagcca uuccugaaac                                                   20


<210>  2604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2604
agggaaacua uguagaagca                                                   20


<210>  2605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2605
acguuaauau ggucuuuuug                                                   20


<210>  2606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2606
uauuuaaugg agcguccgcu                                                   20


<210>  2607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2607
cauuagguga auuaccaaga                                                   20


<210>  2608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2608
uuaccuagcg ucuugguaau                                                   20


<210>  2609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2609
gaaugaucuc cauggagaaa                                                   20


<210>  2610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2610
uucagauuug cucuuuuucc                                                   20


<210>  2611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2611
ccauggagaa aauaaaacag                                                   20


<210>  2612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2612
uguuuuuuaa aaagggcaaa                                                   20


<210>  2613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2613
aggagugacu ucuugucaga                                                   20


<210>  2614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2614
gauuaggaaa uaacagaaaa                                                   20


<210>  2615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2615
gauaugagcg ugaagaagcu                                                   20


<210>  2616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2616
acaauggaau uuaaaacucu                                                   20


<210>  2617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2617
auaaguauuu agugacuuaa                                                   20


<210>  2618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2618
guugacaggg agagaguucu                                                   20


<210>  2619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2619
cuucaaaagg augaucauuu                                                   20


<210>  2620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2620
uuuugaagug auuuguuuag                                                   20


<210>  2621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2621
uccuuuugaa gugauuuguu                                                   20


<210>  2622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2622
uuuuuccugu gucggugaua                                                   20


<210>  2623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2623
ccgacacagg aaaaaugauc                                                   20


<210>  2624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2624
ucacucaccu gugaggacag                                                   20


<210>  2625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2625
guaaagacug uccucacagg                                                   20


<210>  2626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2626
ucugaucaga guagaugccc                                                   20


<210>  2627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2627
gaagaucugu aaagacuguc                                                   20


<210>  2628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2628
gaguagaugc ccugaaaugu                                                   20


<210>  2629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2629
acucugauca gaagaucugu                                                   20


<210>  2630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2630
cuuaaaacug uaacuuuuca                                                   20


<210>  2631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2631
gcugugguga auggaggcua                                                   20


<210>  2632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2632
caggugugca ccaccacgcc                                                   20


<210>  2633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2633
cagcuacucg ggaggcugag                                                   20


<210>  2634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2634
cuuguaccug gaagguagag                                                   20


<210>  2635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2635
aucugaucaa ugagacuagu                                                   20


<210>  2636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2636
gaucaaugag acuaguaaag                                                   20


<210>  2637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2637
gauggaugaa uaccucaagg                                                   20


<210>  2638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2638
augagacuag uaaagaauuc                                                   20


<210>  2639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2639
ugcuguucuc ucacauaaag                                                   20


<210>  2640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2640
ugaaaaucua uauaacaaaa                                                   20


<210>  2641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2641
auauaacaaa aauuaaaugu                                                   20


<210>  2642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2642
gguucacuau uaggaugugg                                                   20


<210>  2643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2643
uaauagugaa ccugauuuuu                                                   20


<210>  2644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2644
gcacaggguc aggggaauga                                                   20


<210>  2645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2645
uuccccugac ccugugccga                                                   20


<210>  2646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2646
uuaaaaauau ucaaaauaau                                                   20


<210>  2647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2647
uaauuauuuu gaauauuuuu                                                   20


<210>  2648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2648
uuaaaucuca agaguuacug                                                   20


<210>  2649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2649
caagaguuac ugggugaaau                                                   20


<210>  2650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2650
ucuggauugu cugugucauc                                                   20


<210>  2651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2651
ggauugucug ugucaucauc                                                   20


<210>  2652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2652
agaugauagc guguuuuacc                                                   20


<210>  2653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2653
uccacugaaa guaaugacug                                                   20


<210>  2654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2654
acugaaagua augacugcac                                                   20


<210>  2655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2655
agcuugaaau auuuaaaaug                                                   20


<210>  2656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2656
cauuagguca aguccaucug                                                   20


<210>  2657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2657
guaauacagg cagcuuauua                                                   20


<210>  2658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2658
cacauuuuua uaaaguugcu                                                   20


<210>  2659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2659
aucguaccaa aaaggauaga                                                   20


<210>  2660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2660
uaccaaaaag gauagaaaaa                                                   20


<210>  2661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2661
uuuuugguac gauagauaau                                                   20


<210>  2662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2662
ccucagggag cccagguugc                                                   20


<210>  2663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2663
acugggggaa gguacuggaa                                                   20


<210>  2664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2664
agcauguuau gaaagcuaug                                                   20


<210>  2665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2665
gcagagguac uucaugaaca                                                   20


<210>  2666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2666
gcaucugcag agguacuuca                                                   20


<210>  2667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2667
aguaauuaua uaaauaaaca                                                   20


<210>  2668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2668
uucaacaaau auugauuaaa                                                   20


<210>  2669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2669
auauuuguug aaugauaauc                                                   20


<210>  2670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2670
gccaggcacu gugcauggga                                                   20


<210>  2671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2671
uucaugguaa ucacuucgua                                                   20


<210>  2672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2672
ugaccaaucu ggauggcaaa                                                   20


<210>  2673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2673
ggauggcaaa aaaaggcuca                                                   20


<210>  2674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2674
agauugguca ggauccuuca                                                   20


<210>  2675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2675
acuaugcuuu uucuggauca                                                   20


<210>  2676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2676
uuuuccacuu gaagaagugc                                                   20


<210>  2677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2677
gacauauacu uacagcagga                                                   20


<210>  2678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2678
ugcuguaagu auaugucuga                                                   20


<210>  2679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2679
augcuuugga cuacaaauaa                                                   20


<210>  2680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2680
aacacagaua uugccuccau                                                   20


<210>  2681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2681
guguuagaua aauauuuaua                                                   20


<210>  2682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2682
aaaugguuua uaaugcuuua                                                   20


<210>  2683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2683
aucaaaacca uuuccaacuu                                                   20


<210>  2684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2684
aaaccauuuc caacuuauga                                                   20


<210>  2685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2685
uuuuaauuaa agagggagag                                                   20


<210>  2686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2686
cugaaacaua uaauuuuaag                                                   20


<210>  2687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2687
uucuaaaaaa auuaaguuca                                                   20


<210>  2688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2688
acgucuagaa aaccuacauc                                                   20


<210>  2689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2689
aacuccuugg uaagagcagg                                                   20


<210>  2690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2690
ccagccugac ccugcucuua                                                   20


<210>  2691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2691
ucaaauuauu auaaaagaac                                                   20


<210>  2692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2692
gccaacauca caaggacuuc                                                   20


<210>  2693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2693
caaggacuuc auaggcugcc                                                   20


<210>  2694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2694
gcuauucgcu guacuacacc                                                   20


<210>  2695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2695
acuuaaauua cucauuaaac                                                   20


<210>  2696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2696
acaguugaaa ugaaaguaga                                                   20


<210>  2697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2697
cugucauccu aagaagaucu                                                   20


<210>  2698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2698
uaagaagauc uuaggauggc                                                   20


<210>  2699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2699
ucuuaggaug acagcgauaa                                                   20


<210>  2700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2700
uaggauggca gcaaaagaaa                                                   20


<210>  2701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2701
uaagaucuuc uuaggaugac                                                   20


<210>  2702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2702
auucuggguu uuacagcuuu                                                   20


<210>  2703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2703
cucaguaaug caagguuagc                                                   20


<210>  2704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2704
cugguuagga aggauacaca                                                   20


<210>  2705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2705
uuccuaacca gugaucccuc                                                   20


<210>  2706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2706
ucuuuucugu guauccuucc                                                   20


<210>  2707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2707
gaacuucagg guugcaaagg                                                   20


<210>  2708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2708
cuuucuuccu ugaagguuuu                                                   20


<210>  2709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2709
acaccauuca guacaauggg                                                   20


<210>  2710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2710
cuccccauug uacugaaugg                                                   20


<210>  2711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2711
aggcacugua uaugauuuuu                                                   20


<210>  2712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2712
uauacagugc cuugauuaaa                                                   20


<210>  2713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2713
guuuuaggua agaaaaaaaa                                                   20


<210>  2714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2714
cauauaaaua uuucucuacu                                                   20


<210>  2715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2715
uaucacauau aaauauuucu                                                   20


<210>  2716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2716
uaagagguau cuuaucacau                                                   20


<210>  2717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2717
ugaagaaacu auuugcuguu                                                   20


<210>  2718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2718
aacuaacuuu guuccuuucu                                                   20


<210>  2719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2719
cuuuguaaug uugacccucc                                                   20


<210>  2720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2720
uucaaauuug uacccauaaa                                                   20


<210>  2721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2721
aauuuuguau uaguuuuaug                                                   20


<210>  2722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2722
acuaaaugaa gaaaugcaca                                                   20


<210>  2723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2723
uauauuaucc acuaaaugaa                                                   20


<210>  2724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2724
gugagucugu guauccuaua                                                   20


<210>  2725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2725
uuugggacug aaguuucaaa                                                   20


<210>  2726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2726
aaaguaugga aaaugcacgu                                                   20


<210>  2727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2727
gucaacagga cuuucaucca                                                   20


<210>  2728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2728
aacaaugguu uaaugaguga                                                   20


<210>  2729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2729
cucauuaaac cauuguuaga                                                   20


<210>  2730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2730
ucaacaugaa uauuaugcuc                                                   20


<210>  2731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2731
uugaauuaaa auauguguuc                                                   20


<210>  2732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2732
uaucuugcac uuucuuauca                                                   20


<210>  2733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2733
ugcacuuucu uaucagagca                                                   20


<210>  2734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2734
uuuuaaacua aaaaggcaag                                                   20


<210>  2735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2735
cucuuuucua uguaucccca                                                   20


<210>  2736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2736
ccaguagcca agaauauuuu                                                   20


<210>  2737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2737
cauauguacc ccaccacugg                                                   20


<210>  2738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2738
gaagaggcag ccccuaacca                                                   20


<210>  2739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2739
cccuuaaaag aagacagaca                                                   20


<210>  2740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2740
aucuuauuuu cccacuuaca                                                   20


<210>  2741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2741
uauuuuccca cuuacacaca                                                   20


<210>  2742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2742
gccaugugau aagauggagc                                                   20


<210>  2743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2743
cauggcagau ucuucagugc                                                   20


<210>  2744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2744
uaucacaugg cagauucuuc                                                   20


<210>  2745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2745
agacccuucu uucacucugu                                                   20


<210>  2746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2746
uacuggcagg gcacuuacgc                                                   20


<210>  2747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2747
uacagcugaa ugugagacca                                                   20


<210>  2748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2748
agccaaguaa ucucaucuuc                                                   20


<210>  2749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2749
caucuucaag caucguagcu                                                   20


<210>  2750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2750
ucaagcaucg uagcugggcu                                                   20


<210>  2751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2751
uagcugggcu gauccuuaac                                                   20


<210>  2752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2752
gcccagcuac gaugcuugaa                                                   20


<210>  2753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2753
uuaacugcuc cauuucugaa                                                   20


<210>  2754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2754
auuacaaaga aagaaggauu                                                   20


<210>  2755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2755
uuaaggccag gcgagcuggc                                                   20


<210>  2756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2756
guaaucccag cacuuuggga                                                   20


<210>  2757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2757
cagcacuuug ggaggcugag                                                   20


<210>  2758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2758
gcccaccuca gccucccaaa                                                   20


<210>  2759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2759
ugaggucagg aguucgagac                                                   20


<210>  2760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2760
cagcucacug caaccucugc                                                   20


<210>  2761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2761
cgccacugua cuccagacug                                                   20


<210>  2762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2762
uggcacuuug ggaggcgaag                                                   20


<210>  2763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2763
caggcguaag ccacugcgcc                                                   20


<210>  2764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2764
guuucguaag ugucugucaa                                                   20


<210>  2765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2765
gccaccauag aaauguuguu                                                   20


<210>  2766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2766
cuuucccagc accuaagucu                                                   20


<210>  2767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2767
acaaaaauag caauugguaa                                                   20


<210>  2768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2768
ugauuuuuau uuuauuaauu                                                   20


<210>  2769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2769
ggauccacaa aaauagcaau                                                   20


<210>  2770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2770
ugaguuuguu auucuccgcu                                                   20


<210>  2771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2771
gaacuaaaau uuacacagag                                                   20


<210>  2772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2772
guguaauuaa aauaugagcc                                                   20


<210>  2773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2773
acaaauguuc ucaauucauu                                                   20


<210>  2774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2774
gacaaguaag uaaaugacua                                                   20


<210>  2775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2775
ucuaauaacu ggcaucucaa                                                   20


<210>  2776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2776
aauaacuggc aucucaaauc                                                   20


<210>  2777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2777
caaaucaaaa uacuccauac                                                   20


<210>  2778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2778
aaauacucca uacacugaga                                                   20


<210>  2779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2779
caguguaugg aguauuuuga                                                   20


<210>  2780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2780
gccucuuauu aguaacugaa                                                   20


<210>  2781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2781
ugcucacuug uuuuaugaau                                                   20


<210>  2782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2782
guaugcuucu ugcuaaaaua                                                   20


<210>  2783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2783
guauuaguaa aaucaguaug                                                   20


<210>  2784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2784
aucacaucuu aaaauaauau                                                   20


<210>  2785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2785
caucuuaaaa uaauauaugc                                                   20


<210>  2786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2786
uaaaauaaua uaugcacuga                                                   20


<210>  2787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2787
ucagacuggc cuaaugaguu                                                   20


<210>  2788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2788
gcuguauauu uaugguaaua                                                   20


<210>  2789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2789
ugaugguaaa cuauaacaua                                                   20


<210>  2790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2790
agauuuaagc ugaauuagac                                                   20


<210>  2791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2791
ggaauguuaa aacagaaggu                                                   20


<210>  2792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2792
cggcuucuac auaaauauua                                                   20


<210>  2793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2793
cuguauauua gaaagugcau                                                   20


<210>  2794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2794
aaaacagagg uauuaaaaaa                                                   20


<210>  2795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2795
auucuugacu uuuuuuaaua                                                   20


<210>  2796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2796
aagaaaccag agggaaaauu                                                   20


<210>  2797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2797
cauaacacuu cuuuugauau                                                   20


<210>  2798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2798
uuucaaaaaa ccagcuccuc                                                   20


<210>  2799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2799
aggagcuggu uuuuugaaaa                                                   20


<210>  2800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2800
gugaaucgag gagcugguuu                                                   20


<210>  2801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2801
ucuucaguuc ugcucugauc                                                   20


<210>  2802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2802
gagcagaacu gaagaagaua                                                   20


<210>  2803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2803
uaguuauuuu uugccuucug                                                   20


<210>  2804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2804
caauuaaaag aacuagagaa                                                   20


<210>  2805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2805
acaauugaca cccuaacauc                                                   20


<210>  2806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2806
uuccugcuuu cuccuguggg                                                   20


<210>  2807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2807
cugggacaca gcuaaagcaa                                                   20


<210>  2808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2808
cacaacuaca uggaaacuga                                                   20


<210>  2809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2809
acagaauaua cauucuuuuc                                                   20


<210>  2810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2810
acagaacucu ccaccccaaa                                                   20


<210>  2811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2811
cugaauagac caauaacaag                                                   20


<210>  2812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2812
gguccugggc cuuuuuuggu                                                   20


<210>  2813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2813
aucugguccu gggccuuuuu                                                   20


<210>  2814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2814
cucuuauuua acauaguauu                                                   20


<210>  2815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2815
ggcaagagaa agaaauaaag                                                   20


<210>  2816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2816
gaauacccuu uauuucuuuc                                                   20


<210>  2817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2817
gcaaacagag acaguuugac                                                   20


<210>  2818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2818
ugucaucugc aaacagagac                                                   20


<210>  2819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2819
ucucucaggc caaaaucucc                                                   20


<210>  2820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2820
ccuuaagcaa cuucagcaaa                                                   20


<210>  2821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2821
ugagacuuug cugaaguugc                                                   20


<210>  2822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2822
augugcaaaa ucacaaacau                                                   20


<210>  2823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2823
caaacauucc uauacacgaa                                                   20


<210>  2824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2824
ugagugaacu cccauucaca                                                   20


<210>  2825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2825
auguugugaa aauggccacg                                                   20


<210>  2826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2826
auaaauuacu uugggcagcg                                                   20


<210>  2827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2827
ccaucaagcu accacugacu                                                   20


<210>  2828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2828
agcuaccacu gacuuucuuc                                                   20


<210>  2829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2829
uaagcaaaaa gaacaaagcu                                                   20


<210>  2830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2830
ugcuaccuga cuucaaacua                                                   20


<210>  2831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2831
uuuucuuguu uuuaauguaa                                                   20


<210>  2832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2832
uuguuauuuc uuuccuuuua                                                   20


<210>  2833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2833
augaaaccaa aaguugccuc                                                   20


<210>  2834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2834
uucucccuuu uuuguguuag                                                   20


<210>  2835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2835
aauuacuaaa cucagaaaug                                                   20


<210>  2836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2836
aaaaaaaaaa aaagaaaaga                                                   20


<210>  2837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2837
gguccagggc uuuucuuugu                                                   20


<210>  2838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2838
aaauugaaaa gggaguaaaa                                                   20


<210>  2839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2839
guuaacagau gacauguuac                                                   20


<210>  2840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2840
guuaacagau aauuuuacuc                                                   20


<210>  2841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2841
cggcucacug caagcuccgc                                                   20


<210>  2842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2842
acaauuccac uuacaauagc                                                   20


<210>  2843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2843
aaaauaauaa aauacuuagg                                                   20


<210>  2844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2844
acaaacauug cugaaagaaa                                                   20


<210>  2845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2845
uuaauuucuu ucagcaaugu                                                   20


<210>  2846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2846
uguguucaag gauugaaaga                                                   20


<210>  2847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2847
uugaacacaa gaugucuuuu                                                   20


<210>  2848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2848
ugugucacaa aguuuucccu                                                   20


<210>  2849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2849
gcaacauaca ugacagacaa                                                   20


<210>  2850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2850
ccaaacuggg aaaauaaaau                                                   20


<210>  2851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2851
gagguaggua auaaaaaugg                                                   20


<210>  2852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2852
ucacggcuca gcugccucuc                                                   20


<210>  2853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2853
guuucuucua ggcguaaucc                                                   20


<210>  2854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2854
ggaugcgcug augugucugu                                                   20


<210>  2855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2855
agaugugcag aagccaaauc                                                   20


<210>  2856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2856
gcgcauccag augugcagaa                                                   20


<210>  2857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2857
gcuguacacu cuuagucaga                                                   20


<210>  2858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2858
caggcaaccc ggcgaaucug                                                   20


<210>  2859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2859
gaaauuacau gaucagcagc                                                   20


<210>  2860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2860
uguaauuuca gauucgccgg                                                   20


<210>  2861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2861
gcagcaaagg acagacauga                                                   20


<210>  2862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2862
acauguugag acugcuuaaa                                                   20


<210>  2863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2863
uuaccucagc acuuggugau                                                   20


<210>  2864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2864
ccaagugcug agguaaggau                                                   20


<210>  2865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2865
gagcagaaua ucaaugauga                                                   20


<210>  2866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2866
augaugaaau cagcaacaca                                                   20


<210>  2867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2867
uugauauucu gcucggauca                                                   20


<210>  2868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2868
gcaacacagg gcaaguuaua                                                   20


<210>  2869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2869
uucuauaacu ugcccugugu                                                   20


<210>  2870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2870
cccauuucuu cuuauuagca                                                   20


<210>  2871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2871
aaauuugaaa augcauuacc                                                   20


<210>  2872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2872
aggcaagaca uuuauucugu                                                   20


<210>  2873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2873
auaguugcaa acuauaaaau                                                   20


<210>  2874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2874
uuuguaaguu uauuuuaagg                                                   20


<210>  2875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2875
guuaucauuu guaaguuuau                                                   20


<210>  2876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2876
uuacaagggg guggacacug                                                   20


<210>  2877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2877
ucuugcuucu gccuugcagu                                                   20


<210>  2878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2878
aggaagaaau guaaagaauu                                                   20


<210>  2879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2879
cuuucaggga aaggccaagu                                                   20


<210>  2880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2880
caaacaagcc uccagcauac                                                   20


<210>  2881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2881
gcgagucuuu gguggauaca                                                   20


<210>  2882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2882
accaaagacu cgcugauugc                                                   20


<210>  2883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2883
guguucgaca acagucugua                                                   20


<210>  2884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2884
acaguaaauu ucugcuuacc                                                   20


<210>  2885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2885
uacaggaacu augcaauauu                                                   20


<210>  2886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2886
aaauguguuc acaaggcaaa                                                   20


<210>  2887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2887
ccugaaauua guuuugccuu                                                   20


<210>  2888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2888
cuauuuuaga aauaccucaa                                                   20


<210>  2889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2889
uuguggcaau aauacaaauu                                                   20


<210>  2890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2890
acaguuuuua gcuuagcuga                                                   20


<210>  2891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2891
agcucuguau acacuuagua                                                   20


<210>  2892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2892
guaccugaac ugcugagucu                                                   20


<210>  2893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2893
uguugggagu agccagccaa                                                   20


<210>  2894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2894
agccguccug cagccgcagc                                                   20


<210>  2895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2895
caugaagcaa gccacaguag                                                   20


<210>  2896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2896
cuuacuucca uugucuaaag                                                   20


<210>  2897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2897
cuuacuugua uugcaacucg                                                   20


<210>  2898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2898
cugcugcucg aguugcaaua                                                   20


<210>  2899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2899
ucccugcugc ucgaguugca                                                   20


<210>  2900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2900
gacacggaca acugucggua                                                   20


<210>  2901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2901
uaccgacagu uguccguguc                                                   20


<210>  2902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2902
gucugcuugu cugccggcug                                                   20


<210>  2903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2903
uuggugaggu cuucaucuaa                                                   20


<210>  2904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2904
aauaacgugg gcauuguuug                                                   20


<210>  2905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2905
uaaaaagaaa cagcuagacu                                                   20


<210>  2906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2906
gucuacagcu ugcaagguau                                                   20


<210>  2907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2907
gaaguagacu augaaacaag                                                   20


<210>  2908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2908
caucagaagu agacuaugaa                                                   20


<210>  2909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2909
ugccuuuuuu ucuucuuuuu                                                   20


<210>  2910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2910
gucaucauca auuacuuagu                                                   20


<210>  2911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2911
ucaauuacuu aguuucuaca                                                   20


<210>  2912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2912
auuacuuagu uucuacauga                                                   20


<210>  2913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2913
uucaaugguu uccuauuucc                                                   20


<210>  2914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2914
ccuucagguc uuugcuagau                                                   20


<210>  2915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2915
agcaaagacc ugaaggagau                                                   20


<210>  2916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2916
ggaaaagcuu cgcuggggug                                                   20


<210>  2917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2917
cccuacugaa aaucauagcc                                                   20


<210>  2918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2918
cucagccauu uacagggcug                                                   20


<210>  2919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2919
ucugcucaug cuuugagcug                                                   20


<210>  2920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2920
uuugcuugaa caccaggcaa                                                   20


<210>  2921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2921
ccugucuugg gaaccucagu                                                   20


<210>  2922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2922
gcugccucuc aaaggcagag                                                   20


<210>  2923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2923
cugccuuuga gaggcagcug                                                   20


<210>  2924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2924
aauuuaucuu ugcaucccca                                                   20


<210>  2925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2925
guuucuuuug ugucucaugu                                                   20


<210>  2926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2926
uucugugaaa acuuccucaa                                                   20


<210>  2927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2927
ucagcuguug gcaugaguuu                                                   20


<210>  2928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2928
gcuguuggca ugaguuugga                                                   20


<210>  2929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2929
guucccuagg uucuaagcuc                                                   20


<210>  2930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2930
acacauuuuc agcagaaauu                                                   20


<210>  2931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2931
ugaaacauca gcuucuacau                                                   20


<210>  2932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2932
cauuuucccu auucuauuua                                                   20


<210>  2933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2933
uuccguucua gagaaagcug                                                   20


<210>  2934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2934
agcauaucac augaaauuau                                                   20


<210>  2935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2935
uucuaaagaa uauaucuagc                                                   20


<210>  2936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2936
ugcauuuuua auauaugggc                                                   20


<210>  2937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2937
uaacuuaaua agcaguuguu                                                   20


<210>  2938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2938
aaggaauuca caccuacuca                                                   20


<210>  2939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2939
caagaugcaa auucuuuagg                                                   20


<210>  2940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2940
ugugauuccu gccagaucug                                                   20


<210>  2941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2941
guuuauuaaa cagggugaac                                                   20


<210>  2942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2942
uuccugugaa aagacauguu                                                   20


<210>  2943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2943
caccuugaag caguaagaua                                                   20


<210>  2944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2944
uacugcuuca aggugugaug                                                   20


<210>  2945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2945
aggcacuaaa gaauagaauc                                                   20


<210>  2946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2946
uucagggcuu uauuuucuuc                                                   20


<210>  2947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2947
uuugccccgg gaaugucuac                                                   20


<210>  2948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2948
aaacagacuu ucuaaaauug                                                   20


<210>  2949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2949
aagcaacagc accagccaag                                                   20


<210>  2950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2950
cugucaucaa agcaacagca                                                   20


<210>  2951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2951
ccaucccugu caucaaagca                                                   20


<210>  2952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2952
aguucucagu ccucaaaauc                                                   20


<210>  2953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2953
cuaaauacug auaauaaaau                                                   20


<210>  2954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2954
guauuuagag auacaaauuu                                                   20


<210>  2955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2955
uauaauuuua uuaucaguau                                                   20


<210>  2956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2956
guuaagcuaa uacuagugau                                                   20


<210>  2957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2957
auuuauucug agaacauaau                                                   20


<210>  2958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2958
auaauauugu uuaauuaugu                                                   20


<210>  2959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2959
cuuaaggaac aacauucuaa                                                   20


<210>  2960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2960
acugugaaaa aauuaaauga                                                   20


<210>  2961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2961
uuuaauuuuu ucacaguuga                                                   20


<210>  2962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2962
auuuauauua gcaacucaga                                                   20


<210>  2963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2963
uugcguaugu cugaguugcu                                                   20


<210>  2964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2964
gauucaaaga ggcaucaugg                                                   20


<210>  2965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2965
gaucauugcg uaugucugag                                                   20


<210>  2966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2966
uggguaauga aaaacgucuc                                                   20


<210>  2967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2967
caacuagagu cugaucuggg                                                   20


<210>  2968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2968
gacucuaguu gugauucagu                                                   20


<210>  2969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2969
gggacaagua acuucauccc                                                   20


<210>  2970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2970
uccuaccuca gccuccugag                                                   20


<210>  2971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2971
caccagcuaa uuuuuuuauu                                                   20


<210>  2972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2972
caauucagug agugaaaaua                                                   20


<210>  2973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2973
aguugaucaa gggcuuccug                                                   20


<210>  2974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2974
acuugauucu uuaggaagaa                                                   20


<210>  2975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2975
agggcuuccu gaauggcugg                                                   20


<210>  2976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2976
agccauucag gaagcccuug                                                   20


<210>  2977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2977
guggguauca agagcagaag                                                   20


<210>  2978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2978
agagcagaag cuuccguacu                                                   20


<210>  2979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2979
ugaaguuuuu caaauacaaa                                                   20


<210>  2980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2980
ggaagagcca agguaaauau                                                   20


<210>  2981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2981
gcucgccaau cuggaagagc                                                   20


<210>  2982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2982
cuacaccagg gagggauuuc                                                   20


<210>  2983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2983
cucccuggug uagugauggc                                                   20


<210>  2984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2984
ggagaaaucc cucccuggug                                                   20


<210>  2985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2985
cucccccugu ucucuacugg                                                   20


<210>  2986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2986
cuuuuaugca guuauaacca                                                   20


<210>  2987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2987
gaaucucuuu uaugcaguua                                                   20


<210>  2988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2988
gacaucauua cacaacguau                                                   20


<210>  2989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2989
uuacacaacg uauuuacaag                                                   20


<210>  2990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2990
ucccacuugu aaauacguug                                                   20


<210>  2991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2991
ugaauuuauu aaaaaucuuc                                                   20


<210>  2992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2992
ucaaguuuaa uaauuuuuaa                                                   20


<210>  2993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2993
uucugagugg gguuucuuuu                                                   20


<210>  2994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2994
aagaacucuu caaguuuagu                                                   20


<210>  2995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2995
cucuaguaag guuuaugcuc                                                   20


<210>  2996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2996
uuuuaauuua cagagcauaa                                                   20


<210>  2997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2997
auauuucaau gacuucauga                                                   20


<210>  2998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2998
uguucuaggc acuguuuuag                                                   20


<210>  2999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  2999
cgaauugagc uccuuauacc                                                   20


<210>  3000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3000
uaauuuaucc cgaauugagc                                                   20


<210>  3001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3001
cuuaaguguc uacuaggcac                                                   20


<210>  3002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3002
acuuaacauc ucuuaagugu                                                   20


<210>  3003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3003
auccacuuaa caucucuuaa                                                   20


<210>  3004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3004
auuuauuuca gguuaaaacu                                                   20


<210>  3005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3005
gcaaagcucc uugaaacagu                                                   20


<210>  3006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3006
cacuuacacc uucaguuacu                                                   20


<210>  3007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3007
auuuccauuu aaaaacaaga                                                   20


<210>  3008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3008
cccaguaccu gcuccauggc                                                   20


<210>  3009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3009
gcugaacucc cagauggggu                                                   20


<210>  3010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3010
gggaguucag cagauucuuc                                                   20


<210>  3011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3011
uuacagugaa gacuucuggc                                                   20


<210>  3012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3012
gaaaagccca guugguggag                                                   20


<210>  3013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3013
aaagcuacuc caccaacugg                                                   20


<210>  3014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3014
uuauucacug ucagcugcaa                                                   20


<210>  3015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3015
uuuauuauuc aucaaaacug                                                   20


<210>  3016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3016
aaacugcuua uuuaaaccua                                                   20


<210>  3017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3017
uuuguaaaua ucuguauauu                                                   20


<210>  3018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3018
guauauuauc cacaggagag                                                   20


<210>  3019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3019
acaggagagc acaacugcuu                                                   20


<210>  3020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3020
gcuuguaccc cacaguuuca                                                   20


<210>  3021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3021
uugguagacu cauagguaac                                                   20


<210>  3022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3022
uuuaacccuu aauguuaccu                                                   20


<210>  3023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3023
uuaaaaaacg aauaagucaa                                                   20


<210>  3024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3024
gacuugacuu auucguuuuu                                                   20


<210>  3025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3025
cuugagucca gccuaagcaa                                                   20


<210>  3026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3026
uaaaaaaagg aaguggcuua                                                   20


<210>  3027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3027
cuauagaggu aagccacuuc                                                   20


<210>  3028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3028
cauagcgcuc ugccagaagc                                                   20


<210>  3029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3029
cucaauuauu acaaguuuag                                                   20


<210>  3030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3030
acuaaacuug uaauaauuga                                                   20


<210>  3031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3031
auagauuaaa aaaaaaaagu                                                   20


<210>  3032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3032
auagaucuac uaaacuugua                                                   20


<210>  3033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3033
cacuucaaau acauuuuaau                                                   20


<210>  3034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3034
ucacacuuca aauacauuuu                                                   20


<210>  3035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3035
gagcucaguu cuagucuguu                                                   20


<210>  3036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3036
uauaacuaaa auaugauaua                                                   20


<210>  3037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3037
uauuuuaguu auaagauaaa                                                   20


<210>  3038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3038
gacaaaguuc ugaacugccu                                                   20


<210>  3039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3039
guaaguacga cacaaacaaa                                                   20


<210>  3040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3040
auaauuguuc caacuugggg                                                   20


<210>  3041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3041
cauuucacua guuuggaaag                                                   20


<210>  3042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3042
uuucauauuu gguggacuac                                                   20


<210>  3043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3043
ugaguugaau cuaucauuac                                                   20


<210>  3044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3044
aucauuacuu cugccauuua                                                   20


<210>  3045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3045
uuacuucugc cauuuaaaaa                                                   20


<210>  3046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3046
aagcaaugag uccuuucuuc                                                   20


<210>  3047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3047
cguugugaau aagaauagcc                                                   20


<210>  3048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3048
cuagagggca gcagcagagu                                                   20


<210>  3049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3049
cauugcuguu uuuugaguuu                                                   20


<210>  3050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3050
ccaaauguuu gugugaaaac                                                   20


<210>  3051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3051
uagucacuaa aauauuauuc                                                   20


<210>  3052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3052
uaugcaagca uaaugcauac                                                   20


<210>  3053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3053
ucuucuacuu cauucugcuu                                                   20


<210>  3054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3054
ucuacuucau ucugcuuacc                                                   20


<210>  3055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3055
aauaaaaacu aaaacaagaa                                                   20


<210>  3056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3056
ccaggaccac ccgaguacuu                                                   20


<210>  3057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3057
gugccucuuu ggaaguucug                                                   20


<210>  3058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3058
gaagugaaaa auacacaaca                                                   20


<210>  3059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3059
cuuaccuaua aggagacuga                                                   20


<210>  3060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3060
ggguuucuca accuggacuc                                                   20


<210>  3061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3061
aaauauguca uuauaaaaaa                                                   20


<210>  3062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3062
aagcaaaaau guuccaaaag                                                   20


<210>  3063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3063
acugaauaug aauguuuaag                                                   20


<210>  3064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3064
cuuuuauuuc cagcaugacg                                                   20


<210>  3065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3065
agccacaaac aucaacauua                                                   20


<210>  3066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3066
acauuauaaa uuaucuaaaa                                                   20


<210>  3067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3067
aaaaauauaa aauuaugaaa                                                   20


<210>  3068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3068
cuuugaggua aaugcuuuuu                                                   20


<210>  3069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3069
uguguagcaa ucagcaauga                                                   20


<210>  3070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3070
gcaaugaauu ucuuauguaa                                                   20


<210>  3071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3071
uuacauaaga aauucauugc                                                   20


<210>  3072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3072
ugaaagagua uauggaaauu                                                   20


<210>  3073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3073
uuauucagga caaaauauca                                                   20


<210>  3074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3074
aaauaaagaa gccaauuuuu                                                   20


<210>  3075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3075
auauacaaaa aagcagaaaa                                                   20


<210>  3076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3076
aaggaaagaa guuauccaua                                                   20


<210>  3077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3077
aggauuuaga uuaauguaac                                                   20


<210>  3078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3078
uagauuaaag aagguaggua                                                   20


<210>  3079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3079
aaauccuaga uuaaagaagg                                                   20


<210>  3080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3080
uaaacuauag uuacauuaau                                                   20


<210>  3081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3081
ggugauucca uggcuauuuu                                                   20


<210>  3082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3082
ccugaugaag aaauugcuaa                                                   20


<210>  3083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3083
auuccuauca auuccagcuu                                                   20


<210>  3084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3084
auuccagcuu uucuacauac                                                   20


<210>  3085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3085
agaucacaaa guuacaaaau                                                   20


<210>  3086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3086
ugauaugcuu uauaauuuaa                                                   20


<210>  3087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3087
caaaguuaca aaaucacaga                                                   20


<210>  3088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3088
ugaguccaca ccucuucagu                                                   20


<210>  3089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3089
guauaauauu auuuucauau                                                   20


<210>  3090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3090
aguauaacuu gauauucagc                                                   20


<210>  3091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3091
aaacuaucua gauuugagaa                                                   20


<210>  3092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3092
agauuugaga auaacguacu                                                   20


<210>  3093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3093
agauaguuug gauaaucuag                                                   20


<210>  3094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3094
augaucacaa agauucacau                                                   20


<210>  3095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3095
auugaaaaga caaggagcuc                                                   20


<210>  3096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3096
ucgauugaaa agacaaggag                                                   20


<210>  3097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3097
caaagauuca cauuuucaaa                                                   20


<210>  3098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3098
uugugaucau cgauugaaaa                                                   20


<210>  3099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3099
ucaacaauac uuguuauuau                                                   20


<210>  3100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3100
caccagcaau auaugagggu                                                   20


<210>  3101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3101
gacuucuaga uauacaucca                                                   20


<210>  3102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3102
agaagucaga uuguucugac                                                   20


<210>  3103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3103
aagagaaaug caaacucgua                                                   20


<210>  3104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3104
aauugccaaa uugucuuuuu                                                   20


<210>  3105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3105
agcaggccau augauuuaaa                                                   20


<210>  3106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3106
uauggccugc uagaucaaau                                                   20


<210>  3107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3107
uauaauuagu uuuuaaauca                                                   20


<210>  3108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3108
uuuuuuucag uacuuuuaag                                                   20


<210>  3109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3109
cuaugaaugg uaggaaaaaa                                                   20


<210>  3110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3110
cucucaagau caugcugucc                                                   20


<210>  3111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3111
ugagagugau guucagcagc                                                   20


<210>  3112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3112
ugcuguccuu uuguaaacca                                                   20


<210>  3113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3113
guggaauaag acgaauauca                                                   20


<210>  3114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3114
cccuauaacu aagauccauu                                                   20


<210>  3115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3115
uaguuauagg gugauauucg                                                   20


<210>  3116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3116
auuucaggca cauacauauu                                                   20


<210>  3117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3117
acaauaccac cuucuuaccu                                                   20


<210>  3118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3118
aauucacaaa cauccuggcc                                                   20


<210>  3119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3119
uggccaguua caagacacuc                                                   20


<210>  3120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3120
gggagugucu uguaacuggc                                                   20


<210>  3121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3121
ccuuggcacg auuccagccc                                                   20


<210>  3122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3122
ugccaaggag aucugggagu                                                   20


<210>  3123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3123
gggcuggaau cgugccaagg                                                   20


<210>  3124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3124
aaaauuucua gcguuuuucu                                                   20


<210>  3125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3125
ugaagcaaaa acacaaggcc                                                   20


<210>  3126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3126
ggccuugugu uuuugcuuca                                                   20


<210>  3127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3127
acuagugucg agccacuuaa                                                   20


<210>  3128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3128
gcuugcagcu gcuguggccg                                                   20


<210>  3129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3129
cuugucaucg gcuugcagcu                                                   20


<210>  3130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3130
aacuucccgu uaccaauuuc                                                   20


<210>  3131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3131
aaagcaagac aagguaaggg                                                   20


<210>  3132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3132
ccaguuugua ugggugguac                                                   20


<210>  3133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3133
cagcuuaaua auccccaguu                                                   20


<210>  3134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3134
gcuguuuauu ucuaaauuua                                                   20


<210>  3135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3135
gguuuacugu uacacauuuu                                                   20


<210>  3136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3136
ccaugcacuc auaauucagu                                                   20


<210>  3137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3137
acuccuguuu gcaguucuua                                                   20


<210>  3138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3138
gcaaaaaaca gacaacaagg                                                   20


<210>  3139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3139
ucugaaguug cuaauuccuu                                                   20


<210>  3140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3140
auccucugaa guugcuaauu                                                   20


<210>  3141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3141
guuuauuuug ugucaacaug                                                   20


<210>  3142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3142
aaguuaagcu uuggccauca                                                   20


<210>  3143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3143
uagaaagcaa uauucuuacu                                                   20


<210>  3144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3144
uagucauaua aucauagaaa                                                   20


<210>  3145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3145
uugguauccu agucauauaa                                                   20


<210>  3146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3146
uaucauuggu auccuaguca                                                   20


<210>  3147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3147
agacacuggu aguggucuaa                                                   20


<210>  3148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3148
guauuuccua guuaaaacac                                                   20


<210>  3149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3149
agaucgucau aguacagauc                                                   20


<210>  3150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3150
ggauugucau auaccaguuu                                                   20


<210>  3151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3151
ucauaguaca gaucuaaaaa                                                   20


<210>  3152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3152
uucaaacuau gaaauuucaa                                                   20


<210>  3153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3153
cacuauugaa uauguaaaug                                                   20


<210>  3154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3154
cuaugaggca aggaaaaaag                                                   20


<210>  3155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3155
gccaauccuc aaucagcaaa                                                   20


<210>  3156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3156
ucaaucagca aauacuguau                                                   20


<210>  3157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3157
gcaaauacug uauuuccuag                                                   20


<210>  3158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3158
aggaaauaca guauuugcug                                                   20


<210>  3159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3159
uugucuuaga aucuaggaaa                                                   20


<210>  3160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3160
gaaauugaca cuuuagacaa                                                   20


<210>  3161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3161
acaugccuca aaauuauaca                                                   20


<210>  3162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3162
gagaugcagg gugcaaucac                                                   20


<210>  3163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3163
cagauuuaau aaacuugcaa                                                   20


<210>  3164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3164
cuggcaucuu agaaucacag                                                   20


<210>  3165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3165
uagaaucaca gaaauaaggu                                                   20


<210>  3166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3166
cagaaauaag guauauauua                                                   20


<210>  3167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3167
aaacagauac cuucccaaaa                                                   20


<210>  3168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3168
guuuggauau aaaccuuaca                                                   20


<210>  3169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3169
uuuugggaag guaucuguuu                                                   20


<210>  3170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3170
ugauggccaa uuaagucaau                                                   20


<210>  3171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3171
ugauacuuuu uaauauauuu                                                   20


<210>  3172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3172
uuugaaggua acuuguuaua                                                   20


<210>  3173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3173
gaaauaauuc uuaaauuuua                                                   20


<210>  3174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3174
uuccuguuug cuaaacuuua                                                   20


<210>  3175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3175
uaucuaugac guggugacaa                                                   20


<210>  3176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3176
augacguggu gacaaguuau                                                   20


<210>  3177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3177
ucauuguaau uggagaagag                                                   20


<210>  3178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3178
gauaauguca cagaguggag                                                   20


<210>  3179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3179
gauaucuuca uuguaauugg                                                   20


<210>  3180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3180
ccacucugug acauuaucag                                                   20


<210>  3181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3181
gguccuacuu augaaaucuc                                                   20


<210>  3182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3182
caucaggucc uacuuaugaa                                                   20


<210>  3183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with ATCN PAM

<400>  3183
aauguugagu ccaauuuaga                                                   20


<210>  3184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3184
gaugggaccc aagguggucu                                                   20


<210>  3185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3185
gaugauucag augggaccca                                                   20


<210>  3186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3186
cuaugacauu cugaugauuc                                                   20


<210>  3187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3187
gauccuuuug auuauuucuc                                                   20


<210>  3188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3188
agcgcaaagc ugaggaugac                                                   20


<210>  3189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3189
cagaugguca uccucagcuu                                                   20


<210>  3190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3190
auuuagaguc uguguuuccc                                                   20


<210>  3191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3191
uaccacagag augacacaau                                                   20


<210>  3192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3192
gacugucauu gugucaucuc                                                   20


<210>  3193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3193
ucuccuagga uacaacuuuu                                                   20


<210>  3194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3194
uccagaagag cccaguuuca                                                   20


<210>  3195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3195
agaagagccc aguuucacca                                                   20


<210>  3196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3196
ggaagaagau gcccaauagu                                                   20


<210>  3197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3197
ccaugguuga agacuugcuu                                                   20


<210>  3198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3198
accaugguga aacugggcuc                                                   20


<210>  3199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3199
caguccaacc cauuccugaa                                                   20


<210>  3200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3200
ugaaucugug uaauuguccc                                                   20


<210>  3201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3201
ggaauggguu ggacugagaa                                                   20


<210>  3202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3202
ucuuaacuaa gcacuuacca                                                   20


<210>  3203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3203
cuuccuuucu uccuaguuuc                                                   20


<210>  3204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3204
uuccuuacua uaucgagaac                                                   20


<210>  3205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3205
uuacuauauc gagaacuuuc                                                   20


<210>  3206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3206
cgauauagua aggaaagaaa                                                   20


<210>  3207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3207
ucuucucacu uaaaggaagc                                                   20


<210>  3208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3208
ucucacuuaa aggaagcacu                                                   20


<210>  3209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3209
cacuuaaagg aagcacucuc                                                   20


<210>  3210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3210
uuuaagugag aagaagaaag                                                   20


<210>  3211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3211
gggagaccug ugaggagagu                                                   20


<210>  3212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3212
uccuccaugu ggcaccgagu                                                   20


<210>  3213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3213
cucucauuua gacauucuuc                                                   20


<210>  3214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3214
ucagaacuca gcucaaaagu                                                   20


<210>  3215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3215
gaacucagcu caaaaguuac                                                   20


<210>  3216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3216
gaagaauguc uaaaugagag                                                   20


<210>  3217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3217
ucaaggaagc cuuuccugac                                                   20


<210>  3218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3218
uugaggaagu aacuuuugag                                                   20


<210>  3219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3219
ugacauugcc cacauuagaa                                                   20


<210>  3220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3220
acauuuuugg guaucuuuac                                                   20


<210>  3221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3221
aaaguugcuu ccacauuuuu                                                   20


<210>  3222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3222
gccuguuacc caguuccaaa                                                   20


<210>  3223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3223
aacuucugcc uguuacccag                                                   20


<210>  3224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3224
gagcccugca aacuguucca                                                   20


<210>  3225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3225
ucugagcccu gcaaacuguu                                                   20


<210>  3226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3226
ugucuucuuc ugagcccugc                                                   20


<210>  3227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3227
cacauuuucc ugucuucuuc                                                   20


<210>  3228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3228
aaacuuuccc acauuuuccu                                                   20


<210>  3229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3229
uagagacuug uugaauggcu                                                   20


<210>  3230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3230
acaagucucu aggaaguucc                                                   20


<210>  3231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3231
uuguccauau uauuauuagc                                                   20


<210>  3232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3232
ucaucuccau cugagacuac                                                   20


<210>  3233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3233
caacaaguuc cucaucucca                                                   20


<210>  3234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3234
acaaaucucu aaggcagggg                                                   20


<210>  3235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3235
aaguuccaca aaucucuaag                                                   20


<210>  3236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3236
aguucaaagu uccacaaauc                                                   20


<210>  3237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3237
agaggugacu ugggugcugu                                                   20


<210>  3238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3238
guuuuaaaau gaaguagagc                                                   20


<210>  3239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3239
uuuuaaaacu gaaugcuuuu                                                   20


<210>  3240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3240
gaaaauuugc agcuugauaa                                                   20


<210>  3241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3241
gaacuuuuau gcucuacuuc                                                   20


<210>  3242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3242
auuguauuau caagcugcaa                                                   20


<210>  3243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3243
uuucuauugu auuaucaagc                                                   20


<210>  3244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3244
gagaagaaau ucaaacuggc                                                   20


<210>  3245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3245
cagaaaaugg guuuuucuuu                                                   20


<210>  3246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3246
ucucagaaaa uggguuuuuc                                                   20


<210>  3247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3247
aacuggcugc agaaauuugc                                                   20


<210>  3248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3248
gcagccaguu ugaauuucuu                                                   20


<210>  3249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3249
cuccaugucu cacagccggg                                                   20


<210>  3250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3250
ggccccacuu acaguuucuu                                                   20


<210>  3251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3251
ucauugaauu uaucuguuug                                                   20


<210>  3252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3252
uugaauuuau cuguuugaaa                                                   20


<210>  3253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3253
augaagaaac uguaaguggg                                                   20


<210>  3254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3254
aacagauaaa uucaaugaag                                                   20


<210>  3255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3255
aauaaucaua uaaauauaua                                                   20


<210>  3256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3256
ccauguugcc caggcagguc                                                   20


<210>  3257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3257
acuaauaaaa gauauacuca                                                   20


<210>  3258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3258
uauuccacua auaaaagaua                                                   20


<210>  3259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3259
gacggauuuc accaagucuu                                                   20


<210>  3260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3260
ccaagucuuu uaagucauug                                                   20


<210>  3261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3261
uuuuuaaccc caagagcuca                                                   20


<210>  3262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3262
aagcuaacuu uaguguucau                                                   20


<210>  3263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3263
uuuuaggaaa cuaaggagaa                                                   20


<210>  3264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3264
uaaaaugaac acuaaaguua                                                   20


<210>  3265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3265
ccuuaguuuc cuaaaaugaa                                                   20


<210>  3266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3266
aaauuggguu uuaacagcgc                                                   20


<210>  3267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3267
ucuucuaaau uggguuuuaa                                                   20


<210>  3268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3268
ugagacaaaa ucuuucucua                                                   20


<210>  3269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3269
cuauugccca ggcuggagua                                                   20


<210>  3270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3270
uuuugccaca gaguuaaaca                                                   20


<210>  3271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3271
acugccauac ccucccaucu                                                   20


<210>  3272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3272
ccccaucacu cccugccaag                                                   20


<210>  3273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3273
uugguuucug gaaaggagaa                                                   20


<210>  3274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3274
ggaaaggaga aaugacagug                                                   20


<210>  3275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3275
agaaaccaag gaagugccuc                                                   20


<210>  3276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3276
ccuuuccaga aaccaaggaa                                                   20


<210>  3277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3277
ugccuucuua augagaaagc                                                   20


<210>  3278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3278
uaaugagaaa gcuuucguaa                                                   20


<210>  3279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3279
uaacaaacug guggcuucuc                                                   20


<210>  3280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3280
caguguguuu gcagcugcuc                                                   20


<210>  3281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3281
ccuguggcuc acggggccug                                                   20


<210>  3282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3282
caggccccgu gagccacagg                                                   20


<210>  3283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3283
auucuaccau gcugcaacua                                                   20


<210>  3284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3284
accaugcugc aacuaucccu                                                   20


<210>  3285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3285
caggcugcgg gagggauagu                                                   20


<210>  3286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3286
aagaacaaau aaaggcccuc                                                   20


<210>  3287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3287
uggaauccua cccuguuucc                                                   20


<210>  3288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3288
gcgucagagu uuuuaaagau                                                   20


<210>  3289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3289
gaagugggga gugcugguug                                                   20


<210>  3290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3290
gaagccccua ccugccaaau                                                   20


<210>  3291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3291
gccaucccac ccagaaacag                                                   20


<210>  3292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3292
agcacuaguc uuagcuuuua                                                   20


<210>  3293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3293
gccuaauuuu acccagcucc                                                   20


<210>  3294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3294
cagaagguua ggcauucuaa                                                   20


<210>  3295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3295
gggaaugcag gccaguaggu                                                   20


<210>  3296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3296
aagucacagg augagauacg                                                   20


<210>  3297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3297
ugacguuacc guggcauuug                                                   20


<210>  3298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3298
cuuuuuagac cauauagggu                                                   20


<210>  3299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3299
ugccuucccu uuuuagacca                                                   20


<210>  3300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3300
ucaagaaaua acuauaaaaa                                                   20


<210>  3301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3301
ugaugaaaug cuaaacaaag                                                   20


<210>  3302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3302
gucuuggaga gcugaaguca                                                   20


<210>  3303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3303
ccaggaccag ccaaccuaau                                                   20


<210>  3304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3304
aaaugucaca ugguuuccug                                                   20


<210>  3305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3305
ugcaggucua ggccuuugca                                                   20


<210>  3306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3306
ucuuuggaga gagacaccaa                                                   20


<210>  3307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3307
uuggagagag acaccaagug                                                   20


<210>  3308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3308
ucgacucugc uaagccagag                                                   20


<210>  3309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3309
gagcacaugc ucacggccac                                                   20


<210>  3310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3310
auucccagcu cuacuucuug                                                   20


<210>  3311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3311
cagcucuacu ucuuguuaaa                                                   20


<210>  3312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3312
uguuaaagcu auguccacuu                                                   20


<210>  3313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3313
gagaucaugc ugccuuauua                                                   20


<210>  3314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3314
agaccugacu aagauguccc                                                   20


<210>  3315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3315
cucuucaaga ccugacuaag                                                   20


<210>  3316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3316
cuggauaagg aggagggaaa                                                   20


<210>  3317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3317
cuccuccuua uccagagaac                                                   20


<210>  3318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3318
gggcaggagg aacaacgugu                                                   20


<210>  3319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3319
uccugcccag aaugccuuuc                                                   20


<210>  3320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3320
aaaaguugac uuuuuauuga                                                   20


<210>  3321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3321
auaaaaaguc aacuuuuuga                                                   20


<210>  3322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3322
ucuacagaug cuuuuggauu                                                   20


<210>  3323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3323
uccuguuuuu auuuauuuuc                                                   20


<210>  3324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3324
uguuuuuauu uauuuuccuu                                                   20


<210>  3325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3325
uuaccuuauu gcacuagcga                                                   20


<210>  3326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3326
ucaucucagu gggaaaacuu                                                   20


<210>  3327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3327
cacugagaug aggaaagaga                                                   20


<210>  3328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3328
auauuucacu auuaauuaaa                                                   20


<210>  3329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3329
cuauuaauua aaauauuugc                                                   20


<210>  3330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3330
guguuuaggc auuguccacc                                                   20


<210>  3331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3331
ggccaugguu ggugaaacua                                                   20


<210>  3332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3332
ccaaccaugg ccagaaaccu                                                   20


<210>  3333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3333
cauauggagg ugccuaaccg                                                   20


<210>  3334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3334
cucgguaccu ggguguaauc                                                   20


<210>  3335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3335
cuccagagcc uacuaugagc                                                   20


<210>  3336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3336
aagaagggag ccugguuaau                                                   20


<210>  3337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3337
uagaacagca gcacaaaagc                                                   20


<210>  3338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3338
ccagacucca aagagugcug                                                   20


<210>  3339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3339
aagcuauugg aucuuuguuu                                                   20


<210>  3340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3340
cacagcaaua caaagacaug                                                   20


<210>  3341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3341
cauuucucac agcaauacaa                                                   20


<210>  3342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3342
ucuucaaaga uuauaaaaag                                                   20


<210>  3343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3343
ucaaagauua uaaaaaguca                                                   20


<210>  3344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3344
aagauuauaa aaagucauaa                                                   20


<210>  3345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3345
ucuuauaaca cuguuaacca                                                   20


<210>  3346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3346
uauaacacug uuaaccacua                                                   20


<210>  3347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3347
uccuuaacua ucccuagaua                                                   20


<210>  3348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3348
uuaacuaucc cuagauaacu                                                   20


<210>  3349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3349
uuuucuuucu uuguucuguu                                                   20


<210>  3350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3350
uucuuuguuc uguuccccuu                                                   20


<210>  3351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3351
uuguucuguu ccccuuaccu                                                   20


<210>  3352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3352
guuccccuua ccuaauuaag                                                   20


<210>  3353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3353
ccuuaccuaa uuaagaaagu                                                   20


<210>  3354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3354
uaauuaggua aggggaacag                                                   20


<210>  3355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3355
uuuuauaaau uacucacauu                                                   20


<210>  3356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3356
gccuaguaau uuuggggguc                                                   20


<210>  3357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3357
cuucagccua guaauuuugg                                                   20


<210>  3358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3358
auucaaaguc ucacuaagau                                                   20


<210>  3359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3359
aagucucacu aagauaaaug                                                   20


<210>  3360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3360
aaaggaggca guuagauaug                                                   20


<210>  3361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3361
ugccuuucca gacagaacca                                                   20


<210>  3362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3362
agacagaacc aauguucauu                                                   20


<210>  3363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3363
gucuggaaag gcaggaaaac                                                   20


<210>  3364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3364
uuuuacauau guuaauuaau                                                   20


<210>  3365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3365
cuuuuaacaa gggaggcaug                                                   20


<210>  3366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3366
uucacuuuua acaagggagg                                                   20


<210>  3367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3367
guacucaauu cuuucacuuu                                                   20


<210>  3368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3368
acaauuuuag aaacauauuu                                                   20


<210>  3369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3369
uaucuauaaa ugcccauauc                                                   20


<210>  3370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3370
ggauuucuug cuuuuuaggg                                                   20


<210>  3371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3371
ugcuuuuuag gguuucacua                                                   20


<210>  3372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3372
cuaaaauuuu agcauaagaa                                                   20


<210>  3373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3373
uaugcuaaaa uuuuagugaa                                                   20


<210>  3374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3374
guguacaaaa ugugcccaaa                                                   20


<210>  3375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3375
cacuaauaac ccuuuugggc                                                   20


<210>  3376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3376
uuuucucacu aauaacccuu                                                   20


<210>  3377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3377
gaaguuaucc aaaaguuagu                                                   20


<210>  3378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3378
gaauuagaca aaauuauucu                                                   20


<210>  3379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3379
aauuacagau uugaaaaggu                                                   20


<210>  3380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3380
aaucuguaau uugaacuaac                                                   20


<210>  3381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3381
uaaauaaccu uuucaaaucu                                                   20


<210>  3382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3382
uuacuacauu guuucauaaa                                                   20


<210>  3383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3383
ccccuacuac uuaaugguuc                                                   20


<210>  3384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3384
acauuuuucu ccccuacuac                                                   20


<210>  3385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3385
uuaaaaccug auaaagaauu                                                   20


<210>  3386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3386
uuaucagguu uuaaagaaua                                                   20


<210>  3387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3387
uauuuuauuu uaaucaagac                                                   20


<210>  3388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3388
acaguaaauu aaguagaaaa                                                   20


<210>  3389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3389
acuuaauuua cuguggaagc                                                   20


<210>  3390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3390
uguuuauuaa uuuuugcauc                                                   20


<210>  3391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3391
uuuguuugcu guuuauucuc                                                   20


<210>  3392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3392
cugcuagauu uuguuuaugu                                                   20


<210>  3393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3393
ucaucuuggc caggcugguu                                                   20


<210>  3394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3394
cugccucagc cucccaagua                                                   20


<210>  3395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3395
agcuguucuc ugccucagcc                                                   20


<210>  3396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3396
agauagauga aacaaaggau                                                   20


<210>  3397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3397
uaagcuaccu uugucagguc                                                   20


<210>  3398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3398
ugcggaccug acaaagguag                                                   20


<210>  3399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3399
ugauacguua aguguguuga                                                   20


<210>  3400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3400
gggcucucuc ucccugagua                                                   20


<210>  3401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3401
uacccuuuug cuggcaugcc                                                   20


<210>  3402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3402
uaccagucag ucucuggucu                                                   20


<210>  3403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3403
cucugugcaa acugguuaaa                                                   20


<210>  3404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3404
gacaaaauau uuuauuuaag                                                   20


<210>  3405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3405
ugugacguga guaauucuug                                                   20


<210>  3406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3406
ugggaaauaa agaugauuuu                                                   20


<210>  3407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3407
caagaauuac ucacgucaca                                                   20


<210>  3408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3408
acuaauaauc auuaaaauca                                                   20


<210>  3409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3409
aaauguaaau auguggucca                                                   20


<210>  3410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3410
aauauuaggu uugcuauaug                                                   20


<210>  3411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3411
uuggcuuuug aaaauuguuu                                                   20


<210>  3412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3412
aaagccaaag aagcagcuua                                                   20


<210>  3413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3413
gguugauaaa agcuuuccca                                                   20


<210>  3414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3414
caugcaagag ggcugauguu                                                   20


<210>  3415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3415
cuggguaaag aaagcuuuuu                                                   20


<210>  3416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3416
uuacccagug aaaacacacu                                                   20


<210>  3417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3417
uuguuaaucc acuacaacug                                                   20


<210>  3418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3418
uuaagucaac cuuugaucua                                                   20


<210>  3419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3419
uacccaaggu acccauaaac                                                   20


<210>  3420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3420
gaguaugcuu cuuacccaag                                                   20


<210>  3421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3421
ugguauuauc cucccaauag                                                   20


<210>  3422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3422
cucaaagguu uuaaaugcuu                                                   20


<210>  3423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3423
uuaaagucuu agcacaagug                                                   20


<210>  3424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3424
agaacagacc agguuuuguu                                                   20


<210>  3425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3425
agaaucugug uuuccuuaaa                                                   20


<210>  3426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3426
ccugcaaauc ucuauagcaa                                                   20


<210>  3427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3427
ugacaacaga gguauccacc                                                   20


<210>  3428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3428
ggggguggau accucuguug                                                   20


<210>  3429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3429
cauuaaaucu uuuagccaaa                                                   20


<210>  3430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3430
uuucuucucu ccuagagacc                                                   20


<210>  3431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3431
ucucuccuag agaccaccaa                                                   20


<210>  3432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3432
cuccuagaga ccaccaaguu                                                   20


<210>  3433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3433
ugggaggcag agggaccaau                                                   20


<210>  3434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3434
ucuguaagag augugauccc                                                   20


<210>  3435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3435
ugccucauuu ccucuguaag                                                   20


<210>  3436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3436
cugccuccag acccuauuuu                                                   20


<210>  3437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3437
cgcuucagcu augacaggaa                                                   20


<210>  3438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3438
gcuaugacag gaaauauccu                                                   20


<210>  3439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3439
uugucaauaa aauuucuuca                                                   20


<210>  3440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3440
ucauucuuuc uucacuuugu                                                   20


<210>  3441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3441
uucuuucuuc acuuuguuug                                                   20


<210>  3442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3442
uucuucacuu uguuugugug                                                   20


<210>  3443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3443
ucacuuuguu uguguguuuu                                                   20


<210>  3444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3444
cuuuguuugu guguuuuguc                                                   20


<210>  3445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3445
uuguucaaga ugccaaggac                                                   20


<210>  3446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3446
agaugccaag gaccuggaca                                                   20


<210>  3447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3447
uuaagggguu uagauggugc                                                   20


<210>  3448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3448
gcccucugag gcugugcacc                                                   20


<210>  3449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3449
agaaacagcu cucaacacca                                                   20


<210>  3450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3450
agaagcucag ccuagugucu                                                   20


<210>  3451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3451
uccccuuucg uucugccucg                                                   20


<210>  3452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3452
ccuuucguuc ugccucgaau                                                   20


<210>  3453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3453
uucugccucg aaugucugga                                                   20


<210>  3454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3454
gccucgaaug ucuggagcug                                                   20


<210>  3455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3455
aggcagaacg aaaggggaag                                                   20


<210>  3456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3456
uccucacgcu gacacgaugg                                                   20


<210>  3457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3457
uuggccuuuc auccucacgc                                                   20


<210>  3458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3458
caaauagacu uuuaagucuu                                                   20


<210>  3459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3459
auauccccuc uugaagcuga                                                   20


<210>  3460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3460
agaggggaua uggaagacuu                                                   20


<210>  3461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3461
gcuucaagag gggauaugga                                                   20


<210>  3462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3462
auaagaacaa acaacgcugc                                                   20


<210>  3463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3463
uauggaaauu ucagcuucaa                                                   20


<210>  3464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3464
cuggggcaga ggggagcuuu                                                   20


<210>  3465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3465
aggagucuaa gaagaggggc                                                   20


<210>  3466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3466
uagacuccua gaaagcuccc                                                   20


<210>  3467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3467
gagcccaauc agggggucag                                                   20


<210>  3468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3468
ccacugaccc ccugauuggg                                                   20


<210>  3469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3469
cagccgugcu cucagagauc                                                   20


<210>  3470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3470
ucuaauucuc agccgugcuc                                                   20


<210>  3471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3471
aacagucagc ggcaugguga                                                   20


<210>  3472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3472
aacguuuccu cuaauucuca                                                   20


<210>  3473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3473
ugaggaggug uucccaaauc                                                   20


<210>  3474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3474
cacugcugcc aagccauccc                                                   20


<210>  3475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3475
acugccaugu cccuugccca                                                   20


<210>  3476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3476
uuccacugcc augucccuug                                                   20


<210>  3477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3477
ugguauauug guuucacucu                                                   20


<210>  3478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3478
ggugagaauu cugaugguau                                                   20


<210>  3479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3479
caccugaagu uuuguguuuu                                                   20


<210>  3480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3480
gaugguauug agucaaggua                                                   20


<210>  3481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3481
agcgauucuu uugccucagc                                                   20


<210>  3482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3482
uuugccucag ccuccugagu                                                   20


<210>  3483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3483
uauuguguag aaacccuuag                                                   20


<210>  3484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3484
acacaauaug aagccuuaua                                                   20


<210>  3485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3485
cagcccaccu aaaaagccca                                                   20


<210>  3486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3486
auuauuuuaa auauaaaaau                                                   20


<210>  3487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3487
ccagcucugg gaagccacag                                                   20


<210>  3488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3488
cagagcugga gaaaacuugg                                                   20


<210>  3489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3489
aaagaacaau cuggaagcuu                                                   20


<210>  3490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3490
uuggaacauu uggagguccc                                                   20


<210>  3491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3491
agauuguucu uuggaacauu                                                   20


<210>  3492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3492
acagugauug agaggagaca                                                   20


<210>  3493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3493
ggccugucac cauacuuggg                                                   20


<210>  3494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3494
aguucugaga cucuaugcug                                                   20


<210>  3495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3495
cgaucuguaa aaagucggau                                                   20


<210>  3496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3496
agggcugccc ucccagaaca                                                   20


<210>  3497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3497
gggagggcag cccuggaacu                                                   20


<210>  3498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3498
gcggcugcug uucugggagg                                                   20


<210>  3499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3499
aaggaaggca aagccuugag                                                   20


<210>  3500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3500
uuggaauaca uuuuuugccc                                                   20


<210>  3501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3501
aauccauuuc uuacccacag                                                   20


<210>  3502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3502
uacccacaga cugucauuuc                                                   20


<210>  3503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3503
uuuuuuagag cauaaacuca                                                   20


<210>  3504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3504
cuccaugaau aggcugucuc                                                   20


<210>  3505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3505
uggagagaag uagcugcguc                                                   20


<210>  3506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3506
gugccuggga gacagccuau                                                   20


<210>  3507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3507
aggaaccagc agggccuuuc                                                   20


<210>  3508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3508
uggaauucug ugccugggag                                                   20


<210>  3509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3509
agguugguuu caagggaaga                                                   20


<210>  3510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3510
agggaagagu gugucccuug                                                   20


<210>  3511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3511
cuugaaacca accuugaaag                                                   20


<210>  3512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3512
ggcucuugga gcuggcucca                                                   20


<210>  3513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3513
uguugggucc agaguugcau                                                   20


<210>  3514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3514
gugaucuugg uuauuugaau                                                   20


<210>  3515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3515
aauaaccaag aucacagaac                                                   20


<210>  3516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3516
cugagccuca guuuccucaa                                                   20


<210>  3517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3517
ucaauccuua gguggaaaua                                                   20


<210>  3518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3518
accuaaggau ugaggaaacu                                                   20


<210>  3519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3519
uaccuuaucc agaaucaguu                                                   20


<210>  3520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3520
ucuacagaau uccucuugcc                                                   20


<210>  3521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3521
uucuaacauc guagcacaaa                                                   20


<210>  3522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3522
aacaucguag cacaaaagua                                                   20


<210>  3523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3523
uuacauacua cuuuugugcu                                                   20


<210>  3524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3524
aauaaaacuu uuuagaggcu                                                   20


<210>  3525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3525
gauuugcuac gugacuucag                                                   20


<210>  3526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3526
ggcaacucac uuuccuuuuc                                                   20


<210>  3527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3527
uuuucugggc cuauaaauca                                                   20


<210>  3528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3528
gggccuauaa aucaaagcag                                                   20


<210>  3529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3529
uuguuggggg ugcuguccug                                                   20


<210>  3530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3530
aguagcaacc uacaaugcac                                                   20


<210>  3531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3531
cuacccgcuu gaggcagaag                                                   20


<210>  3532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3532
gccucaagcg gguagggaag                                                   20


<210>  3533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3533
ucugagucgc ccagccgagc                                                   20


<210>  3534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3534
gagucgccca gccgagccag                                                   20


<210>  3535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3535
cuggcucggc ugggcgacuc                                                   20


<210>  3536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3536
gagugugcuu guuuagagag                                                   20


<210>  3537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3537
caaauagagc cauuguguca                                                   20


<210>  3538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3538
agggccugag cuuccagccu                                                   20


<210>  3539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3539
agccuggccc agggauucag                                                   20


<210>  3540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3540
gguugaagca gggcccgagg                                                   20


<210>  3541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3541
accugaaucc cugggccagg                                                   20


<210>  3542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3542
acccaccugg ggcagggcca                                                   20


<210>  3543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3543
cccuccuuua cgggcacuca                                                   20


<210>  3544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3544
uaagcagcua ggauuacaag                                                   20


<210>  3545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3545
ccugccucag cuuccuaagc                                                   20


<210>  3546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3546
agugauucuc cugccucagc                                                   20


<210>  3547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3547
uuauuauuau aggucaggga                                                   20


<210>  3548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3548
auugugcagu gguuguuuuc                                                   20


<210>  3549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3549
uccaguggac auugaccuuc                                                   20


<210>  3550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3550
ccaccccaac cgucccccag                                                   20


<210>  3551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3551
auguggaucc cccacagcag                                                   20


<210>  3552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3552
cacauggggu cggggucauu                                                   20


<210>  3553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3553
cagcuuaacu ccucccgggc                                                   20


<210>  3554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3554
aaaaacaaaa cacacaagca                                                   20


<210>  3555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3555
cagaagcagg uuucuccucu                                                   20


<210>  3556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3556
gggaaaaaaa auucaaaaaa                                                   20


<210>  3557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3557
ccucuugaca gccucuccua                                                   20


<210>  3558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3558
uguagggagc aaaaaauucu                                                   20


<210>  3559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3559
caggaagaga acugcaggua                                                   20


<210>  3560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3560
ugugaaucug uccagggggc                                                   20


<210>  3561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3561
cuuccuguga aucuguccag                                                   20


<210>  3562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3562
aaagggcaug uuaccaaaug                                                   20


<210>  3563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3563
ccuacugcau cuugaacauu                                                   20


<210>  3564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3564
agaugcagua ggugaaacuu                                                   20


<210>  3565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3565
aaguggggcu ugcccagcca                                                   20


<210>  3566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3566
gugaucacaa aucccuucca                                                   20


<210>  3567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3567
agucccugua ccuguaacuu                                                   20


<210>  3568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3568
aggcugucca uuguaccuuc                                                   20


<210>  3569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3569
gccuccuaca ucugugugau                                                   20


<210>  3570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3570
cuguguccag augugugacg                                                   20


<210>  3571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3571
gguggccggg acgcucugcu                                                   20


<210>  3572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3572
cuugguggag cgaaggggau                                                   20


<210>  3573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3573
cuccaccaag cgaagcagag                                                   20


<210>  3574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3574
ucugcugcgg ugcagguggc                                                   20


<210>  3575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3575
cugaggacuc cacagugagg                                                   20


<210>  3576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3576
ccaugucuuu aaaagccaug                                                   20


<210>  3577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3577
uggguuucuc caugucuuua                                                   20


<210>  3578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3578
uggaggaggu ggcagcugag                                                   20


<210>  3579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3579
gucccauacc aagcugagcu                                                   20


<210>  3580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3580
ucauuugaaa ugaaaaggac                                                   20


<210>  3581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3581
aaugaggaag uuaaagcuua                                                   20


<210>  3582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3582
uuucaaauga ggaaguuaaa                                                   20


<210>  3583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3583
ugcucccagg caccucaguc                                                   20


<210>  3584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3584
gaccuagagu uacccacagc                                                   20


<210>  3585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3585
gagaacugac ggugccacag                                                   20


<210>  3586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3586
cugaauagca cccagcauac                                                   20


<210>  3587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3587
ugagggcagg gauuuugucu                                                   20


<210>  3588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3588
gucaccuuag ugaccagcug                                                   20


<210>  3589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3589
caucugcccu cuaagcaaac                                                   20


<210>  3590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3590
ugcugugggc agaacucacc                                                   20


<210>  3591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3591
gcccacagca ggaaguuugc                                                   20


<210>  3592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3592
ccucauccgu aaaaugagga                                                   20


<210>  3593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3593
gagaaggugu aaaugugguc                                                   20


<210>  3594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3594
cugaaccucu uucuccucau                                                   20


<210>  3595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3595
aggaggaaua uucucugucc                                                   20


<210>  3596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3596
uccuggaagg aggcaaguug                                                   20


<210>  3597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3597
cuguccugcc cucaucugca                                                   20


<210>  3598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3598
aauccaggau cccaucaauc                                                   20


<210>  3599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3599
guuccugcag gacccccaaa                                                   20


<210>  3600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3600
ugcaggaccc ccaaaguggu                                                   20


<210>  3601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3601
ucguaagugg ggaugucaac                                                   20


<210>  3602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3602
caguggccga ggggccccca                                                   20


<210>  3603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3603
uccguagggu augcaggugg                                                   20


<210>  3604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3604
gcggagacga caccgagugc                                                   20


<210>  3605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3605
ucccaggcuc aagagauccu                                                   20


<210>  3606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3606
ucucucugcc uuagccuccu                                                   20


<210>  3607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3607
cauuuuacag augaggaggc                                                   20


<210>  3608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3608
cucaaagagc ugauuuguga                                                   20


<210>  3609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3609
auaaugaaag cccaggccag                                                   20


<210>  3610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3610
uuauugaaag ugagcuggga                                                   20


<210>  3611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3611
caccuacacc uccaggcucc                                                   20


<210>  3612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3612
gugccugccc aguaaagugg                                                   20


<210>  3613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3613
aguuaggcca cagaugagug                                                   20


<210>  3614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3614
ugaugcuggu gaccuugagc                                                   20


<210>  3615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3615
ggacuuugcc caaaugucgc                                                   20


<210>  3616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3616
ucaggacuuu gcccaaaugu                                                   20


<210>  3617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3617
uguagcugca uggcucccuc                                                   20


<210>  3618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3618
uccuguagcu gcauggcucc                                                   20


<210>  3619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3619
gccuggagug cuguucuucc                                                   20


<210>  3620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3620
uucugccugg agugcuguuc                                                   20


<210>  3621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3621
aggaacagca uggggccagg                                                   20


<210>  3622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3622
uggaacacgc augcauccca                                                   20


<210>  3623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3623
gguuagcaag ccccgucacc                                                   20


<210>  3624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3624
uccccaggcc ugccccuccc                                                   20


<210>  3625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3625
ccugccccgu cagaacucca                                                   20


<210>  3626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3626
cucccugccu cgggguguca                                                   20


<210>  3627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3627
ggauccuugc gagcgggcuc                                                   20


<210>  3628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3628
ucguccagca gagggcgcgc                                                   20


<210>  3629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3629
ucgccuguga aaugcgggcg                                                   20


<210>  3630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3630
caggcgagga aaccgagccu                                                   20


<210>  3631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3631
cccgggguca gcggcugggc                                                   20


<210>  3632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3632
cacgcuaugc accacccagu                                                   20


<210>  3633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3633
cauucacacg cuaugcacca                                                   20


<210>  3634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3634
uccauccccu ucacauucac                                                   20


<210>  3635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3635
cauuuuacag aggaggaaac                                                   20


<210>  3636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3636
uccucuguaa aaugggaaua                                                   20


<210>  3637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3637
gcagcugaga gcuguuagaa                                                   20


<210>  3638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3638
agagcuggaa ggugugaggc                                                   20


<210>  3639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3639
agcucuagaa aacaggguac                                                   20


<210>  3640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3640
cacacacacu ccaggccagc                                                   20


<210>  3641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3641
cucugggccc ggcuggccug                                                   20


<210>  3642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3642
acggacccac acccagccac                                                   20


<210>  3643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3643
cgucagccau ggcugccugg                                                   20


<210>  3644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3644
ggaucggcuu cauugugcug                                                   20


<210>  3645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3645
uugugcuggg gcuuuuccug                                                   20


<210>  3646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3646
ugcuggcccu cgguacguuc                                                   20


<210>  3647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3647
ucaugagcca ugaucggccc                                                   20


<210>  3648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3648
augccauggg cagcgucaug                                                   20


<210>  3649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3649
caucacuaaa uuacacauaa                                                   20


<210>  3650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3650
aguucaaguc cuguuccaaa                                                   20


<210>  3651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3651
aguccuguuc caaacucucu                                                   20


<210>  3652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3652
aaacucucua ugaccuuugu                                                   20


<210>  3653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3653
auuccacaga gcuguuggga                                                   20


<210>  3654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3654
caacuccugg cauuuccauu                                                   20


<210>  3655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3655
augccuagag aggcugggug                                                   20


<210>  3656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3656
aaggucacac agcuggucag                                                   20


<210>  3657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3657
cccugggucu guaccugacc                                                   20


<210>  3658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3658
cuccuuuucu cccugggucu                                                   20


<210>  3659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3659
guucagugcu ggagcggucu                                                   20


<210>  3660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3660
gugcuggagc ggucugggcu                                                   20


<210>  3661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3661
uugagcagag gucacuggga                                                   20


<210>  3662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3662
cccagugacc ucugcucaag                                                   20


<210>  3663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3663
cuccuccccu ccccuccccu                                                   20


<210>  3664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3664
uggguucacg ugcuguggag                                                   20


<210>  3665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3665
cgugcugugg aggcagcgug                                                   20


<210>  3666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3666
aaucccugcu ccuucauguc                                                   20


<210>  3667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3667
ugucccacuu cugugaccuu                                                   20


<210>  3668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3668
gugaccuugg cagaaagagu                                                   20


<210>  3669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3669
gccaagguca cagaaguggg                                                   20


<210>  3670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3670
cugugaagcc uguuuccucc                                                   20


<210>  3671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3671
ccaagcagag aagaugggga                                                   20


<210>  3672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3672
cugcuuggug aacucuuauc                                                   20


<210>  3673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3673
ccaucuucuc ugcuugguga                                                   20


<210>  3674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3674
aggcagaaga guagcaugau                                                   20


<210>  3675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3675
ucucuggucu uggugagagc                                                   20


<210>  3676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3676
cuggucuugg ugagagcuga                                                   20


<210>  3677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3677
agaugacugu cagcucucac                                                   20


<210>  3678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3678
gcauuauucc agaugacugu                                                   20


<210>  3679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3679
aacacaaagc uguaggaacu                                                   20


<210>  3680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3680
gacacaugcu acaacaucac                                                   20


<210>  3681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3681
auccuuaagg cugaauagua                                                   20


<210>  3682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3682
gccuuaagga uggaacuucu                                                   20


<210>  3683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3683
ucauauggau agacuauauu                                                   20


<210>  3684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3684
ucccugcuga cucugacuuu                                                   20


<210>  3685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3685
aggcauccuc uccccaaagg                                                   20


<210>  3686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3686
ccagcaggcc cauggccuuu                                                   20


<210>  3687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3687
ucucggcagc aagcccauuc                                                   20


<210>  3688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3688
ugcccucccu cucacucucc                                                   20


<210>  3689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3689
cacuuacuga gaauguauua                                                   20


<210>  3690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3690
cauuguacag augaggaaac                                                   20


<210>  3691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3691
ucaucuguac aaugggaaua                                                   20


<210>  3692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3692
gugaauacaa gaucuccaug                                                   20


<210>  3693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3693
ccgaaacacu gucucguccc                                                   20


<210>  3694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3694
uggagaucuu guauucaccg                                                   20


<210>  3695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3695
uuguaugauu uguuucaugg                                                   20


<210>  3696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3696
uagcuguaua aagagccuaa                                                   20


<210>  3697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3697
cugagccuca aucuuccuag                                                   20


<210>  3698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3698
cucucccacu ccagccccag                                                   20


<210>  3699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3699
ucccacagcc uuacauaggg                                                   20


<210>  3700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3700
gccacaucca gaugaaaguc                                                   20


<210>  3701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3701
ucuggaugug gcugaaguca                                                   20


<210>  3702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3702
gcugccccau cucaggggcc                                                   20


<210>  3703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3703
cagcuucggc ugccccaucu                                                   20


<210>  3704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3704
ccuccaucac ugguucccag                                                   20


<210>  3705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3705
ggccuggaug gaggcugccg                                                   20


<210>  3706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3706
cucucgucug agcccuugug                                                   20


<210>  3707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3707
ccuucacucu cgucugagcc                                                   20


<210>  3708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3708
gcccaguuca aggguuaaaa                                                   20


<210>  3709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3709
aaccccagcu ccugugcugu                                                   20


<210>  3710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3710
uuacuuuccc uagccucagu                                                   20


<210>  3711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3711
cuagccucag uuuccccaca                                                   20


<210>  3712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3712
ccacacaggg augaucauuc                                                   20


<210>  3713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3713
uacuacccag gaauguugag                                                   20


<210>  3714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3714
uggguaguag gaaugaucau                                                   20


<210>  3715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3715
gagacaucaa gggccuacug                                                   20


<210>  3716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3716
aauuuggguc ugcugcugac                                                   20


<210>  3717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3717
caaacagaca gggaugggag                                                   20


<210>  3718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3718
uccauguacu uauucauucc                                                   20


<210>  3719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3719
uuccauccac auuacugagc                                                   20


<210>  3720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3720
auccacauua cugagcacca                                                   20


<210>  3721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3721
ugcccagccu ucacuggaau                                                   20


<210>  3722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3722
cuggaaucua ccccugagga                                                   20


<210>  3723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3723
agugaaggcu gggcaggaag                                                   20


<210>  3724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3724
ccucuguugc ucauaggccc                                                   20


<210>  3725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3725
ggguucuccu cuguugcuca                                                   20


<210>  3726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3726
ccaauuauuc aggguucucc                                                   20


<210>  3727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3727
gauaauagca uaguaauagc                                                   20


<210>  3728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3728
ugagcaccuu cuaugugcca                                                   20


<210>  3729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3729
augugccagg cacugugcaa                                                   20


<210>  3730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3730
uagguuuaca gcagauaaua                                                   20


<210>  3731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3731
uucuuagguu uacagcagau                                                   20


<210>  3732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3732
cuccugcagu ucuuucuuag                                                   20


<210>  3733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3733
guuauuggga agaaacugag                                                   20


<210>  3734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3734
caauaacaga auucacuccu                                                   20


<210>  3735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3735
ucccaauaac agaauucacu                                                   20


<210>  3736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3736
cgggccucag uuucuuccca                                                   20


<210>  3737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3737
agccgcuagc ugcaagaccu                                                   20


<210>  3738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3738
gacucagaga uacccuugcc                                                   20


<210>  3739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3739
uuccaagaug accuggacau                                                   20


<210>  3740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3740
aagaugaccu ggacauggac                                                   20


<210>  3741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3741
cuggagucca uguccagguc                                                   20


<210>  3742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3742
ucccugucau guggagaugc                                                   20


<210>  3743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3743
uguugugggg aacaagcuuc                                                   20


<210>  3744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3744
aagacuuugc ccugauugau                                                   20


<210>  3745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3745
cacugcugcc ccucuugggg                                                   20


<210>  3746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3746
ccuccaccuu uguccuuggg                                                   20


<210>  3747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3747
gacacaggug gggaggaacc                                                   20


<210>  3748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3748
uccccaccug uguccgaagc                                                   20


<210>  3749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3749
cagguuccuc cccaccugug                                                   20


<210>  3750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3750
uucucagguu ccuccccacc                                                   20


<210>  3751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3751
ucuuccuucu cagguuccuc                                                   20


<210>  3752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3752
agucuggaac ugcugcugac                                                   20


<210>  3753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3753
agacuagaag cuacggagca                                                   20


<210>  3754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3754
aauaguuagu ggucuuuggc                                                   20


<210>  3755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3755
aagguuggcc aaagaccacu                                                   20


<210>  3756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3756
gcugcugcaa accucaacaa                                                   20


<210>  3757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3757
cccaaagcug accucugaga                                                   20


<210>  3758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3758
ucucagaggu cagcuuuggg                                                   20


<210>  3759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3759
uuggugcucc cucugggccc                                                   20


<210>  3760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3760
caaaggauca ggggcccaga                                                   20


<210>  3761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3761
cugcagcugc caggauccug                                                   20


<210>  3762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3762
ccugggcuau gggguucugg                                                   20


<210>  3763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3763
ggguugaggc ugggguuccc                                                   20


<210>  3764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3764
cggccuaggg aagggcuucc                                                   20


<210>  3765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3765
cuaggccggg aaccccagcc                                                   20


<210>  3766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3766
ggguugaggc cggggguccu                                                   20


<210>  3767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3767
cuaggccagg acccccggcc                                                   20


<210>  3768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3768
cagggccaug accuuguaac                                                   20


<210>  3769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3769
uuuucuuucu gggucauuuc                                                   20


<210>  3770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3770
uucuggguca uuucugccuc                                                   20


<210>  3771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3771
gggucauuuc ugccucugca                                                   20


<210>  3772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3772
gccucugcag ugaaggaugc                                                   20


<210>  3773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3773
cugcagaggc agaaaugacc                                                   20


<210>  3774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3774
uggucacagc ugagucuucg                                                   20


<210>  3775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3775
gaugagguga gggguagcau                                                   20


<210>  3776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3776
aacguggguu guaggcugcc                                                   20


<210>  3777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3777
acauuuaaag gggucaucuu                                                   20


<210>  3778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3778
uucaccugca aauucuuuuc                                                   20


<210>  3779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3779
ccugcaaauu cuuuucuuua                                                   20


<210>  3780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3780
uuucuuuaaa accaccccuu                                                   20


<210>  3781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3781
uuaaaaccac cccuucccuc                                                   20


<210>  3782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3782
cucggggcag gauacgugag                                                   20


<210>  3783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3783
ggaaguaagc ccucacugca                                                   20


<210>  3784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3784
ggaagagggc cucuggugcc                                                   20


<210>  3785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3785
gcaccacaca gcacacccca                                                   20


<210>  3786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3786
ccacaccccu gaaccacaac                                                   20


<210>  3787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3787
gggguguggg gaaucacucc                                                   20


<210>  3788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3788
ugcuggcagg cccagcaacc                                                   20


<210>  3789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3789
agaguuagca ucugcagggg                                                   20


<210>  3790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3790
ugggcagauc aggugugugg                                                   20


<210>  3791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3791
cgcucgaaga uaccucauuu                                                   20


<210>  3792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3792
agcgugaaag gggccuccua                                                   20


<210>  3793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3793
caugugcaaa ugacagauga                                                   20


<210>  3794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3794
ucugucauuu gcacaugaga                                                   20


<210>  3795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3795
aagauaugcg cacuucaucu                                                   20


<210>  3796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3796
aagauuccaa gauaugcgca                                                   20


<210>  3797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3797
ucuugcagua agggggaaug                                                   20


<210>  3798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3798
ugcaguaagg gggaaugaac                                                   20


<210>  3799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3799
cccuuacugc aagaagaaac                                                   20


<210>  3800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3800
uucccccuua cugcaagaag                                                   20


<210>  3801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3801
cugugguguu cauucccccu                                                   20


<210>  3802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3802
gagacucccc cugguucgcu                                                   20


<210>  3803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3803
aauaccucuu ucagagacuc                                                   20


<210>  3804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3804
agagucccuc caaccugaca                                                   20


<210>  3805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3805
acccucugga gagggaaagg                                                   20


<210>  3806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3806
cucuccagag gguggaaacu                                                   20


<210>  3807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3807
cugccccugg gcccccugcc                                                   20


<210>  3808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3808
cuguaaaauu gggugagggu                                                   20


<210>  3809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3809
ggagccuggg auuuauaaca                                                   20


<210>  3810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3810
gauucuggag ccugggauuu                                                   20


<210>  3811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3811
gccucagcca guuccuugcu                                                   20


<210>  3812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3812
acugagcauc ucccugugcu                                                   20


<210>  3813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3813
augacugccu auugcccaca                                                   20


<210>  3814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3814
cccaguaccu agcacagggg                                                   20


<210>  3815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3815
cccaagacaa gcauggguca                                                   20


<210>  3816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3816
uuugugggau cacagauauu                                                   20


<210>  3817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3817
uuuguuucuu uugugggauc                                                   20


<210>  3818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3818
ccugagguua accauguuuu                                                   20


<210>  3819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3819
uguuuuaauu ugcauucccc                                                   20


<210>  3820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3820
cccauaacac uggcaucauu                                                   20


<210>  3821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3821
gccagcucca ccuauuauua                                                   20


<210>  3822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3822
uccacauucu gccagcucca                                                   20


<210>  3823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3823
gacguugcug augugaaugg                                                   20


<210>  3824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3824
cuuaauuaua cauuacaaaa                                                   20


<210>  3825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3825
cuccuuccuu gauuuuguuu                                                   20


<210>  3826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3826
uugauuuugu uugugaguga                                                   20


<210>  3827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3827
gucaaugaau ugugauuggu                                                   20


<210>  3828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3828
uugacugaaa guggggaugu                                                   20


<210>  3829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3829
cugcugcugg aggugguccu                                                   20


<210>  3830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3830
ggccaguaag accuaaagag                                                   20


<210>  3831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3831
cuuuaggucu uacuggccag                                                   20


<210>  3832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3832
gaaguuuuug cuuuuauaau                                                   20


<210>  3833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3833
gaaagugacc cccaacagau                                                   20


<210>  3834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3834
gcauuuuuau uauaaaagca                                                   20


<210>  3835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3835
augccugcaa aggcagucac                                                   20


<210>  3836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3836
cucaugacug caagacagcu                                                   20


<210>  3837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3837
aagagauuca cagagaugcu                                                   20


<210>  3838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3838
cagagaugcu ggaccuaaca                                                   20


<210>  3839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3839
acaauguuag guccagcauc                                                   20


<210>  3840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3840
cugguucaac aauguuaggu                                                   20


<210>  3841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3841
gaaagcugag ugggaccauc                                                   20


<210>  3842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3842
gaaaauaugu auuuauagcc                                                   20


<210>  3843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3843
cacaacaaau ccaggucauc                                                   20


<210>  3844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3844
ugcagaugac cuggauuugu                                                   20


<210>  3845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3845
ucaaggucau uuucaugcag                                                   20


<210>  3846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3846
ucuccuccaa uuuuccucaa                                                   20


<210>  3847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3847
ucccuggcug agauggcuga                                                   20


<210>  3848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3848
cugcaccauu aacacccuga                                                   20


<210>  3849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3849
aucaccuccu cgucagggug                                                   20


<210>  3850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3850
ggggccccua gcccucaccc                                                   20


<210>  3851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3851
gcugcuucgg gggccccuag                                                   20


<210>  3852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3852
ucccgguccc caccuccacu                                                   20


<210>  3853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3853
uuccuuucac ccuggaccuc                                                   20


<210>  3854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3854
uuucacccug gaccucagag                                                   20


<210>  3855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3855
cccuggaccu cagagcacug                                                   20


<210>  3856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3856
ucccccucca ugcuugccuc                                                   20


<210>  3857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3857
aaagcaguuu uagaugugcu                                                   20


<210>  3858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3858
gcugaugagu gaacugaggc                                                   20


<210>  3859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3859
cucaucagca gaacaguggc                                                   20


<210>  3860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3860
gagccucagu ucacucauca                                                   20


<210>  3861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3861
cggugugacc cugggcaaca                                                   20


<210>  3862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3862
aaucccagcu cugcuacaaa                                                   20


<210>  3863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3863
ggaucuccgc cugggucgug                                                   20


<210>  3864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3864
gccuccacaa cauccccuuc                                                   20


<210>  3865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3865
cccuuucuuc ccuccucaug                                                   20


<210>  3866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3866
ucccuccuca ugauagccac                                                   20


<210>  3867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3867
cuccucauga uagccacugu                                                   20


<210>  3868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3868
cuuuggucug gagagagugg                                                   20


<210>  3869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3869
gcuggaccag gagcuccuac                                                   20


<210>  3870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3870
cuuugccaag ggaguccucu                                                   20


<210>  3871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3871
cccucuucuc uuugccaagg                                                   20


<210>  3872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3872
gcccuauguu cccccucuuc                                                   20


<210>  3873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3873
gggagugcug ccuggaggag                                                   20


<210>  3874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3874
caugacaccc accccaaggg                                                   20


<210>  3875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3875
uugccugaua auucucauga                                                   20


<210>  3876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3876
cagcauucuu ugccugauaa                                                   20


<210>  3877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3877
aggaggaagg cauagcauga                                                   20


<210>  3878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3878
uccuggaaug cccuucccag                                                   20


<210>  3879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3879
gggaguaaau cugugguucc                                                   20


<210>  3880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3880
cacacuuagg gcugcuuugg                                                   20


<210>  3881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3881
uaaacuccuc aggagauacc                                                   20


<210>  3882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3882
ugggcccagu uccuggagau                                                   20


<210>  3883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3883
uggagauucu gggccaggca                                                   20


<210>  3884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3884
gggccaggca gaggaaucug                                                   20


<210>  3885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3885
ucugccuggc ccagaaucuc                                                   20


<210>  3886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3886
caaagcggga ggguaggagg                                                   20


<210>  3887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3887
accacucuga ugcagguggc                                                   20


<210>  3888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3888
ccaagcaugg cccaggggcc                                                   20


<210>  3889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3889
uacagcgcac uccaccucug                                                   20


<210>  3890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3890
gcagcucuuc cuacagcgca                                                   20


<210>  3891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3891
auaggcuugu ccaagagggu                                                   20


<210>  3892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3892
cuuuucauca uucucuagug                                                   20


<210>  3893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3893
ucauucucua gugcucuuau                                                   20


<210>  3894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3894
cuagugcucu uaucaccaac                                                   20


<210>  3895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3895
gccuauaagu uggugauaag                                                   20


<210>  3896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3896
cucaacuaug agggcugcau                                                   20


<210>  3897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3897
caugcagccc ucauaguuga                                                   20


<210>  3898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3898
cugcuguacc ccaaugucug                                                   20


<210>  3899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3899
auguuacaga cauuggggua                                                   20


<210>  3900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3900
guuugcauuu uuuuucuuuu                                                   20


<210>  3901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3901
uuuugagaug gagucucccu                                                   20


<210>  3902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3902
uccuggguga caagagggag                                                   20


<210>  3903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3903
agcgauucuc ugccucagcc                                                   20


<210>  3904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3904
cugccucagc cuaccgagua                                                   20


<210>  3905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3905
ccauguuggu caggcugguc                                                   20


<210>  3906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3906
agaccagccu gaccaacaug                                                   20


<210>  3907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3907
ggugauccac ccgccucagc                                                   20


<210>  3908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3908
acccuaaaaa aacaaaaugc                                                   20


<210>  3909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3909
ugccagccuc ucagcacgcu                                                   20


<210>  3910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3910
cugacauguc ugccuggcuc                                                   20


<210>  3911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3911
cuuuaagccg gcagggagug                                                   20


<210>  3912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3912
uggcaccugc cacaggcagc                                                   20


<210>  3913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3913
ccaugaagug gcagacaagg                                                   20


<210>  3914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3914
uggagaaaag gaggccacug                                                   20


<210>  3915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3915
ugggaagaga ggggaggaga                                                   20


<210>  3916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3916
caggaagccc cuugucugcc                                                   20


<210>  3917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3917
ugagcaggug gagaggaaag                                                   20


<210>  3918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3918
ucuccaccug cucaagaaug                                                   20


<210>  3919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3919
gaaucuccca gaguccccua                                                   20


<210>  3920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3920
gaacaaaaga gggucaugac                                                   20


<210>  3921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3921
uaccaccauu auaacuggac                                                   20


<210>  3922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3922
uggagguggc agcucgggau                                                   20


<210>  3923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3923
gugcccaucu gacugaguuc                                                   20


<210>  3924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3924
cgcagcaccu agccuguccc                                                   20


<210>  3925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3925
gugagacuug gcuccucuug                                                   20


<210>  3926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3926
gcucaggggu gagagcaggu                                                   20


<210>  3927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3927
ggccacucug gagcagcagc                                                   20


<210>  3928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3928
ugggagaggc cugguucucu                                                   20


<210>  3929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3929
cugggccugu cccucucucc                                                   20


<210>  3930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3930
uuccuuccuc ccuuccugaa                                                   20


<210>  3931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3931
uuccucccuu ccugaaacug                                                   20


<210>  3932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3932
ucccuuccug aaacugcguc                                                   20


<210>  3933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3933
ugaaacugcg uccuccaaau                                                   20


<210>  3934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3934
ggaagggagg aaggaaggaa                                                   20


<210>  3935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3935
acagccucug gcagcguuuc                                                   20


<210>  3936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3936
gucccuuucu ggccuugacu                                                   20


<210>  3937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3937
ggccuugacu ggaaggcccc                                                   20


<210>  3938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3938
agucaaggcc agaaagggac                                                   20


<210>  3939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3939
ccccgccuga gagggguagg                                                   20


<210>  3940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3940
cuccuccaua aacgcaguca                                                   20


<210>  3941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3941
ggcaacgaca gaccacauac                                                   20


<210>  3942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3942
auaagauuac aacagagcug                                                   20


<210>  3943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3943
cagcucuguu guaaucuuau                                                   20


<210>  3944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3944
ggccaucugg gcguauacgu                                                   20


<210>  3945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3945
guuacuucag gccaucuggg                                                   20


<210>  3946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3946
ucaguuacuu caggccaucu                                                   20


<210>  3947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3947
uuugugauuc uucaguuacu                                                   20


<210>  3948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3948
cuucuuuugu gauucuucag                                                   20


<210>  3949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3949
accacaaaag aaguguaaau                                                   20


<210>  3950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3950
uuuguggugg aaugucauca                                                   20


<210>  3951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3951
caagguaaug ucaucaguua                                                   20


<210>  3952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3952
ugguucaucc uggcucaaaa                                                   20


<210>  3953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3953
uccuggcuca aaaagcaccu                                                   20


<210>  3954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3954
cuggcgggua ggaguggggg                                                   20


<210>  3955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3955
uuuaccuacc caaauccuau                                                   20


<210>  3956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3956
cugacucucu uuuuggacuc                                                   20


<210>  3957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3957
ccugggugca ggcgggcuga                                                   20


<210>  3958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3958
cacggaugca cauguaauuu                                                   20


<210>  3959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3959
ccaaauuaca ugugcauccg                                                   20


<210>  3960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3960
cauggagcaa agagcaggag                                                   20


<210>  3961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3961
ugggcugguc ggucugagga                                                   20


<210>  3962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3962
aguccgguaa gcugccucuu                                                   20


<210>  3963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3963
ccaaccuccc ucacuauccc                                                   20


<210>  3964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3964
ccuuucaauc uuggcgccac                                                   20


<210>  3965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3965
aucuuggcgc cacacuucaa                                                   20


<210>  3966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3966
aucucucccu ucucuuaauu                                                   20


<210>  3967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3967
cuuaauuuca auuucuuuca                                                   20


<210>  3968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3968
auuucuuuca uuuuuuggua                                                   20


<210>  3969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3969
uucauuuuuu gguagagaca                                                   20


<210>  3970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3970
uuuuuuggua gagacaaaag                                                   20


<210>  3971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3971
uggauaaaac augucucuuu                                                   20


<210>  3972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3972
caguccguga ccggcaccgg                                                   20


<210>  3973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3973
cuugguguuu aaucauugca                                                   20


<210>  3974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3974
agggugucag accacgcagg                                                   20


<210>  3975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3975
cccuuagcgg caagucccgc                                                   20


<210>  3976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3976
uagggggcaa ggacccccca                                                   20


<210>  3977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3977
gcaccccaac cucuuaucuc                                                   20


<210>  3978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3978
gcacccugac cucuuaucuc                                                   20


<210>  3979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3979
gugucccaac ccccucucug                                                   20


<210>  3980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3980
ggagggcaag aaccccacuc                                                   20


<210>  3981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3981
ugcccuccag aaaagcagag                                                   20


<210>  3982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3982
caggguuugc cuccuucacu                                                   20


<210>  3983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3983
cuaugggcaa ccuuccaccc                                                   20


<210>  3984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3984
acccuccauu ccuccuucuu                                                   20


<210>  3985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3985
uccuucuucu ccuuuagccu                                                   20


<210>  3986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3986
ucuccuuuag ccuguguccu                                                   20


<210>  3987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3987
ccuuuagccu guguccuuaa                                                   20


<210>  3988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3988
uaaggacaca ggcuaaagga                                                   20


<210>  3989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3989
acucacaccu gaccuaaaac                                                   20


<210>  3990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3990
ucugcaacac cacuuggccc                                                   20


<210>  3991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3991
gcaacaccac uuggccccaa                                                   20


<210>  3992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3992
ggccauuuag ggccauuguc                                                   20


<210>  3993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3993
gcauccuaca agaccuaaau                                                   20


<210>  3994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3994
acaaaaauua uuuaggucuu                                                   20


<210>  3995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3995
cacuucguuc ccucccuagc                                                   20


<210>  3996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3996
uucccucccu agccucuguu                                                   20


<210>  3997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3997
cucccuagcc ucuguuccca                                                   20


<210>  3998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3998
caaugcaauu ccucccagau                                                   20


<210>  3999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  3999
ucccagaucc uccuucuuuc                                                   20


<210>  4000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4000
uucccucccg ccuguccccu                                                   20


<210>  4001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4001
cucccgccug uccccucagu                                                   20


<210>  4002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4002
agucuuccuu uucuacagac                                                   20


<210>  4003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4003
uuuucuacag acccaucuga                                                   20


<210>  4004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4004
acagacccau cugaccuuuc                                                   20


<210>  4005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4005
ccuccucccc aggcugcuca                                                   20


<210>  4006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4006
uccucagccu ccgcuccucc                                                   20


<210>  4007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4007
ucagccuccg cuccuccacc                                                   20


<210>  4008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4008
uuccgugacu ggcccucccc                                                   20


<210>  4009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4009
gugacuggcc cucccccacc                                                   20


<210>  4010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4010
uuaucccaaa ucagauagca                                                   20


<210>  4011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4011
ucaaauauaa aaauccagcc                                                   20


<210>  4012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4012
ugacucguuu ggcagcaacc                                                   20


<210>  4013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4013
caauacucau uuuauuaccc                                                   20


<210>  4014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4014
agcccucaaa ccucacaaca                                                   20


<210>  4015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4015
aggugugcaa uaauagaaaa                                                   20


<210>  4016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4016
auuauugcac accuugaagg                                                   20


<210>  4017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4017
uugccuccac ugugagacaa                                                   20


<210>  4018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4018
ugugugcugg agauguggcu                                                   20


<210>  4019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4019
aaacgccuga accacagcgg                                                   20


<210>  4020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4020
ggcguuugga aguucuugug                                                   20


<210>  4021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4021
uccagaaccu ccucccccag                                                   20


<210>  4022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4022
ggaggaacgc cuggccgcug                                                   20


<210>  4023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4023
ggcacuugua gcaaacuccu                                                   20


<210>  4024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4024
uuggcccagu ggccagauuu                                                   20


<210>  4025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4025
ucuuaagccg cgucccaucu                                                   20


<210>  4026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4026
gugggguccc acacagaugg                                                   20


<210>  4027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4027
acucaccugg cagccacucc                                                   20


<210>  4028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4028
aggggcucug ggaguggcug                                                   20


<210>  4029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4029
cagaucuucu cggcuuagcg                                                   20


<210>  4030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4030
cggcuuagcg gcugaagacu                                                   20


<210>  4031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4031
gccgcuaagc cgagaagauc                                                   20


<210>  4032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4032
gaggcgaucg ggcaguguca                                                   20


<210>  4033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4033
acugugagag uuacccaaag                                                   20


<210>  4034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4034
uaaucaauac ggaggcuacu                                                   20


<210>  4035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4035
uuucaagggc cuguuucccu                                                   20


<210>  4036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4036
agggccuguu ucccuugccu                                                   20


<210>  4037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4037
cuugccucca uaacuguugu                                                   20


<210>  4038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4038
aaaccucuua aaacucccca                                                   20


<210>  4039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4039
cuuauuaggc ugagacacuu                                                   20


<210>  4040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4040
cugacuauuc cuggacuaca                                                   20


<210>  4041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4041
uggacuacag cuauaucuca                                                   20


<210>  4042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4042
ucccaaucca aagccuccuu                                                   20


<210>  4043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4043
caauccaaag ccuccuuugu                                                   20


<210>  4044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4044
cccauuuuac cuguccuaaa                                                   20


<210>  4045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4045
ggaucugcgc cuuaucaacc                                                   20


<210>  4046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4046
guucuggauc ucaaacaugc                                                   20


<210>  4047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4047
ggaucucaaa caugcuuucu                                                   20


<210>  4048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4048
uuacuauucc uuugcacccg                                                   20


<210>  4049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4049
uuugcacccg ucaucccagc                                                   20


<210>  4050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4050
cuuucacuuu gacugacccu                                                   20


<210>  4051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4051
cuuugacuga cccugacacc                                                   20


<210>  4052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4052
cagacagccc ccauuacuuc                                                   20


<210>  4053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4053
aucaagccca aauuucuucc                                                   20


<210>  4054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4054
uccucaucug uuaccuaucu                                                   20


<210>  4055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4055
ucaucuguua ccuaucuugg                                                   20


<210>  4056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4056
cauaaaaaca caugugcucu                                                   20


<210>  4057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4057
acaaaacaac aacuccuuuc                                                   20


<210>  4058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4058
uuccuaggca ugguuagcgu                                                   20


<210>  4059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4059
uaggcauggu uagcgugguc                                                   20


<210>  4060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4060
gaccacgcua accaugccua                                                   20


<210>  4061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4061
uacacaagag ccaggaccac                                                   20


<210>  4062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4062
guccaaacaa cuugaccuua                                                   20


<210>  4063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4063
cauaacuucc aaaaucuauu                                                   20


<210>  4064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4064
aaaaucuauu uucuuccuca                                                   20


<210>  4065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4065
uccucauacc ugacacauau                                                   20


<210>  4066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4066
ucauaccuga cacauauacu                                                   20


<210>  4067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4067
gcuucccggc uccuucagcu                                                   20


<210>  4068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4068
cggcuccuuc agcuguacuc                                                   20


<210>  4069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4069
gcuguacuca cucuuuguua                                                   20


<210>  4070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4070
uggcccagac cucaaucugg                                                   20


<210>  4071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4071
ugauaccaca ccugaccccc                                                   20


<210>  4072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4072
ccccauuucc ccauauuucc                                                   20


<210>  4073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4073
ccauauuucc uucuuuccug                                                   20


<210>  4074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4074
uucuuuccug uuccucaccc                                                   20


<210>  4075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4075
uuccuguucc ucacccugau                                                   20


<210>  4076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4076
uguuccucac ccugaucaug                                                   20


<210>  4077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4077
ucacccugau caugcuugau                                                   20


<210>  4078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4078
accaggccua aucgccacac                                                   20


<210>  4079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4079
aagagguggg cuaguggcuu                                                   20


<210>  4080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4080
uuuccaucau ggaaaucuau                                                   20


<210>  4081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4081
aucauggaaa ucuauccuca                                                   20


<210>  4082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4082
augauggaaa ggaaaugaga                                                   20


<210>  4083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4083
uugaggauag auuuccauga                                                   20


<210>  4084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4084
caguguucca ucugcuauuc                                                   20


<210>  4085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4085
aucugcuauu cuacuacucc                                                   20


<210>  4086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4086
acuacuccuc agggauuauu                                                   20


<210>  4087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4087
ggaccccucc cuucccuaca                                                   20


<210>  4088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4088
cuacacauca agcucgagga                                                   20


<210>  4089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4089
uacagggucu gagaaggcca                                                   20


<210>  4090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4090
cagacccugu aggaaaggcc                                                   20


<210>  4091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4091
cuucugucag acacaauucc                                                   20


<210>  4092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4092
gucagacaca auuccucagu                                                   20


<210>  4093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4093
ucaguuuagc cuucccaccu                                                   20


<210>  4094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4094
caccucaaua cagucugaua                                                   20


<210>  4095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4095
ggcucuuagu auucagugaa                                                   20


<210>  4096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4096
gugaaaccuu uauaucccuu                                                   20


<210>  4097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4097
cugaauacua agagccugaa                                                   20


<210>  4098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4098
agaaaaguag aacagacuaa                                                   20


<210>  4099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4099
ugaagacgga ggaccguaag                                                   20


<210>  4100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4100
acuuuucuug aagacggagg                                                   20


<210>  4101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4101
cuucucagaa uucaggccug                                                   20


<210>  4102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4102
cagaauucag gccuguccuc                                                   20


<210>  4103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4103
gagaagggaa agugauaaaa                                                   20


<210>  4104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4104
ggccuguccu cggaaugcua                                                   20


<210>  4105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4105
gaggacaggc cugaauucug                                                   20


<210>  4106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4106
agacaccaga ccaacuugga                                                   20


<210>  4107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4107
ggggcacagu ccaaguuggu                                                   20


<210>  4108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4108
gucuagucau acuccuauuc                                                   20


<210>  4109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4109
ccguucucaa cuacucauac                                                   20


<210>  4110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4110
caacuacuca uacaugcccu                                                   20


<210>  4111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4111
ccaagccauc acagcugaua                                                   20


<210>  4112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4112
agaguuaaga guggcaguuu                                                   20


<210>  4113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4113
gcauaguccu gccagcaaag                                                   20


<210>  4114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4114
uaguccuuuu auaccuguuu                                                   20


<210>  4115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4115
ccuucucuua uuccauuuag                                                   20


<210>  4116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4116
cuuauuccau uuaguuuuuc                                                   20


<210>  4117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4117
auuuaguuuu ucaauucaua                                                   20


<210>  4118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4118
auucauacaa aaccguaucc                                                   20


<210>  4119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4119
uacaaaaccg uauccaggcc                                                   20


<210>  4120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4120
auacgacaaa cguuucuucu                                                   20


<210>  4121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4121
ucuaacaucc ccacaauauc                                                   20


<210>  4122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4122
aacaucccca caauaucacc                                                   20


<210>  4123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4123
gcuuaaucuc ucccauucua                                                   20


<210>  4124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4124
agguucccac gccgccccua                                                   20


<210>  4125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4125
cacgccgccc cuaaucccgc                                                   20


<210>  4126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4126
agcgggauua ggggcggcgu                                                   20


<210>  4127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4127
cagggcugcu ucaagcggga                                                   20


<210>  4128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4128
cucuccauac caccccccaa                                                   20


<210>  4129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4129
ccgccccaac acuucaacac                                                   20


<210>  4130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4130
acacuauuuu auuuuucuua                                                   20


<210>  4131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4131
uauuaauaua agaaggcagg                                                   20


<210>  4132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4132
uauauuaaua agaaaaauaa                                                   20


<210>  4133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4133
ugccuucuua uauuaauaag                                                   20


<210>  4134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4134
ggccaucugg gcguauacau                                                   20


<210>  4135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4135
guuacuucag gccaucuggg                                                   20


<210>  4136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4136
ucaguuacuu caggccaucu                                                   20


<210>  4137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4137
uuugugauuc uucaguuacu                                                   20


<210>  4138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4138
cuucuuuugu gauucuucag                                                   20


<210>  4139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4139
accacaaaag aaguguaaau                                                   20


<210>  4140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4140
uuuguggugg aaugucauca                                                   20


<210>  4141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4141
caagguaaug ucaucaguua                                                   20


<210>  4142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4142
cugguucauc cuggcucaaa                                                   20


<210>  4143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4143
uccuggcuca aaaagcaccc                                                   20


<210>  4144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4144
uuuaccuacc caaauccuau                                                   20


<210>  4145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4145
cugacucucu uuucggacuc                                                   20


<210>  4146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4146
gacucagccc accugcaccc                                                   20


<210>  4147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4147
ccugggugca ggugggcuga                                                   20


<210>  4148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4148
cacggacgcg caugaaaucu                                                   20


<210>  4149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4149
ugcgcguccg ugugaagaga                                                   20


<210>  4150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4150
ccagauuuca ugcgcguccg                                                   20


<210>  4151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4151
cauucacucc ccacucacuc                                                   20


<210>  4152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4152
cuccccacuc acucacugac                                                   20


<210>  4153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4153
aguccugcaa gcucuguuca                                                   20


<210>  4154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4154
ugcuaagugc ccuacacaga                                                   20


<210>  4155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4155
cuuuuacauu uuauuuuuac                                                   20


<210>  4156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4156
auguuuagau uuuuuuuuuu                                                   20


<210>  4157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4157
ugccauucuc cugccucagc                                                   20


<210>  4158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4158
ccugccucag ccucccgagu                                                   20


<210>  4159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4159
acuaaaaaua caaaaaacca                                                   20


<210>  4160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4160
ccauguuagc caggaugguc                                                   20


<210>  4161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4161
gcacugugcu guacaagucu                                                   20


<210>  4162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4162
caccaugaca aaauugccag                                                   20


<210>  4163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4163
auacagucau gcauccauau                                                   20


<210>  4164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4164
ugucaucaga uuacaccgga                                                   20


<210>  4165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4165
gguguaaucu gaugacagga                                                   20


<210>  4166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4166
ccugcugggg gauuucagcg                                                   20


<210>  4167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4167
gcguguuucu agagagucgg                                                   20


<210>  4168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4168
agagagucgg uugcacgcuc                                                   20


<210>  4169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4169
accuccagag accuugccug                                                   20


<210>  4170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4170
gccuuccauu cccaccugca                                                   20


<210>  4171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4171
auucccaccu gcauacucuu                                                   20


<210>  4172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4172
caccugcaua cucuugcccu                                                   20


<210>  4173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4173
ggaggagcuu guuaucguag                                                   20


<210>  4174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4174
aaacacgccc uuucugacca                                                   20


<210>  4175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4175
gaccaccacu uuccuuuucu                                                   20


<210>  4176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4176
uuuucuccca acuccaauau                                                   20


<210>  4177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4177
cccaacucca auauuuucau                                                   20


<210>  4178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4178
uugacgccag ccuuucacgu                                                   20


<210>  4179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4179
cgucugccuc ucacucaccu                                                   20


<210>  4180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4180
ugguccaguc ugccauccac                                                   20


<210>  4181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4181
ccucugugag uacaauaacu                                                   20


<210>  4182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4182
cucuggcugu gcucagccgc                                                   20


<210>  4183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4183
ggucucacuc acaaaccacu                                                   20


<210>  4184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4184
aaguccauuu cucugccuga                                                   20


<210>  4185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4185
cugccugacu uauuuauuuu                                                   20


<210>  4186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4186
aagcauguua uuaucaagua                                                   20


<210>  4187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4187
guaacuauug ccauuucaca                                                   20


<210>  4188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4188
cagacgaaga gauagacaca                                                   20


<210>  4189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4189
ucugugaaau ggcaauaguu                                                   20


<210>  4190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4190
ugugugucua ucucuucguc                                                   20


<210>  4191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4191
ccuuucuccu uaaaccccca                                                   20


<210>  4192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4192
ccuuaaaccc ccaaauccuu                                                   20


<210>  4193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4193
cccccagccu gccuuauagu                                                   20


<210>  4194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4194
uauuccaaug agaaaauaga                                                   20


<210>  4195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4195
aaugagaaaa uagacucaau                                                   20


<210>  4196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4196
cauuggaaua ggaagcaagg                                                   20


<210>  4197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4197
cucuuuauug agucuauuuu                                                   20


<210>  4198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4198
accuuccccu gugauuaugg                                                   20


<210>  4199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4199
ccugugauua uggcugcacc                                                   20


<210>  4200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4200
accugugcac uaggauccau                                                   20


<210>  4201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4201
caccuccuaa gagaugcucc                                                   20


<210>  4202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4202
cugucucaac uguaacacuu                                                   20


<210>  4203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4203
aucagcucug ggccaucauc                                                   20


<210>  4204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4204
ugcuucccca aggauauagg                                                   20


<210>  4205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4205
ccaaggauau agggaaaacc                                                   20


<210>  4206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4206
cuauauccuu ggggaagcag                                                   20


<210>  4207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4207
agguuuuccc uauauccuug                                                   20


<210>  4208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4208
ugcauugucu cuacacaggc                                                   20


<210>  4209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4209
uggugaucuc cacauggcua                                                   20


<210>  4210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4210
gauuuagcca uguggagauc                                                   20


<210>  4211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4211
uuucucaccu ugcuuguccc                                                   20


<210>  4212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4212
caccuugcuu gucccguggg                                                   20


<210>  4213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4213
uccuccugga caugcucccu                                                   20


<210>  4214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4214
augacagggg acucacagag                                                   20


<210>  4215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4215
agcccagcau cuccccuaag                                                   20


<210>  4216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4216
augugacacc uuggccaucu                                                   20


<210>  4217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4217
ccagauggcc aaggugucac                                                   20


<210>  4218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4218
gggugcaugg guuugagcca                                                   20


<210>  4219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4219
ccacuaagcc acuccucucu                                                   20


<210>  4220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4220
aaauagcacu cacagcaauc                                                   20


<210>  4221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4221
cugugucccc auucaaaucu                                                   20


<210>  4222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4222
aaucucagcu ugaauuguau                                                   20


<210>  4223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4223
agcugagauu ugaaugggga                                                   20


<210>  4224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4224
cagaauuccc acguguugug                                                   20


<210>  4225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4225
gggaaauaca auucaagcug                                                   20


<210>  4226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4226
cacguguugu gggagggacc                                                   20


<210>  4227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4227
auuaccuccc ccuggguccc                                                   20


<210>  4228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4228
caugcuauuc ucaugguagu                                                   20


<210>  4229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4229
caugguagug aauaagucuc                                                   20


<210>  4230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4230
cuaccaugag aauagcaugg                                                   20


<210>  4231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4231
auuuuugcuu ccuccucauu                                                   20


<210>  4232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4232
uccucauuuu cucuugccuc                                                   20


<210>  4233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4233
cuugccuccg ccauguaaga                                                   20


<210>  4234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4234
uacauggcgg aggcaagaga                                                   20


<210>  4235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4235
uuucccguca ugauucugag                                                   20


<210>  4236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4236
cgucaugauu cugagaccuc                                                   20


<210>  4237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4237
gagaccuccg cagccacgug                                                   20


<210>  4238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4238
acguggcugc ggaggucuca                                                   20


<210>  4239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4239
uccuagucuc agguaugucu                                                   20


<210>  4240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4240
uagucucagg uaugucuuua                                                   20


<210>  4241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4241
gguaucuuuu aagcaacacc                                                   20


<210>  4242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4242
acauuuucag guaucuuuua                                                   20


<210>  4243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4243
aagucauuuc cacauuuuca                                                   20


<210>  4244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4244
gccuguuacc caauuucaaa                                                   20


<210>  4245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4245
aaauucugcc uguuacccaa                                                   20


<210>  4246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4246
gagcccucca aacuguucca                                                   20


<210>  4247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4247
ucugagcccu ccaaacuguu                                                   20


<210>  4248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4248
ugucuucuuc ugagcccucc                                                   20


<210>  4249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4249
cacauuuucc ugucuucuuc                                                   20


<210>  4250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4250
aaacuuucuc acauuuuccu                                                   20


<210>  4251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4251
uagagacuug uucaauggcu                                                   20


<210>  4252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4252
auggcuuuga caaaaauacu                                                   20


<210>  4253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4253
uaucacuaug aguauuuuug                                                   20


<210>  4254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4254
ucaucugccc ccucugagac                                                   20


<210>  4255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4255
caacaaguuc cucaucugcc                                                   20


<210>  4256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4256
gcaaaucuca agggcagggg                                                   20


<210>  4257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4257
acguuccgca aaucucaagg                                                   20


<210>  4258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4258
accagauacc cuaaaucguc                                                   20


<210>  4259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4259
uccaccagau acccuaaauc                                                   20


<210>  4260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4260
aagcagcaaa gcauucaaga                                                   20


<210>  4261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4261
agaggugacu uggguacugu                                                   20


<210>  4262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4262
guuuugaacg ggaagcagag                                                   20


<210>  4263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4263
aaacagaaug uuuuuaacag                                                   20


<210>  4264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4264
cguucaaaac agaauguuuu                                                   20


<210>  4265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4265
gaaaauuugc agccuaauau                                                   20


<210>  4266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4266
gaacuuuugu gcucugcuuc                                                   20


<210>  4267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4267
acugcaauau uaggcugcaa                                                   20


<210>  4268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4268
uuucuacugc aauauuaggc                                                   20


<210>  4269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4269
ccucaaaaaa uggguuuuuc                                                   20


<210>  4270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4270
agccagcugc agaaauuugc                                                   20


<210>  4271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4271
gcagcuggcu ugaauuucuc                                                   20


<210>  4272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4272
ccaugguuuu gaggauuaac                                                   20


<210>  4273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4273
caacagcucc ucccaucaca                                                   20


<210>  4274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4274
uccuggggcu cuaggccugu                                                   20


<210>  4275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4275
ugugcugugu gcagcccagg                                                   20


<210>  4276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4276
gccaugccug gagcagcugg                                                   20


<210>  4277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4277
gagguggaag ccccaagacu                                                   20


<210>  4278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4278
accucugaag ccacagccca                                                   20


<210>  4279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4279
augugguguu gagccugcag                                                   20


<210>  4280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4280
gugcaccugc aggcucaaca                                                   20


<210>  4281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4281
ugacuucugu gcaccugcag                                                   20


<210>  4282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4282
caaaccucaa uucuugacuu                                                   20


<210>  4283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4283
gaagacguag gaaaugcuug                                                   20


<210>  4284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4284
gaaaucuagg uggagguucc                                                   20


<210>  4285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4285
uacgucuucu gaaaucuagg                                                   20


<210>  4286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4286
gccuggacau ccaagcauuu                                                   20


<210>  4287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4287
ggguggggug cucauggaga                                                   20


<210>  4288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4288
ccaugagcac cccacccuga                                                   20


<210>  4289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4289
gcacuguccu accagagguu                                                   20


<210>  4290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4290
cuucugcacu guccuaccag                                                   20


<210>  4291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4291
gucugggggc ugugacccca                                                   20


<210>  4292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4292
ggggucugga ggacaguggc                                                   20


<210>  4293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4293
ccuggaaaau cugcagacaa                                                   20


<210>  4294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4294
aggagaacag ugcaaguugu                                                   20


<210>  4295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4295
ugggcuggca uugauugucu                                                   20


<210>  4296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4296
cauggucuug ggcagcucug                                                   20


<210>  4297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4297
cccauuugga auggcuguau                                                   20


<210>  4298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4298
aaaugggaga aauuggccaa                                                   20


<210>  4299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4299
agauacaaua gggauacagg                                                   20


<210>  4300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4300
auuuuacagg cucauaggug                                                   20


<210>  4301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4301
accuaugagc cuguaaaauc                                                   20


<210>  4302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4302
gcauugaccc aaaaguccac                                                   20


<210>  4303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4303
caacagucuc ucaaaguuuu                                                   20


<210>  4304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4304
aaaccaauca ugccuuccca                                                   20


<210>  4305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4305
uguccucaca uuucaaaacc                                                   20


<210>  4306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4306
gccccugacc ccuccaaauu                                                   20


<210>  4307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4307
acucgcagcu ugaauugugu                                                   20


<210>  4308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4308
agcugcgagu ugaauggcaa                                                   20


<210>  4309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4309
gggagacaca auucaagcug                                                   20


<210>  4310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4310
cacauguugu gggagggagc                                                   20


<210>  4311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4311
auuaccucuc ccuggcuccc                                                   20


<210>  4312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4312
caugcuauuc ucgugauagu                                                   20


<210>  4313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4313
cgugauagug aauaagucuc                                                   20


<210>  4314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4314
cuaucacgag aauagcaugg                                                   20


<210>  4315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4315
gcuuuuguau ccuuuuuauu                                                   20


<210>  4316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4316
cuugcuguug ccauguaaga                                                   20


<210>  4317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4317
uacauggcaa cagcaagaga                                                   20


<210>  4318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4318
ccuccugccg ugauucugag                                                   20


<210>  4319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4319
gaggccugcc cagccaugug                                                   20


<210>  4320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4320
acauggcugg gcaggccuca                                                   20


<210>  4321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4321
ucccagucuu ggguaugucu                                                   20


<210>  4322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4322
cagucuuggg uaugucuuua                                                   20


<210>  4323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4323
ugcugcugau aaagacauac                                                   20


<210>  4324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4324
uuuucaugcu gcugauaaag                                                   20


<210>  4325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4325
cggagaaaag ccagaguccc                                                   20


<210>  4326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4326
ccgggaaggu ggagagcuaa                                                   20


<210>  4327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4327
ggggacucug gcuuuucucc                                                   20


<210>  4328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4328
uugcaggcuc cuucccaucu                                                   20


<210>  4329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4329
caucucuggg cuguuccagu                                                   20


<210>  4330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4330
agucuggggc agcacuucuc                                                   20


<210>  4331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4331
ccacuguguc cacggcccgu                                                   20


<210>  4332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4332
uccaguguuc ucuuugcaca                                                   20


<210>  4333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4333
cuuugcacac cgcccuguuu                                                   20


<210>  4334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4334
cuuuuccuuu uccuccaugg                                                   20


<210>  4335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4335
uuuuccucca uggcacucau                                                   20


<210>  4336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4336
uccauggcac ucaucaccau                                                   20


<210>  4337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4337
gcccuacuag agggagggcu                                                   20


<210>  4338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4338
auggaucuug uucacugcca                                                   20


<210>  4339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4339
cugccauacc cagcaucuag                                                   20


<210>  4340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4340
agaugcuggg uauggcagug                                                   20


<210>  4341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4341
guaauuaacu cagucauuaa                                                   20


<210>  4342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4342
cugcuuauac ugaguucacg                                                   20


<210>  4343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4343
cgacccgugg ggaagacaga                                                   20


<210>  4344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4344
ccacgggucg ugaacucagu                                                   20


<210>  4345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4345
auguagcccc uacugcacau                                                   20


<210>  4346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4346
ucccaugugc aguaggggcu                                                   20


<210>  4347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4347
cauagcccca gagggcaagg                                                   20


<210>  4348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4348
agcuguuucc cauagcccca                                                   20


<210>  4349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4349
ugucuauuaa acagagauga                                                   20


<210>  4350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4350
ccccagcccu gugggacaug                                                   20


<210>  4351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4351
ugucucauuc gccccagccc                                                   20


<210>  4352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4352
uccuuccugu cucauucgcc                                                   20


<210>  4353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4353
aagugcucca agagaggagc                                                   20


<210>  4354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4354
gagguggagu cucacucugu                                                   20


<210>  4355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4355
gcugggcaac agagugagac                                                   20


<210>  4356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4356
agcaauuccc cugccccagc                                                   20


<210>  4357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4357
ccugccccag ccucccuagu                                                   20


<210>  4358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4358
agaccagccu ggccaacaug                                                   20


<210>  4359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4359
acaguuauau cauguuuaaa                                                   20


<210>  4360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4360
auuugggguc uguaccuuaa                                                   20


<210>  4361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4361
auaaaguggu uacauuugua                                                   20


<210>  4362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4362
augucaauau auaaaccucc                                                   20


<210>  4363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4363
uuuuaccagc ugccaaauau                                                   20


<210>  4364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4364
uaugguggga uauuuggcag                                                   20


<210>  4365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4365
ucaauggagg gacagauuuu                                                   20


<210>  4366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4366
gcaauccaaa cauucaucaa                                                   20


<210>  4367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4367
agggguucag caauccaaac                                                   20


<210>  4368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4368
uccagggguu cagcaaucca                                                   20


<210>  4369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4369
auaagagcaa acagaagugu                                                   20


<210>  4370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4370
guuugcucuu auugaauuuc                                                   20


<210>  4371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4371
cuuagcucuc cccgcuccac                                                   20


<210>  4372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4372
ggcugcgcug ccuccugccu                                                   20


<210>  4373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4373
caccccacca caugucuggg                                                   20


<210>  4374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4374
uauacccugu ucagucuuua                                                   20


<210>  4375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4375
gucuuuacug agucagaagc                                                   20


<210>  4376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4376
gacucaguaa agacugaaca                                                   20


<210>  4377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4377
uacggaaaag cgugcugcug                                                   20


<210>  4378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4378
guaagaagcu cugcuguaaa                                                   20


<210>  4379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4379
aggaugaggc uggagcuggc                                                   20


<210>  4380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4380
auaucauuag uaccucuuug                                                   20


<210>  4381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4381
uuaggauaaa uuccuaagaa                                                   20


<210>  4382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4382
uaagaaauca aauagcuagg                                                   20


<210>  4383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4383
uaggaauuua uccuaaggaa                                                   20


<210>  4384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4384
caguuugcua cugacuagag                                                   20


<210>  4385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4385
ggcuguuuuu guaccuuuaa                                                   20


<210>  4386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4386
aaucagggag aaaaaaugag                                                   20


<210>  4387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4387
cccugauuag aaaugacguc                                                   20


<210>  4388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4388
guaacucauu uuuucucccu                                                   20


<210>  4389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4389
aauaccguuu auuccguaac                                                   20


<210>  4390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4390
ggagaaaaau aaccucacuc                                                   20


<210>  4391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4391
ccagaaggcu agccuauugu                                                   20


<210>  4392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4392
acugggauuu acuuuuguau                                                   20


<210>  4393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4393
aagcacagua caaaaucaag                                                   20


<210>  4394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4394
ugauuuugua cugugcuuag                                                   20


<210>  4395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4395
ugacuucuug auuuuguacu                                                   20


<210>  4396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4396
uggagucaaa cuuaucagcc                                                   20


<210>  4397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4397
auggaaaaaa auacaauaaa                                                   20


<210>  4398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4398
auagaaaauu uuaauuuuca                                                   20


<210>  4399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4399
aguuuguuga uugauuuuug                                                   20


<210>  4400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4400
uuuuggcugu ggagcuuuug                                                   20


<210>  4401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4401
uuuuuucauu uuggcugugg                                                   20


<210>  4402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4402
aagacaaaca aauguagaua                                                   20


<210>  4403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4403
uuaaguuaaa caauuaucua                                                   20


<210>  4404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4404
caaauauacc cuuucuccuc                                                   20


<210>  4405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4405
ccuccuucug ggcacuuggu                                                   20


<210>  4406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4406
gggcacuugg ugugauugca                                                   20


<210>  4407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4407
uacauuugac cuuaggugug                                                   20


<210>  4408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4408
ccuaagcgag acacaugacc                                                   20


<210>  4409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4409
uucuccuaag cgagacacau                                                   20


<210>  4410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4410
cauuuccuuc uccuaagcga                                                   20


<210>  4411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4411
guucacauuu ccuucuccua                                                   20


<210>  4412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4412
acacaaaagu gacccacaac                                                   20


<210>  4413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4413
gucagccuca guguucagca                                                   20


<210>  4414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4414
gcaauguucu gaaugauggu                                                   20


<210>  4415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4415
gaaugauggu ugcuuuauca                                                   20


<210>  4416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4416
gaacauugcu gaacacugag                                                   20


<210>  4417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4417
ggggugaggg uaaugaagua                                                   20


<210>  4418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4418
uuacccucac cccagaacca                                                   20


<210>  4419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4419
cuacuucauu acccucaccc                                                   20


<210>  4420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4420
gucucaccuc acauguccau                                                   20


<210>  4421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4421
agccccugag auuuggggcg                                                   20


<210>  4422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4422
agcacaugca cgccccaaau                                                   20


<210>  4423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4423
gcuuccagca caugcacgcc                                                   20


<210>  4424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4424
gauggauucc uccagcacug                                                   20


<210>  4425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4425
uccagcacug cucgugggaa                                                   20


<210>  4426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4426
cacgagcagu gcuggaggaa                                                   20


<210>  4427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4427
ugugcccuuu aucucgaaau                                                   20


<210>  4428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4428
agauaaaggg cacaugaaug                                                   20


<210>  4429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4429
acuuccagga auuuaugaaa                                                   20


<210>  4430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4430
aggaauuuau gaaacagaua                                                   20


<210>  4431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4431
uggaagugga auuucgagau                                                   20


<210>  4432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4432
uaaauuccug gaaguggaau                                                   20


<210>  4433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4433
gucuuuugcu auugcaaucc                                                   20


<210>  4434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4434
guugguuguu ucugucuuuu                                                   20


<210>  4435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4435
uauugguugg uguuuccguu                                                   20


<210>  4436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4436
caaugucuuu agccaauuuc                                                   20


<210>  4437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4437
auguauguuu cacaaugucu                                                   20


<210>  4438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4438
uucuauguau guuucacaau                                                   20


<210>  4439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4439
gguugcagau uauuucauuc                                                   20


<210>  4440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4440
gagauuaggg cuagguuaag                                                   20


<210>  4441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4441
gagauagucu acuuuuauaa                                                   20


<210>  4442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4442
uggggcuguu auaacaaguu                                                   20


<210>  4443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4443
acaaauuugc uggcuucaaa                                                   20


<210>  4444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4444
aauaacaaaa acguauucuc                                                   20


<210>  4445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4445
cuugcaguua uggaagccag                                                   20


<210>  4446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4446
auaacugcaa gagaauacgu                                                   20


<210>  4447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4447
ggcuuccaua acugcaagag                                                   20


<210>  4448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4448
auacuucugg cuuccauaac                                                   20


<210>  4449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4449
uuccauacuu cuggcuucca                                                   20


<210>  4450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4450
uccccuagag cuuugggaga                                                   20


<210>  4451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4451
uugcuucuuc cagcuccuuu                                                   20


<210>  4452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4452
uccagcuccu uugggggcuc                                                   20


<210>  4453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4453
agcuccuuug ggggcuccug                                                   20


<210>  4454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4454
uuggcuuaug ucggcacagc                                                   20


<210>  4455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4455
gugucucaag uaucucuccc                                                   20


<210>  4456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4456
cuucugauau cagucauugg                                                   20


<210>  4457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4457
gauaucaguc auuggauuua                                                   20


<210>  4458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4458
aaauaagguc acauucaaaa                                                   20


<210>  4459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4459
aaaguaccag ggguuagucu                                                   20


<210>  4460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4460
acccacuacc guggguaaca                                                   20


<210>  4461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4461
cucagaaggu ggugguucag                                                   20


<210>  4462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4462
gagggaaaac cacuguuacc                                                   20


<210>  4463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4463
ggagugggag gaagaugaac                                                   20


<210>  4464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4464
ucccacuccu gaaccaccac                                                   20


<210>  4465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4465
ucuuccuccc acuccugaac                                                   20


<210>  4466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4466
cuguauaucc uuucaaacua                                                   20


<210>  4467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4467
aacuauucac guuuuaaaaa                                                   20


<210>  4468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4468
cguuuuaaaa aaaacauuuu                                                   20


<210>  4469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4469
uguaaauuua aaaaaauuga                                                   20


<210>  4470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4470
auuuuuuuaa auuuacauga                                                   20


<210>  4471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4471
cacaaaaaga ugcccccucc                                                   20


<210>  4472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4472
aaauguugaa auguacacuc                                                   20


<210>  4473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4473
acauuuugaa cgggcauacu                                                   20


<210>  4474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4474
gagguuggag aagguagcca                                                   20


<210>  4475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4475
ccaaccucag aaacuuggag                                                   20


<210>  4476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4476
aucuacucau ucagucuaug                                                   20


<210>  4477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4477
gucuaugagg ggaaggcaau                                                   20


<210>  4478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4478
ccucauagac ugaaugagua                                                   20


<210>  4479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4479
agccauugcc uuccccucau                                                   20


<210>  4480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4480
ucccucuaaa aaugccacuu                                                   20


<210>  4481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4481
ccccacaagc auccucaagg                                                   20


<210>  4482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4482
cuucacccca caagcauccu                                                   20


<210>  4483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4483
uucccuucac cccacaagca                                                   20


<210>  4484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4484
ugaguuauuc uuucccuuca                                                   20


<210>  4485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4485
gggcagaggg gaccauccuc                                                   20


<210>  4486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4486
uccuucaggg cagaggggac                                                   20


<210>  4487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4487
ccuccugccu uccuccuuca                                                   20


<210>  4488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4488
gggucaacac ccauccuuuu                                                   20


<210>  4489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4489
ggggccuccc cuccaccaca                                                   20


<210>  4490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4490
gacuuacccu gauugcuggu                                                   20


<210>  4491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4491
cccacacccu ggccagcaaa                                                   20


<210>  4492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4492
caaauggguu cccccacacc                                                   20


<210>  4493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4493
cccucuucuc aaauggguuc                                                   20


<210>  4494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4494
uuugggcaac uuaugggagg                                                   20


<210>  4495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4495
ucccucacca auuaccccuc                                                   20


<210>  4496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4496
caucccauau ccuccacugc                                                   20


<210>  4497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4497
aucugucgca gagcccaggg                                                   20


<210>  4498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4498
uuccuccccc accucccuca                                                   20


<210>  4499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4499
ucccccaccu cccucagaac                                                   20


<210>  4500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4500
gagggaggug ggggaggaag                                                   20


<210>  4501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4501
ugggccuggg gacauccaug                                                   20


<210>  4502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4502
ucauucucug ggugcacggu                                                   20


<210>  4503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4503
cugggugcac gguaacgacc                                                   20


<210>  4504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4504
cugcugcucc ccuuugggac                                                   20


<210>  4505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4505
ugcuccaggg gaggccuuug                                                   20


<210>  4506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4506
ucaucaaagg ccuccccugg                                                   20


<210>  4507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4507
aauuacaggc aacaggaagg                                                   20


<210>  4508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4508
uguugccugu aauuggaauu                                                   20


<210>  4509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4509
ccuuccuguu gccuguaauu                                                   20


<210>  4510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4510
acuuuguuug caaagaccuc                                                   20


<210>  4511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4511
gagcaggcca uuucacucgg                                                   20


<210>  4512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4512
cucggaaucu gcugugcauc                                                   20


<210>  4513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4513
gagugaaaug gccugcucug                                                   20


<210>  4514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4514
ccuuuguuuc uucccaguau                                                   20


<210>  4515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4515
ucccaguauc gacagcccuu                                                   20


<210>  4516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4516
caguaucgac agcccuucca                                                   20


<210>  4517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4517
agaaagagca agccucaugu                                                   20


<210>  4518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4518
ggaagggcug ucgauacugg                                                   20


<210>  4519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4519
ccuuuucauc cuccugccug                                                   20


<210>  4520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4520
uccuccugcc ugguacacaa                                                   20


<210>  4521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4521
ugaacauggu guguaaaagg                                                   20


<210>  4522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4522
agaaaucaac uggacaagca                                                   20


<210>  4523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4523
uuuuacacac cauguucaag                                                   20


<210>  4524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4524
auuugcaaag auuccuuuua                                                   20


<210>  4525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4525
ggaaagcuga gcuugugccu                                                   20


<210>  4526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4526
agaagauuca auuugcaaag                                                   20


<210>  4527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4527
augguaggca caagcucagc                                                   20


<210>  4528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4528
gaauguaccu auaugacguc                                                   20


<210>  4529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4529
gaauucuaug guaggcacaa                                                   20


<210>  4530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4530
gguuuuaagu uugcaaagac                                                   20


<210>  4531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4531
agggauuuau acuacaaaga                                                   20


<210>  4532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4532
aggagcagcu aguugguaag                                                   20


<210>  4533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4533
aaacuuagcc uggacccccu                                                   20


<210>  4534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4534
acuggccuua accuggcagc                                                   20


<210>  4535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4535
uuccacuggc cuuaaccugg                                                   20


<210>  4536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4536
gugggcagcg aggaguccac                                                   20


<210>  4537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4537
gaagucucac uggucagcag                                                   20


<210>  4538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4538
gaaucaaucc uacuguggac                                                   20


<210>  4539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4539
uggguccacc uugucuccug                                                   20


<210>  4540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4540
guguuuccug gguccaccuu                                                   20


<210>  4541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4541
gccgggccca ccuuuucagu                                                   20


<210>  4542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4542
agcccaguua ggauuuggga                                                   20


<210>  4543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4543
ucccucugcg cguaaucuga                                                   20


<210>  4544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4544
cucugcgcgu aaucugacgc                                                   20


<210>  4545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4545
gccucgcccu ccccaaacag                                                   20


<210>  4546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4546
guuaauguuu aaucagauag                                                   20


<210>  4547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4547
aggguguggg ugcuugacgc                                                   20


<210>  4548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4548
gcagcgacgu cgaggcgcuc                                                   20


<210>  4549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4549
guucaggguc ugagccugga                                                   20


<210>  4550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4550
gggucugagc cuggaggagu                                                   20


<210>  4551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4551
gcgcgccccu ucacgcgccc                                                   20


<210>  4552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4552
cgcgcccugc uccugaacuu                                                   20


<210>  4553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4553
ggagcagggc gcgugaaggg                                                   20


<210>  4554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4554
gcuccugcac aguccucccc                                                   20


<210>  4555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4555
gaggaggacg gccuggccga                                                   20


<210>  4556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4556
gccaggccgu ccuccucgga                                                   20


<210>  4557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4557
gugcucgggu gcuucggcca                                                   20


<210>  4558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4558
accgcugcgc caaggugcgg                                                   20


<210>  4559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4559
ccccggccuc ccaucccuac                                                   20


<210>  4560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4560
ucucgggccu caguuucccc                                                   20


<210>  4561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4561
ccccauguaa gagaggaagu                                                   20


<210>  4562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4562
ucucuuacau ggggggaaac                                                   20


<210>  4563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4563
cuuggcacga ucuuggggac                                                   20


<210>  4564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4564
gugggaaggu ucgcgggguu                                                   20


<210>  4565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4565
cacugaauag cgcagccgca                                                   20


<210>  4566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4566
cgggguuggg agacccggag                                                   20


<210>  4567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4567
ucggccuccg ggucucccaa                                                   20


<210>  4568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4568
caguuucugc cucgccgcgg                                                   20


<210>  4569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4569
gccucgccgc ggcacaggug                                                   20


<210>  4570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4570
cccaccugug ccgcggcgag                                                   20


<210>  4571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4571
cuccuucacc caccugugcc                                                   20


<210>  4572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4572
aggcauucac uccuucaccc                                                   20


<210>  4573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4573
caguacguuc caggcauuca                                                   20


<210>  4574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4574
cugugccugg ugcaguuccc                                                   20


<210>  4575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4575
gauuugguuu ggaaaacaug                                                   20


<210>  4576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4576
aaaccaaauc ggaacccacu                                                   20


<210>  4577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4577
cuccaggccc uccacccucc                                                   20


<210>  4578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4578
caccccgccc cugucucggg                                                   20


<210>  4579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4579
uuaugacaca gaacucaugc                                                   20


<210>  4580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4580
gugucauaaa gaaauugccu                                                   20


<210>  4581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4581
aucuguuuca gccgaagaaa                                                   20


<210>  4582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4582
gccgaagaaa agaaccagcu                                                   20


<210>  4583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4583
gcugaaacag auggaauacu                                                   20


<210>  4584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4584
ucggcugaaa cagauggaau                                                   20


<210>  4585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4585
uuucuucggc ugaaacagau                                                   20


<210>  4586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4586
gcugguucuu uucuucggcu                                                   20


<210>  4587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4587
ccccugcccc uucagcuggu                                                   20


<210>  4588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4588
cgaggcccau uggcguccuu                                                   20


<210>  4589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4589
cugccugagu ccuaaaggac                                                   20


<210>  4590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4590
ggcccucagg cugugggaag                                                   20


<210>  4591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4591
cacagccuga gggccagaag                                                   20


<210>  4592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4592
ucccggggcg agaccacuag                                                   20


<210>  4593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4593
cggggcgaga ccacuagcuu                                                   20


<210>  4594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4594
aaguauuacc agcccaggac                                                   20


<210>  4595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4595
guguccccca gcuuggaguc                                                   20


<210>  4596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4596
accccacauc ugacuccaag                                                   20


<210>  4597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4597
ucucacuagc uguggugcuu                                                   20


<210>  4598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4598
ucuccccauc ugcugccacu                                                   20


<210>  4599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4599
cuucaucucc ccaucugcug                                                   20


<210>  4600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4600
guugaccaug agugaacuua                                                   20


<210>  4601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4601
cucaugguca acagaacuuu                                                   20


<210>  4602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4602
ccucugcccc aggagcugug                                                   20


<210>  4603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4603
gccacucaca gcugccugcc                                                   20


<210>  4604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4604
gucugagugu gcuggguggc                                                   20


<210>  4605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4605
uuguucccug agccuuugac                                                   20


<210>  4606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4606
cugagccuuu gacuuucucg                                                   20


<210>  4607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4607
cgagggaugu ugugggguug                                                   20


<210>  4608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4608
uauccuggcc acaaccccac                                                   20


<210>  4609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4609
aguuaccacu gcuccaaaac                                                   20


<210>  4610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4610
ggaaauagug aguaccccau                                                   20


<210>  4611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4611
agaacaguug uuuuggagca                                                   20


<210>  4612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4612
gguggucaua cagccucugc                                                   20


<210>  4613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4613
ucucuggugg aaguuuggaa                                                   20


<210>  4614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4614
cugguggaag uuuggaacag                                                   20


<210>  4615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4615
accagagaag aaacauccuc                                                   20


<210>  4616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4616
aaacuuccac cagagaagaa                                                   20


<210>  4617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4617
uuuauucauu cauucaaugg                                                   20


<210>  4618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4618
uucauucaau gguuauuuug                                                   20


<210>  4619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4619
uucaaugguu auuuuguggg                                                   20


<210>  4620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4620
augguuauuu ugugggaauc                                                   20


<210>  4621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4621
cacaaaauaa ccauugaaug                                                   20


<210>  4622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4622
auucccacaa aauaaccauu                                                   20


<210>  4623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4623
aaauucgauu cccacaaaau                                                   20


<210>  4624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4624
uucuaaauuc gauucccaca                                                   20


<210>  4625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4625
gcuugccaaa aaauauuuuc                                                   20


<210>  4626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4626
uuuagucaug agaaacugag                                                   20


<210>  4627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4627
caugacuaaa agaaaaggau                                                   20


<210>  4628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4628
aaugcaccug gggugaccuc                                                   20


<210>  4629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4629
agaacugaca cuccacugca                                                   20


<210>  4630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4630
ggaaacccag uucuaaugca                                                   20


<210>  4631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4631
uucaauuuuu auuuagcgga                                                   20


<210>  4632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4632
auuuuuauuu agcggaaggc                                                   20


<210>  4633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4633
gcuaaauaaa aauugaauga                                                   20


<210>  4634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4634
gaugggucuu ugaagcauua                                                   20


<210>  4635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4635
aagacccauc ugaaaaugcc                                                   20


<210>  4636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4636
gcgaugaugg ugucaugaga                                                   20


<210>  4637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4637
caugacacca ucaucgcuga                                                   20


<210>  4638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4638
aggauuagga gguaccauga                                                   20


<210>  4639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4639
ugguaccucc uaauccuaga                                                   20


<210>  4640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4640
cagcucugua ucuuuguuca                                                   20


<210>  4641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4641
accucugguu uucccagcuc                                                   20


<210>  4642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4642
uuuucuuuuu uuuuugagau                                                   20


<210>  4643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4643
uuuuuuuuug agauggaguu                                                   20


<210>  4644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4644
cucuuguugc ccaggcugga                                                   20


<210>  4645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4645
agugguucuc cugccucagc                                                   20


<210>  4646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4646
ccugccucag ccucccaaga                                                   20


<210>  4647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4647
ugggaggcug aggcaggaga                                                   20


<210>  4648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4648
cuacuaaaaa uacaaaaauu                                                   20


<210>  4649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4649
ccacguuggc caggcuaguc                                                   20


<210>  4650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4650
agcacuuugg gaggcugagg                                                   20


<210>  4651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4651
uuauccaccg ucugaaaugu                                                   20


<210>  4652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4652
gacgguggau aaagaacugu                                                   20


<210>  4653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4653
uaacauuuua cauuucagac                                                   20


<210>  4654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4654
cgucaggugc uaccaucaaa                                                   20


<210>  4655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4655
cacaacuaaa uuaaaaauaa                                                   20


<210>  4656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4656
uauauuuugc ugcauagauu                                                   20


<210>  4657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4657
uccaagcaga cucugauugc                                                   20


<210>  4658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4658
aagcagacuc ugauugccca                                                   20


<210>  4659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4659
aaaauccaaa caaguucuga                                                   20


<210>  4660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4660
gagguucaaa accguuuugg                                                   20


<210>  4661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4661
aaaccguuuu ggcccuaagg                                                   20


<210>  4662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4662
acucugacug gaguccaaga                                                   20


<210>  4663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4663
ugaggcugug gggagccagu                                                   20


<210>  4664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4664
cuggcucccc acagccucau                                                   20


<210>  4665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4665
uaagcaggua ugucugccug                                                   20


<210>  4666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4666
acaugagauu uggaggggac                                                   20


<210>  4667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4667
aacacugagg accaaauuuc                                                   20


<210>  4668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4668
ucccccauga cccaaacacc                                                   20


<210>  4669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4669
cagggguucc ucccccauga                                                   20


<210>  4670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4670
cccgcuauga uuucccuuga                                                   20


<210>  4671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4671
cuugaaggcu gauuauuaaa                                                   20


<210>  4672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4672
agggaaauca uagcgggaga                                                   20


<210>  4673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4673
cucuugcuuc uucucuugcc                                                   20


<210>  4674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4674
ucucuugcca ugugauugau                                                   20


<210>  4675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4675
cuugccaugu gauugaucuc                                                   20


<210>  4676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4676
ccuucugcca ucagugaaag                                                   20


<210>  4677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4677
gccaucagug aaagcagcuu                                                   20


<210>  4678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4678
cugauggcag aaggugaagg                                                   20


<210>  4679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4679
ggugagggcc uuaagcugcu                                                   20


<210>  4680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4680
uggagagcuu gcagaaucau                                                   20


<210>  4681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4681
gcaagcucuc caggaagcau                                                   20


<210>  4682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4682
gcucaugauu cugcaagcuc                                                   20


<210>  4683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4683
uuguaaauua cucaccuuca                                                   20


<210>  4684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4684
gguauuccuu uauauagcaa                                                   20


<210>  4685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4685
uuuauauagc aacacaaaag                                                   20


<210>  4686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4686
cucucuuuaa gaaguguugc                                                   20


<210>  4687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4687
uaaagagaga gaaaagucaa                                                   20


<210>  4688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4688
gccugcauuu guagagcauc                                                   20


<210>  4689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4689
cagcaggccu augucauagg                                                   20


<210>  4690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4690
agcuccaaua uuuacugguu                                                   20


<210>  4691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4691
gguccacggu uuccuggcuc                                                   20


<210>  4692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4692
uggcuccaaa gcccaugauu                                                   20


<210>  4693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4693
cucaauuuau ucugacuggg                                                   20


<210>  4694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4694
gacuggggca ugggggaggg                                                   20


<210>  4695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4695
ucuguaccug cacccagcuc                                                   20


<210>  4696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4696
cauuuuugcc ugaauggcac                                                   20


<210>  4697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4697
ggcaaaaaug ggaacuacgg                                                   20


<210>  4698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4698
aaugugccau ucaggcaaaa                                                   20


<210>  4699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4699
caugguuaua uaacacuuuc                                                   20


<210>  4700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4700
uuaauuugcu uuuugguccg                                                   20


<210>  4701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4701
uuaucaucua cuauacucug                                                   20


<210>  4702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4702
uccaugucau cauguuccuc                                                   20


<210>  4703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4703
augucaucau guuccuccuu                                                   20


<210>  4704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4704
uccuugcaug gggccaggau                                                   20


<210>  4705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4705
gcaccaccac guaggugcca                                                   20


<210>  4706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4706
auggccuucu uccuggcuuc                                                   20


<210>  4707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4707
uccuggcuuc cuggugaaga                                                   20


<210>  4708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4708
uggcuuccug gugaagauga                                                   20


<210>  4709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4709
uggugaagau gaguggcgac                                                   20


<210>  4710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4710
ccaggaagcc aggaagaagg                                                   20


<210>  4711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4711
caaaaagggu ggcucaccag                                                   20


<210>  4712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4712
ugauagggcu gggccacugc                                                   20


<210>  4713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4713
gcaaugggcc uacuaagcac                                                   20


<210>  4714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4714
gauuuucagc aaugggccua                                                   20


<210>  4715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4715
guauagaauu cccuuuaagc                                                   20


<210>  4716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4716
auacagaaag ccaguaguua                                                   20


<210>  4717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4717
cuuuaagccu ggccaugccc                                                   20


<210>  4718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4718
uuugaaagac gaggagacug                                                   20


<210>  4719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4719
aaugaagaua gacguaccac                                                   20


<210>  4720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4720
gucuccucgu cuuucaaaug                                                   20


<210>  4721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4721
gaggggacca cacagacagc                                                   20


<210>  4722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4722
ugugccaaug caucugcugc                                                   20


<210>  4723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4723
guaggcagca gaugcauugg                                                   20


<210>  4724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4724
guggagccug agucauuuua                                                   20


<210>  4725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4725
uuugaagcug uugcuaucca                                                   20


<210>  4726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4726
aaggaauuuu ggacccuaga                                                   20


<210>  4727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4727
cucuggauag caacagcuuc                                                   20


<210>  4728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4728
uuaggacagg guggcccucc                                                   20


<210>  4729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4729
guggaggggc agaaagggga                                                   20


<210>  4730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4730
gccccuccac cgaagaugug                                                   20


<210>  4731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4731
ccucacccug gcccuagugc                                                   20


<210>  4732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4732
aaucuuaaaa aaacguuuuu                                                   20


<210>  4733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4733
gcaccaccuu cuagcccacc                                                   20


<210>  4734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4734
agcccaccuc guuuccuggc                                                   20


<210>  4735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4735
uggccucuaa cuugaugaga                                                   20


<210>  4736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4736
cacugauucu ccacauggca                                                   20


<210>  4737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4737
ccacauggca ggcggugcuu                                                   20


<210>  4738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4738
uagccuccug cagacaguga                                                   20


<210>  4739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4739
gccacgguau gcugagcuga                                                   20


<210>  4740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4740
aaggcaggga cccugucaau                                                   20


<210>  4741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4741
aucagucugc ucaacacacg                                                   20


<210>  4742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4742
ccucugcagc acacaguagg                                                   20


<210>  4743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4743
cuugagcuua caguucagga                                                   20


<210>  4744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4744
ggaggagaga cugaccagug                                                   20


<210>  4745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4745
ucucucccca aggcugagca                                                   20


<210>  4746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4746
ucgucucucc ccaaggcuga                                                   20


<210>  4747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4747
gcuuggccua cucuccucug                                                   20


<210>  4748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4748
guuugccuuc ugcuuggccu                                                   20


<210>  4749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4749
aacugggcau cauaccagcc                                                   20


<210>  4750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4750
aguccugccc agccccuuau                                                   20


<210>  4751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4751
ccucucugag ccucauuccu                                                   20


<210>  4752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4752
ucuaucugua aaccaguuau                                                   20


<210>  4753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4753
aauuauuaua acugguuuac                                                   20


<210>  4754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4754
uuuaaggacu aaaugagguc                                                   20


<210>  4755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4755
cgaccucauu uaguccuuaa                                                   20


<210>  4756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4756
gcagaugcua gguacggaaa                                                   20


<210>  4757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4757
guaccuagca ucugcugaau                                                   20


<210>  4758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4758
gcgaguuucc guaccuagca                                                   20


<210>  4759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4759
uaaccugccc ccacuucagc                                                   20


<210>  4760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4760
uauccccaga ggcuucuuaa                                                   20


<210>  4761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4761
gaccuaagug guaacagccu                                                   20


<210>  4762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4762
cucuccuuac ccuucagacc                                                   20


<210>  4763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4763
cucugcccag uuggagccgg                                                   20


<210>  4764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4764
ccacaggcag ccucuccucc                                                   20


<210>  4765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4765
ccgcugccau gcgcagggag                                                   20


<210>  4766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4766
agcucacugc aaccucugcc                                                   20


<210>  4767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4767
agcgauucuc cugccucagc                                                   20


<210>  4768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4768
ccugccucag ccucccgagu                                                   20


<210>  4769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4769
ccauguuggc caggcugguc                                                   20


<210>  4770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4770
agaccagccu ggccaacaug                                                   20


<210>  4771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4771
aacuccugcu agugccuccc                                                   20


<210>  4772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4772
aguugggcuc agccaauggg                                                   20


<210>  4773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4773
ccagccugcu cagugcaaac                                                   20


<210>  4774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4774
ccagccuucu ccagccugcu                                                   20


<210>  4775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4775
guuugucccc uagucuauuc                                                   20


<210>  4776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4776
cuccaugucc auccugccca                                                   20


<210>  4777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4777
gaauccuucc uaaaaggaau                                                   20


<210>  4778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4778
gaacuugaca ucuugucugg                                                   20


<210>  4779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4779
uaaaaggaau ccucuaugcc                                                   20


<210>  4780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4780
uuuuaggaag gauucugaac                                                   20


<210>  4781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4781
cgcuccuuga ucaggcuggg                                                   20


<210>  4782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4782
gcaggccuug aaguugcccc                                                   20


<210>  4783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4783
aggccugcag aagccagaga                                                   20


<210>  4784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4784
acgggaugcu cugggcaaag                                                   20


<210>  4785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4785
uccgcccggu accguggagg                                                   20


<210>  4786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4786
gcucagaugg gguggggcag                                                   20


<210>  4787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4787
acuucucggg gggcuuuggg                                                   20


<210>  4788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4788
cggggggcuu ugggacucag                                                   20


<210>  4789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4789
gucccauccc cauccccugc                                                   20


<210>  4790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4790
uguugcccca caaaugcaaa                                                   20


<210>  4791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4791
uucuuuucuc uuguuuuccu                                                   20


<210>  4792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4792
uuucucuugu uuuccuuuuc                                                   20


<210>  4793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4793
cuuguuuucc uuuucucacc                                                   20


<210>  4794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4794
uuuucucacc auuuggaaug                                                   20


<210>  4795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4795
caccauuugg aauggcccag                                                   20


<210>  4796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4796
aaauggugag aaaaggaaaa                                                   20


<210>  4797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4797
aagguaagug cagccugcug                                                   20


<210>  4798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4798
ucugauggug acucuaccua                                                   20


<210>  4799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4799
uguuuugcug cuccaccugc                                                   20


<210>  4800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4800
uggggcuccc ugccugggcc                                                   20


<210>  4801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4801
cucuaggccu uucuuuccac                                                   20


<210>  4802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4802
uuccacuguu cccucugccu                                                   20


<210>  4803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4803
acuguucccu cugccuggug                                                   20


<210>  4804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4804
cucugccugg uguggccugg                                                   20


<210>  4805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4805
auagccaggc cacaccaggc                                                   20


<210>  4806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4806
auggccgcuc cuccucccuc                                                   20


<210>  4807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4807
agcagggacu ugcagguggc                                                   20


<210>  4808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4808
gucggggaag acucuagaug                                                   20


<210>  4809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4809
ccgacugaau ugccaccugc                                                   20


<210>  4810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4810
cuccucaggc caggugcauc                                                   20


<210>  4811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4811
uucucuccuc aggccaggug                                                   20


<210>  4812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4812
aguuggacug uguuaaguuu                                                   20


<210>  4813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4813
ccccaagcuc ugcguccugg                                                   20


<210>  4814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4814
ccccuuaccg guucucgugg                                                   20


<210>  4815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4815
cgugggaucu ugggaagcca                                                   20


<210>  4816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4816
caagauccca cgagaaccgg                                                   20


<210>  4817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4817
ucuaugagcu uugucguucu                                                   20


<210>  4818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4818
augagcuuug ucguucuugu                                                   20


<210>  4819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4819
ugucuguaaa augggcacau                                                   20


<210>  4820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4820
cacagguugc ugugagacuc                                                   20


<210>  4821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4821
acucauugga gucucacagc                                                   20


<210>  4822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4822
aaaagcaucu gcacauccuu                                                   20


<210>  4823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4823
cuuccaaaag caucugcaca                                                   20


<210>  4824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4824
ccacacccag cccaccagcu                                                   20


<210>  4825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4825
gcugcugcca cccuugccag                                                   20


<210>  4826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4826
uacagaggag cuguccucuc                                                   20


<210>  4827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4827
uuuccaacca ggugagaccu                                                   20


<210>  4828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4828
aaccagguga gaccucuuca                                                   20


<210>  4829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4829
guggagcccu ggagcccccu                                                   20


<210>  4830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4830
cagucccugc cuggacuggg                                                   20


<210>  4831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4831
uagcacugcu gugacaaauu                                                   20


<210>  4832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4832
aaccgagggg gugguaauuu                                                   20


<210>  4833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4833
cugcaguccu ggaggccaga                                                   20


<210>  4834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4834
ggccuccagg acugcagaga                                                   20


<210>  4835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4835
ggcuucuggc cuccaggacu                                                   20


<210>  4836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4836
cccggggggc uccagggaga                                                   20


<210>  4837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4837
cccuggagcc ccccgggaga                                                   20


<210>  4838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4838
cuugccucuu ccguguccca                                                   20


<210>  4839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4839
gugucccaac agcggcagca                                                   20


<210>  4840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4840
cacagccuuc ucugugucuc                                                   20


<210>  4841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4841
cugugucucu cuccucuuca                                                   20


<210>  4842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4842
uugucucaua aggacacuug                                                   20


<210>  4843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4843
ccacaugaga ucauccugga                                                   20


<210>  4844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4844
aaauaagguc acagccacag                                                   20


<210>  4845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4845
cuccucuccc uugggccaga                                                   20


<210>  4846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4846
ggcccaaggg agaggaggga                                                   20


<210>  4847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4847
uccccauagg augcccaugg                                                   20


<210>  4848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4848
ccauaggaug cccauggauu                                                   20


<210>  4849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4849
cgcuuccccc gagugucugu                                                   20


<210>  4850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4850
cccgaguguc ugugggaggu                                                   20


<210>  4851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4851
ugccaccucc cacagacacu                                                   20


<210>  4852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4852
acaccccugc cugccauucc                                                   20


<210>  4853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4853
ggagucauau caagggcuug                                                   20


<210>  4854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4854
uccagccaag cccuugauau                                                   20


<210>  4855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4855
ucauucaugg ggaggccaca                                                   20


<210>  4856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4856
uucaugggga ggccacaagc                                                   20


<210>  4857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4857
uggggaggcc acaagcaugg                                                   20


<210>  4858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4858
gguuccucug caaaagggag                                                   20


<210>  4859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4859
ucugcaaaag ggagguaaug                                                   20


<210>  4860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4860
cugucaggua uugagugagg                                                   20


<210>  4861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4861
uuucuuacca uucaauaaua                                                   20


<210>  4862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4862
uaccauucaa uaauaacguu                                                   20


<210>  4863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4863
auaauaacgu uuugagcacc                                                   20


<210>  4864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4864
cauuuguauc cccagcaccu                                                   20


<210>  4865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4865
uucacauuug uauccccagc                                                   20


<210>  4866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4866
uuucauucac auuuguaucc                                                   20


<210>  4867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4867
cccaacagug uauccagaag                                                   20


<210>  4868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4868
ggauacacug uugggggaag                                                   20


<210>  4869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4869
uuaaacaaau gcuacuugac                                                   20


<210>  4870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4870
ggauaggcug agagcucuga                                                   20


<210>  4871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4871
gagcucucag ccuauccaga                                                   20


<210>  4872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4872
gcuggauaca caggcucgca                                                   20


<210>  4873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4873
ugauccuucu gcuggauaca                                                   20


<210>  4874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4874
uggaggaagc gcuguucuag                                                   20


<210>  4875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4875
uccaggaauc cuuuccugau                                                   20


<210>  4876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4876
agccaagacc uacgggggca                                                   20


<210>  4877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4877
acugcuugga caccgucccc                                                   20


<210>  4878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4878
uuccacugcu uggacaccgu                                                   20


<210>  4879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4879
auccacguuc auuccacugc                                                   20


<210>  4880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4880
gcacaggcca cacucccucc                                                   20


<210>  4881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4881
caucugaccu ggaggccacc                                                   20


<210>  4882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4882
uuucacaucu gaccuggagg                                                   20


<210>  4883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4883
uccuuucaca ucugaccugg                                                   20


<210>  4884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4884
caggcguaug gcagggcugc                                                   20


<210>  4885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4885
cucucaccag gcagcccugc                                                   20


<210>  4886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4886
agaggcugga agaggccacu                                                   20


<210>  4887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4887
agccucugga aagcucugug                                                   20


<210>  4888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4888
ugaggccacc uugccacgcu                                                   20


<210>  4889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4889
cugugacagc guggcaaggu                                                   20


<210>  4890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4890
aaacccccgg gugaggcagg                                                   20


<210>  4891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4891
uaggccuccc ucuaucuucc                                                   20


<210>  4892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4892
agccucucac uggaaggaag                                                   20


<210>  4893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4893
agugagaggc uggaaagggg                                                   20


<210>  4894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4894
uuccagugag aggcuggaaa                                                   20


<210>  4895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4895
ugugggggcu uuuaccaggc                                                   20


<210>  4896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4896
ugcccgcuca caccagccca                                                   20


<210>  4897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4897
aagugcaggc gguuccugcc                                                   20


<210>  4898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4898
aucugccgcu ggggccacac                                                   20


<210>  4899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4899
gcugcaagau gaugugacca                                                   20


<210>  4900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4900
ggucccaccc gugcuuggga                                                   20


<210>  4901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4901
cuccucacac acgacgagga                                                   20


<210>  4902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4902
ucgucgugug ugaggaggga                                                   20


<210>  4903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4903
aguccauguu ccucgucgug                                                   20


<210>  4904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4904
gcucgaugug cguugugugg                                                   20


<210>  4905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4905
cucccuggac guaagccaca                                                   20


<210>  4906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4906
agauaagccu guauuccccg                                                   20


<210>  4907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4907
ccgggcuguc ugccaaugua                                                   20


<210>  4908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4908
aggcugacgg gacaacugga                                                   20


<210>  4909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4909
cucagagcuu ccaggcugac                                                   20


<210>  4910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4910
ugagcaccug uauccccugc                                                   20


<210>  4911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4911
acauuccaua gcccagcuca                                                   20


<210>  4912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4912
auagcccagc ucaauaucua                                                   20


<210>  4913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4913
ucuagggugg cgagcacugu                                                   20


<210>  4914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4914
ggucggagcu cacagcgcuc                                                   20


<210>  4915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4915
caguguagca ccgggcacau                                                   20


<210>  4916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4916
cucaucaaua ggcaucuacc                                                   20


<210>  4917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4917
guagcaugcu gagcaggucc                                                   20


<210>  4918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4918
ucuguagcau gcugagcagg                                                   20


<210>  4919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4919
ugccgagacu ggaggccuua                                                   20


<210>  4920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4920
gacugugccc agaccuacua                                                   20


<210>  4921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4921
ggcaaggucg gcccccaguc                                                   20


<210>  4922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4922
ugugggaucu cagagcagcc                                                   20


<210>  4923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4923
guggcugcuc ugagauccca                                                   20


<210>  4924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4924
ccaaauaagg ucuggcucac                                                   20


<210>  4925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4925
cucauaaaga cacaucacag                                                   20


<210>  4926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4926
ccaaucucca ccucugucuc                                                   20


<210>  4927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4927
cuggcuugug gccacauuuc                                                   20


<210>  4928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4928
gguggcugcu gguguucccu                                                   20


<210>  4929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4929
ggcuucuggu ggcugcuggu                                                   20


<210>  4930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4930
ucccagagcc uucgcugcug                                                   20


<210>  4931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4931
cagagccuuc gcugcugagu                                                   20


<210>  4932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4932
cugcugaguc ugggaauuug                                                   20


<210>  4933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4933
cagacucagc agcgaaggcu                                                   20


<210>  4934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4934
gucacaaauu cccagacuca                                                   20


<210>  4935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4935
uauggcuucg gucacaaauu                                                   20


<210>  4936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4936
caucucagga caggugagca                                                   20


<210>  4937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4937
gauggcacuu cagaagacuc                                                   20


<210>  4938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4938
gaagacucag gagacccugg                                                   20


<210>  4939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4939
gaagugccau cugaacagca                                                   20


<210>  4940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4940
accugaggcc cugcuuuucc                                                   20


<210>  4941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4941
uggcugcagg gguuccaggg                                                   20


<210>  4942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4942
agggccaggc cauuuccgcu                                                   20


<210>  4943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4943
gcuggcgcag gacucugcua                                                   20


<210>  4944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4944
ggcagguugc ugcuagcaga                                                   20


<210>  4945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4945
uuuggccugg cugagaguuu                                                   20


<210>  4946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4946
gagaccugcg cuggagcgga                                                   20


<210>  4947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4947
uuccuugcuu ccuuucuucc                                                   20


<210>  4948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4948
uugcuuccuu ucuuccucuc                                                   20


<210>  4949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4949
uuucuuccuc ucucccuucu                                                   20


<210>  4950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4950
uccucucucc cuucuccauc                                                   20


<210>  4951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4951
ucucucccuu cuccauccag                                                   20


<210>  4952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4952
ccauccagca ggcuggaccu                                                   20


<210>  4953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4953
ccuauacccu aaccuuuguc                                                   20


<210>  4954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4954
uggagaaucc aaacugaucc                                                   20


<210>  4955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4955
ccaagaagca ggcacugggg                                                   20


<210>  4956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4956
cugagguugu gacucgugug                                                   20


<210>  4957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4957
gccucacacg agucacaacc                                                   20


<210>  4958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4958
ccacuccaca agauaccagg                                                   20


<210>  4959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4959
ugucucuaaa augagccggc                                                   20


<210>  4960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4960
ccuuugaguc uuuaaaucuu                                                   20


<210>  4961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4961
ugcagacucg gugagcugug                                                   20


<210>  4962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4962
cagcucaccg agucugcaag                                                   20


<210>  4963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4963
aaaaauagua ucaaagugua                                                   20


<210>  4964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4964
uauuauuguu agauauugau                                                   20


<210>  4965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4965
uaugaaggag caggaugacu                                                   20


<210>  4966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4966
uaugaauauc aauaucuaac                                                   20


<210>  4967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4967
uggcaguagc auugccagcu                                                   20


<210>  4968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4968
uugucuauga aauacauuau                                                   20


<210>  4969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4969
uagacaagga aagggaggcc                                                   20


<210>  4970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4970
auaauguauu ucauagacaa                                                   20


<210>  4971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4971
cucguuuaac cuccaaaaaa                                                   20


<210>  4972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4972
ccagugccug ggaugugcuc                                                   20


<210>  4973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4973
guguguuaac uauaagguug                                                   20


<210>  4974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4974
cuccucuccc acaaaugucg                                                   20


<210>  4975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4975
aaggcgacau uugugggaga                                                   20


<210>  4976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4976
cgguggucac ucuguaugcu                                                   20


<210>  4977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4977
agaaugugcc cgaggaggac                                                   20


<210>  4978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4978
cgaagucggu gaccaugacc                                                   20


<210>  4979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4979
acagacaggu aagcacggcc                                                   20


<210>  4980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4980
cacaacugau ggcagggagg                                                   20


<210>  4981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4981
uccauccagc caccugcuga                                                   20


<210>  4982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4982
cauguggucc uuguguucgu                                                   20


<210>  4983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4983
ucgagcaggc cagcaagugu                                                   20


<210>  4984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4984
cuuggcaguu gagcacgcgc                                                   20


<210>  4985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4985
ugguuaggag acauuagcuc                                                   20


<210>  4986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4986
cuggcucugc ggcagaggcu                                                   20


<210>  4987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4987
caguggccac gagugcagau                                                   20


<210>  4988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4988
ucugcacucg uggccacugg                                                   20


<210>  4989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4989
ucaucugcac ucguggccac                                                   20


<210>  4990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4990
gccuugaccc ugggucaaug                                                   20


<210>  4991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4991
acaguuccac acugcucccc                                                   20


<210>  4992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4992
acacugcucc ccuuuuaaaa                                                   20


<210>  4993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4993
auguggaggg acucgaggug                                                   20


<210>  4994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4994
aucuucugcu ugcauaccuc                                                   20


<210>  4995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4995
gcuugcauac cucugagacc                                                   20


<210>  4996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4996
uccaccacau cugccuggcc                                                   20


<210>  4997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4997
agacugugac uacauuuagu                                                   20


<210>  4998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4998
uaggggggcc gcugggugga                                                   20


<210>  4999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  4999
caacuggacu ucauaggggg                                                   20


<210>  5000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5000
cuguccaccg gcccccagag                                                   20


<210>  5001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5001
cucccuuacu gacuuccuuc                                                   20


<210>  5002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5002
uucuguggcc agacauugag                                                   20


<210>  5003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5003
guggccagac auugagcaag                                                   20


<210>  5004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5004
ucaacuauuu agcagcuacg                                                   20


<210>  5005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5005
ccagcuugag cugugcgacc                                                   20


<210>  5006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5006
cagcgaguuc cccagcuuga                                                   20


<210>  5007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5007
acuguaagcc ccagccccca                                                   20


<210>  5008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5008
aaggcugaga aggcccagga                                                   20


<210>  5009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5009
cagccuuuga aacaggcuag                                                   20


<210>  5010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5010
gcccugagac uuuccuacag                                                   20


<210>  5011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5011
uacagaguac agguuuugau                                                   20


<210>  5012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5012
guuuuaaagg caagaaucaa                                                   20


<210>  5013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5013
ugccuuuaaa acugaacauc                                                   20


<210>  5014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5014
gccccaucag gugaccccuu                                                   20


<210>  5015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5015
ugaaggucag uguguggagg                                                   20


<210>  5016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5016
ggaacugacc ugacugagcc                                                   20


<210>  5017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5017
uucccagaaa ggccuucccc                                                   20


<210>  5018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5018
cagaaaggcc uuccccaggc                                                   20


<210>  5019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5019
gggaaagaac agccuccccu                                                   20


<210>  5020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5020
ccaggccugg ugcucuggcc                                                   20


<210>  5021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5021
uggagaaguc ccuucuuugg                                                   20


<210>  5022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5022
ccaggaaguc cuccagaggc                                                   20


<210>  5023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5023
uugggguccc agucagugua                                                   20


<210>  5024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5024
cauacacuga cugggacccc                                                   20


<210>  5025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5025
uugccacugc cauuuccucc                                                   20


<210>  5026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5026
uccucuguaa gcaggugauu                                                   20


<210>  5027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5027
agaccagccu guucaacaug                                                   20


<210>  5028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5028
acauggugaa accccgucuc                                                   20


<210>  5029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5029
ccauguugaa caggcugguc                                                   20


<210>  5030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5030
ccugccuuag ccucccaagu                                                   20


<210>  5031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5031
agcgauucuc cugccuuagc                                                   20


<210>  5032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5032
aucucaaaaa uaaauaagua                                                   20


<210>  5033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5033
ucaccuccac acucagugcc                                                   20


<210>  5034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5034
ccuccacacu cagugccacu                                                   20


<210>  5035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5035
agcuccaucc uuggccacgg                                                   20


<210>  5036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5036
ggauccuggc cucuaagaug                                                   20


<210>  5037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5037
ccccugucaa augaggugug                                                   20


<210>  5038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5038
agguccccuu gcacaucagg                                                   20


<210>  5039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5039
aacccucugc cagccuguga                                                   20


<210>  5040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5040
ccguguuagc aaggaugguc                                                   20


<210>  5041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5041
ccugccucag ccuccugagu                                                   20


<210>  5042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5042
cgccauucuc cugccucagc                                                   20


<210>  5043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5043
agacggaguc ucgcucuauu                                                   20


<210>  5044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5044
uuccagacgg agucucgcuc                                                   20


<210>  5045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5045
ggccucagug gcacuccacu                                                   20


<210>  5046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5046
uucuggccuc aguggcacuc                                                   20


<210>  5047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5047
uuagacaauc cugggagcaa                                                   20


<210>  5048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5048
cagagggcgg ggccacacag                                                   20


<210>  5049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5049
aguuugugug gguccaacac                                                   20


<210>  5050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5050
cccgccacuc ucugaggccu                                                   20


<210>  5051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5051
ccacccaacu ucccccgcca                                                   20


<210>  5052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5052
cauuccucug aggcucaucc                                                   20


<210>  5053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5053
ucugaggcuc auccucuugg                                                   20


<210>  5054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5054
uggaaaggga uaauaagguu                                                   20


<210>  5055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5055
augaaagaga ggcaccaaga                                                   20


<210>  5056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5056
uauauucaga cgcuuagaca                                                   20


<210>  5057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5057
gacgcuuaga cagagccagg                                                   20


<210>  5058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5058
cugugccugg cucugucuaa                                                   20


<210>  5059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5059
aguuuguauu ggucaagguu                                                   20


<210>  5060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5060
gcagagaagc agaaccagua                                                   20


<210>  5061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5061
cugcagaacc uugaccaaua                                                   20


<210>  5062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5062
gcuucucugc agaaccuuga                                                   20


<210>  5063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5063
agcucaugug accgugcggg                                                   20


<210>  5064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5064
gacuugccag cccgcacggu                                                   20


<210>  5065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5065
ugcagaauuu gauguugcaa                                                   20


<210>  5066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5066
gcaggaauug ccagccugcc                                                   20


<210>  5067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5067
gccccaggac ugccuuagga                                                   20


<210>  5068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5068
uucuucccug ggaggccuca                                                   20


<210>  5069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5069
ucccugggag gccucagucu                                                   20


<210>  5070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5070
cugggaggcc ucagucuguu                                                   20


<210>  5071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5071
cuuaaggccu ucaacugauu                                                   20


<210>  5072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5072
acugauuaaa ugaggccugc                                                   20


<210>  5073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5073
gauuuaaaug uuagucacau                                                   20


<210>  5074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5074
cagcagcauu uccacuggcu                                                   20


<210>  5075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5075
acuggcuuuu gaccaaacau                                                   20


<210>  5076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5076
cagccccucc cuuacaggca                                                   20


<210>  5077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5077
ucccaggccu ggaguuuauu                                                   20


<210>  5078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5078
gaaaagccag cugguccagc                                                   20


<210>  5079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5079
gaauaaacuc caggccuggg                                                   20


<210>  5080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5080
gggacgaugc cugccucuac                                                   20


<210>  5081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5081
uguggcacgu gggcuucuug                                                   20


<210>  5082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5082
uguggcacgu uccuggaggc                                                   20


<210>  5083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5083
uggaggccga acccuucugg                                                   20


<210>  5084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5084
gccuccagga acgugccaca                                                   20


<210>  5085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5085
ggcuuuggaa ggagucguca                                                   20


<210>  5086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5086
aaagccagaa ggguucggcc                                                   20


<210>  5087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5087
uccccagccu cccgcauggc                                                   20


<210>  5088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5088
agccccuucc uccccagccu                                                   20


<210>  5089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5089
gacucugcga ugauggaggu                                                   20


<210>  5090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5090
ggagggagag uggccaggac                                                   20


<210>  5091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5091
gguacccgcc cccuccccau                                                   20


<210>  5092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5092
cauuagccuu gcucaaguug                                                   20


<210>  5093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5093
ucgggugaga ggucugagcc                                                   20


<210>  5094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5094
ccuagauacc cgcagugucc                                                   20


<210>  5095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5095
uuccccuaga uacccgcagu                                                   20


<210>  5096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5096
acuucaaguc uggaacuuca                                                   20


<210>  5097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5097
agucuggaac uucaagucug                                                   20


<210>  5098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5098
agacuugaag uggaacaaga                                                   20


<210>  5099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5099
agucugugug ugugcgugcg                                                   20


<210>  5100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5100
cuggcggccg aauuuaaagg                                                   20


<210>  5101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5101
gccgccaggg aagccuugau                                                   20


<210>  5102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5102
ccccguggca cuuagaacca                                                   20


<210>  5103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5103
aagugccacg gggggaaacu                                                   20


<210>  5104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5104
guguaucaag ugguucuaag                                                   20


<210>  5105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5105
uaucuccccc acuaggaugu                                                   20


<210>  5106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5106
caaugccccu guggaguuua                                                   20


<210>  5107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5107
gccugggcag ucagauuuuc                                                   20


<210>  5108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5108
uuaggagggg acauuugagu                                                   20


<210>  5109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5109
cugccaccca ccuccucacc                                                   20


<210>  5110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5110
aggucaucac aguuggggcc                                                   20


<210>  5111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5111
ucucuggucc cccugcacag                                                   20


<210>  5112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5112
aggacacuca gucugaugag                                                   20


<210>  5113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5113
ucugugcacu cgccucccuc                                                   20


<210>  5114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5114
cugacccucg ggcugggcag                                                   20


<210>  5115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5115
uccaucaagc ucccgaucaa                                                   20


<210>  5116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5116
ccuggccgau aagacagcaa                                                   20


<210>  5117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5117
agaagagagc uuagugucug                                                   20


<210>  5118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5118
cgaagguaag ccgccugcag                                                   20


<210>  5119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5119
ccauucaccc cugcaccagg                                                   20


<210>  5120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5120
ccccugcacc aggcauugca                                                   20


<210>  5121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5121
cugccaaaga ugucaucaau                                                   20


<210>  5122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5122
cugaggacca gcggguacug                                                   20


<210>  5123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5123
cccuugucug uguaaggagg                                                   20


<210>  5124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5124
cauuuaaucc uauuuaaggu                                                   20


<210>  5125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5125
gagccccauu cucauuuaau                                                   20


<210>  5126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5126
uaacguguuu uuauagagac                                                   20


<210>  5127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5127
uuaagcccuc cucucuccua                                                   20


<210>  5128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5128
ugguaggaga gaggagggcu                                                   20


<210>  5129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5129
guggaggucc ccucacuccc                                                   20


<210>  5130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5130
ccaggagugg gaagcggcgg                                                   20


<210>  5131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5131
cacuccugga gaaacuggag                                                   20


<210>  5132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5132
ugugugugug ugugugugug                                                   20


<210>  5133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5133
guaagcuuac agggcuggcc                                                   20


<210>  5134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5134
cgcggcuggg ggcugcugga                                                   20


<210>  5135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5135
cgcuguggcu cucuccagca                                                   20


<210>  5136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5136
uagaggcugc aggacagugc                                                   20


<210>  5137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5137
augcucaccu gggugugagc                                                   20


<210>  5138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5138
gggagcugag aaaucucaaa                                                   20


<210>  5139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5139
cagcucccag aaccauggag                                                   20


<210>  5140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5140
acuuuuuugc ugguuugaga                                                   20


<210>  5141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5141
accaaaaugc ugcaaccaga                                                   20


<210>  5142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5142
ggcuugagga gauggggucu                                                   20


<210>  5143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5143
cucuaucucc auuuugaaac                                                   20


<210>  5144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5144
aaauggagau agagagaaau                                                   20


<210>  5145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5145
aaacacagag ugguuucaaa                                                   20


<210>  5146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5146
uccaaacaca gagugguuuc                                                   20


<210>  5147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5147
gagcugccca cuggcagaac                                                   20


<210>  5148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5148
gccagugggc agcucugaau                                                   20


<210>  5149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5149
uugggcagga gugagcuccu                                                   20


<210>  5150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5150
ggggacaagg agcucacucc                                                   20


<210>  5151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5151
guguuuucaa agcccauucu                                                   20


<210>  5152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5152
aagcccauuc uaaagcagau                                                   20


<210>  5153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5153
aaagcagauu cccauuuccg                                                   20


<210>  5154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5154
cauuuccguc uuugacucua                                                   20


<210>  5155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5155
gucuuugacu cuaaggccca                                                   20


<210>  5156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5156
ccuuaugcac ccacugcccg                                                   20


<210>  5157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5157
auacucuggu ucugccacuu                                                   20


<210>  5158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5158
gccacuucca ugcccuuuga                                                   20


<210>  5159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5159
augcccuuug agccugggca                                                   20


<210>  5160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5160
ccucaucuca gcuuccuccu                                                   20


<210>  5161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5161
uccuccauaa gagggaaaaa                                                   20


<210>  5162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5162
cucuuaugga ggaggaagcu                                                   20


<210>  5163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5163
gccccagccg ggggccucuc                                                   20


<210>  5164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5164
aaccgagguc ugcccuccuu                                                   20


<210>  5165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5165
cccugccgcu cuauagcugu                                                   20


<210>  5166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5166
ucauacagag auguuaagua                                                   20


<210>  5167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5167
agcuaucguu acuauuguuu                                                   20


<210>  5168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5168
ucacccguug cuuuaaaauc                                                   20


<210>  5169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5169
acacagggua gcccgucaau                                                   20


<210>  5170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5170
ugcuaccugc cugggcaugu                                                   20


<210>  5171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5171
gguugggugg agcaugagag                                                   20


<210>  5172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5172
cagaccucuc augcuccacc                                                   20


<210>  5173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5173
aggcuggagu cccacugucu                                                   20


<210>  5174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5174
cgucugagca cguccagggg                                                   20


<210>  5175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5175
ccuggacgug cucagacgag                                                   20


<210>  5176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5176
caaacccuca gugguucccc                                                   20


<210>  5177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5177
cacccucacu cuccuguucc                                                   20


<210>  5178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5178
gggcacagca ggcuggcaug                                                   20


<210>  5179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5179
ggaaagauga gcauagucag                                                   20


<210>  5180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5180
ugaacaucca uccuacaugc                                                   20


<210>  5181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5181
gggguccugg cuuggaggga                                                   20


<210>  5182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5182
cuccaagcca ggaccccuga                                                   20


<210>  5183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5183
aaaggggagc gugauuagag                                                   20


<210>  5184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5184
aacugacaug ugccugugag                                                   20


<210>  5185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5185
augacuucaa acugacaugu                                                   20


<210>  5186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5186
uggagucaga uuccaugacu                                                   20


<210>  5187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5187
cuuagcugca aaauggugcu                                                   20


<210>  5188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5188
cuauguccua gcugcaaggg                                                   20


<210>  5189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5189
gagcacaugc caggcuccau                                                   20


<210>  5190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5190
cacgugucau cuucacagug                                                   20


<210>  5191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5191
cagugucccu gugaguaggu                                                   20


<210>  5192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5192
cuuuccaucu uacaaaugag                                                   20


<210>  5193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5193
aucuuacaaa ugaguaaaca                                                   20


<210>  5194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5194
uagccaaugg gugugucuga                                                   20


<210>  5195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5195
gaggugguuc agacagaccc                                                   20


<210>  5196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5196
gacagacccc ggcuuacccu                                                   20


<210>  5197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5197
aggguaagcc ggggucuguc                                                   20


<210>  5198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5198
gccugcuggc ugcauaggga                                                   20


<210>  5199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5199
acccagagau ggagacagug                                                   20


<210>  5200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5200
cugagaaacu aaggcucaga                                                   20


<210>  5201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5201
cagggaaaac accaucuuuc                                                   20


<210>  5202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5202
accucucuga gccuuaguuu                                                   20


<210>  5203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5203
caacucugca gcugaccagc                                                   20


<210>  5204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5204
uugaguuguu ucuagguuuc                                                   20


<210>  5205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5205
agguuuccua gcucuugccu                                                   20


<210>  5206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5206
uagcucuugc cucagaccuu                                                   20


<210>  5207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5207
caucugagcu ggcuuuccuc                                                   20


<210>  5208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5208
ucugccccag gcugcagcuc                                                   20


<210>  5209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5209
ugcugccaug ccccaggucu                                                   20


<210>  5210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5210
agaccugggg cauggcagca                                                   20


<210>  5211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5211
augcuccuug acuuugcauu                                                   20


<210>  5212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5212
ccugcuccug aggggccggg                                                   20


<210>  5213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5213
gugucaguuu gugccaccac                                                   20


<210>  5214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5214
gccauugugu ggacagcaug                                                   20


<210>  5215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5215
acuccaagug gaguggggua                                                   20


<210>  5216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5216
uuaugccaua uuuaugcaca                                                   20


<210>  5217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5217
gagauggggu cuugcugugu                                                   20


<210>  5218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5218
ugggcucaag caauccucug                                                   20


<210>  5219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5219
gcaugcagcu caggcacccc                                                   20


<210>  5220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5220
ugccuugcug gucaugcuaa                                                   20


<210>  5221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5221
agggcuuggc acaugccuug                                                   20


<210>  5222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5222
agaaaccuga guguauaacu                                                   20


<210>  5223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5223
agaaggcccg gcugucacau                                                   20


<210>  5224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5224
uuuaagagug gacuccuuag                                                   20


<210>  5225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5225
ggucuggaug gugcauuccu                                                   20


<210>  5226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5226
ucgagagcaa aagacagucu                                                   20


<210>  5227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5227
aggugcucuu ccuggcacug                                                   20


<210>  5228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5228
uggcacuggg gagggauaca                                                   20


<210>  5229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5229
cccuccugga gcaucuauuu                                                   20


<210>  5230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5230
uccacuaaaa uagaugcucc                                                   20


<210>  5231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5231
gucuuccucc acuaaaauag                                                   20


<210>  5232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5232
guacucuaua uuaaugguuu                                                   20


<210>  5233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5233
ccaucgcauc uuuucaguac                                                   20


<210>  5234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5234
uugcuauagu uuucuccauc                                                   20


<210>  5235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5235
cuuccuugcu auaguuuucu                                                   20


<210>  5236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5236
uccaccuugu cagcgagacc                                                   20


<210>  5237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5237
cugccucaug gccuguuucg                                                   20


<210>  5238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5238
aggcaaagca aaggccccca                                                   20


<210>  5239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5239
ugguacuccc ugcacauccc                                                   20


<210>  5240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5240
caccucucug guuuccuggu                                                   20


<210>  5241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5241
gauccaggcc agaccacacu                                                   20


<210>  5242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5242
cagcucagca gcuaggccac                                                   20


<210>  5243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5243
gcccaagguc cuugucaucu                                                   20


<210>  5244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5244
gacuccagcc ugagccccgc                                                   20


<210>  5245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5245
gagggaugag uuuggcacug                                                   20


<210>  5246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5246
ugccugguuu gagggccgug                                                   20


<210>  5247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5247
gcaccauggc ugaccaaaca                                                   20


<210>  5248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5248
gugaggccaa agugcagacg                                                   20


<210>  5249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5249
cccuccgaca uccuucugug                                                   20


<210>  5250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5250
uuucucccuc cgacauccuu                                                   20


<210>  5251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5251
uuuccucggg cucuggcagg                                                   20


<210>  5252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5252
ucgggcucug gcaggugacc                                                   20


<210>  5253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5253
cuggugcugc cuguagugcu                                                   20


<210>  5254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5254
gacuuguccc ucucucagcc                                                   20


<210>  5255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5255
gccuuuccgg ggcugcuggc                                                   20


<210>  5256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5256
ggggcugcug gccuggcccu                                                   20


<210>  5257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5257
aggcaaggag gcugccccac                                                   20


<210>  5258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5258
uggcaccucc accuggggag                                                   20


<210>  5259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5259
ccauucaaac aggucgagcu                                                   20


<210>  5260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5260
aacaggucga gcugugcucg                                                   20


<210>  5261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5261
gcccacggac aucggcacau                                                   20


<210>  5262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5262
gugccaggca uucaauccuc                                                   20


<210>  5263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5263
auccucaggu cuccaccaag                                                   20


<210>  5264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5264
ucccauggau aggggagggg                                                   20


<210>  5265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5265
cauggauagg ggagggggcg                                                   20


<210>  5266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5266
cacucacccc ccaacgaugu                                                   20


<210>  5267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5267
ccacaguuag cuggagauga                                                   20


<210>  5268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5268
ggauggcauc uagccagagg                                                   20


<210>  5269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5269
ugagccaccu uuacucugcu                                                   20


<210>  5270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5270
caccccuacu ucacagagga                                                   20


<210>  5271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5271
cagaggaaga aaccuggaac                                                   20


<210>  5272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5272
ucugugaagu aggggugcga                                                   20


<210>  5273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5273
uccucuguga aguaggggug                                                   20


<210>  5274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5274
agguuucuuc cucugugaag                                                   20


<210>  5275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5275
ugcuguguga gcuuggcagg                                                   20


<210>  5276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5276
ggcucaguuc cugcugugug                                                   20


<210>  5277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5277
gagccagccc aaucugcguu                                                   20


<210>  5278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5278
uacuucaccc ggcugggcuc                                                   20


<210>  5279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5279
cccggcuggg cuccucauuu                                                   20


<210>  5280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5280
cagccucacu guuacccgua                                                   20


<210>  5281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5281
ccuucccagc cucacuguua                                                   20


<210>  5282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5282
uggucugugu uccccuuccc                                                   20


<210>  5283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5283
gccaucacuc accgagcuuc                                                   20


<210>  5284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5284
augccugcag gcaucguucu                                                   20


<210>  5285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5285
guuaucaccc aggccugauu                                                   20


<210>  5286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5286
cuggccuggc ggagaugcuu                                                   20


<210>  5287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5287
aaggcauggu cgggggagag                                                   20


<210>  5288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5288
agaccuguuu ugcuuuugua                                                   20


<210>  5289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5289
aguuacaaaa gcaaaacagg                                                   20


<210>  5290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5290
ggguuuugua gcauuuuuau                                                   20


<210>  5291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5291
uaguauaagc aaggcaucac                                                   20


<210>  5292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5292
acaaacuuac ccaguuccua                                                   20


<210>  5293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5293
caucaccagu acuugcccaa                                                   20


<210>  5294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5294
uaggauaggc acaaggagua                                                   20


<210>  5295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5295
uuccuaggau aggcacaagg                                                   20


<210>  5296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5296
uuucauuccu aggauaggca                                                   20


<210>  5297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5297
ugcagcuccc cugaccaccc                                                   20


<210>  5298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5298
uucuuuucuc cccaguaccu                                                   20


<210>  5299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5299
uuucucccca guaccuggca                                                   20


<210>  5300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5300
ccccaguacc uggcacacag                                                   20


<210>  5301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5301
guaaauacuc gggccaggcu                                                   20


<210>  5302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5302
guaaugagcc agugcuaagu                                                   20


<210>  5303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5303
ugauuuaaaa uucagaacag                                                   20


<210>  5304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5304
gaacagucuc agauugggug                                                   20


<210>  5305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5305
gaauuuuaaa ucaugaaaaa                                                   20


<210>  5306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5306
uaaacacaag caauccuccu                                                   20


<210>  5307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5307
agacccuggg caacagugag                                                   20


<210>  5308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5308
augugggacc uccaggcccu                                                   20


<210>  5309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5309
ccagccuuag aguggagggc                                                   20


<210>  5310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5310
cucucucucu agacagccca                                                   20


<210>  5311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5311
uuaugacaug ggcugucuag                                                   20


<210>  5312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5312
ucccagauua cauuuucuga                                                   20


<210>  5313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5313
gacaauucag ugucauauau                                                   20


<210>  5314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5314
gugucauaua uggaaagcau                                                   20


<210>  5315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5315
auauaugaca cugaauuguc                                                   20


<210>  5316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5316
agaguugaca gauggcaaug                                                   20


<210>  5317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5317
agccauugcc aucugucaac                                                   20


<210>  5318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5318
aacgggcaga gauaacacag                                                   20


<210>  5319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5319
ccuccacaga aucaaguauc                                                   20


<210>  5320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5320
guggagggga aggagagaga                                                   20


<210>  5321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5321
aacaucacag agcugucagg                                                   20


<210>  5322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5322
ugcagagggu uagcaggugg                                                   20


<210>  5323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5323
uccccgaucc cuggugacca                                                   20


<210>  5324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5324
ugcaagccac accccuuccu                                                   20


<210>  5325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5325
ccuuccugca agccacaccc                                                   20


<210>  5326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5326
cuauuugcua guccagauuu                                                   20


<210>  5327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5327
uaguggccag cguugcucac                                                   20


<210>  5328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5328
ugcuagaucc cacaggucuc                                                   20


<210>  5329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5329
ucuccaccaa agcuuuuggc                                                   20


<210>  5330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5330
gcauccuccu cuaagcuuug                                                   20


<210>  5331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5331
ucugcaaagc uuagaggagg                                                   20


<210>  5332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5332
ggauucaucu gcaaagcuua                                                   20


<210>  5333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5333
cuggaggggc ugaccauuuc                                                   20


<210>  5334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5334
uuucucugga ggggcugacc                                                   20


<210>  5335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5335
ucuuaguacu uuacacuaau                                                   20


<210>  5336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5336
cccgcccacu acggcugugu                                                   20


<210>  5337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5337
gauauaugaa gaauggcggc                                                   20


<210>  5338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5338
uauaucagaa cacagccgua                                                   20


<210>  5339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5339
ucauauauca gaacacagcc                                                   20


<210>  5340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5340
aaaacagagu uggagucuug                                                   20


<210>  5341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5341
aagaguauaa aauaaauuuu                                                   20


<210>  5342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5342
uagcuucuaa gaguauaaaa                                                   20


<210>  5343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5343
uguguggcaa aguucuuagc                                                   20


<210>  5344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5344
aaauuugguu cauguguggc                                                   20


<210>  5345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5345
ucccuagugu aucuacuucc                                                   20


<210>  5346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5346
cuaguguauc uacuuccuuu                                                   20


<210>  5347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5347
uuuugaaauu uuauaaacaa                                                   20


<210>  5348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5348
aaaggaagua gauacacuag                                                   20


<210>  5349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5349
ucugcuaccu cuuguguaua                                                   20


<210>  5350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5350
agucugcuug uuccaagcuc                                                   20


<210>  5351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5351
aagcucagaa gguaacugca                                                   20


<210>  5352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5352
gagcuuggaa caagcagacu                                                   20


<210>  5353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5353
cugcuaacau cgaggugugu                                                   20


<210>  5354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5354
uaaaacugac uguaguuguc                                                   20


<210>  5355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5355
ccuggagucc ucacacgguc                                                   20


<210>  5356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5356
uucccaggau gccuucaacg                                                   20


<210>  5357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5357
caggaugccu ucaacgggca                                                   20


<210>  5358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5358
acgggcagaa ucggccaucu                                                   20


<210>  5359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5359
gcccguugaa ggcauccugg                                                   20


<210>  5360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5360
ugagaacaca cagcauuauu                                                   20


<210>  5361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5361
caagaagcuc ccuuagugag                                                   20


<210>  5362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5362
ugcucuguuu gcagaccauu                                                   20


<210>  5363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5363
aaauggucug caaacagagc                                                   20


<210>  5364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5364
uccaaaaaau uggcaguaaa                                                   20


<210>  5365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5365
aagguaagcc ugucauaacu                                                   20


<210>  5366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5366
uugacuguag cugucagcaa                                                   20


<210>  5367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5367
cuuugcuggu aaccacuuga                                                   20


<210>  5368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5368
gaucauguug cuuauauugu                                                   20


<210>  5369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5369
ucaggaucgu ccaccgugua                                                   20


<210>  5370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5370
gcaccccuag caccugccgu                                                   20


<210>  5371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5371
auaggaaaua aggggacuag                                                   20


<210>  5372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5372
uauggaaaca acgccuuccg                                                   20


<210>  5373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5373
aguccccuua uuuccuaugg                                                   20


<210>  5374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5374
cuccugauuu ugggcuccug                                                   20


<210>  5375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5375
aggucauguc ccacacaauc                                                   20


<210>  5376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5376
cuccgcccac auccucacca                                                   20


<210>  5377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5377
caccuucucu ccgcccacau                                                   20


<210>  5378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5378
ccuacccuau ucucaccuuc                                                   20


<210>  5379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5379
uguccuacug uuuccccuac                                                   20


<210>  5380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5380
cguacucaaa accaauggua                                                   20


<210>  5381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5381
accauugguu uugaguacgu                                                   20


<210>  5382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5382
aacugcaaga ccauuggaac                                                   20


<210>  5383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5383
aauggucuug caguuugaaa                                                   20


<210>  5384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5384
gacgguucca auggucuugc                                                   20


<210>  5385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5385
cuaaggguac aguucugcuc                                                   20


<210>  5386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5386
gcucuuaagu gcuggcccuu                                                   20


<210>  5387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5387
aucuucucag uguguuugac                                                   20


<210>  5388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5388
caguguguuu gacaaaggcc                                                   20


<210>  5389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5389
gugacuugcu ggagguuggc                                                   20


<210>  5390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5390
uuguuauucu gugacuugcu                                                   20


<210>  5391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5391
gugcugucag acuucauugu                                                   20


<210>  5392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5392
cuggcaguga ggguuucugu                                                   20


<210>  5393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5393
uucucuggca gugaggguuu                                                   20


<210>  5394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5394
gggcuggcug cgccucugug                                                   20


<210>  5395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5395
cugucagauu ugccaaguca                                                   20


<210>  5396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5396
uaaggcuccc uaguucugug                                                   20


<210>  5397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5397
gugcauggug agaugaaaau                                                   20


<210>  5398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5398
ucucaccaug cacagaacua                                                   20


<210>  5399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5399
gcccuguuuu gccuuuaguu                                                   20


<210>  5400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5400
aaauacaaaa uguacaaaau                                                   20


<210>  5401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5401
uauauauuuu guacauuuug                                                   20


<210>  5402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5402
cucauuuaua ccagcucccu                                                   20


<210>  5403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5403
aaaguauagc accauucacu                                                   20


<210>  5404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5404
auugcuuuau auuuauuucu                                                   20


<210>  5405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5405
gggaaaauaa aucuuaaacc                                                   20


<210>  5406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5406
cagaaauaaa uauaaagcaa                                                   20


<210>  5407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5407
guguuaauua gucauguuga                                                   20


<210>  5408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5408
ccucaacaug acuaauuaac                                                   20


<210>  5409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5409
caaauuccuu cucugcauua                                                   20


<210>  5410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5410
uucucugcau uacaauaacu                                                   20


<210>  5411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5411
cugcauuaca auaacuauga                                                   20


<210>  5412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5412
uaguuauugu aaugcagaga                                                   20


<210>  5413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5413
uauacaacca auaccaaggg                                                   20


<210>  5414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5414
guaauuaugu uuuaagcaaa                                                   20


<210>  5415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5415
auaugucucc aagcauuaaa                                                   20


<210>  5416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5416
gugaaguuaa acucaguaaa                                                   20


<210>  5417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5417
cagaauuauc uuuuuaaugc                                                   20


<210>  5418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5418
ccaaacagau uuuaaaaaca                                                   20


<210>  5419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5419
uuaaguaauu gaugucaaau                                                   20


<210>  5420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5420
ggagaacaca gcauuuucaa                                                   20


<210>  5421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5421
ccagaaguac agggugcauu                                                   20


<210>  5422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5422
aaauugcucu uuucaaucua                                                   20


<210>  5423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5423
aucuaauuau aucagaaaaa                                                   20


<210>  5424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5424
gauauaauua gauugaaaag                                                   20


<210>  5425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5425
agagcuuagu auuucccaau                                                   20


<210>  5426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5426
caauuuuuga uccugauccu                                                   20


<210>  5427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5427
ucaagaucca agcuuaugca                                                   20


<210>  5428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5428
caucuagacc caucugaaau                                                   20


<210>  5429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5429
gaugggucua gaugagaacc                                                   20


<210>  5430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5430
auacaaauag ggagacauau                                                   20


<210>  5431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5431
uuguaaaaua guaauuaagu                                                   20


<210>  5432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5432
uuuucauugu aaaauaguaa                                                   20


<210>  5433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5433
uguuuaauau uacugcaaga                                                   20


<210>  5434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5434
uaaaauauaa aaaccaaagg                                                   20


<210>  5435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5435
uuugguuuuu auauuuuaag                                                   20


<210>  5436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5436
uuuguagcau cguagagaaa                                                   20


<210>  5437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5437
cuacgaugcu acaaaagaaa                                                   20


<210>  5438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5438
uguaacaaaa aagucugcca                                                   20


<210>  5439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5439
gaaaaucucc acagaaaugu                                                   20


<210>  5440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5440
gaaauagagc caguggcaga                                                   20


<210>  5441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5441
guggagauuu ucggaaauag                                                   20


<210>  5442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5442
cauuucugug gagauuuucg                                                   20


<210>  5443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5443
cccacugcca aacagcuccc                                                   20


<210>  5444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5444
aguggcuuaa aaaugcuuuc                                                   20


<210>  5445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5445
uugagaaaua cacgauccgc                                                   20


<210>  5446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5446
caaggaaagc auuuuuaagc                                                   20


<210>  5447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5447
caguccaauc uccaggcucu                                                   20


<210>  5448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5448
aaaggguucg agauucugau                                                   20


<210>  5449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5449
agauucugau uccaagaagg                                                   20


<210>  5450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5450
gauuccaaga aggugcugag                                                   20


<210>  5451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5451
aagaaggugc ugagcaucca                                                   20


<210>  5452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5452
uggaaucaga aucucgaacc                                                   20


<210>  5453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5453
ucuagggauc aacaucauca                                                   20


<210>  5454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5454
caacucacca aucaucaugg                                                   20


<210>  5455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5455
gaacccugca gaaaagaaaa                                                   20


<210>  5456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5456
gaaucuccca ugaugauugg                                                   20


<210>  5457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5457
gcaggguuca gaaucuccca                                                   20


<210>  5458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5458
uuucugcagg guucagaauc                                                   20


<210>  5459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5459
uuuucuuuuc ugcaggguuc                                                   20


<210>  5460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5460
uacgguuaga gaaaagguuu                                                   20


<210>  5461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5461
cuaaccguau gaacuuuaac                                                   20


<210>  5462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5462
augcugacuu guguucugca                                                   20


<210>  5463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5463
gcaauuuaaa caugucuuca                                                   20


<210>  5464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5464
ucuggcaacu uaaugcaaug                                                   20


<210>  5465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5465
ugauuaugua aaacauguac                                                   20


<210>  5466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5466
augaucucau uuagucagug                                                   20


<210>  5467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5467
cugacuaaau gagaucauag                                                   20


<210>  5468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5468
cacaugggug cagaguagca                                                   20


<210>  5469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5469
cguugggcac ugugugagcc                                                   20


<210>  5470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5470
gacccaggag ugacccagag                                                   20


<210>  5471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5471
ccaagugugu aagccaaagg                                                   20


<210>  5472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5472
gaauacucac cgugugccau                                                   20


<210>  5473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5473
gaacgauucg ccaagugugu                                                   20


<210>  5474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5474
accucagggc cccccuacuc                                                   20


<210>  5475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5475
uuccaccuca gggccccccu                                                   20


<210>  5476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5476
gaaaaugggc caggcacagu                                                   20


<210>  5477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5477
gaauuuuauu uaucaaaugu                                                   20


<210>  5478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5478
ccuugccuca gccucccaag                                                   20


<210>  5479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5479
agcgauucuc cuugccucag                                                   20


<210>  5480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5480
cccagguucc agcgauucuc                                                   20


<210>  5481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5481
gauuuuuuuu uuuuuuuuuu                                                   20


<210>  5482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5482
ggcuuuucuc cucauacaaa                                                   20


<210>  5483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5483
ccucauacaa agccuuugaa                                                   20


<210>  5484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5484
aaggcuuugu augaggagaa                                                   20


<210>  5485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5485
ugcacuaaaa ccuuucaaag                                                   20


<210>  5486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5486
cucugguuca ugcacuaaaa                                                   20


<210>  5487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5487
aagggagcug uccgggauga                                                   20


<210>  5488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5488
uuaucucaca cacagcaccc                                                   20


<210>  5489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5489
ccacuuggca uaccuuaaag                                                   20


<210>  5490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5490
ugacguucuc cacuuggcau                                                   20


<210>  5491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5491
uguucagaaa uccaaggugg                                                   20


<210>  5492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5492
gaaauccaag gugggugcgg                                                   20


<210>  5493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5493
gaacaugaac auccagcucu                                                   20


<210>  5494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5494
cuccgcaccc accuuggauu                                                   20


<210>  5495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5495
ggaccaccag uaaagguuug                                                   20


<210>  5496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5496
uaguacugcc ucuucuggac                                                   20


<210>  5497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5497
cugucuccuu ccuaguacug                                                   20


<210>  5498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5498
uucucugucu ccuuccuagu                                                   20


<210>  5499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5499
ggcuguuccu ucucugucuc                                                   20


<210>  5500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5500
ucaaacccuu cuggcuguuc                                                   20


<210>  5501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5501
cucucguagu uuuccucaaa                                                   20


<210>  5502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5502
ugacacuucu cucucguagu                                                   20


<210>  5503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5503
agggcuuucc ugacacuucu                                                   20


<210>  5504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5504
aacgggaaga gcgccaggag                                                   20


<210>  5505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5505
cguuugaaac acuauuccag                                                   20


<210>  5506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5506
ggccucaucu uagccgacug                                                   20


<210>  5507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5507
cuccaacuca gcaguugggg                                                   20


<210>  5508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5508
cugcuaacuc ccucuucucu                                                   20


<210>  5509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5509
gccucuuccc ugcuaacucc                                                   20


<210>  5510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5510
uaucucucac ucgcucuuca                                                   20


<210>  5511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5511
ccauuuucuu aucucucacu                                                   20


<210>  5512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5512
cuaaacuuaa cuuuccccau                                                   20


<210>  5513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5513
acuaauucuc uaaacuuaac                                                   20


<210>  5514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5514
uugcagccaa acuucgacua                                                   20


<210>  5515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5515
cuucuuugca gccaaacuuc                                                   20


<210>  5516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5516
uuucucuucu uugcagccaa                                                   20


<210>  5517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5517
cccuguugcc ccugccuucu                                                   20


<210>  5518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5518
gcccugucaa agccucucuu                                                   20


<210>  5519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5519
gcccugucaa agccucucuu                                                   20


<210>  5520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5520
cuucugcccu gucaaagccu                                                   20


<210>  5521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5521
cagcgacguc ucagcacacu                                                   20


<210>  5522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5522
ggauauugaa gaguuacaua                                                   20


<210>  5523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5523
auauccagaa cgcuccaccc                                                   20


<210>  5524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5524
aauguguaug uaacucuuca                                                   20


<210>  5525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5525
cacugucaca ggagaggaga                                                   20


<210>  5526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5526
ugucuccucu ccugugacag                                                   20


<210>  5527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5527
caagcaucug cacuguucuu                                                   20


<210>  5528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5528
cugcaaauga aguaggugau                                                   20


<210>  5529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5529
uuugcagaga aaauaaaagc                                                   20


<210>  5530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5530
guaaaaucag ggugacagcu                                                   20


<210>  5531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5531
gauccucaua agcacuaugu                                                   20


<210>  5532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5532
uuuaaugggg ccuauucugu                                                   20


<210>  5533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5533
guaccaagua cugugaaggg                                                   20


<210>  5534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5534
caguacuugg uacagaauag                                                   20


<210>  5535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5535
uuaacagcag ucuccucugu                                                   20


<210>  5536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5536
aauagucugu aacuuuccuu                                                   20


<210>  5537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5537
guguuugcac acagugggug                                                   20


<210>  5538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5538
auacauauuu auuuucuuuu                                                   20


<210>  5539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5539
uuuucuacua uaaugauugg                                                   20


<210>  5540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5540
acuauaauga uugguauuaa                                                   20


<210>  5541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5541
uuuuuuaaaa auacauguca                                                   20


<210>  5542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5542
uggacucccc uggcaagcag                                                   20


<210>  5543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5543
agagcacggg agcuuuucuu                                                   20


<210>  5544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5544
uucaagaguc cacauuucca                                                   20


<210>  5545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5545
agaguccaca uuuccaggaa                                                   20


<210>  5546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5546
aggaaggcug gugagagcaa                                                   20


<210>  5547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5547
uggaaaugug gacucuugaa                                                   20


<210>  5548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5548
guaaccuggc aaggcagaau                                                   20


<210>  5549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5549
gccuugccag guuacugaaa                                                   20


<210>  5550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5550
cuuuauucug ccuugccagg                                                   20


<210>  5551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5551
agcuuguuca cuuuauucug                                                   20


<210>  5552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5552
uuccagcuug uucacuuuau                                                   20


<210>  5553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5553
ucgggacuac cugcaggcug                                                   20


<210>  5554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5554
auucacuuca cacugcagca                                                   20


<210>  5555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5555
cuucacacug cagcacuacu                                                   20


<210>  5556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5556
cacugcagca cuacucagcc                                                   20


<210>  5557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5557
agaggaagca ucuuguuuuc                                                   20


<210>  5558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5558
ucuggaaugu gaguccaaag                                                   20


<210>  5559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5559
cucagcugug gaaauucuuu                                                   20


<210>  5560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5560
acagcugagg gaaaacaaga                                                   20


<210>  5561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5561
uuuuggaaag cuuaagagca                                                   20


<210>  5562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5562
aaaaagaauu uccacagcug                                                   20


<210>  5563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5563
cauuggcagg acuacucucc                                                   20


<210>  5564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5564
ugauugcucu uuuucauuca                                                   20


<210>  5565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5565
uucaacaaag cuguggcaua                                                   20


<210>  5566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5566
acaaagcugu ggcauacgcu                                                   20


<210>  5567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5567
gcaggacacg uuagcguaug                                                   20


<210>  5568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5568
aacacaagac gacaaaguua                                                   20


<210>  5569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5569
guggcagcag caaccgccag                                                   20


<210>  5570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5570
cuggcgguug cugcugccac                                                   20


<210>  5571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5571
ucugaccuuc agugggaccg                                                   20


<210>  5572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5572
gugggaccgg aggccugaga                                                   20


<210>  5573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5573
ucacagucac cagaaccccc                                                   20


<210>  5574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5574
ggugacugug augaaggccu                                                   20


<210>  5575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5575
uucuagacaa auaaucugca                                                   20


<210>  5576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5576
agacaaauaa ucugcacaaa                                                   20


<210>  5577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5577
uuucauagaa auccaauugu                                                   20


<210>  5578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5578
uagaaaucca auuguuucuu                                                   20


<210>  5579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5579
augaaaagaa aacagauugg                                                   20


<210>  5580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5580
ucugcuuguu cucaucuuca                                                   20


<210>  5581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5581
gcuuguucuc aucuucaacu                                                   20


<210>  5582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5582
caucuucaac ucauaccucu                                                   20


<210>  5583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5583
acucauaccu cucuucucag                                                   20


<210>  5584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5584
cagagguugc aguuucugag                                                   20


<210>  5585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5585
gagaaacaca cugaaaaucc                                                   20


<210>  5586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5586
cagaaacugc aaccucugag                                                   20


<210>  5587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5587
guguguuucu cagaaacugc                                                   20


<210>  5588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5588
gcucagguga gaguugucuc                                                   20


<210>  5589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5589
cugaaagguu uuuccaguug                                                   20


<210>  5590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5590
gcgaaccauu ucagcucagg                                                   20


<210>  5591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5591
aguugauguu ucauuagaga                                                   20


<210>  5592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5592
uuagagacau uacucugugg                                                   20


<210>  5593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5593
gacaucugag augaaagguc                                                   20


<210>  5594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5594
ucucagaugu cagaacauua                                                   20


<210>  5595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5595
caguuucuac cauuagauau                                                   20


<210>  5596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5596
accauuagau auugagucuu                                                   20


<210>  5597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5597
aucacauaaa gcgauucaag                                                   20


<210>  5598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5598
agaccucagu caaguauugc                                                   20


<210>  5599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5599
uauaucauca ucccuaccuu                                                   20


<210>  5600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5600
ccuaugaagu uaagacauau                                                   20


<210>  5601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5601
uaggggaaaa gguagggaug                                                   20


<210>  5602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5602
uugcuacagu uuauaucuug                                                   20


<210>  5603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5603
aacauuucuu ugcuacaguu                                                   20


<210>  5604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5604
gauuucaaac auuucuuugc                                                   20


<210>  5605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5605
guucuagaga uuuuuccuga                                                   20


<210>  5606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5606
agagauuuuu ccugacaaga                                                   20


<210>  5607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5607
ugacaagaug ugcuauuauu                                                   20


<210>  5608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5608
uauguuacag cuagaaaaau                                                   20


<210>  5609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5609
agcuguaaca uaggaaucaa                                                   20


<210>  5610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5610
auguucaguu accuucuucu                                                   20


<210>  5611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5611
guuaccuucu ucuguagcca                                                   20


<210>  5612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5612
ucuguagcca cugcacagcc                                                   20


<210>  5613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5613
guagccacug cacagcccag                                                   20


<210>  5614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5614
caccacugga gcugggcugu                                                   20


<210>  5615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5615
ccuugaagua cuccuuagcu                                                   20


<210>  5616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5616
aggagaauuc ccaccacugg                                                   20


<210>  5617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5617
uucuuugcuu guuccuagug                                                   20


<210>  5618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5618
uugcuuguuc cuagugcuuc                                                   20


<210>  5619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5619
uagugcuuca uuuugaaacg                                                   20


<210>  5620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5620
uuuugaaacg uaaaugcuag                                                   20


<210>  5621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5621
aaaugaagca cuaggaacaa                                                   20


<210>  5622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5622
uuaaaauuca guugucuuua                                                   20


<210>  5623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5623
guugucuuua uauuugugau                                                   20


<210>  5624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5624
acuuaaaugg gguuccuaga                                                   20


<210>  5625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5625
uagaguaguc aaauucaugg                                                   20


<210>  5626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5626
uggagacaga aauuacaauu                                                   20


<210>  5627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5627
gucuccauga auuugacuac                                                   20


<210>  5628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5628
cccaggggcu gggggaaggg                                                   20


<210>  5629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5629
cccagccccu gggggaagca                                                   20


<210>  5630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5630
ucccuucccc cagccccugg                                                   20


<210>  5631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5631
auagguccag aguuucaguu                                                   20


<210>  5632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5632
guuucagaag augaaaagag                                                   20


<210>  5633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5633
gaagaugaaa agaguucugg                                                   20


<210>  5634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5634
gaaacugaaa cucuggaccu                                                   20


<210>  5635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5635
ucuucugaaa cugaaacucu                                                   20


<210>  5636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5636
ggagauggau gguggugaug                                                   20


<210>  5637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5637
cacugaugug caaccaucac                                                   20


<210>  5638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5638
gugacuuuaa guacauucac                                                   20


<210>  5639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5639
aauaguaaau uuuauguuau                                                   20


<210>  5640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5640
ccacaauuaa aaaaaaaaga                                                   20


<210>  5641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5641
uuuuuuuuua auugugguga                                                   20


<210>  5642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5642
uuuugcaguc aaucagccug                                                   20


<210>  5643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5643
aguuuucacu cuaugacucu                                                   20


<210>  5644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5644
cucuaugacu cuaggcaugu                                                   20


<210>  5645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5645
ugagguuagu acaguuguga                                                   20


<210>  5646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5646
ucuuuguaac aacuucauga                                                   20


<210>  5647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5647
ugacacggug ccuggguuca                                                   20


<210>  5648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5648
caagugcuca ggagcuacag                                                   20


<210>  5649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5649
aaucauguca ccuguagcuc                                                   20


<210>  5650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5650
gagguuaggg accuagagcc                                                   20


<210>  5651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5651
ggcucuaggu cccuaaccuc                                                   20


<210>  5652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5652
cauuaaugua acccagcuac                                                   20


<210>  5653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5653
cucaagguuu cucauuaaug                                                   20


<210>  5654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5654
ugagcuuuca cucaagguuu                                                   20


<210>  5655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5655
ugccuuucug acauaaggcc                                                   20


<210>  5656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5656
gacauaaggc cugaugggug                                                   20


<210>  5657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5657
gggauucuau aaagaucugu                                                   20


<210>  5658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5658
auaaagaucu gucacucuuu                                                   20


<210>  5659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5659
ccucauauuu uuuugagauc                                                   20


<210>  5660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5660
guaccuucca agcaagcagg                                                   20


<210>  5661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5661
aagcaagcag gcccugacug                                                   20


<210>  5662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5662
ccagguauca aaaccgggca                                                   20


<210>  5663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5663
ccuucugcuc auaugugacu                                                   20


<210>  5664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5664
gcucauaugu gacuuguaau                                                   20


<210>  5665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5665
ucccugcauu uuaauucaau                                                   20


<210>  5666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5666
auacuuacuu uugagcaaga                                                   20


<210>  5667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5667
ugucacucuu gcucaaaagu                                                   20


<210>  5668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5668
cucagcuuug augcaccaca                                                   20


<210>  5669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5669
cuucccucag cuuugaugca                                                   20


<210>  5670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5670
guugagucuu uuauuguuaa                                                   20


<210>  5671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5671
aaaaaucgac aaacuauuuu                                                   20


<210>  5672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5672
uuaucuguuu auuaaaauag                                                   20


<210>  5673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5673
guugagucag gcaccaccau                                                   20


<210>  5674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5674
aaugggugga aacacuacuu                                                   20


<210>  5675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5675
acccauuaga auuuagggau                                                   20


<210>  5676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5676
ccuaaaaguc aaacuugcag                                                   20


<210>  5677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5677
guucuccuaa aagucaaacu                                                   20


<210>  5678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5678
uguucaguuc uccuaaaagu                                                   20


<210>  5679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5679
ccuagagacu uuuccacaua                                                   20


<210>  5680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5680
acauaucaua uuacugagag                                                   20


<210>  5681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5681
aguacuuuua gauugauaaa                                                   20


<210>  5682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5682
uuuaucaauc uaaaaguacu                                                   20


<210>  5683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5683
gcaauuauca ccugcucuau                                                   20


<210>  5684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5684
ucauguugcu caggcugguc                                                   20


<210>  5685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5685
agucuagagu gcaguggcau                                                   20


<210>  5686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5686
agacggccug uguguggcuc                                                   20


<210>  5687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5687
aaaggguggc cugaaaagcu                                                   20


<210>  5688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5688
ggccacccuu uggaacgcug                                                   20


<210>  5689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5689
gcuuuucagg ccacccuuug                                                   20


<210>  5690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5690
acaacagaaa aaggcccuaa                                                   20


<210>  5691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5691
guuguagaaa aaagauuuaa                                                   20


<210>  5692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5692
gauuaagugg aaauacaggu                                                   20


<210>  5693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5693
acuuaaucug aaucauuuua                                                   20


<210>  5694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5694
accauuuacc uguauuucca                                                   20


<210>  5695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5695
uaacuaaacu uuuucuaaua                                                   20


<210>  5696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5696
aauaaauagc ucaggaaagc                                                   20


<210>  5697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5697
ugagcuauuu auuagaaaaa                                                   20


<210>  5698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5698
gaaaaagaaa gcccugccca                                                   20


<210>  5699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5699
gaaggcuaaa uuggcuuucc                                                   20


<210>  5700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5700
uuuucagaag gcuaaauugg                                                   20


<210>  5701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5701
cagucuacuc uuaaguuguu                                                   20


<210>  5702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5702
cauuucauga gccugacaac                                                   20


<210>  5703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5703
ugagccugac aacauccugc                                                   20


<210>  5704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5704
cuccccagug gcuacagagu                                                   20


<210>  5705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5705
acucuguagc cacuggggag                                                   20


<210>  5706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5706
uucuacucug uagccacugg                                                   20


<210>  5707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5707
ugcaucaggg aguggccguu                                                   20


<210>  5708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5708
acaagcuaac ggccacuccc                                                   20


<210>  5709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5709
ggggugcugu gaguuuuuuu                                                   20


<210>  5710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5710
uuuaccagau aaggcaagau                                                   20


<210>  5711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5711
ugacuaaaag aggagaaaug                                                   20


<210>  5712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5712
ccucuuuuag ucaggaaggu                                                   20


<210>  5713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5713
cacccuacac auuucuccuc                                                   20


<210>  5714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5714
gaccagaaug agggagccca                                                   20


<210>  5715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5715
ggucagaaaa auuaaaaccc                                                   20


<210>  5716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5716
acuguaucag ucacuguaga                                                   20


<210>  5717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5717
gccuccugcu acucucggug                                                   20


<210>  5718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5718
ggccaguucu gccuccugcu                                                   20


<210>  5719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5719
gucucaaaca caaauuugac                                                   20


<210>  5720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5720
auaaccuggg aaaggaagaa                                                   20


<210>  5721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5721
cagguuauug aagauccuau                                                   20


<210>  5722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5722
uuucccaggu uauugaagau                                                   20


<210>  5723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5723
uccuuuccca gguuauugaa                                                   20


<210>  5724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5724
uuuauuuacu aauuuuuguu                                                   20


<210>  5725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5725
uucuuuuauu uacuaauuuu                                                   20


<210>  5726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5726
uuauaauucu acccaagaga                                                   20


<210>  5727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5727
acccaagaga uuaauuuagu                                                   20


<210>  5728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5728
gaacuagccu gggcaacaaa                                                   20


<210>  5729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5729
gaacuccugg ccucaaguga                                                   20


<210>  5730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5730
uuuuuuauuu uuuagagaug                                                   20


<210>  5731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5731
agacagaguc ucccucuguu                                                   20


<210>  5732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5732
uuuuuucaag acagagucuc                                                   20


<210>  5733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5733
cuuaguuuua agauauauuu                                                   20


<210>  5734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5734
uuuccuaucu auguguugcu                                                   20


<210>  5735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5735
uaucuaugug uugcuaucaa                                                   20


<210>  5736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5736
cuguggguua ugaggacaua                                                   20


<210>  5737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5737
auacauuuuu acuaagcaag                                                   20


<210>  5738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5738
aguucuuagu acugaacugu                                                   20


<210>  5739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5739
uaguacugaa cugugcaugg                                                   20


<210>  5740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5740
guacuaagaa cuagaaauac                                                   20


<210>  5741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5741
ucuaucaaca acaaacccau                                                   20


<210>  5742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5742
uuuugguccu agugcuuuua                                                   20


<210>  5743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5743
uuacuuccuu uugguccuag                                                   20


<210>  5744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5744
aguucuuuac uuccuuuugg                                                   20


<210>  5745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5745
uacucaaaac ucuuuauuaa                                                   20


<210>  5746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5746
gugccaaggc cucuauggag                                                   20


<210>  5747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5747
ugauacucca uagaggccuu                                                   20


<210>  5748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5748
aagggaaccc aggcccucac                                                   20


<210>  5749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5749
aauucuugau acuccauaga                                                   20


<210>  5750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5750
cuucgaauuc uugauacucc                                                   20


<210>  5751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5751
uuagagagug agggccuggg                                                   20


<210>  5752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5752
gagguuccuu agagagugag                                                   20


<210>  5753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5753
aaugauucuc uuuccacaau                                                   20


<210>  5754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5754
cuuuccacaa uaccucuuga                                                   20


<210>  5755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5755
acaauaccuc uugaucuguc                                                   20


<210>  5756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5756
cacucagaau auucccagac                                                   20


<210>  5757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5757
gagugugaaa uaauaaggcc                                                   20


<210>  5758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5758
cagacuccua aauggucuuc                                                   20


<210>  5759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5759
aguucccaau cuugcauccu                                                   20


<210>  5760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5760
caaucuugca uccuucuuua                                                   20


<210>  5761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5761
uuacuccauc cuucaauaca                                                   20


<210>  5762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5762
auacaacugc cagaggauuu                                                   20


<210>  5763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5763
ccugcucuuc acacuucuga                                                   20


<210>  5764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5764
cacuucugag aguggaaaga                                                   20


<210>  5765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5765
gagaguggaa agaauccuac                                                   20


<210>  5766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5766
acucucagaa gugugaagag                                                   20


<210>  5767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5767
uuccacucuc agaaguguga                                                   20


<210>  5768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5768
guuucauggc ucuuaaaaau                                                   20


<210>  5769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5769
uggcucuuaa aaauauuuuu                                                   20


<210>  5770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5770
uaguacguac auacagucaa                                                   20


<210>  5771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5771
ggcuuuauag uuuaucaaau                                                   20


<210>  5772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5772
cagucacccu cagagguaca                                                   20


<210>  5773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5773
ccacuguagg cccuggcagg                                                   20


<210>  5774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5774
guccccugca cuacaguugu                                                   20


<210>  5775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5775
ugucagucau gugucuaaug                                                   20


<210>  5776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5776
uuuggucugc auuuauugag                                                   20


<210>  5777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5777
ccauucauuu ggucugcauu                                                   20


<210>  5778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5778
uaaauaaaag ugagucagaa                                                   20


<210>  5779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5779
gacucacuuu uauuuaggaa                                                   20


<210>  5780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5780
ugaaguaguu ggaacguauu                                                   20


<210>  5781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5781
ugaaauauug guaagucaua                                                   20


<210>  5782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5782
aacuacuuca ugaaauauug                                                   20


<210>  5783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5783
uuaacucaug agguggagcc                                                   20


<210>  5784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5784
aguugguucu gaaauauuuu                                                   20


<210>  5785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5785
gaaauauuuu uuaaaagcau                                                   20


<210>  5786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5786
gaaccaacua gaaacggcuc                                                   20


<210>  5787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5787
guggaaagca uauuggaaug                                                   20


<210>  5788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5788
acugaaguuu uuaugcuuuu                                                   20


<210>  5789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5789
aauaugcuuu ccacugaagu                                                   20


<210>  5790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5790
agcucuauca ccuucuggcc                                                   20


<210>  5791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5791
ggccgacccu ggacaaguca                                                   20


<210>  5792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5792
aggccuuagu uucucaaaug                                                   20


<210>  5793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5793
caaaugcuaa gucugggaac                                                   20


<210>  5794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5794
cagacuuagc auuugagaaa                                                   20


<210>  5795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5795
guucccagac uuagcauuug                                                   20


<210>  5796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5796
uccagcugca acacucugau                                                   20


<210>  5797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5797
agcugcaaca cucugauacu                                                   20


<210>  5798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5798
uaguaaagua ucagaguguu                                                   20


<210>  5799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5799
uaauuucaua guaaaguauc                                                   20


<210>  5800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5800
ccuuccuaau uucauaguaa                                                   20


<210>  5801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5801
uuucuccuuc cuaauuucau                                                   20


<210>  5802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5802
uuucuuuucu ccuuccuaau                                                   20


<210>  5803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5803
agucacuaaa cagauccgau                                                   20


<210>  5804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5804
agaagaugcu gguagagcua                                                   20


<210>  5805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5805
ggaaaacaaa cuaggauaug                                                   20


<210>  5806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5806
uguagcucua ccagcaucuu                                                   20


<210>  5807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5807
cauuuguauu cuuguagcuc                                                   20


<210>  5808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5808
uagcauccuu aacucagagu                                                   20


<210>  5809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5809
auuuuauaag cugacuuuuu                                                   20


<210>  5810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5810
cuuaguauau cuuggcacau                                                   20


<210>  5811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5811
ucacuuagua uaucuuggca                                                   20


<210>  5812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5812
uagaacacac uccuucagcc                                                   20


<210>  5813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5813
augaauuuug ccuucuucac                                                   20


<210>  5814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5814
gccauuuuaa uaaaauuuau                                                   20


<210>  5815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5815
cacuuuuaua cauauaaauu                                                   20


<210>  5816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5816
aagaggccag guacaguacu                                                   20


<210>  5817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5817
cguauuauac caccucacug                                                   20


<210>  5818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5818
gugagguggu auaauacgug                                                   20


<210>  5819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5819
cagguuguga ggauucagug                                                   20


<210>  5820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5820
ucuaugacug acuucacagg                                                   20


<210>  5821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5821
uccucuauga cugacuucac                                                   20


<210>  5822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5822
ucucuuugcu auuuacuaau                                                   20


<210>  5823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5823
cuacagaccu auaucagagg                                                   20


<210>  5824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5824
uguuaacacu acauguauca                                                   20


<210>  5825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5825
uuuaugcacc aguauuuaua                                                   20


<210>  5826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5826
gcaugccuuc uuuuaugcac                                                   20


<210>  5827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5827
gugggcagaa acuaauauau                                                   20


<210>  5828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5828
gcccacagaa uuucugcaug                                                   20


<210>  5829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5829
acuauguaua uauuaguuuc                                                   20


<210>  5830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5830
uauaaagagg ccuggaagga                                                   20


<210>  5831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5831
aggccucuuu auaugaauuu                                                   20


<210>  5832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5832
uuccaggccu cuuuauauga                                                   20


<210>  5833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5833
uauuuauuua uuuauuauuu                                                   20


<210>  5834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5834
uggccuauau uuuuucuuuu                                                   20


<210>  5835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5835
uuuggccuca uuucuaugcu                                                   20


<210>  5836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5836
augcuuaaau uuuucccaaa                                                   20


<210>  5837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5837
caaagagagu guaguaauua                                                   20


<210>  5838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5838
uuuuuaaucu uuaauuuuua                                                   20


<210>  5839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5839
aguauaggcu caguuuuauu                                                   20


<210>  5840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5840
uaaucauucu aguauaggcu                                                   20


<210>  5841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5841
cauagccuaa guuguuuuuc                                                   20


<210>  5842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5842
uuaagguaag accucaguua                                                   20


<210>  5843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5843
caaugcugca uuucauuaag                                                   20


<210>  5844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5844
uucacaaugc ugcauuucau                                                   20


<210>  5845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5845
guaaugagca uuuuuccuuc                                                   20


<210>  5846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5846
caccagguaa uguuugcuuu                                                   20


<210>  5847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5847
caugucacag uuaacacucc                                                   20


<210>  5848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5848
guuaaaggca gcaacaacag                                                   20


<210>  5849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5849
ggcaguguua auuaucuuaa                                                   20


<210>  5850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5850
uaacuguuag aagucuauag                                                   20


<210>  5851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5851
aacaguuaag aaacccuguu                                                   20


<210>  5852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5852
gggugucuaa gccugucuga                                                   20


<210>  5853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5853
gacaggcuua gacacccuga                                                   20


<210>  5854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5854
ggagucguuu ccaucaguuu                                                   20


<210>  5855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5855
aucaguuuuu caaaggcaaa                                                   20


<210>  5856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5856
aaggcaaaag cucccacaau                                                   20


<210>  5857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5857
gguuuuuuuu uuuaaauuaa                                                   20


<210>  5858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5858
uagauucaca uaucuguaaa                                                   20


<210>  5859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5859
cauaucugua aaucagguag                                                   20


<210>  5860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5860
cuaccugauu uacagauaug                                                   20


<210>  5861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5861
ucccuaccug auuuacagau                                                   20


<210>  5862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5862
aguccuucuu cccuaccuga                                                   20


<210>  5863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5863
agcagagccg cccccagcug                                                   20


<210>  5864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5864
ccuuccagca gagccgcccc                                                   20


<210>  5865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5865
gaguuguagu auuccaggac                                                   20


<210>  5866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5866
aggaccagga acacacaaaa                                                   20


<210>  5867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5867
ugguccugga auacuacaac                                                   20


<210>  5868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5868
uccccaaucu cuuuugugug                                                   20


<210>  5869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5869
uuaauuguag aggguuucau                                                   20


<210>  5870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5870
uccaucaaaa ucauuucguu                                                   20


<210>  5871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5871
gccaaggucc agaccuccag                                                   20


<210>  5872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5872
guucagccaa gguccagacc                                                   20


<210>  5873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5873
cuuccacuaa uuauuucuuu                                                   20


<210>  5874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5874
acuaauuauu ucuuuuugac                                                   20


<210>  5875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5875
uuuugacaua uaagaaaacu                                                   20


<210>  5876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5876
uauaugucaa aaagaaauaa                                                   20


<210>  5877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5877
aauuaaguuu ucuuauaugu                                                   20


<210>  5878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5878
uucaaauuaa guuuucuuau                                                   20


<210>  5879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5879
uaacaauacu cuucaugcca                                                   20


<210>  5880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5880
ugccaaacau aacucguaac                                                   20


<210>  5881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5881
ucaaacagga gggaaaaaaa                                                   20


<210>  5882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5882
cuccuguuug aggaaaauug                                                   20


<210>  5883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5883
aaagccauuu uuuucccucc                                                   20


<210>  5884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5884
cuucagacau gaacaacaag                                                   20


<210>  5885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5885
gacaugaaca acaaggcuuc                                                   20


<210>  5886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5886
ugucugaagg gaaaccuuac                                                   20


<210>  5887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5887
accuccucau ggaggggcaa                                                   20


<210>  5888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5888
uuggucuccu aaagcuccug                                                   20


<210>  5889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5889
guuuuguuuc uuuggucucc                                                   20


<210>  5890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5890
uauggaugug uauuuugugg                                                   20


<210>  5891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5891
agacucgcac acacacugag                                                   20


<210>  5892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5892
cugugugugc gaguacugug                                                   20


<210>  5893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5893
cacuccauaa ucuuucaaag                                                   20


<210>  5894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5894
aagagguaaa aauauaaaua                                                   20


<210>  5895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5895
uaaacuauuu auauuuuuac                                                   20


<210>  5896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5896
gcaguauuuc auaaacuauu                                                   20


<210>  5897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5897
guggcagcuu ucggcaguau                                                   20


<210>  5898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5898
ccacuguauc uucaguggca                                                   20


<210>  5899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5899
guuccucaaa caacuguucu                                                   20


<210>  5900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5900
ucaaacaacu guucucaaau                                                   20


<210>  5901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5901
caaauaaugg cuaacaccac                                                   20


<210>  5902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5902
gcuuagcaua ggugguguua                                                   20


<210>  5903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5903
auauggguug auucugcuua                                                   20


<210>  5904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5904
uuugcuagaa aaaccagaau                                                   20


<210>  5905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5905
agcaaaugaa auaacuccuu                                                   20


<210>  5906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5906
gguuuuucua gcaaaugaaa                                                   20


<210>  5907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5907
uuacaaaauu gucugaacuc                                                   20


<210>  5908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5908
gacaauuuug uaacgaaaau                                                   20


<210>  5909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5909
uccaaugucc cuuuagagag                                                   20


<210>  5910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5910
cuaucagaag gaugcucugu                                                   20


<210>  5911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5911
gauagagaaa ugcuuauuga                                                   20


<210>  5912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5912
ugccauuaga ucuuccuagu                                                   20


<210>  5913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5913
uaguagcuuc ugggucugag                                                   20


<210>  5914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5914
gggucugagu uugcauucau                                                   20


<210>  5915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5915
ugccuuggcu ucuaugccac                                                   20


<210>  5916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5916
augccacuaa cuagcuguau                                                   20


<210>  5917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5917
gugccuuagu uuuugcaucc                                                   20


<210>  5918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5918
uccugucuau ggaugcaaaa                                                   20


<210>  5919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5919
gugugcugug cuuuaaauuu                                                   20


<210>  5920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5920
guguuuucug ugugcugugc                                                   20


<210>  5921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5921
ugggucuugu caugauagug                                                   20


<210>  5922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5922
gggagacaaa auggaaaaug                                                   20


<210>  5923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5923
auuuugucuc ccagaacuaa                                                   20


<210>  5924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5924
aauauauuuc aaugauguaa                                                   20


<210>  5925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5925
augauguaau uuauaucugc                                                   20


<210>  5926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5926
ccagguauaa ugagauaaug                                                   20


<210>  5927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5927
uuuugcacug aagaucagaa                                                   20


<210>  5928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5928
gugcaaaaug aaaauacuca                                                   20


<210>  5929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5929
gaucuucagu gcaaaaugaa                                                   20


<210>  5930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5930
cgaaacuagg agacuccagc                                                   20


<210>  5931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5931
ugaaccugac cguucugauc                                                   20


<210>  5932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5932
acacaguagu gguucaaauu                                                   20


<210>  5933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5933
aauuaaggug auaaaugagc                                                   20


<210>  5934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5934
gagcucauuu aucaccuuaa                                                   20


<210>  5935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5935
uuugggagag gugagagggu                                                   20


<210>  5936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5936
cuuauggcaa acuaguaaaa                                                   20


<210>  5937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5937
uguuaaacuu uauaauauuu                                                   20


<210>  5938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5938
acuacuugcu aguugaggug                                                   20


<210>  5939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5939
cauucgacua cuugcuaguu                                                   20


<210>  5940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5940
uuuacuugcu aauauaauua                                                   20


<210>  5941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5941
guaucucuuc auucuaagau                                                   20


<210>  5942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5942
uucuaagaua uguuaagcuu                                                   20


<210>  5943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5943
aagauauguu aagcuuacca                                                   20


<210>  5944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5944
uuugggauga gacaucugaa                                                   20


<210>  5945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5945
gaugucucau cccaaaggaa                                                   20


<210>  5946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5946
caauacagug gcguuacuug                                                   20


<210>  5947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5947
caaauucucg ugcuugugcu                                                   20


<210>  5948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5948
cgugcuugug cugaacucca                                                   20


<210>  5949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5949
gcacaagcac gagaauuugg                                                   20


<210>  5950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5950
cugaugacag auacgucgau                                                   20


<210>  5951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5951
gacgacaaca cuaacagcca                                                   20


<210>  5952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5952
uauuauuucu gacgacaaca                                                   20


<210>  5953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5953
ucuucauauu auuucugacg                                                   20


<210>  5954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5954
uaauauucug ggcuuuaauu                                                   20


<210>  5955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5955
gggcuuuaau uauuucucag                                                   20


<210>  5956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5956
cagugcuuga cagaagaggu                                                   20


<210>  5957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5957
gucaagcacu gagaaauaau                                                   20


<210>  5958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5958
aaaaccaguc ccuuuaugga                                                   20


<210>  5959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5959
cuguagguac ugagugcuua                                                   20


<210>  5960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5960
cauuauacug aggcacguug                                                   20


<210>  5961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5961
ucaccacaac aguaucuuga                                                   20


<210>  5962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5962
ccacaacagu aucuugaguu                                                   20


<210>  5963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5963
ucauguacug gcagagguaa                                                   20


<210>  5964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5964
uguacuggca gagguaaggc                                                   20


<210>  5965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5965
gccuacuuug ugauuuugag                                                   20


<210>  5966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5966
uuuaguccuc aaaaucacaa                                                   20


<210>  5967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5967
cuuuuaauau uucauuuagu                                                   20


<210>  5968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5968
aaaguagaaa ugugcuccac                                                   20


<210>  5969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5969
acuuuugaaa acauuuucac                                                   20


<210>  5970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5970
gcugcaugua uaauuaauac                                                   20


<210>  5971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5971
cuauaauuca gcugcaugua                                                   20


<210>  5972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5972
auauccaagg ccccauuguc                                                   20


<210>  5973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5973
aacucuucca uauccaaggc                                                   20


<210>  5974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5974
acuucaaacu cuuccauauc                                                   20


<210>  5975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5975
acauaguauc cacacacaga                                                   20


<210>  5976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5976
cuuuaguguu aaaaaaacaa                                                   20


<210>  5977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5977
ucucagcuuu cucuuuagug                                                   20


<210>  5978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5978
acuuaggcuu ccucucagcu                                                   20


<210>  5979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5979
ugcuaaggga gacagauuuu                                                   20


<210>  5980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5980
uuuccugcua agggagacag                                                   20


<210>  5981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5981
ccugugugua aacacauuac                                                   20


<210>  5982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5982
gacccagcuc ugcugguguc                                                   20


<210>  5983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5983
caggcaagga guaaagcuca                                                   20


<210>  5984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5984
uccccauucu caggcaagga                                                   20


<210>  5985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5985
ucaaaauuaa gcagcuucau                                                   20


<210>  5986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5986
uguauuuuga aucuaucaaa                                                   20


<210>  5987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5987
aaauacauga aaugcuaaca                                                   20


<210>  5988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5988
uuuauuugau agauucaaaa                                                   20


<210>  5989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5989
cccauccauc guauuucuuu                                                   20


<210>  5990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5990
aacaggagag uugguuuugg                                                   20


<210>  5991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5991
acacuauucu aacaaaacaa                                                   20


<210>  5992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5992
aacaaaacaa ccucgguaag                                                   20


<210>  5993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5993
ccauguugcc caaacugguc                                                   20


<210>  5994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5994
auacaaaaua caaaguuagc                                                   20


<210>  5995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5995
gugauccucc cuccucagcc                                                   20


<210>  5996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5996
ggguuucagu gauccucccu                                                   20


<210>  5997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5997
uuuucauuug aacaagagua                                                   20


<210>  5998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5998
uuugaacaag aguauuauau                                                   20


<210>  5999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  5999
aaugaaaagg aaguuguuug                                                   20


<210>  6000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6000
guuuauaaca gcacaacuuu                                                   20


<210>  6001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6001
ggcuguguuu ucagcaucug                                                   20


<210>  6002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6002
gcaucugacu uaaaagaacc                                                   20


<210>  6003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6003
uuuaagucag augcugaaaa                                                   20


<210>  6004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6004
cagccccaga gaggaaguag                                                   20


<210>  6005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6005
ucucuggggc ugugaacaag                                                   20


<210>  6006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6006
acuuccucuc uggggcugug                                                   20


<210>  6007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6007
cuaaagguuu uugaaacccc                                                   20


<210>  6008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6008
aaaaccuuua gggaauaggu                                                   20


<210>  6009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6009
gacuggggag gggguuucaa                                                   20


<210>  6010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6010
cucuuaugac uuugucacua                                                   20


<210>  6011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6011
auggguuauu agacuaaauu                                                   20


<210>  6012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6012
uacaauuuag ucuaauaacc                                                   20


<210>  6013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6013
ucauacaauu uagucuaaua                                                   20


<210>  6014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6014
uuggaguuaa auuaucuuua                                                   20


<210>  6015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6015
agucucuaug guacuacuac                                                   20


<210>  6016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6016
uaaaagucua aguaguagua                                                   20


<210>  6017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6017
uuuuguaggu gauaaauguu                                                   20


<210>  6018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6018
uagccgcugu guuucuuuuu                                                   20


<210>  6019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6019
acuagggaua uaaaaguagu                                                   20


<210>  6020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6020
uccuaggggc cagucggcaa                                                   20


<210>  6021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6021
gcucugcggc acaugaucag                                                   20


<210>  6022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6022
gaggcauuca gcucugcggc                                                   20


<210>  6023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6023
ucugaggcau ucagcucugc                                                   20


<210>  6024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6024
uugcugucac aagauauuga                                                   20


<210>  6025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6025
caauaucuug ugacagcaag                                                   20


<210>  6026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6026
auccagacaa aaauugguuu                                                   20


<210>  6027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6027
auuuagcugu guuuuuaaaa                                                   20


<210>  6028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6028
uaaaaaauau auugacuccu                                                   20


<210>  6029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6029
auauagaaag uacuuguuaa                                                   20


<210>  6030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6030
auauggaaau aauauucuua                                                   20


<210>  6031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6031
caauaacuac uaaacaauua                                                   20


<210>  6032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6032
acugcuauca augaguaacu                                                   20


<210>  6033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6033
gaugaggugg guauaguuac                                                   20


<210>  6034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6034
uacaaguaau auaauucaca                                                   20


<210>  6035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6035
caagauuuuu aggaagaaac                                                   20


<210>  6036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6036
uaaaaaucuu gugaauuaua                                                   20


<210>  6037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6037
uccuaaaaau cuugugaauu                                                   20


<210>  6038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6038
auaugguaug uuuuuuauga                                                   20


<210>  6039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6039
guauuaggaa aagauauuag                                                   20


<210>  6040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6040
uaauacagaa gauuuauacu                                                   20


<210>  6041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6041
uaauaucuuu uccuaauaca                                                   20


<210>  6042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6042
acacuuuugu acaaaaggua                                                   20


<210>  6043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6043
uguucaacac uuuuguacaa                                                   20


<210>  6044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6044
gggacgucuu uguccaacag                                                   20


<210>  6045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6045
ucaguuacug gagguacuac                                                   20


<210>  6046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6046
ucuaaccagu uaaaaagccu                                                   20


<210>  6047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6047
uguaauuuua ucuuuccucu                                                   20


<210>  6048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6048
ucauguaauu uuaucuuucc                                                   20


<210>  6049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6049
uuuucuucau guaauuuuau                                                   20


<210>  6050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6050
uauggugguu uaccucaaau                                                   20


<210>  6051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6051
uuuuguucuu auggugguuu                                                   20


<210>  6052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6052
gauggacuua ugcuuugaag                                                   20


<210>  6053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6053
aagcauaagu ccaucugaau                                                   20


<210>  6054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6054
guuuuugcuc uucaaagcau                                                   20


<210>  6055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6055
agagaaagau ugguaccaua                                                   20


<210>  6056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6056
cuggaaggua aaauggauaa                                                   20


<210>  6057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6057
uuuaauuauu gcuaugguac                                                   20


<210>  6058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6058
guuccuagau uucagaguca                                                   20


<210>  6059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6059
uagauuucag agucaagggc                                                   20


<210>  6060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6060
gagucaaggg caucaauucu                                                   20


<210>  6061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6061
accgcugagu cacauuuucu                                                   20


<210>  6062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6062
ccagagccag uaucucucug                                                   20


<210>  6063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6063
cuaaacaccc caccuuuuuu                                                   20


<210>  6064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6064
gaaucccucc cuccacuacg                                                   20


<210>  6065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6065
gaaaugucuu cccuaaacac                                                   20


<210>  6066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6066
ucacauaauc acagaugcaa                                                   20


<210>  6067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6067
cauaaucaca gaugcaaaga                                                   20


<210>  6068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6068
uugcaucugu gauuauguga                                                   20


<210>  6069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6069
agccccuaug ccugugucug                                                   20


<210>  6070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6070
gucaggcugu ugcuauccau                                                   20


<210>  6071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6071
cggcugaguc gauaucaccg                                                   20


<210>  6072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6072
augaggcguc agcgggcucu                                                   20


<210>  6073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6073
aagcuuucca ugaggcguca                                                   20


<210>  6074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6074
aaacaaauaa aauguuuuuc                                                   20


<210>  6075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6075
ucuuucccuc ccaccccaac                                                   20


<210>  6076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6076
uucccuccca ccccaacugu                                                   20


<210>  6077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6077
cucccacccc aacuguuuuu                                                   20


<210>  6078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6078
agggacuugu ccaaaaacag                                                   20


<210>  6079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6079
ucugugaucu agauuuaaga                                                   20


<210>  6080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6080
uuuccucuga agaugguauu                                                   20


<210>  6081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6081
ucugaagaug guauucauac                                                   20


<210>  6082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6082
gaggaaacga acuaaugaga                                                   20


<210>  6083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6083
uacuucugca auauucccau                                                   20


<210>  6084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6084
gcaauauucc cauccauccu                                                   20


<210>  6085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6085
cauccauccu gucacaccca                                                   20


<210>  6086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6086
uuuucaaagu acuuuacaag                                                   20


<210>  6087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6087
aaguacuuua caagauaaag                                                   20


<210>  6088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6088
auuuacgggg ggaggggggc                                                   20


<210>  6089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6089
ugucuauuug ccccccuccc                                                   20


<210>  6090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6090
gucugaugcc cagcugaugg                                                   20


<210>  6091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6091
cugagcaaau ggcuuccaag                                                   20


<210>  6092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6092
aaguguaugg ccgccauucc                                                   20


<210>  6093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6093
cuucucuuuc ugccgccugc                                                   20


<210>  6094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6094
cuuucugccg ccugcugucc                                                   20


<210>  6095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6095
gccgccugcu guccugccuu                                                   20


<210>  6096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6096
aaugcagaug uuggcuuugc                                                   20


<210>  6097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6097
uagaaucugu auuuaguuca                                                   20


<210>  6098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6098
aggaauuacu gcuucaaaug                                                   20


<210>  6099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6099
uugaggcaca augccuccag                                                   20


<210>  6100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6100
uauaaacauu agcuggaggc                                                   20


<210>  6101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6101
caacaaauug gcuucuuaua                                                   20


<210>  6102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6102
aaguuuucca uguaguguca                                                   20


<210>  6103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6103
auguaguguc agcuguuuga                                                   20


<210>  6104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6104
aacagcugac acuacaugga                                                   20


<210>  6105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6105
caagauugcu guuucaaaca                                                   20


<210>  6106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6106
uccaggggcg uuaaguccuu                                                   20


<210>  6107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6107
agagagaaaa ucccaacgca                                                   20


<210>  6108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6108
cucuagaaac acucccuuuu                                                   20


<210>  6109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6109
ggccugcuuu ggucugcguu                                                   20


<210>  6110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6110
uggccuaccc ugguguuugg                                                   20


<210>  6111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6111
uauuaccugc aauuuaaaac                                                   20


<210>  6112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6112
ccagaauggu ggccacagca                                                   20


<210>  6113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6113
ggagaaaacc cuagacagug                                                   20


<210>  6114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6114
cucacauugc acuccaguaa                                                   20


<210>  6115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6115
uacuggagug caaugugaga                                                   20


<210>  6116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6116
ggauuuucuu acuggagugc                                                   20


<210>  6117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6117
uucaggauuu ucuuacugga                                                   20


<210>  6118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6118
cuuucuuuca ggauuuucuu                                                   20


<210>  6119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6119
caccaccuuu cucuuucuuu                                                   20


<210>  6120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6120
acaaccucaa ccuucccaug                                                   20


<210>  6121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6121
gauacacgcu gaaaauuuau                                                   20


<210>  6122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6122
gcguguaucu gaagguaaag                                                   20


<210>  6123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6123
caauaaauuu ucagcgugua                                                   20


<210>  6124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6124
gagagacaaa aaagccugca                                                   20


<210>  6125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6125
gacuacuaac augaaggaua                                                   20


<210>  6126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6126
uuagaucaau cuguaagcaa                                                   20


<210>  6127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6127
uaguaaauau ugcuuacaga                                                   20


<210>  6128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6128
uguuugaaga auuaaugauc                                                   20


<210>  6129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6129
uuauaaagac caaucacuca                                                   20


<210>  6130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6130
uucuuuauaa agaccaauca                                                   20


<210>  6131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6131
ugauggaguu uauuauaguu                                                   20


<210>  6132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6132
uccugaugga guuuauuaua                                                   20


<210>  6133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6133
acauucuucc ugauggaguu                                                   20


<210>  6134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6134
cugggauucu ugagcauuag                                                   20


<210>  6135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6135
ugagcauuag gaauaccaag                                                   20


<210>  6136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6136
uaaugcucaa gaaucccagu                                                   20


<210>  6137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6137
aacaaauuag aucacauuac                                                   20


<210>  6138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6138
uuuucaaaca aauuagauca                                                   20


<210>  6139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6139
gcaacagacc uguucuuuuu                                                   20


<210>  6140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6140
uucagcaaca gaccuguucu                                                   20


<210>  6141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6141
cucuaaucua uuucauucag                                                   20


<210>  6142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6142
uguggucacu gaauacuugc                                                   20


<210>  6143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6143
gugaccacaa gaagagccug                                                   20


<210>  6144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6144
ggucacucca aaaucaucuc                                                   20


<210>  6145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6145
ucacuguuuc agugaagaga                                                   20


<210>  6146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6146
gugaagagag uuuaaaauag                                                   20


<210>  6147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6147
cugaaacagu gaggaaauaa                                                   20


<210>  6148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6148
gcuuaaaguc uauuuuaaac                                                   20


<210>  6149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6149
aguugaaaua aaaaggguua                                                   20


<210>  6150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6150
acuugaaauu auuguucugc                                                   20


<210>  6151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6151
uauaacccuu uuuauuucaa                                                   20


<210>  6152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6152
gcucuaaauc acuggaagag                                                   20


<210>  6153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6153
agugauuuag agcugaaguu                                                   20


<210>  6154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6154
uuuaauuaaa agacuccaac                                                   20


<210>  6155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6155
cguccuucag aacuaauaaa                                                   20


<210>  6156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6156
gaacuaauaa aauauucaac                                                   20


<210>  6157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6157
gaaggacgag aauugauaaa                                                   20


<210>  6158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6158
acuaaccacu gacaagcauc                                                   20


<210>  6159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6159
aaaaguuuug augcuuguca                                                   20


<210>  6160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6160
augguagcaa uccauucuuc                                                   20


<210>  6161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6161
ucaguaucaa cccuuuaaaa                                                   20


<210>  6162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6162
guaucaaccc uuuaaaaaaa                                                   20


<210>  6163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6163
auuuuguuua uauggccauu                                                   20


<210>  6164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6164
caaacaaaag ugaccaaucc                                                   20


<210>  6165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6165
uuuaaugucu ggcauaggau                                                   20


<210>  6166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6166
uuuucagaua auaaagacug                                                   20


<210>  6167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6167
gauaauaaag acugagauca                                                   20


<210>  6168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6168
gcaccuggua aggugccugc                                                   20


<210>  6169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6169
ucauugguuu uaugguuuuu                                                   20


<210>  6170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6170
aaggcagagg uccccaagcc                                                   20


<210>  6171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6171
acaaaaggga ggguuggggg                                                   20


<210>  6172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6172
augaaaccac ucccuguugc                                                   20


<210>  6173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6173
uggaagacaa uuuuuccaca                                                   20


<210>  6174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6174
aaggcauuac ucuggacaua                                                   20


<210>  6175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6175
cuguucaaaa accuuucacg                                                   20


<210>  6176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6176
aaaaccuuuc acgaucuccc                                                   20


<210>  6177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6177
aagauguaca gaauuuauac                                                   20


<210>  6178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6178
aauugggcaa aaucauaucc                                                   20


<210>  6179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6179
guacaucuuc gaauugggca                                                   20


<210>  6180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6180
caccugaguu ucuucuuugu                                                   20


<210>  6181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6181
ucuuuguccg uagauaaguu                                                   20


<210>  6182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6182
uuguccguag auaaguuuga                                                   20


<210>  6183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6183
aacuuaucua cggacaaaga                                                   20


<210>  6184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6184
uuuuucaaac uuaucuacgg                                                   20


<210>  6185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6185
auuccuuuuu caaacuuauc                                                   20


<210>  6186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6186
cucucuuaga cuaaauuaaa                                                   20


<210>  6187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6187
uguuucccuc ucuuagacua                                                   20


<210>  6188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6188
cagaaguuuu auagauuauu                                                   20


<210>  6189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6189
gugaaaaaua uccucuuuca                                                   20


<210>  6190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6190
uaacugugua auaaucuaua                                                   20


<210>  6191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6191
uauauugugu guguaucaua                                                   20


<210>  6192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6192
auuuaaauuu uuaaaaaggu                                                   20


<210>  6193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6193
uaaccuuuuu aaaaauuuaa                                                   20


<210>  6194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6194
uuucuuuuau gaaauccucu                                                   20


<210>  6195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6195
uuuaugaaau ccucucaaaa                                                   20


<210>  6196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6196
uaaaagaaau gaagacaaug                                                   20


<210>  6197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6197
acuacuuuuc cuugaguacc                                                   20


<210>  6198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6198
uaauuuguaa uaaaauauca                                                   20


<210>  6199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6199
uauuucuaac aauccaguua                                                   20


<210>  6200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6200
aacaauccag uuaguuacuu                                                   20


<210>  6201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6201
augaagcuaa agacaaaaca                                                   20


<210>  6202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6202
uugaaugcug uaaguaacua                                                   20


<210>  6203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6203
guuuuguuuu gucuuuagcu                                                   20


<210>  6204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6204
ucauaaacuu gagguucuca                                                   20


<210>  6205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6205
uaaacuugag guucucaucu                                                   20


<210>  6206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6206
caucucucac caucuacaaa                                                   20


<210>  6207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6207
uuuguagaug gugagagaug                                                   20


<210>  6208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6208
uaaaaauaau uauuaaucuu                                                   20


<210>  6209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6209
auuucauaaa aauaauuauu                                                   20


<210>  6210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6210
auaugugaag gacauuucua                                                   20


<210>  6211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6211
cuuuuuauaa gugcuuuuua                                                   20


<210>  6212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6212
ccuuucucaa guuuugaacu                                                   20


<210>  6213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6213
caaguuuuga acuuuuaaaa                                                   20


<210>  6214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6214
aaacuugaga aaggggaauu                                                   20


<210>  6215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6215
cucuccucuu uuaaaaguuc                                                   20


<210>  6216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6216
uuugacauau aagauguuau                                                   20


<210>  6217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6217
uauaacaucu uauaugucaa                                                   20


<210>  6218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6218
uuaaaccaua cccuuuuggg                                                   20


<210>  6219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6219
caaaagggua ugguuuaaug                                                   20


<210>  6220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6220
gguaaacugc caugugaagg                                                   20


<210>  6221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6221
cauggcaguu uaccugaauu                                                   20


<210>  6222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6222
uuuguccuuc acauggcagu                                                   20


<210>  6223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6223
gaauuuagau ccuuguccug                                                   20


<210>  6224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6224
gaacugucua cucaguccag                                                   20


<210>  6225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6225
ucuuuucuga accuguuuuu                                                   20


<210>  6226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6226
uuucugaacc uguuuuucca                                                   20


<210>  6227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6227
gaaccuguuu uuccauccaa                                                   20


<210>  6228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6228
gaaaagaaga aguaugugcc                                                   20


<210>  6229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6229
auccaaaaaa ugagaauaaa                                                   20


<210>  6230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6230
cauuuuuugg auggaaaaac                                                   20


<210>  6231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6231
cccuuagaau uuuuuauaug                                                   20


<210>  6232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6232
aagggggaau auccacgugg                                                   20


<210>  6233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6233
uaccugguau auucgagcag                                                   20


<210>  6234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6234
agcaggcauu uucuccacaa                                                   20


<210>  6235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6235
ccacaaacag uccuuucuuc                                                   20


<210>  6236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6236
ucucgccuuu uuuaaccagc                                                   20


<210>  6237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6237
cgccuuuuuu aaccagcuug                                                   20


<210>  6238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6238
uaccaagcug guuaaaaaag                                                   20


<210>  6239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6239
gccuaugggg ccgaggggau                                                   20


<210>  6240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6240
ccucagucau ccccucggcc                                                   20


<210>  6241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6241
ggugaagaug gagcugaccu                                                   20


<210>  6242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6242
ccagaaauuu caccucaguc                                                   20


<210>  6243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6243
aucucuuagg ucagcuccau                                                   20


<210>  6244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6244
gauucuaucu cuuaggucag                                                   20


<210>  6245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6245
auacauguau aauaaucaaa                                                   20


<210>  6246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6246
uaauuguuac auuaugauug                                                   20


<210>  6247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6247
aauuaguugg gagaacugau                                                   20


<210>  6248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6248
cccaacuaau uagaaaguau                                                   20


<210>  6249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6249
auaaugucaa ucaguucucc                                                   20


<210>  6250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6250
uuuugugcuu aaauguuaaa                                                   20


<210>  6251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6251
uccuucauau uauugugaga                                                   20


<210>  6252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6252
uucauauuau ugugagauau                                                   20


<210>  6253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6253
uauuauugug agauaucuuu                                                   20


<210>  6254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6254
cagccauuaa aaaagcagug                                                   20


<210>  6255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6255
cugcuuuuuu aauggcuggg                                                   20


<210>  6256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6256
cacaugaaaa aguaaacacu                                                   20


<210>  6257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6257
ugugagaaau augacuauau                                                   20


<210>  6258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6258
ugacccaaua uauuaaaagg                                                   20


<210>  6259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6259
auucuagaau gaaauaacuu                                                   20


<210>  6260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6260
agaaugaaau aacuuacgug                                                   20


<210>  6261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6261
agaauugaag uguuuuguuu                                                   20


<210>  6262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6262
uucuagaauu gaaguguuuu                                                   20


<210>  6263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6263
aaauauguaa caacuucuug                                                   20


<210>  6264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6264
ugccaagaaa auaaccauga                                                   20


<210>  6265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6265
uggcaagaag uuguuacaua                                                   20


<210>  6266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6266
auggugauga uguggucugu                                                   20


<210>  6267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6267
auguaauuug cugugugauu                                                   20


<210>  6268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6268
ugccguacaa cgcugacucg                                                   20


<210>  6269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6269
uugguaauac uggggaguuc                                                   20


<210>  6270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6270
gaucagacac ccuuugguag                                                   20


<210>  6271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6271
accaaagggu gucugaucag                                                   20


<210>  6272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6272
aguaucuucg gcgcacauca                                                   20


<210>  6273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6273
gcgcacauca guguaugggu                                                   20


<210>  6274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6274
uaaugucuug uuauaaagca                                                   20


<210>  6275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6275
ugucuugaca aucuaaaaca                                                   20


<210>  6276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6276
augcuaagca guacucuaaa                                                   20


<210>  6277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6277
guugugggcc uagcuggauc                                                   20


<210>  6278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6278
aagugagaga uccagcuagg                                                   20


<210>  6279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6279
cuaauuaguc acaccucuac                                                   20


<210>  6280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6280
cuuauguaga ggugugacua                                                   20


<210>  6281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6281
uuuucacuua uguagaggug                                                   20


<210>  6282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6282
gauuuccuuu ucacuuaugu                                                   20


<210>  6283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6283
aaaacuauuu uuaagguuca                                                   20


<210>  6284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6284
auuucaguau ucauuacuuu                                                   20


<210>  6285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6285
guauucauua cuuucucucu                                                   20


<210>  6286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6286
uuacuuucuc ucugaugcuc                                                   20


<210>  6287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6287
cucugaugcu cauuucaucc                                                   20


<210>  6288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6288
uccuuuuaac uuacucccag                                                   20


<210>  6289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6289
auuaguuuuu uuauuuaucg                                                   20


<210>  6290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6290
ccuccaaagc auucauacuc                                                   20


<210>  6291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6291
uacuccaggg ucucgucauu                                                   20


<210>  6292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6292
ucuauaacug ugucauuaaa                                                   20


<210>  6293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6293
auaacugugu cauuaaauuu                                                   20


<210>  6294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6294
uuuuccacac ccucuagaac                                                   20


<210>  6295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6295
acacccucua gaacccagag                                                   20


<210>  6296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6296
agagggugug gaaaaggaaa                                                   20


<210>  6297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6297
gcccuccccu gcucuccguu                                                   20


<210>  6298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6298
ugaggcagca cuuacucacu                                                   20


<210>  6299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6299
uuaaggacag gcgguaagag                                                   20


<210>  6300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6300
uucauuaagg acaggcggua                                                   20


<210>  6301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6301
uaguuuucug ugagggcaac                                                   20


<210>  6302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6302
gugagggcaa ccuuuuuucg                                                   20


<210>  6303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6303
uggggauccu ccaccgcccu                                                   20


<210>  6304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6304
cccauuuucc ccaacuucag                                                   20


<210>  6305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6305
ccaacuucag aagaagaauc                                                   20


<210>  6306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6306
gaagaagaau cuuggcgagc                                                   20


<210>  6307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6307
gaaguugggg aaaaugggcg                                                   20


<210>  6308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6308
ucugaaguug gggaaaaugg                                                   20


<210>  6309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6309
ucuucugaag uuggggaaaa                                                   20


<210>  6310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6310
ugaaacugug uaaggcucca                                                   20


<210>  6311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6311
ggaauggcuc gccaagauuc                                                   20


<210>  6312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6312
cuggaugcua aacauggagc                                                   20


<210>  6313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6313
acauaguuuc ccuggaugcu                                                   20


<210>  6314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6314
uuuccucacu cacuucuuuu                                                   20


<210>  6315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6315
caaccauuca uuuccucacu                                                   20


<210>  6316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6316
ggaagaaaaa aaguuacccu                                                   20


<210>  6317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6317
ugaaauuuuu cacaaccauu                                                   20


<210>  6318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6318
uccugaaauu uuucacaacc                                                   20


<210>  6319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6319
ucauauuuaa uggagcgucc                                                   20


<210>  6320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6320
cagucaaacc caaaucucau                                                   20


<210>  6321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6321
ccuaaugaga uuuggguuug                                                   20


<210>  6322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6322
cuguuauucu cuaaagaaaa                                                   20


<210>  6323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6323
cuaaagaaaa aaaaaaggaa                                                   20


<210>  6324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6324
uuagagaaua acagugaaaa                                                   20


<210>  6325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6325
uuuuuuuuuu cuuuagagaa                                                   20


<210>  6326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6326
gauuugcucu uuuuccuuuu                                                   20


<210>  6327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6327
uuacacuuuu cacaguagua                                                   20


<210>  6328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6328
caguaguacg cauuacuucc                                                   20


<210>  6329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6329
uucuagaacu ucuccucuaa                                                   20


<210>  6330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6330
agaacuucuc cucuaacaaa                                                   20


<210>  6331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6331
agaaggaagu aaugcguacu                                                   20


<210>  6332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6332
ccucuaacaa auugguccaa                                                   20


<210>  6333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6333
uuggaccaau uuguuagagg                                                   20


<210>  6334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6334
aaacucugac aagaagucac                                                   20


<210>  6335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6335
ugucagaguu uggaaauuuc                                                   20


<210>  6336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6336
uggcucucaa ucuaggagug                                                   20


<210>  6337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6337
ucacgcucau aucugauuag                                                   20


<210>  6338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6338
cgcucauauc ugauuaggaa                                                   20


<210>  6339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6339
uaaucagaua ugagcgugaa                                                   20


<210>  6340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6340
guuauuuccu aaucagauau                                                   20


<210>  6341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6341
auuguugauu guggguuuuc                                                   20


<210>  6342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6342
auuaucauaa uaccuaagcu                                                   20


<210>  6343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6343
uaauugucac aaaguggcau                                                   20


<210>  6344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6344
uaauuuuagg caauucuuaa                                                   20


<210>  6345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6345
augaauauuu ucuuaagccc                                                   20


<210>  6346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6346
uugaaauuca uaauuuuagg                                                   20


<210>  6347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6347
uaagcccaca aagaaauuuu                                                   20


<210>  6348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6348
uugugggcuu aagaaaauau                                                   20


<210>  6349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6349
ccuucuggaa guagaaagca                                                   20


<210>  6350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6350
ggaaguagaa agcaaagaaa                                                   20


<210>  6351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6351
agaaggagaa aaaauuucuu                                                   20


<210>  6352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6352
aagucucuua acaaaugcaa                                                   20


<210>  6353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6353
aaaggaugau cauuuuuccu                                                   20


<210>  6354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6354
ugugucggug auaucuucac                                                   20


<210>  6355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6355
cucaccugug aggacagucu                                                   20


<210>  6356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6356
gaucagagua gaugcccuga                                                   20


<210>  6357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6357
gggcaucuac ucugaucaga                                                   20


<210>  6358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6358
uaaaaauuug gucucucccc                                                   20


<210>  6359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6359
guuggaauga aaaguuacag                                                   20


<210>  6360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6360
aacagaaaau ggggagagac                                                   20


<210>  6361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6361
uuccaacaga aaauggggag                                                   20


<210>  6362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6362
ggaggcauca cuuaaaacug                                                   20


<210>  6363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6363
guauacucau aaguucagga                                                   20


<210>  6364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6364
gguaguauca gcugugguga                                                   20


<210>  6365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6365
ugcaccucag ccucccgagu                                                   20


<210>  6366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6366
cucuaacucc cucaaacucu                                                   20


<210>  6367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6367
uccaucugau caaugagacu                                                   20


<210>  6368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6368
uuacuagucu cauugaucag                                                   20


<210>  6369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6369
uaugcauccu gcuguucucu                                                   20


<210>  6370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6370
cucacauaaa guucuuuauu                                                   20


<210>  6371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6371
uuauuccaca ucuugaaaau                                                   20


<210>  6372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6372
acaucuugaa aaucuauaua                                                   20


<210>  6373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6373
agauguggaa uaaagaacuu                                                   20


<210>  6374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6374
uuuaaaaaca uuuaauuuuu                                                   20


<210>  6375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6375
gaauguggua gaaagggaac                                                   20


<210>  6376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6376
accacauuca gaaauugcua                                                   20


<210>  6377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6377
cuuucuacca cauucagaaa                                                   20


<210>  6378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6378
uguucccuuu cuaccacauu                                                   20


<210>  6379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6379
cuauuaggau guggacauuu                                                   20


<210>  6380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6380
agugaaguga gacuagcuug                                                   20


<210>  6381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6381
uuauuuaaag acauuaguga                                                   20


<210>  6382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6382
cuaaugucuu uaaauaaaga                                                   20


<210>  6383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6383
ccugacccug ugccgauuuc                                                   20


<210>  6384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6384
uaucauuccc cugacccugu                                                   20


<210>  6385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6385
aagaacuaaa auaagaauca                                                   20


<210>  6386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6386
uugaaauauu uguucauauc                                                   20


<210>  6387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6387
uauuuuaguu cuuugaaaua                                                   20


<210>  6388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6388
aaauaauuaa gaugagcaaa                                                   20


<210>  6389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6389
uaggaauuga augacuauuc                                                   20


<210>  6390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6390
uaggaauuug cucaucuuaa                                                   20


<210>  6391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6391
auuccuagga auuugcucau                                                   20


<210>  6392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6392
caacauucua augauuugaa                                                   20


<210>  6393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6393
cccaguaacu cuugagauuu                                                   20


<210>  6394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6394
aaaaauucuc agguacauag                                                   20


<210>  6395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6395
cagguacaua guacugcagc                                                   20


<210>  6396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6396
auuaaauguc caaagagaga                                                   20


<210>  6397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6397
guggaugaug acacagacaa                                                   20


<210>  6398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6398
gugcagucau uacuuucagu                                                   20


<210>  6399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6399
uuucugugca gucauuacuu                                                   20


<210>  6400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6400
agcuugauau guuucuuuuc                                                   20


<210>  6401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6401
cuacaggaaa uaagcguagc                                                   20


<210>  6402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6402
uguagagaac cugguauuac                                                   20


<210>  6403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6403
auguguacug ggcuacgcuu                                                   20


<210>  6404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6404
aaaauacuaa aacugucagu                                                   20


<210>  6405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6405
auaaaguuac ugacaguuuu                                                   20


<210>  6406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6406
aaaaucacau uaggucaagu                                                   20


<210>  6407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6407
ggagcuacua aagaauugca                                                   20


<210>  6408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6408
uuaguagcuc cugaaaugug                                                   20


<210>  6409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6409
auccuuuuug guacgauaga                                                   20


<210>  6410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6410
uuuuucuauc cuuuuuggua                                                   20


<210>  6411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6411
agcagcugua uaugcaaccu                                                   20


<210>  6412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6412
uauaacaagu ugcaccacca                                                   20


<210>  6413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6413
cagccccaca aacccugaac                                                   20


<210>  6414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6414
ggguuugugg ggcugagaaa                                                   20


<210>  6415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6415
cccaguggau agcaggucca                                                   20


<210>  6416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6416
aguaccuucc cccaguggau                                                   20


<210>  6417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6417
ucucuuuucc aguaccuucc                                                   20


<210>  6418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6418
auuccucucu uuuccaguac                                                   20


<210>  6419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6419
ccucugcugu uucuauuccu                                                   20


<210>  6420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6420
ucuccucugc uguuucuauu                                                   20


<210>  6421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6421
uaacaugcug gauggguaaa                                                   20


<210>  6422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6422
ugaaguaccu cugcagaugc                                                   20


<210>  6423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6423
ugaacauagg uuuugccagc                                                   20


<210>  6424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6424
acaaauauug auuaaauacc                                                   20


<210>  6425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6425
aucugccagg cacugugcau                                                   20


<210>  6426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6426
ugguaaucac uucguagacu                                                   20


<210>  6427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6427
uuuuagagaa gguaacauuc                                                   20


<210>  6428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6428
cuaaaaggaa uuacaauaug                                                   20


<210>  6429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6429
acauggcacu ucuucaagug                                                   20


<210>  6430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6430
ucaaguggaa aaggauacug                                                   20


<210>  6431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6431
aguggaaaag gauacuguaa                                                   20


<210>  6432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6432
acuugaagaa gugccauguu                                                   20


<210>  6433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6433
aaguguaaaa uuacaguauc                                                   20


<210>  6434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6434
uuaacaucag acauauacuu                                                   20


<210>  6435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6435
aagaccuaau uaacaccgaa                                                   20


<210>  6436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6436
guguuaauua ggucuuagaa                                                   20


<210>  6437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6437
aacuuaugag agcccacauu                                                   20


<210>  6438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6438
aaccuauuuu uucagugacu                                                   20


<210>  6439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6439
caguaaaaag uagcauucca                                                   20


<210>  6440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6440
aguugcuugg uaguuauucu                                                   20


<210>  6441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6441
uaauauauuc aguauauuag                                                   20


<210>  6442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6442
guauauuaga gugauacuau                                                   20


<210>  6443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6443
aaaaaaauua aguucaucaa                                                   20


<210>  6444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6444
ucaacgucua gaaaaccuac                                                   20


<210>  6445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6445
agacguugau gaacuuaauu                                                   20


<210>  6446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6446
augcaucacc agccugaccc                                                   20


<210>  6447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6447
uuuauaauaa uuugaagauu                                                   20


<210>  6448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6448
aauuauuaua aaagaacugc                                                   20


<210>  6449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6449
aaucuucaaa uuauuauaaa                                                   20


<210>  6450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6450
ccuucaaauc uucaaauuau                                                   20


<210>  6451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6451
uaggcugcca aucggcuauu                                                   20


<210>  6452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6452
cuguacuaca ccuagaaaca                                                   20


<210>  6453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6453
agguguagua cagcgaauag                                                   20


<210>  6454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6454
acaaugaaua aucuacuuaa                                                   20


<210>  6455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6455
uuguugaaau ugacuugugu                                                   20


<210>  6456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6456
acuguugauu uaguuuaaug                                                   20


<210>  6457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6457
uuucaacugu ugauuuaguu                                                   20


<210>  6458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6458
acuuucauuu caacuguuga                                                   20


<210>  6459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6459
ucaaacauac uuaagucagg                                                   20


<210>  6460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6460
uaggaugaca gcgauaaaau                                                   20


<210>  6461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6461
uuugcugcca uccuaagauc                                                   20


<210>  6462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6462
ggguuuuaca gcuuucuuuu                                                   20


<210>  6463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6463
uaaccaguga ucccucagua                                                   20


<210>  6464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6464
guguauccuu ccuaaccagu                                                   20


<210>  6465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6465
cucagagguu ggcuauccuc                                                   20


<210>  6466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6466
cuaaguguuu cacucagagg                                                   20


<210>  6467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6467
uaucugaacu ucaggguugc                                                   20


<210>  6468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6468
gauaagaagc aaaggacagu                                                   20


<210>  6469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6469
ggguugcaaa ggacaguaag                                                   20


<210>  6470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6470
uacuguccuu ugcaacccug                                                   20


<210>  6471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6471
uuucuuacug uccuuugcaa                                                   20


<210>  6472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6472
guguauuuua aaucucuuuc                                                   20


<210>  6473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6473
uccuugaagg uuuugguggg                                                   20


<210>  6474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6474
uugaagguuu uggugggaaa                                                   20


<210>  6475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6475
aggaagaaag agauuuaaaa                                                   20


<210>  6476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6476
caccaaaacc uucaaggaag                                                   20


<210>  6477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6477
cagucuuuuc ccaccaaaac                                                   20


<210>  6478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6478
guacaauggg gagggaugaa                                                   20


<210>  6479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6479
ucccucccca uuguacugaa                                                   20


<210>  6480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6480
uuuuuuaauc aaggcacugu                                                   20


<210>  6481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6481
uaccuaaaac agauuuugcu                                                   20


<210>  6482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6482
cuacuuaaag uugccucauu                                                   20


<210>  6483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6483
acaaaauacu gcuuauuaug                                                   20


<210>  6484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6484
auaaccacug aaauuguaca                                                   20


<210>  6485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6485
gugguuauug aaauggacaa                                                   20


<210>  6486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6486
uguacaauuu cagugguuau                                                   20


<210>  6487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6487
cuauaaacag caaauaguuu                                                   20


<210>  6488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6488
ucaggauuac ucaauuaacu                                                   20


<210>  6489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6489
ggauuacuca auuaacucug                                                   20


<210>  6490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6490
ugagaaagga acaaaguuag                                                   20


<210>  6491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6491
caugaaaacc agaguuaauu                                                   20


<210>  6492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6492
uuucucauga aaaccagagu                                                   20


<210>  6493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6493
uuugcuccaa aucuaacuaa                                                   20


<210>  6494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6494
uccuaccucc aagaguauaa                                                   20


<210>  6495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6495
aauuuguacc cauaaaacua                                                   20


<210>  6496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6496
aaaauuacua cuguaauaaa                                                   20


<210>  6497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6497
ucauuuagug gauaauauag                                                   20


<210>  6498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6498
uuuaguggau aauauaggau                                                   20


<210>  6499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6499
aucugugagu cuguguaucc                                                   20


<210>  6500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6500
gucccaaaag auuuuguuaa                                                   20


<210>  6501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6501
aauuagaauu uuuaccaaaa                                                   20


<210>  6502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6502
aauuugaaac uucaguccca                                                   20


<210>  6503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6503
guuuugguaa aaauucuaau                                                   20


<210>  6504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6504
auacuuugga ugaaaguccu                                                   20


<210>  6505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6505
uccaaaguau ggaaaaugca                                                   20


<210>  6506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6506
ccagcuggca gugccgccau                                                   20


<210>  6507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6507
agaagcucgg aaaaggaagu                                                   20


<210>  6508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6508
agaauuauuu uaaauaguca                                                   20


<210>  6509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6509
gagcuucuag aauuauuuua                                                   20


<210>  6510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6510
uuuuccgagc uucuagaauu                                                   20


<210>  6511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6511
ucacucauua aaccauuguu                                                   20


<210>  6512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6512
agguucauca cucauuaaac                                                   20


<210>  6513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6513
uguugaagau gaacacauau                                                   20


<210>  6514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6514
acaugaauau uaugcucuau                                                   20


<210>  6515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6515
ucuucaacau gaauauuaug                                                   20


<210>  6516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6516
aagauccuau cuugcacuuu                                                   20


<210>  6517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6517
cuguauugua agcccauaaa                                                   20


<210>  6518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6518
cuuuagaaac agaagugcca                                                   20


<210>  6519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6519
aaagugaaag cuugacuccu                                                   20


<210>  6520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6520
guuucuaaag ugaaagcuug                                                   20


<210>  6521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6521
gccuuguggu guccuuggca                                                   20


<210>  6522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6522
cucucugguu aagaaucacu                                                   20


<210>  6523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6523
uaaccagaga gagaaaggca                                                   20


<210>  6524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6524
auguaucccc aguagccaag                                                   20


<210>  6525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6525
uggcuacugg ggauacauag                                                   20


<210>  6526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6526
uuugucuucu gaauacaauu                                                   20


<210>  6527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6527
ccuaggguac acauguaauu                                                   20


<210>  6528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6528
gaugagaauc acccuuaaaa                                                   20


<210>  6529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6529
caucugaaga ggcagccccu                                                   20


<210>  6530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6530
uuuaagggug auucucaucu                                                   20


<210>  6531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6531
uacuguguga agggucaauu                                                   20


<210>  6532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6532
cacaguagga aauuguccgu                                                   20


<210>  6533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6533
auggaacacu uggcaucuau                                                   20


<210>  6534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6534
auggaaaauu gacccuucac                                                   20


<210>  6535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6535
cacuuacaca caguacuggc                                                   20


<210>  6536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6536
gugcucgguu auugccagua                                                   20


<210>  6537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6537
ucagugcucg guuauugcca                                                   20


<210>  6538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6538
uuuucugccc cacagaguga                                                   20


<210>  6539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6539
gccccacaga gugaaagaag                                                   20


<210>  6540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6540
cucugugggg cagaaaagga                                                   20


<210>  6541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6541
uucacucugu ggggcagaaa                                                   20


<210>  6542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6542
cuggucucac auucagcugu                                                   20


<210>  6543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6543
gcuguacgau uagguucaaa                                                   20


<210>  6544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6544
aaguuaucca gccaaguaau                                                   20


<210>  6545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6545
agcaucguag cugggcugau                                                   20


<210>  6546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6546
gaagcuaaga aggaaaaaaa                                                   20


<210>  6547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6547
gaaauggagc aguuaaggau                                                   20


<210>  6548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6548
uagcuucaga aauggagcag                                                   20


<210>  6549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6549
uucuuagcuu cagaaaugga                                                   20


<210>  6550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6550
uuguaaugga uuuuuuuuuu                                                   20


<210>  6551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6551
uucuuuguaa uggauuuuuu                                                   20


<210>  6552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6552
ccugccucag ccucccgagu                                                   20


<210>  6553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6553
agcaauucuc cugccucagc                                                   20


<210>  6554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6554
uggguucaag caauucuccu                                                   20


<210>  6555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6555
uaagugucug ucaaaaacag                                                   20


<210>  6556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6556
ucaguuucgu aagugucugu                                                   20


<210>  6557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6557
uuuagacuua ggugcuggga                                                   20


<210>  6558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6558
cagcaccuaa gucuaaaaga                                                   20


<210>  6559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6559
uuugagaaac uauucuauuu                                                   20


<210>  6560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6560
caaaagaagc aaaucucuuu                                                   20


<210>  6561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6561
auuucuucuu acaggguauu                                                   20


<210>  6562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6562
ucuuacaggg uauuugaaca                                                   20


<210>  6563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6563
uacaggguau uugaacaacu                                                   20


<210>  6564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6564
aauacccugu aagaagaaau                                                   20


<210>  6565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6565
uuuuuaccuc uggccuucag                                                   20


<210>  6566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6566
gagguauuuu uuuuccuccu                                                   20


<210>  6567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6567
uccuggucuu gacguucuuu                                                   20


<210>  6568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6568
uuaccaauug cuauuuuugu                                                   20


<210>  6569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6569
uguaagcuga agcaaauucu                                                   20


<210>  6570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6570
gcuuacagga aauuaauaaa                                                   20


<210>  6571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6571
uugugaagag cggagaauaa                                                   20


<210>  6572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6572
caaagaauuu gcuucagcuu                                                   20


<210>  6573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6573
ccgcucuuca caaagaauuu                                                   20


<210>  6574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6574
gaucaugagu uuguuauucu                                                   20


<210>  6575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6575
aaaguacauu uacauuauuu                                                   20


<210>  6576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6576
cuccggugua gucuguuaua                                                   20


<210>  6577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6577
caauaguuuc guaucagugu                                                   20


<210>  6578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6578
uaucagugua auuaaaauau                                                   20


<210>  6579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6579
caauucauua augacugguu                                                   20


<210>  6580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6580
uuaaugacug guuauguaac                                                   20


<210>  6581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6581
ccagccccuc uccccuacau                                                   20


<210>  6582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6582
guuuuuuaga cuguuaucuc                                                   20


<210>  6583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6583
guuacuaaua agaggcugau                                                   20


<210>  6584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6584
aaucagccuc uuauuaguaa                                                   20


<210>  6585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6585
uuguaagaac aaauucauaa                                                   20


<210>  6586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6586
uacaaggaaa augcuuuuua                                                   20


<210>  6587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6587
uaaaacaagu gagcaagaua                                                   20


<210>  6588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6588
auauuuuagc aagaagcaua                                                   20


<210>  6589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6589
ugcuaaaaua uggaauuuga                                                   20


<210>  6590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6590
guuacuauau cuguauuagu                                                   20


<210>  6591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6591
cucucuuuac accguuauuu                                                   20


<210>  6592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6592
cuuuuaacuu uuaguuuucu                                                   20


<210>  6593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6593
aacuucuaaa augcuuacua                                                   20


<210>  6594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6594
aaaaugcuua cuauaguauu                                                   20


<210>  6595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6595
aauacuauag uaagcauuuu                                                   20


<210>  6596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6596
auauguuugu guauaugcgu                                                   20


<210>  6597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6597
uuuaauccuc agacuggccu                                                   20


<210>  6598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6598
gcuuaaaucu ugaugguaaa                                                   20


<210>  6599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6599
gccaaaacuu aaaaauuaug                                                   20


<210>  6600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6600
uagacaucug gaauguuaaa                                                   20


<210>  6601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6601
agaugucuaa gaaagaaguc                                                   20


<210>  6602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6602
guuuuaacau uccagauguc                                                   20


<210>  6603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6603
aaauaauauu uauguagaag                                                   20


<210>  6604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6604
acauaaauau uauuuugaaa                                                   20


<210>  6605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6605
ggccccugua ucccggcuuc                                                   20


<210>  6606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6606
ugacuuuuuu uaauaccucu                                                   20


<210>  6607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6607
uugauccauu cuugacuuuu                                                   20


<210>  6608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6608
cucugguuuc uuugauccau                                                   20


<210>  6609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6609
aauuuucccu cugguuucuu                                                   20


<210>  6610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6610
uuugucuuaa uauauuuucu                                                   20


<210>  6611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6611
uuugauauuu cccauaauuu                                                   20


<210>  6612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6612
aucucauaac acuucuuuug                                                   20


<210>  6613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6613
aaaaaccagc uccucgauuc                                                   20


<210>  6614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6614
cugauuuuuu gaaggguucu                                                   20


<210>  6615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6615
aaaaaucagu gaaucgagga                                                   20


<210>  6616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6616
ucgugucucu aucuucuuca                                                   20


<210>  6617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6617
ugucucuauc uucuucaguu                                                   20


<210>  6618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6618
ucaguucugc ucugaucuua                                                   20


<210>  6619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6619
guucugcucu gaucuuaguu                                                   20


<210>  6620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6620
gcucugaucu uaguuauuuu                                                   20


<210>  6621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6621
gcuagcuuuu gaauuuguuu                                                   20


<210>  6622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6622
aaagcuagca gaaggcaaaa                                                   20


<210>  6623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6623
cuaguucuuu uaauugugau                                                   20


<210>  6624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6624
uuuaauugug auguuagggu                                                   20


<210>  6625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6625
ugcuuucucc ugugggcauu                                                   20


<210>  6626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6626
ccugugggca uuuagugcua                                                   20


<210>  6627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6627
gguacguugu gucuuuguuc                                                   20


<210>  6628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6628
cauugguuuc aaauaacuua                                                   20


<210>  6629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6629
aauaacuuau uuauuucugc                                                   20


<210>  6630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6630
gccuuaauuu cauuauuuac                                                   20


<210>  6631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6631
uuauuuaccc aguagucauu                                                   20


<210>  6632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6632
ggagcagguu guucaguuuc                                                   20


<210>  6633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6633
guuuccaugu aguugugcga                                                   20


<210>  6634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6634
auguaguugu gcgauuuuga                                                   20


<210>  6635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6635
cucaaaaucg cacaacuaca                                                   20


<210>  6636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6636
uaauccugag uucuaauuug                                                   20


<210>  6637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6637
acaccacauu gcacuuacuc                                                   20


<210>  6638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6638
uuucaacacc acauugcacu                                                   20


<210>  6639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6639
guugauuugg gguggagagu                                                   20


<210>  6640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6640
guagaugucu auuaggucug                                                   20


<210>  6641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6641
aguccugaau auccuuauua                                                   20


<210>  6642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6642
ugguuuaguc uugggagggu                                                   20


<210>  6643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6643
ucuugguuua gucuugggag                                                   20


<210>  6644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6644
acuucuucuu gguuuagucu                                                   20


<210>  6645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6645
gggauucgac uucuucuugg                                                   20


<210>  6646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6646
gaaauggagg caguaauuaa                                                   20


<210>  6647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6647
gaacuuguua uuggucuauu                                                   20


<210>  6648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6648
cagcugaauu cuaccagagg                                                   20


<210>  6649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6649
gcugugaauc caucuggucc                                                   20


<210>  6650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6650
accagaggua caaagaggag                                                   20


<210>  6651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6651
uucugaaacu auuccaagca                                                   20


<210>  6652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6652
gaaacuauuc caagcaacag                                                   20


<210>  6653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6653
gaaggaaugg uaccagcucc                                                   20


<210>  6654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6654
aagcaacaga aaaagaggga                                                   20


<210>  6655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6655
guugcuugga auaguuucag                                                   20


<210>  6656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6656
aauacuaugu uaaauaagag                                                   20


<210>  6657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6657
ggccagggca aucaggcaag                                                   20


<210>  6658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6658
cuugccugau ugcccuggcc                                                   20


<210>  6659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6659
uucucuugcc ugauugcccu                                                   20


<210>  6660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6660
gauaggaaga caggaaguca                                                   20


<210>  6661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6661
uaucugaaua cccuuuauuu                                                   20


<210>  6662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6662
ugucuuccua ucugaauacc                                                   20


<210>  6663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6663
aaauauacaa ucaugucauc                                                   20


<210>  6664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6664
cucaggccaa aaucuccuua                                                   20


<210>  6665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6665
gcaaagucuc aggauacaaa                                                   20


<210>  6666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6666
uauacacgaa uaauagacaa                                                   20


<210>  6667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6667
uguauaggaa uguuugugau                                                   20


<210>  6668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6668
cucaugauuu gucuauuauu                                                   20


<210>  6669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6669
caauuacuac aaagagaaaa                                                   20


<210>  6670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6670
cuuuguagua auugugaaug                                                   20


<210>  6671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6671
uagguauuuu uuucucuuug                                                   20


<210>  6672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6672
ucaaggagaa cuacaaacca                                                   20


<210>  6673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6673
aggagaacua caaaccacug                                                   20


<210>  6674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6674
ccuugaagaa guccuccaca                                                   20


<210>  6675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6675
uugagcagug guuuguaguu                                                   20


<210>  6676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6676
auuuguuugu guccucucuu                                                   20


<210>  6677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6677
augcucgugc ccaggaagaa                                                   20


<210>  6678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6678
ugggcacgag cauggaaugu                                                   20


<210>  6679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6679
uccugggcac gagcauggaa                                                   20


<210>  6680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6680
caacauugau ucuuccuggg                                                   20


<210>  6681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6681
acgcuauccc caucaagcua                                                   20


<210>  6682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6682
ucacagaauu agagaaaacu                                                   20


<210>  6683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6683
cagaauuaga gaaaacuacu                                                   20


<210>  6684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6684
gugaagaaag ucagugguag                                                   20


<210>  6685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6685
cuaauucugu gaagaaaguc                                                   20


<210>  6686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6686
uauggaacca aaacagaacc                                                   20


<210>  6687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6687
auaugaaauu uaaaguaguu                                                   20


<210>  6688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6688
guuuugguuc cauaugaaau                                                   20


<210>  6689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6689
uuuugcuuag gauugucuug                                                   20


<210>  6690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6690
aacuauacua caaggcuaca                                                   20


<210>  6691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6691
uguuuuuaau guaagcauuu                                                   20


<210>  6692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6692
auugacaacc uaacuuuaca                                                   20


<210>  6693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6693
uuagguguaa aguuagguug                                                   20


<210>  6694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6694
aguuccuuag guguaaaguu                                                   20


<210>  6695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6695
uuuucuaguu ccuuaggugu                                                   20


<210>  6696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6696
ucuuuuucua guuccuuagg                                                   20


<210>  6697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6697
uuuuacuacc uuuaaguuug                                                   20


<210>  6698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6698
uuccuuuuac uaccuuuaag                                                   20


<210>  6699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6699
acucuaaucu uuguuauuuc                                                   20


<210>  6700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6700
uuauuuuauu uauuuccacu                                                   20


<210>  6701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6701
uuuugguauu guuuugccau                                                   20


<210>  6702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6702
uugauuuuuu uuuuucuuuu                                                   20


<210>  6703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6703
aagaggcaac uuuugguuuc                                                   20


<210>  6704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6704
uucaaagagg caacuuuugg                                                   20


<210>  6705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6705
cccuuuuuug uguuagucua                                                   20


<210>  6706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6706
gaguuuagua auuugauccu                                                   20


<210>  6707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6707
uuucugaguu uaguaauuug                                                   20


<210>  6708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6708
guaaaauugg uaguuaugua                                                   20


<210>  6709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6709
auuucuguaa aauugguagu                                                   20


<210>  6710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6710
uuuuuuuuuu uuggauuacc                                                   20


<210>  6711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6711
uuucuuuuuu uuuuuuugga                                                   20


<210>  6712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6712
uuucuuuucu uuuuuuuuuu                                                   20


<210>  6713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6713
uuguugggag uuuguuuuuc                                                   20


<210>  6714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6714
cuggugaauu cuaccaauau                                                   20


<210>  6715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6715
ccagugaagc caucuggucc                                                   20


<210>  6716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6716
accaauauuu aaagaauuac                                                   20


<210>  6717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6717
uuaaauauug guagaauuca                                                   20


<210>  6718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6718
gccagagcaa uuaggcaaga                                                   20


<210>  6719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6719
ugccuaauug cucuggcuga                                                   20


<210>  6720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6720
uuuucuugcc uaauugcucu                                                   20


<210>  6721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6721
auuuggaugu cuuuuaguuc                                                   20


<210>  6722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6722
ccugccucag ccucccgagu                                                   20


<210>  6723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6723
cgccauucuc cugccucagc                                                   20


<210>  6724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6724
cggguucacg ccauucuccu                                                   20


<210>  6725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6725
cggcuucccg gguucacgcc                                                   20


<210>  6726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6726
uuuuuuuuuu uuuuuuuuuu                                                   20


<210>  6727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6727
guuugaucau uguuagugua                                                   20


<210>  6728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6728
uuuucaguuu gaucauuguu                                                   20


<210>  6729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6729
acuuacaaua gcaucaaaaa                                                   20


<210>  6730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6730
uaaguauuuu auuauuuuug                                                   20


<210>  6731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6731
uuaaguuggu uccuaaguau                                                   20


<210>  6732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6732
cuguacaagu cuuuuguuuc                                                   20


<210>  6733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6733
gcaauguuug uagauuucac                                                   20


<210>  6734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6734
uucagcaaug uuuguagauu                                                   20


<210>  6735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6735
aggauugaaa gacaaaaucu                                                   20


<210>  6736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6736
auccuugaac acaagauguc                                                   20


<210>  6737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6737
uggcuaugac agcaaaaaac                                                   20


<210>  6738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6738
cuuuaguuac cuguguuuuu                                                   20


<210>  6739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6739
caguuuggug auugacuuuu                                                   20


<210>  6740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6740
uauauagaaa auuuuaauuu                                                   20


<210>  6741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6741
auauaggaaa aaaugccuca                                                   20


<210>  6742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6742
auuuuuauua ccuaccucug                                                   20


<210>  6743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6743
aggcguaauc cucacggcuc                                                   20


<210>  6744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6744
ucuaggcgua auccucacgg                                                   20


<210>  6745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6745
gcacaucugg augcgcugau                                                   20


<210>  6746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6746
ccggguugcc ugugaucagc                                                   20


<210>  6747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6747
gauucgccgg guugccugug                                                   20


<210>  6748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6748
ugucuguccu uugcugcuga                                                   20


<210>  6749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6749
cauuacuuac aaaacuccuu                                                   20


<210>  6750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6750
gcucggauca ccaagugcug                                                   20


<210>  6751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6751
ucauugauau ucugcucgga                                                   20


<210>  6752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6752
auaacuugcc cuguguugcu                                                   20


<210>  6753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6753
uauuagcauc uuucuauaac                                                   20


<210>  6754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6754
ucuuauuagc aucuuucuau                                                   20


<210>  6755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6755
cacacccaca ucccccauuu                                                   20


<210>  6756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6756
aauuuugauu aauuucuuaa                                                   20


<210>  6757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6757
uaagcucaac uuaagcauaa                                                   20


<210>  6758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6758
ccaagcaaaa gccaaaucuu                                                   20


<210>  6759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6759
caguucacca agcaaaagcc                                                   20


<210>  6760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6760
gguggcuucu caguucacca                                                   20


<210>  6761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6761
cuacucagca accagggugg                                                   20


<210>  6762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6762
gccuugcagu uuauucucua                                                   20


<210>  6763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6763
ugcuucugcc uugcaguuua                                                   20


<210>  6764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6764
uagauaaggu cccauugguc                                                   20


<210>  6765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6765
uccuagauaa ggucccauug                                                   20


<210>  6766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6766
uuacauuucu uccuagauaa                                                   20


<210>  6767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6767
caacagaaac uuggccuuuc                                                   20


<210>  6768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6768
guugggaauu cuuuacauuu                                                   20


<210>  6769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6769
cugaaagaga uuaaucacaa                                                   20


<210>  6770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6770
gggaaaggcc aaguuucugu                                                   20


<210>  6771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6771
gagccagcaa cuggguaugc                                                   20


<210>  6772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6772
uguuacgugc cuacagcuuc                                                   20


<210>  6773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6773
acaacagucu guauccacca                                                   20


<210>  6774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6774
cgcaugcagg gcuacugguu                                                   20


<210>  6775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6775
ccuucacuuc cagagcugca                                                   20


<210>  6776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6776
cuuccagagc ugcaauugcu                                                   20


<210>  6777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6777
agagcugcaa uugcuuccug                                                   20


<210>  6778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6778
ugaaaacagg uaagcagaaa                                                   20


<210>  6779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6779
ggaagcaauu gcagcucugg                                                   20


<210>  6780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6780
gcuuaccugu uuucaggaag                                                   20


<210>  6781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6781
uguaggaucc acaguaaauu                                                   20


<210>  6782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6782
uuaaaacaca uuugcaggca                                                   20


<210>  6783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6783
caaggcaaaa cuaauuucag                                                   20


<210>  6784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6784
ggcgauagaa gugaaaauag                                                   20


<210>  6785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6785
aaaauagaga uugagcagga                                                   20


<210>  6786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6786
ugcucaaucu cuauuuuaga                                                   20


<210>  6787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6787
cagcuuuauu uggucuuccu                                                   20


<210>  6788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6788
uuaggccucu uuaaaauaua                                                   20


<210>  6789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6789
ugacacuuuu auacucagcu                                                   20


<210>  6790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6790
ucaagcucug uauacacuua                                                   20


<210>  6791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6791
cuugcuugug agcaugagua                                                   20


<210>  6792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6792
guguguaggu uugccagagu                                                   20


<210>  6793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6793
uaugguuauu ucuuacccag                                                   20


<210>  6794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6794
uacccagugu ucucauuacu                                                   20


<210>  6795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6795
cauuacuguc ucuuuuuaau                                                   20


<210>  6796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6796
gguacugauu aaaaagagac                                                   20


<210>  6797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6797
aauuccagca ggacacaggg                                                   20


<210>  6798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6798
aaacagacuc agcaguucag                                                   20


<210>  6799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6799
agcaggacac agggaauuac                                                   20


<210>  6800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6800
cuguguccug cuggaauucg                                                   20


<210>  6801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6801
uuaauuggcu ggcuacuccc                                                   20


<210>  6802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6802
ugagauuguc augggcugcg                                                   20


<210>  6803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6803
acuguggcuu gcuucaugag                                                   20


<210>  6804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6804
cuucuacugu ggcuugcuuc                                                   20


<210>  6805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6805
auugucuaaa gaauggaaca                                                   20


<210>  6806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6806
uuagacaaug gaaguaagug                                                   20


<210>  6807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6807
auucuuuaga caauggaagu                                                   20


<210>  6808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6808
cauaauacuu guuccauucu                                                   20


<210>  6809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6809
agacauuuua gucccucuua                                                   20


<210>  6810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6810
ucaacccuaa uagaagaccu                                                   20


<210>  6811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6811
auuaggguug aggaaaucau                                                   20


<210>  6812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6812
gggguaccac auaaggacau                                                   20


<210>  6813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6813
gaaugggcgg gaagaaagug                                                   20


<210>  6814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6814
gaaaugucag ccggcagaca                                                   20


<210>  6815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6815
cgcccauucc gaaaugucag                                                   20


<210>  6816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6816
ucccgcccau uccgaaaugu                                                   20


<210>  6817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6817
auaccaucuu uggugagguc                                                   20


<210>  6818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6818
ucuaauaacg ugggcauugu                                                   20


<210>  6819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6819
uuuuaagauu uuuacuuguc                                                   20


<210>  6820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6820
gaguccauuc auacuauuua                                                   20


<210>  6821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6821
uacuauuuaa aaacaugauu                                                   20


<210>  6822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6822
aucugucuac agcuugcaag                                                   20


<210>  6823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6823
uagucuacuu cugaugggau                                                   20


<210>  6824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6824
gaugggaugg agucucucug                                                   20


<210>  6825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6825
aaaagaagaa aaaaaggcag                                                   20


<210>  6826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6826
uuuugaaguu ugguuguaaa                                                   20


<210>  6827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6827
ucuuuuugaa guuugguugu                                                   20


<210>  6828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6828
auuuuuuuuc auuuuaaauu                                                   20


<210>  6829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6829
uuuuaaauuu uccauaagua                                                   20


<210>  6830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6830
auaaguaaug uaaucaguca                                                   20


<210>  6831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6831
augguuuccu auuuccuaug                                                   20


<210>  6832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6832
uauuuccuau gcugaaaaac                                                   20


<210>  6833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6833
uaugcugaaa aacagcagag                                                   20


<210>  6834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6834
gcauaggaaa uaggaaacca                                                   20


<210>  6835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6835
caguagccug uaagacccuu                                                   20


<210>  6836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6836
uaacuugacc ucugguaucu                                                   20


<210>  6837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6837
ggucuuugcu agaugucacc                                                   20


<210>  6838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6838
cuggggugac aucuagcaaa                                                   20


<210>  6839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6839
ugaucacccu acugaaaauc                                                   20


<210>  6840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6840
caucacucag ccauuuacag                                                   20


<210>  6841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6841
acacuguaga gguguuuuua                                                   20


<210>  6842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6842
cugugccaga ccuccccuca                                                   20


<210>  6843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6843
ugaggggagg ucuggcacag                                                   20


<210>  6844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6844
uucaaccauc cucugcucau                                                   20


<210>  6845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6845
accauccucu gcucaugcuu                                                   20


<210>  6846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6846
uccuuugcuu gaacaccagg                                                   20


<210>  6847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6847
agcaaaggau gaaggagaga                                                   20


<210>  6848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6848
caagacaggc gaugcgucuu                                                   20


<210>  6849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6849
ugcucucacu cacccuuccu                                                   20


<210>  6850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6850
uuccauucca gcuuggagug                                                   20


<210>  6851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6851
uuguuaaacc aucagcugcc                                                   20


<210>  6852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6852
ccuuauuuca aacugacaug                                                   20


<210>  6853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6853
aacugacaug agacacaaaa                                                   20


<210>  6854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6854
uuugugucuc augucaguuu                                                   20


<210>  6855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6855
acucuucuug aaaauuuccc                                                   20


<210>  6856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6856
ugaaaauuuc ccccacuacc                                                   20


<210>  6857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6857
gcaacucaug uaacauuaca                                                   20


<210>  6858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6858
auguaauguu acaugaguug                                                   20


<210>  6859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6859
ucaaagcugg cgguuugagg                                                   20


<210>  6860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6860
cagaaggauu uggcacagcu                                                   20


<210>  6861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6861
gugaaaacuu ccucaaagcu                                                   20


<210>  6862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6862
ggccauguca ucaucagcug                                                   20


<210>  6863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6863
aagcuccaaa cucaugccaa                                                   20


<210>  6864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6864
cuagguucua agcuccaaac                                                   20


<210>  6865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6865
uccacacauu uucagcagaa                                                   20


<210>  6866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6866
cgauaaaaua aucacauuuu                                                   20


<210>  6867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6867
cuauucuauu uacuuuggaa                                                   20


<210>  6868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6868
auuuacuuug gaagaaaaau                                                   20


<210>  6869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6869
aaaguaaaua gaauagggaa                                                   20


<210>  6870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6870
uccaaaguaa auagaauagg                                                   20


<210>  6871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6871
guucuagaga aagcuggugu                                                   20


<210>  6872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6872
agagaaagcu gguguguucu                                                   20


<210>  6873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6873
cuagaacgga aagauuuuuc                                                   20


<210>  6874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6874
uuucaugaaa cuggcaaaca                                                   20


<210>  6875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6875
uuagaaagau auacaccaaa                                                   20


<210>  6876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6876
aaagaauaua ucuagcauau                                                   20


<210>  6877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6877
caacaauaac ucuaacuccu                                                   20


<210>  6878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6878
aacuauuuug uguaccuaaa                                                   20


<210>  6879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6879
uuugauauuu uuuguuuugc                                                   20


<210>  6880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6880
caccuacuca gaagucuuaa                                                   20


<210>  6881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6881
gaguaggugu gaauuccuuu                                                   20


<210>  6882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6882
guuuuucuau uaaauauagg                                                   20


<210>  6883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6883
auuaaauaua gguguuuaaa                                                   20


<210>  6884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6884
aguguaauuu uaaacaccua                                                   20


<210>  6885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6885
ugccagaucu gucauuuguu                                                   20


<210>  6886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6886
uuaggcuuaa augggcuaaa                                                   20


<210>  6887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6887
uaggcaauuu ucuguuuugg                                                   20


<210>  6888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6888
guuuuggaaa uacugcauau                                                   20


<210>  6889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6889
aaaacagaaa auugccuagg                                                   20


<210>  6890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6890
uuuuagacca acaugucuuu                                                   20


<210>  6891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6891
caggaaugau uaaggcaaau                                                   20


<210>  6892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6892
ugugaaaaga cauguugguc                                                   20


<210>  6893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6893
uauuugccuu aaucauuccu                                                   20


<210>  6894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6894
aggugugaug acauuucaua                                                   20


<210>  6895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6895
uuagugccug gauauaacuu                                                   20


<210>  6896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6896
uaagacaaag caaaaucauu                                                   20


<210>  6897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6897
gggcuuuauu uucuucagac                                                   20


<210>  6898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6898
ucagaccaag agugguauga                                                   20


<210>  6899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6899
gaccaagagu gguaugaggg                                                   20


<210>  6900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6900
uuuugacagg ucuauuugga                                                   20


<210>  6901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6901
auuucauuuu gacaggucua                                                   20


<210>  6902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6902
uuccauuuca uuuugacagg                                                   20


<210>  6903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6903
uacuucuaag uuguagagca                                                   20


<210>  6904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6904
aaguuguaga gcacucugaa                                                   20


<210>  6905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6905
gagugcucua caacuuagaa                                                   20


<210>  6906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6906
cggggcaaaa gaucgaaaca                                                   20


<210>  6907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6907
aucuuuugcc ccgggaaugu                                                   20


<210>  6908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6908
aaaauugaac uggcacuugg                                                   20


<210>  6909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6909
auuuuagaaa gucuguuucg                                                   20


<210>  6910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6910
caguccucaa aaucuccauc                                                   20


<210>  6911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6911
gacagcaaug uuuucuaagu                                                   20


<210>  6912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6912
aaguuuaaga gaaugagaaa                                                   20


<210>  6913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6913
cuuaaacuua gaaaacauug                                                   20


<210>  6914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6914
cauucucuua aacuuagaaa                                                   20


<210>  6915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6915
uucccucuuu aauauaagcc                                                   20


<210>  6916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6916
cucuuuaaua uaagccacac                                                   20


<210>  6917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6917
aaaaauuaac uucauaaaac                                                   20


<210>  6918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6918
uaaaaccaca ucacuccgua                                                   20


<210>  6919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6919
agccuaccac uuuagcaauc                                                   20


<210>  6920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6920
auuuuauaau uuagugguag                                                   20


<210>  6921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6921
aacaacuuuu ucuacaucaa                                                   20


<210>  6922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6922
acaucaauuu auucugagaa                                                   20


<210>  6923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6923
gagaacauaa uuaaacaaua                                                   20


<210>  6924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6924
cagaauaaau ugauguagaa                                                   20


<210>  6925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6925
uuaagggauu uauccauaua                                                   20


<210>  6926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6926
aacaauuaac aaaaaugaac                                                   20


<210>  6927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6927
uuuuuguuaa uuguuagaau                                                   20


<210>  6928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6928
caguugauau uuaaaguuca                                                   20


<210>  6929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6929
aagaggcauc auggguaaug                                                   20


<210>  6930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6930
uuacccauga ugccucuuug                                                   20


<210>  6931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6931
guugagacgu uuuucauuac                                                   20


<210>  6932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6932
agcuauccuc cuaccucagc                                                   20


<210>  6933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6933
uccuaaagaa ucaaguugau                                                   20


<210>  6934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6934
uaaagaauca aguugaucaa                                                   20


<210>  6935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6935
uuaggaagaa agguaugagu                                                   20


<210>  6936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6936
ugaauggcug gaucaguggg                                                   20


<210>  6937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6937
ggaagcccuu gaucaacuug                                                   20


<210>  6938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6938
gcucuugaua cccacugauc                                                   20


<210>  6939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6939
guacucguag aguuauccug                                                   20


<210>  6940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6940
ggauaacucu acgaguacgg                                                   20


<210>  6941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6941
aauacaaauu uuuucauaua                                                   20


<210>  6942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6942
uauaagccau aguuuaauuc                                                   20


<210>  6943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6943
acaaagucca uuaguaugga                                                   20


<210>  6944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6944
cucugccaag ccucacaaau                                                   20


<210>  6945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6945
agauuggcga gcugauaaag                                                   20


<210>  6946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6946
ccugauggaa aaaagcaaaa                                                   20


<210>  6947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6947
aucaggagaa aucccucccu                                                   20


<210>  6948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6948
auuuugcuuu uuuccaucag                                                   20


<210>  6949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6949
aauuuacaaa agaauguucu                                                   20


<210>  6950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6950
uuuguaaauu ugaauuucua                                                   20


<210>  6951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6951
ccuuuccuaa ucaaacuuac                                                   20


<210>  6952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6952
cuacugggga gcagucauua                                                   20


<210>  6953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6953
gauaugacua aagcacuauu                                                   20


<210>  6954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6954
gguuauaagg aauaagaaau                                                   20


<210>  6955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6955
uuauaaccag aaaauagugc                                                   20


<210>  6956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6956
uauuccuuau aaccagaaaa                                                   20


<210>  6957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6957
cacuuguaaa uacguugugu                                                   20


<210>  6958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6958
ggauaaaugu gagacaguua                                                   20


<210>  6959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6959
aguuuaauaa uuuuuaacug                                                   20


<210>  6960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6960
gagugggguu ucuuuuuaaa                                                   20


<210>  6961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6961
uuuuaaaauu cuuguuauau                                                   20


<210>  6962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6962
uguuauauau gaaauauaau                                                   20


<210>  6963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6963
uauauaacaa gaauuuuaaa                                                   20


<210>  6964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6964
aguuuagugc aaguugagua                                                   20


<210>  6965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6965
uugaucucuc uaguaagguu                                                   20


<210>  6966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6966
agacuauaaa agccuaaaaa                                                   20


<210>  6967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6967
gcuuuuuagg cuuuuauagu                                                   20


<210>  6968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6968
aggcacuguu uuaggugucg                                                   20


<210>  6969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6969
cugcugcguc cucgacaccu                                                   20


<210>  6970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6970
guuuuguuca cugcugcguc                                                   20


<210>  6971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6971
ucuguuuugu ucacugcugc                                                   20


<210>  6972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6972
gguuaaaacu aaaaagugga                                                   20


<210>  6973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6973
gacaacuguu ucaaggagcu                                                   20


<210>  6974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6974
aggagcuuug cugauuuugg                                                   20


<210>  6975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6975
aaaaucagca aagcuccuug                                                   20


<210>  6976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6976
ccuuccaaaa ucagcaaagc                                                   20


<210>  6977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6977
guuacugccc cauucuccuu                                                   20


<210>  6978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6978
uguuuuuaaa uggaaauuga                                                   20


<210>  6979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6979
auuuaaaaac aagaacuuaa                                                   20


<210>  6980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6980
uaugccaugg agcagguacu                                                   20


<210>  6981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6981
ucauaugcca uggagcaggu                                                   20


<210>  6982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6982
accagcucca gcagcagcag                                                   20


<210>  6983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6983
ucaaccagcu ccagcagcag                                                   20


<210>  6984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6984
gcagauucuu caaccagcuc                                                   20


<210>  6985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6985
ggcaguggga ccccaucugg                                                   20


<210>  6986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6986
cuguaaggau uuguucauca                                                   20


<210>  6987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6987
ucagaaaagc ccaguuggug                                                   20


<210>  6988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6988
gaugaacaaa uccuuacagu                                                   20


<210>  6989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6989
cugucagcug caaaaagugg                                                   20


<210>  6990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6990
uaauuauuga gaggaaaagg                                                   20


<210>  6991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6991
ucucaauaau uaagaaacca                                                   20


<210>  6992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6992
uuuuccucuc aauaauuaag                                                   20


<210>  6993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6993
ucaaaacugc uuauuuaaac                                                   20


<210>  6994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6994
accggacacu cccuaugguu                                                   20


<210>  6995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6995
uuacugugag ccuguaaaau                                                   20


<210>  6996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6996
cucacaacgu guuuaauuuu                                                   20


<210>  6997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6997
uuuauuuauu cauuuaaaca                                                   20


<210>  6998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6998
uuucaggucu uuauucuaca                                                   20


<210>  6999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  6999
ggucuuuauu cuacauuugu                                                   20


<210>  7000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7000
acauuuguuu accaaacuac                                                   20


<210>  7001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7001
uguugucuua uuauuuucau                                                   20


<210>  7002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7002
uaauguaaac cuaccucgac                                                   20


<210>  7003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7003
cugucgaggu agguuuacau                                                   20


<210>  7004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7004
uggacaucuu uuaacccuua                                                   20


<210>  7005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7005
accucauggu gccucauuuc                                                   20


<210>  7006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7006
uggaacagag uaaaaauccu                                                   20


<210>  7007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7007
acgaacuauu cuaccucaug                                                   20


<210>  7008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7008
uuuuuuaagg auuuuuacuc                                                   20


<210>  7009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7009
uuuuuuuaag auguauguug                                                   20


<210>  7010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7010
ggcagagcgc uaugugauca                                                   20


<210>  7011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7011
aauacauuuu aauacuuuuu                                                   20


<210>  7012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7012
uucuugauaa auuaauggac                                                   20


<210>  7013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7013
gugaacacau gaaaucugac                                                   20


<210>  7014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7014
cagaauugua uaucauauuu                                                   20


<210>  7015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7015
uguguucaca gaauuguaua                                                   20


<210>  7016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7016
gaacugccug agaauuagaa                                                   20


<210>  7017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7017
gaacuuuguc agauuucaug                                                   20


<210>  7018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7018
caggcaguuc agaacuuugu                                                   20


<210>  7019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7019
aauucucagg caguucagaa                                                   20


<210>  7020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7020
auuaaauaua cuuaacagag                                                   20


<210>  7021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7021
aaauuauucc agucuauggg                                                   20


<210>  7022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7022
agucuauggg caagaacuag                                                   20


<210>  7023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7023
ugcccauaga cuggaauaau                                                   20


<210>  7024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7024
aguucuugcc cauagacugg                                                   20


<210>  7025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7025
aguucuaguu cuugcccaua                                                   20


<210>  7026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7026
gacgaaaaau uuuuagaaaa                                                   20


<210>  7027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7027
ucugaauuuc aaguucuagu                                                   20


<210>  7028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7028
aaaaauuuuu cgucugaauu                                                   20


<210>  7029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7029
guauccauaa uuguuccaac                                                   20


<210>  7030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7030
uuccaaacua gugaaaugag                                                   20


<210>  7031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7031
aaacuaguga aaugagauaa                                                   20


<210>  7032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7032
cuaguuugga aagaacuuuu                                                   20


<210>  7033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7033
gguucaaauu cgacuuugaa                                                   20


<210>  7034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7034
aauucgacuu ugaagcuaua                                                   20


<210>  7035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7035
acuuugaagc uauauauucu                                                   20


<210>  7036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7036
uauuuggugg acuacagaga                                                   20


<210>  7037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7037
gaauaaaaag cacuuaguaa                                                   20


<210>  7038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7038
gaaucauuuc auauuuggug                                                   20


<210>  7039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7039
cuuuacuaag ugcuuuuuau                                                   20


<210>  7040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7040
acucaugaua agaacacuaa                                                   20


<210>  7041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7041
gccauuuaaa aaagaagucu                                                   20


<210>  7042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7042
uuuuuaaaug gcagaaguaa                                                   20


<210>  7043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7043
cagacuucuu uuuuaaaugg                                                   20


<210>  7044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7044
uucauauuaa caaaguacag                                                   20


<210>  7045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7045
uauuaacaaa guacagugac                                                   20


<210>  7046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7046
auucuucuuu uuuaaaauga                                                   20


<210>  7047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7047
uccauucuuc uuuuuuaaaa                                                   20


<210>  7048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7048
ccuuuuuaaa ggaaggcuuu                                                   20


<210>  7049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7049
uuuaaaaagg ggaaucaaag                                                   20


<210>  7050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7050
uuugcuuguu aaagccuucc                                                   20


<210>  7051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7051
caacgggaua uuccuuugcu                                                   20


<210>  7052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7052
uauucacaac gggauauucc                                                   20


<210>  7053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7053
agaguagaga aagacucuau                                                   20


<210>  7054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7054
cuacucuaga auggcuauuc                                                   20


<210>  7055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7055
cagagcacuc gccaguuuuc                                                   20


<210>  7056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7056
cacaaacauu uggggauaaa                                                   20


<210>  7057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7057
cacuaaaaau uauuuugaaa                                                   20


<210>  7058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7058
aaauaauuuu uagugagaac                                                   20


<210>  7059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7059
aauaauaaaa guauuuuuca                                                   20


<210>  7060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7060
acuucauucu gcuuacccua                                                   20


<210>  7061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7061
uucugcuuac ccuauuaaug                                                   20


<210>  7062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7062
gcuuacccua uuaaugcccu                                                   20


<210>  7063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7063
aggagaaaag cuauaucuaa                                                   20


<210>  7064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7064
aaacaguaag uuauucauac                                                   20


<210>  7065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7065
uacuacauag aauaaaagua                                                   20


<210>  7066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7066
auguaguaug aauaacuuac                                                   20


<210>  7067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7067
uuuuacuuuu auucuaugua                                                   20


<210>  7068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7068
uguuuuaguu uuuauuugau                                                   20


<210>  7069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7069
cugucccuau ccuucuaccu                                                   20


<210>  7070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7070
guguguaggu caucaccagg                                                   20


<210>  7071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7071
aaagaggcac agauucaggg                                                   20


<210>  7072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7072
gggauguaug auggggaaca                                                   20


<210>  7073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7073
cuucugauca cuuaccuaua                                                   20


<210>  7074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7074
gaucacuuac cuauaaggag                                                   20


<210>  7075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7075
gucuccuuau agguaaguga                                                   20


<210>  7076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7076
gcacuuggug gccccacucu                                                   20


<210>  7077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7077
cuaucagggu uucucaaccu                                                   20


<210>  7078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7078
caaccuggac ucuagugaca                                                   20


<210>  7079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7079
ggacaggaua auuugcuguu                                                   20


<210>  7080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7080
aauacuugaa uuuuuuuuau                                                   20


<210>  7081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7081
aauaccccuu augagguccc                                                   20


<210>  7082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7082
aguauucgaa uaccccuuau                                                   20


<210>  7083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7083
auccaaauau gucauuauaa                                                   20


<210>  7084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7084
cuaauuguga cuucuaucca                                                   20


<210>  7085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7085
aauaaguuaa gcuuucuggu                                                   20


<210>  7086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7086
aaaagcauaa aaugcuacug                                                   20


<210>  7087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7087
guugauaugc uuaaguuuua                                                   20


<210>  7088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7088
uauucaguug auaugcuuaa                                                   20


<210>  7089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7089
agcaugacgg uuaaagccuu                                                   20


<210>  7090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7090
aauggacaaa gacaaccaau                                                   20


<210>  7091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7091
ccuaguuaua ccauaaaugu                                                   20


<210>  7092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7092
uguuucaccu aguuauacca                                                   20


<210>  7093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7093
ucauguuuca ccuaguuaua                                                   20


<210>  7094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7094
uaauuuuaua uuuuuagaua                                                   20


<210>  7095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7095
uucauaauuu uauauuuuua                                                   20


<210>  7096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7096
aaucuugugu agcaaucagc                                                   20


<210>  7097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7097
uugcugauug cuacacaaga                                                   20


<210>  7098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7098
uauguaaaga uacugaaucc                                                   20


<210>  7099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7099
guaucuuuac auaagaaauu                                                   20


<210>  7100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7100
ggauucagua ucuuuacaua                                                   20


<210>  7101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7101
auauacucuu ucaggauuca                                                   20


<210>  7102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7102
ggacaaaaua ucaaaauaaa                                                   20


<210>  7103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7103
uuauuuugau auuuuguccu                                                   20


<210>  7104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7104
uuccuuagau accuaccuuc                                                   20


<210>  7105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7105
uuagauaccu accuucuuua                                                   20


<210>  7106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7106
uuaaucuagg auuuagauua                                                   20


<210>  7107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7107
gcuaaucaua aacuauaguu                                                   20


<210>  7108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7108
uuagcaauuu cuucaucagg                                                   20


<210>  7109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7109
ucaucaggug auuccauggc                                                   20


<210>  7110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7110
ucaggugauu ccauggcuau                                                   20


<210>  7111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7111
auggcuauuu uccaaaugaa                                                   20


<210>  7112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7112
aaaugaaauc cauuccuauc                                                   20


<210>  7113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7113
uuuggaaaau agccauggaa                                                   20


<210>  7114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7114
uaucaauucc agcuuuucua                                                   20


<210>  7115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7115
agcuuuucua cauacuguuc                                                   20


<210>  7116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7116
acauacuguu caaaagaaaa                                                   20


<210>  7117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7117
aaagaaaaaa aauuaaauua                                                   20


<210>  7118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7118
uuugaacagu auguagaaaa                                                   20


<210>  7119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7119
guucaauaug aauuaaggcu                                                   20


<210>  7120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7120
auaugaauua aggcugcaaa                                                   20


<210>  7121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7121
uauugaacug aagaggugug                                                   20


<210>  7122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7122
uauagcugag guuuugcagc                                                   20


<210>  7123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7123
auaucaguau aauauuauuu                                                   20


<210>  7124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7124
gugguugguu gcuuuuuaaa                                                   20


<210>  7125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7125
acgggaacca ggauagguac                                                   20


<210>  7126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7126
caaaucuaga uaguuuggau                                                   20


<210>  7127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7127
aucgaugauc acaaagauuc                                                   20


<210>  7128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7128
cauuuucaaa aaaaguuuua                                                   20


<210>  7129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7129
aaaaaaguuu uaaauaaguu                                                   20


<210>  7130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7130
auaauuacag guuuuaacuu                                                   20


<210>  7131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7131
uguacucuac guaacacaga                                                   20


<210>  7132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7132
cauccucaac aauacuuguu                                                   20


<210>  7133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7133
ucacauccuc aacaauacuu                                                   20


<210>  7134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7134
aauuucuuca cauccucaac                                                   20


<210>  7135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7135
uaaucccacc agcaauauau                                                   20


<210>  7136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7136
ugaaagguua auuauauguc                                                   20


<210>  7137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7137
ggaacugucu guuuugcaaa                                                   20


<210>  7138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7138
gacauauaau uaaccuuuca                                                   20


<210>  7139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7139
agauauacau ccaagagaaa                                                   20


<210>  7140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7140
cuuggaugua uaucuagaag                                                   20


<210>  7141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7141
uguagaaagg aauuugagua                                                   20


<210>  7142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7142
acaugaaugg uaucuuauaa                                                   20


<210>  7143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7143
uuucuacaug aaugguaucu                                                   20


<210>  7144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7144
guacuuuuaa guaagaagug                                                   20


<210>  7145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7145
uaccauucau agugauuuca                                                   20


<210>  7146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7146
uagugauuuc auaugacucc                                                   20


<210>  7147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7147
uaugacucca auuuaagaau                                                   20


<210>  7148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7148
uaaauuggag ucauaugaaa                                                   20


<210>  7149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7149
ccuugaagag cugcugcuga                                                   20


<210>  7150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7150
aggagaaaau ucuuaaauug                                                   20


<210>  7151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7151
gcagcagcuc uucaaggaga                                                   20


<210>  7152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7152
aaacacaucu guggaauaag                                                   20


<210>  7153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7153
acagaugugu uuugaauggu                                                   20


<210>  7154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7154
ucuuauucca cagauguguu                                                   20


<210>  7155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7155
aagcauuuua gcuuugagug                                                   20


<210>  7156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7156
gaaauuaaau gaagcaguua                                                   20


<210>  7157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7157
gaauuccaag cauuuuagcu                                                   20


<210>  7158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7158
uuuaauuuca gaauuccaag                                                   20


<210>  7159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7159
gccuuacuuu auccacaaua                                                   20


<210>  7160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7160
uaccucucua ucuaauucac                                                   20


<210>  7161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7161
caaacauccu ggccaguuac                                                   20


<210>  7162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7162
agcccagaua cagaguagcu                                                   20


<210>  7163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7163
ugcaagaaaa acgcuagaaa                                                   20


<210>  7164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7164
ugcaagaagc uacucuguau                                                   20


<210>  7165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7165
agcguuuuuc uugcaagaag                                                   20


<210>  7166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7166
uuuugcagua uuuagaggca                                                   20


<210>  7167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7167
uuccuaaaag caacauuaaa                                                   20


<210>  7168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7168
uaaaagcaac auuaaaacaa                                                   20


<210>  7169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7169
ugauuuacaa cauuaauuug                                                   20


<210>  7170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7170
cguuaccaau uucacuauuu                                                   20


<210>  7171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7171
cuauuucaaa auucuucuuc                                                   20


<210>  7172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7172
aaauucuucu ucaagucuug                                                   20


<210>  7173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7173
ucuucaaguc uugaauaaug                                                   20


<210>  7174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7174
ucaagucuug aauaaugcuc                                                   20


<210>  7175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7175
agucuugaau aaugcucuug                                                   20


<210>  7176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7176
agacuugaag aagaauuuug                                                   20


<210>  7177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7177
ccaagagcau uauucaagac                                                   20


<210>  7178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7178
uuuuguuauu uucgccaaga                                                   20


<210>  7179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7179
cauuaccacu uuucuuuuug                                                   20


<210>  7180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7180
uaaaacaaac cuaucaaaag                                                   20


<210>  7181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7181
uggagcugac gcaaagcugg                                                   20


<210>  7182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7182
uuuuaacucu agucaucuca                                                   20


<210>  7183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7183
aaauuuaauu aauguaacuu                                                   20


<210>  7184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7184
uuuauuagcu auaaaaaauu                                                   20


<210>  7185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7185
agucaaucag guuuacuguu                                                   20


<210>  7186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7186
gucuucaacu ucuuauucug                                                   20


<210>  7187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7187
acuucuuauu cugcaugcaa                                                   20


<210>  7188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7188
uauucugcau gcaauuuccu                                                   20


<210>  7189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7189
gcaugcaauu uccuaaagcu                                                   20


<210>  7190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7190
uaaagcuaag aacugcaaac                                                   20


<210>  7191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7191
uagcuuuagg aaauugcaug                                                   20


<210>  7192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7192
cauccacucc uguuugcagu                                                   20


<210>  7193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7193
uuguugucug uuuuuugcug                                                   20


<210>  7194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7194
gaggauagau uaaguagcac                                                   20


<210>  7195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7195
guguuaucca aguuaagcuu                                                   20


<210>  7196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7196
uacuccauuu uacuuaccau                                                   20


<210>  7197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7197
augauuauau gacuaggaua                                                   20


<210>  7198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7198
uuaauauuua gaccacuacc                                                   20


<210>  7199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7199
uaaucuguau uuccuaguua                                                   20


<210>  7200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7200
uaguuaaaac acuuucauaa                                                   20


<210>  7201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7201
uaagagguaa uucuauuuuu                                                   20


<210>  7202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7202
auuuuuauua uuacagacau                                                   20


<210>  7203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7203
aaacacuucc aaauauauua                                                   20


<210>  7204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7204
aaauauauua uuucugaaac                                                   20


<210>  7205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7205
gaaacuggua uaugacaauc                                                   20


<210>  7206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7206
gaaauaauau auuuggaagu                                                   20


<210>  7207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7207
cuuuauaaag aguauuacac                                                   20


<210>  7208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7208
aacuaugaaa uuucaaaauu                                                   20


<210>  7209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7209
uaguuugaaa gaugcuauuu                                                   20


<210>  7210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7210
aaauuuggua agaauuucag                                                   20


<210>  7211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7211
uaccaaauuu ugaaauuuca                                                   20


<210>  7212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7212
guuuaaacau gacuauuaaa                                                   20


<210>  7213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7213
ccuccacaag ggucuucauc                                                   20


<210>  7214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7214
cuacaaagac aacaaaagug                                                   20


<210>  7215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7215
auagugagau guuucucuac                                                   20


<210>  7216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7216
uugccucaua gggaucagcc                                                   20


<210>  7217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7217
uagauucuaa gacaaagauu                                                   20


<210>  7218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7218
aagacaaaga uuucauauau                                                   20


<210>  7219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7219
uauauuuuaa cauaucugaa                                                   20


<210>  7220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7220
gauauguuaa aauauaugaa                                                   20


<210>  7221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7221
uuugacauaa uugucuaaag                                                   20


<210>  7222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7222
gaagucagga gaagcuggca                                                   20


<210>  7223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7223
gaaaaugcuu uagugugaga                                                   20


<210>  7224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7224
ccugacuucg gaaaaugcuu                                                   20


<210>  7225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7225
caggguauga gucugucaug                                                   20


<210>  7226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7226
agagaaggug uuuaacuugu                                                   20


<210>  7227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7227
cuugaaauaa ggugcagcuu                                                   20


<210>  7228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7228
uaauugaguu auguacacua                                                   20


<210>  7229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7229
cuuuuguaaa acucaacuug                                                   20


<210>  7230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7230
ucaacaugcc ucaaaauuau                                                   20


<210>  7231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7231
aagaugccag ugauugcacc                                                   20


<210>  7232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7232
gugauucuaa gaugccagug                                                   20


<210>  7233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7233
ggcuacacua uaaaaguugc                                                   20


<210>  7234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7234
caaaaggauu acaaaauugg                                                   20


<210>  7235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7235
uauuuauguc ccaauuuugu                                                   20


<210>  7236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7236
gcaagaagca aauauauuaa                                                   20


<210>  7237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7237
ugcugaagag uucauauuua                                                   20


<210>  7238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7238
auauuaaaua aaaauauugu                                                   20


<210>  7239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7239
aaggauaauu uucaauauua                                                   20


<210>  7240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7240
aagaaaaagu cuauaaaacu                                                   20


<210>  7241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7241
uugaauuuua uuguauaaca                                                   20


<210>  7242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7242
uaaauuuuag uuuuauagac                                                   20


<210>  7243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7243
gauauagccu ucuuaaaguu                                                   20


<210>  7244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7244
uaaaguuuag caaacaggaa                                                   20


<210>  7245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7245
uguuugcuaa acuuuaagaa                                                   20


<210>  7246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7246
ucuuaucuau gacgugguga                                                   20


<210>  7247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7247
uauaacuugu caccacguca                                                   20


<210>  7248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7248
ccaauuacaa ugaagauauc                                                   20


<210>  7249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7249
uuguaauugg agaagaguaa                                                   20


<210>  7250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7250
uaaguaggac cugaugggau                                                   20


<210>  7251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with TTCN PAM

<400>  7251
ucuaauguug aguccaauuu                                                   20


<210>  7252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7252
augacauucu gaugauucag                                                   20


<210>  7253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7253
uuuaaacuag auucugaucc                                                   20


<210>  7254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7254
gcuuugcgcu ugaauuaacu                                                   20


<210>  7255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7255
aaauggaaug gggccagugu                                                   20


<210>  7256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7256
gugguaagaa uuaggaugga                                                   20


<210>  7257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7257
uacacauaaa aaguuguauc                                                   20


<210>  7258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7258
uaggauacaa cuuuuuaugu                                                   20


<210>  7259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7259
ccuaggauac aacuuuuuau                                                   20


<210>  7260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7260
uugucaacug ucacugacau                                                   20


<210>  7261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7261
ccuugucaac ugucacugac                                                   20


<210>  7262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7262
ucuggaagaa gaugcccaau                                                   20


<210>  7263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7263
ccaguaauuu uuauauuucu                                                   20


<210>  7264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7264
aguaauuuuu auauuucuca                                                   20


<210>  7265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7265
guccaaccca uuccugaauc                                                   20


<210>  7266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7266
uccuuucuuc cuaguuucau                                                   20


<210>  7267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7267
auauaguaag gaaagaaaaa                                                   20


<210>  7268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7268
cuuaaaggaa gcacucuccu                                                   20


<210>  7269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7269
ccucacaggu cucccugaag                                                   20


<210>  7270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7270
ucacaggucu cccugaagcc                                                   20


<210>  7271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7271
caggucuccc ugaagccauc                                                   20


<210>  7272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7272
cugaagccau cgugcccacu                                                   20


<210>  7273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7273
aauucauccu ccauguggca                                                   20


<210>  7274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7274
auguggcacc gaguggucuu                                                   20


<210>  7275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7275
aggucuuugu acauaccauu                                                   20


<210>  7276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7276
cucauuuaga cauucuucag                                                   20


<210>  7277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7277
cauuuagaca uucuucagaa                                                   20


<210>  7278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7278
uuuagacauu cuucagaacu                                                   20


<210>  7279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7279
gcucaaaagu uacuuccuca                                                   20


<210>  7280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7280
aaaguuacuu ccucaaggaa                                                   20


<210>  7281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7281
aggaagccuu uccugacauu                                                   20


<210>  7282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7282
guaaagauac ccaaaaaugu                                                   20


<210>  7283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7283
gaagaagaca ggaaaaugug                                                   20


<210>  7284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7284
aggaaguucc aaacuuuccc                                                   20


<210>  7285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7285
gccuggauuu cauuguccau                                                   20


<210>  7286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7286
gauggagaug aggaacuugu                                                   20


<210>  7287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7287
aucugagacu accucagccu                                                   20


<210>  7288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7288
ucuccaucug agacuaccuc                                                   20


<210>  7289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7289
aguucccaac aaguuccuca                                                   20


<210>  7290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7290
ugcuauauuu uaguaaacag                                                   20


<210>  7291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7291
aaggcagggg caaaaugcca                                                   20


<210>  7292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7292
ugaaugcuuu gcugcuuaga                                                   20


<210>  7293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7293
acuucauuuu aaaacugaau                                                   20


<210>  7294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7294
gaaaaugggu uuuucuuuuc                                                   20


<210>  7295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7295
ugugucagca ugacccggcu                                                   20


<210>  7296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7296
cagccggguc augcugacac                                                   20


<210>  7297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7297
augucucaca gccgggucau                                                   20


<210>  7298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7298
uuucacucca ugucucacag                                                   20


<210>  7299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7299
aaaaugaucu ccuuucacuc                                                   20


<210>  7300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7300
caaaguauug ggauuacagg                                                   20


<210>  7301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7301
accucccaaa guauugggau                                                   20


<210>  7302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7302
agugauccac ccaccucaac                                                   20


<210>  7303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7303
ugggcucaag ugauccaccc                                                   20


<210>  7304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7304
aacuccuggg cucaagugau                                                   20


<210>  7305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7305
ugggguuaaa aacgaaagcu                                                   20


<210>  7306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7306
cccugugagg ccacaaggug                                                   20


<210>  7307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7307
cugugaggcc acaagguggc                                                   20


<210>  7308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7308
cagggagagc uuucguuuuu                                                   20


<210>  7309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7309
uugacuugcu gcuuugugcu                                                   20


<210>  7310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7310
acugccuucu ugagaggacc                                                   20


<210>  7311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7311
cgccuauaau cccagcacuu                                                   20


<210>  7312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7312
uuaguuuccu aaaaugaaca                                                   20


<210>  7313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7313
ucuaaauugg guuuuaacag                                                   20


<210>  7314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7314
ggaaaaaaaa aaaaucaauu                                                   20


<210>  7315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7315
guggcaaaau gaaagcaggc                                                   20


<210>  7316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7316
gggccuuguu uaacucugug                                                   20


<210>  7317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7317
cugggccuug uuuaacucug                                                   20


<210>  7318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7318
accacauagu uugcugugua                                                   20


<210>  7319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7319
cugccaagua cuccuuuuca                                                   20


<210>  7320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7320
ccaucacucc cugccaagua                                                   20


<210>  7321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7321
ccccuucucc ccaucacucc                                                   20


<210>  7322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7322
uuuccagaaa ccaaggaagu                                                   20


<210>  7323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7323
guguguuugc agcugcucca                                                   20


<210>  7324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7324
agguuaugug gagauugucu                                                   20


<210>  7325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7325
acauaaccug gagcagcugc                                                   20


<210>  7326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7326
cggggccugg gaagcacaau                                                   20


<210>  7327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7327
auuaccgcaa cuccucaauu                                                   20


<210>  7328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7328
ucaauuagac augugauggc                                                   20


<210>  7329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7329
auuagacaug ugauggcgga                                                   20


<210>  7330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7330
cgcagccugg gaaacagggu                                                   20


<210>  7331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7331
cugagcauuu cggcgucaga                                                   20


<210>  7332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7332
gggagacgga uuugaguaau                                                   20


<210>  7333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7333
gacgccgaaa ugcucaggga                                                   20


<210>  7334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7334
ccacuuccga agccccuacc                                                   20


<210>  7335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7335
ccaaccagca cuccccacuu                                                   20


<210>  7336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7336
aaucucacca accagcacuc                                                   20


<210>  7337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7337
accaguucug ccaucccacc                                                   20


<210>  7338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7338
auggaucagc ugacaccacc                                                   20


<210>  7339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7339
uccugugacu uagaaugccu                                                   20


<210>  7340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7340
uaucucaucc ugugacuuag                                                   20


<210>  7341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7341
ccaagacaga acaggauacc                                                   20


<210>  7342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7342
aagacagaac aggauaccug                                                   20


<210>  7343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7343
auucaccagg accagccaac                                                   20


<210>  7344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7344
uguuaugguu uugcaaaggc                                                   20


<210>  7345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7345
aaagaagaaa aaccagacua                                                   20


<210>  7346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7346
ccaaagaaga aaaaccagac                                                   20


<210>  7347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7347
cuccaaagaa gaaaaaccag                                                   20


<210>  7348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7348
cuuggugucu cucuccaaag                                                   20


<210>  7349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7349
acucugcuaa gccagagaau                                                   20


<210>  7350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7350
gcuaagccag agaauggcug                                                   20


<210>  7351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7351
cggccacaau gcuauacuuc                                                   20


<210>  7352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7352
gaagccacac uggguucaau                                                   20


<210>  7353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7353
acuucuuguu aaagcuaugu                                                   20


<210>  7354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7354
aaguagagau gcaauagaga                                                   20


<210>  7355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7355
acuuagaggg caaaguaaga                                                   20


<210>  7356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7356
auugcaucuc uacuuagagg                                                   20


<210>  7357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7357
cuauugcauc ucuacuuaga                                                   20


<210>  7358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7358
cucucuauug caucucuacu                                                   20


<210>  7359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7359
gaagcacuuu acauauguaa                                                   20


<210>  7360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7360
ucaagaccug acuaagaugu                                                   20


<210>  7361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7361
uauucacucu ucaagaccug                                                   20


<210>  7362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7362
ggauaaggag gagggaaagg                                                   20


<210>  7363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7363
uuauccagag aacucuuauu                                                   20


<210>  7364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7364
uccuuaucca gagaacucuu                                                   20


<210>  7365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7365
ugcccagaau gccuuucccu                                                   20


<210>  7366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7366
uuccucaucu cagugggaaa                                                   20


<210>  7367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7367
ucucaguggg aaaacuuuca                                                   20


<210>  7368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7368
gugggaaaac uuucaauauu                                                   20


<210>  7369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7369
auaugggaac cccuuaguuu                                                   20


<210>  7370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7370
gacuuuuagc auccuuauaa                                                   20


<210>  7371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7371
guaccugggu guaaucuccg                                                   20


<210>  7372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7372
cgguaccugg guguaaucuc                                                   20


<210>  7373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7373
uaguaggcuc uggagggaaa                                                   20


<210>  7374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7374
ggagggaaag caugcaaagu                                                   20


<210>  7375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7375
agagccuacu augagcuuuc                                                   20


<210>  7376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7376
gaccuuaggu gggcacaggu                                                   20


<210>  7377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7377
cuucuuagaa cagcagcaca                                                   20


<210>  7378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7378
ccuuuggugc uguuuggagc                                                   20


<210>  7379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7379
uuuggugcug uuuggagccc                                                   20


<210>  7380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7380
aaacagcacc aaaggagagu                                                   20


<210>  7381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7381
uuggagucug gggaaauucg                                                   20


<210>  7382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7382
aaagagugcu ggggcuccaa                                                   20


<210>  7383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7383
uuguuuuuac uuuguuugca                                                   20


<210>  7384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7384
uggcuaaggu uccaagcuau                                                   20


<210>  7385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7385
cagcaauaca aagacaugua                                                   20


<210>  7386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7386
cauuugucaa aagaaagcac                                                   20


<210>  7387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7387
aaaucuuccc uucagccuag                                                   20


<210>  7388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7388
cacucuaaau cuucccuuca                                                   20


<210>  7389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7389
agcagcuccc acucuaaauc                                                   20


<210>  7390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7390
cauucuauuc aaagucucac                                                   20


<210>  7391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7391
cuaagauaaa ugcauaucua                                                   20


<210>  7392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7392
uuuggaaagg cuaaucagaa                                                   20


<210>  7393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7393
aagcgggaga ggggacuugg                                                   20


<210>  7394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7394
ugccucccuu guuaaaagug                                                   20


<210>  7395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7395
cuuguuaaaa gugaaagaau                                                   20


<210>  7396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7396
auucuuucac uuuuaacaag                                                   20


<210>  7397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7397
cuaauaaccc uuuugggcac                                                   20


<210>  7398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7398
ccuacuacuu aaugguuccu                                                   20


<210>  7399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7399
aauucuuuau cagguuuuaa                                                   20


<210>  7400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7400
uagucuugau uaaaauaaaa                                                   20


<210>  7401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7401
gcuagauuuu guuuauguau                                                   20


<210>  7402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7402
acuaaaaaua caaaaauuag                                                   20


<210>  7403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7403
ugccaccaug cccagcuaau                                                   20


<210>  7404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7404
caaguagcug ggauuacagg                                                   20


<210>  7405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7405
gccucccaag uagcugggau                                                   20


<210>  7406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7406
gccucagccu cccaaguagc                                                   20


<210>  7407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7407
auuaauuccu gcggaccuga                                                   20


<210>  7408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7408
acacacuuaa cguaucaaga                                                   20


<210>  7409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7409
cacaaauaga auuuaagaca                                                   20


<210>  7410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7410
caaauagaau uuaagacaua                                                   20


<210>  7411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7411
agggcuacuc agggagagag                                                   20


<210>  7412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7412
gggagagaga gcccagaaac                                                   20


<210>  7413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7413
cugaguagcc cuggagaccc                                                   20


<210>  7414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7414
cccugaguag cccuggagac                                                   20


<210>  7415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7415
cucccugagu agcccuggag                                                   20


<210>  7416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7416
cucucccuga guagcccugg                                                   20


<210>  7417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7417
ggucucuuuc ucucugugca                                                   20


<210>  7418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7418
uucucucugu gcaaacuggu                                                   20


<210>  7419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7419
cugugcaaac ugguuaaaug                                                   20


<210>  7420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7420
gugcaaacug guuaaaugaa                                                   20


<210>  7421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7421
uauuauuauu aaaccaauua                                                   20


<210>  7422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7422
cgucacauga auuaaauaaa                                                   20


<210>  7423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7423
ugcaugggaa agcuuuuauc                                                   20


<210>  7424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7424
uaaaaccaaa uagaucaaag                                                   20


<210>  7425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7425
gaauucuugg uauuauccuc                                                   20


<210>  7426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7426
caauaguaau aauaauaguc                                                   20


<210>  7427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7427
cuggugugcu guauucucuc                                                   20


<210>  7428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7428
caaagguuuu aaaugcuugc                                                   20


<210>  7429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7429
aagguuuuaa augcuugcau                                                   20


<210>  7430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7430
auuuuuguuu gguuuggucu                                                   20


<210>  7431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7431
ugcaaaucuc uauagcaaac                                                   20


<210>  7432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7432
auagcaaaca uucuugacaa                                                   20


<210>  7433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7433
guugucaaga auguuugcua                                                   20


<210>  7434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7434
ccuagagacc accaaguuuu                                                   20


<210>  7435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7435
uagagaccac caaguuuuag                                                   20


<210>  7436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7436
aggagagaag aaaugaauuu                                                   20


<210>  7437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7437
gccucccaug aagauuuaug                                                   20


<210>  7438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7438
caugaagauu uauggggauc                                                   20


<210>  7439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7439
uacagaggaa augaggcagg                                                   20


<210>  7440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7440
guaagagaug ugauccccau                                                   20


<210>  7441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7441
uuuccucugu aagagaugug                                                   20


<210>  7442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7442
agacccuauu uuccugccuc                                                   20


<210>  7443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7443
acaauguggg accggggccc                                                   20


<210>  7444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7444
accgguaaca auagugcuga                                                   20


<210>  7445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7445
gagggcugaa gacacagaca                                                   20


<210>  7446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7446
gaggcugugc accaucuaaa                                                   20


<210>  7447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7447
gccuaguguc ugugucuuca                                                   20


<210>  7448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7448
caacaccagc agagagcugg                                                   20


<210>  7449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7449
acaccagcag agagcuggcc                                                   20


<210>  7450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7450
gcugguguug agagcuguuu                                                   20


<210>  7451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7451
cugcuggugu ugagagcugu                                                   20


<210>  7452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7452
aaugucugga gcuguagcag                                                   20


<210>  7453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7453
agacauucga ggcagaacga                                                   20


<210>  7454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7454
cgcugacacg auggcugcua                                                   20


<210>  7455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7455
ugaagcugaa auuuccauaa                                                   20


<210>  7456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7456
ggggcagagg ggagcuuucu                                                   20


<210>  7457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7457
gccccagaga aaggcagcgu                                                   20


<210>  7458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7458
ccucugcccc agagaaaggc                                                   20


<210>  7459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7459
uagaaagcuc cccucugccc                                                   20


<210>  7460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7460
ucuuagacuc cuagaaagcu                                                   20


<210>  7461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7461
caccaccagc cccucuucuu                                                   20


<210>  7462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7462
ugcucacacc accagccccu                                                   20


<210>  7463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7463
aucuucagag cccaaucagg                                                   20


<210>  7464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7464
gaagauggag ggucacaggu                                                   20


<210>  7465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7465
acugaccccc ugauugggcu                                                   20


<210>  7466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7466
gagagcacgg cugagaauua                                                   20


<210>  7467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7467
gagauccccc auucuccacu                                                   20


<210>  7468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7468
cagagauccc ccauucucca                                                   20


<210>  7469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7469
gccgugcucu cagagauccc                                                   20


<210>  7470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7470
aauucucagc cgugcucuca                                                   20


<210>  7471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7471
ucaggaaagg gauggcuugg                                                   20


<210>  7472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7472
ggaaagggau ggcuuggcag                                                   20


<210>  7473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7473
uccuucccac ugcugccaag                                                   20


<210>  7474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7474
ccugaaguuu uguguuuuua                                                   20


<210>  7475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7475
auaccaucag aauucucacc                                                   20


<210>  7476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7476
gccuccugag uagcugggau                                                   20


<210>  7477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7477
ugaguagcug ggauuauagg                                                   20


<210>  7478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7478
ggaggcugag gcaaaagaau                                                   20


<210>  7479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7479
ugcuggccaa guuuucucca                                                   20


<210>  7480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7480
agcucuggga agccacagug                                                   20


<210>  7481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7481
gggaagccac agugguuaag                                                   20


<210>  7482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7482
aaauguucca aagaacaauc                                                   20


<210>  7483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7483
aucacuguag aagcuuccag                                                   20


<210>  7484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7484
caaucacugu agaagcuucc                                                   20


<210>  7485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7485
ucucaaucac uguagaagcu                                                   20


<210>  7486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7486
gcaggcuaau ggcagaguca                                                   20


<210>  7487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7487
gccauuagcc ugcagaguga                                                   20


<210>  7488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7488
ugacucugcc auuagccugc                                                   20


<210>  7489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7489
guuucccgau cuguaaaaag                                                   20


<210>  7490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7490
cagucucagu uucccgaucu                                                   20


<210>  7491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7491
cacccuccca gucucaguuu                                                   20


<210>  7492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7492
gggauucagg cagacccaug                                                   20


<210>  7493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7493
uggaguccag gcugucacca                                                   20


<210>  7494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7494
aagagugacc ucagggauuc                                                   20


<210>  7495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7495
ccauccacag acccucccag                                                   20


<210>  7496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7496
auccacagac ccucccagcu                                                   20


<210>  7497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7497
cagcucuuag cucuuugucu                                                   20


<210>  7498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7498
uagcucuuug ucuugguucc                                                   20


<210>  7499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7499
cagaacagca gccgcagaau                                                   20


<210>  7500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7500
aggcuuugcc uuccuuggaa                                                   20


<210>  7501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7501
aaaaaaggaa augacagucu                                                   20


<210>  7502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7502
gaggacgcag cuacuucucu                                                   20


<210>  7503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7503
gaguuuaugc ucuaaaaaag                                                   20


<210>  7504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7504
ccaugaauag gcugucuccc                                                   20


<210>  7505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7505
augaauaggc ugucucccag                                                   20


<210>  7506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7506
caggcacaga auuccaggaa                                                   20


<210>  7507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7507
ucccuugaaa ccaaccuuga                                                   20


<210>  7508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7508
agccacccug caagggacac                                                   20


<210>  7509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7509
aagagccuga aaaaucaucu                                                   20


<210>  7510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7510
uggagcuggc uccagccacc                                                   20


<210>  7511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7511
ggacccaaca ggaaucuugg                                                   20


<210>  7512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7512
guucugugau cuugguuauu                                                   20


<210>  7513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7513
gagccucagu uuccucaauc                                                   20


<210>  7514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7514
gagaaauuca aauaaccaag                                                   20


<210>  7515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7515
guuuccucaa uccuuaggug                                                   20


<210>  7516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7516
auccuuaggu ggaaauaaaa                                                   20


<210>  7517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7517
uaccuuaagg ucugcugauu                                                   20


<210>  7518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7518
caugauuagg uuagacccac                                                   20


<210>  7519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7519
ugugcugugc aaucuuggcc                                                   20


<210>  7520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7520
gccugucacu caugugcugu                                                   20


<210>  7521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7521
uucuuuacau acuacuuuug                                                   20


<210>  7522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7522
aaaaaguuuu auuggaacac                                                   20


<210>  7523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7523
cuuuccuuuu cugggccuau                                                   20


<210>  7524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7524
aacagcuucu aguagcaacc                                                   20


<210>  7525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7525
agcggguagg gaagggagcu                                                   20


<210>  7526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7526
gaagaaaacu ggccaucagc                                                   20


<210>  7527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7527
gcugggcgac ucagaagaaa                                                   20


<210>  7528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7528
gaauuucccu ggcucggcug                                                   20


<210>  7529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7529
ggacccagcc ggaugcagua                                                   20


<210>  7530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7530
ggaggucccc auaaacuagg                                                   20


<210>  7531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7531
ugagugcagg gaccaggugu                                                   20


<210>  7532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7532
ccuaguuuau ggggaccucc                                                   20


<210>  7533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7533
auuugugaau cuccccuagu                                                   20


<210>  7534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7534
ggcccuggaa cuggacaagu                                                   20


<210>  7535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7535
ggcccugcuu caaccugaau                                                   20


<210>  7536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7536
cgauggcccu gccccaggug                                                   20


<210>  7537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7537
cuccuuuacg ggcacucagc                                                   20


<210>  7538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7538
uuuacgggca cucagccccu                                                   20


<210>  7539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7539
gccccuucug ucgucgaccu                                                   20


<210>  7540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7540
gcuuccuaag cagcuaggau                                                   20


<210>  7541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7541
ugccucagcu uccuaagcag                                                   20


<210>  7542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7542
ggaggcagag ggugcaauga                                                   20


<210>  7543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7543
ugaguucaag ugauucuccu                                                   20


<210>  7544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7544
gccuccugag uucaagugau                                                   20


<210>  7545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7545
uugcacccuc ugccuccuga                                                   20


<210>  7546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7546
gcucauugca cccucugccu                                                   20


<210>  7547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7547
accccaaccg ucccccagga                                                   20


<210>  7548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7548
uuccaugugg aucccccaca                                                   20


<210>  7549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7549
cuccuuccau guggaucccc                                                   20


<210>  7550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7550
cauggggucg gggucauuuu                                                   20


<210>  7551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7551
gacuagcccc ugcaacugcc                                                   20


<210>  7552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7552
cgggccucag acuagccccu                                                   20


<210>  7553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7553
ucccgggccu cagacuagcc                                                   20


<210>  7554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7554
uucccagcuu aacuccuccc                                                   20


<210>  7555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7555
ucuugacagc cucuccuagc                                                   20


<210>  7556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7556
ugacagccuc uccuagcucu                                                   20


<210>  7557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7557
ccuagcucuu ugacuuuggg                                                   20


<210>  7558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7558
uagcucuuug acuuugggga                                                   20


<210>  7559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7559
uugacuuugg ggauggggga                                                   20


<210>  7560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7560
cuacaugaaa aggcuuugag                                                   20


<210>  7561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7561
aagccuuuuc auguagggag                                                   20


<210>  7562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7562
agcucaaagc cuuuucaugu                                                   20


<210>  7563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7563
ugucuccagc ucaaagccuu                                                   20


<210>  7564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7564
uccugugaau cuguccaggg                                                   20


<210>  7565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7565
gaccuagguu uccgccuccu                                                   20


<210>  7566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7566
uacaucugug ugauccgggg                                                   20


<210>  7567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7567
guguccagau gugugacggg                                                   20


<210>  7568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7568
cgucacacau cuggacacag                                                   20


<210>  7569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7569
acccuccgcu auugcaugac                                                   20


<210>  7570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7570
gcuauugcau gacagucagc                                                   20


<210>  7571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7571
gcuucgcuug guggagcgaa                                                   20


<210>  7572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7572
accaagcgaa gcagagcguc                                                   20


<210>  7573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7573
gugggugggg ccagcuggcc                                                   20


<210>  7574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7574
ggcaccggau acuccguggg                                                   20


<210>  7575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7575
gguccgucag cuucgucugc                                                   20


<210>  7576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7576
uuggccugcu gugguccguc                                                   20


<210>  7577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7577
augggacccc uaucaccucu                                                   20


<210>  7578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7578
ccagagaccu guacuaccuc                                                   20


<210>  7579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7579
agagaccugu acuaccucac                                                   20


<210>  7580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7580
ggagagguga uagggguccc                                                   20


<210>  7581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7581
cuguggaguc cucagagaag                                                   20


<210>  7582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7582
acagugaggu aguacagguc                                                   20


<210>  7583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7583
gagaaggaga gcugcagguc                                                   20


<210>  7584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7584
gaggacucca cagugaggua                                                   20


<210>  7585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7585
uucucugagg acuccacagu                                                   20


<210>  7586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7586
ccuucucuga ggacuccaca                                                   20


<210>  7587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7587
cacagcacua ccuacuccgg                                                   20


<210>  7588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7588
cacacagcac uaccuacucc                                                   20


<210>  7589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7589
cucacacagc acuaccuacu                                                   20


<210>  7590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7590
augucuuuaa aagccaugcc                                                   20


<210>  7591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7591
aggaagccuu ccuggguuuc                                                   20


<210>  7592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7592
uccaggaagc cuuccugggu                                                   20


<210>  7593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7593
gcugccaccu ccuccaggaa                                                   20


<210>  7594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7594
gcuugguaug ggacagaaua                                                   20


<210>  7595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7595
uuugaaauga aaaggacuaa                                                   20


<210>  7596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7596
cacccagcca ggcgugagug                                                   20


<210>  7597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7597
cgccuggcug ggugggagga                                                   20


<210>  7598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7598
gcuauuccug cucccaggca                                                   20


<210>  7599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7599
caggcaccuc agucucuggu                                                   20


<210>  7600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7600
gucucuggug gugcccgcug                                                   20


<210>  7601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7601
gguggugccc gcugugggua                                                   20


<210>  7602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7602
aggucagaaa uaaagccuuc                                                   20


<210>  7603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7603
gaauagcacc cagcauaccu                                                   20


<210>  7604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7604
ggaagcuccu aucuugagug                                                   20


<210>  7605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7605
uaucuugagu guaagucccc                                                   20


<210>  7606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7606
caccaccuuc ugucaccuua                                                   20


<210>  7607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7607
aagcaaacuu ccugcugugg                                                   20


<210>  7608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7608
ccggcaccug ugcccugccc                                                   20


<210>  7609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7609
uuuuacggau gaggagaaag                                                   20


<210>  7610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7610
uccguaaaau gaggauaaua                                                   20


<210>  7611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7611
ucauccguaa aaugaggaua                                                   20


<210>  7612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7612
uucuccucau ccguaaaaug                                                   20


<210>  7613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7613
gaaccucuuu cuccucaucc                                                   20


<210>  7614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7614
uggaaggagg caaguugggu                                                   20


<210>  7615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7615
guccugcccu caucugcaag                                                   20


<210>  7616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7616
ucugcaagga ugcugggagc                                                   20


<210>  7617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7617
cagcauccuu gcagaugagg                                                   20


<210>  7618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7618
gaggagggug aggacaggca                                                   20


<210>  7619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7619
gagcucccag cauccuugca                                                   20


<210>  7620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7620
ucugagcucc cagcauccuu                                                   20


<210>  7621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7621
cccuccucug agcucccagc                                                   20


<210>  7622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7622
gcuuccucgg cugucuucca                                                   20


<210>  7623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7623
gucacccugg ucugugauug                                                   20


<210>  7624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7624
caaucacaga ccagggugac                                                   20


<210>  7625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7625
cugcucccaa ucacagacca                                                   20


<210>  7626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7626
cagcaggcug cugugaggcu                                                   20


<210>  7627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7627
ccaucccugg agguaugcaa                                                   20


<210>  7628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7628
aucccuggag guaugcaagu                                                   20


<210>  7629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7629
agggauggag agcuuacaac                                                   20


<210>  7630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7630
acuugcauac cuccagggau                                                   20


<210>  7631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7631
uaagugggga ugucaaccac                                                   20


<210>  7632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7632
cggcuuccuc guaagugggg                                                   20


<210>  7633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7633
gccacuggga agcucacggc                                                   20


<210>  7634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7634
guaggguaug cagguggugu                                                   20


<210>  7635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7635
agggcuuccu ccguagggua                                                   20


<210>  7636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7636
auccacuugg cuccagggcu                                                   20


<210>  7637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7637
gcacccagcc cgccuggccu                                                   20


<210>  7638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7638
acccagcuau gagagcauca                                                   20


<210>  7639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7639
uagcugggug gaggccaggc                                                   20


<210>  7640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7640
cauagcuggg uggaggccag                                                   20


<210>  7641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7641
ugaugccguu ucugcggaga                                                   20


<210>  7642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7642
gcagaaacgg caucaagagc                                                   20


<210>  7643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7643
cugugucacc caggcuggag                                                   20


<210>  7644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7644
agccugggug acacagugag                                                   20


<210>  7645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7645
aucaugacuc gcugcagccu                                                   20


<210>  7646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7646
cugcagccuc uuccucccag                                                   20


<210>  7647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7647
uccucccagg cucaagagau                                                   20


<210>  7648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7648
caggcucaag agauccuccc                                                   20


<210>  7649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7649
agagauccuc ccaccucagc                                                   20


<210>  7650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7650
ugagccuggg aggaagaggc                                                   20


<210>  7651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7651
caccucagcc ucccaaguag                                                   20


<210>  7652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7652
gccucccaag uagcagaaac                                                   20


<210>  7653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7653
caaguagcag aaaccacaag                                                   20


<210>  7654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7654
cucugccuua gccuccucau                                                   20


<210>  7655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7655
cugccuuagc cuccucaucu                                                   20


<210>  7656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7656
gccuuagccu ccucaucugu                                                   20


<210>  7657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7657
ucaucuguaa aaugggaauu                                                   20


<210>  7658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7658
ucuguaaaau gggaauugag                                                   20


<210>  7659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7659
auucccauuu uacagaugag                                                   20


<210>  7660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7660
aagagcugau uugugaggau                                                   20


<210>  7661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7661
uugagggaau ccucaauucc                                                   20


<210>  7662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7662
caaaucagcu cuuugaggga                                                   20


<210>  7663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7663
cccucccccc accccccacu                                                   20


<210>  7664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7664
ccccaccccc cacuguggcu                                                   20


<210>  7665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7665
cagcucacuu ucaauaauga                                                   20


<210>  7666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7666
cuuucaauaa ugaaagccca                                                   20


<210>  7667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7667
aggcuccuag acuguccugg                                                   20


<210>  7668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7668
cccaagguca cuucacaccu                                                   20


<210>  7669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7669
ccuaacucac ccaaggucac                                                   20


<210>  7670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7670
uuaacucacc uaacucaccc                                                   20


<210>  7671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7671
uggucacacc agcaacucau                                                   20


<210>  7672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7672
ugugggcuuc caguuaggcc                                                   20


<210>  7673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7673
aggucaccag caucaugaaa                                                   20


<210>  7674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7674
uucaugaugc uggugaccuu                                                   20


<210>  7675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7675
gccucuuuca ugaugcuggu                                                   20


<210>  7676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7676
gcagcccuga cucagccucu                                                   20


<210>  7677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7677
cuuaccuucu ucaggacuuu                                                   20


<210>  7678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7678
cucccuuacc uucuucagga                                                   20


<210>  7679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7679
aggcagaagg aacagcaggu                                                   20


<210>  7680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7680
gcaccugcug uuccuucugc                                                   20


<210>  7681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7681
uccaucacac ccacauccua                                                   20


<210>  7682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7682
ccuccuccau cacacccaca                                                   20


<210>  7683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7683
cauaacccca uccuuccggu                                                   20


<210>  7684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7684
ccaggccugc cccucccaua                                                   20


<210>  7685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7685
gugccuuugc acaugcuggc                                                   20


<210>  7686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7686
gugccuagga gguuucuccu                                                   20


<210>  7687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7687
uaggcacaga ggccagcaug                                                   20


<210>  7688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7688
ugccccguca gaacuccaac                                                   20


<210>  7689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7689
augcuuaccu cugucaaaug                                                   20


<210>  7690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7690
gucaaauggg cgugcucuuu                                                   20


<210>  7691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7691
uucccucccu gccucggggu                                                   20


<210>  7692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7692
cugccucggg gugucauggg                                                   20


<210>  7693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7693
gggugucaug ggagcccgcu                                                   20


<210>  7694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7694
caugacaccc cgaggcaggg                                                   20


<210>  7695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7695
caaggauccc gaaagcuggg                                                   20


<210>  7696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7696
gcuggacgau gaaagacucc                                                   20


<210>  7697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7697
gcgcgcucug cuccccaguc                                                   20


<210>  7698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7698
gcuccccagu cccccaggug                                                   20


<210>  7699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7699
ccaguccccc agguggcccg                                                   20


<210>  7700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7700
gcaggcucgg uuuccucgcc                                                   20


<210>  7701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7701
guuuccucgc cugugaaaug                                                   20


<210>  7702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7702
ccugugaaau gcgggcgaug                                                   20


<210>  7703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7703
ccuccccgcc gcgacugcuc                                                   20


<210>  7704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7704
ccgccgcgac ugcucaucac                                                   20


<210>  7705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7705
gcgccgggcg gcccacgagg                                                   20


<210>  7706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7706
ugggccgccc ggcgcugagc                                                   20


<210>  7707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7707
auccccuuca cauucacacg                                                   20


<210>  7708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7708
uuggguuccu ccauccccuu                                                   20


<210>  7709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7709
aggccuggcc uccuuggguu                                                   20


<210>  7710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7710
cagauuuggu gcugucucca                                                   20


<210>  7711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7711
guaaaauggg aauaauaaug                                                   20


<210>  7712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7712
ucuguaaaau gggaauaaua                                                   20


<210>  7713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7713
guuuccuccu cuguaaaaug                                                   20


<210>  7714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7714
cagcugcaga acuguacccu                                                   20


<210>  7715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7715
gcugcagaac uguacccugu                                                   20


<210>  7716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7716
agaaaacagg guacaguucu                                                   20


<210>  7717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7717
caccuuccag cucuagaaaa                                                   20


<210>  7718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7718
accccacagu aggcaaauga                                                   20


<210>  7719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7719
uuugccuacu gugggguuga                                                   20


<210>  7720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7720
cacucucccu ccccugugug                                                   20


<210>  7721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7721
cucagauuca cacacacacu                                                   20


<210>  7722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7722
gauucacaca cacacuccag                                                   20


<210>  7723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7723
aggccagccg ggcccagagg                                                   20


<210>  7724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7724
gggcccggcu ggccuggagu                                                   20


<210>  7725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7725
ccuucccucu gggcccggcu                                                   20


<210>  7726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7726
caccuucccu cugggcccgg                                                   20


<210>  7727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7727
uugcccucuc accuucccuc                                                   20


<210>  7728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7728
cuucaacgga cccacaccca                                                   20


<210>  7729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7729
agcccuguug aacugguggg                                                   20


<210>  7730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7730
ucagccaugg cugccuggcc                                                   20


<210>  7731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7731
guacguuccu caugagccau                                                   20


<210>  7732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7732
ugagccauga ucggccccag                                                   20


<210>  7733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7733
ugaggaacgu accgagggcc                                                   20


<210>  7734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7734
agaugaugcc cccgaucacc                                                   20


<210>  7735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7735
ucccaucacu aaauuacaca                                                   20


<210>  7736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7736
caaaccagug cucuucccau                                                   20


<210>  7737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7737
ggacucccaa accagugcuc                                                   20


<210>  7738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7738
cuaugaccuu ugucuuucug                                                   20


<210>  7739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7739
augaccuuug ucuuucugag                                                   20


<210>  7740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7740
uggcauuucc auuccacaga                                                   20


<210>  7741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7741
aggcauugaa gauucgcaac                                                   20


<210>  7742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7742
cuaggcauug aagauucgca                                                   20


<210>  7743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7743
cugggucugu accugaccag                                                   20


<210>  7744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7744
uuuucucccu gggucuguac                                                   20


<210>  7745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7745
ccagcccugc ccccuccacg                                                   20


<210>  7746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7746
acgggccaac ccugggcugu                                                   20


<210>  7747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7747
agcacugaac agaaugacag                                                   20


<210>  7748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7748
gucugugcaa uuccuugagc                                                   20


<210>  7749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7749
aggaauugca cagacagagg                                                   20


<210>  7750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7750
gcucaaggaa uugcacagac                                                   20


<210>  7751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7751
cagugaccuc ugcucaagga                                                   20


<210>  7752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7752
ugucaccacu gcuauuauaa                                                   20


<210>  7753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7753
ccucuaccgu cacucccauc                                                   20


<210>  7754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7754
ccuccccucu accgucacuc                                                   20


<210>  7755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7755
ccuccccucc ccucuaccgu                                                   20


<210>  7756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7756
uccccucccc uccccucuac                                                   20


<210>  7757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7757
uuaauaccca gcaauauucc                                                   20


<210>  7758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7758
acagcacgug aacccaugaa                                                   20


<210>  7759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7759
uucauguccc acuucuguga                                                   20


<210>  7760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7760
uucugccaag gucacagaag                                                   20


<210>  7761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7761
cccucagcuc ugagccuugu                                                   20


<210>  7762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7762
gcucugagcc uuguacggcu                                                   20


<210>  7763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7763
gagccuugua cggcugauug                                                   20


<210>  7764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7764
gagcugaggg ggagggacuc                                                   20


<210>  7765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7765
gugaagccug uuuccucccc                                                   20


<210>  7766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7766
ccuucucugu gaagccuguu                                                   20


<210>  7767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7767
ccuacaaagc ccagcucacc                                                   20


<210>  7768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7768
uaucucaccu acaaagccca                                                   20


<210>  7769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7769
gcuuggugaa cucuuaucuc                                                   20


<210>  7770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7770
ccacugguau ggcugccccc                                                   20


<210>  7771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7771
ggucuuggug agagcugaca                                                   20


<210>  7772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7772
ccaagaccag agaagaagcc                                                   20


<210>  7773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7773
caccaagacc agagaagaag                                                   20


<210>  7774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7774
gggaauuggc aaaccucucc                                                   20


<210>  7775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7775
gugcaguuga ccaggguagg                                                   20


<210>  7776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7776
ccuuugcuug cagaucaccu                                                   20


<210>  7777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7777
uuugcuugca gaucaccuuc                                                   20


<210>  7778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7778
gacuuucaag gcauccucuc                                                   20


<210>  7779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7779
ccccaaaggc caugggccug                                                   20


<210>  7780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7780
ccaaaggcca ugggccugcu                                                   20


<210>  7781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7781
agcaggccca uggccuuugg                                                   20


<210>  7782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7782
gcagcaagcc cauucuccag                                                   20


<210>  7783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7783
ucaucucggc agcaagccca                                                   20


<210>  7784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7784
cgggagggga ggaguaagcc                                                   20


<210>  7785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7785
ggaggggagg aguaagcccc                                                   20


<210>  7786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7786
cgagagggcc uggcaccuac                                                   20


<210>  7787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7787
ccucccgaga gggccuggca                                                   20


<210>  7788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7788
uccccucccg agagggccug                                                   20


<210>  7789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7789
ccugacugag gagagugaga                                                   20


<210>  7790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7790
gucaggggag acuggccuau                                                   20


<210>  7791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7791
ucagucaggg gagacuggcc                                                   20


<210>  7792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7792
ccucagucag gggagacugg                                                   20


<210>  7793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7793
cucuccucag ucaggggaga                                                   20


<210>  7794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7794
cacucuccuc agucagggga                                                   20


<210>  7795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7795
cucucacucu ccucagucag                                                   20


<210>  7796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7796
cagaauugag aguugaaaac                                                   20


<210>  7797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7797
ucuguacaau gggaauaaua                                                   20


<210>  7798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7798
guuuccucau cuguacaaug                                                   20


<210>  7799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7799
ucccugacaa gacaaagucc                                                   20


<210>  7800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7800
augaaacaaa ucauacaaug                                                   20


<210>  7801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7801
uuauacagcu aggaagauug                                                   20


<210>  7802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7802
aucuuccuag cuguauaaag                                                   20


<210>  7803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7803
gagaagugua gucacuagcc                                                   20


<210>  7804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7804
gagccucaau cuuccuagcu                                                   20


<210>  7805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7805
uggggaguca gugauggaag                                                   20


<210>  7806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7806
ccaugagguu uggggcuagu                                                   20


<210>  7807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7807
cucccacucc agccccaguc                                                   20


<210>  7808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7808
cccacuccag ccccaguccc                                                   20


<210>  7809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7809
cacuccagcc ccagucccca                                                   20


<210>  7810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7810
agccccaguc cccagccgcc                                                   20


<210>  7811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7811
cacagccuua cauagggcgg                                                   20


<210>  7812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7812
ggucauaggc ggcuuccucc                                                   20


<210>  7813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7813
ugacuuucau cuggaugugg                                                   20


<210>  7814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7814
cuguagcuca ugacuuucau                                                   20


<210>  7815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7815
uugcuggccc cugagauggg                                                   20


<210>  7816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7816
ggggccagca aggagcggug                                                   20


<210>  7817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7817
aucacugguu cccagcuucg                                                   20


<210>  7818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7818
uccaucacug guucccagcu                                                   20


<210>  7819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7819
auccaggccu gaacgucgcc                                                   20


<210>  7820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7820
gacgagagug aaggggaaag                                                   20


<210>  7821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7821
ucugagcccu uguggaugac                                                   20


<210>  7822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7822
cgucugagcc cuuguggaug                                                   20


<210>  7823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7823
gagcuggccc gggugagugc                                                   20


<210>  7824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7824
gaguuaggcg ucuuuccccu                                                   20


<210>  7825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7825
cccgggccag cucugaguua                                                   20


<210>  7826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7826
aagcacucac ccgggccagc                                                   20


<210>  7827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7827
ugcccucuaa gcacucaccc                                                   20


<210>  7828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7828
ccuuaccccc agugucccca                                                   20


<210>  7829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7829
acugcccucu ccuuaccccc                                                   20


<210>  7830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7830
ggguguccca cacccuccac                                                   20


<210>  7831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7831
uuugucugcc acaucugcca                                                   20


<210>  7832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7832
caagcccaua cucauuuguc                                                   20


<210>  7833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7833
guucaaaccc cagcuccugu                                                   20


<210>  7834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7834
ugugcugugu agcuguggua                                                   20


<210>  7835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7835
guuuccccac acagggauga                                                   20


<210>  7836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7836
acauuccugg guaguaggaa                                                   20


<210>  7837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7837
gaaugcuugu cgugaguagc                                                   20


<210>  7838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7838
cgacaagcau ucagagacau                                                   20


<210>  7839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7839
uggcccccug cuacucacga                                                   20


<210>  7840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7840
ggcuccuggc ccccugcuac                                                   20


<210>  7841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7841
gguccucugg cuccuggccc                                                   20


<210>  7842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7842
gugaccuugg gcaaggcccu                                                   20


<210>  7843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7843
ccacuccacu cccaucccug                                                   20


<210>  7844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7844
acucccaucc cugucuguuu                                                   20


<210>  7845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7845
caucccuguc uguuugugaa                                                   20


<210>  7846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7846
guucacaaac agacagggau                                                   20


<210>  7847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7847
uuauucaucc auguacuuau                                                   20


<210>  7848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7848
guaaugugga uggaaugaau                                                   20


<210>  7849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7849
gggguagauu ccagugaagg                                                   20


<210>  7850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7850
ucagggguag auuccaguga                                                   20


<210>  7851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7851
gaguccaaug agggaggcaa                                                   20


<210>  7852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7852
gagcuccuca gggguagauu                                                   20


<210>  7853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7853
uuggacucag agcuccucag                                                   20


<210>  7854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7854
cucauuggac ucagagcucc                                                   20


<210>  7855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7855
guguaacugg gccuaugagc                                                   20


<210>  7856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7856
uaggcccagu uacacugagg                                                   20


<210>  7857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7857
guugcucaua ggcccaguua                                                   20


<210>  7858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7858
ucuguugcuc auaggcccag                                                   20


<210>  7859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7859
aauuauucag gguucuccuc                                                   20


<210>  7860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7860
ucuacuucuc caauuauuca                                                   20


<210>  7861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7861
ugaaauaggg cuauuacuau                                                   20


<210>  7862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7862
ugcaguucuu ucuuagguuu                                                   20


<210>  7863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7863
guuucuuccc aauaacagaa                                                   20


<210>  7864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7864
gagauacccu ugcccuugug                                                   20


<210>  7865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7865
gagucagaau gccugggucc                                                   20


<210>  7866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7866
agugaaggca gcagccccaa                                                   20


<210>  7867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7867
acaugacagg gaggaagcuu                                                   20


<210>  7868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7868
cugucaugug gagaugcauu                                                   20


<210>  7869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7869
gggcugcagg ugcccgcugg                                                   20


<210>  7870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7870
aacguugggg caucaaucag                                                   20


<210>  7871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7871
uccuccaacg uuggggcauc                                                   20


<210>  7872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7872
uggggcucau ccuccaacgu                                                   20


<210>  7873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7873
accuuugucc uuggguaccg                                                   20


<210>  7874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7874
uccaccuuug uccuugggua                                                   20


<210>  7875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7875
uucuccucca ccuuuguccu                                                   20


<210>  7876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7876
ccaccugugu ccgaagccuc                                                   20


<210>  7877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7877
gguuccuccc caccuguguc                                                   20


<210>  7878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7878
uccuucucag guuccucccc                                                   20


<210>  7879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7879
aucuggcagc ccauaguaca                                                   20


<210>  7880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7880
ucccggacaa ggagcugggu                                                   20


<210>  7881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7881
cggacaagga gcuggguuuu                                                   20


<210>  7882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7882
uuguccggga ggaggucccc                                                   20


<210>  7883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7883
aaacccagcu ccuuguccgg                                                   20


<210>  7884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7884
gccuugggug ucaggcucaa                                                   20


<210>  7885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7885
guagcuucua gucuggaacu                                                   20


<210>  7886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7886
acaaaucaua uuuugccuuc                                                   20


<210>  7887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7887
gagaggaacc uuccuuggug                                                   20


<210>  7888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7888
gaggucagcu uugggggaag                                                   20


<210>  7889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7889
cagaggucag cuuuggggga                                                   20


<210>  7890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7890
cucugggccc cugauccuuu                                                   20


<210>  7891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7891
gggccccuga uccuuuguga                                                   20


<210>  7892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7892
gcagcugcca ggauccuggg                                                   20


<210>  7893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7893
aaccaggacc acgcccucag                                                   20


<210>  7894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7894
gagccugcac ccugggccac                                                   20


<210>  7895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7895
gagggcgugg uccugguuug                                                   20


<210>  7896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7896
cagguggccc agggugcagg                                                   20


<210>  7897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7897
gacucccagg uggcccaggg                                                   20


<210>  7898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7898
acccagaacc ccauagccca                                                   20


<210>  7899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7899
acccggaagc ccuucccuag                                                   20


<210>  7900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7900
uucccuaggc caggaccccc                                                   20


<210>  7901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7901
gcagugaagg augccacagg                                                   20


<210>  7902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7902
cugcugucau gacucaggac                                                   20


<210>  7903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7903
gcugucauga cucaggacag                                                   20


<210>  7904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7904
ggacaggagu uccuggucac                                                   20


<210>  7905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7905
uguccugagu caugacagca                                                   20


<210>  7906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7906
gcugugacca ggaacuccug                                                   20


<210>  7907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7907
uccgaagacu cagcugugac                                                   20


<210>  7908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7908
ccucauccga agacucagcu                                                   20


<210>  7909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7909
ugugcucugu ugccuaaggc                                                   20


<210>  7910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7910
guugccuaag gcagggcagc                                                   20


<210>  7911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7911
gggcaggaua cgugaggccu                                                   20


<210>  7912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7912
cguauccugc cccgagggaa                                                   20


<210>  7913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7913
ggugcccguc aggcguaagg                                                   20


<210>  7914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7914
uccggaagua agcccucacu                                                   20


<210>  7915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7915
cugcaguggc augaccgugg                                                   20


<210>  7916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7916
ggagugauuc cccacacccc                                                   20


<210>  7917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7917
ugagauucag caccacacag                                                   20


<210>  7918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7918
uguuuaaguc uaaagccacu                                                   20


<210>  7919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7919
gguugcuggg ccugccagca                                                   20


<210>  7920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7920
agaacagggu uaccaucuuc                                                   20


<210>  7921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7921
acuaccccaa gcccccugca                                                   20


<210>  7922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7922
cuccacuacc ccaagccccc                                                   20


<210>  7923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7923
ccaucucacu ccacuacccc                                                   20


<210>  7924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7924
cuggcucuug cugcaugaug                                                   20


<210>  7925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7925
ugcugcauga uggggagacc                                                   20


<210>  7926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7926
ccaucaugca gcaagagcca                                                   20


<210>  7927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7927
gcuaaguuau uaggaggccc                                                   20


<210>  7928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7928
uaauaacuua gcagaggcag                                                   20


<210>  7929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7929
aagauaccuc auuuggauga                                                   20


<210>  7930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7930
uuuggaugau acaauguuac                                                   20


<210>  7931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7931
gugaccuuug acaagucugg                                                   20


<210>  7932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7932
guagcccuca gcuuucucau                                                   20


<210>  7933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7933
gcuuucucau gugcaaauga                                                   20


<210>  7934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7934
ugugcaaaug acagaugaag                                                   20


<210>  7935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7935
caguggucuu uggcugcagg                                                   20


<210>  7936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7936
ccugugguua acaagcuggg                                                   20


<210>  7937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7937
cccugguucg cugugguguu                                                   20


<210>  7938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7938
gaaagaggua uuagaaagga                                                   20


<210>  7939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7939
uucagagacu cccccugguu                                                   20


<210>  7940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7940
ccugucaggu uggagggacu                                                   20


<210>  7941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7941
ugucagguug gagggacucu                                                   20


<210>  7942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7942
aaccugacag gagagugacc                                                   20


<210>  7943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7943
ggaaguuucc acccucugga                                                   20


<210>  7944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7944
ggagagggaa aggcccugga                                                   20


<210>  7945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7945
agagggugga aacuuccaga                                                   20


<210>  7946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7946
ccagagggug gaaacuucca                                                   20


<210>  7947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7947
agggccuuuc ccucuccaga                                                   20


<210>  7948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7948
gccgaccgcu cgccaugacc                                                   20


<210>  7949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7949
ccaugaccuu ggguacauca                                                   20


<210>  7950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7950
cugggcuccu cuauucucug                                                   20


<210>  7951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7951
ucuauucucu guaaaauugg                                                   20


<210>  7952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7952
auucucugua aaauugggug                                                   20


<210>  7953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7953
guaaaauugg gugagggugg                                                   20


<210>  7954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7954
agaaucagaa agaccugguu                                                   20


<210>  7955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7955
cagagccuca auguccacau                                                   20


<210>  7956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7956
gagccucaau guccacauuu                                                   20


<210>  7957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7957
gagaggggcu gugacuuguc                                                   20


<210>  7958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7958
auguccacau uuaugcagug                                                   20


<210>  7959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7959
ccacugcaua aauguggaca                                                   20


<210>  7960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7960
cucuugggcu uuuguggaga                                                   20


<210>  7961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7961
ugggcuuuug uggagaagaa                                                   20


<210>  7962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7962
guggaaccuu gcugccugac                                                   20


<210>  7963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7963
cugugcuagu guggagggag                                                   20


<210>  7964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7964
acacuagcac agggagaugc                                                   20


<210>  7965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7965
cuccacacua gcacagggag                                                   20


<210>  7966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7966
ucccccagua ccuagcacag                                                   20


<210>  7967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7967
ggggaaugca aauuaaaaca                                                   20


<210>  7968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7968
accuauuauu aucuuuauua                                                   20


<210>  7969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7969
acauucugcc agcuccaccu                                                   20


<210>  7970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7970
guuccuccac auucugccag                                                   20


<210>  7971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7971
uucugacguu gcugauguga                                                   20


<210>  7972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7972
cucacucauu uaacaacaau                                                   20


<210>  7973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7973
uaauuauaca uuacaaaauc                                                   20


<210>  7974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7974
uucucuuaau uauacauuac                                                   20


<210>  7975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7975
cuuucucuua auuauacauu                                                   20


<210>  7976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7976
uuccuugauu uuguuuguga                                                   20


<210>  7977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7977
caaacaaaau caaggaagga                                                   20


<210>  7978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7978
cucacaaaca aaaucaagga                                                   20


<210>  7979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7979
gcugcuggag gugguccuga                                                   20


<210>  7980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7980
agcagcagag aaaaggauug                                                   20


<210>  7981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7981
ggaccaccuc cagcagcaga                                                   20


<210>  7982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7982
aucucaggac caccuccagc                                                   20


<210>  7983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7983
uuaggucuua cuggccagaa                                                   20


<210>  7984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7984
agccacuaca ucuguuuuca                                                   20


<210>  7985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7985
ugacugcaag acagcugcug                                                   20


<210>  7986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7986
uggaauuucc cucaugacug                                                   20


<210>  7987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7987
gugaaucucu uggaauuucc                                                   20


<210>  7988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7988
gcuuucugaa aauauguauu                                                   20


<210>  7989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7989
ucccacaaca aauccagguc                                                   20


<210>  7990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7990
aggucauuuu caugcagaug                                                   20


<210>  7991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7991
aauuuuccuc aaggucauuu                                                   20


<210>  7992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7992
uccaauuuuc cucaagguca                                                   20


<210>  7993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7993
ccuccaauuu uccucaaggu                                                   20


<210>  7994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7994
uggggaccuc agugguuguu                                                   20


<210>  7995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7995
gugguuguug cugggcuggg                                                   20


<210>  7996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7996
aaaacccagc ccagcaacaa                                                   20


<210>  7997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7997
cuggcugaga uggcugacuu                                                   20


<210>  7998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7998
gccagggagg aaggucagau                                                   20


<210>  7999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  7999
gcaccauuaa cacccugacg                                                   20


<210>  8000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8000
ucaggguguu aauggugcag                                                   20


<210>  8001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8001
ucgucagggu guuaauggug                                                   20


<210>  8002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8002
ccccuaggcc aaaauauuuc                                                   20


<210>  8003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8003
cgguccccac cuccacuugc                                                   20


<210>  8004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8004
acuugcccug gggcccgggc                                                   20


<210>  8005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8005
gagcacugau gcaaaucggg                                                   20


<210>  8006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8006
gagguccagg gugaaaggaa                                                   20


<210>  8007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8007
acacaaauac ccaacugggu                                                   20


<210>  8008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8008
uccacacaaa uacccaacug                                                   20


<210>  8009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8009
gaucccgucc uuccuccccc                                                   20


<210>  8010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8010
cccuccaugc uugccucaug                                                   20


<210>  8011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8011
augcuugccu caugucagga                                                   20


<210>  8012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8012
ugucaggacu uucuaaagca                                                   20


<210>  8013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8013
ucagugaggg gagagugauu                                                   20


<210>  8014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8014
gugaggggag agugauugcc                                                   20


<210>  8015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8015
cugaggagau gcaaagucca                                                   20


<210>  8016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8016
ccucacugag gagaugcaaa                                                   20


<210>  8017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8017
ccccucacug aggagaugca                                                   20


<210>  8018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8018
ucagcagaac aguggcaauc                                                   20


<210>  8019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8019
guucacucau cagcagaaca                                                   20


<210>  8020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8020
gaaaggggca aguuguugcc                                                   20


<210>  8021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8021
gcuacaaauu cacgguguga                                                   20


<210>  8022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8022
uguucuggau cuccgccugg                                                   20


<210>  8023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8023
gccugggucg ugucccaucu                                                   20


<210>  8024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8024
acaacauccc cuucccccuu                                                   20


<210>  8025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8025
ucaugauagc cacugucacc                                                   20


<210>  8026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8026
ugauagccac ugucaccacc                                                   20


<210>  8027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8027
agccugugcu cauuaucaca                                                   20


<210>  8028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8028
uuaucacaug gccccucaca                                                   20


<210>  8029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8029
caggguacug ucuccaggcu                                                   20


<210>  8030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8030
aggcuggacc ccaccacacc                                                   20


<210>  8031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8031
ggugggugug guggggucca                                                   20


<210>  8032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8032
uaagugguag uugggcucua                                                   20


<210>  8033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8033
aaaaccacuc ucuccagacc                                                   20


<210>  8034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8034
cuccagacca aagcgaauug                                                   20


<210>  8035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8035
ccagaccaaa gcgaauugga                                                   20


<210>  8036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8036
agaccaaagc gaauuggacu                                                   20


<210>  8037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8037
uacagcuggg acccccuuua                                                   20


<210>  8038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8038
ugguccagca gaagagauug                                                   20


<210>  8039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8039
ucugcuggac caggagcucc                                                   20


<210>  8040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8040
augugacaau cucuucugcu                                                   20


<210>  8041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8041
cuuggcaaag agaagagggg                                                   20


<210>  8042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8042
uugccaaggg aguccucuau                                                   20


<210>  8043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8043
ucucuuugcc aagggagucc                                                   20


<210>  8044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8044
cugaacuuuc ugcccuaugu                                                   20


<210>  8045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8045
aggcagcacu cccugaacuu                                                   20


<210>  8046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8046
uccaggcagc acucccugaa                                                   20


<210>  8047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8047
uccuccaggc agcacucccu                                                   20


<210>  8048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8048
ugacacccac cccaaggguc                                                   20


<210>  8049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8049
uggaaugccc uucccagcau                                                   20


<210>  8050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8050
ugcuaugccu uccuccugga                                                   20


<210>  8051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8051
gcagccaugg cucaugcuau                                                   20


<210>  8052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8052
acucugcagc cauggcucau                                                   20


<210>  8053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8053
agcaguccag gucacccagc                                                   20


<210>  8054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8054
cugaaaaugu agcacugccu                                                   20


<210>  8055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8055
ugaggaguuu augaaaugca                                                   20


<210>  8056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8056
ggagauacca aagcagcccu                                                   20


<210>  8057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8057
ucaggagaua ccaaagcagc                                                   20


<210>  8058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8058
aggaacuggg cccaggaauc                                                   20


<210>  8059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8059
gccuggccca gaaucuccag                                                   20


<210>  8060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8060
aagcgggagg guaggaggag                                                   20


<210>  8061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8061
cgcuuugaga auugcagauu                                                   20


<210>  8062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8062
uacccucccg cuuugagaau                                                   20


<210>  8063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8063
uccuacccuc ccgcuuugag                                                   20


<210>  8064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8064
uuccaccacu cugaugcagg                                                   20


<210>  8065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8065
gaugcaggug gccccugggc                                                   20


<210>  8066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8066
aagcauggcc caggggccac                                                   20


<210>  8067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8067
guccugcuag uguuucucca                                                   20


<210>  8068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8068
guccaaggcc accucagucc                                                   20


<210>  8069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8069
acagugcucu guccaaggcc                                                   20


<210>  8070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8070
accccagacc ccuccacagu                                                   20


<210>  8071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8071
gccuccaccc cagaccccuc                                                   20


<210>  8072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8072
accucugccu ccaccccaga                                                   20


<210>  8073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8073
uccuacagcg cacuccaccu                                                   20


<210>  8074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8074
uggacaagcc uauugaaaag                                                   20


<210>  8075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8075
uuucaucauu cucuagugcu                                                   20


<210>  8076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8076
agugcucuua ucaccaacuu                                                   20


<210>  8077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8077
uaucaccaac uuauaggcug                                                   20


<210>  8078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8078
acuaugaggg cugcaugaga                                                   20


<210>  8079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8079
uaguugagug aaacagguaa                                                   20


<210>  8080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8080
ugcagcccuc auaguugagu                                                   20


<210>  8081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8081
cuugaucacc uuccauguua                                                   20


<210>  8082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8082
aaaagaaaaa aaaugcaaac                                                   20


<210>  8083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8083
aucucaaaaa gaaaaaaaau                                                   20


<210>  8084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8084
cucuugucac ccaggaugaa                                                   20


<210>  8085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8085
ugucacccag gaugaagugc                                                   20


<210>  8086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8086
gcucaccaca accuccgccu                                                   20


<210>  8087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8087
ccacaaccuc cgccucccag                                                   20


<210>  8088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8088
gccucccagg uucaagcgau                                                   20


<210>  8089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8089
cagguucaag cgauucucug                                                   20


<210>  8090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8090
gccucagccu accgaguagc                                                   20


<210>  8091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8091
gccuaccgag uagcugggau                                                   20


<210>  8092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8092
guaggcugag gcagagaauc                                                   20


<210>  8093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8093
acuaaaaaca caaaauuagc                                                   20


<210>  8094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8094
auguugguca ggcuggucuu                                                   20


<210>  8095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8095
ugacuucagg ugauccaccc                                                   20


<210>  8096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8096
gccucccaac guguuaggau                                                   20


<210>  8097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8097
caacguguua ggauuacagg                                                   20


<210>  8098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8098
caccuguaau ccuaacacgu                                                   20


<210>  8099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8099
uccacccuaa aaaaacaaaa                                                   20


<210>  8100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8100
gaucucuucc acccuaaaaa                                                   20


<210>  8101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8101
gcacgcucag aucucuucca                                                   20


<210>  8102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8102
cagcacgcuc agaucucuuc                                                   20


<210>  8103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8103
cccuuuuucc ugccagccuc                                                   20


<210>  8104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8104
uuuguacaca ucaaggcuua                                                   20


<210>  8105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8105
cuuuuguaca caucaaggcu                                                   20


<210>  8106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8106
gucucucuuu uguacacauc                                                   20


<210>  8107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8107
cugucucucu uuuguacaca                                                   20


<210>  8108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8108
cucugucucu cuuuuguaca                                                   20


<210>  8109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8109
gacaugucug ccuggcucuc                                                   20


<210>  8110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8110
ucccuuuaag ccggcaggga                                                   20


<210>  8111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8111
cugccggcuu aaagggaaga                                                   20


<210>  8112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8112
acccuguaug uccccacucc                                                   20


<210>  8113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8113
ccacccugua uguccccacu                                                   20


<210>  8114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8114
uuuucuccau gaaguggcag                                                   20


<210>  8115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8115
augaaguggc agacaagggg                                                   20


<210>  8116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8116
ucccaggaag ccccuugucu                                                   20


<210>  8117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8117
cuucccagga agccccuugu                                                   20


<210>  8118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8118
ccucucuucc caggaagccc                                                   20


<210>  8119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8119
uccccucucu ucccaggaag                                                   20


<210>  8120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8120
ccuccccucu cuucccagga                                                   20


<210>  8121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8121
ucuccucccc ucucuuccca                                                   20


<210>  8122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8122
ccucuccucc ccucucuucc                                                   20


<210>  8123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8123
acccucuccu cuccuccccu                                                   20


<210>  8124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8124
gggcccaaug cacaucacca                                                   20


<210>  8125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8125
agaauggcuc ugggcccaau                                                   20


<210>  8126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8126
accugcucaa gaauggcucu                                                   20


<210>  8127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8127
ccaccugcuc aagaauggcu                                                   20


<210>  8128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8128
aaaaugcuuu ccucuccacc                                                   20


<210>  8129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8129
uuuguucaga aucucccaga                                                   20


<210>  8130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8130
cagagucccc uaaccucagg                                                   20


<210>  8131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8131
gggagauucu gaacaaaaga                                                   20


<210>  8132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8132
ggagagggcc augccuuggc                                                   20


<210>  8133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8133
ugagguuagg ggacucuggg                                                   20


<210>  8134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8134
ccugagguua ggggacucug                                                   20


<210>  8135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8135
agaggcguua aaaaccagcc                                                   20


<210>  8136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8136
aggccaaggc auggcccucu                                                   20


<210>  8137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8137
cgaggccaag gcauggcccu                                                   20


<210>  8138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8138
caucucagug ucuccagcug                                                   20


<210>  8139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8139
gugucuccag cugggccaug                                                   20


<210>  8140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8140
agcugggcca ugcacugcuu                                                   20


<210>  8141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8141
ggaucugugg uccaguuaua                                                   20


<210>  8142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8142
aggaagccgg cccggauuca                                                   20


<210>  8143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8143
gucagauggg cacugaaucc                                                   20


<210>  8144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8144
cagaagggac aggcuaggug                                                   20


<210>  8145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8145
ucuugccucc uaucacaguc                                                   20


<210>  8146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8146
ugccuccuau cacagucgcc                                                   20


<210>  8147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8147
uaucacaguc gccugugcuc                                                   20


<210>  8148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8148
caucugccuc ccuguggacu                                                   20


<210>  8149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8149
ucugccuccc uguggacucu                                                   20


<210>  8150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8150
cuguggacuc ugaggaugag                                                   20


<210>  8151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8151
gaggaugagg cgagggcuga                                                   20


<210>  8152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8152
gaguccacag ggaggcagau                                                   20


<210>  8153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8153
uccucagagu ccacagggag                                                   20


<210>  8154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8154
ccucauccuc agaguccaca                                                   20


<210>  8155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8155
ggggugagag caggugccag                                                   20


<210>  8156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8156
ccccugagcu gaaucagccc                                                   20


<210>  8157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8157
caccccugag cugaaucagc                                                   20


<210>  8158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8158
gaugacaggu accuggcgcc                                                   20


<210>  8159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8159
gcuggucuag cugggcaagg                                                   20


<210>  8160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8160
agaguggccg gaagcuuccu                                                   20


<210>  8161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8161
ggagcagcag ccuugcccag                                                   20


<210>  8162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8162
caggaagcuu ccggccacuc                                                   20


<210>  8163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8163
cccaggaagc uuccggccac                                                   20


<210>  8164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8164
gggccugucc cucucucccu                                                   20


<210>  8165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8165
cucccuauuc cuuccuuccu                                                   20


<210>  8166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8166
cccuauuccu uccuuccucc                                                   20


<210>  8167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8167
cuauuccuuc cuuccucccu                                                   20


<210>  8168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8168
cuuccugaaa cugcguccuc                                                   20


<210>  8169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8169
aaauccugcu ccagcaccag                                                   20


<210>  8170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8170
agcaccagca acccccugcu                                                   20


<210>  8171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8171
ggcagcguuu cggucccuuu                                                   20


<210>  8172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8172
ggcgggggga aaggacugca                                                   20


<210>  8173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8173
caggcggggg gaaaggacug                                                   20


<210>  8174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8174
uugcucucag ugccccacuc                                                   20


<210>  8175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8175
cagugcccca cucucuggau                                                   20


<210>  8176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8176
gugccccacu cucuggauca                                                   20


<210>  8177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8177
cuggaucauu guccuucucu                                                   20


<210>  8178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8178
ggaucauugu ccuucucucc                                                   20


<210>  8179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8179
ccuccauaaa cgcagucaug                                                   20


<210>  8180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8180
uccauaaacg cagucaugcg                                                   20


<210>  8181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8181
auaaacgcag ucaugcgcca                                                   20


<210>  8182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8182
guuguaaucu uauggaacca                                                   20


<210>  8183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8183
gcucuguugu aaucuuaugg                                                   20


<210>  8184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8184
ugucaccucg cuuagagacg                                                   20


<210>  8185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8185
cuuagagacg ucauagcugu                                                   20


<210>  8186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8186
aagcgaggug acaggaguuu                                                   20


<210>  8187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8187
gagcccaagc caagccaucg                                                   20


<210>  8188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8188
gaggccugac agcuaugacg                                                   20


<210>  8189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8189
aaaagcaccu ccacugagca                                                   20


<210>  8190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8190
acugagcacc uugcgacccc                                                   20


<210>  8191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8191
guggaggugc uuuuugagcc                                                   20


<210>  8192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8192
uacccgccag agaacaaacc                                                   20


<210>  8193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8193
ggcggguagg aguggggguc                                                   20


<210>  8194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8194
cuucgcugac ucucuuuuug                                                   20


<210>  8195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8195
cuuuuuggac ucagcccgcc                                                   20


<210>  8196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8196
uuuuggacuc agcccgccug                                                   20


<210>  8197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8197
gcccgccugc acccagguga                                                   20


<210>  8198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8198
cacaaagccu guuugguggu                                                   20


<210>  8199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8199
ucacacggau gcacauguaa                                                   20


<210>  8200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8200
gaucggggga ccucccuugg                                                   20


<210>  8201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8201
cuugggagau caauccccug                                                   20


<210>  8202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8202
caagggaggu cccccgaucc                                                   20


<210>  8203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8203
ugcucuuugc uccaugagaa                                                   20


<210>  8204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8204
uugcuccaug agaaagaucc                                                   20


<210>  8205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8205
augagaaaga uccaccuacg                                                   20


<210>  8206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8206
uggagcaaag agcaggagga                                                   20


<210>  8207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8207
gguccucaga ccgaccagcc                                                   20


<210>  8208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8208
gaccgaccag cccaagaaac                                                   20


<210>  8209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8209
ccaauuucaa guccgguaag                                                   20


<210>  8210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8210
uuuuacucuc uucuccaacc                                                   20


<210>  8211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8211
cuucuccaac cucccucacu                                                   20


<210>  8212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8212
ucuccaaccu cccucacuau                                                   20


<210>  8213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8213
aaccucccuc acuaucccuc                                                   20


<210>  8214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8214
cucacuaucc cucaaccucu                                                   20


<210>  8215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8215
cuaucccuca accucuuucu                                                   20


<210>  8216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8216
accucuuucu ccuuucaauc                                                   20


<210>  8217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8217
uucuccuuuc aaucuuggcg                                                   20


<210>  8218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8218
uuucaaucuu ggcgccacac                                                   20


<210>  8219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8219
cccuucucuu aauuucaauu                                                   20


<210>  8220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8220
cuucucuuaa uuucaauuuc                                                   20


<210>  8221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8221
uaauuucaau uucuuucauu                                                   20


<210>  8222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8222
accaaaaaau gaaagaaauu                                                   20


<210>  8223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8223
uuugucucua ccaaaaaaug                                                   20


<210>  8224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8224
cugauuaucc acucacguuu                                                   20


<210>  8225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8225
gauuauccac ucacguuuca                                                   20


<210>  8226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8226
cguuucaagg gugucagacc                                                   20


<210>  8227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8227
uaucucugug ccccaauccc                                                   20


<210>  8228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8228
gugccccaau cccuuauuuc                                                   20


<210>  8229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8229
uaucucugug ccccaauccc                                                   20


<210>  8230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8230
gugccccaau cccuuauuuc                                                   20


<210>  8231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8231
cugcuuuucu ggagggcaag                                                   20


<210>  8232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8232
gcuuuucugg agggcaagaa                                                   20


<210>  8233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8233
agaaaagcag agaggggguu                                                   20


<210>  8234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8234
ccuccuccgu gucucuacgc                                                   20


<210>  8235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8235
uccgugucuc uacgcucucu                                                   20


<210>  8236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8236
gugucucuac gcucucuuuu                                                   20


<210>  8237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8237
acgcucucuu uucucagggu                                                   20


<210>  8238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8238
cuuuucucag gguuugccuc                                                   20


<210>  8239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8239
uuucucaggg uuugccuccu                                                   20


<210>  8240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8240
ggguuugccu ccuucacuau                                                   20


<210>  8241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8241
uucacuaugg gcaaccuucc                                                   20


<210>  8242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8242
auuccuccuu cuucuccuuu                                                   20


<210>  8243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8243
uucuucuccu uuagccugug                                                   20


<210>  8244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8244
uuuagccugu guccuuaaga                                                   20


<210>  8245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8245
ucaacucaca ccugaccuaa                                                   20


<210>  8246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8246
caccugaccu aaaaccuaaa                                                   20


<210>  8247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8247
gaccauuugc ccauuuuucg                                                   20


<210>  8248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8248
cuagccucug uucccaaugc                                                   20


<210>  8249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8249
guucccaaug caauuccucc                                                   20


<210>  8250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8250
cagauccucc uucuuucccu                                                   20


<210>  8251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8251
uucuuucccu cccgccuguc                                                   20


<210>  8252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8252
cgccuguccc cucaguccca                                                   20


<210>  8253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8253
gucccaaccc caagcgucgc                                                   20


<210>  8254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8254
gcgacgcuug ggguugggac                                                   20


<210>  8255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8255
uccccaggcu gcucaucacc                                                   20


<210>  8256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8256
ccaggcugcu caucaccagg                                                   20


<210>  8257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8257
ucaccaggcc gagcuaaguc                                                   20


<210>  8258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8258
gccuggugau gagcagccug                                                   20


<210>  8259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8259
gccuccgcuc cuccacccua                                                   20


<210>  8260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8260
gcuccuccac ccuauaaucc                                                   20


<210>  8261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8261
uccacccuau aauccuuuua                                                   20


<210>  8262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8262
acccuauaau ccuuuuauca                                                   20


<210>  8263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8263
ccuccucaca cccgauccgg                                                   20


<210>  8264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8264
ucacacccga uccggcucac                                                   20


<210>  8265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8265
cacccgaucc ggcucacagu                                                   20


<210>  8266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8266
caguuucguu ccgugacugg                                                   20


<210>  8267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8267
cccaccugcc cagcaauuua                                                   20


<210>  8268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8268
uaaaaaggug gauggagcca                                                   20


<210>  8269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8269
auccaccuuu uuaagaguaa                                                   20


<210>  8270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8270
uuuuucuuua ucccaaauca                                                   20


<210>  8271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8271
uuuucaucaa auauaaaaau                                                   20


<210>  8272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8272
uuuggcagca acccugagac                                                   20


<210>  8273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8273
ggguugcugc caaacgaguc                                                   20


<210>  8274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8274
auacucauuu uauuacccaa                                                   20


<210>  8275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8275
uuuuauuacc caauccacuc                                                   20


<210>  8276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8276
ugacauuaaa uaaaacucca                                                   20


<210>  8277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8277
aaaaauuaaa uuccagcccu                                                   20


<210>  8278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8278
aaccucacaa caggauuuaa                                                   20


<210>  8279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8279
caacaggauu uaauuaaccu                                                   20


<210>  8280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8280
ccuucaaggu gugcaauaau                                                   20


<210>  8281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8281
acugugagac aaaccccagc                                                   20


<210>  8282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8282
caguggaggc aaggaauugc                                                   20


<210>  8283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8283
agcacacaag aacuuccaaa                                                   20


<210>  8284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8284
agaaccuccu cccccaggag                                                   20


<210>  8285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8285
ucccccagga guuugcuaca                                                   20


<210>  8286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8286
cccaggaguu ugcuacaagu                                                   20


<210>  8287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8287
ugggggagga gguucuggag                                                   20


<210>  8288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8288
uaagccgcgu cccaucugug                                                   20


<210>  8289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8289
ccuggcagcc acucccagag                                                   20


<210>  8290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8290
cagagccccu ggaacucugg                                                   20


<210>  8291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8291
gggaguggcu gccaggugag                                                   20


<210>  8292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8292
ggcccaaggc ucucugacug                                                   20


<210>  8293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8293
cugacugacu ccuucccaga                                                   20


<210>  8294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8294
gacugacucc uucccagauc                                                   20


<210>  8295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8295
uucccagauc uucucggcuu                                                   20


<210>  8296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8296
gcuuagcggc ugaagacuga                                                   20


<210>  8297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8297
gaagccccca gaccaucacg                                                   20


<210>  8298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8298
gcguccguga uggucugggg                                                   20


<210>  8299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8299
cacaguggaa gguaagcccg                                                   20


<210>  8300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8300
caguggaagg uaagcccguc                                                   20


<210>  8301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8301
guauugauua agaaggggac                                                   20


<210>  8302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8302
cuccacauua ccuucuuuuc                                                   20


<210>  8303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8303
acauuaccuu cuuuucaagg                                                   20


<210>  8304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8304
auaacuguug uggguauuga                                                   20


<210>  8305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8305
uaaaacuccc caacucuggu                                                   20


<210>  8306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8306
ccaacucugg ugccaacuua                                                   20


<210>  8307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8307
ggugccaacu uagacaauac                                                   20


<210>  8308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8308
uuuaagcacu ccuuuuuagu                                                   20


<210>  8309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8309
uuuuuaguua uccccaccug                                                   20


<210>  8310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8310
gccuaauaag ggaacugggc                                                   20


<210>  8311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8311
uugccgcccu ucuucccaau                                                   20


<210>  8312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8312
uuuguguccu ccucuuguac                                                   20


<210>  8313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8313
ucuuguaccc cccaccuuaa                                                   20


<210>  8314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8314
uguacccccc accuuaaccc                                                   20


<210>  8315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8315
acucccuccu ugguggccaa                                                   20


<210>  8316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8316
cuccuuggug gccaaucaug                                                   20


<210>  8317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8317
uugguggcca aucaugcacc                                                   20


<210>  8318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8318
uuaaaaccua aucacccuua                                                   20


<210>  8319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8319
augccaauau cccaucccgc                                                   20


<210>  8320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8320
ccuuacaauu cccccauuuu                                                   20


<210>  8321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8321
uuacaauucc cccauuuuac                                                   20


<210>  8322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8322
ccuauccuca auaccugccu                                                   20


<210>  8323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8323
uauccucaau accugccucu                                                   20


<210>  8324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8324
auaccugccu cuauaaccca                                                   20


<210>  8325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8325
auaacccauu auucuguucu                                                   20


<210>  8326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8326
aacaugcuuu cuuuacuauu                                                   20


<210>  8327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8327
cuucacuuuc acuuugacug                                                   20


<210>  8328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8328
ucacuuucac uuugacugac                                                   20


<210>  8329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8329
gcacauuacc uaggcuguac                                                   20


<210>  8330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8330
ucuguuaccu aucuuggcgu                                                   20


<210>  8331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8331
uaaaaacaca ugugcucucc                                                   20


<210>  8332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8332
cccugccaau cguguccgac                                                   20


<210>  8333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8333
cugccaaucg uguccgacug                                                   20


<210>  8334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8334
caaaccccag caccuucuac                                                   20


<210>  8335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8335
aaccccagca ccuucuacaa                                                   20


<210>  8336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8336
uuuccuuccu aggcaugguu                                                   20


<210>  8337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8337
uguguaagaa uucugaccac                                                   20


<210>  8338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8338
ugucugcgug cagcggcugc                                                   20


<210>  8339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8339
aaaaguauua aagcaguggc                                                   20


<210>  8340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8340
aaaucacaaa cuaugcucaa                                                   20


<210>  8341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8341
acucacucuc uacauuucuc                                                   20


<210>  8342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8342
cucucuacau uucucauaac                                                   20


<210>  8343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8343
cuacauuucu cauaacuucc                                                   20


<210>  8344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8344
acauuucuca uaacuuccaa                                                   20


<210>  8345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8345
uaacuuccaa aaucuauuuu                                                   20


<210>  8346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8346
uaccugacac auauacuuuc                                                   20


<210>  8347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8347
uucagcugua cucacucuuu                                                   20


<210>  8348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8348
cucuuuguua acucccacaa                                                   20


<210>  8349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8349
uuguuaacuc ccacaauuac                                                   20


<210>  8350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8350
cacaauuacc guuguuccug                                                   20


<210>  8351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8351
aucuggccuc ccacauuauu                                                   20


<210>  8352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8352
cacauuauuc cugauaccac                                                   20


<210>  8353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8353
cugauccacc ugacauucac                                                   20


<210>  8354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8354
gauccaccug acauucaccc                                                   20


<210>  8355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8355
cccugaucau gcuugauuua                                                   20


<210>  8356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8356
uagaaccucu cauuuccuuu                                                   20


<210>  8357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8357
cauuuccuuu ccaucaugga                                                   20


<210>  8358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8358
uuuccuuucc aucauggaaa                                                   20


<210>  8359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8359
aggaaauaac uucucagugu                                                   20


<210>  8360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8360
guguuccauc ugcuauucua                                                   20


<210>  8361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8361
ucagggauua uucaggaccc                                                   20


<210>  8362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8362
gggauuauuc aggaccccuc                                                   20


<210>  8363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8363
cuucccuaca caucaagcuc                                                   20


<210>  8364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8364
aggauuugcc ccacccagga                                                   20


<210>  8365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8365
agcuugaugu guagggaagg                                                   20


<210>  8366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8366
acaugccuga gucagauaac                                                   20


<210>  8367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8367
ggcauguuga guaaagcuaa                                                   20


<210>  8368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8368
uagucuggag guauuuuagu                                                   20


<210>  8369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8369
agacuaagag guauuuuagu                                                   20


<210>  8370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8370
gacccuguag gaaaggccag                                                   20


<210>  8371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8371
ucccuucugu cagacacaau                                                   20


<210>  8372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8372
guuuagccuu cccaccucaa                                                   20


<210>  8373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8373
auacagucug auaacagaug                                                   20


<210>  8374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8374
ucuguuauca gacuguauug                                                   20


<210>  8375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8375
uaguauucag ugaaaccuuu                                                   20


<210>  8376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8376
gucuucaaga aaaguagaac                                                   20


<210>  8377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8377
ccaagcucag ccaccaaaaa                                                   20


<210>  8378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8378
gccaccaaaa aggacuggac                                                   20


<210>  8379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8379
gaauucaggc cuguccucgg                                                   20


<210>  8380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8380
gaaugcuaca agguacagcc                                                   20


<210>  8381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8381
uguauagacg cuccuuuuua                                                   20


<210>  8382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8382
uuuuuauuag gccccagucu                                                   20


<210>  8383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8383
uuccagacac cagaccaacu                                                   20


<210>  8384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8384
uauucaccgu ucucaacuac                                                   20


<210>  8385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8385
acuacucaua caugcccugc                                                   20


<210>  8386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8386
uacaugcccu gcucuuguuu                                                   20


<210>  8387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8387
uguuuacacu gccgguuuac                                                   20


<210>  8388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8388
aagccaucac agcugauauc                                                   20


<210>  8389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8389
cggugguauc ccaaaacugc                                                   20


<210>  8390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8390
uaacucuuga aguaaauaaa                                                   20


<210>  8391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8391
ugaaguaaau aaauaaucuu                                                   20


<210>  8392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8392
uuaggcacuc ucuaauuaga                                                   20


<210>  8393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8393
cuaauuagau guccuagguc                                                   20


<210>  8394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8394
aauuagaugu ccuagguccu                                                   20


<210>  8395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8395
caauucuuag uccuuuuaua                                                   20


<210>  8396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8396
uucucuuauu ccauuuaguu                                                   20


<210>  8397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8397
uauuccauuu aguuuuucaa                                                   20


<210>  8398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8398
cuucagcuua aucucuccca                                                   20


<210>  8399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8399
cccauucuag guucccacgc                                                   20


<210>  8400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8400
cauucuaggu ucccacgccg                                                   20


<210>  8401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8401
gggcugcuuc aagcgggauu                                                   20


<210>  8402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8402
cuccauacca ccccccaaaa                                                   20


<210>  8403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8403
ccauaccacc ccccaaaaau                                                   20


<210>  8404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8404
auaccacccc ccaaaaauuu                                                   20


<210>  8405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8405
gagcccaagc cacgccaucg                                                   20


<210>  8406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8406
gaggccugac auuccugccu                                                   20


<210>  8407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8407
aaaagcaccc ccacugagca                                                   20


<210>  8408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8408
gugggggugc uuuuugagcc                                                   20


<210>  8409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8409
ugcccacuga gcaccuugcg                                                   20


<210>  8410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8410
gugggcagga gugggggucg                                                   20


<210>  8411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8411
uacccgccag auaacaaacc                                                   20


<210>  8412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8412
cuucgcugac ucucuuuucg                                                   20


<210>  8413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8413
cuuuucggac ucagcccacc                                                   20


<210>  8414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8414
uuucggacuc agcccaccug                                                   20


<210>  8415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8415
gcccaccugc acccagguga                                                   20


<210>  8416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8416
ucacacggac gcgcaugaaa                                                   20


<210>  8417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8417
ccacucacuc acugacaccc                                                   20


<210>  8418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8418
cucacugaca cccagagcca                                                   20


<210>  8419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8419
cugacaccca gagccacuuc                                                   20


<210>  8420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8420
gggugucagu gagugagugg                                                   20


<210>  8421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8421
guucaugcua agugcccuac                                                   20


<210>  8422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8422
uuuacauuuu auuuuuacua                                                   20


<210>  8423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8423
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  8424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8424
gucucaaaaa aaaaaaaaaa                                                   20


<210>  8425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8425
cucuguugcc caggguggag                                                   20


<210>  8426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8426
guugcccagg guggagugca                                                   20


<210>  8427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8427
acccugggca acagagugag                                                   20


<210>  8428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8428
gcucacugca agcucugccu                                                   20


<210>  8429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8429
cugcaagcuc ugccucccgg                                                   20


<210>  8430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8430
gccucccggg uucaugccau                                                   20


<210>  8431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8431
cggguucaug ccauucuccu                                                   20


<210>  8432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8432
ugccucagcc ucccgaguag                                                   20


<210>  8433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8433
gccucccgag uagcugggac                                                   20


<210>  8434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8434
cgaguagcug ggacuacagg                                                   20


<210>  8435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8435
ggaggcugag gcaggagaau                                                   20


<210>  8436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8436
aucuccugac cucgugaucc                                                   20


<210>  8437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8437
ugaccucgug auccacccgc                                                   20


<210>  8438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8438
ugauccaccc gccucggccu                                                   20


<210>  8439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8439
gccucccaaa gugcugggau                                                   20


<210>  8440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8440
caaagugcug ggauuacagg                                                   20


<210>  8441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8441
cgccuguaau cccagcacuu                                                   20


<210>  8442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8442
uagacuacag acuuguacag                                                   20


<210>  8443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8443
guguguagug ggcuacccca                                                   20


<210>  8444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8444
ggcucauagc ccuuucaccu                                                   20


<210>  8445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8445
uagcccuuuc accugcuggg                                                   20


<210>  8446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8446
agaaacacgc ugaaaucccc                                                   20


<210>  8447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8447
cuagaaacac gcugaaaucc                                                   20


<210>  8448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8448
ggcaccucag uccuuccacc                                                   20


<210>  8449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8449
guccuuccac cuccagagac                                                   20


<210>  8450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8450
agagaccuug ccugccccuu                                                   20


<210>  8451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8451
ggagguggaa ggacugaggu                                                   20


<210>  8452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8452
ugcccuuguc acuacgauaa                                                   20


<210>  8453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8453
uccagaaccu ccauuccaaa                                                   20


<210>  8454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8454
agaaccucca uuccaaacac                                                   20


<210>  8455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8455
auuccaaaca cgcccuuucu                                                   20


<210>  8456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8456
caacuccaau auuuucauug                                                   20


<210>  8457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8457
aauauuuuca uugacgccag                                                   20


<210>  8458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8458
cacucaccuc cuugcacauc                                                   20


<210>  8459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8459
cucaccuccu ugcacaucuc                                                   20


<210>  8460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8460
ccuccuugca caucuccccu                                                   20


<210>  8461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8461
uugcacaucu ccccuccucc                                                   20


<210>  8462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8462
ccuccuccca gcccagacuu                                                   20


<210>  8463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8463
ucccagccca gacuucaugg                                                   20


<210>  8464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8464
cagcccagac uucauggucc                                                   20


<210>  8465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8465
ccacauccuc guacuaguua                                                   20


<210>  8466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8466
uacuaguuau uguacucaca                                                   20


<210>  8467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8467
cagaggagaa aucccacucu                                                   20


<210>  8468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8468
gugaguacaa uaacuaguac                                                   20


<210>  8469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8469
ucugugagua caauaacuag                                                   20


<210>  8470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8470
acuuaaacuc agccaccccc                                                   20


<210>  8471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8471
gccaccccca acccccugcu                                                   20


<210>  8472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8472
ugcacccagg cggcugagca                                                   20


<210>  8473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8473
gccgccuggg ugcaggagca                                                   20


<210>  8474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8474
ggcugugcuc agccgccugg                                                   20


<210>  8475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8475
cuggcugugc ucagccgccu                                                   20


<210>  8476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8476
cucacaaacc acucggcucc                                                   20


<210>  8477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8477
caaaccacuc ggcuccugug                                                   20


<210>  8478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8478
gcuccugugg gcccuggagg                                                   20


<210>  8479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8479
ugugggcccu ggaggcgguc                                                   20


<210>  8480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8480
agggcccaca ggagccgagu                                                   20


<210>  8481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8481
guuuccaagu ccauuucucu                                                   20


<210>  8482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8482
gccugacuua uuuauuuuau                                                   20


<210>  8483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8483
guaaaagcgu auauaauagu                                                   20


<210>  8484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8484
gugagguaca uucuguaacu                                                   20


<210>  8485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8485
cagaguuguu uaaaaaauac                                                   20


<210>  8486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8486
ucgucuguga aauggcaaua                                                   20


<210>  8487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8487
uccugugugu cuaucucuuc                                                   20


<210>  8488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8488
aggacaaguc acgcagucuc                                                   20


<210>  8489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8489
uuucuccuua aacccccaaa                                                   20


<210>  8490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8490
uuaaaccccc aaauccuucu                                                   20


<210>  8491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8491
cccagccugc cuuauaguug                                                   20


<210>  8492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8492
uuggaauagg aagcaaggca                                                   20


<210>  8493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8493
auaaagagag aaccuccaau                                                   20


<210>  8494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8494
uuauugaguc uauuuucuca                                                   20


<210>  8495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8495
cuuuauugag ucuauuuucu                                                   20


<210>  8496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8496
aauggcuccc cccuccacau                                                   20


<210>  8497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8497
ccccuccaca ucaucucccu                                                   20


<210>  8498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8498
acaucaucuc ccuaccugcc                                                   20


<210>  8499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8499
cuaccugccu gccugugccu                                                   20


<210>  8500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8500
uuuuccaccu uccccuguga                                                   20


<210>  8501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8501
agacaagggu gcagccauaa                                                   20


<210>  8502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8502
auccucuaga caagggugca                                                   20


<210>  8503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8503
ccuccuaaga gaugcucccu                                                   20


<210>  8504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8504
uaagagaugc ucccuacucu                                                   20


<210>  8505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8505
uaggagguga gaagggaugg                                                   20


<210>  8506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8506
cuacucucca gcauugccag                                                   20


<210>  8507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8507
ccagcauugc cagcuucucu                                                   20


<210>  8508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8508
agcauugcca gcuucucugu                                                   20


<210>  8509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8509
gucucaacug uaacacuucc                                                   20


<210>  8510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8510
acuguaacac uuccaucagc                                                   20


<210>  8511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8511
gggccaucau ccaucuuccu                                                   20


<210>  8512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8512
ucuuccugca uugucucuac                                                   20


<210>  8513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8513
uccugcauug ucucuacaca                                                   20


<210>  8514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8514
acacaggccu uccuggugau                                                   20


<210>  8515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8515
acauggcuaa aucagaacac                                                   20


<210>  8516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8516
ccuugcuugu cccgugggcc                                                   20


<210>  8517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8517
uuugacccag uuggucacuu                                                   20


<210>  8518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8518
uccuggacau gcucccucgu                                                   20


<210>  8519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8519
uggacaugcu cccucgugau                                                   20


<210>  8520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8520
cucgugaucu cugugagucc                                                   20


<210>  8521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8521
ugaucucugu gaguccccug                                                   20


<210>  8522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8522
gugagucccc ugucauugaa                                                   20


<210>  8523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8523
cagagaucac gagggagcau                                                   20


<210>  8524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8524
ccuaaguucc augugacacc                                                   20


<210>  8525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8525
aacccaugca cccagaacuc                                                   20


<210>  8526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8526
ucaguucucc acuaagccac                                                   20


<210>  8527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8527
guucuccacu aagccacucc                                                   20


<210>  8528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8528
acuaagccac uccucucugg                                                   20


<210>  8529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8529
ucucugggcu ccccagcugc                                                   20


<210>  8530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8530
cugggcuccc cagcugcucc                                                   20


<210>  8531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8531
gggcucccca gcugcuccuu                                                   20


<210>  8532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8532
ccagcugcuc cuuaagugac                                                   20


<210>  8533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8533
uuaagugaca aggccaaaac                                                   20


<210>  8534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8534
cacaucucau cuguggacaa                                                   20


<210>  8535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8535
caucucaucu guggacaaau                                                   20


<210>  8536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8536
ucuguggaca aauacaaaua                                                   20


<210>  8537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8537
gagucccacu gcugccucug                                                   20


<210>  8538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8538
gaguguauuu guauuugucc                                                   20


<210>  8539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8539
gaucuaagcc acuaccagug                                                   20


<210>  8540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8540
cagucuccca ccugcucucu                                                   20


<210>  8541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8541
caccugcucu cucugcuuuu                                                   20


<210>  8542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8542
cucugcuuuu acccugguca                                                   20


<210>  8543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8543
cugcuuuuac ccuggucacc                                                   20


<210>  8544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8544
gcuuuuaccc uggucaccga                                                   20


<210>  8545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8545
cagcaauccu caaaaauuau                                                   20


<210>  8546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8546
aaaauuauaa aucagaucau                                                   20


<210>  8547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8547
gauaugguuu cgcugugucc                                                   20


<210>  8548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8548
gcuugaauug uauuucccag                                                   20


<210>  8549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8549
cacaacacgu gggaauucug                                                   20


<210>  8550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8550
cccugggucc cucccacaac                                                   20


<210>  8551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8551
ugguagugaa uaagucucag                                                   20


<210>  8552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8552
ggagaucuga uggguuuauc                                                   20


<210>  8553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8553
ugagacuuau ucacuaccau                                                   20


<210>  8554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8554
ucauuuucuc uugccuccgc                                                   20


<210>  8555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8555
uuuucucuug ccuccgccau                                                   20


<210>  8556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8556
ugccuccgcc auguaagaag                                                   20


<210>  8557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8557
gccauguaag aagugccuuu                                                   20


<210>  8558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8558
gaaucaugac gggaaacgaa                                                   20


<210>  8559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8559
gcagccacgu ggaacuauaa                                                   20


<210>  8560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8560
gguaugucuu uaucagcagc                                                   20


<210>  8561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8561
guaccaauuu acuggauuag                                                   20


<210>  8562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8562
caguaccaau uuacuggauu                                                   20


<210>  8563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8563
aaacuguucc aaauucugcc                                                   20


<210>  8564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8564
gaagaagaca ggaaaaugug                                                   20


<210>  8565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8565
cauuuuccug ucuucuucug                                                   20


<210>  8566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8566
aggaaguucc aaacuuucuc                                                   20


<210>  8567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8567
uagugauaug aacaauaagg                                                   20


<210>  8568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8568
ccuugggccu uauuguucau                                                   20


<210>  8569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8569
gagggggcag augaggaacu                                                   20


<210>  8570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8570
gagaccaccu caccuugggc                                                   20


<210>  8571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8571
ucugcccccu cugagaccac                                                   20


<210>  8572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8572
aguucccaac aaguuccuca                                                   20


<210>  8573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8573
uguuauguuu uagcaaagag                                                   20


<210>  8574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8574
uugcuaaaac auaacaggag                                                   20


<210>  8575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8575
agggcagggg caaaauguug                                                   20


<210>  8576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8576
aguucgacgu uccgcaaauc                                                   20


<210>  8577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8577
caaguucgac guuccgcaaa                                                   20


<210>  8578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8578
cucaaguucg acguuccgca                                                   20


<210>  8579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8579
ugaaugcuuu gcugcuuaga                                                   20


<210>  8580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8580
gcuucccguu caaaacagaa                                                   20


<210>  8581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8581
aaaaaugggu uuuucuuuuc                                                   20


<210>  8582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8582
ucaaaaaaug gguuuuucuu                                                   20


<210>  8583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8583
uugcuacuua ggcaaauuuc                                                   20


<210>  8584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8584
aaaccaugga gaaaaugucu                                                   20


<210>  8585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8585
augguuuuga ggauuaacac                                                   20


<210>  8586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8586
aggccauguc agggaccuuc                                                   20


<210>  8587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8587
ucccaucaca ggccuagagc                                                   20


<210>  8588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8588
caucacaggc cuagagcccc                                                   20


<210>  8589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8589
aggccuguga ugggaggagc                                                   20


<210>  8590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8590
uggggcucua ggccugugau                                                   20


<210>  8591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8591
gugucccagc ugcuccaggc                                                   20


<210>  8592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8592
aggcauggcu gaaagggguc                                                   20


<210>  8593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8593
gaagccacag cccaagcugu                                                   20


<210>  8594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8594
acaccacaua gaaguugcca                                                   20


<210>  8595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8595
auucuugacu ucugugcacc                                                   20


<210>  8596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8596
accuagauuu cagaagacgu                                                   20


<210>  8597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8597
uggagaaccu cugguaggac                                                   20


<210>  8598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8598
augagcaccc cacccugaag                                                   20


<210>  8599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8599
gguaggacag ugcagaaggg                                                   20


<210>  8600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8600
acuaggcaau gccccaguag                                                   20


<210>  8601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8601
gcuccacuag gcaaugcccc                                                   20


<210>  8602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8602
acucagcucc acuaggcaau                                                   20


<210>  8603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8603
agaccccaga augguagauc                                                   20


<210>  8604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8604
uggaaaaucu gcagacaauc                                                   20


<210>  8605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8605
caacagcuuu caugggcugg                                                   20


<210>  8606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8606
cucccaacag cuuucauggg                                                   20


<210>  8607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8607
gccccuguga cuuugcaggg                                                   20


<210>  8608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8608
ugcaucagcg ugaccuggau                                                   20


<210>  8609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8609
cauccagguc acgcugaugc                                                   20


<210>  8610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8610
acaucucaca uccaggucac                                                   20


<210>  8611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8611
uuugacucca caucucacau                                                   20


<210>  8612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8612
aaaaugaucu ccuuugacuc                                                   20


<210>  8613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8613
cauuuggaau ggcuguauuu                                                   20


<210>  8614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8614
uagguggaag ggacuugccu                                                   20


<210>  8615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8615
gaugagacuu uggacugugg                                                   20


<210>  8616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8616
ucugagacaa ggcaaguccc                                                   20


<210>  8617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8617
uuucagcauu gacccaaaag                                                   20


<210>  8618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8618
aaguuuuaac ucauuucagc                                                   20


<210>  8619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8619
caaaguuuua acucauuuca                                                   20


<210>  8620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8620
cauuucaaaa ccaaucaugc                                                   20


<210>  8621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8621
aaauuucaug uccucacauu                                                   20


<210>  8622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8622
cagcuugaau ugugucuccc                                                   20


<210>  8623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8623
cagaauuccc acauguugug                                                   20


<210>  8624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8624
cacaacaugu gggaauucug                                                   20


<210>  8625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8625
cucccacaac augugggaau                                                   20


<210>  8626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8626
cuggcucccu cccacaacau                                                   20


<210>  8627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8627
cccuggcucc cucccacaac                                                   20


<210>  8628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8628
ugauagugaa uaagucucau                                                   20


<210>  8629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8629
uaggaucuga ugggauuauc                                                   20


<210>  8630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8630
ugcuguugcc auguaagaag                                                   20


<210>  8631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8631
ugccgugauu cugaggccug                                                   20


<210>  8632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8632
gaaucacggc aggaggcgaa                                                   20


<210>  8633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8633
uuuucuuccc agucuugggu                                                   20


<210>  8634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8634
ucugcuuaaa accugcccuu                                                   20


<210>  8635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8635
gcuuaaaacc ugcccuuagc                                                   20


<210>  8636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8636
ccaccuuccc ggagaaaagc                                                   20


<210>  8637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8637
accuucccgg agaaaagcca                                                   20


<210>  8638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8638
gggaaggugg agagcuaagg                                                   20


<210>  8639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8639
ggcuuuucuc cgggaaggug                                                   20


<210>  8640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8640
ccaaccauuc uggggacucu                                                   20


<210>  8641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8641
cccaggucug cccccacacc                                                   20


<210>  8642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8642
agcccagcuc uuccuugcag                                                   20


<210>  8643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8643
uccuugcagg cuccuuccca                                                   20


<210>  8644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8644
uucccaucuc ugggcuguuc                                                   20


<210>  8645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8645
gggcuguucc agucuggggc                                                   20


<210>  8646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8646
acugugucca cggcccgucc                                                   20


<210>  8647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8647
cagcuccuuu ccuccagugu                                                   20


<210>  8648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8648
gcuccuuucc uccaguguuc                                                   20


<210>  8649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8649
uuuccuccag uguucucuuu                                                   20


<210>  8650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8650
aguguucucu uugcacaccg                                                   20


<210>  8651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8651
uugcacaccg cccuguuuua                                                   20


<210>  8652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8652
cacccucuuc ucuuuuccuu                                                   20


<210>  8653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8653
ucucuuuucc uuuuccucca                                                   20


<210>  8654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8654
uuuccuuuuc cuccauggca                                                   20


<210>  8655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8655
auggcacuca ucaccaucuc                                                   20


<210>  8656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8656
ucaccaucuc acacaguaca                                                   20


<210>  8657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8657
cacaguacau guuugauuug                                                   20


<210>  8658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8658
aguagggcgg aacagacgac                                                   20


<210>  8659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8659
cucuaguagg gcggaacaga                                                   20


<210>  8660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8660
gucauuaaac auacauguca                                                   20


<210>  8661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8661
agcuuggugc uagggaugcc                                                   20


<210>  8662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8662
ggcagguucc cugcuuauac                                                   20


<210>  8663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8663
guauaagcag ggaaccugcc                                                   20


<210>  8664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8664
cugacagguu ugcaggcagc                                                   20


<210>  8665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8665
gacagguuug caggcagccc                                                   20


<210>  8666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8666
caugugcagu aggggcuaca                                                   20


<210>  8667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8667
caaguagaga guugcagccc                                                   20


<210>  8668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8668
aguagagagu ugcagcccug                                                   20


<210>  8669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8669
acuugagagc auuuccuccc                                                   20


<210>  8670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8670
cuacuugaga gcauuuccuc                                                   20


<210>  8671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8671
ccgaccucag gagggagagc                                                   20


<210>  8672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8672
ggagggagag cccugagcuc                                                   20


<210>  8673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8673
ugaggucggg gagacagggc                                                   20


<210>  8674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8674
cuccugaggu cggggagaca                                                   20


<210>  8675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8675
cccuccugag gucggggaga                                                   20


<210>  8676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8676
gggcucuccc uccugagguc                                                   20


<210>  8677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8677
aacccuugcc cucuggggcu                                                   20


<210>  8678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8678
ggggcuaugg gaaacagcug                                                   20


<210>  8679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8679
cuuuccagcu guuucccaua                                                   20


<210>  8680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8680
gacccauagc ugugugaugu                                                   20


<210>  8681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8681
cccucucugc cucucaauuu                                                   20


<210>  8682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8682
cucucugccu cucaauuuuc                                                   20


<210>  8683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8683
cugccucuca auuuucuugu                                                   20


<210>  8684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8684
gccucucaau uuucuugucu                                                   20


<210>  8685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8685
caauuuucuu gucuauuaaa                                                   20


<210>  8686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8686
auuuucuugu cuauuaaaca                                                   20


<210>  8687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8687
guuuaauaga caagaaaauu                                                   20


<210>  8688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8688
uucgccccag cccuguggga                                                   20


<210>  8689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8689
uuguccacaa agcauuuuca                                                   20


<210>  8690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8690
ucuuugucca caaagcauuu                                                   20


<210>  8691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8691
uccucuuugu ccacaaagca                                                   20


<210>  8692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8692
aagagaggag ccauguuuau                                                   20


<210>  8693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8693
uggagcacuu agaacuccuc                                                   20


<210>  8694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8694
cuuggagcac uuagaacucc                                                   20


<210>  8695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8695
ucucuuggag cacuuagaac                                                   20


<210>  8696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8696
gaaaaacccc aaaagacaua                                                   20


<210>  8697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8697
accucagaaa aaccccaaaa                                                   20


<210>  8698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8698
cucuguugcc cagcugaagu                                                   20


<210>  8699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8699
guugcccagc ugaagugcag                                                   20


<210>  8700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8700
gcucaccgca accucugccu                                                   20


<210>  8701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8701
ccgcaaccuc ugccucccgg                                                   20


<210>  8702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8702
gccucccggg uucaagcaau                                                   20


<210>  8703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8703
cggguucaag caauuccccu                                                   20


<210>  8704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8704
cuaguagcug ggauuacagg                                                   20


<210>  8705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8705
acuaaaauac aaaaauuagc                                                   20


<210>  8706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8706
aacuccugac cucaauugau                                                   20


<210>  8707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8707
ugaccucaau ugauccgucu                                                   20


<210>  8708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8708
auugauccgu cugccucgga                                                   20


<210>  8709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8709
gacucccaaa augcugggau                                                   20


<210>  8710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8710
caaaaugcug ggauuacagg                                                   20


<210>  8711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8711
cgccuguaau cccagcauuu                                                   20


<210>  8712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8712
cuuauaauuc cauuuggggu                                                   20


<210>  8713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8713
uauaauucca uuuggggucu                                                   20


<210>  8714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8714
gcauaaacaa cauaagauuu                                                   20


<210>  8715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8715
auuuauuucu uuuuaccagc                                                   20


<210>  8716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8716
auugaugaau guuuggauug                                                   20


<210>  8717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8717
uauugaauuu cuuccagggg                                                   20


<210>  8718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8718
cuuugaucug ccaggguguc                                                   20


<210>  8719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8719
cacuuugauc ugccagggug                                                   20


<210>  8720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8720
aauaaaacuc ucacuuugau                                                   20


<210>  8721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8721
ucuaauaaaa cucucacuuu                                                   20


<210>  8722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8722
accagcuuua cugucuccuc                                                   20


<210>  8723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8723
ccgcuccacc agcuuuacug                                                   20


<210>  8724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8724
ccccgcucca ccagcuuuac                                                   20


<210>  8725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8725
gacugcaaca uguugauuca                                                   20


<210>  8726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8726
uaccacccca agaggcagga                                                   20


<210>  8727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8727
ugggguggua ugaguccugg                                                   20


<210>  8728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8728
ugccucuugg ggugguauga                                                   20


<210>  8729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8729
gugcccuucu ggcugcgcug                                                   20


<210>  8730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8730
ucagugcccu ucuggcugcg                                                   20


<210>  8731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8731
cuguggcucc cagcagcggg                                                   20


<210>  8732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8732
cagcagcggg accagaugca                                                   20


<210>  8733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8733
guaaagacug aacaggguau                                                   20


<210>  8734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8734
uaaaacagcu ucugacucag                                                   20


<210>  8735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8735
gcucuuaaaa cagcuucuga                                                   20


<210>  8736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8736
gcuguaaaau gggugugcuc                                                   20


<210>  8737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8737
agccucaucc uugaauggug                                                   20


<210>  8738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8738
uccuugaaug guggguguac                                                   20


<210>  8739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8739
acacacuuua guugcucucc                                                   20


<210>  8740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8740
ccguuugcac aaugauuucu                                                   20


<210>  8741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8741
guuugcacaa ugauuucuau                                                   20


<210>  8742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8742
uuguccacuu gccuaauuau                                                   20


<210>  8743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8743
agucaguagc aaacugugaa                                                   20


<210>  8744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8744
acaucuaauu cuggcuguuu                                                   20


<210>  8745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8745
cuugcgacuc uacaucuaau                                                   20


<210>  8746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8746
cugauuagaa augacgucuu                                                   20


<210>  8747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8747
uuuuuucucc cugauuagaa                                                   20


<210>  8748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8748
agaaggcuag ccuauuguuc                                                   20


<210>  8749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8749
cuccuuauac aaaaguaaau                                                   20


<210>  8750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8750
uuauacaaaa guaaauccca                                                   20


<210>  8751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8751
uuuuuuaaau cuuuuuuuaa                                                   20


<210>  8752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8752
uuaucaagau cauauaaaaa                                                   20


<210>  8753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8753
uccuuaucaa gaucauauaa                                                   20


<210>  8754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8754
augaaaauua aaauuuucua                                                   20


<210>  8755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8755
uauguauguu gcaaaucuau                                                   20


<210>  8756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8756
acagccaaaa ugaaaaaaug                                                   20


<210>  8757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8757
ucauuuuuuc auuuuggcug                                                   20


<210>  8758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8758
guguuggccu gggugugacc                                                   20


<210>  8759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8759
uggucacacc caggccaaca                                                   20


<210>  8760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8760
uccuucuggg cacuuggugu                                                   20


<210>  8761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8761
uucugggcac uuggugugau                                                   20


<210>  8762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8762
cuuaggagaa ggaaauguga                                                   20


<210>  8763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8763
uaagcgagac acaugaccac                                                   20


<210>  8764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8764
augcagcuuc cacacaaaag                                                   20


<210>  8765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8765
uugcuuuccg ucagccucag                                                   20


<210>  8766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8766
guguucagca auguucugaa                                                   20


<210>  8767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8767
ccccagaacc agacugauaa                                                   20


<210>  8768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8768
cauguccauc aaggacuuug                                                   20


<210>  8769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8769
ccucacaugu ccaucaagga                                                   20


<210>  8770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8770
ggggcuugaa augucaaagg                                                   20


<210>  8771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8771
agcacugcuc gugggaagac                                                   20


<210>  8772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8772
ugggaagaca ucaucaauau                                                   20


<210>  8773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8773
auauugauga ugucuuccca                                                   20


<210>  8774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8774
aaauuccacu uccaggaauu                                                   20


<210>  8775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8775
cacaugugca aacagcuaug                                                   20


<210>  8776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8776
caugugcaaa cagcuaugga                                                   20


<210>  8777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8777
gaauaaaaac cacacuggua                                                   20


<210>  8778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8778
ccaccccacc aauauaaaua                                                   20


<210>  8779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8779
accccaccaa uauaaauaaa                                                   20


<210>  8780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8780
uuaacccacu uuuuaaaauu                                                   20


<210>  8781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8781
gaaaagauac ccaauaaaua                                                   20


<210>  8782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8782
ugcaguuaug gaagccagaa                                                   20


<210>  8783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8783
cccaaagcuc uaggggagga                                                   20


<210>  8784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8784
caaagcucua ggggaggaac                                                   20


<210>  8785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8785
aggggaggaa cauuccuugc                                                   20


<210>  8786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8786
ccuagagcuu ugggagaggg                                                   20


<210>  8787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8787
uuugggggcu ccuggcauuc                                                   20


<210>  8788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8788
uggcauuccu uggcuuaugu                                                   20


<210>  8789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8789
aaucggcgcc uccauuguua                                                   20


<210>  8790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8790
auuguuacau agguguuucu                                                   20


<210>  8791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8791
aguaucucuc cccuuucucu                                                   20


<210>  8792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8792
ccccuuucuc uucugauauc                                                   20


<210>  8793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8793
ccuuucucuu cugauaucag                                                   20


<210>  8794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8794
ucugauauca gucauuggau                                                   20


<210>  8795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8795
ucaugagauc cuuaggucaa                                                   20


<210>  8796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8796
ugagauccuu aggucaauua                                                   20


<210>  8797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8797
ugaggagauu auccuggguu                                                   20


<210>  8798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8798
uuuccaaaua aggucacauu                                                   20


<210>  8799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8799
gaagguggug guucaggagu                                                   20


<210>  8800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8800
ugaaccacca ccuucugagg                                                   20


<210>  8801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8801
cacuccugaa ccaccaccuu                                                   20


<210>  8802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8802
cuugcaaaaa agaguaugcc                                                   20


<210>  8803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8803
uuuuugcaag ggagggggca                                                   20


<210>  8804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8804
cagcaauggu ggcugcagac                                                   20


<210>  8805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8805
aaguuucuga gguuggagaa                                                   20


<210>  8806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8806
gaaacuugga gucugcagcc                                                   20


<210>  8807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8807
aaccucagaa acuuggaguc                                                   20


<210>  8808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8808
cuggcuaccu ucuccaaccu                                                   20


<210>  8809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8809
cuuuuaugcu cccuggcuac                                                   20


<210>  8810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8810
uucagucuau gaggggaagg                                                   20


<210>  8811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8811
uagacugaau gaguagauag                                                   20


<210>  8812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8812
aaaugcuuuu cuagccauug                                                   20


<210>  8813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8813
aaaaaugcca cuuuuacugu                                                   20


<210>  8814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8814
cucuaaaaau gccacuuuua                                                   20


<210>  8815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8815
aggcuuccuc ccucuaaaaa                                                   20


<210>  8816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8816
ggaagaggca uuuagggaua                                                   20


<210>  8817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8817
uccugaguua uucuuucccu                                                   20


<210>  8818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8818
uaucccuaaa ugccucuucc                                                   20


<210>  8819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8819
ucuuaucccu aaaugccucu                                                   20


<210>  8820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8820
uccucuuauc ccuaaaugcc                                                   20


<210>  8821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8821
ccuccucuua ucccuaaaug                                                   20


<210>  8822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8822
ucuccuccuc uuaucccuaa                                                   20


<210>  8823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8823
acuaucuccu cuccuccucu                                                   20


<210>  8824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8824
gcagggauca ccuaccucca                                                   20


<210>  8825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8825
ccugccccaa ucuggccucc                                                   20


<210>  8826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8826
gcugacacuc cccugcccca                                                   20


<210>  8827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8827
uauacucagc ugacacuccc                                                   20


<210>  8828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8828
gcccugaagg aggaaggcag                                                   20


<210>  8829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8829
uucagggcag aggggaccau                                                   20


<210>  8830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8830
ugccuuccuc cuucagggca                                                   20


<210>  8831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8831
accacaagug cuuucugggu                                                   20


<210>  8832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8832
ccuccaccac aagugcuuuc                                                   20


<210>  8833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8833
ucuggggccu ccccuccacc                                                   20


<210>  8834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8834
caggggagcu ggcugcuuau                                                   20


<210>  8835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8835
ggggagcugg cugcuuauuu                                                   20


<210>  8836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8836
ccugagaggu accagcaauc                                                   20


<210>  8837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8837
aauggguucc cccacacccu                                                   20


<210>  8838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8838
ucucaaaugg guucccccac                                                   20


<210>  8839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8839
cucuucucaa auggguuccc                                                   20


<210>  8840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8840
cauaaguugc ccaaaggaau                                                   20


<210>  8841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8841
ccaauuaccc cucccauaag                                                   20


<210>  8842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8842
ugccacuugg cagggcuuuc                                                   20


<210>  8843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8843
uaagagugca guggaggaua                                                   20


<210>  8844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8844
uaugaggggc agccccagcu                                                   20


<210>  8845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8845
acugcacucu uaugaggggc                                                   20


<210>  8846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8846
ucccauaucc uccacugcac                                                   20


<210>  8847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8847
gguuccaucu gucgcagagc                                                   20


<210>  8848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8848
gcgacagaug gaaccagagg                                                   20


<210>  8849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8849
cccaccuccc ucagaacaca                                                   20


<210>  8850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8850
cucagaacac acccacugca                                                   20


<210>  8851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8851
gaacacaccc acugcaugcu                                                   20


<210>  8852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8852
gugcacaggc uucaucauuc                                                   20


<210>  8853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8853
gggugcacgg uaacgacccc                                                   20


<210>  8854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8854
ccuaccgggg ucguuaccgu                                                   20


<210>  8855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8855
caccuaccgg ggucguuacc                                                   20


<210>  8856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8856
ccuuugggac cuuggccucu                                                   20


<210>  8857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8857
caucuauucu ugcuccaggg                                                   20


<210>  8858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8858
aggggaggcc uuugaugagg                                                   20


<210>  8859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8859
ccuggagcaa gaauagaugg                                                   20


<210>  8860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8860
ucaaaggccu ccccuggagc                                                   20


<210>  8861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8861
uuccuguugc cuguaauugg                                                   20


<210>  8862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8862
gccaccucug ucagcaaacc                                                   20


<210>  8863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8863
gucagcaaac caugagcucc                                                   20


<210>  8864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8864
ugguuugcug acagaggugg                                                   20


<210>  8865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8865
uacucugugc ugcgauggcg                                                   20


<210>  8866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8866
gugcugcgau ggcgggcucg                                                   20


<210>  8867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8867
auggggauaa cucugaccuu                                                   20


<210>  8868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8868
gaccuuaccu cauggaguca                                                   20


<210>  8869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8869
uggagucacu gucaacccac                                                   20


<210>  8870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8870
augagguaag gucagaguua                                                   20


<210>  8871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8871
cuggagugag gucuuugcaa                                                   20


<210>  8872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8872
ggagugaggu cuuugcaaac                                                   20


<210>  8873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8873
agagagccag ugcacaaaga                                                   20


<210>  8874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8874
cuccagagag ccagugcaca                                                   20


<210>  8875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8875
uuccacuuug uuugcaaaga                                                   20


<210>  8876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8876
agcaccuaga uucagagcag                                                   20


<210>  8877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8877
gaaucuaggu gcuggagucc                                                   20


<210>  8878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8878
gaaucugcug ugcaucugca                                                   20


<210>  8879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8879
cuugcagaug cacagcagau                                                   20


<210>  8880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8880
uucuggaagg gcugucgaua                                                   20


<210>  8881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8881
ugucaugcca cauguacaau                                                   20


<210>  8882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8882
gauuguacau guggcaugac                                                   20


<210>  8883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8883
uggccucaga uuguacaugu                                                   20


<210>  8884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8884
cuuuccccuu uucauccucc                                                   20


<210>  8885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8885
uuccccuuuu cauccuccug                                                   20


<210>  8886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8886
ugccugguac acaauaggug                                                   20


<210>  8887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8887
gcuuuccaga agauucaauu                                                   20


<210>  8888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8888
ucaaggagca gcuaguuggu                                                   20


<210>  8889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8889
uugaagagau ugcuugcuuu                                                   20


<210>  8890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8890
gcccuuuaug cacccugcac                                                   20


<210>  8891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8891
ggccucugcc cuuuaugcac                                                   20


<210>  8892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8892
cugcccaccg aauucuuucc                                                   20


<210>  8893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8893
ucgcugccca ccgaauucuu                                                   20


<210>  8894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8894
cuggucagca ggagacaagg                                                   20


<210>  8895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8895
ugcugaccag ugagacuucu                                                   20


<210>  8896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8896
aaguucugcc gggcccaccu                                                   20


<210>  8897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8897
cccugcgugg gaugccagac                                                   20


<210>  8898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8898
cacccugcgu gggaugccag                                                   20


<210>  8899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8899
cgccucucac ccugcguggg                                                   20


<210>  8900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8900
cccgccucuc acccugcgug                                                   20


<210>  8901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8901
ucucccgccu cucacccugc                                                   20


<210>  8902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8902
uccucucccg ccucucaccc                                                   20


<210>  8903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8903
caaauccuaa cugggcugga                                                   20


<210>  8904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8904
gcgcguaauc ugacgcuguu                                                   20


<210>  8905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8905
ccaaacagcg ucagauuacg                                                   20


<210>  8906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8906
cccuccccaa acagcgucag                                                   20


<210>  8907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8907
aguccggggg uuccguuaau                                                   20


<210>  8908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8908
gguggcguga ucugcgcgcc                                                   20


<210>  8909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8909
acgucgcugc ggaaaccuuc                                                   20


<210>  8910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8910
ugguugcagg cgggcgccgc                                                   20


<210>  8911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8911
gacccugaac ugaacggcgg                                                   20


<210>  8912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8912
aggcucagac ccugaacuga                                                   20


<210>  8913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8913
uccaggcuca gacccugaac                                                   20


<210>  8914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8914
cuccuccagg cucagacccu                                                   20


<210>  8915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8915
cugccuggcu cacuccucca                                                   20


<210>  8916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8916
ggcgggccgg gacgcgucgu                                                   20


<210>  8917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8917
cagcucccag ccaggauucc                                                   20


<210>  8918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8918
cagccaggau uccgcgcgcc                                                   20


<210>  8919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8919
ugaacuucag cuccugcaca                                                   20


<210>  8920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8920
ugcacagucc uccccaccgc                                                   20


<210>  8921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8921
ccaccgcaag gcucaaggcg                                                   20


<210>  8922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8922
aggcgccgcc ggcguggacc                                                   20


<210>  8923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8923
aggucuccuc gccaggacag                                                   20


<210>  8924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8924
ucgccaggac agcaaccucu                                                   20


<210>  8925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8925
ccaggacagc aaccucuccc                                                   20


<210>  8926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8926
ccccuggccc ucaugggcac                                                   20


<210>  8927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8927
ccuggcccuc augggcaccg                                                   20


<210>  8928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8928
ugggcaccgu cagcuccagg                                                   20


<210>  8929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8929
aggcgguccu gguggccgcu                                                   20


<210>  8930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8930
ugggucccgc gggcgcccgu                                                   20


<210>  8931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8931
ugcgcacggg cgcccgcggg                                                   20


<210>  8932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8932
uccuccugcg cacgggcgcc                                                   20


<210>  8933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8933
uagucgccgu ccucguccuc                                                   20


<210>  8934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8934
ucguagucgc cguccucguc                                                   20


<210>  8935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8935
gaacgcaagg cuagcaccag                                                   20


<210>  8936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8936
ucggaacgca aggcuagcac                                                   20


<210>  8937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8937
ggugcuucgg ccaggccguc                                                   20


<210>  8938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8938
caucccuaca cccgcaccuu                                                   20


<210>  8939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8939
cgggccucag uuucccccca                                                   20


<210>  8940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8940
ggccucaguu uccccccaug                                                   20


<210>  8941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8941
guuucccccc auguaagaga                                                   20


<210>  8942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8942
uacauggggg gaaacugagg                                                   20


<210>  8943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8943
cuuacauggg gggaaacuga                                                   20


<210>  8944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8944
acuuccucuc uuacaugggg                                                   20


<210>  8945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8945
gcgaccugca cuccacuucc                                                   20


<210>  8946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8946
ucgcuuggca cgaucuuggg                                                   20


<210>  8947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8947
cccgccgccu ugccugcagu                                                   20


<210>  8948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8948
ccacuacccg uccucccccg                                                   20


<210>  8949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8949
accgugcucc ccacuacccg                                                   20


<210>  8950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8950
ccaccgugcu ccccacuacc                                                   20


<210>  8951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8951
uuggggacuu gcuggggcgu                                                   20


<210>  8952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8952
caaccccgcg aaccuuccca                                                   20


<210>  8953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8953
gggucuccca accccgcgaa                                                   20


<210>  8954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8954
gccuccgggu cucccaaccc                                                   20


<210>  8955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8955
cccuuccucg gccuccgggu                                                   20


<210>  8956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8956
gcucgcccuu ccucggccuc                                                   20


<210>  8957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8957
ccgcggcaca ggugggugaa                                                   20


<210>  8958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8958
uucacccacc ugugccgcgg                                                   20


<210>  8959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8959
gugccuggug caguucccag                                                   20


<210>  8960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8960
gcugcccaug uuuuccaaac                                                   20


<210>  8961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8961
acccuccgcu gcccauguuu                                                   20


<210>  8962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8962
aggcccucca cccuccgcug                                                   20


<210>  8963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8963
ccaggcccuc cacccuccgc                                                   20


<210>  8964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8964
gguagggccu ucucuccagg                                                   20


<210>  8965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8965
cagcaucugc cguccuuccc                                                   20


<210>  8966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8966
ugcucccagc aucugccguc                                                   20


<210>  8967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8967
ugcucuagua uuccaucugu                                                   20


<210>  8968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8968
aguauuccau cuguuucagc                                                   20


<210>  8969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8969
ccugccccuu cagcugguuc                                                   20


<210>  8970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8970
gccccuucuc cccugccccu                                                   20


<210>  8971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8971
aggcccauug gcguccuuua                                                   20


<210>  8972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8972
agaauaccuc cgccccuucu                                                   20


<210>  8973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8973
ggcagggaag ggcccuuggu                                                   20


<210>  8974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8974
ggagccggag guggugcgcc                                                   20


<210>  8975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8975
agagcaccaa gggcccuucc                                                   20


<210>  8976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8976
ggcuccagag caccaagggc                                                   20


<210>  8977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8977
ggggucccag uaccaggcgc                                                   20


<210>  8978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8978
gcuccggggu cccaguacca                                                   20


<210>  8979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8979
gcccaccugg cugucugccg                                                   20


<210>  8980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8980
ccccgcacac ggucggcaga                                                   20


<210>  8981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8981
acaacucugc cagcuucugg                                                   20


<210>  8982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8982
gccagcuucu ggcccucagg                                                   20


<210>  8983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8983
ggcuguggga agcuucuucc                                                   20


<210>  8984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8984
ccccgggaag aagcuuccca                                                   20


<210>  8985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8985
gccaaguccu gggcugguaa                                                   20


<210>  8986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8986
aagcuggggg acacagaacc                                                   20


<210>  8987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8987
cacuagcugu ggugcuugac                                                   20


<210>  8988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8988
cuagcugugg ugcuugacaa                                                   20


<210>  8989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8989
aggauaagug acuugucaag                                                   20


<210>  8990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8990
auugccuaau cuuuaaaagg                                                   20


<210>  8991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8991
cuuuuaaaga uuaggcaaug                                                   20


<210>  8992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8992
guggcagcag auggggagau                                                   20


<210>  8993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8993
ccaucugcug ccacugagcc                                                   20


<210>  8994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8994
uggucaacag aacuuucccu                                                   20


<210>  8995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8995
aaaccacagc uccuggggca                                                   20


<210>  8996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8996
uggggcagag gggaaaauuc                                                   20


<210>  8997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8997
gccccaggag cugugguuug                                                   20


<210>  8998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8998
cagcugccug cccacgcuuc                                                   20


<210>  8999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  8999
gacagaagcg ugggcaggca                                                   20


<210>  9000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9000
gcucaguaua gcccucuucc                                                   20


<210>  9001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9001
guauagcccu cuuccuuguu                                                   20


<210>  9002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9002
uccuuguucc cugagccuuu                                                   20


<210>  9003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9003
gggaacaagg aagagggcua                                                   20


<210>  9004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9004
agggauguug ugggguugug                                                   20


<210>  9005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9005
agaaagucaa aggcucaggg                                                   20


<210>  9006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9006
aaaacaacug uucuggaaau                                                   20


<210>  9007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9007
cuauuuccag aacaguuguu                                                   20


<210>  9008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9008
ggauggggua cucacuauuu                                                   20


<210>  9009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9009
caggaugggg uacucacuau                                                   20


<210>  9010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9010
ccucucagga ugggguacuc                                                   20


<210>  9011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9011
gcuuacucac cucucaggau                                                   20


<210>  9012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9012
agggcuuggu ucaggugguc                                                   20


<210>  9013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9013
gguggaaguu uggaacagga                                                   20


<210>  9014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9014
uguuccaaac uuccaccaga                                                   20


<210>  9015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9015
ucaaguucau uuauucauuc                                                   20


<210>  9016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9016
aguucauuua uucauucauu                                                   20


<210>  9017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9017
ugacuaaaag aaaaggauug                                                   20


<210>  9018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9018
guuucucaug acuaaaagaa                                                   20


<210>  9019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9019
gggccucagu uucucaugac                                                   20


<210>  9020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9020
cugggccuca guuucucaug                                                   20


<210>  9021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9021
cucugggccu caguuucuca                                                   20


<210>  9022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9022
ucucucuggg ccucaguuuc                                                   20


<210>  9023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9023
acugcacaga guacucuccc                                                   20


<210>  9024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9024
gugcagugga gugucaguuc                                                   20


<210>  9025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9025
cccaauucau ucaauuuuua                                                   20


<210>  9026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9026
caauucauuc aauuuuuauu                                                   20


<210>  9027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9027
uacuaaugcu ucaaagaccc                                                   20


<210>  9028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9028
ugacaccauc aucgcugaac                                                   20


<210>  9029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9029
uaauccuaga auaaaauucu                                                   20


<210>  9030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9030
guaucuuugu ucaugguacc                                                   20


<210>  9031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9031
gguuuuccca gcucuguauc                                                   20


<210>  9032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9032
uuaucuucca ccucugguuu                                                   20


<210>  9033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9033
aaaaaaaaag aaaaagaacu                                                   20


<210>  9034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9034
aucucaaaaa aaaaagaaaa                                                   20


<210>  9035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9035
uguugcccag gcuggagugc                                                   20


<210>  9036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9036
agccugggca acaagagcga                                                   20


<210>  9037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9037
gcucacugca acaucugucu                                                   20


<210>  9038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9038
cugcaacauc ugucucccgg                                                   20


<210>  9039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9039
cggguucaag ugguucuccu                                                   20


<210>  9040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9040
ugccucagcc ucccaagaag                                                   20


<210>  9041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9041
gccucccaag aagcugggau                                                   20


<210>  9042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9042
caagaagcug ggauuacagg                                                   20


<210>  9043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9043
acuaaaaaua caaaaauuag                                                   20


<210>  9044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9044
ugaccuccuc aguggauccg                                                   20


<210>  9045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9045
ucaguggauc cgaggaggug                                                   20


<210>  9046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9046
guggauccga ggaggugauc                                                   20


<210>  9047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9047
gauccacuga ggaggucagg                                                   20


<210>  9048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9048
ucggauccac ugaggagguc                                                   20


<210>  9049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9049
cgccucagcc ucccaaagug                                                   20


<210>  9050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9050
gccucccaaa gugcucgaau                                                   20


<210>  9051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9051
caaagugcuc gaauuacagg                                                   20


<210>  9052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9052
aauuacaggu gugagccacc                                                   20


<210>  9053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9053
caccuguaau ucgagcacuu                                                   20


<210>  9054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9054
acaguucuuu auccaccguc                                                   20


<210>  9055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9055
ugucaguuca cgucaggugc                                                   20


<210>  9056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9056
agauucuucc aagcagacuc                                                   20


<210>  9057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9057
gauugcccau uacugccuuu                                                   20


<210>  9058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9058
gaacuuguuu ggauuuuaga                                                   20


<210>  9059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9059
guucuacucu gacuggaguc                                                   20


<210>  9060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9060
gacuggaguc caagaugcau                                                   20


<210>  9061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9061
agucagagua gaacagaguc                                                   20


<210>  9062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9062
guauauaugc aucuuggacu                                                   20


<210>  9063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9063
accuaccuug cagccccauc                                                   20


<210>  9064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9064
uuggccccua ccucaaccua                                                   20


<210>  9065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9065
uccuuggccc cuaccucaac                                                   20


<210>  9066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9066
augcuccucc uuggccccua                                                   20


<210>  9067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9067
ugaaucaagu ccaaacucca                                                   20


<210>  9068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9068
ccacagccuc augaaucaag                                                   20


<210>  9069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9069
ggcagacaua ccugcuuaag                                                   20


<210>  9070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9070
caggcagaca uaccugcuua                                                   20


<210>  9071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9071
aacugcucuc aggcagacau                                                   20


<210>  9072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9072
ugucugcucc aacugcucuc                                                   20


<210>  9073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9073
aaaucucaug uggaaauuug                                                   20


<210>  9074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9074
uguggaaauu ugguccucag                                                   20


<210>  9075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9075
guguuggaag uggggccuaa                                                   20


<210>  9076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9076
cauuaggccc cacuuccaac                                                   20


<210>  9077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9077
cccaugaccc aaacaccucc                                                   20


<210>  9078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9078
uuaucacaag gacggcacca                                                   20


<210>  9079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9079
cgcuaugauu ucccuugaag                                                   20


<210>  9080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9080
uuuuaauaau cagccuucaa                                                   20


<210>  9081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9081
cucucuucuc ucuugcuucu                                                   20


<210>  9082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9082
cuucucucuu gcuucuucuc                                                   20


<210>  9083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9083
ucucucuugc uucuucucuu                                                   20


<210>  9084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9084
cuugcuucuu cucuugccau                                                   20


<210>  9085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9085
ugcuucuucu cuugccaugu                                                   20


<210>  9086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9086
ugccauguga uugaucucug                                                   20


<210>  9087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9087
gcacauguag gcuccccuuc                                                   20


<210>  9088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9088
ccuucaccuu cugccaucag                                                   20


<210>  9089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9089
ccagaagcag augcuggugc                                                   20


<210>  9090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9090
aggaagcaug gcaccagcau                                                   20


<210>  9091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9091
ccaggaagca uggcaccagc                                                   20


<210>  9092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9092
ugauucugca agcucuccag                                                   20


<210>  9093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9093
ccuucaggua uuccuuuaua                                                   20


<210>  9094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9094
cucuuuaaga aguguugccu                                                   20


<210>  9095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9095
cuuuaagaag uguugccuuu                                                   20


<210>  9096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9096
uuaagaagug uugccuuugc                                                   20


<210>  9097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9097
cuuagucauc ccuucugccu                                                   20


<210>  9098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9098
acaaaugcag gcagaaggga                                                   20


<210>  9099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9099
cauccagaug cucuacaaau                                                   20


<210>  9100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9100
ugacuuuccc agcaggccua                                                   20


<210>  9101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9101
acaauacagc agagguaucu                                                   20


<210>  9102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9102
gcuguauugu agagaccaca                                                   20


<210>  9103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9103
gauaccucug cuguauugua                                                   20


<210>  9104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9104
gagagguuga gugacuugcu                                                   20


<210>  9105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9105
gagccucaga uaccucugcu                                                   20


<210>  9106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9106
cggagccuca gauaccucug                                                   20


<210>  9107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9107
accucucgga gccucagaua                                                   20


<210>  9108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9108
uggcugcaca accaguaaau                                                   20


<210>  9109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9109
aauauuuacu gguugugcag                                                   20


<210>  9110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9110
aaagcccaug auuuuuuccc                                                   20


<210>  9111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9111
auuuauucug acuggggcau                                                   20


<210>  9112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9112
cccaugcccc agucagaaua                                                   20


<210>  9113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9113
ugguggcccu gcccaaaggc                                                   20


<210>  9114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9114
acgggccugg ucgcuccugg                                                   20


<210>  9115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9115
cuacgggccu ggucgcuccu                                                   20


<210>  9116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9116
guaccugcac ccagcucucu                                                   20


<210>  9117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9117
acaacagguu uuccucugua                                                   20


<210>  9118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9118
uauaggccaa cuauuauuau                                                   20


<210>  9119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9119
guugugucuc uuuuguugua                                                   20


<210>  9120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9120
uuuguuguaa uuuguaagua                                                   20


<210>  9121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9121
ccccuacuua caaauuacaa                                                   20


<210>  9122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9122
uugcaugggg ccaggauccg                                                   20


<210>  9123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9123
acggauccug gccccaugca                                                   20


<210>  9124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9124
uucagcacca ccacguaggu                                                   20


<210>  9125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9125
uccuucagca ccaccacgua                                                   20


<210>  9126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9126
cgcagucaga gcgcacugcc                                                   20


<210>  9127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9127
cagucagagc gcacugcccg                                                   20


<210>  9128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9128
gacugcgaga ggugggucuc                                                   20


<210>  9129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9129
ccaagauccu gcaugucuuc                                                   20


<210>  9130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9130
ucuucaccag gaagccagga                                                   20


<210>  9131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9131
agcaggucgc cacucaucuu                                                   20


<210>  9132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9132
ccagcuccag caggucgcca                                                   20


<210>  9133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9133
auacauacuu gcuguccccu                                                   20


<210>  9134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9134
ucuuucaaau gaagauagac                                                   20


<210>  9135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9135
ucgucuuuca aaugaagaua                                                   20


<210>  9136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9136
gaacuucagu cuccucgucu                                                   20


<210>  9137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9137
accccuagcu gucugugugg                                                   20


<210>  9138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9138
acugaacauc ccagggccuu                                                   20


<210>  9139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9139
ggcuccacug aacaucccag                                                   20


<210>  9140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9140
aggguccaaa auuccuuuga                                                   20


<210>  9141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9141
ggauagcaac agcuucaaag                                                   20


<210>  9142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9142
ucccuccugg augucacauc                                                   20


<210>  9143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9143
cuccuggaug ucacaucuuc                                                   20


<210>  9144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9144
uggaugucac aucuucggug                                                   20


<210>  9145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9145
accgaagaug ugacauccag                                                   20


<210>  9146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9146
ucacccuggc ccuagugcuu                                                   20


<210>  9147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9147
cccuggcccu agugcuucaa                                                   20


<210>  9148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9148
uuuccuggcc ucuaacuuga                                                   20


<210>  9149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9149
aacuugauga gagcgugugu                                                   20


<210>  9150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9150
ucaaguuaga ggccaggaaa                                                   20


<210>  9151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9151
caucaaguua gaggccagga                                                   20


<210>  9152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9152
acauggcagg cggugcuucu                                                   20


<210>  9153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9153
ugcagacagu gaggccccac                                                   20


<210>  9154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9154
cugucugcag gaggcuaaga                                                   20


<210>  9155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9155
gacccugccc auuacacgcu                                                   20


<210>  9156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9156
agacucugac ccugcccauu                                                   20


<210>  9157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9157
uagcugcacu gcacugcugc                                                   20


<210>  9158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9158
gcauaccgug gcugaacagc                                                   20


<210>  9159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9159
uaccaaggcc uguggcgcca                                                   20


<210>  9160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9160
acuuagacua cggguuucca                                                   20


<210>  9161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9161
ucuacuuaga cuacggguuu                                                   20


<210>  9162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9162
acacacguuu accaagugcc                                                   20


<210>  9163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9163
gcagcacaca guaggcacuu                                                   20


<210>  9164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9164
ggccuuuccc uugagcuuac                                                   20


<210>  9165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9165
agggaaaggc cugagcugug                                                   20


<210>  9166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9166
ugaacuguaa gcucaaggga                                                   20


<210>  9167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9167
uccugaacug uaagcucaag                                                   20


<210>  9168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9168
ccuccugaac uguaagcuca                                                   20


<210>  9169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9169
gccuugggga gagacgaaga                                                   20


<210>  9170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9170
ccaaggcuga gcacauuguc                                                   20


<210>  9171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9171
ccccaaggcu gagcacauug                                                   20


<210>  9172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9172
ugccugucau cuggugcuau                                                   20


<210>  9173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9173
gaggagagua ggccaagcag                                                   20


<210>  9174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9174
gagcagcugc ccuggccugu                                                   20


<210>  9175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9175
ucugagcagc ugcccuggcc                                                   20


<210>  9176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9176
ccucugagca gcugcccugg                                                   20


<210>  9177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9177
auggcaaaug ccugcagccu                                                   20


<210>  9178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9178
cgauggcaaa ugccugcagc                                                   20


<210>  9179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9179
aacccaggcu gguaugaugc                                                   20


<210>  9180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9180
ggguuagaca gccaauaagg                                                   20


<210>  9181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9181
cugagccuca uuccucuauc                                                   20


<210>  9182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9182
gagccucauu ccucuaucug                                                   20


<210>  9183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9183
gagaggugaa gggauuugcu                                                   20


<210>  9184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9184
uuccucuauc uguaaaccag                                                   20


<210>  9185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9185
aucuguaaac caguuauaau                                                   20


<210>  9186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9186
uuuaguccuu aaaugaaugu                                                   20


<210>  9187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9187
cugaaguggg ggcagguuaa                                                   20


<210>  9188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9188
ggggauacga aggcauccag                                                   20


<210>  9189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9189
ugccacaacu agucccugga                                                   20


<210>  9190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9190
uuacccuuca gaccuaagug                                                   20


<210>  9191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9191
ccuuacccuu cagaccuaag                                                   20


<210>  9192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9192
gcccaguugg agccgguggc                                                   20


<210>  9193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9193
aacugggcag agggaaagcu                                                   20


<210>  9194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9194
augccaccgg cuccaacugg                                                   20


<210>  9195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9195
uccaugccac cggcuccaac                                                   20


<210>  9196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9196
ccuccaugcc accggcucca                                                   20


<210>  9197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9197
ggugauuccc cacaggcagc                                                   20


<210>  9198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9198
cugcgcaugg cagcggugaa                                                   20


<210>  9199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9199
ugacucccug cgcauggcag                                                   20


<210>  9200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9200
cuaccuccug acucccugcg                                                   20


<210>  9201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9201
cucccuaccu ccugacuccc                                                   20


<210>  9202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9202
aaaaaaaaaa aaaauggugu                                                   20


<210>  9203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9203
guugcccaga cuggagugca                                                   20


<210>  9204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9204
agucugggca acagagucuc                                                   20


<210>  9205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9205
gccucccggg uucaagcuca                                                   20


<210>  9206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9206
cggguucaag cucacugcaa                                                   20


<210>  9207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9207
cugcaaccuc ugccucccgg                                                   20


<210>  9208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9208
gccucccggg uucaagcgau                                                   20


<210>  9209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9209
cggguucaag cgauucuccu                                                   20


<210>  9210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9210
ugccucagcc ucccgaguag                                                   20


<210>  9211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9211
gccucccgag uagcugggac                                                   20


<210>  9212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9212
cgaguagcug ggacuacagg                                                   20


<210>  9213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9213
ggaggcugag gcaggagaau                                                   20


<210>  9214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9214
auuaaaaaua caaaaauuag                                                   20


<210>  9215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9215
aacucucgac cucaggugau                                                   20


<210>  9216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9216
cgaccucagg ugauccccca                                                   20


<210>  9217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9217
accucaggug aucccccacc                                                   20


<210>  9218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9218
ggugaucccc caccucggcc                                                   20


<210>  9219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9219
gccucccaaa gugcugggau                                                   20


<210>  9220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9220
caaagugcug ggauuacagg                                                   20


<210>  9221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9221
cgccuguaau cccagcacuu                                                   20


<210>  9222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9222
cagcugcuga ugcacucuug                                                   20


<210>  9223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9223
uguccuucua acuccugcua                                                   20


<210>  9224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9224
ugcuagugcc ucccauuggc                                                   20


<210>  9225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9225
cauuggcuga gcccaacugg                                                   20


<210>  9226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9226
gccaauggga ggcacuagca                                                   20


<210>  9227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9227
cuugcaaagc uuccaguugg                                                   20


<210>  9228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9228
gugcaaacug cagcaccagc                                                   20


<210>  9229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9229
agccugcuca gugcaaacug                                                   20


<210>  9230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9230
agccuucucc agccugcuca                                                   20


<210>  9231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9231
augccuaaau caugacauaa                                                   20


<210>  9232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9232
ggcccuggac uccaugccua                                                   20


<210>  9233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9233
auguccaucc ugcccagagc                                                   20


<210>  9234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9234
gggcaggaug gacauggagu                                                   20


<210>  9235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9235
cagacaagau gucaaguuca                                                   20


<210>  9236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9236
augccagacc guguugcagg                                                   20


<210>  9237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9237
cauaucccug caacacgguc                                                   20


<210>  9238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9238
cagccugauc aaggagcgag                                                   20


<210>  9239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9239
uugaucaggc ugggagccca                                                   20


<210>  9240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9240
cuccuugauc aggcugggag                                                   20


<210>  9241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9241
ggcuccuagu cuguccuccg                                                   20


<210>  9242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9242
uagucugucc uccggggcac                                                   20


<210>  9243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9243
ggggcacuag cagggacaag                                                   20


<210>  9244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9244
caccuugucc cugcuagugc                                                   20


<210>  9245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9245
gcuuaagcca uuuggacagc                                                   20


<210>  9246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9246
cuggcuucug caggccuuga                                                   20


<210>  9247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9247
ggcuucugca ggccuugaag                                                   20


<210>  9248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9248
auguagucga cauggggcaa                                                   20


<210>  9249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9249
ucgauguagu cgacaugggg                                                   20


<210>  9250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9250
ucugucuuug cccagagcau                                                   20


<210>  9251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9251
gucuuugccc agagcauccc                                                   20


<210>  9252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9252
gggcaaagac agaggagucc                                                   20


<210>  9253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9253
agguuccacg ggaugcucug                                                   20


<210>  9254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9254
acgguaccgg gcggaugaau                                                   20


<210>  9255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9255
gauggggugg ggcagggcac                                                   20


<210>  9256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9256
gcccuggccu ggccucccug                                                   20


<210>  9257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9257
cugcuggugg uuuccacuuc                                                   20


<210>  9258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9258
gggggcuuug ggacucagca                                                   20


<210>  9259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9259
gcaccuccac ugaccccuuu                                                   20


<210>  9260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9260
acugaccccu uuuuuucugu                                                   20


<210>  9261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9261
uuuccuucuu uucucuuguu                                                   20


<210>  9262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9262
uguuuuccuu uucucaccau                                                   20


<210>  9263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9263
ccauuuggaa uggcccagca                                                   20


<210>  9264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9264
uuccaaggua agugcagccu                                                   20


<210>  9265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9265
accuagggcc cccaggccuc                                                   20


<210>  9266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9266
auaacuccca gugcccugca                                                   20


<210>  9267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9267
cagugcccug cagacuggac                                                   20


<210>  9268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9268
gccuaccuuc cuguuuugcu                                                   20


<210>  9269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9269
accugccucc agcuccguuu                                                   20


<210>  9270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9270
agcuccguuu ggcuuccugg                                                   20


<210>  9271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9271
guuuggcuuc cuggggcucc                                                   20


<210>  9272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9272
cugccugggc cacuuugugu                                                   20


<210>  9273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9273
aggccuuucu uuccacuguu                                                   20


<210>  9274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9274
gccuggugug gccuggcuau                                                   20


<210>  9275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9275
cuuccauagc caggccacac                                                   20


<210>  9276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9276
cucccuucca uagccaggcc                                                   20


<210>  9277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9277
ucccucccuu ccauagccag                                                   20


<210>  9278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9278
uccucccucc cuuccauagc                                                   20


<210>  9279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9279
agaugcaccu ggccugagga                                                   20


<210>  9280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9280
ggccaggugc aucuagaguc                                                   20


<210>  9281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9281
ucaggccagg ugcaucuaga                                                   20


<210>  9282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9282
ccucaggcca ggugcaucua                                                   20


<210>  9283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9283
aacuuaacac aguccaacua                                                   20


<210>  9284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9284
caccaugggc accucaaacu                                                   20


<210>  9285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9285
agaccucaca ccaugggcac                                                   20


<210>  9286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9286
gcgcagagau gaugcaaugu                                                   20


<210>  9287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9287
gcgcugagcu ccagaccuca                                                   20


<210>  9288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9288
gcguccuggc accauguugc                                                   20


<210>  9289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9289
gcuuucaccc cuuaccgguu                                                   20


<210>  9290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9290
ugggaucuug ggaagccacu                                                   20


<210>  9291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9291
uagaagaaag uggcuuccca                                                   20


<210>  9292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9292
cagguugcug ugagacucca                                                   20


<210>  9293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9293
cagcaaccug ugagaaggac                                                   20


<210>  9294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9294
aaugaguuga aggaugugca                                                   20


<210>  9295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9295
uuggagucuc acagcaaccu                                                   20


<210>  9296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9296
gacauaugca aggucacaca                                                   20


<210>  9297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9297
gaucuguugc aauggcagca                                                   20


<210>  9298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9298
acacccagcc caccagcucu                                                   20


<210>  9299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9299
ggcaagggug gcagcagcag                                                   20


<210>  9300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9300
cuucugcugc ugccacccuu                                                   20


<210>  9301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9301
cuggccacag gcugcccagg                                                   20


<210>  9302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9302
cccuggccac aggcugccca                                                   20


<210>  9303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9303
ucuguaggaa gagccuguuc                                                   20


<210>  9304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9304
guaggaagag ccuguuccuu                                                   20


<210>  9305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9305
uccuacagag gagcuguccu                                                   20


<210>  9306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9306
ccugguugga aaggaacagg                                                   20


<210>  9307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9307
ucaguggagc ccuggagccc                                                   20


<210>  9308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9308
acugaagagg ucucaccugg                                                   20


<210>  9309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9309
agggcuccac ugaagagguc                                                   20


<210>  9310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9310
acaucagugc cucagggacc                                                   20


<210>  9311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9311
gggaccuccc ggagcaggcu                                                   20


<210>  9312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9312
cggagcaggc uaauaucaga                                                   20


<210>  9313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9313
gggagguccc ugaggcacug                                                   20


<210>  9314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9314
gauauuagcc ugcuccggga                                                   20


<210>  9315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9315
uggucucuga uauuagccug                                                   20


<210>  9316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9316
gccagugucc cucuuggucu                                                   20


<210>  9317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9317
gugauccucu gccagugucc                                                   20


<210>  9318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9318
gucccugccu ggacuggggu                                                   20


<210>  9319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9319
guuggaacaa guugauucuc                                                   20


<210>  9320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9320
gcaguccugg aggccagaag                                                   20


<210>  9321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9321
aggacugcag agaaucaacu                                                   20


<210>  9322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9322
cggggggcuc cagggagaag                                                   20


<210>  9323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9323
agggagaagc uucucuugcc                                                   20


<210>  9324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9324
cuggagcccc ccgggagaaa                                                   20


<210>  9325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9325
ugccucuucc gugucccaac                                                   20


<210>  9326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9326
uccguguccc aacagcggca                                                   20


<210>  9327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9327
gucuucacac agccuucucu                                                   20


<210>  9328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9328
gugucucucu ccucuucauu                                                   20


<210>  9329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9329
cuccucuuca uugucucaua                                                   20


<210>  9330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9330
ccucuucauu gucucauaag                                                   20


<210>  9331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9331
ucuucauugu cucauaagga                                                   20


<210>  9332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9332
ucauugucuc auaaggacac                                                   20


<210>  9333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9333
uaaggacacu ugucauugga                                                   20


<210>  9334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9334
aggaugaucu caugugggga                                                   20


<210>  9335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9335
uguggggaac cuuaaccaca                                                   20


<210>  9336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9336
cauccuaacc cccacaaccu                                                   20


<210>  9337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9337
uuggcagcca cuguucccuc                                                   20


<210>  9338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9338
ucucccuugg gccagaagca                                                   20


<210>  9339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9339
cccuugggcc agaagcagac                                                   20


<210>  9340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9340
cuugggccag aagcagacgu                                                   20


<210>  9341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9341
ggggaagcgg gaaggggggc                                                   20


<210>  9342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9342
cacagacacu cgggggaagc                                                   20


<210>  9343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9343
agaagggguu ccacaccccu                                                   20


<210>  9344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9344
agccaagccc uugauaugac                                                   20


<210>  9345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9345
uggagcuguu gggcuggcau                                                   20


<210>  9346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9346
aggaggacuu ccuccagcca                                                   20


<210>  9347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9347
ccaugaauga agaagcugcu                                                   20


<210>  9348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9348
agggcccaug cuuguggccu                                                   20


<210>  9349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9349
aacccagacc cugcacucuu                                                   20


<210>  9350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9350
uaacugugug accuugcaua                                                   20


<210>  9351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9351
cccucucuga ucuucagguu                                                   20


<210>  9352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9352
cugaucuuca gguuccucug                                                   20


<210>  9353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9353
gaucuucagg uuccucugca                                                   20


<210>  9354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9354
gcaaaaggga gguaaugaua                                                   20


<210>  9355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9355
cuuuugcaga ggaaccugaa                                                   20


<210>  9356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9356
cucugggggg cuguuuggag                                                   20


<210>  9357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9357
ggggggcugu uuggaggguu                                                   20


<210>  9358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9358
aaacagcccc ccagagugag                                                   20


<210>  9359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9359
gucagguauu gagugaggug                                                   20


<210>  9360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9360
auaccugaca gagaaaugca                                                   20


<210>  9361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9361
cucaauaccu gacagagaaa                                                   20


<210>  9362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9362
aaacguuauu auugaauggu                                                   20


<210>  9363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9363
ucccccaaca guguauccag                                                   20


<210>  9364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9364
gccuauccag aacuaaucug                                                   20


<210>  9365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9365
cagccuaucc agaacuaauc                                                   20


<210>  9366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9366
gaaggagugc aggcagcugc                                                   20


<210>  9367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9367
uucagagcuc ucagccuauc                                                   20


<210>  9368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9368
cagcugccug cacuccuuca                                                   20


<210>  9369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9369
aggaauccuu uccugauccu                                                   20


<210>  9370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9370
cagcuucaau ccacguucau                                                   20


<210>  9371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9371
ugccucacag cuucaaucca                                                   20


<210>  9372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9372
cuccugccuc acagcuucaa                                                   20


<210>  9373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9373
gucccuucug cacaggccac                                                   20


<210>  9374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9374
ccagccucgg ucccuucugc                                                   20


<210>  9375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9375
uggucucacc agccucgguc                                                   20


<210>  9376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9376
aggucagaug ugaaaggaag                                                   20


<210>  9377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9377
gacuguggcc aaguucuucc                                                   20


<210>  9378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9378
ggcguauggc agggcugccu                                                   20


<210>  9379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9379
ccaggcagcc cugccauacg                                                   20


<210>  9380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9380
caccaggcag cccugccaua                                                   20


<210>  9381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9381
uucccucuca ccaggcagcc                                                   20


<210>  9382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9382
cugcucugga gguaugcaag                                                   20


<210>  9383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9383
ggagguaugc aagcaggacu                                                   20


<210>  9384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9384
agagcaggga gcucauuccc                                                   20


<210>  9385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9385
caccugccag aggccacaga                                                   20


<210>  9386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9386
ccugccagag gccacagagc                                                   20


<210>  9387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9387
ggcaggugag agcccagucc                                                   20


<210>  9388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9388
guggccucug gcaggugaga                                                   20


<210>  9389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9389
ggaaagcucu guggccucug                                                   20


<210>  9390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9390
uccagccucu ggaaagcucu                                                   20


<210>  9391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9391
aaggccucuu ugccccugag                                                   20


<210>  9392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9392
uugccccuga gagugguggc                                                   20


<210>  9393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9393
ggggcaaaga ggccuuggag                                                   20


<210>  9394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9394
caggggcaaa gaggccuugg                                                   20


<210>  9395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9395
ucuugaggcc accuugccac                                                   20


<210>  9396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9396
agaagagcca ccacucucag                                                   20


<210>  9397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9397
cccggggguu uggaagauag                                                   20


<210>  9398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9398
aucuuccaaa cccccgggug                                                   20


<210>  9399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9399
cucuaucuuc caaacccccg                                                   20


<210>  9400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9400
uccgagcugg gccccuuucc                                                   20


<210>  9401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9401
gaugagacac agggcccuuc                                                   20


<210>  9402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9402
cacuggaagg aagcccaagg                                                   20


<210>  9403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9403
cuggaaggaa gcccaaggau                                                   20


<210>  9404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9404
gcuggccaug cuugcagccu                                                   20


<210>  9405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9405
ugacccuguc ccagcaggac                                                   20


<210>  9406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9406
caccagccca cuguccugcu                                                   20


<210>  9407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9407
ccgagcuucc aucugccgcu                                                   20


<210>  9408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9408
gggaggcagc cccacaccuu                                                   20


<210>  9409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9409
uggagcagau ggugguccca                                                   20


<210>  9410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9410
aggagcugua ccuggguucu                                                   20


<210>  9411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9411
caccugggcu aacucagcug                                                   20


<210>  9412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9412
ccugggcuaa cucagcugca                                                   20


<210>  9413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9413
gcugcagccu caguucccuc                                                   20


<210>  9414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9414
guucccuccu cacacacgac                                                   20


<210>  9415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9415
ucacacacga cgaggaacau                                                   20


<210>  9416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9416
cacacgacga ggaacaugga                                                   20


<210>  9417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9417
ucguguguga ggagggaacu                                                   20


<210>  9418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9418
augugcguug uguggcuuac                                                   20


<210>  9419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9419
cuggacguaa gccacacaac                                                   20


<210>  9420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9420
gugcugucuu cuagauaagc                                                   20


<210>  9421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9421
gagggaaaac cuugggcugc                                                   20


<210>  9422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9422
gagcuuccag gcugacggga                                                   20


<210>  9423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9423
ggaagcagcc caagguuuuc                                                   20


<210>  9424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9424
gcuaggagca gacugagcau                                                   20


<210>  9425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9425
uagcagaggc cccgggcugg                                                   20


<210>  9426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9426
gucugcuccu agcagaggcc                                                   20


<210>  9427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9427
gcccaccuug cuggccuugu                                                   20


<210>  9428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9428
auaucuagug guuccucuag                                                   20


<210>  9429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9429
aggguggcga gcacuguuug                                                   20


<210>  9430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9430
ccacccuaga ggaaccacua                                                   20


<210>  9431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9431
agaugucuuc aggucggagc                                                   20


<210>  9432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9432
gaccugaaga caucuggaga                                                   20


<210>  9433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9433
cagcgcucuc agccaccccu                                                   20


<210>  9434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9434
cagccacccc uucccagugu                                                   20


<210>  9435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9435
gccaccccuu cccaguguag                                                   20


<210>  9436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9436
ucaauaggca ucuaccaugu                                                   20


<210>  9437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9437
uaacacacuc agagagcaag                                                   20


<210>  9438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9438
gagagcaagg acuccgccuc                                                   20


<210>  9439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9439
gaguguguua ggagcuuuca                                                   20


<210>  9440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9440
cugagugugu uaggagcuuu                                                   20


<210>  9441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9441
gccucauccc acagccuggg                                                   20


<210>  9442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9442
ucccacagcc ugggaggaga                                                   20


<210>  9443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9443
caggcugugg gaugaggcgg                                                   20


<210>  9444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9444
ucccaggcug ugggaugagg                                                   20


<210>  9445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9445
ccucccaggc ugugggauga                                                   20


<210>  9446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9446
gcaugcuaca gaagaaacca                                                   20


<210>  9447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9447
acugaucagu cccgugggca                                                   20


<210>  9448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9448
gcaggaagcu ccacugauca                                                   20


<210>  9449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9449
agucucggca ggaagcucca                                                   20


<210>  9450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9450
caguucggac ugugcccaga                                                   20


<210>  9451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9451
cacccaccca cuaugcuagu                                                   20


<210>  9452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9452
gagcagccac ugaauugcuc                                                   20


<210>  9453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9453
gagaucccac augaauuuca                                                   20


<210>  9454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9454
guagggggcu aaauaguggc                                                   20


<210>  9455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9455
gucugggugu guguaucugu                                                   20


<210>  9456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9456
caggcucugu cugggugugu                                                   20


<210>  9457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9457
aaauaagguc uggcucacag                                                   20


<210>  9458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9458
agauggcauc aucuggauua                                                   20


<210>  9459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9459
uaaagacaca ucacaggacu                                                   20


<210>  9460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9460
cauaaagaca caucacagga                                                   20


<210>  9461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9461
gccuuucucu cauaaagaca                                                   20


<210>  9462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9462
cucugccuuu cucucauaaa                                                   20


<210>  9463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9463
uguguguguc aaaucucccu                                                   20


<210>  9464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9464
acguggcccc uccugugugu                                                   20


<210>  9465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9465
gucuccacgu ggccccuccu                                                   20


<210>  9466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9466
accucugucu ccacguggcc                                                   20


<210>  9467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9467
aaucuccacc ucugucucca                                                   20


<210>  9468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9468
cgucuuccgg cuucuggugg                                                   20


<210>  9469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9469
gggaagaacc cugccucacg                                                   20


<210>  9470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9470
gcagcgaagg cucugggaag                                                   20


<210>  9471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9471
gggcguguac ccacuucuua                                                   20


<210>  9472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9472
cacacuugcu caccuguccu                                                   20


<210>  9473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9473
ccuguccuga gaugagaauc                                                   20


<210>  9474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9474
ggacagguga gcaagugugg                                                   20


<210>  9475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9475
ucucaggaca ggugagcaag                                                   20


<210>  9476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9476
acucugcagc auauuuggag                                                   20


<210>  9477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9477
gcagcauauu uggaggauca                                                   20


<210>  9478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9478
aaauaugcug cagaguagag                                                   20


<210>  9479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9479
guggcccccg cagugauccu                                                   20


<210>  9480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9480
ggagacccug gggcaggagc                                                   20


<210>  9481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9481
ugagucuucu gaagugccau                                                   20


<210>  9482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9482
ugccccaggg ucuccugagu                                                   20


<210>  9483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9483
gggcugucag ucaaacugcu                                                   20


<210>  9484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9484
gauuccaccu gaggcccugc                                                   20


<210>  9485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9485
gguggaauca gagggcagcc                                                   20


<210>  9486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9486
gcuagcagca accugccuga                                                   20


<210>  9487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9487
gccaggccaa aggaagacuu                                                   20


<210>  9488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9488
cagccaggcc aaaggaagac                                                   20


<210>  9489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9489
gaaacucuca gccaggccaa                                                   20


<210>  9490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9490
agcgcagguc ucagaaacuc                                                   20


<210>  9491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9491
gcuccagcgc aggucucaga                                                   20


<210>  9492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9492
cucccuucuc cauccagcag                                                   20


<210>  9493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9493
cccuucucca uccagcaggc                                                   20


<210>  9494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9494
cuucuccauc cagcaggcug                                                   20


<210>  9495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9495
auccagcagg cuggaccugc                                                   20


<210>  9496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9496
cagaugccag gcagguccag                                                   20


<210>  9497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9497
cccuacuuuc uccuauaccc                                                   20


<210>  9498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9498
cuacuuucuc cuauacccua                                                   20


<210>  9499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9499
uauacccuaa ccuuuguccu                                                   20


<210>  9500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9500
cccagugagu cucuugcagc                                                   20


<210>  9501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9501
cugggggagu cgcccaugca                                                   20


<210>  9502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9502
ugcagcuuuu accccagugc                                                   20


<210>  9503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9503
aagaagcagg cacuggggua                                                   20


<210>  9504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9504
gugacuguuu ucucugaggu                                                   20


<210>  9505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9505
gagguuguga cucgugugag                                                   20


<210>  9506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9506
gagaaaacag ucaccgagcg                                                   20


<210>  9507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9507
ugugaggcag aagcaguccc                                                   20


<210>  9508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9508
cacgagucac aaccucagag                                                   20


<210>  9509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9509
cggggacugc uucugccuca                                                   20


<210>  9510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9510
ugguaucuug uggaguggag                                                   20


<210>  9511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9511
acaagauacc aggagggcuc                                                   20


<210>  9512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9512
acuccacaag auaccaggag                                                   20


<210>  9513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9513
agguccaagc guucuccacu                                                   20


<210>  9514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9514
uggcuccagg uccaagcguu                                                   20


<210>  9515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9515
gacaggaugu augucugggc                                                   20


<210>  9516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9516
aaaaugagcc ggccagcgca                                                   20


<210>  9517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9517
uuuuagagac aggaagcugc                                                   20


<210>  9518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9518
uuugagucuu uaaaucuugu                                                   20


<210>  9519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9519
aaggagaaua acagugaugu                                                   20


<210>  9520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9520
gugagcugug aaaggcuaua                                                   20


<210>  9521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9521
ccgagucugc aagaaagaca                                                   20


<210>  9522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9522
uucauaugaa uaucaauauc                                                   20


<210>  9523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9523
cuaggccucc cuuuccuugu                                                   20


<210>  9524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9524
aggccucccu uuccuugucu                                                   20


<210>  9525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9525
cuuuccuugu cuaugaaaua                                                   20


<210>  9526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9526
cacacuacau ccuauucuau                                                   20


<210>  9527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9527
aaaaaauccu cacacacuac                                                   20


<210>  9528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9528
uuuaaccucc aaaaaauccu                                                   20


<210>  9529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9529
guaguuucug uguguuaacu                                                   20


<210>  9530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9530
uucccuccuc ucccacaaau                                                   20


<210>  9531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9531
ucucccacaa augucgccuu                                                   20


<210>  9532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9532
cccacaaaug ucgccuugga                                                   20


<210>  9533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9533
cacaaauguc gccuuggaaa                                                   20


<210>  9534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9534
gucuuuccaa ggcgacauuu                                                   20


<210>  9535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9535
accaggcugc cuccgucuuu                                                   20


<210>  9536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9536
uagacaccag cauacagagu                                                   20


<210>  9537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9537
guaugcuggu gucuaggaga                                                   20


<210>  9538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9538
auuucccggu ggucacucug                                                   20


<210>  9539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9539
aagucgguga ccaugacccu                                                   20


<210>  9540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9540
ggcacauucu cgaagucggu                                                   20


<210>  9541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9541
ucgggcacau ucucgaaguc                                                   20


<210>  9542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9542
caucagacgg ccgugcuuac                                                   20


<210>  9543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9543
gcccauaucc ccauccugga                                                   20


<210>  9544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9544
aggaugggga uaugggcaga                                                   20


<210>  9545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9545
gggguggcag uccccaccca                                                   20


<210>  9546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9546
uggguugcac cccccccagc                                                   20


<210>  9547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9547
cugccaucag uugugggaag                                                   20


<210>  9548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9548
acccuauaac aaaucagcag                                                   20


<210>  9549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9549
ugugguccuu guguucgucg                                                   20


<210>  9550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9550
acgaacacaa ggaccacaug                                                   20


<210>  9551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9551
acugccaagg gaagggcacg                                                   20


<210>  9552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9552
uagguaagug auggccccag                                                   20


<210>  9553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9553
cuccaucugg accuggccug                                                   20


<210>  9554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9554
ccaucuggac cuggccuggg                                                   20


<210>  9555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9555
aucuggaccu ggccugggag                                                   20


<210>  9556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9556
caggccaggu ccagauggag                                                   20


<210>  9557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9557
cugggcccag cccaagccac                                                   20


<210>  9558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9558
cccugggccc agcccaagcc                                                   20


<210>  9559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9559
uaaccaagaa ugcuguggca                                                   20


<210>  9560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9560
gccgcagagc cagagaacca                                                   20


<210>  9561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9561
gcggcagagg cugccacagc                                                   20


<210>  9562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9562
ggcucugcgg cagaggcugc                                                   20


<210>  9563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9563
gguucucugg cucugcggca                                                   20


<210>  9564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9564
uggccacugg gaacccugcc                                                   20


<210>  9565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9565
uggggccugg guuucuucau                                                   20


<210>  9566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9566
cugggcuacc ugcaugaccc                                                   20


<210>  9567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9567
ccuuuuaaaa uccggugaug                                                   20


<210>  9568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9568
acauugaaga uaacauaaca                                                   20


<210>  9569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9569
aggugaucua agcaaacuuu                                                   20


<210>  9570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9570
agucccucca cauugaagau                                                   20


<210>  9571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9571
gagaccaggg gacucacuca                                                   20


<210>  9572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9572
gagguaugca agcagaagau                                                   20


<210>  9573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9573
cucacuugca ugacugggcc                                                   20


<210>  9574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9574
cuugcaugac ugggcccugc                                                   20


<210>  9575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9575
accacaucug ccuggccagu                                                   20


<210>  9576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9576
gccaguuccu ccaccacauc                                                   20


<210>  9577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9577
acuggacuuc auaggggggc                                                   20


<210>  9578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9578
gggggccggu ggacagagaa                                                   20


<210>  9579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9579
guccaccggc ccccagaguc                                                   20


<210>  9580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9580
ucucugucca ccggccccca                                                   20


<210>  9581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9581
cucuucucug uccaccggcc                                                   20


<210>  9582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9582
cccuuacuga cuuccuucug                                                   20


<210>  9583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9583
cuuacugacu uccuucugug                                                   20


<210>  9584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9584
augucuggcc acagaaggaa                                                   20


<210>  9585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9585
guacagcaug uccuggggcu                                                   20


<210>  9586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9586
ggacugguuu cgucaacuau                                                   20


<210>  9587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9587
cuggacuggu uucgucaacu                                                   20


<210>  9588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9588
ccucucugga cugguuucgu                                                   20


<210>  9589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9589
agcuggggaa cucgcuggga                                                   20


<210>  9590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9590
cugggaaaac ugucagcucu                                                   20


<210>  9591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9591
gggcagcagc uugacuucca                                                   20


<210>  9592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9592
ggugcuggca gaggcagccc                                                   20


<210>  9593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9593
gccagcacca gagccagugu                                                   20


<210>  9594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9594
gccuuugaaa caggcuagug                                                   20


<210>  9595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9595
ugggccuucu cagccuuuga                                                   20


<210>  9596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9596
accaguucug cccugagacu                                                   20


<210>  9597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9597
gggcagaacu gguggagcac                                                   20


<210>  9598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9598
guaggaaagu cucagggcag                                                   20


<210>  9599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9599
gcucagucag gucaguuccu                                                   20


<210>  9600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9600
gucaggucag uuccugaagg                                                   20


<210>  9601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9601
acacacugac cuucaggaac                                                   20


<210>  9602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9602
ccuccacaca cugaccuuca                                                   20


<210>  9603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9603
ggccucugga ggacuuccug                                                   20


<210>  9604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9604
ggaggacuuc cuggagaagu                                                   20


<210>  9605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9605
agaggccaga gcaccaggcc                                                   20


<210>  9606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9606
aggaaguccu ccagaggcca                                                   20


<210>  9607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9607
acagucacua uugccuuccu                                                   20


<210>  9608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9608
ucuguaagca ggugauugug                                                   20


<210>  9609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9609
guaagcaggu gauugugugu                                                   20


<210>  9610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9610
gacuggacac acaaucaccu                                                   20


<210>  9611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9611
gugcucagac uggacacaca                                                   20


<210>  9612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9612
ugccuguaau cccagcacuu                                                   20


<210>  9613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9613
caaagugcug ggauuacagg                                                   20


<210>  9614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9614
gccucccaaa gugcugggau                                                   20


<210>  9615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9615
ggugaucugc ccaccucggc                                                   20


<210>  9616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9616
ugaccucagg ugaucugccc                                                   20


<210>  9617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9617
aacuccugac cucaggugau                                                   20


<210>  9618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9618
acuaaaaaua caaaaauuag                                                   20


<210>  9619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9619
caaguagcug ggauacagac                                                   20


<210>  9620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9620
ugccuuagcc ucccaaguag                                                   20


<210>  9621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9621
uggguucaag cgauucuccu                                                   20


<210>  9622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9622
accuccuggg uucaagcgau                                                   20


<210>  9623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9623
cugcaaccuc caccuccugg                                                   20


<210>  9624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9624
gcucacugca accuccaccu                                                   20


<210>  9625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9625
ggcuggauug caguggcacg                                                   20


<210>  9626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9626
aucacucagg cuggauugca                                                   20


<210>  9627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9627
cucuaucacu caggcuggau                                                   20


<210>  9628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9628
aaaauaaaua aguaaauaac                                                   20


<210>  9629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9629
acacucagug ccacuccacu                                                   20


<210>  9630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9630
gugccacucc acucccuccc                                                   20


<210>  9631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9631
acucccuccc uccguggugu                                                   20


<210>  9632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9632
cucccuccgu ggugugaggg                                                   20


<210>  9633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9633
cuccguggug ugaggggccu                                                   20


<210>  9634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9634
guggugugag gggccucacu                                                   20


<210>  9635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9635
caccacggag ggagggagug                                                   20


<210>  9636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9636
cuagcugucu ccuaggagga                                                   20


<210>  9637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9637
uaggaggagc auggcuguga                                                   20


<210>  9638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9638
uaggagacag cuagugaggc                                                   20


<210>  9639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9639
uccuaggaga cagcuaguga                                                   20


<210>  9640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9640
cagccaugcu ccuccuagga                                                   20


<210>  9641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9641
auccuuggcc acggcuccug                                                   20


<210>  9642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9642
uggagacauc uuagaggcca                                                   20


<210>  9643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9643
aggagccgug gccaaggaug                                                   20


<210>  9644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9644
aagaugucuc caggagccgu                                                   20


<210>  9645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9645
cacaccucau uugacagggg                                                   20


<210>  9646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9646
uuugacaggg gagaagcugu                                                   20


<210>  9647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9647
ccugucaaau gagguguggg                                                   20


<210>  9648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9648
ggcccugaug ugcaagggga                                                   20


<210>  9649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9649
agucuccagg ccacugggcc                                                   20


<210>  9650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9650
aggccacugg gccagagcuc                                                   20


<210>  9651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9651
ggcccagugg ccuggagacu                                                   20


<210>  9652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9652
caggcuggca gaggguuaga                                                   20


<210>  9653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9653
gccagccugu gagcucuggc                                                   20


<210>  9654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9654
cgccuguaau cuuagcacuu                                                   20


<210>  9655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9655
caaagugcua agauuacagg                                                   20


<210>  9656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9656
cgccuugccc ucccaaagug                                                   20


<210>  9657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9657
ugauccuccc gccuugcccu                                                   20


<210>  9658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9658
auguccugac cucaugaucc                                                   20


<210>  9659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9659
acuaaaacua caaaaaauua                                                   20


<210>  9660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9660
ggaggcugag gcaggagaau                                                   20


<210>  9661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9661
ugaguagcug ggacuacagg                                                   20


<210>  9662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9662
gccuccugag uagcugggac                                                   20


<210>  9663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9663
ugccucagcc uccugaguag                                                   20


<210>  9664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9664
cggguucacg ccauucuccu                                                   20


<210>  9665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9665
gccucccggg uucacgccau                                                   20


<210>  9666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9666
cugcaagcuc cgccucccgg                                                   20


<210>  9667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9667
gcucacugca agcuccgccu                                                   20


<210>  9668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9668
agccugggca auagagcgag                                                   20


<210>  9669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9669
auugcccagg cuggagugca                                                   20


<210>  9670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9670
cucuauugcc caggcuggag                                                   20


<210>  9671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9671
gucuggaaag aaaaaaaaaa                                                   20


<210>  9672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9672
uuuuuuuuuu uuucuuucca                                                   20


<210>  9673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9673
ugcuacuguc aacaguaaca                                                   20


<210>  9674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9674
cccauuuugg ugcaggccau                                                   20


<210>  9675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9675
acucccccau uuuggugcag                                                   20


<210>  9676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9676
guggcacucc acucccccau                                                   20


<210>  9677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9677
agggugggga guuaugguau                                                   20


<210>  9678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9678
ccacccuuga gggugugguu                                                   20


<210>  9679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9679
augccuagga ccccccauac                                                   20


<210>  9680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9680
caggauuguc uaaagaauua                                                   20


<210>  9681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9681
gugaaacagg gacaguugcu                                                   20


<210>  9682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9682
ccagcugugu ggccccgccc                                                   20


<210>  9683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9683
guucaaguuu gugugggucc                                                   20


<210>  9684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9684
accguggccg caaguguugg                                                   20


<210>  9685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9685
gaugccccuc caccguggcc                                                   20


<210>  9686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9686
gagaguggcg ggggaaguug                                                   20


<210>  9687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9687
gaggccuggc ucagaugccc                                                   20


<210>  9688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9688
cugaggccug gcucagaugc                                                   20


<210>  9689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9689
uuccucugag gcucauccuc                                                   20


<210>  9690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9690
gaggcucauc cucuuggugc                                                   20


<210>  9691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9691
gaggaaugag aagggcacac                                                   20


<210>  9692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9692
uccucuuggu gccucucuuu                                                   20


<210>  9693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9693
uggugccucu cuuucaugga                                                   20


<210>  9694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9694
cuuucaugga aagggauaau                                                   20


<210>  9695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9695
uucauggaaa gggauaauaa                                                   20


<210>  9696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9696
caauaaccuu auuaucccuu                                                   20


<210>  9697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9697
ggggauccuc acaauaaccu                                                   20


<210>  9698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9698
gucuaagcgu cugaauauac                                                   20


<210>  9699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9699
gugccuggcu cugucuaagc                                                   20


<210>  9700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9700
gcagaaccuu gaccaauaca                                                   20


<210>  9701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9701
uaauauauac auccuacugg                                                   20


<210>  9702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9702
ugugaccgug cgggcuggca                                                   20


<210>  9703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9703
guauugcaac aucaaauucu                                                   20


<210>  9704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9704
cagggaagaa ggaauucugc                                                   20


<210>  9705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9705
gucuguucuc uuaaggccuu                                                   20


<210>  9706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9706
uaaggccuuc aacugauuaa                                                   20


<210>  9707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9707
uuuaaucagu ugaaggccuu                                                   20


<210>  9708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9708
auaacuuggg caggccucau                                                   20


<210>  9709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9709
cuauaacuug ggcaggccuc                                                   20


<210>  9710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9710
gucuucugau uuaaauguua                                                   20


<210>  9711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9711
gugccuguaa gggaggggcu                                                   20


<210>  9712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9712
cuuacaggca cagagugaug                                                   20


<210>  9713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9713
ccuuucccag ccccucccuu                                                   20


<210>  9714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9714
ccaaggggug accuuggcuu                                                   20


<210>  9715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9715
caggccugga guuuauucgg                                                   20


<210>  9716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9716
aggccuggga ggaacaaagc                                                   20


<210>  9717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9717
acgccgccug ccagcgccug                                                   20


<210>  9718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9718
ccaggcgcug gcaggcggcg                                                   20


<210>  9719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9719
acuccccagc cucagcuccc                                                   20


<210>  9720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9720
ccagccucag cucccgaggu                                                   20


<210>  9721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9721
gcucccgagg uaggugcugg                                                   20


<210>  9722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9722
cgagguaggu gcuggggcug                                                   20


<210>  9723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9723
ggagcugagg cuggggagua                                                   20


<210>  9724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9724
gcccccuacc cgcgccuugg                                                   20


<210>  9725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9725
gcccuccgcc cccuacccgc                                                   20


<210>  9726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9726
gcccuccgcc cuccgccccc                                                   20


<210>  9727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9727
cuccgcccuc cgcccuccgc                                                   20


<210>  9728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9728
aggaacgugc cacaagaagc                                                   20


<210>  9729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9729
uuccaaagcc agaaggguuc                                                   20


<210>  9730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9730
gacgacuccu uccaaagcca                                                   20


<210>  9731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9731
cgcauggcgg gggucucuga                                                   20


<210>  9732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9732
ccagccuccc gcauggcggg                                                   20


<210>  9733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9733
aaaccuccau caucgcagag                                                   20


<210>  9734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9734
aucaucgcag agucugaaua                                                   20


<210>  9735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9735
gcgaugaugg agguuucgag                                                   20


<210>  9736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9736
cccuccugaa ggucuucugg                                                   20


<210>  9737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9737
cuccugaagg ucuucuggua                                                   20


<210>  9738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9738
ugaaggucuu cugguacccg                                                   20


<210>  9739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9739
ccaucuccau ccccaggccc                                                   20


<210>  9740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9740
auccccaggc ccugcguccu                                                   20


<210>  9741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9741
gcccaauacu cuuugggccu                                                   20


<210>  9742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9742
uugggccucc cuguugucca                                                   20


<210>  9743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9743
cuguugucca gcucucuccg                                                   20


<210>  9744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9744
cuccgcggcu ccaugacuga                                                   20


<210>  9745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9745
ccgcggcucc augacugaca                                                   20


<210>  9746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9746
gcggcuccau gacugacaac                                                   20


<210>  9747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9747
augacugaca acuugagcaa                                                   20


<210>  9748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9748
aguugucagu cauggagccg                                                   20


<210>  9749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9749
cauucacauu agccuugcuc                                                   20


<210>  9750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9750
accgcuccca uucacauuag                                                   20


<210>  9751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9751
gaccucucac ccgaggaaca                                                   20


<210>  9752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9752
cacccgagga acauccacag                                                   20


<210>  9753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9753
cccgaggaac auccacagag                                                   20


<210>  9754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9754
ggugagaggu cugagcccuc                                                   20


<210>  9755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9755
guggauguuc cucgggugag                                                   20


<210>  9756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9756
gugucugugu ccccgcagcc                                                   20


<210>  9757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9757
gcccugagga gcuggggggc                                                   20


<210>  9758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9758
gggccgaggc uccgugucug                                                   20


<210>  9759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9759
ucagggccga ggcuccgugu                                                   20


<210>  9760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9760
ucugacccac cacuccucca                                                   20


<210>  9761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9761
gacccaccac uccuccagug                                                   20


<210>  9762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9762
uccaguguca ggacacugcg                                                   20


<210>  9763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9763
agugucagga cacugcgggu                                                   20


<210>  9764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9764
gcaaccccca cccccaacgc                                                   20


<210>  9765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9765
gccuuguccu cucaguuucc                                                   20


<210>  9766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9766
caguuucccc ccguggcacu                                                   20


<210>  9767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9767
guuucccccc guggcacuua                                                   20


<210>  9768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9768
cccacuagga uguaaacucc                                                   20


<210>  9769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9769
acaggggcau ugggaaugcu                                                   20


<210>  9770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9770
gucccuacca uagccaggca                                                   20


<210>  9771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9771
ccucuguccc uaccauagcc                                                   20


<210>  9772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9772
ggcaccccug ccccgcccug                                                   20


<210>  9773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9773
uaaggaaaau cugacugccc                                                   20


<210>  9774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9774
aauguccccu ccuaaggaaa                                                   20


<210>  9775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9775
ggccuugcca gcugggcugg                                                   20


<210>  9776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9776
gcaaccccuc ucuugggcuc                                                   20


<210>  9777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9777
cuugggcucc uuucucugcc                                                   20


<210>  9778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9778
ugggcuccuu ucucugccac                                                   20


<210>  9779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9779
uuucucugcc acccaccucc                                                   20


<210>  9780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9780
gccacccacc uccucaccuu                                                   20


<210>  9781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9781
ucaccuuucc aggucaucac                                                   20


<210>  9782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9782
ccuuuccagg ucaucacagu                                                   20


<210>  9783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9783
uugccccagg ggaggacauc                                                   20


<210>  9784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9784
ccuggggcaa agagguccac                                                   20


<210>  9785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9785
agcgacugca gcaccugcuu                                                   20


<210>  9786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9786
gugacacaaa gcaggugcug                                                   20


<210>  9787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9787
gccaccguga ugcuaacagc                                                   20


<210>  9788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9788
agugccaggc ucugugcagg                                                   20


<210>  9789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9789
gugcaggggg accagagaug                                                   20


<210>  9790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9790
ggucccccug cacagagccu                                                   20


<210>  9791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9791
gucugaugag ggaggcgagu                                                   20


<210>  9792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9792
ucagacugag uguccuugaa                                                   20


<210>  9793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9793
cucaucagac ugaguguccu                                                   20


<210>  9794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9794
ccucccucau cagacugagu                                                   20


<210>  9795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9795
gugcacucgc cucccucauc                                                   20


<210>  9796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9796
uguuuccucu gugcacucgc                                                   20


<210>  9797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9797
aauacagccc ugaccucgug                                                   20


<210>  9798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9798
cucuaauaca gcccugaccu                                                   20


<210>  9799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9799
gggcucccuc uaauacagcc                                                   20


<210>  9800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9800
ucugggcucc cucuaauaca                                                   20


<210>  9801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9801
ggcugggcag gugccuccuc                                                   20


<210>  9802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9802
gacccucggg cugggcaggu                                                   20


<210>  9803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9803
aagaugccuu cucugacccu                                                   20


<210>  9804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9804
uccaagaugc cuucucugac                                                   20


<210>  9805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9805
cgaucaaaug ucccuccucc                                                   20


<210>  9806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9806
uauucaucca ucaagcuccc                                                   20


<210>  9807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9807
aagccuuggu aguugcuguc                                                   20


<210>  9808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9808
caccucuaag ccuugguagu                                                   20


<210>  9809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9809
cacaccucua agccuuggua                                                   20


<210>  9810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9810
ucucacaccu cuaagccuug                                                   20


<210>  9811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9811
cugaguaagg acugcaggcg                                                   20


<210>  9812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9812
gugagguaag acagccuccu                                                   20


<210>  9813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9813
aagguaagcc gccugcaguc                                                   20


<210>  9814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9814
ucucgaaggu aagccgccug                                                   20


<210>  9815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9815
cuucucgaag guaagccgcc                                                   20


<210>  9816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9816
ugccagugca cacacgcaca                                                   20


<210>  9817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9817
ugccccagca ggggacuccu                                                   20


<210>  9818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9818
gcagacagca ucauggcugc                                                   20


<210>  9819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9819
ggcucggcag acagcaucau                                                   20


<210>  9820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9820
cccuggccga guugaggcag                                                   20


<210>  9821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9821
gccaggguga gcuccggcuc                                                   20


<210>  9822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9822
acucggccag ggugagcucc                                                   20


<210>  9823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9823
gccucaacuc ggccagggug                                                   20


<210>  9824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9824
gccaaagaug ucaucaauga                                                   20


<210>  9825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9825
uugaugacau cuuuggcaga                                                   20


<210>  9826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9826
gggaaccagg ccucauugau                                                   20


<210>  9827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9827
caagccccag ccuggacuug                                                   20


<210>  9828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9828
cccuucuccc uugucugugu                                                   20


<210>  9829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9829
cuucucccuu gucuguguaa                                                   20


<210>  9830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9830
cuugucugug uaaggaggau                                                   20


<210>  9831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9831
uuacacagac aagggagaag                                                   20


<210>  9832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9832
uuuaauccua uuuaaggugg                                                   20


<210>  9833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9833
gaaagggcug ugcaauauuu                                                   20


<210>  9834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9834
auaaaaacac guuaugaaaa                                                   20


<210>  9835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9835
acugucucua uaaaaacacg                                                   20


<210>  9836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9836
ucucuccuac caugaacuaa                                                   20


<210>  9837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9837
cuccuaccau gaacuaaaga                                                   20


<210>  9838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9838
ccuaccauga acuaaagauu                                                   20


<210>  9839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9839
uaccaugaac uaaagauuuc                                                   20


<210>  9840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9840
acagaaaucu uuaguucaug                                                   20


<210>  9841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9841
cucccagcac ccccuccuca                                                   20


<210>  9842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9842
cagcaccccc uccucauccc                                                   20


<210>  9843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9843
ucaucccagg cccuuuuugc                                                   20


<210>  9844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9844
ucccaggccc uuuuugcagg                                                   20


<210>  9845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9845
gggccuacac ggauggccac                                                   20


<210>  9846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9846
ucuggggcgc agcgggcgac                                                   20


<210>  9847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9847
ucaucugggg cgcagcgggc                                                   20


<210>  9848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9848
gcagcuccuc aucuggggcg                                                   20


<210>  9849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9849
aguuucucca ggagugggaa                                                   20


<210>  9850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9850
aggaguggga agcggcgggg                                                   20


<210>  9851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9851
uggagaaacu ggagcagcuc                                                   20


<210>  9852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9852
ccccgccgcu ucccacuccu                                                   20


<210>  9853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9853
augcgcucgc cccgccgcuu                                                   20


<210>  9854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9854
uucgugugug ugugugugug                                                   20


<210>  9855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9855
gggaccccca gcaagccccu                                                   20


<210>  9856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9856
auccuccaga cuccagcucu                                                   20


<210>  9857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9857
agacuccagc ucuucuguaa                                                   20


<210>  9858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9858
agcucuucug uaagcuuaca                                                   20


<210>  9859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9859
ucuguaagcu uacagggcug                                                   20


<210>  9860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9860
uggucuggcc agcccuguaa                                                   20


<210>  9861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9861
ucacuucacg cggcuggggg                                                   20


<210>  9862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9862
cuucacgcgg cugggggcug                                                   20


<210>  9863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9863
agcagccccc agccgcguga                                                   20


<210>  9864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9864
ccagcagccc ccagccgcgu                                                   20


<210>  9865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9865
cuccagcagc ccccagccgc                                                   20


<210>  9866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9866
aggaaacccu ucccgcugug                                                   20


<210>  9867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9867
ccugggugug agcgugcggc                                                   20


<210>  9868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9868
cacccaggug agcauugaaa                                                   20


<210>  9869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9869
cgcggcccug ccgcacgcuc                                                   20


<210>  9870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9870
ggacucagcc aucucuaggc                                                   20


<210>  9871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9871
gccaucucua ggccccucuc                                                   20


<210>  9872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9872
aggccccucu cacucaggug                                                   20


<210>  9873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9873
cacucaggug cuccaugguu                                                   20


<210>  9874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9874
cucaggugcu ccaugguucu                                                   20


<210>  9875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9875
ggugcuccau gguucuggga                                                   20


<210>  9876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9876
augguucugg gagcugagaa                                                   20


<210>  9877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9877
cagaaccaug gagcaccuga                                                   20


<210>  9878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9878
gcucccagaa ccauggagca                                                   20


<210>  9879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9879
aaccagcaaa aaaguggaau                                                   20


<210>  9880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9880
uagcugggca cugcccuucc                                                   20


<210>  9881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9881
ccuagcuggg cacugcccuu                                                   20


<210>  9882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9882
cucuccuagc ugggcacugc                                                   20


<210>  9883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9883
ucacucuccu agcugggcac                                                   20


<210>  9884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9884
agccagaaau gccugccccu                                                   20


<210>  9885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9885
ucaagccaga aaugccugcc                                                   20


<210>  9886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9886
ugugagaggc agagugggug                                                   20


<210>  9887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9887
cacgagcauu aagaccccau                                                   20


<210>  9888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9888
cacacgagca uuaagacccc                                                   20


<210>  9889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9889
gccucucaca cgagcauuaa                                                   20


<210>  9890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9890
acccacucug ccucucacac                                                   20


<210>  9891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9891
acuccaccca cucugccucu                                                   20


<210>  9892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9892
uggauuucuc ucuaucucca                                                   20


<210>  9893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9893
cuaucuccau uuugaaacca                                                   20


<210>  9894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9894
aucuccauuu ugaaaccacu                                                   20


<210>  9895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9895
auuuugaaac cacucugugu                                                   20


<210>  9896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9896
guguuuggaa gaacuuuuga                                                   20


<210>  9897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9897
aaaguucuuc caaacacaga                                                   20


<210>  9898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9898
gaauacucaa aaguucuucc                                                   20


<210>  9899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9899
ugcccaagga agacuguucu                                                   20


<210>  9900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9900
cuccugccca aggaagacug                                                   20


<210>  9901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9901
uuguccccag aaggcugggu                                                   20


<210>  9902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9902
ucaguguccc ugccaggggc                                                   20


<210>  9903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9903
agcacccuca ucaguguccc                                                   20


<210>  9904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9904
aaggcccaag ggggcaagcu                                                   20


<210>  9905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9905
cccccaaaag cguugugggc                                                   20


<210>  9906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9906
accagcugag gccagcaugg                                                   20


<210>  9907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9907
gcugguggag cuguguggac                                                   20


<210>  9908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9908
cagguaggag gcugggcuug                                                   20


<210>  9909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9909
uaccugugag gacguggccc                                                   20


<210>  9910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9910
ccccagggca agcccagccu                                                   20


<210>  9911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9911
ucaccccagg gcaagcccag                                                   20


<210>  9912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9912
uucuccuuau gcacccacug                                                   20


<210>  9913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9913
uuaugcaccc acugcccgcg                                                   20


<210>  9914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9914
cgggcagugg gugcauaagg                                                   20


<210>  9915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9915
caagugugau ccaugagacu                                                   20


<210>  9916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9916
uggaucacac uugugaggac                                                   20


<210>  9917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9917
agccugacuu gcaguuccau                                                   20


<210>  9918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9918
gguucugcca cuuccaugcc                                                   20


<210>  9919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9919
aagggcaugg aaguggcaga                                                   20


<210>  9920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9920
ucaucucagc uuccuccucc                                                   20


<210>  9921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9921
ucucagcuuc cuccuccaua                                                   20


<210>  9922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9922
gcuuccuccu ccauaagagg                                                   20


<210>  9923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9923
uccauaagag ggaaaaaggu                                                   20


<210>  9924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9924
auaagaggga aaaagguauu                                                   20


<210>  9925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9925
uauggaggag gaagcugaga                                                   20


<210>  9926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9926
uuguguugca aggagauggg                                                   20


<210>  9927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9927
uugcaacaca augaggcagg                                                   20


<210>  9928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9928
aggccagugc ccuagaugcu                                                   20


<210>  9929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9929
uggacugcac caccuuaggc                                                   20


<210>  9930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9930
ccuggacugc accaccuuag                                                   20


<210>  9931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9931
agagagaggc ccccggcugg                                                   20


<210>  9932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9932
ggagcugccu cuccuggacu                                                   20


<210>  9933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9933
cuggagcugc cucuccugga                                                   20


<210>  9934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9934
cucuggagcu gccucuccug                                                   20


<210>  9935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9935
uuucagcccc agccgggggc                                                   20


<210>  9936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9936
guuugaauuu cacccugccg                                                   20


<210>  9937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9937
auagcugugu gacuugggca                                                   20


<210>  9938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9938
guaugaggaa augaugagug                                                   20


<210>  9939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9939
uacagagaug uuaaguaauu                                                   20


<210>  9940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9940
ucauuuccuc auacagagau                                                   20


<210>  9941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9941
gguauaggca acuauugacg                                                   20


<210>  9942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9942
uggggcauca agggauggug                                                   20


<210>  9943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9943
gggcaccauc ccuugaugcc                                                   20


<210>  9944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9944
gccucagggc accaucccuu                                                   20


<210>  9945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9945
acccaaccag aacagcucag                                                   20


<210>  9946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9946
ugcuccaccc aaccagaaca                                                   20


<210>  9947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9947
caugcuccac ccaaccagaa                                                   20


<210>  9948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9948
agccuggaau aagaggcuca                                                   20


<210>  9949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9949
uauuccaggc uggaguccca                                                   20


<210>  9950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9950
gaguugauuc ucgucugagc                                                   20


<210>  9951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9951
gagccucuua uuccaggcug                                                   20


<210>  9952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9952
ucugagcacg uccaggggaa                                                   20


<210>  9953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9953
gacgagaauc aacucugagc                                                   20


<210>  9954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9954
gugguucccc uggacgugcu                                                   20


<210>  9955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9955
uguucccaaa cccucagugg                                                   20


<210>  9956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9956
ccuguuccca aacccucagu                                                   20


<210>  9957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9957
cucuccuguu cccaaacccu                                                   20


<210>  9958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9958
cccucacucu ccuguuccca                                                   20


<210>  9959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9959
ucuuuccuga acauccaucc                                                   20


<210>  9960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9960
ccuggacaag ggcaccagcc                                                   20


<210>  9961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9961
ccccuggaca agggcaccag                                                   20


<210>  9962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9962
gucagguuca gggguccugg                                                   20


<210>  9963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9963
aagccaggac cccugaaccu                                                   20


<210>  9964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9964
aaucacgcuc cccuuuggaa                                                   20


<210>  9965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9965
ccuuuggaag ugcucagccg                                                   20


<210>  9966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9966
gccgaugagc ucacaggcac                                                   20


<210>  9967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9967
ucggcugagc acuuccaaag                                                   20


<210>  9968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9968
caggcacaug ucaguuugaa                                                   20


<210>  9969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9969
augaagcgca ccucaaagag                                                   20


<210>  9970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9970
aagagcacca uuuugcagcu                                                   20


<210>  9971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9971
uugaggugcg cuucauggag                                                   20


<210>  9972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9972
gcauguccag ccugcaguuc                                                   20


<210>  9973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9973
gggcagccac ucagcauguc                                                   20


<210>  9974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9974
auguccuagc ugcaagggcu                                                   20


<210>  9975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9975
gaacauggua ggguuguggu                                                   20


<210>  9976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9976
augcuggggc uucgcacgug                                                   20


<210>  9977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9977
cagggacacu gugaagauga                                                   20


<210>  9978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9978
uuccaucuua caaaugagua                                                   20


<210>  9979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9979
uuuguaagau ggaaagagaa                                                   20


<210>  9980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9980
guuuacucau uuguaagaug                                                   20


<210>  9981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9981
guguagcuaa guaaccacua                                                   20


<210>  9982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9982
uaagcccaug gagggcauuc                                                   20


<210>  9983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9983
augggcuuag gagucagaca                                                   20


<210>  9984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9984
gaaugcccuc caugggcuua                                                   20


<210>  9985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9985
cuaugcagcc agcaggcaga                                                   20


<210>  9986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9986
ccccagcccc ucccuaugca                                                   20


<210>  9987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9987
aacucccccc agccccuccc                                                   20


<210>  9988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9988
ggccauagag ccccugccuc                                                   20


<210>  9989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9989
auggccugag augcucaaac                                                   20


<210>  9990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9990
cugucuccau cucugggugg                                                   20


<210>  9991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9991
aucucugggu ggaaagaugg                                                   20


<210>  9992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9992
ggguggaaag augguguuuu                                                   20


<210>  9993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9993
gggaaaacac caucuuucca                                                   20


<210>  9994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9994
gagagguuga auggcucucc                                                   20


<210>  9995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9995
gagccuuagu uucucaggga                                                   20


<210>  9996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9996
cugagccuua guuucucagg                                                   20


<210>  9997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9997
cccaagguca cacagcuggu                                                   20


<210>  9998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9998
caaggucaca cagcugguca                                                   20


<210>  9999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  9999
gcagcugacc agcuguguga                                                   20


<210>  10000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10000
acucugcagc ugaccagcug                                                   20


<210>  10001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10001
uguguucuca acucugcagc                                                   20


<210>  10002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10002
ggccagcauc ucuuuuuuuc                                                   20


<210>  10003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10003
uuuuuucuuu gaguuguuuc                                                   20


<210>  10004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10004
aagaaaaaaa gagaugcugg                                                   20


<210>  10005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10005
ugccucagac cuuaaagaga                                                   20


<210>  10006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10006
gaccuuaaag agagaggguc                                                   20


<210>  10007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10007
uuaaggucug aggcaagagc                                                   20


<210>  10008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10008
cuuuaagguc ugaggcaaga                                                   20


<210>  10009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10009
cucuuuaagg ucugaggcaa                                                   20


<210>  10010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10010
agugcccauc cccaucagac                                                   20


<210>  10011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10011
gucuccagug cccaucccca                                                   20


<210>  10012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10012
gaugugaaau gcugggaugc                                                   20


<210>  10013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10013
gccccaggcu gcagcuccca                                                   20


<210>  10014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10014
cacugggagg uggaggaccu                                                   20


<210>  10015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10015
cagugggagc ugcagccugg                                                   20


<210>  10016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10016
accucccagu gggagcugca                                                   20


<210>  10017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10017
gcacaggcgg cuugugggug                                                   20


<210>  10018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10018
uggccucagc acaggcggcu                                                   20


<210>  10019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10019
cuguggccca cgcacugguu                                                   20


<210>  10020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10020
uugacuuugc auuccagacc                                                   20


<210>  10021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10021
ggagcaggug aagaggcccg                                                   20


<210>  10022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10022
ugaggggccg ggauuccaug                                                   20


<210>  10023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10023
ucaccugcuc cugaggggcc                                                   20


<210>  10024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10024
cgggccucuu caccugcucc                                                   20


<210>  10025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10025
ccugcacagc uuuucugugu                                                   20


<210>  10026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10026
ugcacagcuu uucuguguca                                                   20


<210>  10027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10027
guguggcugg gucuguuuuu                                                   20


<210>  10028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10028
acuuggagua gaaugugcau                                                   20


<210>  10029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10029
aaguggagug ggguacccag                                                   20


<210>  10030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10030
gaaaaaaaua gaucaaucaa                                                   20


<210>  10031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10031
aauuccuggg cucaagcaau                                                   20


<210>  10032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10032
agcaauccuc uggucucagc                                                   20


<210>  10033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10033
ggucucagcc uccccaagug                                                   20


<210>  10034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10034
gccuccccaa guguugggau                                                   20


<210>  10035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10035
ccaaguguug ggauuauagg                                                   20


<210>  10036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10036
ugccuauaau cccaacacuu                                                   20


<210>  10037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10037
cugaucuauu uaacaaaccu                                                   20


<210>  10038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10038
gaucuauuua acaaaccugc                                                   20


<210>  10039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10039
cagcagguuu guuaaauaga                                                   20


<210>  10040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10040
gggucaggag cagcacuggg                                                   20


<210>  10041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10041
ugacccugag acccucccag                                                   20


<210>  10042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10042
gaggacacag agcucacuca                                                   20


<210>  10043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10043
gagcccagug cugcuccuga                                                   20


<210>  10044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10044
guguccucag agcccagugc                                                   20


<210>  10045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10045
cucagccgug acccagaggg                                                   20


<210>  10046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10046
gccgugaccc agagggggug                                                   20


<210>  10047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10047
gggucacggc ugagugagcu                                                   20


<210>  10048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10048
ggcacccccu cugggucacg                                                   20


<210>  10049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10049
gcagggccuu uucuugccuu                                                   20


<210>  10050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10050
gguuucuaga aggcccggcu                                                   20


<210>  10051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10051
ccuuaaaagc caguaggagc                                                   20


<210>  10052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10052
uuaaaagcca guaggagcuc                                                   20


<210>  10053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10053
uacuggcuuu uaaggagagu                                                   20


<210>  10054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10054
ucaaaaggca gcccuaagga                                                   20


<210>  10055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10055
aaaggcagcc cuaaggaguc                                                   20


<210>  10056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10056
uuagggcugc cuuuugagga                                                   20


<210>  10057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10057
uaaaugaacu cagagucagu                                                   20


<210>  10058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10058
gagucaguuu uaaaaugcaa                                                   20


<210>  10059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10059
gaguucauuu aagaguggac                                                   20


<210>  10060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10060
agagcaaaag acagucuugg                                                   20


<210>  10061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10061
aggaaugcac cauccagacc                                                   20


<210>  10062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10062
cgaggaaugc accauccaga                                                   20


<210>  10063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10063
guguacccag ggcaagugga                                                   20


<210>  10064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10064
uccuggcacu ggggagggau                                                   20


<210>  10065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10065
ccagugccag gaagagcacc                                                   20


<210>  10066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10066
ugggccugua ucccucccca                                                   20


<210>  10067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10067
cuccuggagc aucuauuuua                                                   20


<210>  10068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10068
uggagcaucu auuuuagugg                                                   20


<210>  10069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10069
aggagggaga acagcauguc                                                   20


<210>  10070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10070
acuaaaauag augcuccagg                                                   20


<210>  10071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10071
auauuaaugg uuuguuuucu                                                   20


<210>  10072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10072
aucgcaucuu uucaguacuc                                                   20


<210>  10073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10073
caccccauuc ccuuccuugc                                                   20


<210>  10074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10074
cccaccccau ucccuuccuu                                                   20


<210>  10075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10075
cucccacccc auucccuucc                                                   20


<210>  10076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10076
ugaccucucu cccaccccau                                                   20


<210>  10077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10077
ccugaccucu cucccacccc                                                   20


<210>  10078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10078
cugacaaggu ggacgaaaca                                                   20


<210>  10079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10079
uggccuguuu cguccaccuu                                                   20


<210>  10080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10080
gccucauggc cuguuucguc                                                   20


<210>  10081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10081
cugcacaucc ccaccugggg                                                   20


<210>  10082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10082
gguuuccugg uacucccugc                                                   20


<210>  10083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10083
cugguuuccu gguacucccu                                                   20


<210>  10084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10084
uaacuauucc caccucucug                                                   20


<210>  10085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10085
gaggggacag ggccaaguca                                                   20


<210>  10086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10086
gaggcacccc ccaucucaua                                                   20


<210>  10087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10087
ccugacuugg cccugucccc                                                   20


<210>  10088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10088
ggucucaccu gacuuggccc                                                   20


<210>  10089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10089
cugcugacug ugacccucag                                                   20


<210>  10090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10090
gaggagugug gucuggccug                                                   20


<210>  10091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10091
gaggccagac cccugcaugg                                                   20


<210>  10092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10092
ucugaggcca gaccccugca                                                   20


<210>  10093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10093
cacuguggcc uagcugcuga                                                   20


<210>  10094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10094
cuguggccua gcugcugagc                                                   20


<210>  10095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10095
gcagcuaggc cacagugaga                                                   20


<210>  10096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10096
gcucagcagc uaggccacag                                                   20


<210>  10097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10097
ucucagcuca gcagcuaggc                                                   20


<210>  10098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10098
cugcuucugc ccaagguccu                                                   20


<210>  10099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10099
agucucccug cuucugccca                                                   20


<210>  10100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10100
cuccagucuc ccugcuucug                                                   20


<210>  10101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10101
accgccuccc uccagucucc                                                   20


<210>  10102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10102
ggcuggaguc ugaagggagc                                                   20


<210>  10103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10103
agccugagcc ccgccccaac                                                   20


<210>  10104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10104
cuucagacuc cagccugagc                                                   20


<210>  10105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10105
cacccacauc cacccaccag                                                   20


<210>  10106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10106
cccacccaca uccacccacc                                                   20


<210>  10107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10107
cccucuccca cccacaucca                                                   20


<210>  10108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10108
ggccccugga cagauggagu                                                   20


<210>  10109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10109
aucuguccag gggcccgagc                                                   20


<210>  10110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10110
gaaacugaug gccccauagc                                                   20


<210>  10111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10111
ucccucugaa acugauggcc                                                   20


<210>  10112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10112
acggcccuca aaccaggcau                                                   20


<210>  10113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10113
aaccaggcau gaagcaggag                                                   20


<210>  10114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10114
ugcuucaugc cugguuugag                                                   20


<210>  10115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10115
cguguuuggu cagccauggu                                                   20


<210>  10116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10116
cacccaggcg guucugcacc                                                   20


<210>  10117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10117
caccccgcac cucccaccca                                                   20


<210>  10118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10118
gagccagcga gggccgucug                                                   20


<210>  10119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10119
gagcccauuu gggacacaac                                                   20


<210>  10120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10120
cuggcucaga gcccauuugg                                                   20


<210>  10121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10121
cagaaggaug ucggagggag                                                   20


<210>  10122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10122
gacauccuuc ugugaggcca                                                   20


<210>  10123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10123
cuccgacauc cuucugugag                                                   20


<210>  10124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10124
ggcucuggca ggugaccgug                                                   20


<210>  10125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10125
ggcaggugac cguggccugc                                                   20


<210>  10126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10126
caggccacgg ucaccugcca                                                   20


<210>  10127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10127
ucgcaggcca cggucaccug                                                   20


<210>  10128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10128
cugggaccuc ccacguccug                                                   20


<210>  10129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10129
cacguccugg gggccuacgc                                                   20


<210>  10130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10130
ugacuacaca cguguugucu                                                   20


<210>  10131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10131
ggcagcagau ggcaacggcu                                                   20


<210>  10132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10132
caggagcucc agugacagcc                                                   20


<210>  10133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10133
ugggaggccu gcgccaggug                                                   20


<210>  10134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10134
agugacagcc ccaucccagg                                                   20


<210>  10135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10135
ccagacaccc auccugggau                                                   20


<210>  10136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10136
gccccagccc uugacccucc                                                   20


<210>  10137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10137
cucagcccuc cauggccugg                                                   20


<210>  10138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10138
cagcccucca uggccuggca                                                   20


<210>  10139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10139
gcccuccaug gccuggcacg                                                   20


<210>  10140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10140
auggccuggc acgaggggau                                                   20


<210>  10141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10141
ugccaggcca uggagggcug                                                   20


<210>  10142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10142
agggccaggc cagcagcccc                                                   20


<210>  10143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10143
uugccuggaa cucacucacu                                                   20


<210>  10144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10144
cucacucugg gugccuccuc                                                   20


<210>  10145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10145
cucugggugc cuccucccca                                                   20


<210>  10146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10146
gggugccucc uccccaggug                                                   20


<210>  10147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10147
uccccaggug gaggugccag                                                   20


<210>  10148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10148
ccagguggag gugccaggaa                                                   20


<210>  10149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10149
accuggggag gaggcaccca                                                   20


<210>  10150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10150
cucccucacu guggggcauu                                                   20


<210>  10151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10151
cucacugugg ggcauuucac                                                   20


<210>  10152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10152
cuguggggca uuucaccauu                                                   20


<210>  10153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10153
accuguuuga auggugaaau                                                   20


<210>  10154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10154
ggugcugcca gcugcuccca                                                   20


<210>  10155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10155
caaugugccg auguccgugg                                                   20


<210>  10156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10156
auaaaaguca uucugcccac                                                   20


<210>  10157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10157
uguuccgugc caggcauuca                                                   20


<210>  10158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10158
ggucuccacc aaggaggcag                                                   20


<210>  10159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10159
accaaggagg caggauucuu                                                   20


<210>  10160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10160
uugguggaga ccugaggauu                                                   20


<210>  10161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10161
ccuauccaug ggaagaaucc                                                   20


<210>  10162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10162
ccccccaacg auguuugucc                                                   20


<210>  10163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10163
ucuccagcua acuguggaga                                                   20


<210>  10164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10164
agcuaacugu ggagaagccc                                                   20


<210>  10165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10165
acaguuagcu ggagaugagg                                                   20


<210>  10166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10166
cugauuaaug gaggcuuagc                                                   20


<210>  10167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10167
auuaaucagg gagcccccag                                                   20


<210>  10168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10168
ggcuagaugc cauccagaaa                                                   20


<210>  10169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10169
agccucuggc uagaugccau                                                   20


<210>  10170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10170
ggaaaccaag gcacagccug                                                   20


<210>  10171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10171
gcucuaugcc aggcugugcu                                                   20


<210>  10172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10172
augccaggcu gugcuagcaa                                                   20


<210>  10173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10173
ccgcaggcca ccuuugggug                                                   20


<210>  10174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10174
gcagugugca guggugcaug                                                   20


<210>  10175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10175
gccaacccgc uccacuaccc                                                   20


<210>  10176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10176
acuacccggc aggguacaca                                                   20


<210>  10177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10177
gugaaguagg ggugcgaaug                                                   20


<210>  10178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10178
gguuccaggu uucuuccucu                                                   20


<210>  10179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10179
cacagcagga acugagccag                                                   20


<210>  10180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10180
guuccugcug ugugagcuug                                                   20


<210>  10181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10181
gaagccaagc cucuucuuac                                                   20


<210>  10182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10182
ucuuacuuca cccggcuggg                                                   20


<210>  10183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10183
ucauuuuuac ggguaacagu                                                   20


<210>  10184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10184
uuuuuacggg uaacagugag                                                   20


<210>  10185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10185
cuguuacccg uaaaaaugag                                                   20


<210>  10186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10186
gugagugaug gcagaacgau                                                   20


<210>  10187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10187
ccgagcuucc uggucugugu                                                   20


<210>  10188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10188
gccaggccag ugaaucaggc                                                   20


<210>  10189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10189
cccgaccaug ccuuagaagc                                                   20


<210>  10190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10190
cccccgacca ugccuuagaa                                                   20


<210>  10191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10191
uugagcacca gccccaccca                                                   20


<210>  10192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10192
aggagggaca guuguuggcc                                                   20


<210>  10193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10193
cuguugccuu uuuacagcca                                                   20


<210>  10194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10194
guugccuuuu uacagccaac                                                   20


<210>  10195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10195
ugcauagacu ugacugccua                                                   20


<210>  10196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10196
acuauucaac aaacuuaccc                                                   20


<210>  10197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10197
ucaaauacuu ggcuuacuca                                                   20


<210>  10198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10198
agauaaaagu acucaucaaa                                                   20


<210>  10199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10199
uugugccuau ccuaggaaug                                                   20


<210>  10200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10200
ccugaccacc cugacaguca                                                   20


<210>  10201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10201
uccuugguga caggugcccu                                                   20


<210>  10202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10202
uuggugacag gugcccuaca                                                   20


<210>  10203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10203
agaugcucug uuguccugac                                                   20


<210>  10204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10204
guuguccuga ccucccaaug                                                   20


<210>  10205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10205
caaugcccuu uucauucuuu                                                   20


<210>  10206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10206
ccaguaccug gcacacagcc                                                   20


<210>  10207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10207
ggccaggcug ugugccaggu                                                   20


<210>  10208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10208
uuacagaagc aucuggcacu                                                   20


<210>  10209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10209
gauugggugc aauggcucac                                                   20


<210>  10210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10210
caccuguaau cucaguacuu                                                   20


<210>  10211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10211
guacuuuggg aggcugaggc                                                   20


<210>  10212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10212
caaaguacug agauuacagg                                                   20


<210>  10213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10213
gccucccaaa guacugagau                                                   20


<210>  10214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10214
ugccucagcc ucccaaagua                                                   20


<210>  10215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10215
cuguugccca gggucuugaa                                                   20


<210>  10216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10216
auaaaaaaau uuaaaagauu                                                   20


<210>  10217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10217
cuaaucuuuu aaauuuuuuu                                                   20


<210>  10218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10218
ggaggcugau augggaggcu                                                   20


<210>  10219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10219
ugaguagccg ggaccacagg                                                   20


<210>  10220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10220
cauaucagcc uccugaguag                                                   20


<210>  10221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10221
agcaagccuc ccauaucagc                                                   20


<210>  10222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10222
cagcucaagc aagccuccca                                                   20


<210>  10223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10223
gccucccagc ucaagcaagc                                                   20


<210>  10224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10224
cugcacccuc agccucccag                                                   20


<210>  10225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10225
guaacccagg cugcagugca                                                   20


<210>  10226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10226
aggcccucca cucuaaggcu                                                   20


<210>  10227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10227
acucuaaggc uggugaauau                                                   20


<210>  10228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10228
aaggcuggug aauauagcug                                                   20


<210>  10229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10229
cucucucuag acagcccaug                                                   20


<210>  10230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10230
cucucuagac agcccauguc                                                   20


<210>  10231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10231
cucuagacag cccaugucau                                                   20


<210>  10232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10232
cuagacagcc caugucauaa                                                   20


<210>  10233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10233
agacagccca ugucauaagg                                                   20


<210>  10234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10234
ggcaaaauuc cucccagauu                                                   20


<210>  10235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10235
cagauuacau uuucugacaa                                                   20


<210>  10236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10236
ugaaugcuuu ccauauauga                                                   20


<210>  10237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10237
gcccguugga accuaggccu                                                   20


<210>  10238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10238
cucuccuucc ccuccacaga                                                   20


<210>  10239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10239
cuccuucccc uccacagaau                                                   20


<210>  10240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10240
ccuuccccuc cacagaauca                                                   20


<210>  10241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10241
uuccccucca cagaaucaag                                                   20


<210>  10242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10242
acagaaucaa guaucagcug                                                   20


<210>  10243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10243
aaccagcuga uacuugauuc                                                   20


<210>  10244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10244
gugauguugg aacaacuugg                                                   20


<210>  10245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10245
gcaagaacca aguuguucca                                                   20


<210>  10246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10246
ccgaucccug gugaccaccu                                                   20


<210>  10247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10247
cauggguccc cuucccuauu                                                   20


<210>  10248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10248
uuccuagugg ccagcguugc                                                   20


<210>  10249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10249
gucucauucc uaguggccag                                                   20


<210>  10250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10250
caaguggucc ccagcauaga                                                   20


<210>  10251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10251
cccaaguggu ccccagcaua                                                   20


<210>  10252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10252
accaaagcuu uuggcucucc                                                   20


<210>  10253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10253
auucaucucc accaaagcuu                                                   20


<210>  10254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10254
ucuaagcuuu gcagaugaau                                                   20


<210>  10255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10255
aagcuuugca gaugaauccu                                                   20


<210>  10256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10256
agagaaaaga acagcaacag                                                   20


<210>  10257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10257
ggaggggcug accauuucag                                                   20


<210>  10258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10258
gaggacccac aguccccuuu                                                   20


<210>  10259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10259
gagccuguug cuguucuuuu                                                   20


<210>  10260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10260
uaguacuuua cacuaauaaa                                                   20


<210>  10261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10261
uguucccccg cccacuacgg                                                   20


<210>  10262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10262
aacucuguuu uugaaaaauu                                                   20


<210>  10263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10263
guuuuugaaa aauuuauuuu                                                   20


<210>  10264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10264
uagaagcuaa gaacuuugcc                                                   20


<210>  10265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10265
uguguauaaa aucuuguuua                                                   20


<210>  10266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10266
gcuaccucuu guguauaaaa                                                   20


<210>  10267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10267
gaagguaacu gcacacaccu                                                   20


<210>  10268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10268
auguuagcag ggaagguggg                                                   20


<210>  10269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10269
aguuccuaaa acugacugua                                                   20


<210>  10270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10270
cacggucacu gacaacuaca                                                   20


<210>  10271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10271
aggagaaguc guggugagau                                                   20


<210>  10272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10272
uggaguccuc acacggucac                                                   20


<210>  10273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10273
ccacgacuuc uccuggaguc                                                   20


<210>  10274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10274
cuaagggagc uucuugagaa                                                   20


<210>  10275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10275
cuuagugagg ccgaucuuaa                                                   20


<210>  10276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10276
agaagcuccc uuagugaggc                                                   20


<210>  10277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10277
auaaugcugu guguucucaa                                                   20


<210>  10278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10278
guuugcagac cauuuugaaa                                                   20


<210>  10279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10279
uccaagguaa gccugucaua                                                   20


<210>  10280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10280
cuguaaagcu ucaucaggau                                                   20


<210>  10281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10281
ugauuuuggg cuccugagag                                                   20


<210>  10282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10282
ugagagugca gucgccagcg                                                   20


<210>  10283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10283
ggagcccaaa aucaggagug                                                   20


<210>  10284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10284
caggagccca aaaucaggag                                                   20


<210>  10285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10285
uggugaggau gugggcggag                                                   20


<210>  10286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10286
ccaagagauu gugugggaca                                                   20


<210>  10287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10287
gcccacaucc ucaccaagag                                                   20


<210>  10288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10288
ccgcccacau ccucaccaag                                                   20


<210>  10289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10289
ccuucucucc gcccacaucc                                                   20


<210>  10290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10290
aaaccaaugg uagaacauca                                                   20


<210>  10291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10291
ccucuguccg uuucucuaag                                                   20


<210>  10292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10292
guccguuucu cuaaggguac                                                   20


<210>  10293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10293
aaggguacag uucugcucuu                                                   20


<210>  10294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10294
uaagugcugg cccuuccauc                                                   20


<210>  10295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10295
guguguuuga caaaggccac                                                   20


<210>  10296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10296
agcaagucac agaauaacaa                                                   20


<210>  10297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10297
cugccagaga augaaaagac                                                   20


<210>  10298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10298
ggcagugagg guuucugugc                                                   20


<210>  10299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10299
ccauggccca gucuuuucau                                                   20


<210>  10300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10300
cgccauggcc cagucuuuuc                                                   20


<210>  10301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10301
uuacugugcu cucgccaugg                                                   20


<210>  10302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10302
gugacuuggc aaaucugaca                                                   20


<210>  10303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10303
cuaguucugu gcauggugag                                                   20


<210>  10304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10304
ccaugcacag aacuagggag                                                   20


<210>  10305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10305
cauuuucggc ccuguuuugc                                                   20


<210>  10306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10306
cccccacacc auaaaaggga                                                   20


<210>  10307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10307
cccacaccau aaaagggagc                                                   20


<210>  10308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10308
cuuuuauggu gugggggaga                                                   20


<210>  10309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10309
uuuauaccag cucccuuuua                                                   20


<210>  10310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10310
acaugacuaa uuaacacuga                                                   20


<210>  10311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10311
ucaacaugac uaauuaacac                                                   20


<210>  10312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10312
aauuccuucu cugcauuaca                                                   20


<210>  10313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10313
gcauuacaau aacuaugaaa                                                   20


<210>  10314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10314
caagcagugu guaccaacuc                                                   20


<210>  10315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10315
aauaguuaac uucauauaca                                                   20


<210>  10316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10316
aagcauuaaa aagauaauuc                                                   20


<210>  10317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10317
guaaaauuau aucuuaaagu                                                   20


<210>  10318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10318
uaacuucuuu aaguaauuga                                                   20


<210>  10319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10319
agaaguacag ggugcauuau                                                   20


<210>  10320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10320
uuucaaucua auuauaucag                                                   20


<210>  10321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10321
ugaagauauu uuucugauau                                                   20


<210>  10322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10322
ucuagaccca ucugaaauuc                                                   20


<210>  10323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10323
cuauuuguau agaauuucag                                                   20


<210>  10324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10324
acgaugcuac aaaagaaauu                                                   20


<210>  10325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10325
cucuuguaug uucguguaac                                                   20


<210>  10326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10326
uguauguucg uguaacaaaa                                                   20


<210>  10327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10327
auuuccgaaa aucuccacag                                                   20


<210>  10328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10328
acagaaaugu gaauccacau                                                   20


<210>  10329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10329
cgggacagcu gauccacaug                                                   20


<210>  10330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10330
ggcaugugga ucagcugucc                                                   20


<210>  10331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10331
cacugccaaa cagcucccaa                                                   20


<210>  10332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10332
caaaccuucu aguggcuuaa                                                   20


<210>  10333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10333
aggaaagcau uuuuaagcca                                                   20


<210>  10334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10334
aggcucuucc aaaggguucg                                                   20


<210>  10335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10335
uccaaagggu ucgagauucu                                                   20


<210>  10336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10336
aacccuuugg aagagccugg                                                   20


<210>  10337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10337
gcaccuucuu ggaaucagaa                                                   20


<210>  10338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10338
ucucaggcug ggcauguucc                                                   20


<210>  10339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10339
caggcugggc auguuccucu                                                   20


<210>  10340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10340
ggcugggcau guuccucuag                                                   20


<210>  10341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10341
agggaucaac aucaucaagg                                                   20


<210>  10342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10342
acucaccaau caucauggga                                                   20


<210>  10343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10343
ccaaucauca ugggagauuc                                                   20


<210>  10344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10344
caugaugauu ggugaguuga                                                   20


<210>  10345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10345
aaccguauga acuuuaacuu                                                   20


<210>  10346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10346
uuuagucagu gaaacaaccc                                                   20


<210>  10347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10347
gcacccaugu gagaacgcag                                                   20


<210>  10348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10348
caugggugca gaguagcauu                                                   20


<210>  10349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10349
gcguucucac augggugcag                                                   20


<210>  10350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10350
cagcuuuauc acugcucugc                                                   20


<210>  10351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10351
cccagcuuua ucacugcucu                                                   20


<210>  10352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10352
cacagugccc aacgugaagc                                                   20


<210>  10353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10353
cugcccugca ccugccaaau                                                   20


<210>  10354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10354
gggucacucc ugggucugaa                                                   20


<210>  10355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10355
ugggucugaa ggcuaccucu                                                   20


<210>  10356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10356
guuaccaucu guguggccuu                                                   20


<210>  10357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10357
ccgugugcca uggggcugau                                                   20


<210>  10358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10358
aacuagauca gccccauggc                                                   20


<210>  10359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10359
ccaccccagc uccaacuaga                                                   20


<210>  10360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10360
uccccacccc agcuccaacu                                                   20


<210>  10361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10361
cuaaagugac aaccuaagcu                                                   20


<210>  10362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10362
aaagugacaa ccuaagcuga                                                   20


<210>  10363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10363
gcuuagguug ucacuuuaga                                                   20


<210>  10364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10364
cucagcuuag guugucacuu                                                   20


<210>  10365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10365
cacucagcuu agguugucac                                                   20


<210>  10366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10366
cccccaacuc ucacucagcu                                                   20


<210>  10367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10367
gggccccccu acucaccccc                                                   20


<210>  10368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10368
uccuuccacc ucagggcccc                                                   20


<210>  10369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10369
cuuccuucca ccucagggcc                                                   20


<210>  10370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10370
caaguagcug ggauuacagg                                                   20


<210>  10371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10371
gccucccaag uagcugggau                                                   20


<210>  10372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10372
uugccucagc cucccaagua                                                   20


<210>  10373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10373
cagguuccag cgauucuccu                                                   20


<210>  10374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10374
uucucccagg uuccagcgau                                                   20


<210>  10375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10375
cugcuaccuc cuucucccag                                                   20


<210>  10376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10376
ccucacugcu accuccuucu                                                   20


<210>  10377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10377
agccugggug acagagcaac                                                   20


<210>  10378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10378
gucacccagg cuggagugca                                                   20


<210>  10379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10379
aucucaaaaa aaaaaaaaaa                                                   20


<210>  10380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10380
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  10381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10381
ccacccccau uuucugauuu                                                   20


<210>  10382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10382
acacaguccu gcuugaucua                                                   20


<210>  10383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10383
ucauacaaag ccuuugaaag                                                   20


<210>  10384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10384
uacaaagccu uugaaagguu                                                   20


<210>  10385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10385
gguucaugca cuaaaaccuu                                                   20


<210>  10386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10386
cugguucaug cacuaaaacc                                                   20


<210>  10387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10387
accccugcuu cucucugguu                                                   20


<210>  10388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10388
ccuccacccc ugcuucucuc                                                   20


<210>  10389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10389
gccuacaucu guaaggaucc                                                   20


<210>  10390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10390
cugccuacau cuguaaggau                                                   20


<210>  10391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10391
accugucauc agccccucuc                                                   20


<210>  10392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10392
uccaccuguc aucagccccu                                                   20


<210>  10393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10393
ccuccaccug ucaucagccc                                                   20


<210>  10394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10394
ucccucuccu ccaccuguca                                                   20


<210>  10395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10395
cuuugaaagg gugcucgucc                                                   20


<210>  10396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10396
cacacagcac ccccauguca                                                   20


<210>  10397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10397
gucaguguuc cuuaucucac                                                   20


<210>  10398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10398
cugcgcccac caaagcuggc                                                   20


<210>  10399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10399
ucccugcgcc caccaaagcu                                                   20


<210>  10400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10400
augugcccag ccccuccucc                                                   20


<210>  10401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10401
gacucgaugu gcccagcccc                                                   20


<210>  10402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10402
acuuggcaua ccuuaaagac                                                   20


<210>  10403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10403
uguucuugac guucuccacu                                                   20


<210>  10404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10404
cuuguucuug acguucucca                                                   20


<210>  10405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10405
gcacccaccu uggauuucug                                                   20


<210>  10406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10406
ccgcacccac cuuggauuuc                                                   20


<210>  10407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10407
auauucucuc cgcacccacc                                                   20


<210>  10408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10408
cuccauauuc ucuccgcacc                                                   20


<210>  10409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10409
ugcccucacu ccauauucuc                                                   20


<210>  10410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10410
aaccuguauc cuccugcccu                                                   20


<210>  10411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10411
acaaaccuuu acuggugguc                                                   20


<210>  10412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10412
ucuggaccac caguaaaggu                                                   20


<210>  10413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10413
uuccuaguac ugccucuucu                                                   20


<210>  10414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10414
gucuccuucc uaguacugcc                                                   20


<210>  10415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10415
aacccuucug gcuguuccuu                                                   20


<210>  10416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10416
uaguuuuccu caaacccuuc                                                   20


<210>  10417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10417
cguaguuuuc cucaaacccu                                                   20


<210>  10418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10418
cucguaguuu uccucaaacc                                                   20


<210>  10419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10419
ucccguuuga aacacuauuc                                                   20


<210>  10420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10420
uggcgcucuu cccguuugaa                                                   20


<210>  10421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10421
gcagcaucua gcgcuccugg                                                   20


<210>  10422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10422
ucuuagccga cugcucggca                                                   20


<210>  10423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10423
gcaguugggg ugacaggugg                                                   20


<210>  10424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10424
aacucagcag uuggggugac                                                   20


<210>  10425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10425
ccaacucagc aguuggggug                                                   20


<210>  10426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10426
ucucuccaac ucagcaguug                                                   20


<210>  10427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10427
cucuucucuc caacucagca                                                   20


<210>  10428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10428
ucccugcuaa cucccucuuc                                                   20


<210>  10429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10429
ucagccucuu cccugcuaac                                                   20


<210>  10430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10430
cucuucagcc ucuucccugc                                                   20


<210>  10431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10431
cucgcucuuc agccucuucc                                                   20


<210>  10432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10432
cacucgcucu ucagccucuu                                                   20


<210>  10433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10433
aaacuuaacu uuccccauuu                                                   20


<210>  10434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10434
ucuuugcagc caaacuucga                                                   20


<210>  10435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10435
cuguugcccc ugccuucuuu                                                   20


<210>  10436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10436
ucucccuguu gccccugccu                                                   20


<210>  10437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10437
cuucucccug uugccccugc                                                   20


<210>  10438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10438
ucugcccugu caaagccucu                                                   20


<210>  10439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10439
cuucugcccu gucaaagccu                                                   20


<210>  10440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10440
ucugcccugu caaagccucu                                                   20


<210>  10441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10441
gcacacuggu uucucuucug                                                   20


<210>  10442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10442
acccugccag acccuuccca                                                   20


<210>  10443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10443
ucaauaucca gaacgcucca                                                   20


<210>  10444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10444
gccaaggugg gcggggauga                                                   20


<210>  10445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10445
uccccgccca ccuuggcaga                                                   20


<210>  10446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10446
guccacccaa agccccuagc                                                   20


<210>  10447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10447
ugugacagug ggaaguuugc                                                   20


<210>  10448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10448
ccugugacag ugggaaguuu                                                   20


<210>  10449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10449
ucuccuguga cagugggaag                                                   20


<210>  10450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10450
ugcggccacu aauucccaag                                                   20


<210>  10451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10451
ccugugacag cuuuuauuuu                                                   20


<210>  10452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10452
ugugacagcu uuuauuuucu                                                   20


<210>  10453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10453
gcaaaugaag uaggugauga                                                   20


<210>  10454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10454
ucaccuacuu cauuugcaga                                                   20


<210>  10455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10455
acacauuacc ucaucaccua                                                   20


<210>  10456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10456
cauagugcuu augaggaucc                                                   20


<210>  10457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10457
uaagcacuau gugaggcagc                                                   20


<210>  10458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10458
guggucccuu cacaguacuu                                                   20


<210>  10459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10459
ucuguggucc cuucacagua                                                   20


<210>  10460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10460
ccuggcaagc agguauacuu                                                   20


<210>  10461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10461
ugaaguauac cugcuugcca                                                   20


<210>  10462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10462
cgugcucuug aaguauaccu                                                   20


<210>  10463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10463
ugaaagaaaa gcucccgugc                                                   20


<210>  10464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10464
ccagccuucc uggaaaugug                                                   20


<210>  10465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10465
caccagccuu ccuggaaaug                                                   20


<210>  10466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10466
uuugcucuca ccagccuucc                                                   20


<210>  10467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10467
aggccuucca uucacuucac                                                   20


<210>  10468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10468
agguguuugu ggcuggccac                                                   20


<210>  10469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10469
gcccuguaaa cacacgguua                                                   20


<210>  10470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10470
gcauaugcac uaaccgugug                                                   20


<210>  10471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10471
gcucagcaua ugcacuaacc                                                   20


<210>  10472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10472
agugaucuca gcucagcaua                                                   20


<210>  10473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10473
uuggacucac auuccagagg                                                   20


<210>  10474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10474
cauuccagag gaagcaucuu                                                   20


<210>  10475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10475
ggaaugugag uccaaagagu                                                   20


<210>  10476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10476
gcuguggaaa uucuuuuugg                                                   20


<210>  10477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10477
uaagcuuucc aaaaagaauu                                                   20


<210>  10478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10478
guucucauug gcaggacuac                                                   20


<210>  10479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10479
uuggcaggac uacucuccga                                                   20


<210>  10480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10480
ccgacccauu acugcuuccu                                                   20


<210>  10481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10481
gacccauuac ugcuuccuga                                                   20


<210>  10482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10482
uuuucauuca acaaagcugu                                                   20


<210>  10483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10483
ggucccacug aaggucagau                                                   20


<210>  10484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10484
ggccuccggu cccacugaag                                                   20


<210>  10485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10485
caggccuccg gucccacuga                                                   20


<210>  10486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10486
cucucaggcc uccgguccca                                                   20


<210>  10487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10487
accccugucc cuuuuuguga                                                   20


<210>  10488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10488
ucuucaacuc auaccucucu                                                   20


<210>  10489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10489
uaccucucuu cucagagguu                                                   20


<210>  10490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10490
cuucucagag guugcaguuu                                                   20


<210>  10491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10491
ucucagaggu ugcaguuucu                                                   20


<210>  10492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10492
gagguugcag uuucugagaa                                                   20


<210>  10493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10493
gagaagagag guaugaguug                                                   20


<210>  10494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10494
gaaacugcaa ccucugagaa                                                   20


<210>  10495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10495
auaagugauu uagaccacgc                                                   20


<210>  10496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10496
uguuuuugcg uggucuaaau                                                   20


<210>  10497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10497
caccugagcu gaaaugguuc                                                   20


<210>  10498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10498
ccugagcuga aaugguucgc                                                   20


<210>  10499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10499
ggugagaguu gucucuuguu                                                   20


<210>  10500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10500
aaugaaacau caacuggaaa                                                   20


<210>  10501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10501
guggugucca guaauguucu                                                   20


<210>  10502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10502
gaugucagaa cauuacugga                                                   20


<210>  10503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10503
gauggcauuu uugaccuuuc                                                   20


<210>  10504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10504
auaucuaaug guagaaacug                                                   20


<210>  10505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10505
gucaaguauu gcuucuuaua                                                   20


<210>  10506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10506
auauucaguu cuagagauuu                                                   20


<210>  10507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10507
agaacugaau auggagacug                                                   20


<210>  10508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10508
agugguggga auucuccuug                                                   20


<210>  10509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10509
uugaaguacu ccuuagcugc                                                   20


<210>  10510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10510
uuagcugcag gacaccugau                                                   20


<210>  10511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10511
gucaucaggu guccugcagc                                                   20


<210>  10512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10512
ucggucauca gguguccugc                                                   20


<210>  10513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10513
aggaacccca uuuaaguaga                                                   20


<210>  10514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10514
augaauuuga cuacucuagg                                                   20


<210>  10515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10515
cuucccccag ccccuggggg                                                   20


<210>  10516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10516
cuauuccucc cuucccccag                                                   20


<210>  10517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10517
ggaccuauug aagacugacu                                                   20


<210>  10518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10518
uuucaucuuc ugaaacugaa                                                   20


<210>  10519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10519
agaacucuuu ucaucuucug                                                   20


<210>  10520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10520
augacucuag gcaugucacu                                                   20


<210>  10521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10521
aggcauguca cuuaaacuac                                                   20


<210>  10522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10522
caacuguacu aaccucauga                                                   20


<210>  10523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10523
ugaaguuguu acaaagauga                                                   20


<210>  10524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10524
ggagcuacag gugacaugau                                                   20


<210>  10525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10525
ugagcacuug ugaacccagg                                                   20


<210>  10526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10526
gaauagccuu ucaaaucaug                                                   20


<210>  10527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10527
aggucccuaa ccucagaaua                                                   20


<210>  10528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10528
ucaggcucua ggucccuaac                                                   20


<210>  10529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10529
uuaauguaac ccagcuacca                                                   20


<210>  10530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10530
agguuucuca uuaauguaac                                                   20


<210>  10531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10531
ugaacucuug cucuuaaagc                                                   20


<210>  10532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10532
ugcucuuaaa gccuccauau                                                   20


<210>  10533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10533
uaaagccucc auaucugccc                                                   20


<210>  10534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10534
auaucugccc ugauuccugc                                                   20


<210>  10535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10535
cccaucaggc cuuaugucag                                                   20


<210>  10536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10536
uuuaauacuu ccccucauau                                                   20


<210>  10537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10537
uauuuuuuug agaucaugca                                                   20


<210>  10538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10538
aaaaaauaug aggggaagua                                                   20


<210>  10539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10539
gucagggccu gcuugcuugg                                                   20


<210>  10540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10540
agguaucaaa accgggcaca                                                   20


<210>  10541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10541
uaugugacuu guaauuaaaa                                                   20


<210>  10542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10542
cugcauuuua auucaauacu                                                   20


<210>  10543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10543
aaaguaagua uugaauuaaa                                                   20


<210>  10544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10544
ugcucaaaag uaaguauuga                                                   20


<210>  10545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10545
gcuuugaugc accacaguaa                                                   20


<210>  10546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10546
ucccucagcu uugaugcacc                                                   20


<210>  10547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10547
acugaaaaug gcuccaagug                                                   20


<210>  10548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10548
aagugacaac aagcucucuu                                                   20


<210>  10549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10549
cuuguucuaa aaaucgacaa                                                   20


<210>  10550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10550
uguucuaaaa aucgacaaac                                                   20


<210>  10551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10551
acagaauccc uaaauucuaa                                                   20


<210>  10552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10552
uaaaagucaa acuugcagca                                                   20


<210>  10553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10553
aggugaauaa ucaggcagua                                                   20


<210>  10554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10554
guaauaugau auguggaaaa                                                   20


<210>  10555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10555
caguaauaug auauguggaa                                                   20


<210>  10556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10556
auguuuuagg gauuuaaaca                                                   20


<210>  10557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10557
cgccuguaau cccugcacuu                                                   20


<210>  10558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10558
caaagugcag ggauuacagg                                                   20


<210>  10559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10559
agugauccac ccgccuuugc                                                   20


<210>  10560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10560
ugaccucaag ugauccaccc                                                   20


<210>  10561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10561
aacuccugac cucaagugau                                                   20


<210>  10562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10562
ggcuggucuc aaacuccuga                                                   20


<210>  10563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10563
acaaaaaaau acaaaaauua                                                   20


<210>  10564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10564
caaguaggug ggauuauggg                                                   20


<210>  10565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10565
gccucccaag uaggugggau                                                   20


<210>  10566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10566
caccucagcc ucccaaguag                                                   20


<210>  10567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10567
agugauccuc ccaccucagc                                                   20


<210>  10568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10568
gccccacaag cucaagugau                                                   20


<210>  10569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10569
cugcaaacuc ugccccacaa                                                   20


<210>  10570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10570
gcucacugca aacucugccc                                                   20


<210>  10571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10571
agacuggaag acaaagugag                                                   20


<210>  10572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10572
cuuugucuuc cagucuagag                                                   20


<210>  10573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10573
aaaauaaaua aauaaauaaa                                                   20


<210>  10574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10574
ugaggaguuu auaguuuuua                                                   20


<210>  10575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10575
agagcaggac caaguauuau                                                   20


<210>  10576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10576
ucaagagcag gaccaaguau                                                   20


<210>  10577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10577
gacuagagua cagcguucca                                                   20


<210>  10578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10578
agucagagcc acacacaggc                                                   20


<210>  10579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10579
uaauacauag caaaaucuaa                                                   20


<210>  10580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10580
ggaaagccaa uuuagccuuc                                                   20


<210>  10581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10581
uaaguuguuu gggcagggcu                                                   20


<210>  10582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10582
ugaaauguga augucuuuuu                                                   20


<210>  10583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10583
gguuuugguu uuucucuccc                                                   20


<210>  10584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10584
ccccaguggc uacagaguag                                                   20


<210>  10585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10585
ccaguggcua cagaguagaa                                                   20


<210>  10586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10586
guagccacug gggagagaaa                                                   20


<210>  10587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10587
cugaugcaag aaauuuuuca                                                   20


<210>  10588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10588
cagcaccccu gaaucuugcc                                                   20


<210>  10589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10589
uuuagucagg aagguguagc                                                   20


<210>  10590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10590
ucuuuuaguc aggaaggugu                                                   20


<210>  10591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10591
cccuacacau uucuccucuu                                                   20


<210>  10592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10592
uucuggucag aaaaauuaaa                                                   20


<210>  10593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10593
cucauucugg ucagaaaaau                                                   20


<210>  10594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10594
gugggaucua cagugacuga                                                   20


<210>  10595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10595
cggugggauc uacagugacu                                                   20


<210>  10596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10596
ugcuacucuc ggugggaucu                                                   20


<210>  10597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10597
aacacaaauu ugacucgcuc                                                   20


<210>  10598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10598
cucuacuugu auaggaucuu                                                   20


<210>  10599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10599
acuuguauag gaucuucaau                                                   20


<210>  10600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10600
uggguagaau uauaaagaaa                                                   20


<210>  10601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10601
ugccuguuau cucagcacuu                                                   20


<210>  10602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10602
gcacuuugca aggccaaggc                                                   20


<210>  10603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10603
ugccuuggcc uugcaaagug                                                   20


<210>  10604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10604
agugauccuc cugccuuggc                                                   20


<210>  10605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10605
uggccucaag ugauccuccu                                                   20


<210>  10606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10606
aaaaaauaaa aaaagaaauu                                                   20


<210>  10607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10607
uguauagcug ggacuacagg                                                   20


<210>  10608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10608
gccuccugua uagcugggac                                                   20


<210>  10609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10609
aaguccuagg cacaaaugau                                                   20


<210>  10610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10610
cuguagccuc aaaguccuag                                                   20


<210>  10611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10611
agccugggca acagagggag                                                   20


<210>  10612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10612
guugcccagg cuggagccac                                                   20


<210>  10613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10613
cucuguugcc caggcuggag                                                   20


<210>  10614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10614
gucuugaaaa aaagaaaaca                                                   20


<210>  10615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10615
aauauaucuu aaaacuaaga                                                   20


<210>  10616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10616
uaguuuuaag auauauuuga                                                   20


<210>  10617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10617
guggguuaug aggacauaua                                                   20


<210>  10618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10618
uaacccacag agaacuauag                                                   20


<210>  10619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10619
uauccuuagg aucauaaagu                                                   20


<210>  10620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10620
aacuugcuua guaaaaaugu                                                   20


<210>  10621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10621
uuagggauag gacuguguau                                                   20


<210>  10622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10622
aaacucuuua uuaaaugauu                                                   20


<210>  10623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10623
uuauuaaaug auuauucugu                                                   20


<210>  10624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10624
auggaguauc aagaauucga                                                   20


<210>  10625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10625
auagaggccu uggcacagaa                                                   20


<210>  10626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10626
cucucuaagg aaccucugaa                                                   20


<210>  10627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10627
cuaaggaacc ucugaaccac                                                   20


<210>  10628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10628
aaggaaccuc ugaaccacac                                                   20


<210>  10629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10629
gaaccacacu cauuaacuca                                                   20


<210>  10630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10630
uuaacucaua accagucacc                                                   20


<210>  10631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10631
uaaccaguca ccaaauucca                                                   20


<210>  10632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10632
uuccacaaua ccucuugauc                                                   20


<210>  10633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10633
ugaucugucu gucccuugcc                                                   20


<210>  10634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10634
gaauauuccc agacuccuaa                                                   20


<210>  10635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10635
uaaauggucu ucuaguuccc                                                   20


<210>  10636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10636
auccuucaau acaacugcca                                                   20


<210>  10637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10637
ggcaguugua uugaaggaug                                                   20


<210>  10638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10638
ucacacuucu gagaguggaa                                                   20


<210>  10639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10639
gaagugugaa gagcagggga                                                   20


<210>  10640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10640
cagaagugug aagagcaggg                                                   20


<210>  10641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10641
uaaaaauauu uuucauagua                                                   20


<210>  10642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10642
gagggugacu gugaaguuua                                                   20


<210>  10643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10643
gagguacauu ucuggcuuua                                                   20


<210>  10644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10644
acuguaggcc cuggcagggg                                                   20


<210>  10645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10645
ccuucagucc ccugcacuac                                                   20


<210>  10646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10646
cucacucaac ugugagcucc                                                   20


<210>  10647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10647
cucaacugug agcuccuagg                                                   20


<210>  10648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10648
acugugagcu ccuaggaggu                                                   20


<210>  10649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10649
caguugagug agggagcaag                                                   20


<210>  10650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10650
uaggagguag uuuuauuacu                                                   20


<210>  10651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10651
uaggagcuca caguugagug                                                   20


<210>  10652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10652
ccucuaaacc aaaugcauua                                                   20


<210>  10653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10653
aaaccaaaug cauuagacac                                                   20


<210>  10654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10654
auaaaugcag accaaaugaa                                                   20


<210>  10655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10655
auucauuugg ucugcauuua                                                   20


<210>  10656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10656
cuuuuauuua ggaauguauu                                                   20


<210>  10657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10657
ugagguggag ccguuucuag                                                   20


<210>  10658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10658
ugaguuaaag aauacguucc                                                   20


<210>  10659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10659
accucaugag uuaaagaaua                                                   20


<210>  10660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10660
aucaccuucu ggccgacccu                                                   20


<210>  10661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10661
aaugcuaagu cugggaacug                                                   20


<210>  10662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10662
aagguucuuc cagcugcaac                                                   20


<210>  10663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10663
gauacuuuac uaugaaauua                                                   20


<210>  10664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10664
uuccuaauuu cauaguaaag                                                   20


<210>  10665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10665
uucuuuucuu uucuccuucc                                                   20


<210>  10666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10666
ccuacucuuu cuuuucuuuu                                                   20


<210>  10667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10667
accagcaucu ucuggaaaac                                                   20


<210>  10668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10668
gaguuaagga ugcuaugaac                                                   20


<210>  10669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10669
gaguauuccc auuuguauuc                                                   20


<210>  10670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10670
uucagccauu uuaauaaaau                                                   20


<210>  10671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10671
uggaagugug guauuuuaac                                                   20


<210>  10672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10672
cuuaguacug uaccuggccu                                                   20


<210>  10673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10673
cugaauccuc acaaccugug                                                   20


<210>  10674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10674
caaccuguga agucagucau                                                   20


<210>  10675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10675
augacugacu ucacagguug                                                   20


<210>  10676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10676
uugcuauuua cuaauuauau                                                   20


<210>  10677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10677
cuuugcuauu uacuaauuau                                                   20


<210>  10678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10678
ucugauauag gucuguagag                                                   20


<210>  10679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10679
gauauagguc uguagagaaa                                                   20


<210>  10680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10680
acagaccuau aucagaggag                                                   20


<210>  10681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10681
gccuuuucuc uacagaccua                                                   20


<210>  10682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10682
uauuauaaua uguuuugccc                                                   20


<210>  10683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10683
uuauaugaau uuccacuaug                                                   20


<210>  10684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10684
cgcuacccca gggaccaaca                                                   20


<210>  10685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10685
ggucucauuu cuuauuuauu                                                   20


<210>  10686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10686
uuucuuauuu auuuauuuau                                                   20


<210>  10687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10687
uuucuaugcu uaaauuuuuc                                                   20


<210>  10688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10688
uugggaaaaa uuuaagcaua                                                   20


<210>  10689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10689
cuuugggaaa aauuuaagca                                                   20


<210>  10690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10690
guuuuauuca uuuuuaaucu                                                   20


<210>  10691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10691
uagccuaagu uguuuuuccu                                                   20


<210>  10692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10692
aaggcaguau gcuuguucuc                                                   20


<210>  10693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10693
ccuagagucu cacuuaaagg                                                   20


<210>  10694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10694
uagagucuca cuuaaaggcu                                                   20


<210>  10695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10695
aggagagcau cuuuuugcuc                                                   20


<210>  10696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10696
cuuaaaggcu aucuggcuau                                                   20


<210>  10697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10697
uuuaacugag gucuuaccuu                                                   20


<210>  10698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10698
guuaaacgag ugauagccag                                                   20


<210>  10699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10699
uuacagaaac agcaguacac                                                   20


<210>  10700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10700
augagugcca agagcgagcc                                                   20


<210>  10701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10701
uugagauggu aguguacugc                                                   20


<210>  10702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10702
uggcacucau ugagauggua                                                   20


<210>  10703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10703
cucuuggcac ucauugagau                                                   20


<210>  10704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10704
cgcaaagcaa acauuaccug                                                   20


<210>  10705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10705
ugucacaguu aacacuccau                                                   20


<210>  10706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10706
aucuguuguu gcugccuuua                                                   20


<210>  10707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10707
ugaaaaagug cacauuugca                                                   20


<210>  10708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10708
cacaauuaaa auaaucacca                                                   20


<210>  10709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10709
aucuuccagu ccuucuuccc                                                   20


<210>  10710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10710
gcuggaaggg gaagguugga                                                   20


<210>  10711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10711
auccaaccuu ccccuuccag                                                   20


<210>  10712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10712
uccucaaucc aaccuucccc                                                   20


<210>  10713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10713
aucauggugc cuguguggcu                                                   20


<210>  10714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10714
ccaucauggu gccugugugg                                                   20


<210>  10715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10715
gcucuccauc auggugccug                                                   20


<210>  10716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10716
cagcucucca ucauggugcc                                                   20


<210>  10717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10717
ugagguuuaa caacacacgu                                                   20


<210>  10718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10718
ggaguguggg ugggcugcuc                                                   20


<210>  10719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10719
gaaccacgug uguuguuaaa                                                   20


<210>  10720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10720
uuuguguguu ccugguccug                                                   20


<210>  10721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10721
acaauuaacg aaaugauuuu                                                   20


<210>  10722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10722
cucuggggcc cugaugggua                                                   20


<210>  10723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10723
ggggcccuga uggguagcug                                                   20


<210>  10724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10724
agguccagcc cagccagcua                                                   20


<210>  10725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10725
uccacuaauu auuucuuuuu                                                   20


<210>  10726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10726
ucaugccaaa cauaacucgu                                                   20


<210>  10727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10727
uaacaaaaag caauuuuccu                                                   20


<210>  10728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10728
aacaggaggg aaaaaaaugg                                                   20


<210>  10729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10729
uguuugagga aaauugcuuu                                                   20


<210>  10730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10730
aacagguaag guuucccuuc                                                   20


<210>  10731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10731
ucauggaggg gcaacagagg                                                   20


<210>  10732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10732
uggaggggca acagagggcu                                                   20


<210>  10733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10733
augaggaggu agaagccuug                                                   20


<210>  10734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10734
guugccccuc caugaggagg                                                   20


<210>  10735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10735
agcccucugu ugccccucca                                                   20


<210>  10736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10736
cucaagcccu cuguugcccc                                                   20


<210>  10737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10737
uggcauauuu aagcaacgac                                                   20


<210>  10738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10738
uaaagcuccu ggcauauuua                                                   20


<210>  10739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10739
ccugguguua cuccacaaaa                                                   20


<210>  10740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10740
acaaaauaca cauccauaag                                                   20


<210>  10741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10741
uucaagacuc gcacacacac                                                   20


<210>  10742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10742
cacacacacu gaguacucuc                                                   20


<210>  10743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10743
gugugugugc gagucuugaa                                                   20


<210>  10744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10744
cacagaguac ucacacacug                                                   20


<210>  10745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10745
cagaguacuc acacacugag                                                   20


<210>  10746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10746
gugagaguac ucagugugug                                                   20


<210>  10747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10747
cacacugagu acucacacac                                                   20


<210>  10748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10748
gugugugagu acucugugag                                                   20


<210>  10749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10749
cacacugagu acucgcagag                                                   20


<210>  10750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10750
gugugugagu acucagugug                                                   20


<210>  10751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10751
cagaguacuu gcacacacag                                                   20


<210>  10752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10752
gcgaguacuc agugugugag                                                   20


<210>  10753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10753
cacacagagu acucgugcac                                                   20


<210>  10754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10754
gugugugagu acugugugug                                                   20


<210>  10755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10755
ugcacacuga gcacucacac                                                   20


<210>  10756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10756
gugugcacga guacucugug                                                   20


<210>  10757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10757
cacacaguac ucgcacacac                                                   20


<210>  10758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10758
cacacacaga gaacucgcac                                                   20


<210>  10759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10759
gugugugcga guacugugug                                                   20


<210>  10760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10760
cacacagagu acucgcacac                                                   20


<210>  10761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10761
gugugcgagu ucucugugug                                                   20


<210>  10762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10762
cacacacacu gaguacucac                                                   20


<210>  10763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10763
gugugugugc gaguacucug                                                   20


<210>  10764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10764
caaacacacu gaguacucac                                                   20


<210>  10765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10765
guguguuugu gaguacucag                                                   20


<210>  10766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10766
cacagcggau cccucacagu                                                   20


<210>  10767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10767
cagucuaggg gggauaccua                                                   20


<210>  10768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10768
auaaucuuuc aaagagguaa                                                   20


<210>  10769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10769
uugaaagauu auggaguggg                                                   20


<210>  10770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10770
acuguaucuu caguggcagc                                                   20


<210>  10771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10771
aacaacuguu cucaaauaau                                                   20


<210>  10772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10772
aauaauggcu aacaccaccu                                                   20


<210>  10773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10773
uucuauaugg guugauucug                                                   20


<210>  10774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10774
caaaauuagg uagcuuuguc                                                   20


<210>  10775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10775
ucuaaaaaga caaagcuacc                                                   20


<210>  10776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10776
aacucaucua aaaagacaaa                                                   20


<210>  10777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10777
gccuuauaac acaaccaccu                                                   20


<210>  10778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10778
ggugguugug uuauaaggca                                                   20


<210>  10779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10779
aaugucccuu uagagaguca                                                   20


<210>  10780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10780
aaagggacau uggaggaaca                                                   20


<210>  10781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10781
cuaaagggac auuggaggaa                                                   20


<210>  10782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10782
aucagaagga ugcucugugu                                                   20


<210>  10783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10783
guguuuuuau uuaguuuccu                                                   20


<210>  10784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10784
gacccagaag cuacuaggaa                                                   20


<210>  10785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10785
acaaggucau acagcuaguu                                                   20


<210>  10786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10786
ucauagguuu guuacgggga                                                   20


<210>  10787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10787
uagguuuguu acggggauca                                                   20


<210>  10788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10788
uccugggucu ugucaugaua                                                   20


<210>  10789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10789
cagaacuaau aacacaguca                                                   20


<210>  10790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10790
uuaucucauu auaccugggg                                                   20


<210>  10791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10791
uuauaccugg ggaauuaugu                                                   20


<210>  10792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10792
aaacauaauu ccccagguau                                                   20


<210>  10793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10793
uaguuucgug aaccugaccg                                                   20


<210>  10794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10794
agcccacacc auggcuauuu                                                   20


<210>  10795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10795
uuuaucaccu uaauuugaac                                                   20


<210>  10796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10796
gaauuagcuu uuaauccuaa                                                   20


<210>  10797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10797
uuaggauuaa aagcuaauuc                                                   20


<210>  10798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10798
caccucuccc aaaugaauga                                                   20


<210>  10799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10799
ccucucccaa augaaugaug                                                   20


<210>  10800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10800
cccaaaugaa ugaugacuca                                                   20


<210>  10801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10801
caaaugaaug augacucacu                                                   20


<210>  10802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10802
cuuucucuua uggcaaacua                                                   20


<210>  10803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10803
uauggcaaac uaguaaaaua                                                   20


<210>  10804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10804
acuagcaagu agucgaauga                                                   20


<210>  10805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10805
uucgacuacu ugcuaguuga                                                   20


<210>  10806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10806
uguuucucau ucgacuacuu                                                   20


<210>  10807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10807
ccaagcuaga caaauucagu                                                   20


<210>  10808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10808
aagcuagaca aauucaguau                                                   20


<210>  10809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10809
ucauucuaag auauguuaag                                                   20


<210>  10810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10810
ucccaaagga auguugguaa                                                   20


<210>  10811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10811
ugcuugugcu gaacuccauc                                                   20


<210>  10812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10812
aucgacguau cugucaucag                                                   20


<210>  10813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10813
ucauauuauu ucugacgaca                                                   20


<210>  10814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10814
gugcuugaca gaagagguca                                                   20


<210>  10815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10815
ucugucaagc acugagaaau                                                   20


<210>  10816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10816
aaggguuaua uuaacucaua                                                   20


<210>  10817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10817
uauucuaaaa ccagucccuu                                                   20


<210>  10818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10818
guaccuacag ugaauccaua                                                   20


<210>  10819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10819
guauaauggg aaaaacucug                                                   20


<210>  10820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10820
gaggcuggag aucugcaggu                                                   20


<210>  10821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10821
gaguuuuucc cauuauacug                                                   20


<210>  10822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10822
agccucagag uuuuucccau                                                   20


<210>  10823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10823
accacucacu gugccgcgua                                                   20


<210>  10824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10824
cugugccgcg uaaugugagu                                                   20


<210>  10825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10825
cauuacgcgg cacagugagu                                                   20


<210>  10826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10826
cucacauuac gcggcacagu                                                   20


<210>  10827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10827
agauacuguu guggugaaga                                                   20


<210>  10828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10828
gccaguacau gaagaacuca                                                   20


<210>  10829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10829
cuauucugcc uacuuuguga                                                   20


<210>  10830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10830
aaaucacaaa guaggcagaa                                                   20


<210>  10831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10831
acaaaugcaa aauaguauua                                                   20


<210>  10832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10832
uccauaucca aggccccauu                                                   20


<210>  10833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10833
guguguggau acuauguuga                                                   20


<210>  10834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10834
uuaguguuaa aaaaacaagu                                                   20


<210>  10835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10835
gcuuucucuu uaguguuaaa                                                   20


<210>  10836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10836
cagcuuucuc uuuaguguua                                                   20


<210>  10837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10837
cuuagcagga aaggaaaaau                                                   20


<210>  10838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10838
ggcuuugaca ccagcagagc                                                   20


<210>  10839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10839
gcugguguca aagccagagu                                                   20


<210>  10840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10840
accaaugcau uagcuuugug                                                   20


<210>  10841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10841
gagcuuuacu ccuugccuga                                                   20


<210>  10842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10842
gagauguuaa guaaguuguc                                                   20


<210>  10843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10843
uugccugaga auggggauga                                                   20


<210>  10844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10844
ggcaaggagu aaagcucaga                                                   20


<210>  10845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10845
caguucauca aaauuaagca                                                   20


<210>  10846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10846
auaaauagua cuuauuacca                                                   20


<210>  10847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10847
cauccaucgu auuucuuuua                                                   20


<210>  10848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10848
uguuugaaau ugcuuuauug                                                   20


<210>  10849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10849
ccuguuugaa auugcuuuau                                                   20


<210>  10850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10850
guaagccgag gugggcagau                                                   20


<210>  10851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10851
gcuuaccgag guuguuuugu                                                   20


<210>  10852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10852
agugaucugc ccaccucggc                                                   20


<210>  10853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10853
ugggcucaag ugaucugccc                                                   20


<210>  10854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10854
aacuccuggg cucaagugau                                                   20


<210>  10855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10855
gcccccuggu agcugggacu                                                   20


<210>  10856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10856
ucagcccccu gguagcuggg                                                   20


<210>  10857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10857
cuccucagcc cccugguagc                                                   20


<210>  10858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10858
aaucugggug acagcaaacc                                                   20


<210>  10859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10859
gucaccaggu uugcugucac                                                   20


<210>  10860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10860
cucugucacc agguuugcug                                                   20


<210>  10861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10861
aacagacaac aaacaaaaaa                                                   20


<210>  10862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10862
uguucaaaug aaaaggaagu                                                   20


<210>  10863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10863
ggggcuguga acaaggcugu                                                   20


<210>  10864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10864
cuggggcugu gaacaaggcu                                                   20


<210>  10865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10865
ccagucagaa uccaccuuuc                                                   20


<210>  10866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10866
uaugacuuug ucacuaguua                                                   20


<210>  10867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10867
aaagaauuuu caagucucua                                                   20


<210>  10868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10868
augguacuac uacuuagacu                                                   20


<210>  10869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10869
uaggggccag ucggcaaaac                                                   20


<210>  10870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10870
gcggcacaug aucagcuucc                                                   20


<210>  10871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10871
gaagaagauc uccagcccua                                                   20


<210>  10872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10872
agcccuaauu ccuugcuguc                                                   20


<210>  10873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10873
auaucuugug acagcaagga                                                   20


<210>  10874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10874
uuaaaacuuu ccauuuagcu                                                   20


<210>  10875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10875
ugagccucac auugcuucac                                                   20


<210>  10876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10876
ggaguuuuuu uaauuagauu                                                   20


<210>  10877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10877
cauugcuuca caauaacuac                                                   20


<210>  10878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10878
uugauagcag uagaagucug                                                   20


<210>  10879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10879
ucagaauucu uacaaguaau                                                   20


<210>  10880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10880
aaaaaauuuu uagacuggau                                                   20


<210>  10881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10881
guacuuuuuc cuguucaaca                                                   20


<210>  10882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10882
guuggacaaa gacgucccag                                                   20


<210>  10883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10883
aguaacugau gaaggcuuuu                                                   20


<210>  10884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10884
aaccaguuaa aaagccuuca                                                   20


<210>  10885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10885
aauuaauccu guuauaaaug                                                   20


<210>  10886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10886
gauucagaug gacuuaugcu                                                   20


<210>  10887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10887
ucaaagcaua aguccaucug                                                   20


<210>  10888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10888
ggaagguaaa auggauaauu                                                   20


<210>  10889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10889
gaaaucuagg aacugaaacu                                                   20


<210>  10890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10890
gcgguagaau ugaugcccuu                                                   20


<210>  10891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10891
agagccagua ucucucuguc                                                   20


<210>  10892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10892
ggagaaaaug ugacucagcg                                                   20


<210>  10893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10893
cugucucuua aaaaaaggug                                                   20


<210>  10894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10894
gucucuuaaa aaaagguggg                                                   20


<210>  10895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10895
uaaaaaaagg ugggguguuu                                                   20


<210>  10896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10896
cuccacuacg uuacuucuuc                                                   20


<210>  10897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10897
acuacguuac uucuucacau                                                   20


<210>  10898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10898
aucggcuugg uuuccagccc                                                   20


<210>  10899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10899
gccgugaacu uacuugagag                                                   20


<210>  10900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10900
aguaaguuca cggcugaguc                                                   20


<210>  10901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10901
caaguaaguu cacggcugag                                                   20


<210>  10902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10902
uggaaagcuu ugaaaaacau                                                   20


<210>  10903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10903
caccccaacu guuuuuggac                                                   20


<210>  10904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10904
cauuaguucg uuuccucuga                                                   20


<210>  10905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10905
uuaguucguu uccucugaag                                                   20


<210>  10906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10906
gaagauggua uucauacuuc                                                   20


<210>  10907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10907
ugccacccac uuuaucuugu                                                   20


<210>  10908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10908
ccccguaaau ggaaauggug                                                   20


<210>  10909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10909
gugaauucug ucugaugccc                                                   20


<210>  10910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10910
uucugccgcc ugcuguccug                                                   20


<210>  10911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10911
aaaggcagga cagcaggcgg                                                   20


<210>  10912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10912
agggaggcug cacuaacucu                                                   20


<210>  10913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10913
cuagagaugg ggucaggccg                                                   20


<210>  10914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10914
gccuuuaucc uuuguuuggg                                                   20


<210>  10915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10915
aaguugcaca gcaaagccaa                                                   20


<210>  10916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10916
augaacuaaa uacagauucu                                                   20


<210>  10917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10917
agcuaauguu uauaagaagc                                                   20


<210>  10918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10918
cuuuucagag uccuuucuca                                                   20


<210>  10919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10919
agaaacacuc ccuuuucaga                                                   20


<210>  10920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10920
cuagaaacac ucccuuuuca                                                   20


<210>  10921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10921
uucuuauuac cugcaauuua                                                   20


<210>  10922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10922
uuuuuaaaac guuauuuaua                                                   20


<210>  10923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10923
agaauggugg ccacagcaac                                                   20


<210>  10924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10924
uacuucucuc acauugcacu                                                   20


<210>  10925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10925
cacauugcac uccaguaaga                                                   20


<210>  10926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10926
cauugcacuc caguaagaaa                                                   20


<210>  10927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10927
aguaagaaaa uccugaaaga                                                   20


<210>  10928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10928
uucuuucagg auuuucuuac                                                   20


<210>  10929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10929
gaaguauuuu aaauugcaga                                                   20


<210>  10930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10930
cugaaguauu uuaaauugca                                                   20


<210>  10931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10931
uauuuuagua acuuuaaaca                                                   20


<210>  10932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10932
ucacuaucaa uugcuaugau                                                   20


<210>  10933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10933
aucaggaaga auguagaagu                                                   20


<210>  10934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10934
agaaucccag ugaauuacuu                                                   20


<210>  10935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10935
aaucuauuuc auucagcaac                                                   20


<210>  10936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10936
ucuugugguc acugaauacu                                                   20


<210>  10937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10937
ggcaaguauu cagugaccac                                                   20


<210>  10938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10938
aaaaucaucu caggcaagua                                                   20


<210>  10939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10939
cuguuucagu gaagagaguu                                                   20


<210>  10940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10940
aaaucacugg aagagacaca                                                   20


<210>  10941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10941
uccagugauu uagagcugaa                                                   20


<210>  10942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10942
aacacuuacu uuaucaauuc                                                   20


<210>  10943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10943
uccuucagaa cuaauaaaau                                                   20


<210>  10944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10944
uaacauugcu guaucugcuu                                                   20


<210>  10945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10945
uuacacaugg cccacuauuu                                                   20


<210>  10946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10946
ugcucuuuac acauggccca                                                   20


<210>  10947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10947
ucaucgguuu uuaucuucag                                                   20


<210>  10948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10948
cgccuguaau cucugcacuu                                                   20


<210>  10949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10949
gccuuagaaa cuuuacagac                                                   20


<210>  10950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10950
cuguugcuaa aaauauugga                                                   20


<210>  10951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10951
aauauuuuua gcaacaggga                                                   20


<210>  10952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10952
ggacauacuu cccuguucaa                                                   20


<210>  10953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10953
uuaucuggau augauuuugc                                                   20


<210>  10954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10954
gucacaacag auuaucaaaa                                                   20


<210>  10955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10955
ccugaguuuc uucuuugucc                                                   20


<210>  10956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10956
ggugagaagu gauauguuuu                                                   20


<210>  10957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10957
ccuuugccau gcaaggauaa                                                   20


<210>  10958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10958
uagacuaaau uaaagcaucc                                                   20


<210>  10959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10959
cuuagacuaa auuaaagcau                                                   20


<210>  10960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10960
uucauguuuc ccucucuuag                                                   20


<210>  10961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10961
caaaacaguu guuagaccgc                                                   20


<210>  10962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10962
aaacaguugu uagaccgcag                                                   20


<210>  10963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10963
acaaagacca auauccauug                                                   20


<210>  10964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10964
ugucaaugga uauuggucuu                                                   20


<210>  10965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10965
auucuucaua aacuugaggu                                                   20


<210>  10966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10966
aguuuaugaa gaauagagau                                                   20


<210>  10967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10967
ucucucacca ucuacaaaag                                                   20


<210>  10968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10968
caccaucuac aaaagaagau                                                   20


<210>  10969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10969
ccaucuacaa aagaagauua                                                   20


<210>  10970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10970
aguuuugaac uuuuaaaaga                                                   20


<210>  10971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10971
uuuaaaaguu caaaacuuga                                                   20


<210>  10972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10972
ucuuuuaaaa guucaaaacu                                                   20


<210>  10973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10973
ccucuuuuaa aaguucaaaa                                                   20


<210>  10974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10974
cuccucuuuu aaaaguucaa                                                   20


<210>  10975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10975
guccagacuu uauacacuaa                                                   20


<210>  10976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10976
uuuuuuggau ggaaaaacag                                                   20


<210>  10977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10977
aauauaccag guaagaacca                                                   20


<210>  10978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10978
acaaacaguc cuuucuucuc                                                   20


<210>  10979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10979
ccuuuuuuaa ccagcuuggu                                                   20


<210>  10980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10980
gccccauagg ccgaacaaug                                                   20


<210>  10981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10981
gucauccccu cggccccaua                                                   20


<210>  10982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10982
aucuucacca gaaauuucac                                                   20


<210>  10983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10983
uaggucagcu ccaucuucac                                                   20


<210>  10984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10984
gucuaguaua aaguggcuau                                                   20


<210>  10985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10985
caacuaauua gaaaguauug                                                   20


<210>  10986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10986
uaugccacuu aaguaaaaau                                                   20


<210>  10987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10987
caauaauaug aaggaagaau                                                   20


<210>  10988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10988
aagauaaguu uauuucacug                                                   20


<210>  10989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10989
aagucgugua agaacaaagu                                                   20


<210>  10990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10990
caugaaaaag uaaacacuuu                                                   20


<210>  10991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10991
uccauguaau uugcugugug                                                   20


<210>  10992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10992
guaagugucu cuuccaugua                                                   20


<210>  10993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10993
cuguaagugu cucuuccaug                                                   20


<210>  10994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10994
cucuguaagu gucucuucca                                                   20


<210>  10995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10995
gcuuccugcc guacaacgcu                                                   20


<210>  10996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10996
acuuuucuuu gguaauacug                                                   20


<210>  10997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10997
ccaguauuac caaagaaaag                                                   20


<210>  10998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10998
aaagacacuc acauuuuacu                                                   20


<210>  10999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  10999
cacuuggaag ugauauaggu                                                   20


<210>  11000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11000
cuuggaagug auauaggugg                                                   20


<210>  11001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11001
aauuagucac accucuacau                                                   20


<210>  11002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11002
acauaaguga aaaggaaauc                                                   20


<210>  11003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11003
cugaugcuca uuucauccuu                                                   20


<210>  11004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11004
gaugcucauu ucauccuuuu                                                   20


<210>  11005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11005
uuucauccuu uuaacuuacu                                                   20


<210>  11006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11006
uccaaagcau ucauacucca                                                   20


<210>  11007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11007
aaagcauuca uacuccaggg                                                   20


<210>  11008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11008
agggucucgu cauuuagguc                                                   20


<210>  11009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11009
ucauuuaggu caaauucuuc                                                   20


<210>  11010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11010
agaacccaga gaucagacaa                                                   20


<210>  11011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11011
ggguucuaga ggguguggaa                                                   20


<210>  11012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11012
ucauccuuag cauugaucuc                                                   20


<210>  11013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11013
uccuuagcau ugaucucaau                                                   20


<210>  11014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11014
cuuucugccc uccccugcuc                                                   20


<210>  11015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11015
ggaaacucuu accgccuguc                                                   20


<210>  11016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11016
uaccgccugu ccuuaaugaa                                                   20


<210>  11017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11017
cagaaaacua ugaacuuguc                                                   20


<210>  11018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11018
accgcccuga uccacacuuc                                                   20


<210>  11019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11019
ccaagauucu ucuucugaag                                                   20


<210>  11020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11020
auguuuagca uccagggaaa                                                   20


<210>  11021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11021
auuaaauaug augaacaaau                                                   20


<210>  11022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11022
uuaggugaau uaccaagacg                                                   20


<210>  11023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11023
aaagaaaaaa aaaaggaaaa                                                   20


<210>  11024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11024
uuuuccuuuu uuuuuucuuu                                                   20


<210>  11025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11025
auggagaaaa uaaaacagca                                                   20


<210>  11026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11026
ucuaacaaau ugguccaaag                                                   20


<210>  11027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11027
aacaaauugg uccaaagaaa                                                   20


<210>  11028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11028
gacaagaagu cacuccuaga                                                   20


<210>  11029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11029
uagauugaga gccaugaaag                                                   20


<210>  11030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11030
aucuaggagu gacuucuugu                                                   20


<210>  11031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11031
caaucuagga gugacuucuu                                                   20


<210>  11032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11032
uaucugauua ggaaauaaca                                                   20


<210>  11033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11033
ucaauuauca uaauaccuaa                                                   20


<210>  11034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11034
uucuggaagu agaaagcaaa                                                   20


<210>  11035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11035
cugucaacag aucuauaagu                                                   20


<210>  11036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11036
cccugucaac agaucuauaa                                                   20


<210>  11037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11037
cucccuguca acagaucuau                                                   20


<210>  11038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11038
uaacaaaugc aaaauuuaca                                                   20


<210>  11039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11039
ccugugagga cagucuuuac                                                   20


<210>  11040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11040
caggugagug aagauaucac                                                   20


<210>  11041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11041
gaucagaaga ucuguaaaga                                                   20


<210>  11042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11042
ccccauuuuc uguuggaaug                                                   20


<210>  11043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11043
ccauuuucug uuggaaugaa                                                   20


<210>  11044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11044
ugaacuuaug aguauacaga                                                   20


<210>  11045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11045
uaaguucagg aggcaucacu                                                   20


<210>  11046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11046
gccaaaaagu acaaaaauua                                                   20


<210>  11047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11047
ggaggcugag gugcaagaau                                                   20


<210>  11048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11048
cgaguagcug ggaucacagg                                                   20


<210>  11049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11049
gccucccgag uagcugggau                                                   20


<210>  11050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11050
uguaccugga agguagaggu                                                   20


<210>  11051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11051
aacucuaauu auaguaugag                                                   20


<210>  11052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11052
cucaaacucu aauuauagua                                                   20


<210>  11053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11053
aacucccuca aacucuaauu                                                   20


<210>  11054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11054
agguaguaaa aguuguacuu                                                   20


<210>  11055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11055
uugaucagau ggaugaauac                                                   20


<210>  11056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11056
cacauaaagu ucuuuauucc                                                   20


<210>  11057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11057
cauaaaguuc uuuauuccac                                                   20


<210>  11058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11058
uucauguucc cuuucuacca                                                   20


<210>  11059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11059
ucuuaauuau uuugaauauu                                                   20


<210>  11060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11060
acauucuaau gauuugaaac                                                   20


<210>  11061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11061
agaguuacug ggugaaauac                                                   20


<210>  11062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11062
ugagauuuaa agauguuaaa                                                   20


<210>  11063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11063
gguacauagu acugcagcuu                                                   20


<210>  11064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11064
uuggacauuu aauggaaagc                                                   20


<210>  11065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11065
cuuuggacau uuaauggaaa                                                   20


<210>  11066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11066
acaggaaaua agcguagccc                                                   20


<210>  11067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11067
caaaaccacu gaccauauua                                                   20


<210>  11068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11068
aaaccacuga ccauauuauu                                                   20


<210>  11069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11069
ugguagaccc uauauauuuc                                                   20


<210>  11070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11070
aaaguuguuu uuaaauuaua                                                   20


<210>  11071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11071
ugaaaugugu aaagacaugu                                                   20


<210>  11072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11072
gggagcccag guugcauaua                                                   20


<210>  11073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11073
cugaggugau uucuuuuuuc                                                   20


<210>  11074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11074
gccccacaaa cccugaacug                                                   20


<210>  11075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11075
uuuccaguac cuucccccag                                                   20


<210>  11076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11076
cuuuuccagu accuuccccc                                                   20


<210>  11077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11077
gcuguuucua uuccucucuu                                                   20


<210>  11078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11078
ucugcuguuu cuauuccucu                                                   20


<210>  11079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11079
gcagaugcug auauaauuau                                                   20


<210>  11080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11080
uauuguaauu ccuuuuagag                                                   20


<210>  11081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11081
aaaaggaauu acaauaugag                                                   20


<210>  11082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11082
auuaugcuga uauaauuuuu                                                   20


<210>  11083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11083
guaaaaagua gcauuccaac                                                   20


<210>  11084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11084
cccucuuuaa uuaaaaggau                                                   20


<210>  11085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11085
cucuuuaauu aaaaggauac                                                   20


<210>  11086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11086
uuaauuaaaa ggauacuauu                                                   20


<210>  11087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11087
aauauacuga auauauuaug                                                   20


<210>  11088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11088
uugguaagag cagggucagg                                                   20


<210>  11089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11089
uaccaaggag uuugauguag                                                   20


<210>  11090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11090
uuaaacuaaa ucaacaguug                                                   20


<210>  11091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11091
ucuacuuuca uuucaacugu                                                   20


<210>  11092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11092
aauuccucaa acauacuuaa                                                   20


<210>  11093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11093
aacauacuua agucaggucu                                                   20


<210>  11094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11094
guaaugcaag guuagcauug                                                   20


<210>  11095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11095
uuucugugua uccuuccuaa                                                   20


<210>  11096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11096
gagugaaaca cuuagggaau                                                   20


<210>  11097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11097
gagguuggcu auccucuuuu                                                   20


<210>  11098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11098
uaagcccccu uaaaugccuc                                                   20


<210>  11099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11099
gugccuggug ucgugcuggu                                                   20


<210>  11100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11100
auggccauug uccucagugc                                                   20


<210>  11101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11101
cuauucuuuu cuuacugucc                                                   20


<210>  11102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11102
uuucagaagu aaugcuauuu                                                   20


<210>  11103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11103
uucuuccuug aagguuuugg                                                   20


<210>  11104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11104
ccauuguacu gaaugguguu                                                   20


<210>  11105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11105
uuagcaaaau cuguuuuagg                                                   20


<210>  11106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11106
acuuaaaguu gccucauuag                                                   20


<210>  11107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11107
uaggauucca caaaauacug                                                   20


<210>  11108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11108
auuaacucug guuuucauga                                                   20


<210>  11109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11109
ugaaaaccag aguuaauuga                                                   20


<210>  11110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11110
aaaucuaacu aacuuuguuc                                                   20


<210>  11111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11111
gccucuucuu ccuaccucca                                                   20


<210>  11112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11112
ucuuccuacc uccaagagua                                                   20


<210>  11113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11113
uugaguggua uuuauacucu                                                   20


<210>  11114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11114
uuguaauguu gacccuccuu                                                   20


<210>  11115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11115
cagauggaag acaaacucca                                                   20


<210>  11116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11116
aaguuaacaa aaucuuuugg                                                   20


<210>  11117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11117
agcuggcagu gccgccauca                                                   20


<210>  11118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11118
gaaaaggaag ucaucuaaca                                                   20


<210>  11119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11119
uuaaaccauu guuagaugac                                                   20


<210>  11120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11120
auuccagguu caucacucau                                                   20


<210>  11121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11121
uuucacugua uuguaagccc                                                   20


<210>  11122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11122
cucugguuaa gaaucacucu                                                   20


<210>  11123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11123
cugguuaaga aucacucuuu                                                   20


<210>  11124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11124
gguuaagaau cacucuuuuc                                                   20


<210>  11125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11125
uuucuaugua uccccaguag                                                   20


<210>  11126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11126
uuuauaacac aaaccaagcu                                                   20


<210>  11127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11127
cuuuuauaac acaaaccaag                                                   20


<210>  11128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11128
cucuuuuaua acacaaacca                                                   20


<210>  11129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11129
uaggguacac auguaauuug                                                   20


<210>  11130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11130
uauguacccc accacuggag                                                   20


<210>  11131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11131
aguggugggg uacauaugag                                                   20


<210>  11132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11132
ucagaugaga aucacccuua                                                   20


<210>  11133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11133
ucugaagagg cagccccuaa                                                   20


<210>  11134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11134
guuauugcca guacugugug                                                   20


<210>  11135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11135
aucuuaucac auggcagauu                                                   20


<210>  11136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11136
guggggcaga aaaggaaaug                                                   20


<210>  11137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11137
ucaagacccu ucuuucacuc                                                   20


<210>  11138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11138
cauucagcug uacgauuagg                                                   20


<210>  11139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11139
ucuucaagca ucguagcugg                                                   20


<210>  11140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11140
auuucugaag cuaagaagga                                                   20


<210>  11141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11141
ccuggccuua augauaguuu                                                   20


<210>  11142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11142
caucuguaau cccagcacuu                                                   20


<210>  11143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11143
caaagugcug ggauuacaga                                                   20


<210>  11144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11144
gccucccaaa gugcugggau                                                   20


<210>  11145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11145
ugauccgccc accucagccu                                                   20


<210>  11146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11146
ugccucagcc ucccgaguag                                                   20


<210>  11147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11147
gcuuccuggg uucaagcaau                                                   20


<210>  11148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11148
cugcaaccuc ugcuuccugg                                                   20


<210>  11149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11149
gcucacugca accucugcuu                                                   20


<210>  11150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11150
agacugggca aaagagcaag                                                   20


<210>  11151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11151
uguuuuugac agacacuuac                                                   20


<210>  11152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11152
uucccagcac cuaagucuaa                                                   20


<210>  11153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11153
aaagaagcaa aucucuuucc                                                   20


<210>  11154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11154
gaauuaauuu cugagguucc                                                   20


<210>  11155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11155
uggucuugac guucuuuacc                                                   20


<210>  11156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11156
ucacaaagaa uuugcuucag                                                   20


<210>  11157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11157
gcucuucaca aagaauuugc                                                   20


<210>  11158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11158
ugaucugaac uaaaauuuac                                                   20


<210>  11159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11159
guguaaauuu uaguucagau                                                   20


<210>  11160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11160
uauuuuaauu acacugauac                                                   20


<210>  11161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11161
auucauuaau gacugguuau                                                   20


<210>  11162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11162
ccccuacaua uuagucauuu                                                   20


<210>  11163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11163
ccuacauauu agucauuuac                                                   20


<210>  11164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11164
aaucaaaaua cuccauacac                                                   20


<210>  11165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11165
auacacugag auaacagucu                                                   20


<210>  11166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11166
guguauggag uauuuugauu                                                   20


<210>  11167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11167
uauuaguaac ugaaaccuuu                                                   20


<210>  11168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11168
cuuguuuuau gaauuuguuc                                                   20


<210>  11169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11169
aauuccauau uuuagcaaga                                                   20


<210>  11170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11170
uuacaccguu auuucuguua                                                   20


<210>  11171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11171
cuuuacaccg uuauuucugu                                                   20


<210>  11172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11172
uuaggccagu cugaggauua                                                   20


<210>  11173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11173
gacuggccua augaguuugg                                                   20


<210>  11174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11174
guauauuaga aagugcauga                                                   20


<210>  11175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11175
guuuuagaua uaauauguau                                                   20


<210>  11176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11176
gguuucuuug auccauucuu                                                   20


<210>  11177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11177
uaacacuucu uuugauauuu                                                   20


<210>  11178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11178
ucgauucacu gauuuuuuga                                                   20


<210>  11179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11179
auucacugau uuuuugaagg                                                   20


<210>  11180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11180
aucuucuuca guucugcucu                                                   20


<210>  11181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11181
gaucuuaguu auuuuuugcc                                                   20


<210>  11182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11182
ugcuucucua guucuuuuaa                                                   20


<210>  11183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11183
aguucuuuua auugugaugu                                                   20


<210>  11184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11184
ugugggcauu uagugcuaua                                                   20


<210>  11185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11185
aaacauugcu uuagcugugu                                                   20


<210>  11186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11186
gggacacagc uaaagcaaug                                                   20


<210>  11187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11187
uugguuucaa auaacuuauu                                                   20


<210>  11188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11188
ugaaugacua cuggguaaau                                                   20


<210>  11189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11189
aaaucgcaca acuacaugga                                                   20


<210>  11190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11190
aaaauugacc acauaauugg                                                   20


<210>  11191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11191
accccaaauc aacagaauau                                                   20


<210>  11192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11192
ccaccccaaa ucaacagaau                                                   20


<210>  11193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11193
ggaccaagca gaccuaauag                                                   20


<210>  11194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11194
gcucuggacc aagcagaccu                                                   20


<210>  11195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11195
caagacuaaa ccaagaagaa                                                   20


<210>  11196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11196
auuucagaac uuguuauugg                                                   20


<210>  11197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11197
gguagaauuc agcugugaau                                                   20


<210>  11198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11198
uuguaccucu gguagaauuc                                                   20


<210>  11199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11199
ucuuuguacc ucugguagaa                                                   20


<210>  11200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11200
uuuucuguug cuuggaauag                                                   20


<210>  11201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11201
cuaacucauu uuaugaggac                                                   20


<210>  11202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11202
uuuuaugagg acagcaucuu                                                   20


<210>  11203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11203
cucaucacuc uuauuuaaca                                                   20


<210>  11204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11204
caucacucuu auuuaacaua                                                   20


<210>  11205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11205
ucacucuuau uuaacauagu                                                   20


<210>  11206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11206
uauuuaacau aguauuggaa                                                   20


<210>  11207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11207
ugccugauug cccuggccag                                                   20


<210>  11208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11208
guuugcagau gacaugauug                                                   20


<210>  11209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11209
caggccaaaa ucuccuuaag                                                   20


<210>  11210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11210
ggccaaaauc uccuuaagca                                                   20


<210>  11211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11211
uuaagcaacu ucagcaaagu                                                   20


<210>  11212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11212
ggauacaaaa ucaaugugca                                                   20


<210>  11213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11213
ugauuugucu auuauucgug                                                   20


<210>  11214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11214
cauucacaau uacuacaaag                                                   20


<210>  11215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11215
uuguaguaau ugugaauggg                                                   20


<210>  11216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11216
acaugccuug uaaguuguau                                                   20


<210>  11217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11217
uugaagaagu ccuccacaug                                                   20


<210>  11218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11218
aggaaauaag agaggacaca                                                   20


<210>  11219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11219
uauuuccuug agcagugguu                                                   20


<210>  11220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11220
cuuauuuccu ugagcagugg                                                   20


<210>  11221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11221
ugcccaggaa gaaucaaugu                                                   20


<210>  11222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11222
aauucuguga agaaagucag                                                   20


<210>  11223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11223
agcuuuguuc uuuuugcuua                                                   20


<210>  11224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11224
aaucuuuguu auuucuuucc                                                   20


<210>  11225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11225
uugaaugaaa agaugaacaa                                                   20


<210>  11226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11226
cuuuuuugug uuagucuacc                                                   20


<210>  11227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11227
gaaaugaaag uggguacaua                                                   20


<210>  11228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11228
caacaaagaa aagcccugga                                                   20


<210>  11229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11229
ggcugaaacc uucaauacua                                                   20


<210>  11230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11230
cuuuucaauu uggaugucuu                                                   20


<210>  11231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11231
ugccucagcc ucccgaguag                                                   20


<210>  11232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11232
gcuucccggc uucccggguu                                                   20


<210>  11233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11233
cugcaagcuc cgcuucccgg                                                   20


<210>  11234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11234
gcucacugca agcuccgcuu                                                   20


<210>  11235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11235
gucgcccagg ccggacugcg                                                   20


<210>  11236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11236
cucugucgcc caggccggac                                                   20


<210>  11237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11237
gucucaaaaa aaaaaaaaaa                                                   20


<210>  11238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11238
aaaaaaaaaa aaaaaaaaaa                                                   20


<210>  11239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11239
uuaguuaccu guguuuuuug                                                   20


<210>  11240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11240
aagucaaaag ucaaucacca                                                   20


<210>  11241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11241
guauaagguu agcuuuucca                                                   20


<210>  11242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11242
gauugacucc ucucauaaua                                                   20


<210>  11243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11243
ucucauaaua cuaguuggag                                                   20


<210>  11244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11244
cauaauacua guuggagacc                                                   20


<210>  11245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11245
uaauacuagu uggagaccag                                                   20


<210>  11246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11246
aacuaguauu augagaggag                                                   20


<210>  11247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11247
ggucuccaac uaguauuaug                                                   20


<210>  11248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11248
cuggucucca acuaguauua                                                   20


<210>  11249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11249
gcugccucuc uggucuccaa                                                   20


<210>  11250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11250
cggcucagcu gccucucugg                                                   20


<210>  11251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11251
uagucagaca gacacaucag                                                   20


<210>  11252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11252
acauguugau ucaugucugu                                                   20


<210>  11253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11253
uuugguccug uuguuuugug                                                   20


<210>  11254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11254
gcacuuggug auccgagcag                                                   20


<210>  11255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11255
gaucaccaag ugcugaggua                                                   20


<210>  11256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11256
guucaccaag caaaagccaa                                                   20


<210>  11257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11257
gcaaccaggg uggaccuucu                                                   20


<210>  11258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11258
acucagcaac caggguggac                                                   20


<210>  11259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11259
ucuucuugcu ucugccuugc                                                   20


<210>  11260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11260
ugcuauaguc caaguaggaa                                                   20


<210>  11261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11261
uucagggaaa ggccaaguuu                                                   20


<210>  11262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11262
agcauaccca guugcuggcu                                                   20


<210>  11263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11263
gaagcuguag gcacguaaca                                                   20


<210>  11264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11264
ucuuguuacg ugccuacagc                                                   20


<210>  11265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11265
cccgcaauca gcgagucuuu                                                   20


<210>  11266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11266
cgcaaucagc gagucuuugg                                                   20


<210>  11267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11267
cugauugcgg gagaggcuuu                                                   20


<210>  11268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11268
uucacuucca gagcugcaau                                                   20


<210>  11269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11269
ggaagugaag gagaaccagu                                                   20


<210>  11270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11270
auaauaaagg aaguuuuuaa                                                   20


<210>  11271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11271
auuuuagaaa uaccucaaua                                                   20


<210>  11272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11272
aucucuauuu uagaaauacc                                                   20


<210>  11273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11273
uuaaaauaua gcuuuauuuc                                                   20


<210>  11274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11274
gcuaagcuaa aaacuguuga                                                   20


<210>  11275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11275
guauacacuu aguauuuaug                                                   20


<210>  11276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11276
ugcucacaag caagagaaga                                                   20


<210>  11277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11277
caagcaagag aagagggucu                                                   20


<210>  11278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11278
ugcuugugag caugaguaaa                                                   20


<210>  11279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11279
ucucuugcuu gugagcauga                                                   20


<210>  11280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11280
cauuuuugug acucuggcaa                                                   20


<210>  11281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11281
ggcaaaccua cacacagaau                                                   20


<210>  11282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11282
uuacugucuc uuuuuaauca                                                   20


<210>  11283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11283
uuuuaaucag uaccugaacu                                                   20


<210>  11284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11284
gcaguucagg uacugauuaa                                                   20


<210>  11285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11285
caacaagauc aagccguccu                                                   20


<210>  11286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11286
ugaagcaagc cacaguagaa                                                   20


<210>  11287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11287
uaauacuugu uccauucuuu                                                   20


<210>  11288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11288
uucucauaau acuuguucca                                                   20


<210>  11289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11289
uauucagaau guccuguuua                                                   20


<210>  11290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11290
agcagcaggg augauuuccu                                                   20


<210>  11291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11291
aguugcaaua caaguaagug                                                   20


<210>  11292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11292
acccuaauag aagaccuauc                                                   20


<210>  11293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11293
ccaaagaugg uauagaagca                                                   20


<210>  11294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11294
gaauaagucu agcuguuucu                                                   20


<210>  11295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11295
aucccaucag aaguagacua                                                   20


<210>  11296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11296
cugcaugaca uuuacaacca                                                   20


<210>  11297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11297
gcaugacauu uacaaccaaa                                                   20


<210>  11298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11298
gcuguuuuuc agcauaggaa                                                   20


<210>  11299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11299
cucccuuauc uccuucaggu                                                   20


<210>  11300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11300
cuuaucuccu ucaggucuuu                                                   20


<210>  11301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11301
uucaggucuu ugcuagaugu                                                   20


<210>  11302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11302
gccauuuaca gggcugucaa                                                   20


<210>  11303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11303
uuucacauca cucagccauu                                                   20


<210>  11304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11304
acagugugga acacagaaua                                                   20


<210>  11305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11305
gugccagacc uccccucagg                                                   20


<210>  11306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11306
ccucaggaau uccuucaacc                                                   20


<210>  11307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11307
ggaauuccuu caaccauccu                                                   20


<210>  11308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11308
gcucaugcuu ugagcuggug                                                   20


<210>  11309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11309
ugcuuugagc ugguguccau                                                   20


<210>  11310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11310
aagcaugagc agaggauggu                                                   20


<210>  11311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11311
guugccuggu guucaagcaa                                                   20


<210>  11312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11312
cacucacccu uccuuccauu                                                   20


<210>  11313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11313
cucacccuuc cuuccauucc                                                   20


<210>  11314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11314
cccuuccuuc cauuccagcu                                                   20


<210>  11315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11315
caaaggcaga gauaauaucu                                                   20


<210>  11316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11316
aaggcagaga uaauaucuaa                                                   20


<210>  11317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11317
gccuuugaga ggcagcugau                                                   20


<210>  11318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11318
ugucaguuug aaauaaggug                                                   20


<210>  11319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11319
uggcuucuac ucuucuugaa                                                   20


<210>  11320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11320
ucuugaaaau uucccccacu                                                   20


<210>  11321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11321
uguaacauua cauugaaacu                                                   20


<210>  11322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11322
aaccucaaac cgccagcuuu                                                   20


<210>  11323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11323
aaccgccagc uuugaggaag                                                   20


<210>  11324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11324
aagcuggcgg uuugagguua                                                   20


<210>  11325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11325
ugccaacagc ugaugaugac                                                   20


<210>  11326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11326
aaacucaugc caacagcuga                                                   20


<210>  11327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11327
agaacggaaa gauuuuucuu                                                   20


<210>  11328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11328
ucuugcauuu uuaauauaug                                                   20


<210>  11329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11329
guaaacaacu gcuuauuaag                                                   20


<210>  11330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11330
cauugccuca gucuuaaacu                                                   20


<210>  11331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11331
uugccucagu cuuaaacuag                                                   20


<210>  11332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11332
gucuuaaacu agauguaguu                                                   20


<210>  11333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11333
caaaagcuuu uauuuugcug                                                   20


<210>  11334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11334
gaagucuuaa aaugauacca                                                   20


<210>  11335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11335
uggucugaag aaaauaaagc                                                   20


<210>  11336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11336
acaacuuaga aguaagaaac                                                   20


<210>  11337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11337
gaagguagac auucccgggg                                                   20


<210>  11338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11338
aucccuguca ucaaagcaac                                                   20


<210>  11339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11339
aaaucuccau cccugucauc                                                   20


<210>  11340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11340
guccucaaaa ucuccauccc                                                   20


<210>  11341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11341
uaaacuuaga aaacauugcu                                                   20


<210>  11342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11342
uucucuuaaa cuuagaaaac                                                   20


<210>  11343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11343
uuaauauaag ccacaccaau                                                   20


<210>  11344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11344
aaauacugau aauaaaauua                                                   20


<210>  11345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11345
gaauaaauug auguagaaaa                                                   20


<210>  11346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11346
gacauacgca augaucagau                                                   20


<210>  11347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11347
uugaaucuga ucauugcgua                                                   20


<210>  11348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11348
acugaaucac aacuagaguc                                                   20


<210>  11349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11349
aguugugauu caguugagac                                                   20


<210>  11350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11350
uaccucagcc uccugaguag                                                   20


<210>  11351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11351
gccuccugag uagcugggac                                                   20


<210>  11352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11352
ugaguagcug ggacuacagg                                                   20


<210>  11353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11353
ggaggcugag guaggaggau                                                   20


<210>  11354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11354
uaccuuucuu ccuaaagaau                                                   20


<210>  11355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11355
ugauacccac ugauccagcc                                                   20


<210>  11356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11356
uagaguuauc cugaaguuuu                                                   20


<210>  11357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11357
acgaguacgg aagcuucugc                                                   20


<210>  11358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11358
cugccaagcc ucacaaauau                                                   20


<210>  11359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11359
gccaagccuc acaaauauuu                                                   20


<210>  11360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11360
caaauauuua uauuuaccuu                                                   20


<210>  11361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11361
uccagauugg cgagcugaua                                                   20


<210>  11362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11362
ccaaucugga agagccaagg                                                   20


<210>  11363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11363
uauguaacgu auuugacaug                                                   20


<210>  11364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11364
cguauguaac guauuugaca                                                   20


<210>  11365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11365
cugguguagu gauggcucuc                                                   20


<210>  11366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11366
ugauggaaaa aagcaaaaua                                                   20


<210>  11367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11367
uuuccuaauc aaacuuacaa                                                   20


<210>  11368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11368
auuauauuaa uuacacaugc                                                   20


<210>  11369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11369
ccauuauauu aauuacacau                                                   20


<210>  11370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11370
guggugccua cucuccauua                                                   20


<210>  11371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11371
ccaguagaga acagggggag                                                   20


<210>  11372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11372
acuggggagc agucauuagc                                                   20


<210>  11373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11373
cccuguucuc uacuggggag                                                   20


<210>  11374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11374
uuuaugcagu uauaaccauu                                                   20


<210>  11375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11375
cauuuauccu gaauuuauua                                                   20


<210>  11376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11376
gaaugauauu auagcagcua                                                   20


<210>  11377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11377
ucaaguuuag ugcaaguuga                                                   20


<210>  11378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11378
cuaguaaggu uuaugcucug                                                   20


<210>  11379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11379
aguaagguuu augcucugua                                                   20


<210>  11380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11380
guaaauuaaa aagaugcagu                                                   20


<210>  11381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11381
aucaauauuu caaugacuuc                                                   20


<210>  11382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11382
acaccuaaaa cagugccuag                                                   20


<210>  11383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11383
uaagugucua cuaggcaccc                                                   20


<210>  11384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11384
uugaaacagu ugucugaacu                                                   20


<210>  11385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11385
uuccaaaauc agcaaagcuc                                                   20


<210>  11386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11386
auggcauaug aagaacuaaa                                                   20


<210>  11387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11387
agcagcagca gcaguggggu                                                   20


<210>  11388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11388
cagauggggu cccacugcca                                                   20


<210>  11389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11389
accaacuggg cuuuucugau                                                   20


<210>  11390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11390
auaauuaaga aaccacuuuu                                                   20


<210>  11391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11391
caauaauuaa gaaaccacuu                                                   20


<210>  11392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11392
uccuuuuccu cucaauaauu                                                   20


<210>  11393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11393
uguggauaau auacagauau                                                   20


<210>  11394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11394
ccuguggaua auauacagau                                                   20


<210>  11395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11395
cuaugguuuc auuacuguga                                                   20


<210>  11396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11396
caguaaugaa accauaggga                                                   20


<210>  11397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11397
caacguguuu aauuuuauuu                                                   20


<210>  11398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11398
cacaacgugu uuaauuuuau                                                   20


<210>  11399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11399
acagugaagg uaucuuuggu                                                   20


<210>  11400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11400
uagguaacau uaaggguuaa                                                   20


<210>  11401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11401
uuucauggac aucuuuuaac                                                   20


<210>  11402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11402
uggugccuca uuucauggac                                                   20


<210>  11403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11403
guuccacgaa cuauucuacc                                                   20


<210>  11404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11404
agcgaucuuc ccaccucagc                                                   20


<210>  11405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11405
auagugauca cauagcgcuc                                                   20


<210>  11406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11406
gccagaagca gcaaucucuc                                                   20


<210>  11407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11407
caauuauuac aaguuuagua                                                   20


<210>  11408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11408
auuauuacaa guuuaguaga                                                   20


<210>  11409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11409
uuucauucuu gauaaauuaa                                                   20


<210>  11410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11410
cucauuucau ucuugauaaa                                                   20


<210>  11411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11411
ggcaguucag aacuuuguca                                                   20


<210>  11412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11412
guuaaguaua uuuaauagaa                                                   20


<210>  11413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11413
uuucacuagu uuggaaagaa                                                   20


<210>  11414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11414
guaguccacc aaauaugaaa                                                   20


<210>  11415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11415
uuacuaagug cuuuuuauuc                                                   20


<210>  11416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11416
ugauaagaac acuaacauga                                                   20


<210>  11417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11417
gacuucuuuu uuaaauggca                                                   20


<210>  11418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11418
gcuuucucag acuucuuuuu                                                   20


<210>  11419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11419
uugcuuugau uccccuuuuu                                                   20


<210>  11420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11420
agaauggcua uucuuauuca                                                   20


<210>  11421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11421
acucuagaau ggcuauucuu                                                   20


<210>  11422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11422
augaguaccc aucacuagag                                                   20


<210>  11423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11423
uagagucuuu cucuacucua                                                   20


<210>  11424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11424
agugaugggu acucauagag                                                   20


<210>  11425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11425
gcugcugccc ucuagugaug                                                   20


<210>  11426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11426
cucugcugcu gcccucuagu                                                   20


<210>  11427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11427
cuaccucacu cugcugcugc                                                   20


<210>  11428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11428
cccuaccuca cucugcugcu                                                   20


<210>  11429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11429
gagcacucgc caguuuucug                                                   20


<210>  11430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11430
gagaaggacu ugcucucccu                                                   20


<210>  11431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11431
aucacauugc uguuuuuuga                                                   20


<210>  11432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11432
cuaaaaauua uuuugaaaaa                                                   20


<210>  11433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11433
gggcauuaau aggguaagca                                                   20


<210>  11434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11434
ggugguccug gugaugaccu                                                   20


<210>  11435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11435
uuggaaguuc uguguguagg                                                   20


<210>  11436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11436
uuauagguaa gugaucagaa                                                   20


<210>  11437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11437
guucagucuc cuuauaggua                                                   20


<210>  11438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11438
ggucacagca uguguuagag                                                   20


<210>  11439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11439
aacacaugcu gugaccagag                                                   20


<210>  11440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11440
aucaggguuu cucaaccugg                                                   20


<210>  11441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11441
accuggacuc uagugacauu                                                   20


<210>  11442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11442
agugacauuc uggacaggau                                                   20


<210>  11443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11443
uaagggguau ucgaauacuu                                                   20


<210>  11444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11444
caauuccaau aaguuaagcu                                                   20


<210>  11445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11445
uuuauuucca gcaugacggu                                                   20


<210>  11446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11446
cauguaucuc uuuuauuucc                                                   20


<210>  11447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11447
aagagauguu aaauaaaauu                                                   20


<210>  11448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11448
uugagguaaa ugcuuuuuuu                                                   20


<210>  11449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11449
cuucuaaucu uguguagcaa                                                   20


<210>  11450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11450
uucaggauuc aguaucuuua                                                   20


<210>  11451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11451
ugauguaaca aaauaauuau                                                   20


<210>  11452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11452
ucaguucaau augaauuaag                                                   20


<210>  11453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11453
gcuauaugaa aauaauauua                                                   20


<210>  11454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11454
aaucuagaua guuuggauaa                                                   20


<210>  11455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11455
guugguaagu acguuauucu                                                   20


<210>  11456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11456
uugucuuuuc aaucgaugau                                                   20


<210>  11457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11457
acguaacaca gauaaucaau                                                   20


<210>  11458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11458
acaauacuug uuauuaucug                                                   20


<210>  11459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11459
uauauugcug gugggauuac                                                   20


<210>  11460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11460
uggauguaua ucuagaaguc                                                   20


<210>  11461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11461
aauuuaagaa uuuucuccuu                                                   20


<210>  11462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11462
uugaagagcu gcugcugaac                                                   20


<210>  11463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11463
ucaaggagaa aauucuuaaa                                                   20


<210>  11464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11464
caagaucaug cuguccuuuu                                                   20


<210>  11465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11465
agaucaugcu guccuuuugu                                                   20


<210>  11466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11466
aagcuaaaau gcuuggaauu                                                   20


<210>  11467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11467
cuaucuaauu cacaaacauc                                                   20


<210>  11468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11468
aucuaauuca caaacauccu                                                   20


<210>  11469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11469
cagaucuccu uggcacgauu                                                   20


<210>  11470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11470
uuggcacgau uccagcccag                                                   20


<210>  11471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11471
guaucugggc uggaaucgug                                                   20


<210>  11472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11472
aaauacugca aaaagaaaua                                                   20


<210>  11473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11473
aggcauucau uccuaaaagc                                                   20


<210>  11474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11474
cgguaagugu accggccauc                                                   20


<210>  11475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11475
acacuagugg auggccggua                                                   20


<210>  11476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11476
aggcccggcc acagcagcug                                                   20


<210>  11477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11477
uggcgaaaau aacaaaaaga                                                   20


<210>  11478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11478
uuaccacuuu ucuuuuuguu                                                   20


<210>  11479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11479
uucauaaaac aaaccuauca                                                   20


<210>  11480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11480
cucauucaua aaacaaaccu                                                   20


<210>  11481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11481
augaaauuac ucgcucauuc                                                   20


<210>  11482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11482
gcuuaauaau ccccaguuug                                                   20


<210>  11483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11483
agucaucuca gcuuaauaau                                                   20


<210>  11484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11484
uuauauugac cauuuagagc                                                   20


<210>  11485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11485
aaauggucaa uauaaagagu                                                   20


<210>  11486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11486
augcacucau aauucagucu                                                   20


<210>  11487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11487
uaauucaguc uucaacuucu                                                   20


<210>  11488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11488
uguuugcagu ucuuagcuuu                                                   20


<210>  11489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11489
gaaguugcua auuccuuguu                                                   20


<210>  11490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11490
auuuuacuua ccaugcaguu                                                   20


<210>  11491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11491
uaugaaagug uuuuaacuag                                                   20


<210>  11492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11492
uuauaaagag aacuacuuuu                                                   20


<210>  11493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11493
uuauaaagag uauuacacaa                                                   20


<210>  11494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11494
acaagggucu ucaucuuaca                                                   20


<210>  11495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11495
acaaagacaa caaaagugua                                                   20


<210>  11496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11496
cuauugaaua uguaaaugug                                                   20


<210>  11497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11497
cauuuacaua uucaauagug                                                   20


<210>  11498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11498
uagggaucag ccaauccuca                                                   20


<210>  11499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11499
aucagcaaau acuguauuuc                                                   20


<210>  11500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11500
ccagccacua ggcacaggag                                                   20


<210>  11501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11501
ugugccuagu ggcuggugag                                                   20


<210>  11502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11502
cacuaaagca uuuuccgaag                                                   20


<210>  11503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11503
ugacuucgga aaaugcuuua                                                   20


<210>  11504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11504
uacccuguga agggcuguac                                                   20


<210>  11505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11505
gcacuaaaug ucucucuguc                                                   20


<210>  11506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11506
cuguccuaag cugcaccuua                                                   20


<210>  11507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11507
guccuaagcu gcaccuuauu                                                   20


<210>  11508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11508
ugaaauaagg ugcagcuuag                                                   20


<210>  11509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11509
acuugcuuuu uuucauaauu                                                   20


<210>  11510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11510
uuuguaaaac ucaacuugcu                                                   20


<210>  11511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11511
auauucauca acaugccuca                                                   20


<210>  11512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11512
aaauuauaca gccaaucaua                                                   20


<210>  11513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11513
gauuuaauaa acuugcaaag                                                   20


<210>  11514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11514
caaguaguug accuuuaaua                                                   20


<210>  11515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11515
ucagcaagaa gcaaauauau                                                   20


<210>  11516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11516
ucuccaauua caaugaagau                                                   20


<210>  11517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11517
aauuacaaug aagauaucug                                                   20


<210>  11518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11518
gugacauuau cagauaucuu                                                   20


<210>  11519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11519
acucugugac auuaucagau                                                   20


<210>  11520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11520
acauuagaug aagccuuaga                                                   20


<210>  11521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with CTCN PAM

<400>  11521
aaggcuucau cuaauguuga                                                   20


<210>  11522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11522
caucugaauc aucagaaugu                                                   20


<210>  11523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11523
uagagaaaua aucaaaagga                                                   20


<210>  11524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11524
uccucagcuu ugcgcuugaa                                                   20


<210>  11525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11525
guguuuccca gauggucauc                                                   20


<210>  11526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11526
ucucuguggu aagaauuagg                                                   20


<210>  11527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11527
uugugucauc ucugugguaa                                                   20


<210>  11528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11528
gaaaaaucuc cuacacauaa                                                   20


<210>  11529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11529
gugacaguug acaaggagag                                                   20


<210>  11530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11530
cugacauggg gguuccucag                                                   20


<210>  11531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11531
acugucacug acaugggggu                                                   20


<210>  11532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11532
cuccuuguca acugucacug                                                   20


<210>  11533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11533
ucaaccaugg ugaaacuggg                                                   20


<210>  11534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11534
aacccauucc ugaaucugug                                                   20


<210>  11535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11535
cuuacuugca guaaauggcc                                                   20


<210>  11536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11536
cuuguuucag gagaucacuu                                                   20


<210>  11537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11537
caccuuaaau ugcaaaagau                                                   20


<210>  11538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11538
cccugaagcc aucgugccca                                                   20


<210>  11539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11539
uuguacauac cauuuucucu                                                   20


<210>  11540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11540
aaaugagaga gaaaauggua                                                   20


<210>  11541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11541
ggaaaggcuu ccuugaggaa                                                   20


<210>  11542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11542
ucuucugagc ccugcaaacu                                                   20


<210>  11543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11543
cuaggaaguu ccaaacuuuc                                                   20


<210>  11544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11544
aagccauuca acaagucucu                                                   20


<210>  11545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11545
auauuauuau uagcauuuuu                                                   20


<210>  11546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11546
cagauggaga ugaggaacuu                                                   20


<210>  11547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11547
guuuacuaaa auauagcaag                                                   20


<210>  11548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11548
ccucuugaau gcuuugcugc                                                   20


<210>  11549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11549
gcaugacccg gcugugagac                                                   20


<210>  11550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11550
ugcugacaca agaggugggu                                                   20


<210>  11551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11551
cacagccggg ucaugcugac                                                   20


<210>  11552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11552
aaucuuaaag cuccaaaaug                                                   20


<210>  11553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11553
aaaauccagc agggcaguca                                                   20


<210>  11554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11554
auuuuacacu guugauaaag                                                   20


<210>  11555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11555
uauucaaaua aucauauaaa                                                   20


<210>  11556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11556
caaacuccug ggcucaagug                                                   20


<210>  11557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11557
gucuguaguc ccagcuauca                                                   20


<210>  11558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11558
gaauugauuu aauccuagua                                                   20


<210>  11559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11559
uuuaagucau ugagcucuug                                                   20


<210>  11560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11560
aagagcaccc agcuccacug                                                   20


<210>  11561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11561
caggaaaaaa aaaaaaucaa                                                   20


<210>  11562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11562
ccaccacaua guuugcugug                                                   20


<210>  11563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11563
uuucuccuuu ccagaaacca                                                   20


<210>  11564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11564
gcccugcaca caaugacguc                                                   20


<210>  11565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11565
uccauuaccg caacuccuca                                                   20


<210>  11566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11566
cccugagcau uucggcguca                                                   20


<210>  11567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11567
gaguuuuuaa agauaauuug                                                   20


<210>  11568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11568
gggugguguc agcugaucca                                                   20


<210>  11569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11569
gcugauccau cgagugcagg                                                   20


<210>  11570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11570
gcaaaauauu ucaagcacua                                                   20


<210>  11571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11571
caggaugaga uacgaggucg                                                   20


<210>  11572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11572
gcacaagaua cagguaauaa                                                   20


<210>  11573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11573
ggaaguuacc cuauaugguc                                                   20


<210>  11574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11574
aaaaagggaa ggcaugaaua                                                   20


<210>  11575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11575
uggagagcug aagucaggac                                                   20


<210>  11576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11576
uggugaaugg aggccacagu                                                   20


<210>  11577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11577
aagugcuucc aaaugucaca                                                   20


<210>  11578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11578
caugguuucc ugcaggucua                                                   20


<210>  11579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11579
aggccuuugc aaaaccauaa                                                   20


<210>  11580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11580
cuguccacuu gaugacucag                                                   20


<210>  11581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11581
gguuuuucuu cuuuggagag                                                   20


<210>  11582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11582
cucuccaaag aagaaaaacc                                                   20


<210>  11583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11583
aggaaaagcc aggcucacuu                                                   20


<210>  11584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11584
acuugguuaa gugacuuaac                                                   20


<210>  11585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11585
cucacucucu auugcaucuc                                                   20


<210>  11586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11586
ccuuuuuguu gaacacuuac                                                   20


<210>  11587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11587
ggucuugaag agugaauaag                                                   20


<210>  11588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11588
ugaagaguga auaagaguuc                                                   20


<210>  11589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11589
acuuuuugaa auaagccccu                                                   20


<210>  11590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11590
accuagcaaa uccaaaagca                                                   20


<210>  11591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11591
uauuucuucc uguuuuuauu                                                   20


<210>  11592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11592
acuggcauug auuguauuac                                                   20


<210>  11593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11593
cuuuccucau cucaguggga                                                   20


<210>  11594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11594
accaaggguc uugaguugga                                                   20


<210>  11595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11595
gagauuacac ccagguaccg                                                   20


<210>  11596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11596
gagacuugua auacucuaag                                                   20


<210>  11597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11597
cugaccuuag gugggcacag                                                   20


<210>  11598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11598
cacauuaacc aggcucccuu                                                   20


<210>  11599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11599
ggggaaauuc ggccuuuaaa                                                   20


<210>  11600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11600
cauggcuaag guuccaagcu                                                   20


<210>  11601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11601
uuguauugcu gugagaaaug                                                   20


<210>  11602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11602
uaauuucuuc uuauaacacu                                                   20


<210>  11603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11603
caagauauuu uccuuuuaua                                                   20


<210>  11604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11604
cacuaagaua aaugcauauc                                                   20


<210>  11605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11605
ggaaaggcag gaaaacucaa                                                   20


<210>  11606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11606
caugccuccc uuguuaaaag                                                   20


<210>  11607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11607
aauucagaag uuauccaaaa                                                   20


<210>  11608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11608
ccaauucuuu aucagguuuu                                                   20


<210>  11609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11609
ugauuaaaau aaaauaagaa                                                   20


<210>  11610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11610
cuacuaaaaa uacaaaaauu                                                   20


<210>  11611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11611
gguccgcagg aauuaaugga                                                   20


<210>  11612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11612
gcaggaauua auggagcaca                                                   20


<210>  11613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11613
agcagggucu ccagggcuac                                                   20


<210>  11614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11614
ccagggcuac ucagggagag                                                   20


<210>  11615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11615
gucucugguc ucuuucucuc                                                   20


<210>  11616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11616
cuggucucuu ucucucugug                                                   20


<210>  11617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11617
cuuucucucu gugcaaacug                                                   20


<210>  11618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11618
gaaaaguaaa aagugcaaug                                                   20


<210>  11619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11619
caugaauuaa auaaaaggca                                                   20


<210>  11620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11620
ucaaaaugua aauauguggu                                                   20


<210>  11621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11621
aaauuauguu caaauauuag                                                   20


<210>  11622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11622
uaagcugcuu cuuuggcuuu                                                   20


<210>  11623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11623
accuuugauc uauuugguuu                                                   20


<210>  11624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11624
cccuggugug cuguauucuc                                                   20


<210>  11625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11625
cuugugcuaa gacuuuaagg                                                   20


<210>  11626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11626
uagcacaagu gacuccauuu                                                   20


<210>  11627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11627
guucuagaau cuguguuucc                                                   20


<210>  11628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11628
agaauguuug cuauagagau                                                   20


<210>  11629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11629
cuaggagaga agaaaugaau                                                   20


<210>  11630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11630
uuuuucugua acugcuucau                                                   20


<210>  11631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11631
cucugccucc caugaagauu                                                   20


<210>  11632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11632
ggaggcaggg aauauaaggc                                                   20


<210>  11633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11633
uagcugaagc gugaaucugc                                                   20


<210>  11634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11634
cacauugugg aguguacuuu                                                   20


<210>  11635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11635
auaaaauuuc uucauucuuu                                                   20


<210>  11636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11636
aauucuuugu ucaagaugcc                                                   20


<210>  11637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11637
uuggcaucuu gaacaaagaa                                                   20


<210>  11638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11638
agguccuugg caucuugaac                                                   20


<210>  11639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11639
ucagcccucu gaggcugugc                                                   20


<210>  11640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11640
gugucuucag cccucugagg                                                   20


<210>  11641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11641
ggagcuguag cagccaucgu                                                   20


<210>  11642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11642
gcgugaggau gaaaggccaa                                                   20


<210>  11643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11643
auuugugaau uaucuaaucu                                                   20


<210>  11644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11644
uccauauccc cucuugaagc                                                   20


<210>  11645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11645
aagaagaggg gcugguggug                                                   20


<210>  11646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11646
cagguaucuc cugcucacac                                                   20


<210>  11647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11647
guggagaaug ggggaucucu                                                   20


<210>  11648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11648
cuugcccacu cauccuuccc                                                   20


<210>  11649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11649
agguacccug gcuuucaucc                                                   20


<210>  11650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11650
cuuaaccacu guggcuuccc                                                   20


<210>  11651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11651
ccucucaauc acuguagaag                                                   20


<210>  11652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11652
cucugcaggc uaauggcaga                                                   20


<210>  11653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11653
ggaguaaauc ggcauucagg                                                   20


<210>  11654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11654
ccauacuugg gcaccaucaa                                                   20


<210>  11655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11655
uuucaaguuc ugagacucua                                                   20


<210>  11656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11656
gauguccuuu caaguucuga                                                   20


<210>  11657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11657
caguuucccg aucuguaaaa                                                   20


<210>  11658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11658
ucgcacccuc ccagucucag                                                   20


<210>  11659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11659
cagucaggac cagaaccagc                                                   20


<210>  11660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11660
cucuuggagu ccaggcuguc                                                   20


<210>  11661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11661
aggcugucac cagcccucuc                                                   20


<210>  11662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11662
ccagcccucu ccauccacag                                                   20


<210>  11663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11663
guggauggag agggcuggug                                                   20


<210>  11664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11664
gccagggcua uucugcggcu                                                   20


<210>  11665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11665
guggguaaga aauggauuag                                                   20


<210>  11666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11666
uuuccuuuuu uagagcauaa                                                   20


<210>  11667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11667
ucugaguuua ugcucuaaaa                                                   20


<210>  11668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11668
cccaggcaca gaauuccagg                                                   20


<210>  11669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11669
cuugcagggu ggcuggagcc                                                   20


<210>  11670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11670
gaugcaacuc uggacccaac                                                   20


<210>  11671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11671
agaguugcau cagacuuggu                                                   20


<210>  11672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11672
gcugauuagu aaucuuaauu                                                   20


<210>  11673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11673
aaccuaauca ugggagcccu                                                   20


<210>  11674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11674
cucaugugcu gugcaaucuu                                                   20


<210>  11675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11675
aggucccugu uguacuucag                                                   20


<210>  11676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11676
cuguuguacu ucagauuugc                                                   20


<210>  11677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11677
cguagcaaau cugaaguaca                                                   20


<210>  11678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11678
uguccugugc auuguagguu                                                   20


<210>  11679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11679
ugugcauugu agguugcuac                                                   20


<210>  11680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11680
cccagccgag ccagggaaau                                                   20


<210>  11681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11681
ugagccaagu gacaccuggu                                                   20


<210>  11682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11682
cuuggcucag gacccagccg                                                   20


<210>  11683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11683
cugcacucag gaggucccca                                                   20


<210>  11684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11684
ccauaaacua ggggagauuc                                                   20


<210>  11685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11685
aguuccaggg ccugagcuuc                                                   20


<210>  11686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11686
acuggaugaa gggcagccug                                                   20


<210>  11687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11687
auguccacug gaugaagggc                                                   20


<210>  11688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11688
cccaggaugg cagguuagca                                                   20


<210>  11689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11689
cgcuccuucc auguggaucc                                                   20


<210>  11690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11690
gaggcccggg aggaguuaag                                                   20


<210>  11691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11691
agaggagaaa ccugcuucug                                                   20


<210>  11692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11692
aagagcuagg agaggcuguc                                                   20


<210>  11693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11693
cccaucccca aagucaaaga                                                   20


<210>  11694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11694
ccagcucaaa gccuuuucau                                                   20


<210>  11695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11695
agggggcaag ugccuccugu                                                   20


<210>  11696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11696
uuuggauaua uuguuguugg                                                   20


<210>  11697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11697
cuguaccugu aacuucccau                                                   20


<210>  11698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11698
auuguaccuu ccagucccug                                                   20


<210>  11699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11699
ccaaagccaa uuucuaggcu                                                   20


<210>  11700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11700
gaguuguccc caaagccaau                                                   20


<210>  11701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11701
agauguguga cgggagccac                                                   20


<210>  11702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11702
cacaucugga cacagagaag                                                   20


<210>  11703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11703
ugcaauagcg gaggguggag                                                   20


<210>  11704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11704
gcggcacagu gguucuggug                                                   20


<210>  11705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11705
cggccaccag aaccacugug                                                   20


<210>  11706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11706
gucagcuucg ucugcugcgg                                                   20


<210>  11707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11707
gcuucgucug cugcggugca                                                   20


<210>  11708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11708
gcugcggugc agguggccug                                                   20


<210>  11709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11709
gucaaggcca gcaucccagg                                                   20


<210>  11710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11710
aggccagcau cccagggcca                                                   20


<210>  11711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11711
caucgaggug gcccugggau                                                   20


<210>  11712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11712
cuggagaggu gauagggguc                                                   20


<210>  11713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11713
ucagagaagg agagcugcag                                                   20


<210>  11714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11714
gcagggcggg guguggcagc                                                   20


<210>  11715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11715
ccacccgcug ccacaccccg                                                   20


<210>  11716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11716
uuaaaagcca ugccucucuc                                                   20


<210>  11717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11717
cauaccaagc ugagcucagc                                                   20


<210>  11718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11718
ugcaaucccc cuaagcuuua                                                   20


<210>  11719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11719
uuuucauuuc aaaugaggaa                                                   20


<210>  11720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11720
aggcacagcu gcaccuggca                                                   20


<210>  11721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11721
cugguggugc ccgcuguggg                                                   20


<210>  11722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11722
gaaauaaagc cuuccugggc                                                   20


<210>  11723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11723
guucucugaa uagcacccag                                                   20


<210>  11724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11724
guuuugccca cuguggcacc                                                   20


<210>  11725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11725
cuaaggugac agaagguggu                                                   20


<210>  11726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11726
ccuuagugac cagcugggcc                                                   20


<210>  11727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11727
ccugcuggga uggccccagg                                                   20


<210>  11728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11728
aggucacaca gcaguagaac                                                   20


<210>  11729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11729
cacagcagua gaacccaacu                                                   20


<210>  11730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11730
ugcccucauc ugcaaggaug                                                   20


<210>  11731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11731
ucacccuccu cugagcuccc                                                   20


<210>  11732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11732
cccuggucug ugauugggag                                                   20


<210>  11733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11733
gugauuggga gcagugagcc                                                   20


<210>  11734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11734
gccaagugau uaucucuacu                                                   20


<210>  11735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11735
ugcaggaaca gaagagaggc                                                   20


<210>  11736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11736
accacuuugg ggguccugca                                                   20


<210>  11737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11737
ccgcagaaac ggcaucaaga                                                   20


<210>  11738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11738
cccaggcugg aguacagugg                                                   20


<210>  11739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11739
ugauugagcc acuguacucc                                                   20


<210>  11740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11740
gccauguacc aucuuaguga                                                   20


<210>  11741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11741
cuaagauggu acauggcaga                                                   20


<210>  11742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11742
aagucacuaa gaugguacau                                                   20


<210>  11743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11743
cuucacaccu acaccuccag                                                   20


<210>  11744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11744
caccagcaac ucauuaacuc                                                   20


<210>  11745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11745
uggccccucc ugugggcuuc                                                   20


<210>  11746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11746
ccagcaucau gaaagaggcu                                                   20


<210>  11747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11747
gggcugcaga gggaagacag                                                   20


<210>  11748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11748
ccuucacagu gagggcuucc                                                   20


<210>  11749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11749
ugaagaaggu aagggaggga                                                   20


<210>  11750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11750
ccaaccucac cuccuccauc                                                   20


<210>  11751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11751
gcggguacgu accucagugc                                                   20


<210>  11752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11752
acgcaggcaa ggcgagcgac                                                   20


<210>  11753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11753
aaugggcgug cucuuucccu                                                   20


<210>  11754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11754
ugggagcccg cucgcaagga                                                   20


<210>  11755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11755
agcagagggc gcgcuaaccc                                                   20


<210>  11756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11756
uucaucgucc agcagagggc                                                   20


<210>  11757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11757
ucgcccgcau uucacaggcg                                                   20


<210>  11758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11758
cggcggggag gggagucauc                                                   20


<210>  11759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11759
gcggcugggc ucggacccgg                                                   20


<210>  11760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11760
ugcagggccu cgugggccgc                                                   20


<210>  11761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11761
ccaggccugg ccuccuuggg                                                   20


<210>  11762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11762
ugaucagguu accucaguuu                                                   20


<210>  11763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11763
acccagcuca accccacagu                                                   20


<210>  11764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11764
aagccuuggc uggggcccag                                                   20


<210>  11765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11765
guugaagcga gccgccucca                                                   20


<210>  11766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11766
cuggccugca cacccccggg                                                   20


<210>  11767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11767
gccauggcug ccuggccagu                                                   20


<210>  11768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11768
ucucgucagc cauggcugcc                                                   20


<210>  11769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11769
acggcaccuu cuaugccaug                                                   20


<210>  11770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11770
uggugaucgg gggcaucauc                                                   20


<210>  11771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11771
gcuggggcca ggagggcugg                                                   20


<210>  11772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11772
ugaguucuag uucaaguccu                                                   20


<210>  11773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11773
uguuccaaac ucucuaugac                                                   20


<210>  11774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11774
uagagaguuu ggaacaggac                                                   20


<210>  11775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11775
cccagccucu cuaggcauug                                                   20


<210>  11776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11776
cacagcuggu cagguacaga                                                   20


<210>  11777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11777
gguacagacc cagggagaaa                                                   20


<210>  11778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11778
guaccugacc agcuguguga                                                   20


<210>  11779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11779
uucuguucag ugcuggagcg                                                   20


<210>  11780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11780
gggcugguuu guagucauuu                                                   20


<210>  11781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11781
uuuagcaggc aguuuacagu                                                   20


<210>  11782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11782
acuugccucu gucugugcaa                                                   20


<210>  11783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11783
gugcaauucc uugagcagag                                                   20


<210>  11784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11784
cugggagaag uccuuggggc                                                   20


<210>  11785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11785
uuggggccaa agccacucau                                                   20


<210>  11786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11786
ccacugcuau uauaauccuu                                                   20


<210>  11787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11787
cacuucugug accuuggcag                                                   20


<210>  11788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11788
cagaaguggg acaugaagga                                                   20


<210>  11789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11789
cucccccuca gcucugagcc                                                   20


<210>  11790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11790
uuccccaucu ucucugcuug                                                   20


<210>  11791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11791
uggugagagc ugacagucau                                                   20


<210>  11792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11792
gcucucacca agaccagaga                                                   20


<210>  11793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11793
ucuggaauaa ugcagaauuc                                                   20


<210>  11794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11794
gaaguuccau ccuuaaggcu                                                   20


<210>  11795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11795
auccauauga ugaaauacua                                                   20


<210>  11796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11796
ccucagggaa uuggcaaacc                                                   20


<210>  11797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11797
acugcacaga ggcugucucu                                                   20


<210>  11798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11798
cuccuuugcu ugcagaucac                                                   20


<210>  11799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11799
cugcugacuc ugacuuucaa                                                   20


<210>  11800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11800
gcagggacga aggugaucug                                                   20


<210>  11801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11801
gagucagcag ggacgaaggu                                                   20


<210>  11802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11802
ccccugacug aggagaguga                                                   20


<210>  11803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11803
ggggagacug gccuaugggg                                                   20


<210>  11804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11804
cugggccuca guuuccucau                                                   20


<210>  11805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11805
ugucagggac gagacagugu                                                   20


<210>  11806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11806
gggacgagac aguguuucgg                                                   20


<210>  11807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11807
cugacaagac aaagucccug                                                   20


<210>  11808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11808
cgucccugac aagacaaagu                                                   20


<210>  11809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11809
cuagccccaa accucauggg                                                   20


<210>  11810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11810
ccagccgccc uauguaaggc                                                   20


<210>  11811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11811
uaggcggcuu ccucccacag                                                   20


<210>  11812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11812
ggcaggcucu ggucauaggc                                                   20


<210>  11813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11813
ugagcuacag ugaggaccac                                                   20


<210>  11814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11814
ucacuguagc ucaugacuuu                                                   20


<210>  11815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11815
ccagggccac cuucuccucc                                                   20


<210>  11816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11816
uccacaaggg cucagacgag                                                   20


<210>  11817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11817
gagcccuugu ggaugaccac                                                   20


<210>  11818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11818
uuccccuuca cucucgucug                                                   20


<210>  11819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11819
cacacccucc acugcccucu                                                   20


<210>  11820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11820
gccacaucug ccacaucuca                                                   20


<210>  11821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11821
ggccucaguu caaaccccag                                                   20


<210>  11822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11822
caacccucaa cauuccuggg                                                   20


<210>  11823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11823
cugaaugcuu gucgugagua                                                   20


<210>  11824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11824
ugaguagcag ggggccagga                                                   20


<210>  11825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11825
ucuggcuccu ggcccccugc                                                   20


<210>  11826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11826
gcugcugacc ugcucuguga                                                   20


<210>  11827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11827
gcagcagacc caaauuugaa                                                   20


<210>  11828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11828
cagagcaggu cagcagcaga                                                   20


<210>  11829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11829
guuugugaac ugagcuccuu                                                   20


<210>  11830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11830
aaugagggag gcaaagacac                                                   20


<210>  11831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11831
uugccucccu cauuggacuc                                                   20


<210>  11832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11832
ccgggugucu uugccucccu                                                   20


<210>  11833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11833
cucaucuacu ucuccaauua                                                   20


<210>  11834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11834
ugcagcuagc ggcuggaaug                                                   20


<210>  11835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11835
acauuccagc cgcuagcugc                                                   20


<210>  11836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11836
gaaugccugg guccacauuc                                                   20


<210>  11837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11837
uugucccugc agcccccugg                                                   20


<210>  11838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11838
cugcagcccc cuggccuguc                                                   20


<210>  11839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11839
ccagggcccu gcccccuugg                                                   20


<210>  11840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11840
ucuuggaagg aagccaaggg                                                   20


<210>  11841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11841
aggucaucuu ggaaggaagc                                                   20


<210>  11842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11842
auguccaggu caucuuggaa                                                   20


<210>  11843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11843
uguggagaug cauuggggcu                                                   20


<210>  11844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11844
agcgggcacc ugcagcccug                                                   20


<210>  11845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11845
uggaagcggu ccagcgggca                                                   20


<210>  11846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11846
uuggguaccg cugccaguug                                                   20


<210>  11847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11847
gaagccuccu ucuccuccac                                                   20


<210>  11848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11848
uccucuuccu ucucagguuc                                                   20


<210>  11849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11849
ccggcuccau cuggcagccc                                                   20


<210>  11850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11850
gggaggaggu ccccggcucc                                                   20


<210>  11851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11851
ggcucaaaac ccagcuccuu                                                   20


<210>  11852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11852
ggaacugcug cugaccccug                                                   20


<210>  11853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11853
uuggccaacc uuugaaggca                                                   20


<210>  11854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11854
gcuuuggggg aagguggaaa                                                   20


<210>  11855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11855
ugguuugagg uaguguuacu                                                   20


<210>  11856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11856
gagaccuuca ccugggcuau                                                   20


<210>  11857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11857
cugacuccca gguggcccag                                                   20


<210>  11858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11858
uggccuaggg aaggagaugc                                                   20


<210>  11859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11859
uggcccuggg aacacacuuc                                                   20


<210>  11860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11860
uuucugccuc ugcagugaag                                                   20


<210>  11861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11861
ugacucagga caggaguucc                                                   20


<210>  11862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11862
ugacagcaga gaggguguac                                                   20


<210>  11863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11863
ugagucauga cagcagagag                                                   20


<210>  11864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11864
cagcugaguc uucggaugag                                                   20


<210>  11865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11865
ucggaugagg ugagggguag                                                   20


<210>  11866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11866
gcacuaaggg cuaaaauaaa                                                   20


<210>  11867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11867
ucuucauuca ccugcaaauu                                                   20


<210>  11868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11868
ggcguaaggc cucacguauc                                                   20


<210>  11869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11869
ugccacugca gugagggcuu                                                   20


<210>  11870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11870
aaagccacug cgguuguggu                                                   20


<210>  11871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11871
caccaucuca cuccacuacc                                                   20


<210>  11872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11872
cccuggcucu ugcugcauga                                                   20


<210>  11873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11873
ccccaucaug cagcaagagc                                                   20


<210>  11874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11874
cgguugacac cgacugccuc                                                   20


<210>  11875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11875
accgggaccu uccugggcag                                                   20


<210>  11876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11876
gugucaaccg ggaccuuccu                                                   20


<210>  11877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11877
cagaguaggu aagguaacau                                                   20


<210>  11878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11878
aaggucacag aguagguaag                                                   20


<210>  11879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11879
gguugccucc guagcccuca                                                   20


<210>  11880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11880
uuugcacaug agaaagcuga                                                   20


<210>  11881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11881
caucaaacac ccccaucacu                                                   20


<210>  11882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11882
augcccugca gccaaagacc                                                   20


<210>  11883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11883
uuggcugcag ggcauugaca                                                   20


<210>  11884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11884
cugaaagagg uauuagaaag                                                   20


<210>  11885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11885
cucuccuguc agguuggagg                                                   20


<210>  11886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11886
gguuggaggg acucuggaag                                                   20


<210>  11887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11887
cuccaaccug acaggagagu                                                   20


<210>  11888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11888
gcagagccca gguucccugc                                                   20


<210>  11889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11889
uggcgagcgg ucggcagagc                                                   20


<210>  11890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11890
accccacauu gcaaauguuu                                                   20


<210>  11891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11891
acagaucggu cccccagggc                                                   20


<210>  11892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11892
uucugauucu ggagccuggg                                                   20


<210>  11893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11893
acauuuaugc aguggggagg                                                   20


<210>  11894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11894
cccuccacac uagcacaggg                                                   20


<210>  11895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11895
uggaagaugu ugcagggggg                                                   20


<210>  11896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11896
cuucccccag uaccuagcac                                                   20


<210>  11897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11897
gaugcauguc ucuuccccca                                                   20


<210>  11898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11898
ugggggaacc ucuacuaccc                                                   20


<210>  11899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11899
gaaagagcuc uguuccucca                                                   20


<210>  11900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11900
auauauuuug auguggacag                                                   20


<210>  11901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11901
acaucaaaau auauagacuc                                                   20


<210>  11902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11902
guuacagcau gcaugcuguu                                                   20


<210>  11903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11903
ucacucacaa acaaaaucaa                                                   20


<210>  11904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11904
augaauugug auugguccaa                                                   20


<210>  11905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11905
aaagccaauc augacaaucc                                                   20


<210>  11906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11906
ugauuggcuu uggaccaauc                                                   20


<210>  11907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11907
ugagaucgag uucuggccag                                                   20


<210>  11908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11908
uacuggccag aacucgaucu                                                   20


<210>  11909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11909
cuuucugaag uuuuugcuuu                                                   20


<210>  11910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11910
cuucugcauu uuuauuauaa                                                   20


<210>  11911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11911
ugcagucaug agggaaauuc                                                   20


<210>  11912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11912
ugagggaaau uccaagagau                                                   20


<210>  11913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11913
agcaucucug ugaaucucuu                                                   20


<210>  11914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11914
cguggcaccu guauuggcua                                                   20


<210>  11915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11915
ucugcaugaa aaugaccuug                                                   20


<210>  11916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11916
uuuucaugca gaugaccugg                                                   20


<210>  11917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11917
ccacgagguc cccaggccug                                                   20


<210>  11918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11918
gaucuccaaa acccagccca                                                   20


<210>  11919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11919
gccaucucag ccagggagga                                                   20


<210>  11920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11920
ggguguuaau ggugcagaga                                                   20


<210>  11921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11921
ccaccuccac uugcccuggg                                                   20


<210>  11922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11922
agggugaaag gaaagaaucc                                                   20


<210>  11923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11923
uuuggaucca aauggccagu                                                   20


<210>  11924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11924
gggugaccca guuggguauu                                                   20


<210>  11925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11925
ccccgacugg ccauuuggau                                                   20


<210>  11926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11926
gauggcagcc ccacuccucc                                                   20


<210>  11927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11927
uuccuccccc uccaugcuug                                                   20


<210>  11928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11928
ggacuuucua aagcaguuuu                                                   20


<210>  11929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11929
ugacaugagg caagcaugga                                                   20


<210>  11930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11930
aacaagauag cacaucuaaa                                                   20


<210>  11931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11931
caccgugaau uuguagcaga                                                   20


<210>  11932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11932
ugucccaucu gcugccaagg                                                   20


<210>  11933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11933
caucugcugc caaggccuag                                                   20


<210>  11934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11934
ccaccccucc agccugugcu                                                   20


<210>  11935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11935
ccaggcugga ccccaccaca                                                   20


<210>  11936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11936
agccuggaga caguacccug                                                   20


<210>  11937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11937
ggagagagug guuuuagagc                                                   20


<210>  11938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11938
aauucgcuuu ggucuggaga                                                   20


<210>  11939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11939
cagcuguagg agcuccuggu                                                   20


<210>  11940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11940
agcagaagag auugucacau                                                   20


<210>  11941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11941
cauagaggac ucccuuggca                                                   20


<210>  11942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11942
ucuaugugac aaucucuucu                                                   20


<210>  11943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11943
ccuccuccag gcagcacucc                                                   20


<210>  11944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11944
ugagaauuau caggcaaaga                                                   20


<210>  11945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11945
cccagcucca cucugcagcc                                                   20


<210>  11946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11946
aggucaccca gcuccacucu                                                   20


<210>  11947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11947
ugcuaguguu ucuccaagca                                                   20


<210>  11948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11948
aaggccaccu caguccugcu                                                   20


<210>  11949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11949
gggguggagg cagaggugga                                                   20


<210>  11950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11950
agcuucugca gcucuuccua                                                   20


<210>  11951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11951
aagagggucc agcuucugca                                                   20


<210>  11952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11952
ccacugacac auuuuauccu                                                   20


<210>  11953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11953
guggggacag gggaugggca                                                   20


<210>  11954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11954
aucuuguuca cugcuguacc                                                   20


<210>  11955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11955
guaacaugga aggugaucaa                                                   20


<210>  11956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11956
cccucuuguc acccaggaug                                                   20


<210>  11957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11957
cccaggauga agugcaaugg                                                   20


<210>  11958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11958
cuacuaaaaa cacaaaauua                                                   20


<210>  11959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11959
ggcuggucuu gaacuccuga                                                   20


<210>  11960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11960
ugaacuccug acuucaggug                                                   20


<210>  11961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11961
ggaguucaag accagccuga                                                   20


<210>  11962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11962
cucuuuugua cacaucaagg                                                   20


<210>  11963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11963
gccuggcucu cucugucucu                                                   20


<210>  11964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11964
gagaacagca acagcucuuc                                                   20


<210>  11965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11965
ccacucccug ccggcuuaaa                                                   20


<210>  11966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11966
uccuggcacc ugccacaggc                                                   20


<210>  11967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11967
gccacuucau ggagaaaagg                                                   20


<210>  11968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11968
ccacccucuc cucuccuccc                                                   20


<210>  11969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11969
ugacccucuu uuguucagaa                                                   20


<210>  11970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11970
ugaccagcac gccggccuca                                                   20


<210>  11971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11971
ccuaaccuca ggagagggcc                                                   20


<210>  11972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11972
ccagcugggc caugcacugc                                                   20


<210>  11973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11973
aguuauaaug gugguaggaa                                                   20


<210>  11974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11974
gaugggcacu gaauccgggc                                                   20


<210>  11975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11975
cuucugugag acuuggcucc                                                   20


<210>  11976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11976
cacagaaggg acaggcuagg                                                   20


<210>  11977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11977
ccugugcucu caucugccuc                                                   20


<210>  11978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11978
acagggaggc agaugagagc                                                   20


<210>  11979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11979
ucugagccca cggccugccc                                                   20


<210>  11980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11980
agcugggcaa ggcugcugcu                                                   20


<210>  11981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11981
cucucucccu auuccuuccu                                                   20


<210>  11982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11982
uccaaauccu gcuccagcac                                                   20


<210>  11983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11983
cuuucuggcc uugacuggaa                                                   20


<210>  11984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11984
aggccagaaa gggaccgaaa                                                   20


<210>  11985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11985
cccaaggaca cugcugccgu                                                   20


<210>  11986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11986
uugggggaca ggggccuucc                                                   20


<210>  11987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11987
cugcaguccu uuccccccgc                                                   20


<210>  11988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11988
uuuccccccg ccugagaggg                                                   20


<210>  11989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11989
ccuugcucuc agugccccac                                                   20


<210>  11990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11990
uucucuccuc cauaaacgca                                                   20


<210>  11991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11991
ugcgccacac agcaauguuu                                                   20


<210>  11992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11992
uugccugaaa cauugcugug                                                   20


<210>  11993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11993
gucguugccu gaaacauugc                                                   20


<210>  11994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11994
uguauguggu cugucguugc                                                   20


<210>  11995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11995
ccucgcuuag agacgucaua                                                   20


<210>  11996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11996
cuaagcgagg ugacaggagu                                                   20


<210>  11997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11997
uagcugucag gccucugagc                                                   20


<210>  11998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11998
ggccucugag cccaagccaa                                                   20


<210>  11999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  11999
caggggaugc gauggcuugg                                                   20


<210>  12000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12000
ucaguuaagg uggggcaggg                                                   20


<210>  12001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12001
uugccuuaac ugaugacauu                                                   20


<210>  12002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12002
ucaguuaagg caaggaccag                                                   20


<210>  12003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12003
uuuuccuggu ucauccuggc                                                   20


<210>  12004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12004
caaggugcuc aguggaggug                                                   20


<210>  12005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12005
aaggggguuu guucucuggc                                                   20


<210>  12006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12006
gcgaagggag auaaggguag                                                   20


<210>  12007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12007
aaaaagagag ucagcgaagg                                                   20


<210>  12008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12008
cuucacacgg augcacaugu                                                   20


<210>  12009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12009
cccgauccga guaacggcac                                                   20


<210>  12010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12010
uccugcucuu ugcuccauga                                                   20


<210>  12011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12011
uagguggauc uuucucaugg                                                   20


<210>  12012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12012
ucagaccgac cagcccaaga                                                   20


<210>  12013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12013
gaggaccuga ggucguaggu                                                   20


<210>  12014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12014
gucugaggac cugaggucgu                                                   20


<210>  12015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12015
gguaagcugc cucuuuuuac                                                   20


<210>  12016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12016
cuaccaaaaa augaaagaaa                                                   20


<210>  12017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12017
cuuuugucuc uaccaaaaaa                                                   20


<210>  12018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12018
cggacuggga aggcagccuu                                                   20


<210>  12019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12019
gugaccggca ccgggguuuu                                                   20


<210>  12020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12020
gaccacgcag ggacgccugc                                                   20


<210>  12021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12021
gacacccuug aaacgugagu                                                   20


<210>  12022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12022
cugcgugguc ugacacccuu                                                   20


<210>  12023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12023
uucacccuua gcggcaaguc                                                   20


<210>  12024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12024
cgcuuuccua gggggcaagg                                                   20


<210>  12025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12025
uugcccccua ggaaagcggg                                                   20


<210>  12026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12026
gggugcggaa auaagggauu                                                   20


<210>  12027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12027
caacccccuc ucugcuuuuc                                                   20


<210>  12028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12028
cuacgcucuc uuuucucagg                                                   20


<210>  12029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12029
uuaagaacuu aaaaccucuu                                                   20


<210>  12030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12030
ggugugaguu gaagagguuu                                                   20


<210>  12031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12031
aguuuguauu ggggccaagu                                                   20


<210>  12032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12032
uguaggaugc agaaaucaaa                                                   20


<210>  12033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12033
aaaaaugggc aaauggucug                                                   20


<210>  12034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12034
gaggugccuu acguccaggc                                                   20


<210>  12035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12035
aggcauuuuu cacacuucgu                                                   20


<210>  12036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12036
ccucaguccc aaccccaagc                                                   20


<210>  12037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12037
caaccccaag cgucgcugag                                                   20


<210>  12038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12038
cugagucuuu ccagucuucc                                                   20


<210>  12039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12039
uuccagucuu ccuuuucuac                                                   20


<210>  12040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12040
uccuuuucua cagacccauc                                                   20


<210>  12041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12041
guagaaaagg aagacuggaa                                                   20


<210>  12042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12042
gaugggucug uagaaaagga                                                   20


<210>  12043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12043
caauucuucc ucagccuccg                                                   20


<210>  12044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12044
cggaacgaaa cugugagccg                                                   20


<210>  12045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12045
agguuaaugc uccuuuuucu                                                   20


<210>  12046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12046
ugaacugggc uggauuuuua                                                   20


<210>  12047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12047
caggguugcu gccaaacgag                                                   20


<210>  12048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12048
agggcuguaa agugucucag                                                   20


<210>  12049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12049
aagggccguc uuauucucaa                                                   20


<210>  12050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12050
uauucucaau acucauuuua                                                   20


<210>  12051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12051
ggaguggauu ggguaauaaa                                                   20


<210>  12052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12052
cacaguggag gcaaggaauu                                                   20


<210>  12053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12053
caucugugug ggaccccacu                                                   20


<210>  12054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12054
cacacagaug ggacgcggcu                                                   20


<210>  12055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12055
gauuuucagu ggggucccac                                                   20


<210>  12056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12056
gagagccuug ggccagaguu                                                   20


<210>  12057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12057
gucagagagc cuugggccag                                                   20


<210>  12058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12058
ucagccgcua agccgagaag                                                   20


<210>  12059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12059
gucuucagcc gcuaagccga                                                   20


<210>  12060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12060
gggggcuucc gaggcgaucg                                                   20


<210>  12061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12061
gugauggucu gggggcuucc                                                   20


<210>  12062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12062
ccuucuuaau caauacggag                                                   20


<210>  12063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12063
auacccacaa caguuaugga                                                   20


<210>  12064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12064
aaguuggcac cagaguuggg                                                   20


<210>  12065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12065
cagccuaaua agggaacugg                                                   20


<210>  12066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12066
gggaagcaga uaauuuaaag                                                   20


<210>  12067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12067
aggaauaguc agggaagcag                                                   20


<210>  12068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12068
uccucuugua ccccccaccu                                                   20


<210>  12069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12069
uuaaucuuuu uaaagcgugc                                                   20


<210>  12070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12070
uaaaaccaga caagccuuac                                                   20


<210>  12071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12071
gguuuuagga cagguaaaau                                                   20


<210>  12072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12072
ucccagccuc ucuucacuuu                                                   20


<210>  12073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12073
aagugaaagu gaagagaggc                                                   20


<210>  12074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12074
gucaaaguga aagugaagag                                                   20


<210>  12075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12075
gggucaguca aagugaaagu                                                   20


<210>  12076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12076
gugaagcuuu gcagcaguac                                                   20


<210>  12077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12077
gacugaucuc ucaaacccca                                                   20


<210>  12078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12078
gacacgauug gcagggagag                                                   20


<210>  12079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12079
gaauucuuac acaagagcca                                                   20


<210>  12080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12080
uggcucuugu guaagaauuc                                                   20


<210>  12081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12081
aaacaacuug accuuacugu                                                   20


<210>  12082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12082
aguuguuugg acagaaagcc                                                   20


<210>  12083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12083
gcgugcagcg gcugccacug                                                   20


<210>  12084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12084
gguaugagga agaaaauaga                                                   20


<210>  12085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12085
gggccaggaa caacgguaau                                                   20


<210>  12086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12086
ggugugguau caggaauaau                                                   20


<210>  12087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12087
ugggggucag gugugguauc                                                   20


<210>  12088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12088
gguggaucag agagauacag                                                   20


<210>  12089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12089
gccuuugcug guguguggcg                                                   20


<210>  12090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12090
ugaauaaucc cugaggagua                                                   20


<210>  12091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12091
uggguggggc aaauccucga                                                   20


<210>  12092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12092
gauaacuaaa auaccucuua                                                   20


<210>  12093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12093
ggagguauuu uaguuacugg                                                   20


<210>  12094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12094
gagaaggcca ccgcagucau                                                   20


<210>  12095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12095
ucucuucccu ucugucagac                                                   20


<210>  12096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12096
gacacaauuc cucaguuuag                                                   20


<210>  12097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12097
gacagaaggg aagagaugac                                                   20


<210>  12098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12098
gauaacagau gagccuuuau                                                   20


<210>  12099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12099
aaucagccaa gcauuuuuuc                                                   20


<210>  12100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12100
uccgucuuca agaaaaguag                                                   20


<210>  12101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12101
ucaagaaaag uagaacagac                                                   20


<210>  12102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12102
guucuacuuu ucuugaagac                                                   20


<210>  12103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12103
uuuaaaaaca caccucacca                                                   20


<210>  12104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12104
uuuuuggugg cugagcuugg                                                   20


<210>  12105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12105
aguccuuuuu gguggcugag                                                   20


<210>  12106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12106
ucggaaugcu acaagguaca                                                   20


<210>  12107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12107
auacaggagc uuaaaugggc                                                   20


<210>  12108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12108
cauuccagac accagaccaa                                                   20


<210>  12109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12109
ggaaugagac uggggccuaa                                                   20


<210>  12110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12110
ggugucugga augagacugg                                                   20


<210>  12111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12111
aaguuggucu ggugucugga                                                   20


<210>  12112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12112
ucccuacuau cuucugucua                                                   20


<210>  12113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12113
agucauacuc cuauucaccg                                                   20


<210>  12114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12114
uacuccuauu caccguucuc                                                   20


<210>  12115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12115
ugccagcaaa gauuauuuau                                                   20


<210>  12116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12116
uagguccucc caauucuuag                                                   20


<210>  12117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12117
ucccaauucu uaguccuuuu                                                   20


<210>  12118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12118
uuuuauaccu guuuuucucc                                                   20


<210>  12119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12119
uauagaauga uuggugaugg                                                   20


<210>  12120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12120
ggccucugag cccaagccac                                                   20


<210>  12121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12121
caggggaugc gauggcgugg                                                   20


<210>  12122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12122
ucaguuaagg uggggcaggg                                                   20


<210>  12123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12123
uugccuuaac ugaugacauu                                                   20


<210>  12124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12124
ucaguuaagg caaggaccgg                                                   20


<210>  12125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12125
uuucccuggu ucauccuggc                                                   20


<210>  12126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12126
caaggugcuc agugggggug                                                   20


<210>  12127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12127
caaggugcuc agugggcagg                                                   20


<210>  12128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12128
aaggggguuu guuaucuggc                                                   20


<210>  12129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12129
gcgaagggag auaagggugg                                                   20


<210>  12130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12130
gaaaagagag ucagcgaagg                                                   20


<210>  12131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12131
cuucacacgg acgcgcauga                                                   20


<210>  12132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12132
gugugaagag accaccaaac                                                   20


<210>  12133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12133
uagcacaguu acuuaaaaaa                                                   20


<210>  12134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12134
cuggccuuca cauucacucc                                                   20


<210>  12135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12135
gugagugagu ggggagugaa                                                   20


<210>  12136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12136
ugcaagcucu guucaugcua                                                   20


<210>  12137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12137
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  12138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12138
cacucuguug cccagggugg                                                   20


<210>  12139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12139
cagcuacucg ggaggcugag                                                   20


<210>  12140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12140
cgaucuccug accucgugau                                                   20


<210>  12141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12141
ggagaucgag accauccugg                                                   20


<210>  12142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12142
guagucuagg agcaauaggc                                                   20


<210>  12143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12143
aggagcaaua ggcugucuau                                                   20


<210>  12144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12144
aucccauaua gucucggugu                                                   20


<210>  12145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12145
cgguguguag ugggcuaccc                                                   20


<210>  12146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12146
aacuauauga uauucgcacc                                                   20


<210>  12147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12147
uggugcgaau aucauauagu                                                   20


<210>  12148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12148
cuggcaauuu ugucauggug                                                   20


<210>  12149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12149
ugcauccaua ugucccuggc                                                   20


<210>  12150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12150
ucagauuaca ccggaagacu                                                   20


<210>  12151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12151
uccgguguaa ucugaugaca                                                   20


<210>  12152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12152
guugcacgcu cuggcaccuc                                                   20


<210>  12153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12153
uuccaccucc agagaccuug                                                   20


<210>  12154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12154
cuggaggugg aaggacugag                                                   20


<210>  12155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12155
cuacgauaac aagcuccucc                                                   20


<210>  12156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12156
gaaagggcgu guuuggaaug                                                   20


<210>  12157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12157
augaaaauau uggaguuggg                                                   20


<210>  12158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12158
gccucucacu caccuccuug                                                   20


<210>  12159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12159
gggcugggag gaggggagau                                                   20


<210>  12160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12160
agucugccau ccacccuccc                                                   20


<210>  12161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12161
gccauccacc cuccccacau                                                   20


<210>  12162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12162
cacucacaaa ccacucggcu                                                   20


<210>  12163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12163
uaaaaaccca cuccguuucc                                                   20


<210>  12164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12164
auuucucugc cugacuuauu                                                   20


<210>  12165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12165
ggcagagaaa uggacuugga                                                   20


<210>  12166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12166
gugaaauggc aauaguuaca                                                   20


<210>  12167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12167
aucucuucgu cugugaaaug                                                   20


<210>  12168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12168
cuuccugugu gucuaucucu                                                   20


<210>  12169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12169
cgcagucucu uccugugugu                                                   20


<210>  12170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12170
uggagcccag gccuguggcc                                                   20


<210>  12171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12171
gggggcaggg cagcacugca                                                   20


<210>  12172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12172
uugucugggg gcagggcagc                                                   20


<210>  12173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12173
auuuucucau uggaauagga                                                   20


<210>  12174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12174
agaggauaga gccuuccacc                                                   20


<210>  12175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12175
caacuguaac acuuccauca                                                   20


<210>  12176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12176
gugguggccg ucuuuggcuc                                                   20


<210>  12177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12177
uuggcuccuc uuccugcauu                                                   20


<210>  12178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12178
cuacacaggc cuuccuggug                                                   20


<210>  12179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12179
gguguucuga uuuagccaug                                                   20


<210>  12180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12180
gaugcugggg uccgguguuc                                                   20


<210>  12181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12181
cgugggccuc auuugaccca                                                   20


<210>  12182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12182
aaugaggccc acgggacaag                                                   20


<210>  12183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12183
cuuccuccuc cuggacaugc                                                   20


<210>  12184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12184
aggaggagga agugaccaac                                                   20


<210>  12185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12185
ccugucauug aauuacguug                                                   20


<210>  12186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12186
uugaauuacg uugauauguu                                                   20


<210>  12187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12187
acauaucaac guaauucaau                                                   20


<210>  12188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12188
cauggaacuu aggggagaug                                                   20


<210>  12189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12189
cuuaaggagc agcuggggag                                                   20


<210>  12190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12190
ccucucacau cucaucugug                                                   20


<210>  12191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12191
acagaugaga ugugagaggu                                                   20


<210>  12192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12192
cacugcugcc ucugaucuaa                                                   20


<210>  12193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12193
cccaccugcu cucucugcuu                                                   20


<210>  12194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12194
ccgacaucua uuuuccaaau                                                   20


<210>  12195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12195
gugaccaggg uaaaagcaga                                                   20


<210>  12196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12196
cucugauaug guuucgcugu                                                   20


<210>  12197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12197
ccauucaaau cucagcuuga                                                   20


<210>  12198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12198
cucccacaac acgugggaau                                                   20


<210>  12199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12199
uucccaugcu auucucaugg                                                   20


<210>  12200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12200
caggagaucu gauggguuua                                                   20


<210>  12201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12201
ugauucugag accuccgcag                                                   20


<210>  12202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12202
cagaaucaug acgggaaacg                                                   20


<210>  12203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12203
aauuaaaccu auuuuucuuc                                                   20


<210>  12204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12204
cagguauguc uuuaucagca                                                   20


<210>  12205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12205
uuaucagcag cauaaaaaug                                                   20


<210>  12206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12206
auuuuuaugc ugcugauaaa                                                   20


<210>  12207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12207
uuuccacauu uucagguauc                                                   20


<210>  12208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12208
ucuucugagc ccuccaaacu                                                   20


<210>  12209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12209
cuaggaaguu ccaaacuuuc                                                   20


<210>  12210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12210
aagccauuga acaagucucu                                                   20


<210>  12211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12211
cagagggggc agaugaggaa                                                   20


<210>  12212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12212
ccuuugcucc aguucccaac                                                   20


<210>  12213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12213
cuuugcuaaa acauaacagg                                                   20


<210>  12214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12214
aacuugagag agacgauuua                                                   20


<210>  12215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12215
cucucaaguu cgacguuccg                                                   20


<210>  12216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12216
ccucuugaau gcuuugcugc                                                   20


<210>  12217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12217
ccaggccaug ucagggaccu                                                   20


<210>  12218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12218
gggaccuuca caacagcucc                                                   20


<210>  12219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12219
cugacauggc cuggagacau                                                   20


<210>  12220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12220
cugggcugca cacagcacag                                                   20


<210>  12221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12221
cagcugcucc aggcauggcu                                                   20


<210>  12222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12222
acauacagcu ugggcugugg                                                   20


<210>  12223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12223
uggggcuucc accucugaag                                                   20


<210>  12224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12224
agaauugagg uuugggaacc                                                   20


<210>  12225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12225
ucugaaaucu agguggaggu                                                   20


<210>  12226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12226
aggcagaaau uugcuucagg                                                   20


<210>  12227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12227
uaccagaggu ucuccaugag                                                   20


<210>  12228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12228
cagcccccag acagaauccc                                                   20


<210>  12229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12229
gggggcugug accccacauu                                                   20


<210>  12230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12230
uccagacccc agaaugguag                                                   20


<210>  12231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12231
ggaggacagu ggcccucuac                                                   20


<210>  12232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12232
guggaucuac cauucugggg                                                   20


<210>  12233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12233
gcagauuuuc caggagaaca                                                   20


<210>  12234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12234
caggggcaga gcugcccaag                                                   20


<210>  12235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12235
ugggcagcuc ugccccugug                                                   20


<210>  12236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12236
cgcugaugca agagguaggu                                                   20


<210>  12237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12237
aaggagauca uuuuggagcu                                                   20


<210>  12238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12238
aauuuuaaag cuccaaaaug                                                   20


<210>  12239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12239
aaaauccagu ggugcaguca                                                   20


<210>  12240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12240
cuuccaccua ugagccugua                                                   20


<210>  12241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12241
cagaugagac uuuggacugu                                                   20


<210>  12242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12242
caucugagac aaggcaaguc                                                   20


<210>  12243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12243
aaagucucau cugagacaag                                                   20


<210>  12244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12244
acaguccaaa gucucaucug                                                   20


<210>  12245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12245
augcugaaau gaguuaaaac                                                   20


<210>  12246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12246
cucaaaguuu uaacucauuu                                                   20


<210>  12247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12247
ucacauuuca aaaccaauca                                                   20


<210>  12248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12248
ggggcagaau gaugugguuu                                                   20


<210>  12249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12249
cccagaauuc ccacauguug                                                   20


<210>  12250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12250
uucccaugcu auucucguga                                                   20


<210>  12251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12251
cauaggaucu gaugggauua                                                   20


<210>  12252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12252
aauuaaaccu cuuuuucuuc                                                   20


<210>  12253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12253
uggguauguc uuuaucagca                                                   20


<210>  12254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12254
uuaucagcag caugaaaacg                                                   20


<210>  12255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12255
ccagaauggu uggcgagcuc                                                   20


<210>  12256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12256
gcccccacac cagccuccag                                                   20


<210>  12257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12257
ggggcagcac uucuccacug                                                   20


<210>  12258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12258
acggcccguc cucucagcuc                                                   20


<210>  12259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12259
ucucagcucc uuuccuccag                                                   20


<210>  12260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12260
cccacccucu ucucuuuucc                                                   20


<210>  12261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12261
ucuguuccgc ccuacuagag                                                   20


<210>  12262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12262
guuccgcccu acuagaggga                                                   20


<210>  12263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12263
cugguacaua auagguguuc                                                   20


<210>  12264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12264
uuaaacauac augucaggcu                                                   20


<210>  12265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12265
ggcucuagcu uggugcuagg                                                   20


<210>  12266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12266
uccuuggcau cccuagcacc                                                   20


<210>  12267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12267
ggucauccuu ggcaucccua                                                   20


<210>  12268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12268
ugaacucagu auaagcaggg                                                   20


<210>  12269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12269
uccccacggg ucgugaacuc                                                   20


<210>  12270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12270
gagagugcau cugucuuccc                                                   20


<210>  12271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12271
ccuuccaugu agccccuacu                                                   20


<210>  12272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12272
ccccgaccuc aggagggaga                                                   20


<210>  12273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12273
gggagacagg gcugcaacuc                                                   20


<210>  12274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12274
acucugaccc auagcugugu                                                   20


<210>  12275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12275
gaguggacuu aaacucccuu                                                   20


<210>  12276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12276
auuaaacaga gaugauaguc                                                   20


<210>  12277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12277
cagcacagca ugucccacag                                                   20


<210>  12278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12278
cacagggcug gggcgaauga                                                   20


<210>  12279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12279
cauucgcccc agcccugugg                                                   20


<210>  12280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12280
acaaagcauu uucauccuuc                                                   20


<210>  12281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12281
uuugggguuu uucugaggug                                                   20


<210>  12282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12282
cacucuguug cccagcugaa                                                   20


<210>  12283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12283
cgaacuccug accucaauug                                                   20


<210>  12284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12284
ggaguucgag accagccugg                                                   20


<210>  12285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12285
gccucggacu cccaaaaugc                                                   20


<210>  12286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12286
gaggcagacg gaucaauuga                                                   20


<210>  12287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12287
gcauucuaca guuauaucau                                                   20


<210>  12288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12288
ugaugucugc auucuacagu                                                   20


<210>  12289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12289
guaccuuaaa ucuuauguug                                                   20


<210>  12290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12290
cugcauaaac aacauaagau                                                   20


<210>  12291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12291
aacaucaaua acuuuuaaac                                                   20


<210>  12292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12292
auauauaaac cuccauuuau                                                   20


<210>  12293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12293
guucauaugg ugggauauuu                                                   20


<210>  12294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12294
cuccauugau gaauguuugg                                                   20


<210>  12295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12295
uauauuacac uucuguuugc                                                   20


<210>  12296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12296
ccucuaauaa aacucucacu                                                   20


<210>  12297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12297
gagccaggac ucauaccacc                                                   20


<210>  12298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12298
uggcuccgac ugcaacaugu                                                   20


<210>  12299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12299
cgcugcuggg agccacaggg                                                   20


<210>  12300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12300
gggcuuccua uacccuguuc                                                   20


<210>  12301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12301
uuacugaguc agaagcuguu                                                   20


<210>  12302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12302
gaagcuguuu uaagagcuga                                                   20


<210>  12303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12303
uggacccuuu guccauccug                                                   20


<210>  12304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12304
aggacagcag cacgcuuuuc                                                   20


<210>  12305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12305
auccugggcc auugggccag                                                   20


<210>  12306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12306
uugcuagauu auauuagggc                                                   20


<210>  12307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12307
acuugccuaa uuauuuccuu                                                   20


<210>  12308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12308
guauauagca cauuuucaca                                                   20


<210>  12309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12309
guagcaaacu gugaaaaugu                                                   20


<210>  12310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12310
caagggaguu uuguuacuaa                                                   20


<210>  12311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12311
uaguaacaaa acucccuugc                                                   20


<210>  12312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12312
uuucuaauca gggagaaaaa                                                   20


<210>  12313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12313
uccuuuuuua aaucuuuuuu                                                   20


<210>  12314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12314
ugaaauaaaa ggcugauaag                                                   20


<210>  12315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12315
aacuuaucag ccuuuuauuu                                                   20


<210>  12316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12316
aaaaucaauc aacaaacugg                                                   20


<210>  12317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12317
cuuauguaug uugcaaaucu                                                   20


<210>  12318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12318
cuucauuuuu ucauuuuggc                                                   20


<210>  12319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12319
uugaacuguc ucuucauuuu                                                   20


<210>  12320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12320
aaauauuugg caacucugug                                                   20


<210>  12321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12321
cacccaggcc aacacagagu                                                   20


<210>  12322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12322
aauguaggaa acugcaauca                                                   20


<210>  12323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12323
ugugucucgc uuaggagaag                                                   20


<210>  12324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12324
cgcuuaggag aaggaaaugu                                                   20


<210>  12325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12325
cuuuugugug gaagcugcau                                                   20


<210>  12326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12326
ccucuuugcu uuccgucagc                                                   20


<210>  12327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12327
gccucagugu ucagcaaugu                                                   20


<210>  12328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12328
gguucugggg ugaggguaau                                                   20


<210>  12329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12329
uugauggaca ugugagguga                                                   20


<210>  12330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12330
aucaaggacu uugcuucacu                                                   20


<210>  12331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12331
caccucacau guccaucaag                                                   20


<210>  12332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12332
aagguuuauu ucugucucac                                                   20


<210>  12333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12333
ucccacgagc agugcuggag                                                   20


<210>  12334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12334
uuauccauag cuguuugcac                                                   20


<210>  12335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12335
guccuuaucc auagcuguuu                                                   20


<210>  12336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12336
uuugcuauug caauccaagu                                                   20


<210>  12337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12337
uuagccaauu uccuauuggu                                                   20


<210>  12338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12338
uaaccuagcc cuaaucucgg                                                   20


<210>  12339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12339
gauuaaguug ucccucucca                                                   20


<210>  12340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12340
cucuccaccc caccaauaua                                                   20


<210>  12341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12341
acuuuuauaa aacuacuugg                                                   20


<210>  12342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12342
gcacagcucu aaucggcgcc                                                   20


<210>  12343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12343
caaguaucuc uccccuuucu                                                   20


<210>  12344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12344
uuggauuuag ggaccauccu                                                   20


<210>  12345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12345
cuaaauccaa ugacugauau                                                   20


<210>  12346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12346
auuacaucug caaagaucuc                                                   20


<210>  12347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12347
cauucaaaag uaccaggggu                                                   20


<210>  12348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12348
uagacuuauc uuuuuggggg                                                   20


<210>  12349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12349
aagacuaacc ccugguacuu                                                   20


<210>  12350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12350
cccaaaaaga uaagucuaag                                                   20


<210>  12351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12351
gcagccacca uugcugugag                                                   20


<210>  12352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12352
augaggggaa ggcaauggcu                                                   20


<210>  12353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12353
cucaaaaugc uuuucuagcc                                                   20


<210>  12354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12354
gcugaguaua agaggauggu                                                   20


<210>  12355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12355
ccucugcccu gaaggaggaa                                                   20


<210>  12356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12356
acacccaucc uuuuccccuc                                                   20


<210>  12357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12357
gaagccucuu cuggggccuc                                                   20


<210>  12358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12358
ccuucucccu cuucucaaau                                                   20


<210>  12359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12359
cuucucaucc cauauccucc                                                   20


<210>  12360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12360
cagagcccag ggugcuuccu                                                   20


<210>  12361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12361
agcaugcagu ggguguguuc                                                   20


<210>  12362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12362
ccaggcccag gaagggggcu                                                   20


<210>  12363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12363
cucugugcac aggcuucauc                                                   20


<210>  12364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12364
uuaccgugca cccagagaau                                                   20


<210>  12365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12365
caaaggggag cagcagggaa                                                   20


<210>  12366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12366
gcaaaccaug agcuccuacu                                                   20


<210>  12367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12367
gaguuauccc caucgagccc                                                   20


<210>  12368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12368
cugucaaccc acugguugca                                                   20


<210>  12369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12369
acccacuggu ugcacugucu                                                   20


<210>  12370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12370
uugugcacug gcucucugga                                                   20


<210>  12371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12371
uugcaaacaa aguggaaaga                                                   20


<210>  12372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12372
aaaguugaug cucuuuccac                                                   20


<210>  12373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12373
auacugggaa gaaacaaagg                                                   20


<210>  12374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12374
ugccacaugu acaaucugag                                                   20


<210>  12375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12375
aguugauuuc uugaacaugg                                                   20


<210>  12376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12376
uauagguaca uucagaauuc                                                   20


<210>  12377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12377
uugcaaacuu aaaaccugaa                                                   20


<210>  12378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12378
agccuacaug cauuucaagg                                                   20


<210>  12379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12379
gugugcaggg ugcauaaagg                                                   20


<210>  12380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12380
aggcuaaguu uagaaggcug                                                   20


<210>  12381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12381
acaguaggau ugauucagaa                                                   20


<210>  12382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12382
cacuggucag caggagacaa                                                   20


<210>  12383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12383
gcaggagaca agguggaccc                                                   20


<210>  12384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12384
ccugcugacc agugagacuu                                                   20


<210>  12385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12385
accuugucuc cugcugacca                                                   20


<210>  12386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12386
ggcaucccac gcagggugag                                                   20


<210>  12387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12387
gauuacgcgc agagggaaga                                                   20


<210>  12388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12388
ggggguuccg uuaauguuua                                                   20


<210>  12389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12389
gauggggcuc ugguggcgug                                                   20


<210>  12390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12390
agcacccaca cccuagaagg                                                   20


<210>  12391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12391
cugcggaaac cuucuagggu                                                   20


<210>  12392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12392
aggcgcucau gguugcaggc                                                   20


<210>  12393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12393
gagccuggag gagugagcca                                                   20


<210>  12394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12394
cacugccugg cucacuccuc                                                   20


<210>  12395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12395
cggcccgccc gagccagucu                                                   20


<210>  12396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12396
uugcagcagc ggcucccagc                                                   20


<210>  12397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12397
uccccaccgc aaggcucaag                                                   20


<210>  12398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12398
acgccggcgg cgccuugagc                                                   20


<210>  12399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12399
ccucgccagg acagcaaccu                                                   20


<210>  12400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12400
uggcgaggag accuagaggc                                                   20


<210>  12401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12401
gcuccaggcg guccuggugg                                                   20


<210>  12402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12402
ugguggccgc ugccacugcu                                                   20


<210>  12403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12403
cgcgggcgcc cgugcgcagg                                                   20


<210>  12404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12404
uccugcgcac gggcgcccgc                                                   20


<210>  12405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12405
ucguccuccu gcgcacgggc                                                   20


<210>  12406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12406
ccguccucgu ccuccugcgc                                                   20


<210>  12407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12407
uccucggaac gcaaggcuag                                                   20


<210>  12408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12408
cggcugcggg uucgccccgg                                                   20


<210>  12409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12409
ccgagggcuc uucgcuuggc                                                   20


<210>  12410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12410
ccaagaucgu gccaagcgaa                                                   20


<210>  12411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12411
ucccccgccg ccuugccugc                                                   20


<210>  12412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12412
ccgcucucca ccgugcuccc                                                   20


<210>  12413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12413
ccaaagagcc ggccgucccc                                                   20


<210>  12414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12414
cccaaccccg cgaaccuucc                                                   20


<210>  12415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12415
cggguagggc cuucucucca                                                   20


<210>  12416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12416
uucccacccc gccccugucu                                                   20


<210>  12417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12417
uaaagaaauu gccucgugcu                                                   20


<210>  12418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12418
uuuaggacuc aggcagggaa                                                   20


<210>  12419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12419
uaaaggacgc caaugggccu                                                   20


<210>  12420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12420
caguaccagg cgcaccaccu                                                   20


<210>  12421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12421
gccgaccgug ugcggggcga                                                   20


<210>  12422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12422
gcagacagcc aggugggcug                                                   20


<210>  12423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12423
cgccccggga agaagcuucc                                                   20


<210>  12424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12424
ugggcuggua auacuuagaa                                                   20


<210>  12425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12425
cccagcuugg agucagaugu                                                   20


<210>  12426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12426
gauguggggu ugaaucuugg                                                   20


<210>  12427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12427
agcaccacag cuagugagag                                                   20


<210>  12428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12428
cuuauccuug agccuccauu                                                   20


<210>  12429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12429
ccucccuuuu aaagauuagg                                                   20


<210>  12430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12430
cuacggcuca guggcagcag                                                   20


<210>  12431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12431
acagaacuuu cccuucaucu                                                   20


<210>  12432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12432
cugucugcag ugugaccugu                                                   20


<210>  12433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12433
gcagugugac cuguugguga                                                   20


<210>  12434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12434
cacugcagac agggacaaaa                                                   20


<210>  12435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12435
ccaacagguc acacugcaga                                                   20


<210>  12436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12436
uugcuccaaa ccacagcucc                                                   20


<210>  12437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12437
gagugugcug gguggcagga                                                   20


<210>  12438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12438
uuacucagcu caguauagcc                                                   20


<210>  12439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12439
aaggcucagg gaacaaggaa                                                   20


<210>  12440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12440
uacagccucu gcuuacucac                                                   20


<210>  12441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12441
aaaaauuauu uucugcuugc                                                   20


<210>  12442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12442
ugagaaacug aggcccagag                                                   20


<210>  12443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12443
ccccaggugc auuagaacug                                                   20


<210>  12444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12444
guucuggaaa cccaguucua                                                   20


<210>  12445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12445
uugaagcauu aguaggaguu                                                   20


<210>  12446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12446
ugagaauuuu auucuaggau                                                   20


<210>  12447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12447
acaguucuuu uucuuuuuuu                                                   20


<210>  12448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12448
cagcucacug caacaucugu                                                   20


<210>  12449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12449
cccggguuca agugguucuc                                                   20


<210>  12450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12450
caaacuccug accuccucag                                                   20


<210>  12451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12451
ggaguuugcg acuagccugg                                                   20


<210>  12452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12452
gaaauguaaa auguuacgaa                                                   20


<210>  12453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12453
ggugcuacca ucaaauaaau                                                   20


<210>  12454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12454
guucacguca ggugcuacca                                                   20


<210>  12455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12455
gcuuggaaga aucuggagcu                                                   20


<210>  12456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12456
acccccuuua cccaaagccu                                                   20


<210>  12457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12457
gaguagaaca gaguccaccc                                                   20


<210>  12458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12458
aagaugcaua uauacagaga                                                   20


<210>  12459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12459
aaacuccaug cuccuccuug                                                   20


<210>  12460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12460
gccugagagc aguuggagca                                                   20


<210>  12461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12461
gcuccaacug cucucaggca                                                   20


<210>  12462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12462
ccuccaaauc ucauguggaa                                                   20


<210>  12463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12463
ucaguguugg aaguggggcc                                                   20


<210>  12464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12464
ugggggagga accccuguga                                                   20


<210>  12465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12465
uugugauaau gaguaaguuc                                                   20


<210>  12466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12466
uuuuguguug cuauauaaag                                                   20


<210>  12467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12467
uaguccuuuu guguugcuau                                                   20


<210>  12468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12468
aggccacugu cuuaguccuu                                                   20


<210>  12469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12469
ucccuucugc cugcauuugu                                                   20


<210>  12470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12470
cucuugacuu ucccagcagg                                                   20


<210>  12471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12471
agagugacgg uuauauaaau                                                   20


<210>  12472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12472
uagguacugu ggucucuaca                                                   20


<210>  12473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12473
cuacaauaca gcagagguau                                                   20


<210>  12474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12474
cucaaccucu cggagccuca                                                   20


<210>  12475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12475
acgguuuccu ggcuccaaag                                                   20


<210>  12476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12476
gaauaaauug agggaaaaaa                                                   20


<210>  12477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12477
cuccuggugg cccugcccaa                                                   20


<210>  12478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12478
aguguggccc guaguuccca                                                   20


<210>  12479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12479
gcauuuggua acuucuuuau                                                   20


<210>  12480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12480
cuuuuguugu aauuuguaag                                                   20


<210>  12481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12481
ucauguuccu ccuugcaugg                                                   20


<210>  12482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12482
ccuccuucag caccaccacg                                                   20


<210>  12483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12483
gagcgcacug cccgccgccu                                                   20


<210>  12484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12484
uccauggccu ucuuccuggc                                                   20


<210>  12485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12485
ccacucaucu ucaccaggaa                                                   20


<210>  12486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12486
ccaguguaua ugcaguggcc                                                   20


<210>  12487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12487
ccuucugauu uucagcaaug                                                   20


<210>  12488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12488
aucuucauuu gaaagacgag                                                   20


<210>  12489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12489
uucaaaugaa gauagacgua                                                   20


<210>  12490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12490
ccucgucuuu caaaugaaga                                                   20


<210>  12491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12491
ccucugaacu ucagucuccu                                                   20


<210>  12492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12492
gugugguccc cucugaacuu                                                   20


<210>  12493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12493
gccugccagc cauucuugug                                                   20


<210>  12494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12494
cuacagguuu ccguaggcag                                                   20


<210>  12495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12495
uuuuauaaaa aagcaugacu                                                   20


<210>  12496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12496
ugcuuuuuua uaaaaugacu                                                   20


<210>  12497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12497
aaaauuccuu ugaagcuguu                                                   20


<210>  12498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12498
cuucuuuagg acaggguggc                                                   20


<210>  12499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12499
uaaagaaggg acuucacucu                                                   20


<210>  12500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12500
caucuucggu ggaggggcag                                                   20


<210>  12501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12501
ccuuucugcc ccuccaccga                                                   20


<210>  12502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12502
uuuucacacu gauucuccac                                                   20


<210>  12503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12503
gcaggaggcu aagaagcacc                                                   20


<210>  12504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12504
uguccaaggu cacacagcgu                                                   20


<210>  12505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12505
aaggucacac agcguguaau                                                   20


<210>  12506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12506
cacagcgugu aaugggcagg                                                   20


<210>  12507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12507
gagucuggag ucuggaccug                                                   20


<210>  12508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12508
ggagucugga ccugggucuc                                                   20


<210>  12509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12509
ggaccugggu cuccuagcug                                                   20


<210>  12510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12510
agacuccaga cucugacccu                                                   20


<210>  12511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12511
ccuagcugca cugcacugcu                                                   20


<210>  12512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12512
uggcgccaca ggccuuggua                                                   20


<210>  12513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12513
aucccuguca uggcgccaca                                                   20


<210>  12514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12514
cugccuugga aacccguagu                                                   20


<210>  12515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12515
aaguagagga gacugacaag                                                   20


<210>  12516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12516
ccucuacuua gacuacgggu                                                   20


<210>  12517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12517
gucuccucua cuuagacuac                                                   20


<210>  12518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12518
augccuucca ucagucugcu                                                   20


<210>  12519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12519
gcucaacaca cguuuaccaa                                                   20


<210>  12520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12520
ucuucgccuc ugcagcacac                                                   20


<210>  12521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12521
cuccuccuga acuguaagcu                                                   20


<210>  12522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12522
gucucuccuc cugaacugua                                                   20


<210>  12523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12523
cuggucaguc ucuccuccug                                                   20


<210>  12524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12524
acuguacugg cagucacugg                                                   20


<210>  12525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12525
cauagucaac uguacuggca                                                   20


<210>  12526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12526
cuccccaagg cugagcacau                                                   20


<210>  12527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12527
ucuggugcua uacggguacc                                                   20


<210>  12528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12528
agcucucgau ggcaaaugcc                                                   20


<210>  12529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12529
ugcccagccc cuuauuggcu                                                   20


<210>  12530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12530
aacccugagc aaaucccuuc                                                   20


<210>  12531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12531
uuaaaugaau guuccaauua                                                   20


<210>  12532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12532
ugaagcauuc agcagaugcu                                                   20


<210>  12533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12533
cuggaugccu ucguaucccc                                                   20


<210>  12534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12534
gaaggguaag gagagggaau                                                   20


<210>  12535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12535
ggagguaggg agggaguggg                                                   20


<210>  12536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12536
caaaaaaaaa aaaaaauggu                                                   20


<210>  12537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12537
gggcaacaga gucucaaaaa                                                   20


<210>  12538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12538
cagcuacucg ggaggcugag                                                   20


<210>  12539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12539
cgaacucucg accucaggug                                                   20


<210>  12540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12540
agaguucgag accagccugg                                                   20


<210>  12541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12541
ccgcucccag cugcugaugc                                                   20


<210>  12542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12542
uucuaacucc ugcuagugcc                                                   20


<210>  12543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12543
auucuccagc cuucuccagc                                                   20


<210>  12544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12544
ccuagucuau ucuccagccu                                                   20


<210>  12545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12545
ugauuuaggc auggagucca                                                   20


<210>  12546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12546
agggccugag cuucacucca                                                   20


<210>  12547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12547
auccugccca gagccuuggc                                                   20


<210>  12548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12548
gggagccagg cugugccaag                                                   20


<210>  12549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12549
aguucagaau ccuuccuaaa                                                   20


<210>  12550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12550
ggcauagagg auuccuuuua                                                   20


<210>  12551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12551
guccuccggg gcacuagcag                                                   20


<210>  12552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12552
uccggggcac uagcagggac                                                   20


<210>  12553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12553
cugcuagugc cccggaggac                                                   20


<210>  12554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12554
ccacauccca gcccagcagc                                                   20


<210>  12555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12555
aaauggcuua agcagagucc                                                   20


<210>  12556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12556
cccggccucu cuggcuucug                                                   20


<210>  12557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12557
acuacaucga ggaggacucc                                                   20


<210>  12558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12558
acauggggca acuucaaggc                                                   20


<210>  12559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12559
uccucgaugu agucgacaug                                                   20


<210>  12560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12560
uugcccagag caucccgugg                                                   20


<210>  12561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12561
uaccgggggg cugguauuca                                                   20


<210>  12562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12562
caaagccccc cgagaagugg                                                   20


<210>  12563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12563
guggaggugc ugagucccaa                                                   20


<210>  12564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12564
cauccccauc cccugcagcc                                                   20


<210>  12565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12565
ugccuuaaau gauccucuuu                                                   20


<210>  12566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12566
ccaucagaug aacccuccuu                                                   20


<210>  12567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12567
gcagggcacu gggaguuaua                                                   20


<210>  12568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12568
agucugcagg gcacugggag                                                   20


<210>  12569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12569
aucccauuaa aggaucuggu                                                   20


<210>  12570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12570
gggaugccuc ugccuaccuu                                                   20


<210>  12571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12571
ucccucuagg ccuuucuuuc                                                   20


<210>  12572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12572
gcauucuagc agggacuugc                                                   20


<210>  12573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12573
cugcuagaau gcagaccguu                                                   20


<210>  12574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12574
gggaagacuc uagaugcacc                                                   20


<210>  12575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12575
uccccgacug aauugccacc                                                   20


<210>  12576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12576
aacuagaacc cuucauucuc                                                   20


<210>  12577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12577
ggagcucagc gcagagauga                                                   20


<210>  12578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12578
augcaacaug gugccaggac                                                   20


<210>  12579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12579
uggcaccaug uugcauggac                                                   20


<210>  12580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12580
uucuugucug uaaaaugggc                                                   20


<210>  12581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12581
guaaaauggg cacauaaccc                                                   20


<210>  12582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12582
cuguccuucu cacagguugc                                                   20


<210>  12583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12583
uucucacagg uugcugugag                                                   20


<210>  12584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12584
cacagcaacc ugugagaagg                                                   20


<210>  12585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12585
cacaguagcc ccccaacuuu                                                   20


<210>  12586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12586
cacaguuugg guguaugcaa                                                   20


<210>  12587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12587
gaguugcugc cauugcaaca                                                   20


<210>  12588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12588
cccacacaaa cccuuucucc                                                   20


<210>  12589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12589
gucaugugug cugacccggc                                                   20


<210>  12590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12590
ugugugcuga cccggccugg                                                   20


<210>  12591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12591
gcacacauga ccgaccaggc                                                   20


<210>  12592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12592
ucucccuggc cacaggcugc                                                   20


<210>  12593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12593
caccugguug gaaaggaaca                                                   20


<210>  12594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12594
cugaggcacu gauguggagu                                                   20


<210>  12595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12595
cugauauuag ccugcuccgg                                                   20


<210>  12596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12596
cucuuggucu cugauauuag                                                   20


<210>  12597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12597
cugugauccu cugccagugu                                                   20


<210>  12598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12598
aggcagggac ugagaagauc                                                   20


<210>  12599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12599
cugccuggac uggggucucu                                                   20


<210>  12600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12600
cagcagugcu aggaaacuaa                                                   20


<210>  12601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12601
uggaggccag aagccugaau                                                   20


<210>  12602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12602
gcaggaccac uuucucccgg                                                   20


<210>  12603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12603
ugccgacacu gauucaggcu                                                   20


<210>  12604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12604
caacagcggc agcacaccaa                                                   20


<210>  12605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12605
ucacacagcc uucucugugu                                                   20


<210>  12606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12606
cucuccucuu cauugucuca                                                   20


<210>  12607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12607
cauaaggaca cuugucauug                                                   20


<210>  12608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12608
uuaugagaca augaagagga                                                   20


<210>  12609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12609
uuggauuuag ggcccacugg                                                   20


<210>  12610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12610
uugcagaugu gguuaagguu                                                   20


<210>  12611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12611
cagccacagg uugugggggu                                                   20


<210>  12612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12612
gcuucuggcc caagggagag                                                   20


<210>  12613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12613
gugggaggug gcaggaaugg                                                   20


<210>  12614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12614
uaucaagggc uuggcuggag                                                   20


<210>  12615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12615
uccuggagcu guugggcugg                                                   20


<210>  12616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12616
ggguuugagg gcggcagcca                                                   20


<210>  12617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12617
cacaguuaag agugcagggu                                                   20


<210>  12618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12618
cucacccucu cugaucuuca                                                   20


<210>  12619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12619
gguauugagu gaggugcugu                                                   20


<210>  12620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12620
cuucccccaa caguguaucc                                                   20


<210>  12621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12621
aguagcauuu guuuaaggaa                                                   20


<210>  12622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12622
uggcuagaac agcgcuuccu                                                   20


<210>  12623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12623
ccuuugccug guuaauaaug                                                   20


<210>  12624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12624
aagcagugga augaacgugg                                                   20


<210>  12625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12625
cuucugcaca ggccacacuc                                                   20


<210>  12626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12626
caccagccuc ggucccuucu                                                   20


<210>  12627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12627
gaugugaaag gaagaacuug                                                   20


<210>  12628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12628
gagcuucuca ggcguauggc                                                   20


<210>  12629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12629
ugcuugcaua ccuccagagc                                                   20


<210>  12630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12630
cagggaacua gcagccccug                                                   20


<210>  12631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12631
cauccgagcu gggccccuuu                                                   20


<210>  12632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12632
ggaggcugca agcauggcca                                                   20


<210>  12633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12633
cagcaggaca gugggcuggu                                                   20


<210>  12634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12634
ugcugggaca gggucaggag                                                   20


<210>  12635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12635
caucccuggg ccuggggugu                                                   20


<210>  12636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12636
caucaucuug cagcagaacc                                                   20


<210>  12637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12637
caagcacggg ugggaccaga                                                   20


<210>  12638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12638
cacccgugcu ugggaccacc                                                   20


<210>  12639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12639
uuucuggucc cacccgugcu                                                   20


<210>  12640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12640
ugugugagga gggaacugag                                                   20


<210>  12641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12641
auguuccucg ucguguguga                                                   20


<210>  12642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12642
agggagggaa gcagccucug                                                   20


<210>  12643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12643
ucuagauaag ccuguauucc                                                   20


<210>  12644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12644
gccaauguau ccaguugucc                                                   20


<210>  12645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12645
cgucagccug gaagcucuga                                                   20


<210>  12646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12646
gccuggaagc ucugagggaa                                                   20


<210>  12647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12647
gcuccuagca gaggccccgg                                                   20


<210>  12648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12648
ugugucugcc ccuucgacau                                                   20


<210>  12649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12649
gccccuucga cauuccauag                                                   20


<210>  12650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12650
aaggggcaga cacaagacaa                                                   20


<210>  12651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12651
ccagaugucu ucaggucgga                                                   20


<210>  12652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12652
ucaggucgga gcucacagcg                                                   20


<210>  12653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12653
gagcucacag cgcucucagc                                                   20


<210>  12654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12654
uugcucucug aguguguuag                                                   20


<210>  12655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12655
gccucuccuc ccaggcugug                                                   20


<210>  12656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12656
uuggcagucu gccucuccuc                                                   20


<210>  12657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12657
cgugggcacu uugguuucuu                                                   20


<210>  12658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12658
cggcaggaag cuccacugau                                                   20


<210>  12659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12659
acccugcccu aaggccucca                                                   20


<210>  12660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12660
ccagccugca cacacacugu                                                   20


<210>  12661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12661
gaacugugag uccccagccu                                                   20


<210>  12662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12662
gggcacaguc cgaacuguga                                                   20


<210>  12663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12663
cgcauccucc cacccaccca                                                   20


<210>  12664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12664
gcccccaguc ccgcauccuc                                                   20


<210>  12665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12665
gggugugugu aucugugggg                                                   20


<210>  12666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12666
ggcucacagg cucugucugg                                                   20


<210>  12667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12667
uuguagaugu aauuaagcau                                                   20


<210>  12668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12668
ugugaugugu cuuuaugaga                                                   20


<210>  12669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12669
uuaugagaga aaggcagagg                                                   20


<210>  12670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12670
aaucucccuc ugccuuucuc                                                   20


<210>  12671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12671
ccacguggcc ccuccugugu                                                   20


<210>  12672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12672
uccggcuucu gguggcugcu                                                   20


<210>  12673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12673
gggaauuugu gaccgaagcc                                                   20


<210>  12674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12674
caaauuccca gacucagcag                                                   20


<210>  12675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12675
ugagaugaga aucucuacuc                                                   20


<210>  12676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12676
ucugaagugc caucugaaca                                                   20


<210>  12677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12677
ccugagucuu cugaagugcc                                                   20


<210>  12678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12678
aacugcuccu gccccagggu                                                   20


<210>  12679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12679
gucaaacugc uccugcccca                                                   20


<210>  12680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12680
ugcgccagcg gaaauggccu                                                   20


<210>  12681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12681
uccuuuggcc uggcugagag                                                   20


<210>  12682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12682
cagaaacucu cagccaggcc                                                   20


<210>  12683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12683
agccugcugg auggagaagg                                                   20


<210>  12684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12684
ugcaugggcg acucccccag                                                   20


<210>  12685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12685
cccaugcagg acaaagguua                                                   20


<210>  12686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12686
cuugcagcuu uuaccccagu                                                   20


<210>  12687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12687
ccgagcgccu acccuacacu                                                   20


<210>  12688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12688
caaccucaga gaaaacaguc                                                   20


<210>  12689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12689
ccgugagccc uccugguauc                                                   20


<210>  12690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12690
aagcguucuc cacuccacaa                                                   20


<210>  12691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12691
gggccuccug gcuccagguc                                                   20


<210>  12692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12692
gagcugcagc uuccugucuc                                                   20


<210>  12693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12693
cuaaaaugag ccggccagcg                                                   20


<210>  12694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12694
ggccaccugc gcuggccggc                                                   20


<210>  12695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12695
uuaaaucuug uugucuuucu                                                   20


<210>  12696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12696
uucuugcaga cucggugagc                                                   20


<210>  12697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12697
gcaagaaaga caacaagauu                                                   20


<210>  12698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12698
uccugcuccu ucauaugaau                                                   20


<210>  12699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12699
uucuuggcag uagcauugcc                                                   20


<210>  12700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12700
aaggccauca gcuggcaaug                                                   20


<210>  12701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12701
augaaauaca uuauagaaua                                                   20


<210>  12702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12702
accuuauagu uaacacacag                                                   20


<210>  12703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12703
ccuuggaaag acggaggcag                                                   20


<210>  12704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12704
uuccaaggcg acauuugugg                                                   20


<210>  12705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12705
aggagauaca ccuccaccag                                                   20


<210>  12706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12706
cucuguaugc uggugucuag                                                   20


<210>  12707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12707
uggucaccga cuucgagaau                                                   20


<210>  12708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12708
ccgacuucga gaaugugccc                                                   20


<210>  12709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12709
gugaccauga cccugcccuc                                                   20


<210>  12710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12710
uccucgggca cauucucgaa                                                   20


<210>  12711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12711
cguccuccuc gggcacauuc                                                   20


<210>  12712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12712
guggaagcgg gucccguccu                                                   20


<210>  12713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12713
gaugggaggg cugccucugc                                                   20


<210>  12714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12714
ccacccaccu ccaggauggg                                                   20


<210>  12715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12715
cuguccccuc ccugccauca                                                   20


<210>  12716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12716
ccucccugcc aucaguugug                                                   20


<210>  12717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12717
uucucaugug guccuugugu                                                   20


<210>  12718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12718
uuguguucgu cgagcaggcc                                                   20


<210>  12719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12719
agcaggccag caagugugac                                                   20


<210>  12720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12720
cacuugcugg ccugcucgac                                                   20


<210>  12721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12721
uggcacccac cuggcagggg                                                   20


<210>  12722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12722
gcggccggga ugccggcgug                                                   20


<210>  12723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12723
ggggccauca cuuaccuaug                                                   20


<210>  12724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12724
cucuccaucu ggaccuggcc                                                   20


<210>  12725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12725
agauggagag agaccagcgu                                                   20


<210>  12726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12726
ccuaaccaag aaugcugugg                                                   20


<210>  12727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12727
ugcagguagc ccagggaguu                                                   20


<210>  12728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12728
aggcugaacu cccugggcua                                                   20


<210>  12729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12729
augaccuuuc cacaguucca                                                   20


<210>  12730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12730
uugacccagg gucaaggcug                                                   20


<210>  12731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12731
uuaugucuuu uguuauguua                                                   20


<210>  12732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12732
uuuguuaugu uaucuucaau                                                   20


<210>  12733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12733
cuccacauug aagauaacau                                                   20


<210>  12734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12734
cagagguaug caagcagaag                                                   20


<210>  12735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12735
ccuggucuca gagguaugca                                                   20


<210>  12736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12736
ugcaagugag ugaguccccu                                                   20


<210>  12737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12737
cacuggccag gcagaugugg                                                   20


<210>  12738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12738
ucugccaguu ccuccaccac                                                   20


<210>  12739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12739
agaaaaaguc cucugccagu                                                   20


<210>  12740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12740
cagucuagaa aaaguccucu                                                   20


<210>  12741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12741
acccagcggc cccccuauga                                                   20


<210>  12742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12742
aguugagaac uaggacucug                                                   20


<210>  12743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12743
uaguucucaa cuggacuuca                                                   20


<210>  12744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12744
accggccccc agaguccuag                                                   20


<210>  12745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12745
guaagggaga gaacccuccc                                                   20


<210>  12746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12746
ggccacagaa ggaagucagu                                                   20


<210>  12747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12747
uggggcuggc cuugccguag                                                   20


<210>  12748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12748
acuauuuagc agcuacggca                                                   20


<210>  12749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12749
agagagggga ggugacugcc                                                   20


<210>  12750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12750
ccuccccucu cuggacuggu                                                   20


<210>  12751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12751
cacagcucaa gcuggggaac                                                   20


<210>  12752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12752
gcucugggca gcagcuugac                                                   20


<210>  12753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12753
agcugcugcc cagagcugac                                                   20


<210>  12754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12754
aacacuggcu cuggugcugg                                                   20


<210>  12755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12755
gcccugugcu ccaccaguuc                                                   20


<210>  12756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12756
cagggcagaa cugguggagc                                                   20


<210>  12757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12757
ccugaugggg cagaagguua                                                   20


<210>  12758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12758
caccccuuua uugacugacc                                                   20


<210>  12759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12759
auaaaggggu gggacaggca                                                   20


<210>  12760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12760
gucaauaaag gggugggaca                                                   20


<210>  12761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12761
ggucaguucc ugaaggucag                                                   20


<210>  12762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12762
guuccugaag gucagugugu                                                   20


<210>  12763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12763
guguguggag gggaggcugu                                                   20


<210>  12764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12764
uccagaggcc agagcaccag                                                   20


<210>  12765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12765
cuucuuuggg gucccaguca                                                   20


<210>  12766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12766
cagucagugu augggaagcc                                                   20


<210>  12767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12767
guguauggga agcccuuauu                                                   20


<210>  12768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12768
ugcaauaagg gcuucccaua                                                   20


<210>  12769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12769
cuauugccuu ccuugccacu                                                   20


<210>  12770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12770
agucugagca cagagauaag                                                   20


<210>  12771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12771
gagcacagag auaagcacac                                                   20


<210>  12772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12772
ggaguucgag accagccugu                                                   20


<210>  12773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12773
cgaacuccug accucaggug                                                   20


<210>  12774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12774
cuacuaaaaa uacaaaaauu                                                   20


<210>  12775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12775
guaucccagc uacuugggag                                                   20


<210>  12776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12776
ccuaggagga gcauggcugu                                                   20


<210>  12777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12777
ccaggagccg uggccaagga                                                   20


<210>  12778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12778
aaugaggugu gggagccuuc                                                   20


<210>  12779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12779
guuccagguc cccuugcaca                                                   20


<210>  12780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12780
ccuugcacau cagggccaga                                                   20


<210>  12781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12781
ccaggccacu gggccagagc                                                   20


<210>  12782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12782
ggacaucgag accauccuug                                                   20


<210>  12783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12783
ugaccucaug auccucccgc                                                   20


<210>  12784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12784
cgauguccug accucaugau                                                   20


<210>  12785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12785
cuacuaaaac uacaaaaaau                                                   20


<210>  12786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12786
cagcuacuca ggaggcugag                                                   20


<210>  12787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12787
cgcucuauug cccaggcugg                                                   20


<210>  12788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12788
ggaaagaaaa aaaaaaaaaa                                                   20


<210>  12789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12789
acaguaacag cucuuuuuuu                                                   20


<210>  12790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12790
accucaugcu acugucaaca                                                   20


<210>  12791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12791
uaggcaugga gucuuuuaau                                                   20


<210>  12792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12792
uuuaauucuu uagacaaucc                                                   20


<210>  12793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12793
aaagaauuaa aagacuccau                                                   20


<210>  12794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12794
cuguuucaca gagggcgggg                                                   20


<210>  12795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12795
uggcugccca cucaccagcu                                                   20


<210>  12796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12796
aacacuugcg gccacggugg                                                   20


<210>  12797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12797
gaauauacga acucagggga                                                   20


<210>  12798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12798
aagcgucuga auauacgaac                                                   20


<210>  12799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12799
agguucugca gagaagcaga                                                   20


<210>  12800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12800
caugagcuug aaacucuuaa                                                   20


<210>  12801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12801
gaaauccgca gggcaggcca                                                   20


<210>  12802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12802
uaaggcaguc cuggggcaga                                                   20


<210>  12803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12803
uggggcagaa uuccuucuuc                                                   20


<210>  12804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12804
guucucuuaa ggccuucaac                                                   20


<210>  12805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12805
ucugauuuaa auguuaguca                                                   20


<210>  12806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12806
caucuaaaaa auauuuucgc                                                   20


<210>  12807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12807
aaagccagug gaaaugcugc                                                   20


<210>  12808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12808
ccccaagggg ugaccuuggc                                                   20


<210>  12809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12809
ccccuugggg agaccugcuc                                                   20


<210>  12810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12810
agccuguggg gccacuggug                                                   20


<210>  12811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12811
ucaacgccgc cugccagcgc                                                   20


<210>  12812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12812
ugcuggucac cgcugccggc                                                   20


<210>  12813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12813
ccgcugccgg caacuuccgg                                                   20


<210>  12814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12814
cggaaguugc cggcagcggu                                                   20


<210>  12815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12815
ucagagaccc ccgccaugcg                                                   20


<210>  12816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12816
gagacccccg ccaugcggga                                                   20


<210>  12817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12817
cugacgacuc cuuccaaagc                                                   20


<210>  12818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12818
gaauagcagu ggccccgcca                                                   20


<210>  12819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12819
uggccacucu cccuccugaa                                                   20


<210>  12820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12820
ucugguaccc gcccccuccc                                                   20


<210>  12821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12821
ucugcccaau acucuuuggg                                                   20


<210>  12822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12822
agcucucucc gcggcuccau                                                   20


<210>  12823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12823
uggagccgcg gagagagcug                                                   20


<210>  12824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12824
gucauggagc cgcggagaga                                                   20


<210>  12825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12825
gagcccucaa ccgcucccau                                                   20


<210>  12826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12826
ccgcagccac acugcaccgg                                                   20


<210>  12827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12827
guguccccgc agccacacug                                                   20


<210>  12828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12828
cugcccccca gcuccucagg                                                   20


<210>  12829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12829
cuccucugac ccaccacucc                                                   20


<210>  12830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12830
gaggagggac ggucacugcc                                                   20


<210>  12831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12831
ggacacugcg gguaucuagg                                                   20


<210>  12832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12832
ugacacugga ggaguggugg                                                   20


<210>  12833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12833
ggaacuucaa gucugugugu                                                   20


<210>  12834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12834
gugugugugc gugcgcgcgc                                                   20


<210>  12835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12835
gguacgcauc ugcucugcaa                                                   20


<210>  12836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12836
ccccuggccu aucaaggcuu                                                   20


<210>  12837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12837
ucucaguuuc cccccguggc                                                   20


<210>  12838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12838
cuaccauagc caggcagcau                                                   20


<210>  12839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12839
gauuuuccuu aggaggggac                                                   20


<210>  12840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12840
ccuccuaagg aaaaucugac                                                   20


<210>  12841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12841
cacucaaaug uccccuccua                                                   20


<210>  12842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12842
agcccagcug gcaaggccug                                                   20


<210>  12843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12843
gccucugcaa ccccucucuu                                                   20


<210>  12844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12844
ucacaguugg ggccaccaau                                                   20


<210>  12845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12845
ugggcauugg uggccccaac                                                   20


<210>  12846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12846
ccggcugguc uugggcauug                                                   20


<210>  12847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12847
ccagggucac cggcuggucu                                                   20


<210>  12848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12848
ccaaaguccc cagggucacc                                                   20


<210>  12849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12849
acacagcggc caaaguuggu                                                   20


<210>  12850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12850
uccccugggg caaagagguc                                                   20


<210>  12851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12851
cuggaggcac caaugauguc                                                   20


<210>  12852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12852
cagaguggga caucacaggc                                                   20


<210>  12853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12853
cacucuguga cacaaagcag                                                   20


<210>  12854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12854
ccaccccacu gccucggcca                                                   20


<210>  12855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12855
gggucugugc cgggaccucc                                                   20


<210>  12856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12856
gugccgggac cuccagugcc                                                   20


<210>  12857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12857
cggcacagac ccugacugcc                                                   20


<210>  12858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12858
cccugcacag agccuggcac                                                   20


<210>  12859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12859
uugaaggcac caucaggccu                                                   20


<210>  12860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12860
gaugagggag gcgagugcac                                                   20


<210>  12861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12861
gggcuguauu agagggagcc                                                   20


<210>  12862
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12862
gagaaggcau cuuggaggag                                                   20


<210>  12863
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12863
cuccuccaag augccuucuc                                                   20


<210>  12864
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12864
uaucggccag gugaacuccu                                                   20


<210>  12865
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12865
uaccucacug aguaaggacu                                                   20


<210>  12866
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12866
uuacucagug agguaagaca                                                   20


<210>  12867
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12867
gugugcacgu guguuugugu                                                   20


<210>  12868
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12868
ccugcugggg caggagggcc                                                   20


<210>  12869
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12869
gccgagccgg agcucacccu                                                   20


<210>  12870
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12870
cugccucaac ucggccaggg                                                   20


<210>  12871
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12871
ucaaugaggc cugguucccu                                                   20


<210>  12872
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12872
ucagggaacc aggccucauu                                                   20


<210>  12873
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12873
guacccgcug guccucaggg                                                   20


<210>  12874
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12874
aggcuggggc uugggagguc                                                   20


<210>  12875
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12875
gugugaccuu gacagucucu                                                   20


<210>  12876
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12876
cacagaccuc ccaagcccca                                                   20


<210>  12877
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12877
aggucacaca gaccucccaa                                                   20


<210>  12878
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12878
cucccuucuc ccuugucugu                                                   20


<210>  12879
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12879
guguaaggag gaugacgcca                                                   20


<210>  12880
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12880
uccuccuuac acagacaagg                                                   20


<210>  12881
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12881
cuauaaaaac acguuaugaa                                                   20


<210>  12882
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12882
ccucacuccc agcacccccu                                                   20


<210>  12883
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12883
ugcaaaacag cugccaaccu                                                   20


<210>  12884
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12884
gcacacucgg ggccuacacg                                                   20


<210>  12885
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12885
cccgcugcgc cccagaugag                                                   20


<210>  12886
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12886
ccuccaugcg cucgccccgc                                                   20


<210>  12887
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12887
gugcugggcc cucagggacc                                                   20


<210>  12888
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12888
cugagggccc agcacugaca                                                   20


<210>  12889
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12889
ggaggaugga ggggcuugcu                                                   20


<210>  12890
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12890
ggccagcccu guaagcuuac                                                   20


<210>  12891
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12891
ugcagccucu aggaaacccu                                                   20


<210>  12892
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12892
gcgaucugcu acucuggacu                                                   20


<210>  12893
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12893
agaguagcag aucgcugacc                                                   20


<210>  12894
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12894
uaaugcucgu gugagaggca                                                   20


<210>  12895
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12895
uccuugggca ggagugagcu                                                   20


<210>  12896
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12896
ccagaaggcu gggucuggcu                                                   20


<210>  12897
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12897
ggcuggcccc uggcagggac                                                   20


<210>  12898
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12898
cugccagggg ccagccagac                                                   20


<210>  12899
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12899
agucccuuuc uguguuuuca                                                   20


<210>  12900
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12900
cuuucugugu uuucaaagcc                                                   20


<210>  12901
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12901
uugacucuaa ggcccaaggg                                                   20


<210>  12902
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12902
aagacggaaa ugggaaucug                                                   20


<210>  12903
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12903
gccgggccca caacgcuuuu                                                   20


<210>  12904
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12904
acgccauugc caggugcugc                                                   20


<210>  12905
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12905
acacagcucc accagcugag                                                   20


<210>  12906
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12906
ccaugcuggc cucagcuggu                                                   20


<210>  12907
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12907
acugccacca acagggccac                                                   20


<210>  12908
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12908
ucacagguag gaggcugggc                                                   20


<210>  12909
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12909
cuuucuccuu augcacccac                                                   20


<210>  12910
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12910
ucacaagugu gauccaugag                                                   20


<210>  12911
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12911
cauggaucac acuugugagg                                                   20


<210>  12912
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12912
ggcuugaguc ucauggauca                                                   20


<210>  12913
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12913
ccugcccagg cucaaagggc                                                   20


<210>  12914
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12914
aggagaggca gcuccagaga                                                   20


<210>  12915
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12915
gcccuccuuu cagccccagc                                                   20


<210>  12916
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12916
cacagcuaua gagcggcagg                                                   20


<210>  12917
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12917
cggcacuaag cuaagugcuu                                                   20


<210>  12918
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12918
auaguugccu auaccagagg                                                   20


<210>  12919
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12919
aaaacaugcc caggcaggua                                                   20


<210>  12920
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12920
cagaugggga ccucuugggg                                                   20


<210>  12921
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12921
ccaucuguga cuuccugcua                                                   20


<210>  12922
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12922
gggaagacag ugggacucca                                                   20


<210>  12923
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12923
ucccagaccu cucaugcucc                                                   20


<210>  12924
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12924
cacugucuuc ccagaccucu                                                   20


<210>  12925
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12925
gagcacgucc aggggaacca                                                   20


<210>  12926
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12926
aggggaacca cugaggguuu                                                   20


<210>  12927
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12927
gguggcuggu gcccuugucc                                                   20


<210>  12928
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12928
aggggagagg cuccgucagg                                                   20


<210>  12929
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12929
gguucagggg uccuggcuug                                                   20


<210>  12930
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12930
uggcuuggag ggaaguccgc                                                   20


<210>  12931
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12931
gccaugcucu aaucacgcuc                                                   20


<210>  12932
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12932
guuugaaguc auggaaucug                                                   20


<210>  12933
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12933
uggaaucuga cuccaugaag                                                   20


<210>  12934
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12934
gauuccauga cuucaaacug                                                   20


<210>  12935
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12935
agccugcagu ucccuuagcu                                                   20


<210>  12936
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12936
uagcugcaag ggcucggggc                                                   20


<210>  12937
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12937
ucuucacagu gucccuguga                                                   20


<210>  12938
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12938
cugugaguag gugugguuuc                                                   20


<210>  12939
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12939
gacuccuaag cccauggagg                                                   20


<210>  12940
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12940
gacacaccca uuggcuaaga                                                   20


<210>  12941
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12941
gaaccaccuc agaaugcccu                                                   20


<210>  12942
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12942
gucugaacca ccucagaaug                                                   20


<210>  12943
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12943
ccaucucugg guggaaagau                                                   20


<210>  12944
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12944
cacagcuggu cagcugcaga                                                   20


<210>  12945
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12945
gcugcagagu ugagaacaca                                                   20


<210>  12946
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12946
uggugcucag gccagcaucu                                                   20


<210>  12947
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12947
gaggcaagag cuaggaaacc                                                   20


<210>  12948
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12948
gauggggaug ggcacuggag                                                   20


<210>  12949
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12949
ccagugccca uccccaucag                                                   20


<210>  12950
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12950
uccaccuccc agugggagcu                                                   20


<210>  12951
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12951
gcccaaccag ugcgugggcc                                                   20


<210>  12952
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12952
ggaaugcaaa gucaaggagc                                                   20


<210>  12953
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12953
aggagcaugg aaucccggcc                                                   20


<210>  12954
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12954
cuccugcaca gcuuuucugu                                                   20


<210>  12955
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12955
guuugugcca ccaccauacc                                                   20


<210>  12956
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12956
acacaauggc ggaagcugcc                                                   20


<210>  12957
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12957
cuguguggcu gggucuguuu                                                   20


<210>  12958
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12958
guuuuugcuu uuguccagau                                                   20


<210>  12959
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12959
agaucaguaa gguuugcuac                                                   20


<210>  12960
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12960
ugcuguguug cccaggcugg                                                   20


<210>  12961
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12961
caaauuccug ggcucaagca                                                   20


<210>  12962
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12962
cagccucccc aaguguuggg                                                   20


<210>  12963
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12963
cagggucagg agcagcacug                                                   20


<210>  12964
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12964
ggagcagcac ugggcucuga                                                   20


<210>  12965
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12965
ucagagccca gugcugcucc                                                   20


<210>  12966
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12966
cggcugagug agcucugugu                                                   20


<210>  12967
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12967
ugcuaacaac cuucagcaug                                                   20


<210>  12968
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12968
cauuccaggg cuuggcacau                                                   20


<210>  12969
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12969
acucuuaaau gaacucagag                                                   20


<210>  12970
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12970
guuuuaaaau gcaagucugu                                                   20


<210>  12971
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12971
guguugauuc uggucuggau                                                   20


<210>  12972
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12972
ggauggugca uuccucgaga                                                   20


<210>  12973
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12973
uuugcucucg aggaaugcac                                                   20


<210>  12974
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12974
uggucuugga uccacuugcc                                                   20


<210>  12975
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12975
uggauccacu ugcccugggu                                                   20


<210>  12976
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12976
cuugggccug uaucccuccc                                                   20


<210>  12977
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12977
uccuccacua aaauagaugc                                                   20


<210>  12978
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12978
ggagaggucu cgcugacaag                                                   20


<210>  12979
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12979
cgcugacaag guggacgaaa                                                   20


<210>  12980
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12980
gcgagaccuc uccugaccuc                                                   20


<210>  12981
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12981
accuugucag cgagaccucu                                                   20


<210>  12982
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12982
ccucugaggc accccccauc                                                   20


<210>  12983
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12983
ggugagaccu gagggucaca                                                   20


<210>  12984
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12984
caccugacuu ggcccugucc                                                   20


<210>  12985
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12985
cagucagcag ugagcugggg                                                   20


<210>  12986
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12986
gcagugagcu ggggccaugc                                                   20


<210>  12987
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12987
ggccucagag gagugugguc                                                   20


<210>  12988
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12988
ggccuggauc ugaaccucuc                                                   20


<210>  12989
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12989
ucucuucuca gcucagcagc                                                   20


<210>  12990
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12990
uugucaucuc uucucagcuc                                                   20


<210>  12991
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12991
cccugcuucu gcccaagguc                                                   20


<210>  12992
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12992
aggcguuggg gcggggcuca                                                   20


<210>  12993
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12993
gaagggagcc ugcaggccug                                                   20


<210>  12994
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12994
aggggcccga gccuuggugc                                                   20


<210>  12995
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12995
aucuccacgg cccucaaacc                                                   20


<210>  12996
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12996
gccauggugc agaaccgccu                                                   20


<210>  12997
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12997
caaaugggcu cugagccagc                                                   20


<210>  12998
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12998
gcacuuuggc cucacagaag                                                   20


<210>  12999
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  12999
gagggagaaa ugaagugugg                                                   20


<210>  13000
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13000
cgggccacgc uagacaugug                                                   20


<210>  13001
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13001
agcguggccc gggaccccca                                                   20


<210>  13002
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13002
ccugccagag cccgaggaaa                                                   20


<210>  13003
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13003
agcccuccuc gcaggccacg                                                   20


<210>  13004
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13004
ggguccagcc cuccucgcag                                                   20


<210>  13005
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13005
cagggagggc acugcagcca                                                   20


<210>  13006
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13006
ugggggccua cgccguagac                                                   20


<210>  13007
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13007
acggcguagg cccccaggac                                                   20


<210>  13008
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13008
ggagccggga cgucagcacu                                                   20


<210>  13009
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13009
cggcuccuga cuacacacgu                                                   20


<210>  13010
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13010
gcacuacagg cagcaccagc                                                   20


<210>  13011
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13011
cggccccuuc gcuggugcug                                                   20


<210>  13012
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13012
cuggagcucc ugggaggccu                                                   20


<210>  13013
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13013
ggggaggguc aagggcuggg                                                   20


<210>  13014
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13014
agggcugggg cugagcuuua                                                   20


<210>  13015
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13015
gaaccauuuu aaagcucagc                                                   20


<210>  13016
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13016
cucucucagc ccuccauggc                                                   20


<210>  13017
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13017
agcugugcuc gggugcugcc                                                   20


<210>  13018
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13018
gugggcagaa ugacuuuuau                                                   20


<210>  13019
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13019
uucugcccac ggacaucggc                                                   20


<210>  13020
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13020
ccaccaagga ggcaggauuc                                                   20


<210>  13021
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13021
cugcagcccc uaccgccccc                                                   20


<210>  13022
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13022
ccagccucug gcuagaugcc                                                   20


<210>  13023
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13023
caggcugugc cuugguuucc                                                   20


<210>  13024
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13024
uaggugaugg cuccccgcag                                                   20


<210>  13025
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13025
guccuaggug auggcucccc                                                   20


<210>  13026
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13026
cagccaaccc gcuccacuac                                                   20


<210>  13027
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13027
guguuccccu ucccagccuc                                                   20


<210>  13028
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13028
ggggagaggg ccaacaacug                                                   20


<210>  13029
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13029
cuccuugagc accagcccca                                                   20


<210>  13030
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13030
gcuugcuugg guggggcugg                                                   20


<210>  13031
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13031
guccucucug uugccuuuuu                                                   20


<210>  13032
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13032
ucucuguugc cuuuuuacag                                                   20


<210>  13033
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13033
agaaaaguug gcuguaaaaa                                                   20


<210>  13034
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13034
ccauauuaau aaaaaugcua                                                   20


<210>  13035
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13035
uaacucuugc auagacuuga                                                   20


<210>  13036
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13036
augcaagagu uaggacaacg                                                   20


<210>  13037
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13037
agucuaugca agaguuagga                                                   20


<210>  13038
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13038
uccugcagcu ccccugacca                                                   20


<210>  13039
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13039
ggggagcugc aggaagacau                                                   20


<210>  13040
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13040
ggguggucag gggagcugca                                                   20


<210>  13041
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13041
aagugccucc uccuugguga                                                   20


<210>  13042
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13042
ccaaggagga ggcacuuuga                                                   20


<210>  13043
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13043
ugaccuccca augcccuuuu                                                   20


<210>  13044
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13044
ggacaacaga gcaucuagag                                                   20


<210>  13045
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13045
auggcuuuuu ucaugauuua                                                   20


<210>  13046
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13046
cagauugggu gcaauggcuc                                                   20


<210>  13047
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13047
ugaauuccua aacacaagca                                                   20


<210>  13048
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13048
cacuguugcc cagggucuug                                                   20


<210>  13049
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13049
cuauaaaaaa auuuaaaaga                                                   20


<210>  13050
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13050
cggcuacuca ggaggcugau                                                   20


<210>  13051
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13051
cacauugaau gggaucauua                                                   20


<210>  13052
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13052
uaagcaaguu cucucucucu                                                   20


<210>  13053
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13053
agagagagag agaacuugcu                                                   20


<210>  13054
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13054
uaaggaaucu caggcaaaau                                                   20


<210>  13055
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13055
gaaaauguaa ucugggagga                                                   20


<210>  13056
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13056
uauauggaaa gcauucaaga                                                   20


<210>  13057
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13057
acucuugaau gcuuuccaua                                                   20


<210>  13058
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13058
aggguugcac cacaggccua                                                   20


<210>  13059
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13059
ggguguggau cucuaaccag                                                   20


<210>  13060
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13060
ccagggaucg gggaggaagg                                                   20


<210>  13061
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13061
agauuuucgc cuuccugcaa                                                   20


<210>  13062
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13062
ccuucccuau uugcuagucc                                                   20


<210>  13063
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13063
cauuccuagu ggccagcguu                                                   20


<210>  13064
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13064
cagucucauu ccuaguggcc                                                   20


<210>  13065
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13065
cacugggcuu cuugcuagau                                                   20


<210>  13066
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13066
cuggucacac ugggcuucuu                                                   20


<210>  13067
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13067
ccagcauaga ucgugucgcu                                                   20


<210>  13068
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13068
ccauucaucu ccaccaaagc                                                   20


<210>  13069
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13069
gccccuccag agaaaagaac                                                   20


<210>  13070
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13070
ucugagccug uugcuguucu                                                   20


<210>  13071
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13071
ccuuuauuag uguaaaguac                                                   20


<210>  13072
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13072
ugccgccauu cuucauauau                                                   20


<210>  13073
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13073
gcuuguucca agcucagaag                                                   20


<210>  13074
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13074
ugccccaccu ucccugcuaa                                                   20


<210>  13075
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13075
gaugauacgg cacucuaguu                                                   20


<210>  13076
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13076
guuuuaggaa cuagagugcc                                                   20


<210>  13077
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13077
gugaccgugu gaggacucca                                                   20


<210>  13078
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13078
cugacaacua cagucaguuu                                                   20


<210>  13079
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13079
ucacacgguc acugacaacu                                                   20


<210>  13080
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13080
uggugagaug cccgcuggga                                                   20


<210>  13081
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13081
gcaaacagag caggaauugc                                                   20


<210>  13082
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13082
uuuuuacugc caauuuuuug                                                   20


<210>  13083
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13083
uaacugucac uguuguacua                                                   20


<210>  13084
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13084
cuguuguacu acauuaaaaa                                                   20


<210>  13085
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13085
ucagcagguu cauugacugu                                                   20


<210>  13086
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13086
augaaccugc ugaugacuuu                                                   20


<210>  13087
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13087
gcaaucaagu gguuaccagc                                                   20


<210>  13088
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13088
uugcagcaac aauauaagca                                                   20


<210>  13089
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13089
accguguaua uuauacgcuu                                                   20


<210>  13090
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13090
ucacuguaaa gcuucaucag                                                   20


<210>  13091
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13091
ccuuauuucc uauggaaaca                                                   20


<210>  13092
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13092
ccagcgauga uaucccagug                                                   20


<210>  13093
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13093
ugucccacac aaucucuugg                                                   20


<210>  13094
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13094
cacacaaucu cuuggugagg                                                   20


<210>  13095
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13095
uacuguuucc ccuacccuau                                                   20


<210>  13096
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13096
ugcaguuuga aaugugaugu                                                   20


<210>  13097
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13097
gaaguuugcc acucgccucu                                                   20


<210>  13098
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13098
guuucucuaa ggguacaguu                                                   20


<210>  13099
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13099
aacacacuga gaagauggaa                                                   20


<210>  13100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13100
cagaauaaca augaagucug                                                   20


<210>  13101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13101
gacagcacag aaacccucac                                                   20


<210>  13102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13102
gacuucauug uuauucugug                                                   20


<210>  13103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13103
uuucauucuc uggcagugag                                                   20


<210>  13104
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13104
ggcugcugug gcauugugug                                                   20


<210>  13105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13105
cagaggcgca gccagcccug                                                   20


<210>  13106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13106
gauuugccaa gucacagagg                                                   20


<210>  13107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13107
ugccuuauuu ucaucucacc                                                   20


<210>  13108
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13108
uauuuccaaa guauagcacc                                                   20


<210>  13109
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13109
agguuuaaga uuuauuuucc                                                   20


<210>  13110
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13110
gucaagguuu aagauuuauu                                                   20


<210>  13111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13111
uguugaggag aaacaaauuc                                                   20


<210>  13112
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13112
uaaaucaugu gaucugcaau                                                   20


<210>  13113
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13113
ccaagcauua aaaagauaau                                                   20


<210>  13114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13114
aauaaugcac ccuguacuuc                                                   20


<210>  13115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13115
agaugagaac ccuaugcaua                                                   20


<210>  13116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13116
cccuauuugu auagaauuuc                                                   20


<210>  13117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13117
guguaaauug acuuaauuac                                                   20


<210>  13118
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13118
auuuacacag accuuuguau                                                   20


<210>  13119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13119
gccacuggcu cuauuuccga                                                   20


<210>  13120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13120
auauguggau ucacauuucu                                                   20


<210>  13121
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13121
cgggagcgug gucuauaugu                                                   20


<210>  13122
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13122
cagcagcuuu cccaguccaa                                                   20


<210>  13123
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13123
aaucuccagg cucuuccaaa                                                   20


<210>  13124
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13124
ugacuccucu caggcugggc                                                   20


<210>  13125
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13125
agacacaaua cuggaugcuc                                                   20


<210>  13126
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13126
cuucucaacu caccaaucau                                                   20


<210>  13127
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13127
gcauagaaaa ccuuuucucu                                                   20


<210>  13128
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13128
ucaucuggca acuuaaugca                                                   20


<210>  13129
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13129
aauauuagau guaauaguua                                                   20


<210>  13130
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13130
gugaaacaac ccagcgacuu                                                   20


<210>  13131
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13131
cuggguuguu ucacugacua                                                   20


<210>  13132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13132
aaagucacaa ugcuacucug                                                   20


<210>  13133
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13133
caaugcuacu cugcacccau                                                   20


<210>  13134
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13134
cuccuggguc ugaaggcuac                                                   20


<210>  13135
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13135
gaaggcuacc ucuguuacca                                                   20


<210>  13136
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13136
uugcuccucc ccaccccagc                                                   20


<210>  13137
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13137
cucuaaagug acaaccuaag                                                   20


<210>  13138
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13138
cuuuagagag acuguccuug                                                   20


<210>  13139
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13139
cuuaugccug uaaucccagc                                                   20


<210>  13140
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13140
cccaggcugg agugcagugg                                                   20


<210>  13141
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13141
ugcuugaucu agcaccugcg                                                   20


<210>  13142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13142
ucagccccuc ucugccuaca                                                   20


<210>  13143
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13143
cucuccucca ccugucauca                                                   20


<210>  13144
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13144
gggaugacau gggggugcug                                                   20


<210>  13145
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13145
ucccggacag cucccuuuga                                                   20


<210>  13146
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13146
guguuccuua ucucacacac                                                   20


<210>  13147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13147
gaggucuuua agguaugcca                                                   20


<210>  13148
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13148
uuaagguaug ccaaguggag                                                   20


<210>  13149
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13149
agaacaagag agcuggaugu                                                   20


<210>  13150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13150
cuaaccugua uccuccugcc                                                   20


<210>  13151
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13151
agaagaggca guacuaggaa                                                   20


<210>  13152
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13152
ccuuccuagu acugccucuu                                                   20


<210>  13153
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13153
ggaaagcccu ggaauagugu                                                   20


<210>  13154
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13154
gcuaagauga ggccugaaag                                                   20


<210>  13155
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13155
ccccaacugc ugaguuggag                                                   20


<210>  13156
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13156
aaguuuggcu gcaaagaaga                                                   20


<210>  13157
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13157
aagccucucu ucucccuguu                                                   20


<210>  13158
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13158
aagccucucu ucugcccugu                                                   20


<210>  13159
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13159
cagcacacug guuucucuuc                                                   20


<210>  13160
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13160
cugggaaggg ucuggcaggg                                                   20


<210>  13161
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13161
ggcagggugg agcguucugg                                                   20


<210>  13162
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13162
acccaaagcc ccuagcgcuc                                                   20


<210>  13163
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13163
caggagagga gacaagaaca                                                   20


<210>  13164
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13164
ccucuccugu gacaguggga                                                   20


<210>  13165
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13165
caggagagcu ccugcggcca                                                   20


<210>  13166
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13166
cuccacacau uaccucauca                                                   20


<210>  13167
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13167
caucacugug cugggcugca                                                   20


<210>  13168
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13168
cccugauuuu acagaaaggu                                                   20


<210>  13169
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13169
uuuuuuuuua aguguuaucu                                                   20


<210>  13170
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13170
cuucacagua cuugguacag                                                   20


<210>  13171
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13171
ccucuguggu cccuucacag                                                   20


<210>  13172
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13172
guaacuuucc uuaacagcag                                                   20


<210>  13173
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13173
uuccaauagu cuguaacuuu                                                   20


<210>  13174
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13174
guuaaucauu acgucuuucc                                                   20


<210>  13175
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13175
aaauuuucuu ggacuccccu                                                   20


<210>  13176
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13176
aagaaaauuu ugacauguau                                                   20


<210>  13177
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13177
acauuuccag gaaggcuggu                                                   20


<210>  13178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13178
cucguuugcu cucaccagcc                                                   20


<210>  13179
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13179
cgaugaagcc agggcacagg                                                   20


<210>  13180
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13180
aaagaguuac cagcgcugcc                                                   20


<210>  13181
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13181
uugugugcaa agggcagccu                                                   20


<210>  13182
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13182
gcauguccuu gugugcaaag                                                   20


<210>  13183
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13183
ccguucucau uggcaggacu                                                   20


<210>  13184
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13184
ugccaaugag aacggagaca                                                   20


<210>  13185
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13185
gagaguaguc cugccaauga                                                   20


<210>  13186
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13186
ugcagaagau ucaaacacaa                                                   20


<210>  13187
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13187
uguguuugaa ucuucugcag                                                   20


<210>  13188
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13188
ucuuguguuu gaaucuucug                                                   20


<210>  13189
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13189
ucccuggcgg uugcugcugc                                                   20


<210>  13190
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13190
gaugaaaggu agucuucccu                                                   20


<210>  13191
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13191
cacugaaggu cagaugaaag                                                   20


<210>  13192
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13192
ccagaacccc cucaaccccu                                                   20


<210>  13193
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13193
cuuuuuguga ccagacugcc                                                   20


<210>  13194
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13194
caaaaaggga cagggguuga                                                   20


<210>  13195
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13195
ggucacaaaa agggacaggg                                                   20


<210>  13196
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13196
uacagguugg gcagucuggu                                                   20


<210>  13197
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13197
agaaggaaag ucauacaggu                                                   20


<210>  13198
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13198
aaaucacuua uggaggauuu                                                   20


<210>  13199
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13199
cuuguuuuug cguggucuaa                                                   20


<210>  13200
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13200
cuaaugaaac aucaacugga                                                   20


<210>  13201
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13201
aguaauguuc ugacaucuga                                                   20


<210>  13202
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13202
gaacauuacu ggacaccaca                                                   20


<210>  13203
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13203
aaaaugccau cagaggugac                                                   20


<210>  13204
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13204
ccucugaugg cauuuuugac                                                   20


<210>  13205
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13205
uaaaagcauc ccaaguaggg                                                   20


<210>  13206
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13206
acccagaccu uccaucacau                                                   20


<210>  13207
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13207
ggguagacuu guacccuacu                                                   20


<210>  13208
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13208
ugaaucgcuu uaugugaugg                                                   20


<210>  13209
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13209
aguauugcuu cuuauaucau                                                   20


<210>  13210
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13210
uaacuucaua ggggaaaagg                                                   20


<210>  13211
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13211
uaauacauau gucuuaacuu                                                   20


<210>  13212
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13212
gucuccauau ucaguucuag                                                   20


<210>  13213
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13213
ccauauucag uucuagagau                                                   20


<210>  13214
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13214
ggaaaaaucu cuagaacuga                                                   20


<210>  13215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13215
ugcagcuaag gaguacuuca                                                   20


<210>  13216
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13216
ucaggugucc ugcagcuaag                                                   20


<210>  13217
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13217
uuauauuugu gauucuacuu                                                   20


<210>  13218
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13218
aauucaugga gacagaaauu                                                   20


<210>  13219
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13219
ccaugaauuu gacuacucua                                                   20


<210>  13220
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13220
gucuucaaua gguccagagu                                                   20


<210>  13221
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13221
ucaauagguc cagaguuuca                                                   20


<210>  13222
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13222
agaguuucag uuucagaaga                                                   20


<210>  13223
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13223
cugaacuaua cacuuaaaaa                                                   20


<210>  13224
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13224
aucagccugu guucaaguuu                                                   20


<210>  13225
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13225
uagagugaaa acuugaacac                                                   20


<210>  13226
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13226
cuuaaacuac ccaugauaua                                                   20


<210>  13227
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13227
uauaucaugg guaguuuaag                                                   20


<210>  13228
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13228
agaaccuugc cuguauuauc                                                   20


<210>  13229
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13229
ccuguagcuc cugagcacuu                                                   20


<210>  13230
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13230
cuaaccucag aauagccuuu                                                   20


<210>  13231
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13231
gaaaggcagg aaucagggca                                                   20


<210>  13232
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13232
cucuuuuaau acuuccccuc                                                   20


<210>  13233
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13233
gggccugcuu gcuuggaagg                                                   20


<210>  13234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13234
gauucuccag guaucaaaac                                                   20


<210>  13235
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13235
cauaugagca gaaggggaac                                                   20


<210>  13236
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13236
cucuugcuca aaaguaagua                                                   20


<210>  13237
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13237
aauuucuugu cacucuugcu                                                   20


<210>  13238
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13238
cugcuaccag ugugucaaau                                                   20


<210>  13239
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13239
acaugauuac uguggugcau                                                   20


<210>  13240
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13240
uuuucucuuc ccucagcuuu                                                   20


<210>  13241
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13241
uuuauuguua aaauguccuu                                                   20


<210>  13242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13242
cuuggagcca uuuucaguug                                                   20


<210>  13243
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13243
auuuuuagaa caagagagcu                                                   20


<210>  13244
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13244
ggcaccacca ugcuuuuagu                                                   20


<210>  13245
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13245
aacuugcagc accauguaug                                                   20


<210>  13246
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13246
cuaggugaau aaucaggcag                                                   20


<210>  13247
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13247
guucagcaau uaucaccugc                                                   20


<210>  13248
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13248
ggaguuugag accagccuga                                                   20


<210>  13249
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13249
caaacuccug accucaagug                                                   20


<210>  13250
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13250
gucucuacaa aaaaauacaa                                                   20


<210>  13251
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13251
cuacaaaaaa auacaaaaau                                                   20


<210>  13252
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13252
agagugcagu ggcaugaucu                                                   20


<210>  13253
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13253
uccagucuag agugcagugg                                                   20


<210>  13254
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13254
cacuuugucu uccagucuag                                                   20


<210>  13255
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13255
caaaaauaaa uaaauaaaua                                                   20


<210>  13256
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13256
ugcucuugag gaguuuauag                                                   20


<210>  13257
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13257
ggaacuuaaa aacuauaaac                                                   20


<210>  13258
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13258
gagccacaca caggccgucu                                                   20


<210>  13259
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13259
acucuuaagu uguuugggca                                                   20


<210>  13260
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13260
uuuuaccuau aguaagcgua                                                   20


<210>  13261
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13261
ggcucaugaa augugaaugu                                                   20


<210>  13262
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13262
cagguuuugg uuuuucucuc                                                   20


<210>  13263
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13263
ggaaggugua gcuugggauu                                                   20


<210>  13264
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13264
gaaaaauuaa aacccaggga                                                   20


<210>  13265
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13265
gggccacugg gcucccucau                                                   20


<210>  13266
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13266
ggucagggcc acugggcucc                                                   20


<210>  13267
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13267
cuguagaucc caccgagagu                                                   20


<210>  13268
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13268
auaguaaaua uguggauaau                                                   20


<210>  13269
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13269
uaugcacaaa ugucuauagu                                                   20


<210>  13270
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13270
caaacacaaa uuugacucgc                                                   20


<210>  13271
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13271
aauuuguguu ugagacagaa                                                   20


<210>  13272
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13272
uagccacggg ugcuuucuuu                                                   20


<210>  13273
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13273
aacacuaaau uaaucucuug                                                   20


<210>  13274
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13274
uguauuggug gugguggugu                                                   20


<210>  13275
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13275
cugugcccaa cuaauuucuu                                                   20


<210>  13276
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13276
cagcuauaca ggaggcugag                                                   20


<210>  13277
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13277
uaggcacaaa ugauccuuuu                                                   20


<210>  13278
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13278
uagcucacug uagccucaaa                                                   20


<210>  13279
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13279
cccucuguug cccaggcugg                                                   20


<210>  13280
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13280
ugaaaaaaag aaaacaaaac                                                   20


<210>  13281
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13281
auucauuucc uaucuaugug                                                   20


<210>  13282
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13282
ucauaaccca cagagaacua                                                   20


<210>  13283
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13283
uaucccuaag gagcaauaau                                                   20


<210>  13284
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13284
guaaaagcac uaggaccaaa                                                   20


<210>  13285
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13285
uagugcuuuu acagacuuug                                                   20


<210>  13286
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13286
uuucuuacuc aaaacucuuu                                                   20


<210>  13287
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13287
ccaaauucca augauucucu                                                   20


<210>  13288
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13288
gucccuugcc ccaccacagg                                                   20


<210>  13289
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13289
cuugccccac cacaggccuu                                                   20


<210>  13290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13290
gggaauauuc ugagugugaa                                                   20


<210>  13291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13291
ucuaguuccc aaucuugcau                                                   20


<210>  13292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13292
auagugucua agauuugaua                                                   20


<210>  13293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13293
aagauuugau aaacuauaaa                                                   20


<210>  13294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13294
cccucagagg uacauuucug                                                   20


<210>  13295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13295
ccugcacuac aguuguuugu                                                   20


<210>  13296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13296
ugcucccuca cucaacugug                                                   20


<210>  13297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13297
aaugcauuug guuuagaggc                                                   20


<210>  13298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13298
ugugucuaau gcauuugguu                                                   20


<210>  13299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13299
gucauguguc uaaugcauuu                                                   20


<210>  13300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13300
caauaaaugc agaccaaaug                                                   20


<210>  13301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13301
gcauuuauug agaccaaauc                                                   20


<210>  13302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13302
uuuuauuauu ucuccauuca                                                   20


<210>  13303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13303
acaaguguuu auaaauaaaa                                                   20


<210>  13304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13304
gaacaguuau gacuuaccaa                                                   20


<210>  13305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13305
uaacuguucu gacucacuuu                                                   20


<210>  13306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13306
gccagaaggu gauagagcua                                                   20


<210>  13307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13307
agggucggcc agaaggugau                                                   20


<210>  13308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13308
auacugcuuu cuaggccuua                                                   20


<210>  13309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13309
gggaacugaa auaaacaacc                                                   20


<210>  13310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13310
cuaaacagau ccgauuuuau                                                   20


<210>  13311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13311
auauccuagu uuguuuucca                                                   20


<210>  13312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13312
gcuuauaaaa uagaaaaaug                                                   20


<210>  13313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13313
uuucccacuu uuauacauau                                                   20


<210>  13314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13314
gucauagagg aagaaacugc                                                   20


<210>  13315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13315
uagaggaaga aacugcccaa                                                   20


<210>  13316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13316
uauaauuagu aaauagcaaa                                                   20


<210>  13317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13317
guagagaaaa ggcugagggc                                                   20


<210>  13318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13318
uuaggcucuu auuauaauau                                                   20


<210>  13319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13319
cugggguagc gugagcaagg                                                   20


<210>  13320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13320
uccuugcuca cgcuacccca                                                   20


<210>  13321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13321
ucaccaguca uccuugcuca                                                   20


<210>  13322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13322
acugugguca ucaccaguca                                                   20


<210>  13323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13323
cauuucuuau uuauuuauuu                                                   20


<210>  13324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13324
cacuuaaagg cuaucuggcu                                                   20


<210>  13325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13325
uaccuuaaug aaaugcagca                                                   20


<210>  13326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13326
gcucccgcaa agcaaacauu                                                   20


<210>  13327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13327
ucccaccagg uaauguuugc                                                   20


<210>  13328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13328
gcuauucuca ugucacaguu                                                   20


<210>  13329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13329
caguuaacac uccaucuguu                                                   20


<210>  13330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13330
auagauagac uucagggugu                                                   20


<210>  13331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13331
aucuauagac uucuaacagu                                                   20


<210>  13332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13332
aagccugucu gaaauuuuac                                                   20


<210>  13333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13333
gaaauuuuac acaauuuugu                                                   20


<210>  13334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13334
uuuccaucag uuuuucaaag                                                   20


<210>  13335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13335
uucuucccua ccugauuuac                                                   20


<210>  13336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13336
acagcugggg gcggcucugc                                                   20


<210>  13337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13337
uggaauacua caacucugaa                                                   20


<210>  13338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13338
agcccagcca gcuacccauc                                                   20


<210>  13339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13339
ggaccuuggc ugaacagaag                                                   20


<210>  13340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13340
agaccuccag guccagccca                                                   20


<210>  13341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13341
ucuguucagc caagguccag                                                   20


<210>  13342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13342
aaaagaaaua auuaguggaa                                                   20


<210>  13343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13343
gaagggaaac cuuaccuguu                                                   20


<210>  13344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13344
uugcuuaaau augccaggag                                                   20


<210>  13345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13345
ccuaaagcuc cuggcauauu                                                   20


<210>  13346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13346
caccuggugu uacuccacaa                                                   20


<210>  13347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13347
ugaaggaggc acauuuucuu                                                   20


<210>  13348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13348
aggggggaua ccuagugauu                                                   20


<210>  13349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13349
ucuccacugu aucuucagug                                                   20


<210>  13350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13350
gaacucacaa aauuagguag                                                   20


<210>  13351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13351
uuuuagauga guuggaguuu                                                   20


<210>  13352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13352
gcuuacuaaa cuccaacuca                                                   20


<210>  13353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13353
cuuuagagag ucaauaagca                                                   20


<210>  13354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13354
auaagcauuu cucuaucaga                                                   20


<210>  13355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13355
gaguuugcau ucaugccuug                                                   20


<210>  13356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13356
uacagcuagu uaguggcaua                                                   20


<210>  13357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13357
auggaugcaa aaacuaaggc                                                   20


<210>  13358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13358
cuaucaugac aagacccagg                                                   20


<210>  13359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13359
ugauagugac aacaaccaua                                                   20


<210>  13360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13360
ugucaugaua gugacaacaa                                                   20


<210>  13361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13361
uaacuuaugu guguacuguu                                                   20


<210>  13362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13362
uauaugauua uccagugucc                                                   20


<210>  13363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13363
ucauccaaua cagcaaaacc                                                   20


<210>  13364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13364
cccagaacua auaacacagu                                                   20


<210>  13365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13365
gguucacgaa acuaggagac                                                   20


<210>  13366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13366
ccuaguuucg ugaaccugac                                                   20


<210>  13367
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13367
ucauucauuu gggagaggug                                                   20


<210>  13368
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13368
aaugagaaac aagagacauu                                                   20


<210>  13369
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13369
cuuguuucuc auucgacuac                                                   20


<210>  13370
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13370
agcuuggaga guaauuauau                                                   20


<210>  13371
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13371
caucccaaag gaauguuggu                                                   20


<210>  13372
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13372
auggaguuca gcacaagcac                                                   20


<210>  13373
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13373
ucagggaaga uaaaguggcu                                                   20


<210>  13374
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13374
ucagaaauaa uaugaagagg                                                   20


<210>  13375
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13375
gaaauaauau gaagaggaag                                                   20


<210>  13376
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13376
cuuccucuuc auauuauuuc                                                   20


<210>  13377
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13377
agcacugaga aauaauuaaa                                                   20


<210>  13378
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13378
agguacaaaa aaaucacagg                                                   20


<210>  13379
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13379
cuuuauggau ucacuguagg                                                   20


<210>  13380
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13380
ggcccugccu cuaccacuca                                                   20


<210>  13381
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13381
ucaaaaucac aaaguaggca                                                   20


<210>  13382
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13382
cuagcaauua guuuaaauuc                                                   20


<210>  13383
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13383
guacuuguuu uuuuaacacu                                                   20


<210>  13384
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13384
aaaaucuguc ucccuuagca                                                   20


<210>  13385
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13385
cccuuagcag gaaaggaaaa                                                   20


<210>  13386
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13386
uuuccccugu guguaaacac                                                   20


<210>  13387
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13387
aagccagagu cuuuuccccu                                                   20


<210>  13388
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13388
gaaucccugc uccaccaaug                                                   20


<210>  13389
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13389
caaagcuaau gcauuggugg                                                   20


<210>  13390
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13390
aaggucacaa agcuaaugca                                                   20


<210>  13391
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13391
cuuuauugug guauacuuuu                                                   20


<210>  13392
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13392
uaucaaguac auaauaagua                                                   20


<210>  13393
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13393
aaaaccaacu cuccuguuug                                                   20


<210>  13394
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13394
caaacuccug ggcucaagug                                                   20


<210>  13395
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13395
cagcuaccag ggggcugagg                                                   20


<210>  13396
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13396
aggcugcagu gaccccugau                                                   20


<210>  13397
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13397
cugcagccua gaccuucugg                                                   20


<210>  13398
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13398
cccagauugg agcacagugg                                                   20


<210>  13399
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13399
ccagguuugc ugucacccag                                                   20


<210>  13400
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13400
cacucuguca ccagguuugc                                                   20


<210>  13401
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13401
caaacagaca acaaacaaaa                                                   20


<210>  13402
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13402
guuugagaca aggucucacu                                                   20


<210>  13403
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13403
gaugcugaaa acacagccag                                                   20


<210>  13404
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13404
uggugguggu ucuuuuaagu                                                   20


<210>  13405
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13405
ucuacuuccu cucuggggcu                                                   20


<210>  13406
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13406
gaauccaccu uucccucuua                                                   20


<210>  13407
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13407
uaagagggaa agguggauuc                                                   20


<210>  13408
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13408
cuaguuagua auuuccaugg                                                   20


<210>  13409
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13409
aauaacccau ggaaauuacu                                                   20


<210>  13410
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13410
cuaugguacu acuacuuaga                                                   20


<210>  13411
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13411
aaguaguagu accauagaga                                                   20


<210>  13412
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13412
uuaccugauu guuuugccga                                                   20


<210>  13413
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13413
gcaaaacaau cagguaagga                                                   20


<210>  13414
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13414
caagauauug agaauaacaa                                                   20


<210>  13415
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13415
ggauagaaau auaauuuguu                                                   20


<210>  13416
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13416
auauauuuuu uaagaauauu                                                   20


<210>  13417
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13417
gcauuaaaac uagggguuaa                                                   20


<210>  13418
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13418
aaaaauuuuu uagaguauaa                                                   20


<210>  13419
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13419
cagaaaauug uaaaaacugu                                                   20


<210>  13420
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13420
uuguccaaca gagcaaguag                                                   20


<210>  13421
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13421
aacagagcaa guaguaccuc                                                   20


<210>  13422
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13422
uacguucuuu uucuucaugu                                                   20


<210>  13423
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13423
gucuuacguu cuuuuucuuc                                                   20


<210>  13424
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13424
gauacaaucc agucucagau                                                   20


<210>  13425
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13425
cagauucaga uggacuuaug                                                   20


<210>  13426
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13426
aucugaaucu gagacuggau                                                   20


<210>  13427
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13427
agggcaucaa uucuaccgcu                                                   20


<210>  13428
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13428
cauuuucucc agagccagua                                                   20


<210>  13429
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13429
cuuaaaaaaa gguggggugu                                                   20


<210>  13430
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13430
ucccuaaaca ccccaccuuu                                                   20


<210>  13431
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13431
guguuuuuua uucuuugcau                                                   20


<210>  13432
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13432
ggcuguugcu auccauuugc                                                   20


<210>  13433
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13433
uucugucagg cuguugcuau                                                   20


<210>  13434
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13434
auaucaccgu ugucauucug                                                   20


<210>  13435
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13435
gcgggcucuc aaguaaguuc                                                   20


<210>  13436
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13436
uaaccaaaau gguuucuaaa                                                   20


<210>  13437
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13437
aaaaacaguu ggggugggag                                                   20


<210>  13438
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13438
cuagaaauuc aucugugauc                                                   20


<210>  13439
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13439
uaaaucuaga ucacagauga                                                   20


<210>  13440
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13440
cacccauuau aaauacagua                                                   20


<210>  13441
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13441
auuugccccc cuccccccgu                                                   20


<210>  13442
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13442
gaugcccagc ugauggauuu                                                   20


<210>  13443
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13443
ugccuuuaga ggcugguggg                                                   20


<210>  13444
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13444
ggccguagca uauuacccac                                                   20


<210>  13445
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13445
gcuguuugaa acagcaaucu                                                   20


<210>  13446
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13446
uuacagguac agcaguuacu                                                   20


<210>  13447
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13447
gcguugggau uuucucucua                                                   20


<210>  13448
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13448
cauuuuuaaa acguuauuua                                                   20


<210>  13449
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13449
gucucauuuu uaaaacguua                                                   20


<210>  13450
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13450
aggguuuucu ccagaauggu                                                   20


<210>  13451
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13451
gcaauuuaaa auacuucaga                                                   20


<210>  13452
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13452
gaauucuuua gaucaaucug                                                   20


<210>  13453
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13453
uuuuugcaac uaaaaaauaa                                                   20


<210>  13454
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13454
uuauaaagaa agaaacaaac                                                   20


<210>  13455
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13455
guugcugaau gaaauagauu                                                   20


<210>  13456
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13456
cugaauacuu gccugagaug                                                   20


<210>  13457
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13457
cuccaaaauc aucucaggca                                                   20


<210>  13458
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13458
auuuuaaacu cucuucacug                                                   20


<210>  13459
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13459
cuuccaguga uuuagagcug                                                   20


<210>  13460
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13460
uuuaauuaaa agaaauuugu                                                   20


<210>  13461
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13461
uucagaacua auaaaauauu                                                   20


<210>  13462
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13462
gugguuaguu gaauauuuua                                                   20


<210>  13463
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13463
cuuuuguuug ugaaauuugc                                                   20


<210>  13464
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13464
cuaugccuau ccuggcauag                                                   20


<210>  13465
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13465
ggcauaggau uaacuaauua                                                   20


<210>  13466
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13466
ucgguuuuua ucuucagcac                                                   20


<210>  13467
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13467
augucuguaa aguuucuaag                                                   20


<210>  13468
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13468
guaaaguuuc uaaggcagag                                                   20


<210>  13469
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13469
ccaagcccug ggccauggac                                                   20


<210>  13470
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13470
auggcccagg gcuuggggac                                                   20


<210>  13471
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13471
caggccggua cugguccaug                                                   20


<210>  13472
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13472
uccaugaaac cacucccugu                                                   20


<210>  13473
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13473
agaguaaugc cuuagaacaa                                                   20


<210>  13474
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13474
uuuuagguau uucucuuuug                                                   20


<210>  13475
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13475
caacagauua ucaaaacaua                                                   20


<210>  13476
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13476
guagauaagu uugaaaaagg                                                   20


<210>  13477
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13477
aagagaggga aacaugaaag                                                   20


<210>  13478
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13478
uuucuuaacc uuuuuaaaaa                                                   20


<210>  13479
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13479
ucauuucuuu uaugaaaucc                                                   20


<210>  13480
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13480
aacaacuguu uugagaggau                                                   20


<210>  13481
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13481
ugugauauuu uauuacaaau                                                   20


<210>  13482
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13482
uuguggagau uccuaauuug                                                   20


<210>  13483
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13483
auggauauug gucuuugugg                                                   20


<210>  13484
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13484
uuagcuucau ugaaugcugu                                                   20


<210>  13485
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13485
aaggaagguu uucucucucc                                                   20


<210>  13486
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13486
uucacauggc aguuuaccug                                                   20


<210>  13487
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13487
ggacugagua gacaguucug                                                   20


<210>  13488
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13488
agacuuuaua cacuaauuaa                                                   20


<210>  13489
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13489
acucagucca gacuuuauac                                                   20


<210>  13490
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13490
ugugacacug gcacauacuu                                                   20


<210>  13491
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13491
caggacaagg aucuaaauuc                                                   20


<210>  13492
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13492
uuucuucucg ccuuuuuuaa                                                   20


<210>  13493
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13493
auucuuacca agcugguuaa                                                   20


<210>  13494
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13494
uuguucggcc uauggggccg                                                   20


<210>  13495
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13495
uccccucggc cccauaggcc                                                   20


<210>  13496
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13496
gcuccaucuu caccagaaau                                                   20


<210>  13497
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13497
aguauaaagu ggcuauuuuu                                                   20


<210>  13498
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13498
aucaguucuc ccaacuaauu                                                   20


<210>  13499
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13499
uguaagaaca aaguauugaa                                                   20


<210>  13500
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13500
uauuucucac augaaaaagu                                                   20


<210>  13501
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13501
ggaaaguguu uacuuuuuca                                                   20


<210>  13502
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13502
cuuccaugua auuugcugug                                                   20


<210>  13503
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13503
gcguuguacg gcaggaagcu                                                   20


<210>  13504
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13504
agucagcguu guacggcagg                                                   20


<210>  13505
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13505
gaucagaacu ccccaguauu                                                   20


<210>  13506
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13506
uguuauaaag caaacccaua                                                   20


<210>  13507
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13507
ugacaaucua aaacaaaggg                                                   20


<210>  13508
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13508
agacaagaaa aacuuuuauu                                                   20


<210>  13509
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13509
ggauacuuca guugugggcc                                                   20


<210>  13510
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13510
ucucuaauua gucacaccuc                                                   20


<210>  13511
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13511
caccucuaca uaagugaaaa                                                   20


<210>  13512
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13512
auauucuccu ccaaagcauu                                                   20


<210>  13513
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13513
cgucauuuag gucaaauucu                                                   20


<210>  13514
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13514
uuuaggucaa auucuucuau                                                   20


<210>  13515
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13515
aauucuucua uaacuguguc                                                   20


<210>  13516
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13516
uuaaauuuau accacuuucc                                                   20


<210>  13517
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13517
gaucucuggg uucuagaggg                                                   20


<210>  13518
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13518
uuaaugaagg aauaguagug                                                   20


<210>  13519
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13519
ucguacacag ugggcaggca                                                   20


<210>  13520
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13520
gugucaucgu acacaguggg                                                   20


<210>  13521
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13521
uuuugcuucu acauaguuuc                                                   20


<210>  13522
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13522
gcuuucccag ucaaacccaa                                                   20


<210>  13523
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13523
aacccaaauc ucauuaggug                                                   20


<210>  13524
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13524
ugguaauuca ccuaaugaga                                                   20


<210>  13525
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13525
uuuucacugu uauucucuaa                                                   20


<210>  13526
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13526
aaagaaauuu ccaaacucug                                                   20


<210>  13527
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13527
gaguuuggaa auuucuuugg                                                   20


<210>  13528
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13528
cuccuagauu gagagccaug                                                   20


<210>  13529
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13529
acagaucuau aaguauuuag                                                   20


<210>  13530
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13530
cuuaacaaau gcaaaauuua                                                   20


<210>  13531
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13531
gugauaucuu cacucaccug                                                   20


<210>  13532
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13532
ucacagguga gugaagauau                                                   20


<210>  13533
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13533
uuacagaucu ucugaucaga                                                   20


<210>  13534
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13534
cuccccauuu ucuguuggaa                                                   20


<210>  13535
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13535
uuaaauugca auguguuaau                                                   20


<210>  13536
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13536
uucugguagu aucagcugug                                                   20


<210>  13537
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13537
cauugaucag auggaugaau                                                   20


<210>  13538
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13538
acauccuaau agugaaccug                                                   20


<210>  13539
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13539
uuaaauaaag aacacuuuuu                                                   20


<210>  13540
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13540
ggggaaugau augaacaaau                                                   20


<210>  13541
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13541
uucaauuccu aggaauuugc                                                   20


<210>  13542
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13542
aaagagagac ugcacuuggu                                                   20


<210>  13543
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13543
cucuuuggac auuuaaugga                                                   20


<210>  13544
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13544
gugucaucau ccacugaaag                                                   20


<210>  13545
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13545
ucauccacug aaaguaauga                                                   20


<210>  13546
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13546
uuacuuucag uggaugauga                                                   20


<210>  13547
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13547
aguaauacca gguucucuac                                                   20


<210>  13548
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13548
accaugagca cuuuacaaua                                                   20


<210>  13549
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13549
guaacuuuau ggaauauaau                                                   20


<210>  13550
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13550
aguccaucug uaauacaggc                                                   20


<210>  13551
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13551
aucuguaaua caggcagcuu                                                   20


<210>  13552
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13552
uuacacauuu caggagcuac                                                   20


<210>  13553
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13553
uguuuuagga aaccccaaaa                                                   20


<210>  13554
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13554
uccagcagcu guauaugcaa                                                   20


<210>  13555
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13555
aguucagggu uuguggggcu                                                   20


<210>  13556
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13556
ggauccuuca ugguaaucac                                                   20


<210>  13557
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13557
gauguuaaug aagaguaagu                                                   20


<210>  13558
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13558
uagaaauaau ccugcuguaa                                                   20


<210>  13559
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13559
aaagcauaga uuuaaaaaaa                                                   20


<210>  13560
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13560
agaaaaccua caucaaacuc                                                   20


<210>  13561
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13561
ggcuggugau gcauagaaag                                                   20


<210>  13562
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13562
uugugauguu ggcugauagu                                                   20


<210>  13563
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13563
uuuguuucua gguguaguac                                                   20


<210>  13564
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13564
auuucaacaa ugaauaaucu                                                   20


<210>  13565
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13565
uccuaagaag aucuuaggau                                                   20


<210>  13566
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13566
aaaagccuca uaagcccccu                                                   20


<210>  13567
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13567
ugcuggucua aaagccucau                                                   20


<210>  13568
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13568
ucagugccug gugucgugcu                                                   20


<210>  13569
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13569
uuugcuucuu aucugaacuu                                                   20


<210>  13570
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13570
uuugcaaccc ugaaguucag                                                   20


<210>  13571
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13571
uuucccacca aaaccuucaa                                                   20


<210>  13572
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13572
auuucaauaa ccacugaaau                                                   20


<210>  13573
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13573
acauuacaaa gagaucuuuc                                                   20


<210>  13574
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13574
guguauccua uauuauccac                                                   20


<210>  13575
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13575
uccaucugug agucugugua                                                   20


<210>  13576
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13576
caaaagauuu uguuaacuug                                                   20


<210>  13577
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13577
uguugacuga uggcggcacu                                                   20


<210>  13578
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13578
acaggacuuu cauccaaagu                                                   20


<210>  13579
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13579
uucuccagcu ggcagugccg                                                   20


<210>  13580
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13580
ucuaacaaug guuuaaugag                                                   20


<210>  13581
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13581
agcuuucacu uuagaaacag                                                   20


<210>  13582
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13582
uuggcacuuc uguuucuaaa                                                   20


<210>  13583
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13583
ucugaauaca auuuauaaua                                                   20


<210>  13584
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13584
ucuuuuaagg gugauucuca                                                   20


<210>  13585
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13585
gucuucuuuu aagggugauu                                                   20


<210>  13586
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13586
uuaaacaaca uagagaauuu                                                   20


<210>  13587
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13587
guuauuuuag uggcuaacaa                                                   20


<210>  13588
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13588
auuuuccaug gaacacuugg                                                   20


<210>  13589
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13589
ugaugaggcg uaagugcccu                                                   20


<210>  13590
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13590
gcuucacugg ucucacauuc                                                   20


<210>  13591
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13591
cacauucagc uguacgauua                                                   20


<210>  13592
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13592
ggaguucgag accagccugg                                                   20


<210>  13593
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13593
ggaguacagu ggcgugaucu                                                   20


<210>  13594
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13594
aaaacaggag guggccaggc                                                   20


<210>  13595
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13595
gucaaaaaca ggagguggcc                                                   20


<210>  13596
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13596
aaaagaaauu ucauacaaag                                                   20


<210>  13597
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13597
ugacguucuu uaccaauugc                                                   20


<210>  13598
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13598
agaccaggag gaaaaaaaau                                                   20


<210>  13599
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13599
uucucuccgg uguagucugu                                                   20


<210>  13600
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13600
aaggcucaua uuuuaauuac                                                   20


<210>  13601
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13601
uuaaugaauu gagaacauuu                                                   20


<210>  13602
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13602
uuuacuuacu ugucagauca                                                   20


<210>  13603
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13603
gaucaucuaa uaacuggcau                                                   20


<210>  13604
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13604
aaaaaacaga aagguuucag                                                   20


<210>  13605
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13605
uuuuuuauaa ccauaauucu                                                   20


<210>  13606
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13606
gaggauuaaa agaaaaacau                                                   20


<210>  13607
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13607
aauucagcuu aaaucuugau                                                   20


<210>  13608
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13608
aagaaagaag ucaagauuuu                                                   20


<210>  13609
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13609
agaauggauc aaagaaacca                                                   20


<210>  13610
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13610
uaauauauuu ucuaauuuuc                                                   20


<210>  13611
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13611
cuaucuucuu caguucugcu                                                   20


<210>  13612
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13612
auuguagauc uuuccugcuu                                                   20


<210>  13613
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13613
cagagauucu gguacguugu                                                   20


<210>  13614
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13614
uuguucucau ugguuucaaa                                                   20


<210>  13615
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13615
uucaggagca gguuguucag                                                   20


<210>  13616
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13616
auuaggucug cuugguccag                                                   20


<210>  13617
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13617
gcuuggucca gagcugaguu                                                   20


<210>  13618
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13618
agagcugagu ucaaguccug                                                   20


<210>  13619
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13619
ugggagggug ugugugucug                                                   20


<210>  13620
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13620
aaucccugaa uagaccaaua                                                   20


<210>  13621
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13621
auucagggau ucgacuucuu                                                   20


<210>  13622
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13622
ugggccuuuu uugguuggua                                                   20


<210>  13623
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13623
cucuuuuucu guugcuugga                                                   20


<210>  13624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13624
uccuaucuga auacccuuua                                                   20


<210>  13625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13625
aacugucucu guuugcagau                                                   20


<210>  13626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13626
cuguuugcag augacaugau                                                   20


<210>  13627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13627
ucugcaaaca gagacaguuu                                                   20


<210>  13628
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13628
caggauacaa aaucaaugug                                                   20


<210>  13629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13629
auuauucgug uauaggaaug                                                   20


<210>  13630
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13630
uccacaugcc uuguaaguug                                                   20


<210>  13631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13631
ucucuuauuu ccuugagcag                                                   20


<210>  13632
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13632
gugguagcuu gauggggaua                                                   20


<210>  13633
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13633
uggcuauaca gguucuguuu                                                   20


<210>  13634
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13634
gguagcauga ugccuccagc                                                   20


<210>  13635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13635
auugaauccu uuucuuguuu                                                   20


<210>  13636
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13636
accuaaaggu uuguugguuu                                                   20


<210>  13637
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13637
agggcuuuuc uuuguuggga                                                   20


<210>  13638
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13638
uuuaguucuu uuucuugccu                                                   20


<210>  13639
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13639
ucuguuaaca gauaauuuua                                                   20


<210>  13640
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13640
gcaguccggc cugggcgaca                                                   20


<210>  13641
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13641
ggccugggcg acagagcgag                                                   20


<210>  13642
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13642
cccaggccgg acugcggacu                                                   20


<210>  13643
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13643
cgcucugucg cccaggccgg                                                   20


<210>  13644
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13644
caaaaaaaaa aaaaaaaaaa                                                   20


<210>  13645
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13645
uuuguuuccu uaaguugguu                                                   20


<210>  13646
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13646
ucuuuaauuu cuuucagcaa                                                   20


<210>  13647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13647
uuuuauuaug ucaucuuuaa                                                   20


<210>  13648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13648
uucaauccuu gaacacaaga                                                   20


<210>  13649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13649
caaaguuuuc ccuguuuucu                                                   20


<210>  13650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13650
uagccaggaa auuauggcca                                                   20


<210>  13651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13651
uguguaugua uuuucucuuu                                                   20


<210>  13652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13652
aucaccaaac ugggaaaaua                                                   20


<210>  13653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13653
aaagucaauc accaaacugg                                                   20


<210>  13654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13654
aucagaggua gguaauaaaa                                                   20


<210>  13655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13655
ccaacuagua uuaugagagg                                                   20


<210>  13656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13656
gucugacuaa gaguguacag                                                   20


<210>  13657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13657
gacuaagagu guacagcuga                                                   20


<210>  13658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13658
gacagacaca ucagcgcauc                                                   20


<210>  13659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13659
uuugcugcug aucauguaau                                                   20


<210>  13660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13660
guccuuugcu gcugaucaug                                                   20


<210>  13661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13661
caacauguug auucaugucu                                                   20


<210>  13662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13662
uguuguuuug ugagcugucu                                                   20


<210>  13663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13663
acccccuugu aaagauuugg                                                   20


<210>  13664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13664
aaguaggaag caauggcagc                                                   20


<210>  13665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13665
cuucuuguua cgugccuaca                                                   20


<210>  13666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13666
uugguggaua cagacuguug                                                   20


<210>  13667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13667
guauccacca aagacucgcu                                                   20


<210>  13668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13668
aacacagauu cccgcaugca                                                   20


<210>  13669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13669
uccugcucaa ucucuauuuu                                                   20


<210>  13670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13670
ugaaaccaau cauuguggca                                                   20


<210>  13671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13671
cccauuuuug ugacucuggc                                                   20


<210>  13672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13672
caaaaauggg agacccucuu                                                   20


<210>  13673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13673
cuuuuuaauc aguaccugaa                                                   20


<210>  13674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13674
guuucgaauu ccagcaggac                                                   20


<210>  13675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13675
ugcuggaauu cgaaacagac                                                   20


<210>  13676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13676
ugcagccgca gcccaugaca                                                   20


<210>  13677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13677
ugggcugcgg cugcaggacg                                                   20


<210>  13678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13678
aaagaaugga acaaguauua                                                   20


<210>  13679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13679
cucuuauuca gaauguccug                                                   20


<210>  13680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13680
ugaauacaca aaucacuuac                                                   20


<210>  13681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13681
ucuauuaggg uugaggaaau                                                   20


<210>  13682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13682
gauaggucuu cuauuagggu                                                   20


<210>  13683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13683
gugucugaua ggucuucuau                                                   20


<210>  13684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13684
guaggaugac uuuucugggg                                                   20


<210>  13685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13685
uccuaccgac aguuguccgu                                                   20


<210>  13686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13686
uuauguggua ccccagaaaa                                                   20


<210>  13687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13687
gcuugucugc cggcugacau                                                   20


<210>  13688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13688
gccggcugac auuucggaau                                                   20


<210>  13689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13689
gccggcagac aagcagacag                                                   20


<210>  13690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13690
ucaucuaaua acgugggcau                                                   20


<210>  13691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13691
gacaaguaaa aaucuuaaaa                                                   20


<210>  13692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13692
gacaaacaau gcccacguua                                                   20


<210>  13693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13693
agcuguuucu uuuuaagauu                                                   20


<210>  13694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13694
auucauacua uuuaaaaaca                                                   20


<210>  13695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13695
uaccaggcaa uacuugacuu                                                   20


<210>  13696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13696
acagcuugca agguauguaa                                                   20


<210>  13697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13697
acuucugaug ggauggaguc                                                   20


<210>  13698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13698
cucugcauga cauuuacaac                                                   20


<210>  13699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13699
ugcagagaga cuccauccca                                                   20


<210>  13700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13700
uuaauauccu gccuuuuuuu                                                   20


<210>  13701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13701
ucaucaauua cuuaguuucu                                                   20


<210>  13702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13702
ucacaguagc cuguaagacc                                                   20


<210>  13703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13703
uacaggcuac ugugaagacu                                                   20


<210>  13704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13704
cgcucccuua ucuccuucag                                                   20


<210>  13705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13705
uugcuagaug ucaccccagc                                                   20


<210>  13706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13706
ccccagcgaa gcuuuuccug                                                   20


<210>  13707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13707
aaauaaagac auugaacauu                                                   20


<210>  13708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13708
ggcacagaga agcuggguag                                                   20


<210>  13709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13709
ugggaaccuc aguugccugg                                                   20


<210>  13710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13710
ucaugcucuc acucacccuu                                                   20


<210>  13711
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13711
guuugaaaua aggugaauuu                                                   20


<210>  13712
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13712
caugucaguu ugaaauaagg                                                   20


<210>  13713
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13713
ucaucagcug uuggcaugag                                                   20


<210>  13714
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13714
uuauuuuuaa aucauaacuu                                                   20


<210>  13715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13715
uaaacuagau guaguucaag                                                   20


<210>  13716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13716
ucaacuaucu aaauuccauu                                                   20


<210>  13717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13717
agcuugucau caacuaucua                                                   20


<210>  13718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13718
aacaaugggu cuagcuuguc                                                   20


<210>  13719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13719
aaaaauaaaa uauaugcagu                                                   20


<210>  13720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13720
auauaaauaa ggacauacuu                                                   20


<210>  13721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13721
uuauuuauau ggacauuuaa                                                   20


<210>  13722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13722
aaaaagaaaa aauauuuagc                                                   20


<210>  13723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13723
uuucacagga augauuaagg                                                   20


<210>  13724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13724
ucacaccuug aagcaguaag                                                   20


<210>  13725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13725
uaggaaguua uauccaggca                                                   20


<210>  13726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13726
gaagaaaaua aagcccugaa                                                   20


<210>  13727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13727
auuuggauuu aucgauucau                                                   20


<210>  13728
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13728
aaaugaaaug gaaagaaauu                                                   20


<210>  13729
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13729
accuucagag ugcucuacaa                                                   20


<210>  13730
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13730
guuucgaucu uuugccccgg                                                   20


<210>  13731
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13731
ucaaagcaac agcaccagcc                                                   20


<210>  13732
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13732
ucaaaaucuc caucccuguc                                                   20


<210>  13733
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13733
gaaucaaguu cucaguccuc                                                   20


<210>  13734
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13734
uucucauucu cuuaaacuua                                                   20


<210>  13735
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13735
uaauauucuu ucccucuuua                                                   20


<210>  13736
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13736
uaucuauaau auuguuuaau                                                   20


<210>  13737
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13737
caacugaauc acaacuagag                                                   20


<210>  13738
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13738
gaucugggac aaguaacuuc                                                   20


<210>  13739
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13739
cagcuacuca ggaggcugag                                                   20


<210>  13740
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13740
aauacguuac auacgagagc                                                   20


<210>  13741
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13741
uuagcucagu ggugccuacu                                                   20


<210>  13742
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13742
uaucugaauc ucuuuuaugc                                                   20


<210>  13743
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13743
gauuucuuau uccuuauaac                                                   20


<210>  13744
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13744
cacauuuauc cugaauuuau                                                   20


<210>  13745
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13745
cacaaagucu uacauuugga                                                   20


<210>  13746
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13746
uacauuugga auuaaagaaa                                                   20


<210>  13747
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13747
agaaagcaag cuaauguaaa                                                   20


<210>  13748
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13748
uacgcagcuu uguacaccug                                                   20


<210>  13749
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13749
aggacgcagc agugaacaaa                                                   20


<210>  13750
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13750
ucgacaccua aaacagugcc                                                   20


<210>  13751
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13751
acuaggcacc ccaauccuaa                                                   20


<210>  13752
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13752
gaacucguuu ccagcuuuuc                                                   20


<210>  13753
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13753
cacugccaga agucuucacu                                                   20


<210>  13754
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13754
ucacuguaag gauuuguuca                                                   20


<210>  13755
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13755
gcugcaaaaa gugguuucuu                                                   20


<210>  13756
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13756
gguggaaaau agccaagcag                                                   20


<210>  13757
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13757
agcggugguu aaguauugua                                                   20


<210>  13758
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13758
uuauucuaca uuuguuuacc                                                   20


<210>  13759
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13759
uauuauuuuc auaaagcagu                                                   20


<210>  13760
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13760
agguagguuu acauuaagaa                                                   20


<210>  13761
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13761
accaaagaua ccuucacugu                                                   20


<210>  13762
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13762
augaaaugag gcaccaugag                                                   20


<210>  13763
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13763
agucagaugg acagcaccac                                                   20


<210>  13764
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13764
gauggacagc accacugaua                                                   20


<210>  13765
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13765
aucugacuug acuuauucgu                                                   20


<210>  13766
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13766
agccuaagca acauacaucu                                                   20


<210>  13767
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13767
gacuuuaucu uauaacuaaa                                                   20


<210>  13768
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13768
gacucacuca uuucauucuu                                                   20


<210>  13769
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13769
gauuucaugu guucacagaa                                                   20


<210>  13770
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13770
ucuaauucuc aggcaguuca                                                   20


<210>  13771
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13771
uacuuacuga uuugcauuug                                                   20


<210>  13772
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13772
augggcaaga acuagaacuu                                                   20


<210>  13773
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13773
gaauuucaag uucuaguucu                                                   20


<210>  13774
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13774
aauuugaacc agaacauugu                                                   20


<210>  13775
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13775
accaaauaug aaaugauucc                                                   20


<210>  13776
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13776
gagaaagcug aguuuauugg                                                   20


<210>  13777
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13777
uuucuuccau ucuucuuuuu                                                   20


<210>  13778
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13778
uucucuacuc uagaauggcu                                                   20


<210>  13779
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13779
uucucagagc acucgccagu                                                   20


<210>  13780
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13780
caaucacauu gcuguuuuuu                                                   20


<210>  13781
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13781
guuuaaaguu uucacacaaa                                                   20


<210>  13782
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13782
cuaaaauauu auucaaauaa                                                   20


<210>  13783
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13783
cuaaucauau gcaagcauaa                                                   20


<210>  13784
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13784
aacucagggc auuaauaggg                                                   20


<210>  13785
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13785
ucuuguuuua guuuuuauuu                                                   20


<210>  13786
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13786
cuauccuucu accuggugga                                                   20


<210>  13787
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13787
uggugaugac cuacacacag                                                   20


<210>  13788
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13788
ucaccaggac cacccgagua                                                   20


<210>  13789
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13789
ccuuauaggu aagugaucag                                                   20


<210>  13790
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13790
cagcaugugu uagagugggg                                                   20


<210>  13791
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13791
uucucuauca ggguuucuca                                                   20


<210>  13792
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13792
agguugagaa acccugauag                                                   20


<210>  13793
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13793
cuagagucca gguugagaaa                                                   20


<210>  13794
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13794
agaaugucac uagaguccag                                                   20


<210>  13795
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13795
cauguaagug uuaacauaua                                                   20


<210>  13796
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13796
uuauaaaaaa aauucaagua                                                   20


<210>  13797
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13797
caauuaggga aauaccguac                                                   20


<210>  13798
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13798
ugcuggaaau aaaagagaua                                                   20


<210>  13799
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13799
auuagaagcc ugcuguguaa                                                   20


<210>  13800
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13800
uuguccauua gaagccugcu                                                   20


<210>  13801
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13801
ugcuguggcc uuuaauaaca                                                   20


<210>  13802
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13802
uugacauuua guuguaauca                                                   20


<210>  13803
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13803
aggacuaauu guaauuucca                                                   20


<210>  13804
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13804
ugaauaauga uuacaacuaa                                                   20


<210>  13805
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13805
ugccaaggau cacagcuuau                                                   20


<210>  13806
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13806
acaccucuuc aguucaauau                                                   20


<210>  13807
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13807
uuucaaucga ugaucacaaa                                                   20


<210>  13808
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13808
guuuugcaaa gugccacgcu                                                   20


<210>  13809
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13809
gaacaaucug acuucuagau                                                   20


<210>  13810
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13810
gauuguucug acauauaauu                                                   20


<210>  13811
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13811
uuuuaaaauu ucuuaguaca                                                   20


<210>  13812
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13812
uaugaaauca cuaugaaugg                                                   20


<210>  13813
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13813
uuuuguaaac cauucaaaac                                                   20


<210>  13814
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13814
uauuccacag auguguuuug                                                   20


<210>  13815
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13815
aaauaccacu caaagcuaaa                                                   20


<210>  13816
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13816
uguaacuggc caggauguuu                                                   20


<210>  13817
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13817
agccacuuaa gccuccaggc                                                   20


<210>  13818
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13818
ucggcuugca gcugcugugg                                                   20


<210>  13819
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13819
ugaauaaugc ucuuggcgaa                                                   20


<210>  13820
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13820
ugcuuuugau agguuuguuu                                                   20


<210>  13821
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13821
gcuccaugaa auuacucgcu                                                   20


<210>  13822
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13822
ucucagcuua auaaucccca                                                   20


<210>  13823
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13823
aucagguuua cuguuacaca                                                   20


<210>  13824
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13824
auauaaagag uaaaauaaua                                                   20


<210>  13825
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13825
ucaacuucuu auucugcaug                                                   20


<210>  13826
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13826
cuucacaucc acuccuguuu                                                   20


<210>  13827
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13827
guuuuuugcu gauguacccc                                                   20


<210>  13828
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13828
uguugacaca aaauaaacug                                                   20


<210>  13829
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13829
acaugacuua gcagccugug                                                   20


<210>  13830
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13830
uauaaucaua gaaagcaaua                                                   20


<210>  13831
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13831
ugaucauauc auugguaucc                                                   20


<210>  13832
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13832
aaauauuaaa gaaaauauuc                                                   20


<210>  13833
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13833
guaauaauaa aaauagaauu                                                   20


<210>  13834
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13834
uauaccaguu ucagaaauaa                                                   20


<210>  13835
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13835
uaguacagau cuaaaaaguc                                                   20


<210>  13836
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13836
uguuuaaacu gaaauucuua                                                   20


<210>  13837
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13837
uuguagagaa acaucucacu                                                   20


<210>  13838
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13838
uagaaucuag gaaauacagu                                                   20


<210>  13839
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13839
auuucagaua uguuaaaaua                                                   20


<210>  13840
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13840
aaagugucaa uuucagauau                                                   20


<210>  13841
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13841
aaagaaacuc accagccacu                                                   20


<210>  13842
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13842
cacacuaaag cauuuuccga                                                   20


<210>  13843
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13843
ggagaagcug gcaugacaga                                                   20


<210>  13844
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13844
ugccagcuuc uccugacuuc                                                   20


<210>  13845
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13845
gucaugccag cuucuccuga                                                   20


<210>  13846
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13846
cucuguccua agcugcaccu                                                   20


<210>  13847
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13847
uaagcugcac cuuauuucaa                                                   20


<210>  13848
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13848
acuacuugug agacuagcua                                                   20


<210>  13849
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13849
cacaaguagu ugaccuuuaa                                                   20


<210>  13850
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13850
agcuagucuc acaaguaguu                                                   20


<210>  13851
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13851
uuuugcaacu uuuauagugu                                                   20


<210>  13852
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13852
caauuuugua auccuuuugg                                                   20


<210>  13853
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13853
auuaugguaa caauauuuuu                                                   20


<210>  13854
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13854
auaaaacuaa aauuuaagaa                                                   20


<210>  13855
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13855
uagauaagau gaaauaaaca                                                   20


<210>  13856
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13856
ccacgucaua gauaagauga                                                   20


<210>  13857
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13857
cagaguggag auuucauaag                                                   20


<210>  13858
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13858
uacuuaugaa aucuccacuc                                                   20


<210>  13859
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13859
aaauuggacu caacauuaga                                                   20


<210>  13860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13860
aauuuagaca ucccaucagg                                                   20


<210>  13861
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  targeting sequence with GTCN PAM

<400>  13861
guugguuuag ccugcaaacc                                                   20


<210>  13862
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sgNA variant

<400>  13862
attatctcat tact                                                         14


<210>  13863
<211>  85
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  13863

Met Ala Ser Ser Met Leu Ser Ser Ala Thr Met Val Ala Ser Pro Ala 
1               5                   10                  15      


Gln Ala Thr Met Val Ala Pro Phe Asn Gly Leu Lys Ser Ser Ala Ala 
            20                  25                  30          


Phe Pro Ala Thr Arg Lys Ala Asn Asn Asp Ile Thr Ser Ile Thr Ser 
        35                  40                  45              


Asn Gly Gly Arg Val Asn Cys Met Gln Val Trp Pro Pro Ile Glu Lys 
    50                  55                  60                  


Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Asp Leu Thr Asp Ser Gly 
65                  70                  75                  80  


Gly Arg Val Asn Cys 
                85  


<210>  13864
<211>  65
<212>  PRT
<213>  Unknown

<220>  
<223>  chloroplast transit peptide

<400>  13864

Met Glu Ser Leu Ala Ala Thr Ser Val Phe Ala Pro Ser Arg Val Ala 
1               5                   10                  15      


Val Pro Ala Ala Arg Ala Leu Val Arg Ala Gly Thr Val Val Pro Thr 
            20                  25                  30          


Arg Arg Thr Ser Ser Thr Ser Gly Thr Ser Gly Val Lys Cys Ser Ala 
        35                  40                  45              


Ala Val Thr Pro Gln Ala Ser Pro Val Ile Ser Arg Ser Ala Ala Ala 
    50                  55                  60                  


Ala 
65  


