                         SEQUENCE LISTING

<110>  Dyne Therapeutics, Inc.
 
<120>  MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR MODULATION OF 
       GENES ASSOCIATED WITH MUSCLE ATROPHY

<130>  D0824.70016WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/959,484
<151>  2020-01-10

<150>  US 62/959,596
<151>  2020-01-10

<160>  476   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Gly Phe Asn Ile Lys Asp Asp Tyr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Ile Asp Pro Glu Asn Gly Asp Thr 
1               5               


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Thr Leu Trp Leu Arg Arg Gly Leu Asp Tyr 
1               5                   10  


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Lys Ser Leu Leu His Ser Asn Gly Tyr Thr Tyr 
1               5                   10      


<210>  5
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Arg Met Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Trp Leu Arg Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Phe Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
1               5                   


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ile Thr Phe Asp Gly Ala Asn 
1               5           


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Thr Arg Ser Ser Tyr Asp Tyr Asp Val Leu Asp Tyr 
1               5                   10          


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gln Asp Ile Ser Asn Phe 
1               5       


<210>  13
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Tyr Thr Ser 
1           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gln Gln Gly His Thr Leu Pro Tyr Thr 
1               5                   


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Phe Asp Gly Ala Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Ser Tyr Asp Tyr Asp Val Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Val Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly His Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Gly Tyr Ser Phe Thr Asp Tyr Cys 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Ile Tyr Pro Gly Ser Gly Asn Thr 
1               5               


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Ala Arg Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr 
1               5                   10              


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Glu Ser Val Asp Gly Tyr Asp Asn Ser Phe 
1               5                   10  


<210>  21
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Arg Ala Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Gln Gln Ser Ser Glu Asp Pro Trp Thr 
1               5                   


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Cys Ile Asn Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Arg Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Gly Tyr 
            20                  25                  30          


Asp Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Ala Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Ile Phe Pro Asn Ser Gly Arg Thr 
1               5               


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Ala Arg Glu Gly Asn Phe Gly Ser Leu Asp Tyr 
1               5                   10      


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ser Asn Leu Asn Tyr 
1               5   


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Asp Thr Ser 
1           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Gln Gln Trp Ser Arg Asn Pro Leu Thr 
1               5                   


<210>  31
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Gln Val His Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Phe Pro Asn Ser Gly Arg Thr Asn Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Phe Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  32
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Asn Ser Asn Leu Asn Tyr Met 
            20                  25                  30          


Asn Trp Tyr His Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Ala Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
            100                 105     


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Gly Phe Ser Leu Asn Thr Tyr Asp Val Gly 
1               5                   10  


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Ile Trp Trp Asn Asp Asp Lys 
1               5           


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Thr Leu Tyr Ser Tyr Asp Gly Gly Phe Ala Tyr 
1               5                   10      


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  37
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Ser Thr Ser 
1           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

His Gln Tyr His Arg Ser Pro Tyr Thr 
1               5                   


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Met Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Tyr 
            20                  25                  30          


Asp Val Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asn Asp Asp Lys Tyr Tyr Asn Ser Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ser Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Thr Leu Tyr Ser Tyr Asp Gly Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  40
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Gly Tyr Ser Phe Thr Gly Tyr Asn 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Ile Asn Pro Tyr Tyr Gly Ser Thr 
1               5               


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Ala Arg Gly Asp Tyr Gly Tyr Asp Glu Gly Thr Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  45
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Trp Ala Ser 
1           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Lys Gln Ser Tyr Asn Leu Pro Phe Thr 
1               5                   


<210>  47
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Glu Ile Gln Met Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Tyr Gly Ser Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Gly Tyr Asp Glu Gly Thr Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  48
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Glu Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Gly Tyr Thr Phe Thr Arg His Trp 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Ile Tyr Pro Gly Ser Gly Arg Thr 
1               5               


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Ala Arg Asp Gly Tyr Leu Tyr Ile Asn Tyr Phe Asp Tyr 
1               5                   10              


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Ser Ser Val Ser Phe 
1               5   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Phe Gln Gly Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  54
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg His 
            20                  25                  30          


Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Thr Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Leu Tyr Ile Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  55
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Ser Tyr Ser Leu Thr Ile Ser Ser Met Ala Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Gly Phe Asn Ile Val Asp Asp Tyr 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Ile Tyr Pro Glu Asn Ala Asp Thr 
1               5               


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Thr Thr Ala Thr Gly Thr Gly Trp Phe Ala Tyr 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  60
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Leu Val Ser 
1           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Trp Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  62
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Val Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Ala Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ala Thr Gly Thr Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  63
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Ala Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Gly Tyr Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Ile Leu Pro Gly Ser Gly Ser Thr 
1               5               


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Ala Arg Arg Gly Ala Tyr Gly Asn Phe His Tyr 
1               5                   10      


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Ser Ser Ile Ser Ser Ser Asn 
1               5           


<210>  68
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Gly Thr Ser 
1           


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Gln Gln Trp Arg Ser Tyr Pro Tyr Thr 
1               5                   


<210>  70
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ala Tyr Gly Asn Phe His Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  71
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Ile Asn Pro Asn Tyr Asp Thr Thr 
1               5               


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Tyr Tyr Trp His Phe Asp Val 
1               5                   10                  15      


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Gln Gln Tyr Tyr Asn Tyr Pro Phe Thr 
1               5                   


<210>  77
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Ala Trp Val Lys Glu Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Thr Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Gly Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Tyr Tyr Trp His Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  78
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Gly Phe Asn Ile Lys Asp Tyr Tyr 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Ile Asp Pro Glu Ser Gly Asp Thr 
1               5               


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Tyr Gly His Asp Tyr Arg Val Asp Cys 
1               5                   


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  83
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Lys Val Ser 
1           


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Ser Gln Ser Thr His Ile Pro Trp Thr 
1               5                   


<210>  85
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Ser Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Gly His Asp Tyr Arg Val Asp Cys Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  86
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Ile Asn Pro Asn Tyr Asp Ser Thr 
1               5               


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88

Gln Gln Tyr Tyr His Tyr Pro Phe Thr 
1               5                   


<210>  89
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Gly Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Tyr Tyr Trp His Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  90
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr His Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

Gly Phe Ser Leu Thr Asn Tyr Gly 
1               5               


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Ile Trp Asn Asp Gly Ser Ala 
1               5           


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93

Ala Arg His Glu Ser Ser Asn Pro Phe Ala Tyr 
1               5                   10      


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94

Gln Ser Ile Gly Thr Ser 
1               5       


<210>  95
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95

Ser Ala Ser 
1           


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96

Gln Gln Asn Asn Arg Trp Pro Tyr Thr 
1               5                   


<210>  97
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Asn Asp Gly Ser Ala Thr Tyr Asn Ser Ala Leu Glu 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Glu Ser Ser Asn Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  98
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Ser Ala Ser Glu Ser Ile Ala Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Arg Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99

Asp Phe Asn Ile Lys Asp Asp Tyr 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100

Ile Asp Pro Ala Asn Gly Asn Thr 
1               5               


<210>  101
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101

Ala Leu Gly Tyr Thr Tyr 
1               5       


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102

Gln Ser Leu Leu His Ser Tyr Gly Lys Thr Tyr 
1               5                   10      


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103

Leu Gln Thr Thr His Phe Pro Gln Thr 
1               5                   


<210>  104
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Asp Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Gly Tyr Thr Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  105
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Tyr Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Thr 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106

Gly Phe Thr Phe Ser Asp Tyr Gly 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107

Ile Asn Ser Gly Ser Ser Thr Ile 
1               5               


<210>  108
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108

Ala Arg Pro Gly Asp Tyr Asp Asn Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  109
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109

Gln Asp Val Ser Val Ala 
1               5       


<210>  110
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110

Trp Ala Tyr 
1           


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111

Gln Gln His Tyr Asn Thr Pro Pro Trp Thr 
1               5                   10  


<210>  112
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Gly Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Asp Tyr Asp Asn Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  113
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113

Asp Ile Val Met Thr Gln Ser His Lys Phe Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Val Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Tyr Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Asn Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114

Ile Asp Pro Glu Asn Ala Asp Thr 
1               5               


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115

Tyr Ala Trp Asp Tyr Ser Met Asp Tyr 
1               5                   


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116

Ser Gln Asn Thr His Val Pro Tyr Thr 
1               5                   


<210>  117
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  117

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Ala Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Pro Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Tyr Ala Trp Asp Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  118
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  119

Gly Phe Thr Phe Thr Asp Tyr Gly 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  120

Ile Tyr Pro Ser Ser Gly Asn Ser 
1               5               


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121

Ala Arg Ser Thr Tyr Tyr Gly Ser Pro Ile Asp Tyr 
1               5                   10          


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122

Gln Asp Val Asp Thr Thr 
1               5       


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123

Gln Gln Tyr Ser Thr Tyr Pro Leu Thr 
1               5                   


<210>  124
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124

Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Ser Ser Gly Asn Ser Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Ser Pro Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  125
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Pro Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Thr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Gln Ile Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126

Gly Phe Ser Leu Thr Ser Tyr Ala 
1               5               


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127

Ile Trp Thr Gly Gly Gly Thr 
1               5           


<210>  128
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128

Ala Arg Ile Tyr Asp Gly Tyr Tyr Arg Tyr Phe Asp Val 
1               5                   10              


<210>  129
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129

Gln Ser Val Ser Asn Asp 
1               5       


<210>  130
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130

Tyr Ala Ser 
1           


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  131

Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   


<210>  132
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Leu Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile Tyr Asp Gly Tyr Tyr Arg Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  133
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133

Arg Ile Val Leu Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134

Asn Val Leu Thr Met Pro Thr Ala Tyr 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135

Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  136
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Leu Thr Met Pro Thr Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  137
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Ile Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139

Ile Thr Ser Gly Gly Ser Tyr Thr 
1               5               


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140

Ala Leu Trp Ser Leu Asp Tyr 
1               5           


<210>  141
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141

Ser Ser Leu Ser Tyr 
1               5   


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142

His Gln Arg Arg Ser Tyr Pro Trp Thr 
1               5                   


<210>  143
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143

Glu Val Gln Leu Met Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Phe Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Trp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  144
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Asn Ser Ser Leu Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Glu Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Arg Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  145
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145

Asp Asp Tyr Met Tyr 
1               5   


<210>  146
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146

Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147

Trp Leu Arg Arg Gly Leu Asp Tyr 
1               5               


<210>  148
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Tyr Thr Tyr Leu Phe 
1               5                   10                  15      


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  150
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150

Gly Phe Asn Ile Lys Asp Asp 
1               5           


<210>  151
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  151

Glu Asn Gly 
1           


<210>  152
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152

Leu Arg Arg Gly Leu Asp 
1               5       


<210>  153
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  153

Ser Lys Ser Leu Leu His Ser Asn Gly Tyr Thr Tyr 
1               5                   10          


<210>  154
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  154

His Leu Glu Tyr Pro Phe 
1               5       


<210>  155
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  155

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  156
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  156

Tyr Ile Thr Phe Asp Gly Ala Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  157

Ser Ser Tyr Asp Tyr Asp Val Leu Asp Tyr 
1               5                   10  


<210>  158
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  158

Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  159

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  160
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  160

Gly Tyr Ser Ile Thr Ser Gly Tyr 
1               5               


<210>  161
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  161

Phe Asp Gly 
1           


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  162

Ser Tyr Asp Tyr Asp Val Leu Asp 
1               5               


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  163

Ser Gln Asp Ile Ser Asn Phe 
1               5           


<210>  164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  164

Gly His Thr Leu Pro Tyr 
1               5       


<210>  165
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  165

Asp Tyr Cys Ile Asn 
1               5   


<210>  166
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  166

Trp Ile Tyr Pro Gly Ser Gly Asn Thr Arg Tyr Ser Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  167

Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr 
1               5                   10      


<210>  168
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  168

Arg Ala Ser Glu Ser Val Asp Gly Tyr Asp Asn Ser Phe Met His 
1               5                   10                  15  


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  169

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  170

Gly Tyr Ser Phe Thr Asp Tyr 
1               5           


<210>  171
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  171

Gly Ser Gly 
1           


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  172

Asp Tyr Tyr Pro Tyr His Gly Met Asp 
1               5                   


<210>  173
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  173

Ser Glu Ser Val Asp Gly Tyr Asp Asn Ser Phe 
1               5                   10      


<210>  174
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  174

Ser Ser Glu Asp Pro Trp 
1               5       


<210>  175
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  175

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  176
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  176

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  177
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  177

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  178
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  178

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Trp Leu Arg Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  179
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  179

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Phe Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  180
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  180

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Phe Asp Gly Ala Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Ser Tyr Asp Tyr Asp Val Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  181
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  181

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Val Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly His Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  182
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  182

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Cys Ile Asn Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Arg Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  183
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  183

Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Gly Tyr 
            20                  25                  30          


Asp Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Ala Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  184
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  184

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            100                 105             


<210>  185
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  185

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Trp Leu Arg Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr 
225 


<210>  186
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  186

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Phe Asp Gly Ala Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Ser Tyr Asp Tyr Asp Val Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr 
225         


<210>  187
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  187

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Cys Ile Asn Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Arg Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  188
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  188

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  189
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  189

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  190
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  190

Ala Arg Phe Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr 
1               5                   10                  15  


<210>  191
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  191

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  192
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  192

Ala Ala Ser 
1           


<210>  193
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  193

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  194
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  194

Ser Tyr Trp Ile Gly 
1               5   


<210>  195
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  195

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly Gln 
        


<210>  196
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  196

Phe Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr 
1               5                   10              


<210>  197
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  197

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  198

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  199

Gly Tyr Ser Phe Thr Ser Tyr 
1               5           


<210>  200
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  200

Gly Asp Ser 
1           


<210>  201
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  201

Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Phe Asp 
1               5                   10      


<210>  202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  202

Ser Gln Ser Ile Ser Ser Tyr 
1               5           


<210>  203
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  203

Ser Tyr Ser Thr Pro Leu 
1               5       


<210>  204
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  204

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  205
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  205

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  206
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  206

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Gly Lys Ser Ser 
            100                 105                 110         


Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Gln Leu Val Gln Ser 
        115                 120                 125             


Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys 
    130                 135                 140                 


Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln 
145                 150                 155                 160 


Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp 
                165                 170                 175     


Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser 
            180                 185                 190         


Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys 
        195                 200                 205             


Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Phe Pro Tyr Asp Ser 
    210                 215                 220                 


Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  207
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  207

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  208
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Gly Lys Ser Ser 
            100                 105                 110         


Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Gln Leu Val Gln Ser 
        115                 120                 125             


Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys 
    130                 135                 140                 


Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln 
145                 150                 155                 160 


Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp 
                165                 170                 175     


Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser 
            180                 185                 190         


Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys 
        195                 200                 205             


Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Phe Pro Tyr Asp Ser 
    210                 215                 220                 


Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Asp Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  209
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  209

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Asp Ile Glu Gly Arg Met Asp Asp Ile 
225                 230                 235                 240 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                245                 250                 255     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
            260                 265                 270         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        275                 280                 285             


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    290                 295                 300                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
305                 310                 315                 320 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
                325                 330                 335     


Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Gly Lys Ser Ser Gly Ser 
            340                 345                 350         


Gly Ser Glu Ser Lys Ala Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
        355                 360                 365             


Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser 
    370                 375                 380                 


Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro 
385                 390                 395                 400 


Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp 
                405                 410                 415     


Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp 
            420                 425                 430         


Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser 
        435                 440                 445             


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Phe Pro Tyr Asp Ser Ser Gly 
    450                 455                 460                 


Tyr Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
465                 470                 475                 480 


Ser 
    


<210>  210
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  210

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  211
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  211

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  212
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  212

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  213
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  213

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro 
225                 230         


<210>  214
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  214

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  215
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  215

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser 
1               5                   10                  


<210>  216
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  216

Ser Tyr Trp Met His 
1               5   


<210>  217
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  217

Glu Ile Asn Pro Thr Asn Gly Arg Thr Asn Tyr Ile Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  218

Gly Thr Arg Ala Tyr His Tyr 
1               5           


<210>  219
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  219

Arg Ala Ser Asp Asn Leu Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  220

Asp Ala Thr Asn Leu Ala Asp 
1               5           


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  221

Gln His Phe Trp Gly Thr Pro Leu Thr 
1               5                   


<210>  222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  222

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  223
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  223

Asn Pro Thr Asn Gly Arg 
1               5       


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  224

Thr Ser Tyr Trp Met His 
1               5       


<210>  225
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  225

Trp Ile Gly Glu Ile Asn Pro Thr Asn Gly Arg Thr Asn 
1               5                   10              


<210>  226
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  226

Ala Arg Gly Thr Arg Ala 
1               5       


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  227

Tyr Ser Asn Leu Ala Trp Tyr 
1               5           


<210>  228
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  228

Leu Leu Val Tyr Asp Ala Thr Asn Leu Ala 
1               5                   10  


<210>  229
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  229

Gln His Phe Trp Gly Thr Pro Leu 
1               5               


<210>  230
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  230

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Asn Gly Arg Thr Asn Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Tyr His Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  231
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  231

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Asp Asn Leu Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  232
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  232

Gln His Phe Ala Gly Thr Pro Leu Thr 
1               5                   


<210>  233
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  233

Gln His Phe Ala Gly Thr Pro Leu 
1               5               


<210>  234
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  234

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Asn Gly Arg Thr Asn Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Tyr His Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  235
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  235

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Asp Asn Leu Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  236
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  236

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Asn Gly Arg Thr Asn Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Tyr His Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  237
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  237

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Asp Asn Leu Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  238
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  238

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Asn Gly Arg Thr Asn Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Tyr His Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  239
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  239

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Asp Asn Leu Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  240
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  240

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Asn Gly Arg Thr Asn Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Tyr His Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro 
225     


<210>  241
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  241

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Thr Asn Gly Arg Thr Asn Tyr Ile Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Tyr His Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro 
225     


<210>  242
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  243
<211>  760
<212>  PRT
<213>  Macaca mulatta

<400>  243

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Gly Val Asp Glu Glu Glu Asn Thr 
        35                  40                  45              


Asp Asn Asn Thr Lys Pro Asn Gly Thr Lys Pro Lys Arg Cys Gly Gly 
    50                  55                  60                  


Asn Ile Cys Tyr Gly Thr Ile Ala Val Ile Ile Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Ala Arg Glu Glu Pro 
            100                 105                 110         


Glu Glu Asp Phe Pro Ala Ala Pro Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Thr Thr Asp Phe Thr Ser Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Leu Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Ile Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Gly 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Asp Ser Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Lys Ala Asp Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Gln Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Lys Met Val Thr Ser 
        355                 360                 365             


Glu Asn Lys Ser Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Thr 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Ser Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asp 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Arg Ser Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Val Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Thr Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Leu Phe Leu Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Val Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Arg Asn Ala Glu Lys Arg Asp Lys Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr Tyr Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Ser Ala Leu Leu Glu Ser Leu Lys Leu Arg Arg 
705                 710                 715                 720 


Gln Asn Asn Ser Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  244
<211>  760
<212>  PRT
<213>  Macaca fascicularis

<400>  244

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Gly Val Asp Glu Glu Glu Asn Thr 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Gly Thr Lys Pro Lys Arg Cys Gly Gly 
    50                  55                  60                  


Asn Ile Cys Tyr Gly Thr Ile Ala Val Ile Ile Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Ala Arg Glu Glu Pro 
            100                 105                 110         


Glu Glu Asp Phe Pro Ala Ala Pro Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Thr Thr Asp Phe Thr Ser Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Leu Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Ile Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Gly 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Asp Ser Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Lys Ala Asp Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Gln Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Lys Met Val Thr Ser 
        355                 360                 365             


Glu Asn Lys Ser Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Thr 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Ser Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asp 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Arg Ser Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Val Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Thr Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Leu Phe Leu Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Val Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Arg Asn Ala Glu Lys Arg Asp Lys Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr Tyr Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Ser Ala Leu Leu Glu Ser Leu Lys Leu Arg Arg 
705                 710                 715                 720 


Gln Asn Asn Ser Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  245
<211>  763
<212>  PRT
<213>  Mus musculus

<400>  245

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Ala Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Met Lys Ala Ser Val Arg Lys Pro Lys Arg Phe Asn Gly 
    50                  55                  60                  


Arg Leu Cys Phe Ala Ala Ile Ala Leu Val Ile Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ser Gly Tyr Leu Gly Tyr Cys Lys Arg Val Glu Gln Lys Glu 
                85                  90                  95      


Glu Cys Val Lys Leu Ala Glu Thr Glu Glu Thr Asp Lys Ser Glu Thr 
            100                 105                 110         


Met Glu Thr Glu Asp Val Pro Thr Ser Ser Arg Leu Tyr Trp Ala Asp 
        115                 120                 125             


Leu Lys Thr Leu Leu Ser Glu Lys Leu Asn Ser Ile Glu Phe Ala Asp 
    130                 135                 140                 


Thr Ile Lys Gln Leu Ser Gln Asn Thr Tyr Thr Pro Arg Glu Ala Gly 
145                 150                 155                 160 


Ser Gln Lys Asp Glu Ser Leu Ala Tyr Tyr Ile Glu Asn Gln Phe His 
                165                 170                 175     


Glu Phe Lys Phe Ser Lys Val Trp Arg Asp Glu His Tyr Val Lys Ile 
            180                 185                 190         


Gln Val Lys Ser Ser Ile Gly Gln Asn Met Val Thr Ile Val Gln Ser 
        195                 200                 205             


Asn Gly Asn Leu Asp Pro Val Glu Ser Pro Glu Gly Tyr Val Ala Phe 
    210                 215                 220                 


Ser Lys Pro Thr Glu Val Ser Gly Lys Leu Val His Ala Asn Phe Gly 
225                 230                 235                 240 


Thr Lys Lys Asp Phe Glu Glu Leu Ser Tyr Ser Val Asn Gly Ser Leu 
                245                 250                 255     


Val Ile Val Arg Ala Gly Glu Ile Thr Phe Ala Glu Lys Val Ala Asn 
            260                 265                 270         


Ala Gln Ser Phe Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Lys Asn 
        275                 280                 285             


Lys Phe Pro Val Val Glu Ala Asp Leu Ala Leu Phe Gly His Ala His 
    290                 295                 300                 


Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His 
305                 310                 315                 320 


Thr Gln Phe Pro Pro Ser Gln Ser Ser Gly Leu Pro Asn Ile Pro Val 
                325                 330                 335     


Gln Thr Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Lys Met Glu 
            340                 345                 350         


Gly Ser Cys Pro Ala Arg Trp Asn Ile Asp Ser Ser Cys Lys Leu Glu 
        355                 360                 365             


Leu Ser Gln Asn Gln Asn Val Lys Leu Ile Val Lys Asn Val Leu Lys 
    370                 375                 380                 


Glu Arg Arg Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Tyr Glu Glu 
385                 390                 395                 400 


Pro Asp Arg Tyr Val Val Val Gly Ala Gln Arg Asp Ala Leu Gly Ala 
                405                 410                 415     


Gly Val Ala Ala Lys Ser Ser Val Gly Thr Gly Leu Leu Leu Lys Leu 
            420                 425                 430         


Ala Gln Val Phe Ser Asp Met Ile Ser Lys Asp Gly Phe Arg Pro Ser 
        435                 440                 445             


Arg Ser Ile Ile Phe Ala Ser Trp Thr Ala Gly Asp Phe Gly Ala Val 
    450                 455                 460                 


Gly Ala Thr Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys 
465                 470                 475                 480 


Ala Phe Thr Tyr Ile Asn Leu Asp Lys Val Val Leu Gly Thr Ser Asn 
                485                 490                 495     


Phe Lys Val Ser Ala Ser Pro Leu Leu Tyr Thr Leu Met Gly Lys Ile 
            500                 505                 510         


Met Gln Asp Val Lys His Pro Val Asp Gly Lys Ser Leu Tyr Arg Asp 
        515                 520                 525             


Ser Asn Trp Ile Ser Lys Val Glu Lys Leu Ser Phe Asp Asn Ala Ala 
    530                 535                 540                 


Tyr Pro Phe Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe 
545                 550                 555                 560 


Cys Glu Asp Ala Asp Tyr Pro Tyr Leu Gly Thr Arg Leu Asp Thr Tyr 
                565                 570                 575     


Glu Ala Leu Thr Gln Lys Val Pro Gln Leu Asn Gln Met Val Arg Thr 
            580                 585                 590         


Ala Ala Glu Val Ala Gly Gln Leu Ile Ile Lys Leu Thr His Asp Val 
        595                 600                 605             


Glu Leu Asn Leu Asp Tyr Glu Met Tyr Asn Ser Lys Leu Leu Ser Phe 
    610                 615                 620                 


Met Lys Asp Leu Asn Gln Phe Lys Thr Asp Ile Arg Asp Met Gly Leu 
625                 630                 635                 640 


Ser Leu Gln Trp Leu Tyr Ser Ala Arg Gly Asp Tyr Phe Arg Ala Thr 
                645                 650                 655     


Ser Arg Leu Thr Thr Asp Phe His Asn Ala Glu Lys Thr Asn Arg Phe 
            660                 665                 670         


Val Met Arg Glu Ile Asn Asp Arg Ile Met Lys Val Glu Tyr His Phe 
        675                 680                 685             


Leu Ser Pro Tyr Val Ser Pro Arg Glu Ser Pro Phe Arg His Ile Phe 
    690                 695                 700                 


Trp Gly Ser Gly Ser His Thr Leu Ser Ala Leu Val Glu Asn Leu Lys 
705                 710                 715                 720 


Leu Arg Gln Lys Asn Ile Thr Ala Phe Asn Glu Thr Leu Phe Arg Asn 
                725                 730                 735     


Gln Leu Ala Leu Ala Thr Trp Thr Ile Gln Gly Val Ala Asn Ala Leu 
            740                 745                 750         


Ser Gly Asp Ile Trp Asn Ile Asp Asn Glu Phe 
        755                 760             


<210>  246
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  246

Asp Ile Glu Gly Arg Met Asp 
1               5           


<210>  247
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  247

Phe Val Lys Ile Gln Val Lys Asp Ser Ala Gln Asn Ser Val Ile Ile 
1               5                   10                  15      


Val Asp Lys Asn Gly Arg Leu Val Tyr Leu Val Glu Asn Pro Gly Gly 
            20                  25                  30          


Tyr Val Ala Tyr Ser Lys Ala Ala Thr Val Thr Gly Lys Leu Val His 
        35                  40                  45              


Ala Asn Phe Gly Thr Lys Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val 
    50                  55                  60                  


Asn Gly Ser Ile Val Ile Val Arg Ala Gly Lys Ile Thr Phe Ala Glu 
65                  70                  75                  80  


Lys Val Ala Asn Ala Glu Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr 
                85                  90                  95      


Met Asp Gln Thr Lys Phe Pro Ile Val Asn Ala Glu Leu Ser Phe Phe 
            100                 105                 110         


Gly His Ala His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro 
        115                 120                 125             


Ser Phe Asn His Thr Gln Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro 
    130                 135                 140                 


Asn Ile Pro Val Gln Thr Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe 
145                 150                 155                 160 


Gly Asn Met Glu Gly Asp Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr 
                165                 170                 175     


Cys Arg Met Val Thr Ser Glu Ser Lys Asn Val Lys Leu Thr Val Ser 
            180                 185                 190         


Asn Val Leu Lys Glu 
        195         


<210>  248
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  248

Ile Asp Pro Glu Thr Gly Asp Thr 
1               5               


<210>  249
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  249

Trp Ile Asp Pro Glu Thr Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  250
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  250

Glu Thr Gly 
1           


<210>  251
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  251

Ala Ser Ser Leu Asn Ile Ala 
1               5           


<210>  252
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  252

Trp Ile Asp Pro Glu Ser Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  253
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  253

Glu Ser Gly 
1           


<210>  254
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  254

Gly Tyr Ser Phe Thr Asp Tyr Tyr 
1               5               


<210>  255
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  255

Asp Tyr Tyr Ile Asn 
1               5   


<210>  256
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  256

Gly Tyr Ser Phe Thr Asp Tyr Asp 
1               5               


<210>  257
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  257

Asp Tyr Asp Ile Asn 
1               5   


<210>  258
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  258

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Thr Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Trp Leu Arg Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  259
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  259

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Ser Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Trp Leu Arg Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  260
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  260

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Arg Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  261
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  261

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Arg Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  262
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  262

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Thr Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Trp Leu Arg Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr 
225 


<210>  263
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  263

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Ser Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Leu Trp Leu Arg Arg Gly Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr 
225 


<210>  264
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  264

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Arg Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  265
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  265

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Arg Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Pro Tyr His Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  266
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  266

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Pro Tyr Asp Ser Ser Gly Tyr Tyr Ser Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr 
225                 230 


<210>  267
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  267

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  268
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  268

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10              


<210>  269
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  269

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  270
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  270

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  271
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  271

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  272
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  272

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
1               5                   10              


<210>  273
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  273

Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  274
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  274

Ser Lys Thr Phe Asn Thr His Pro Gln Ser Thr Pro 
1               5                   10          


<210>  275
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  275

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  276
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  276

Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10              


<210>  277
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  277

Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
1               5                   10                  15      


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  278
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  278

Cys Ser Glu Arg Ser Met Asn Phe Cys 
1               5                   


<210>  279
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  279

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  280
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  280

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  281
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  281

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  282
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  282

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  283
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  283

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  284
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  284

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  285
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  285

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  286
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  286

Cys Pro Lys Thr Arg Arg Val Pro Cys 
1               5                   


<210>  287
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  287

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  288
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  288

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  289
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  289

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  293

Cys Gln Ala Gln Gly Gln Leu Val Cys 
1               5                   


<210>  294
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  294

Trp Leu Ser Glu Ala Gly Pro Val Val Thr Val Arg Ala Leu Arg Gly 
1               5                   10                  15      


Thr Gly Ser Trp 
            20  


<210>  295
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  295

Cys Met Gln His Ser Met Arg Val Cys 
1               5                   


<210>  296
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  296

Asp Asp Thr Arg His Trp Gly 
1               5           


<210>  297
<211>  6744
<212>  DNA
<213>  Homo sapiens

<400>  297
agcactcccg gagcctgcaa cgcttgagat cctctccgcg cccgccaccc cgcagggtgc       60

cccgcgccgt tcccgccgcc ccgccgcccc cgtcgcgggc ccctgcaccc cgagcatccg      120

ccccgggtgg cacgtccccg agcccaccag gccggccccg tctccccatc cgtctagtcc      180

gctcgcggtg ccatgccatt cctcgggcag gactggcggt cccccgggca gaactgggtg      240

aagacggccg acggctggaa gcgcttcctg gatgagaaga gcggcagttt cgtgagcgac      300

ctcagcagtt actgcaacaa ggaggtatac aataaggaga atcttttcaa cagcctgaac      360

tatgatgttg cagccaagaa gagaaagaag gacatgctga atagcaaaac caaaactcag      420

tatttccacc aagaaaaatg gatctatgtt cacaaaggaa gtactaaaga gcgccatgga      480

tattgcaccc tgggggaagc tttcaacaga ctggacttct caactgccat tctggattcc      540

agaagattta actacgtggt ccggctgttg gagctgatag caaagtcaca gctcacatcc      600

ctgagtggca tcgcccaaaa gaacttcatg aatattttgg aaaaagtggt actgaaagtc      660

cttgaagacc agcaaaacat tagactaata agggaactac tccagaccct ctacacatcc      720

ttatgtacac tggtccaaag agtcggcaag tctgtgctgg tcgggaacat taacatgtgg      780

gtgtatcgga tggagacgat tctccactgg cagcagcagc tgaacaacat tcagatcacc      840

aggcctgcct tcaaaggcct caccttcact gacctgcctt tgtgcctaca actgaacatc      900

atgcagaggc tgagcgacgg gcgggacctg gtcagcctgg gccaggctgc ccccgacctg      960

cacgtgctca gcgaagaccg gctgctgtgg aagaaactct gccagtacca cttctccgag     1020

cggcagatcc gcaaacgatt aattctgtca gacaaagggc agctggattg gaagaagatg     1080

tatttcaaac ttgtccgatg ttacccaagg aaagagcagt atggagatac ccttcagctc     1140

tgcaaacact gtcacatcct ttcctggaag ggcactgacc atccgtgcac tgccaataac     1200

ccagagagct gctccgtttc actttcaccc caggacttta tcaacttgtt caagttctga     1260

atcccagcac atgacaacac ttcagaaggg tccccctgct gactggagag ctgggaatat     1320

ggcatttgga cacttcattt gtaaatagtg tacattttaa acattggctc gaaacttcag     1380

agataagtca tggagaggac attggagggg agaaatgcag ttgctgactg ggaatttaag     1440

aatgtgaact tctcactaga attggtatgg aaaagcaaaa tactgtaaat aaactttttt     1500

tctaacaatt tgccagcaag actataaggg caataattct atttcagcgg tgaaaatgga     1560

gtcctcttaa tggtcacaga aactctctta tagttcccta ggaagaaaaa ggcaaaactc     1620

aaatacaaaa taggacgctt tgtttacaat gtgaaaattt gtttagaaaa gaaaaaatga     1680

agaaggaaaa ctatatagga gaaattcctg ggctttgggg tttgatctgg tgtttgtttt     1740

gagaaggcga aggaagcgcc acccatccta aacctgcatg ggcacagagc cttaccctac     1800

agagatacca cacaatggtc tacctctaaa agcgtagagt gccctctctg acaacgcatg     1860

tgatccagta ggcagtgtct gtttttctcg taagtgtttt catcactata aaaagtgatt     1920

taaaatggaa agggatattg gaggcaatcc tctggtttca cacttccttt tcaggcaaac     1980

agggccctcc ttagagttat ctgttcacca gaacaaccca aaagcacatg ttcctttttt     2040

cctgtcatgt tgtagctcat ttgggggaaa agaaggccaa cttaaaacag tcccagggga     2100

ggattgcttg agcccaggag tctgaggttt gcagtgagct atgattgtgc cactgcactc     2160

cagcctgtct ccaaaacaaa acaaaacaaa acaaaagccg tcccagagga agtcctgctg     2220

cagaaaagat gatagaattg gtcacccaat caatagctgt gaagacttcc ttattcctgc     2280

tgaacttcct tccttggata tcttcatgga taagcctgtg tctgtggaca gagtggggcc     2340

caagtgctga ggctcgaaag acaggtttta caatcagcca attaaacatc ttaccagttg     2400

ctgtacccct tgccaagggg atgagctgag gagcttcttt tctttaggtc caacatcaaa     2460

atgagtccat ctgagctagg gctttttgca aaggtgatta aaaatcaagg ctggagttcc     2520

agccaaatag ggaggagagg taccacaagt tcatcttaaa cttgcttccg ggctgggtag     2580

ttaaaacagg aagatcccaa ggggatctta cgaggcaaat atcagcaggt aactgtggaa     2640

gaaaggaaat ctcaggacct aatgagttcg ttgtaaaata ttcctgggaa tagatggggg     2700

atctactccc agttttttac tttttacaga atattgttgc tttcctacaa caatgtacat     2760

atatttgcag ttgtatatgc tttttttttt tccaaataaa cttgtcaccc tgcatgccct     2820

tggcaaataa gtgaagcaga aataggaaca cagtccacat tcaagttgag gaacagtgta     2880

tctttaagag ctgagctttg ggtgacctgg aaagggggaa agatggctaa gcatggagag     2940

aaacgaggca agagacaagc tatgatacaa caccgcttca gcccctgccc tcaatagcac     3000

acaacccaca tatcagcttt ctgaagagaa ggaacctact gtttagtgct cctcactttg     3060

caatgtttgt gctacgccag aatttctcca gtttttttca ttatcatccc cctgagaaaa     3120

aaattacatt gaatttaaat tttccctaat aagagaaatt aaatatgaaa gaataggatt     3180

ttgttgggta agattgagct ttggaaggtc acgaaccatt attctatcta aggtgtgtgt     3240

tttgttttgt ttttttttgt tttttttttg caatccctct ccccctgaac caatttcaca     3300

ttgggaatgc aggacctaga ctgctgaata aaaagctact tcttctataa ttgtcaggtt     3360

ctctccaatt tctcagcttc ctcaaagaca tggggtggag ttgggtgtgc catcactgag     3420

agagctctgg aacttttgac tcttagtgac atttttagat ttaggggttc atggccttcc     3480

acatgttgcc accaactggt gatctctgcc ccttcatgct gatcaagaaa gtagaaactc     3540

ctcgtcgcct tcaggtttgc agtcgcagaa acattgcctg ctgtggactg tcagcacaaa     3600

actgggacac tggtgtcatt tagactgtca gcagtgcaca tgattgtacg atagactcca     3660

ggcaaccatg tgcatctgtg caagatgacc tctgccccaa gagaagggtt acggtctaat     3720

taaatgttta ccaagatggt accagtgggc tctccccgtg tcctttggtg ttattggagc     3780

tggtgtatga cagactcaag gaaatttttt aaggaaaatg aagaagaaat caacctttat     3840

ggttctcttt cattggaaga ggagaataag gaaagaaatg gcaggtagag agggaggggg     3900

aaaggaatag aaatggcatg tctttgatgc tgtggcttgt gtggggacaa tgggaagagc     3960

acagcaggca caacatatct gtgttagtgc cacgtggtat ctgttaagta tggccagagc     4020

ctcacatata agtgaagaga gttaagacaa ttcttgctct ttgaacaata atagtctata     4080

gaatttctat tggcaaacca tcccagacaa cctgacctat caaacaaaag caaataatcc     4140

ctgtctcaga actgctggtc taaaagctag aaggggcatg ataatggaaa ttgctagaaa     4200

agagagaatg ctctactctc tttcctgtgc ctacctaccc ccatcctaaa ccctgtaaaa     4260

cagaatttca aaatagatgt caaatatgaa gtaattcaga cttccaaaga aggaaagagt     4320

tctgcccagg gcagtatgag caaatccaca gggatgttaa gatttggtcc aactcaaagg     4380

tttatgggca gtgagcctag agtctcttga gagtaaaccc ttgcatttgg gacaaggaga     4440

atatgtgaag ttcaggagtg ctcacactag agcaagatcc agaaaaaaaa aaatccaatg     4500

gcattttaaa ctagattgca ttatcactca atgctgttac tttgagcaga caaatcagtt     4560

gaatgggagg gcaaatggca gaaatgaaca aaagctatta ggtgaaagca tccccaatgt     4620

atcagttgtg agatgatttt tgtttaatga tgatcaggtt tacattgaag tggcttggaa     4680

gacgtatttc agagggactg ggtttgtact gcaaaactct gaacactaga gcaggttcta     4740

ctagcacttg ggcagtaagg tagcgggtgt gtattatgct attgccatag ttctcgtctt     4800

tgtggattca catacccttt cccatgagga gcttgctact aacagcctcc tgtttctgtt     4860

gtttttatat gggagaagag aaagagcttg gaatttcaat tgtctaaaca attggtatga     4920

tttacaagaa ggcaaaccat tcaggagatg ttcaacagtg tatcattctt agcattcaat     4980

acaatgttta ttataaaata tacacctgag tttatgtttt tctgccaggc tgaagggcaa     5040

taatgtcttg ctatgcaaac actctatttt atgtgtgaat ttttttaact gtaattttat     5100

gtgtgaattt ttttaactaa actctatcat cattttctat gttgacatct tttttttttt     5160

tttaatctgt ttccaactct gagtctgtga actatctctt ctgactggat gctggcctaa     5220

aatcctatta gtgcttaaac agacctcaaa acactctgaa cctgtaggcc aatacagaga     5280

tgttgttctt tgatatatct tgggtccttg atggcttcaa caaacaaggt cataatttgt     5340

ttaaattcag tgttttctgt agataccttc ttctcagttt cattaagaag agtaaccatc     5400

tttggttttc caaagaatgg aaactcctac cctagacttt agacttagag cgtctgcctt     5460

tcacgatgag taagagatcc agaatgttta ggggatgtgc gtcagcccac ctggtacagt     5520

ggcaaagctg aatgcgaact tgaggcctcc tgaggcctga ccttctatgc ccccagccct     5580

ccaccccaag caccttttgg tgtggctgga aacacatgac attggatgtg atttttctca     5640

agcccttcac tgtggaaggc atgggagact gcccagcatt gggcatgtgg ctgttaacgt     5700

ttccatttca agtccctgat tcttactgga gaagttaagg agccacttaa tgttttcaca     5760

gacctctgat tctgttgtga atgtggcatt ccagtgagta caacctgctt gctataaaga     5820

aagcagcata ttttgacaat tttatttctt ccttgggtac ttacattttt attacaaaaa     5880

tggccgttat aaaaaaagac agaagggctg ggcagtggct tgctccctag aaactgagat     5940

tccgaagcag gtgtttcctc tcccctagac tcagaggtac atttaatcca tcttctccat     6000

ttcctccttc aggaccagct atgagattca gtgcatttct agcccagcgg atgttcattc     6060

tccactaaac ttcatctttt actaagcaaa gggggattat tccatgaggc agccaggagc     6120

aaggggccat gatattcatg actttgtctg ctgggcattt ttcaaagtgt ccttgaattc     6180

actcagcaaa caaagctttc tggagaatct ctcaaaactt aggccctgct ccatttggcc     6240

aaaaatgatg gctgctccaa aactctgaac ttcttaaaac tccatctgct acattatttc     6300

tggagtttaa acatgacttt ttctgtcttt gagtatagat gtgtttgttt aattaacgaa     6360

gcacaagtct gttaagcaga aggctccaag ctgtattcta tacttgggaa tccttggtgc     6420

catctttatt ctaccaagtg ccaatcacca tggctaaagt gggcgtatat tacagcctgt     6480

gtcctaagct tagaagcttt aatgtacttt tttaaatgaa aagtattaga gggggttgaa     6540

cattgtaact aaagcataaa gttagaccaa ttacatgcag agatgtttat ttaatattgt     6600

gtgagctgag tccttctgta taaattattt gcacactttt cttgcatgat gaactgattt     6660

tttatagttg tttgtaccag acggtggcat atttttgtaa aaaacttttg acactgaatt     6720

gcaataaatg tttttccaac aaca                                            6744


<210>  298
<211>  6936
<212>  DNA
<213>  Mus musculus

<400>  298
gacggggcag cggcccggga taaatactgc gctcgggcag ccgctcagca ttcccagagt       60

caggaggcga ccttccccaa cgcctgcgcc cctgtgagtg caaggatccc cgcgcccacc      120

caggatccgc agccctccac actagttgac ccactcttgt cccggtcgcc gcctgcgtcg      180

ttccccagca tcttcccaac gcgccgcata ccctgggcaa gccaggccgg ttcctggctg      240

tcaatccgtc ccgtccgtcg gtcgcgtccg cgctctgtac catgccgttc cttgggcagg      300

actggcggtc cccgggccag agctgggtga agacggcgga cggctggaag cgcttcttgg      360

atgagaaaag cggcagcttc gtgagcgacc tcagcagtta ctgcaacaag gaggtataca      420

gtaaggagaa tctgttcagc agcctgaact acgacgtcgc agccaagaag agaaagaaag      480

acattcagaa cagcaaaacc aaaactcagt acttccatca agaaaagtgg atctatgttc      540

acaaaggaag tacgaaggag cgccatggat actgtacttt gggggaagct ttcaacagac      600

tggacttctc gactgccatc ctggattcca gaagattcaa ctacgtagta aggctgttgg      660

agctgatagc aaagtcacag ctcacatccc tgagtggcat cgcccaaaag aacttcatga      720

acattttgga aaaagtggta ctgaaagttc ttgaagacca gcaaaacata agacttatac      780

gggaacttct ccagactctc tacacatcct tatgcacact ggtgcagaga gtcggcaagt      840

ctgtgctggt gggcaacatt aacatgtggg tgtatcggat ggagaccatt ctacactggc      900

agcagcagct gaatagcatc cagatcagca ggcctgcctt caaaggcctc acgatcaccg      960

acctgcctgt gtgcttacaa ctgaacatca tgcagaggct gagtgacggg cgggacctgg     1020

tcagcctggg ccaggcagcc ccagacctgc atgtgctcag tgaggaccgg ctactgtgga     1080

agagactctg ccagtaccac ttctcagaga ggcagattcg caagcgtttg atcttgtctg     1140

acaaagggca gctggattgg aagaagatgt attttaagct tgtacgatgt tacccaagaa     1200

gagagcagta tggggtcacc ctgcagcttt gcaaacactg ccacattctc tcctggaagg     1260

gcactgacca tccgtgcacg gccaacaacc cagagagctg ctccgtctca ctttcccctc     1320

aagactttat caatttgttc aagttctgaa taatcccagc acacgacaac acttcagaag     1380

gcttctaatt ggatggctgg gagtcgggac acttcatttg taaatagtgt acattttaag     1440

cattggcttg aaactgcggg ggatacgtca ttgaggagac gttggcgggg aagagatgca     1500

gttgccgatg gaaatttaca aatgtgaatt ccacatgaga actggtacag aaaagcagaa     1560

atactgtaaa tagacttttt attttcccta acgatttgca agcaagacta taaaggcaag     1620

aactctatgt cagccatgga aacggagtcc tcttgagttc cctaggaaga aaaaggcaaa     1680

aagctcaaaa acaagatgga acactctgtt tacaatgtga aaatgttgtt aagacaaaaa     1740

taaggaagaa ggaagatgaa cgctgtcatt gagaaaccct tgggctttgg gtttggattc     1800

ggggtttgtt ttcagcaggc caagaagtat atccacctga aatctgcacg ggcttaagtc     1860

cttatcctat gaagatgcca cacaatggtc tacctctaaa agcatagcgt gttctctggc     1920

aacatacttt atctgggagg caatgtctgt gtttcatgta agttctatac tctgtgaagt     1980

gatctaagat gggaaggctg ttaggaaaaa aaaaaaaagc cctctcttgg ttctgacttc     2040

ctgtcccccc agtccctctc agtccctgca cctcttctcc tttcatgttg tcactcctgt     2100

agggaaccgg gaggccagct aaagaacagc agaagtcatg aagagagaat taggcacctg     2160

tgcatgctca gaactttcca tttaactctt ccttcttcta gcctgacttc taggcttgtc     2220

cgggcttcct tgagtgtctt catggataag tggatgtctg ggaccttagg agagcccaag     2280

aactgaggct tgagagacac agtttctcac actagccagt taaacattct gccagctgct     2340

gtttcccctc ggcaggccaa tgagctgagg cactgtctgt tctgtaggcc cagcatccaa     2400

ctcaagtcac cctgaaccgg gactttttca caagcatgat ttcaaagaaa gcctgataga     2460

tgtgttcgtc ttaaacttgt ttcaggactg agttagagca aagataaaga gtcccggggg     2520

ttcttgtgag acagagacat gaacactgtg gaagaaagga gaaggagatc tcagggctta     2580

aggagttaat tcctggggtg ggggaaatgt ttttatattt tactttttac agattgttgc     2640

ttttctacaa tgtacatata tttgcaattg tatttgctgt ttttttttta aatctccaaa     2700

taaaattgcc actatgcatg ctcttggcaa acaagcagaa ataggaattt gttccatgta     2760

aatgttaagg tgtggtgtga cctgaagcat tgatgcgtgg ggtagtccta ggaggagagg     2820

aaagatggct gagcgtgaac aagaacaagg ccggggcagt gaacacttct tccttcagtc     2880

gtagagcacc ctcgggttgg tactgtacag gcggatggag tctgtggggc tccctgattt     2940

gcagggtctt acatctgtgc ttacaccaga agttctccat gttttcttta tcagcaccat     3000

ctcctggtgg ccaaattaag ttgaatttaa aggttcgtaa tgagaaaagg gatgtgtaaa     3060

agaacaagat ttcttttaca tggaaaagtt aaaagtctaa agctgaacct tggagattac     3120

aaacattgta acagagaaga gtttcctgtt tgctttggga tttttgaaat cttctcccca     3180

gaaacaattt tacattaaga atgtagggcc ttggggctgg agaggtggct cagcagttaa     3240

gagcactgac tgctcttctg aaggtcctga gttcaattcc tagcaaccac atggtggctc     3300

ataaccatcc ataatgagat ctgatggcct cttctggtga gtctgaagac agctacagtg     3360

tacttacata taataaataa ataaataaat aaataaataa ataaataaat aaataaataa     3420

atctatcttt aaaagaaaaa gaatgtagga cctaggtgga aggaaggaag gaaggaagga     3480

aggaagcaag gaaggaagga aagcaggcag gcctgccgcc acagtgattc tgagtgacag     3540

tgttgaggtt aggggatcgt ggcctttcac atgtcctcag cctgctctgt ggtgcttttc     3600

agagatggga acttgtaggg accttggggt ttacaggtcc gtcaactttg ccagctttga     3660

actgccagcg caaaactagt tagccagtct tacagatagg cagcagtacc caaagtcata     3720

tagcatccat acaccccagg caacaatgta aaatggccct taccccaagc agcaagggca     3780

cagcttcttg aaatatttag taggtgcttg caggttctcc atgacccttg gtgtcattgg     3840

atatggtatg tgacacaacc gaagaatcgt ttgacggatg aagaagagga aaggagcatg     3900

tattggtcgc tgtcactggc tggtagaaaa caggaaggat gtggaaggtg gagagggagt     3960

gggagaggtg tagaaatgat gtatctttga tgctgtttag ggtgggagca acagagagag     4020

gagggcaagc aagataccca tattaggtca tggccagagc ctcatattca agtactggga     4080

gttaaaaaga aaagctctta ggacattaat agtctataga attcttggca aacccatgca     4140

ggactcccag acttaaaaca caaaacctaa gaattcctga cccagaactg ctagtacaaa     4200

agcaagaggg gtgtggctat agaagttgct gagagaattg ggactgtgta tctctctact     4260

ggacctgact cccctccttt gcatgttgaa atgcagaact agagttatac ccactttgaa     4320

gtgattcaga atccagagaa ggaaaagagt tctgtccaag caaaccaagg gagatggtca     4380

ctggtgactt tactttggag caatcagctg agagtctctg aatgagaacc atcgtgtgtg     4440

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg atacaactga agtttaggaa tgctcctttt     4500

atagccagaa tcagtaaaag aaaatctcac tgtcactgtc agctagacca tgtcgctact     4560

accattgctt caagtgggta tctcagttga acgggaggga aaaggtgaca gacagaaagg     4620

aacagacatt acacagtggg ctctccagcc caccagctga gaggggcttt ctggttagtg     4680

atgatcaact tcaggtggca ctggtttaga ggagacattt ttaagggaca aagtttccac     4740

cacaaaagct ttcaacggaa gagccgatct aattgtgacc atgaagccag ctgatgggtg     4800

accacacaaa cccttccccg ggaggcattt gctgttgaca caggctcctt atttctgccg     4860

cttcatacgg gagaaaaaaa aagagtggga ctttgatttg tctaagcagt tggtatgatt     4920

cacagagaga taaatcatca caggagatgg ttagcagtgt atggttctcg gcttcaacgc     4980

attgtttatt ataaaacatg cacctgggtt tatatttttc tgcctggtta taaagcaata     5040

acatcttgct atgcaaacac taaatttcat gtgtgaattt tcaactgtga ttttatgtgt     5100

gcatttttta aactaaactc tatcattttt ctatgttgac atctgttgtt ggtttggttt     5160

tgttttgttt ttaatctgtt tccaactatc tgagtctgtg aaccatctct cctgactgga     5220

tgctggcttg aaacctgtta gtgcttaaac agactcagaa acaaccctgg acctctgggg     5280

caaacgcagg ggtgttactc tttgatatat catgggccct ctgtggcttc aacaaacaaa     5340

gtcataattc ctctaaattc tgtgttttct gtaaatattt tcttcttctc agctctgcta     5400

aaatgggggt gggggggggg ggggagagag agaaactcct atcccagact ttagaccaaa     5460

aggggttgtt agagagtatg gactctggca tttctgcatt tgaagatgag gaagcctttc     5520

cagaattggg ggtacagagg ctttctctgt gcttcctggg aggtcagcaa gagggttgaa     5580

cagaaacctg aagcttcctg atgccagagc tcttgagccc acctctcccc cagcaccttg     5640

tggacgtgtg taaattcatg acacccactg taatgcctcc caagatcttc actgtgggag     5700

gcatgggagg tgatcccatg atgggctcct gccacaaaat cttccaaacc ttttaagtct     5760

gattcctgct ggagaagtta gagtccctct ttcattttca taccctctta ctctgctgtg     5820

agtgccacat tcagctgagc accacctgct tcctaagacg taaccagtgt gctggggaga     5880

tggctcagtt gataaagtgc ctgcagtgta agtgtgagga cctgaattca ggttccagca     5940

tctgtgtaag agccaggcag gaacttaagt gcaaggcggg gcaggggtgg ggataggttc     6000

attgaccaac cagtcttaag aatgaagtgg tacccaggct cattgagaga tcctgtctca     6060

aaaaataaaa atggacagag atctagggat gcacccaaca tctgccgcaa cctcccaagt     6120

catatgcgtg tgcacagaaa tccccagatc tttcttctcc cctgaaatgc aaaggtacat     6180

ttaaactatc catcctcttt cttgcccgtc ttttggcagt gagccctgcc ataacataag     6240

atccagtgag gagcagttca gccaggttgg acagtgatcc attctgttca tccttgtttg     6300

taataagcag aatttatcct gtaaggcaag gggtggtgat agccataatt tttgtcggct     6360

gggctttttt caaagtgtcc ttgaattcag caagcaaacc ttctttgaga aagctctcta     6420

aacttagtct ctctccattt ggctggaaat aatggatggc cacatccaaa ctccaaattt     6480

ctggatgtgt catatgcctc agcactacag aatctgactc tctctttgag tatagacatg     6540

cgtgttaact atgcacaggg ctgtttaaca gatggctcca atccctgctc catacttggg     6600

agcctttggt tccatcttta taccaaatgc caatcacact ggctacagag agtgtattat     6660

agtctgtgtc taagcttaga agctttaaat gtatgtttta aagaaaaaat actagagtgg     6720

gttgaacact ttaactaaac ttggaaggtt ggacagatta tgtgcaaaga tgattgtttg     6780

tttaataatg aataatctga atcctgtata acttatttgc acacctttct tgcatgatga     6840

actgacattt ttatagttgt ttgtataaga cagtggcata tttttgtaaa catttttttg     6900

acactgaact tcaataaatg tttttcctac aacaca                               6936


<210>  299
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  299
ctggattgga agaagatgt                                                    19


<210>  300
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  300
aagggcagct ggattggaa                                                    19


<210>  301
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  301
tggattggaa gaagatgta                                                    19


<210>  302
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  302
agggcagctg gattggaag                                                    19


<210>  303
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  303
acaaagggca gctggattg                                                    19


<210>  304
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  304
tcatcatttt ctatgttga                                                    19


<210>  305
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  305
tggatatctt catggataa                                                    19


<210>  306
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  306
ctaaaatcct attagtgct                                                    19


<210>  307
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  307
ggcctgcctt caaaggcct                                                    19


<210>  308
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  308
gcaagactat aagggcaat                                                    19


<210>  309
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  309
ggcagatccg caaacgatt                                                    19


<210>  310
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  310
acttctcact agaattggt                                                    19


<210>  311
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  311
tacatatatt tgcagttgt                                                    19


<210>  312
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  312
cttgggtcct tgatggctt                                                    19


<210>  313
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  313
cttggaattt caattgtct                                                    19


<210>  314
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  314
tgaaagttct tgaagacca                                                    19


<210>  315
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  315
cctgtgtgct tacaactga                                                    19


<210>  316
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  316
tgttggagct gatagcaaa                                                    19


<210>  317
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  317
ctggattcca gaagattca                                                    19


<210>  318
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  318
ccagaagatt caactacgt                                                    19


<210>  319
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  319
gcatcgccca aaagaactt                                                    19


<210>  320
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  320
cctggattcc agaagattc                                                    19


<210>  321
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  321
actgaaagtt cttgaagac                                                    19


<210>  322
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  322
aagagactct gccagtacc                                                    19


<210>  323
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  323
agcuggauug gaagaagaug u                                                 21


<210>  324
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  324
caaagggcag cuggauugga a                                                 21


<210>  325
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  325
gcuggauugg aagaagaugu a                                                 21


<210>  326
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  326
aaagggcagc uggauuggaa g                                                 21


<210>  327
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  327
agacaaaggg cagcuggauu g                                                 21


<210>  328
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  328
uaucaucauu uucuauguug a                                                 21


<210>  329
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  329
cuuggauauc uucauggaua a                                                 21


<210>  330
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  330
gccuaaaauc cuauuagugc u                                                 21


<210>  331
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  331
caggccugcc uucaaaggcc u                                                 21


<210>  332
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  332
cagcaagacu auaagggcaa u                                                 21


<210>  333
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  333
gcggcagauc cgcaaacgau u                                                 21


<210>  334
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  334
gaacuucuca cuagaauugg u                                                 21


<210>  335
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  335
uguacauaua uuugcaguug u                                                 21


<210>  336
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  336
aucuuggguc cuugauggcu u                                                 21


<210>  337
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  337
agcuuggaau uucaauuguc u                                                 21


<210>  338
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  338
acugaaaguu cuugaagacc a                                                 21


<210>  339
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  339
ugccugugug cuuacaacug a                                                 21


<210>  340
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  340
gcuguuggag cugauagcaa a                                                 21


<210>  341
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  341
uccuggauuc cagaagauuc a                                                 21


<210>  342
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  342
uuccagaaga uucaacuacg u                                                 21


<210>  343
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  343
uggcaucgcc caaaagaacu u                                                 21


<210>  344
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  344
auccuggauu ccagaagauu c                                                 21


<210>  345
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  345
guacugaaag uucuugaaga c                                                 21


<210>  346
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  346
ggaagagacu cugccaguac c                                                 21


<210>  347
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  347
acaucuucuu ccaauccagc ugc                                               23


<210>  348
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  348
uuccaaucca gcugcccuuu guc                                               23


<210>  349
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  349
uacaucuucu uccaauccag cug                                               23


<210>  350
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  350
cuuccaaucc agcugcccuu ugu                                               23


<210>  351
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  351
caauccagcu gcccuuuguc uga                                               23


<210>  352
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  352
ucaacauaga aaaugaugau aga                                               23


<210>  353
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  353
uuauccauga agauauccaa gga                                               23


<210>  354
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  354
agcacuaaua ggauuuuagg cca                                               23


<210>  355
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  355
aggccuuuga aggcaggccu ggu                                               23


<210>  356
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  356
auugcccuua uagucuugcu ggc                                               23


<210>  357
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  357
aaucguuugc ggaucugccg cuc                                               23


<210>  358
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  358
accaauucua gugagaaguu cac                                               23


<210>  359
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  359
acaacugcaa auauauguac auu                                               23


<210>  360
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  360
aagccaucaa ggacccaaga uau                                               23


<210>  361
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  361
agacaauuga aauuccaagc ucu                                               23


<210>  362
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  362
uggucuucaa gaacuuucag uac                                               23


<210>  363
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  363
ucaguuguaa gcacacaggc agg                                               23


<210>  364
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  364
uuugcuauca gcuccaacag ccu                                               23


<210>  365
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  365
ugaaucuucu ggaauccagg aug                                               23


<210>  366
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  366
acguaguuga aucuucugga auc                                               23


<210>  367
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  367
aaguucuuuu gggcgaugcc acu                                               23


<210>  368
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  368
gaaucuucug gaauccagga ugg                                               23


<210>  369
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  369
gucuucaaga acuuucagua cca                                               23


<210>  370
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  370
gguacuggca gagucucuuc cac                                               23


<210>  371
<211>  1771
<212>  DNA
<213>  Homo sapiens

<400>  371
agacagaatt cgggcaccag gagaaggaag ccaacaggat ccgacccggt gttttgtgac       60

aaaggcaaga cccccaggtc tacttagagc aaagttagta gaggaggcag ctaggcgtgg      120

ctctcattcc ttcccacaga atggattata agtcgagcct gatccaggat gggaatccca      180

tggagaactt ggagaagcag ctgatctgcc ctatctgcct ggagatgttt accaagccag      240

tggtcatctt gccgtgccag cacaacctgt gccggaagtg tgccaatgac atcttccagg      300

ctgcaaatcc ctactggacc agccggggca gctcagtgtc catgtctgga ggccgtttcc      360

gctgccccac ctgccgccac gaggtgatca tggatcgtca cggagtgtac ggcctgcaga      420

ggaacctgct ggtggagaac atcatcgaca tctacaaaca ggagtgctcc agtcggccgc      480

tgcagaaggg cagtcacccc atgtgcaagg agcacgaaga tgagaaaatc aacatctact      540

gtctcacgtg tgaggtgccc acctgctcca tgtgcaaggt gtttgggatc cacaaggcct      600

gcgaggtggc cccattgcag agtgtcttcc agggacaaaa gactgaactg aataactgta      660

tctccatgct ggtggcgggg aatgaccgtg tgcagaccat catcactcag ctggaggatt      720

cccgtcgagt gaccaaggag aacagtcacc aggtaaagga agagctgagc cagaagtttg      780

acacgttgta tgccatcctg gatgagaaga aaagtgagtt gctgcagcgg atcacgcagg      840

agcaggagaa aaagcttagc ttcatcgagg ccctcatcca gcagtaccag gagcagctgg      900

acaagtccac aaagctggtg gaaactgcca tccagtccct ggacgagcct gggggagcca      960

ccttcctctt gactgccaag caactcatca aaagcattgt ggaagcttcc aagggctgcc     1020

agctggggaa gacagagcag ggctttgaga acatggactt ctttactttg gatttagagc     1080

acatagcaga cgccctgaga gccattgact ttgggacaga tgaggaagag gaagaattca     1140

ttgaagaaga agatcaggaa gaggaagagt ccacagaagg gaaggaagaa ggacaccagt     1200

aaggagctgg atgaatgaga ggcccccaga tgcagagaga ctggagaggg tggggagggg     1260

cccagcggcc ttggtgacag gcccagggtg ggaggggtcg gggcccctgg aggggcaatg     1320

gggaggtgat gtcttctctc tgctcagaga gcagggacta gggtaggacc ctcaccgctg     1380

cgtccagcag acactgaacc agaattggaa acgtgcttga aacaatcaca caggacactt     1440

ttctacattg gtgcaaaatg gaatattttg tacattttta aaatgtgatt tttgtatata     1500

cttgtatatg tatgccaatt tggtgctttt tgtaaaggaa cttttgtata ataatgcctg     1560

gtcgttgggt gacctgcgat tgtcagaaag aggggaagga agccaggttg atacagctgc     1620

ccacttcctt tcctgagcag gaggatgggg tagcactcac agggacgatg tgctgtattt     1680

cagtgcctat cccagacata cggggtggta actgagtttg tgttatatgt tgttttaata     1740

aatgcacaat gctctcttcc tgttcttcaa a                                    1771


<210>  372
<211>  1886
<212>  DNA
<213>  Mus musculus

<400>  372
agaagtcggg ggtcagggga cgaagacaaa gaggatccga gtgggtttgg agacaaagac       60

ttggtgtgac gcaggtgggc gagacagtcg catttcaaag caatatggat tataaatcta      120

gcctgattcc tgatggaaac gctatggaga acctggagaa gcagctgatc tgccccatct      180

gcctggagat gtttaccaag cctgtggtca tcctgccctg ccaacacaac ctctgccgga      240

agtgtgccaa cgacatcttc caggctgcga atccctactg gaccaaccgc ggtggctcag      300

tgtccatgtc tggaggtcgt ttccgttgcc cctcgtgccg ccatgaagtg atcatggacc      360

ggcacggggt gtacggcctg cagaggaacc tgctggtgga aaacatcatt gacatctaca      420

agcaggagtg ctccagtcgg cccctgcaga aaggcagcca cccgatgtgc aaggaacacg      480

aagacgagaa aatcaacatc tactgtctca cgtgtgaggt gcctacttgc tccttgtgca      540

aggtgtttgg ggctcaccag gcctgtgagg ttgccccttt gcaaagcatc ttccaaggac      600

agaagactga gctgagtaac tgcatctcca tgctggtggc gggcaacgac cgagtgcaga      660

cgatcatctc tcagctggag gactcctgca gagtgaccaa ggagaatagc caccaggtga      720

aggaggagct gagtcagaag tttgacaccc tctacgccat cctggacgag aagaagagcg      780

agctgctgca gcggatcacg caggagcagg aggagaagct gggcttcatc gaggctctga      840

tcctccagta cagggagcag ctggaaaagt ccaccaaact tgtggagacc gccatccagt      900

ccctggatga gcccggaggg gctaccttcc tctcaagtgc caagcagctc atcaagagca      960

ttgtagaagc ctccaagggc tgccagctgg ggaagacaga gcaaggcttt gagaacatgg     1020

actactttac tctggactta gaacacatag cagaggcctt gagggccatt gactttggga     1080

cagatgagga ggaggaggag gaggagttta cagaagagga ggctgatgag gaagagggcg     1140

tgaccacaga gggtaaagaa gaacaccaat gaagaaggag atgagtgaga cacgctctgg     1200

acgcagagac gggggaggtg ggggcaggcc catctcggga gggggttagg gctccttggg     1260

gggtacaata gggaagtgtg tcttctctct gctcagagag cagggactag catagggctc     1320

cccaccactg tgtccagcag ctgctgaaac acaattggaa atgtatccaa aacgtcacag     1380

gacacttttc tacgttggtg cgaaatgaaa tattttgtat gtttttaaaa tgtgattttt     1440

gtatatactt gtatatgtat gccaatttgg tgctttttgt acgagaactt ttgtatgatc     1500

acgcctggtc attgtgtgac tggcgattgt cacaaagtgg gaaggaagcc aagacaatag     1560

agatgcctac ttcctttcct tggtgggagg gctgggtctc actcggtggc ctagagaggg     1620

gcaatgtact gtacagtgcc catccccaaa catggggata ggactgaatt tgtgttatat     1680

gttgttttgc acaaggggct gggccttggg gcacacaccc tttgatccca gcactctgga     1740

ggcagaggca gttggatctc tatgagttca aggccagcct ggtctacatg gagagttaca     1800

ggccagccag agctacatag agagactctg cctcaaaaat aaaaatgaaa aagaataaaa     1860

aataaactca caatgctctt ttcctg                                          1886


<210>  373
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  373
tatgtatgcc aatttggtg                                                    19


<210>  374
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  374
aacatctact gtctcacgt                                                    19


<210>  375
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  375
tatatgtatg ccaatttgg                                                    19


<210>  376
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  376
agtttgtgtt atatgttgt                                                    19


<210>  377
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  377
aaaggaactt ttgtataat                                                    19


<210>  378
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  378
aataaatgca caatgctct                                                    19


<210>  379
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  379
agaatggatt ataagtcga                                                    19


<210>  380
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  380
gcctgatcca ggatgggaa                                                    19


<210>  381
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  381
gagcaaagtt agtagagga                                                    19


<210>  382
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  382
gcaaggtgtt tgggatcca                                                    19


<210>  383
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  383
accaggtaaa ggaagagct                                                    19


<210>  384
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  384
agcagacact gaaccagaa                                                    19


<210>  385
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  385
gctccatgtg caaggtgtt                                                    19


<210>  386
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  386
aatttgtgtt atatgttgt                                                    19


<210>  387
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  387
gactgaattt gtgttatat                                                    19


<210>  388
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  388
cctacttgct ccttgtgca                                                    19


<210>  389
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  389
gcaaggaaca cgaagacga                                                    19


<210>  390
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  390
ttgagaacat ggactactt                                                    19


<210>  391
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  391
aggactgaat ttgtgttat                                                    19


<210>  392
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  392
cttgctcctt gtgcaaggt                                                    19


<210>  393
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  393
cggaagtgtg ccaacgaca                                                    19


<210>  394
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  394
tcaacatcta ctgtctcac                                                    19


<210>  395
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  395
tcaagagcat tgtagaagc                                                    19


<210>  396
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  396
acttgtatat gtatgccaa                                                    19


<210>  397
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  397
uauauguaug ccaauuuggu g                                                 21


<210>  398
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  398
ucaacaucua cugucucacg u                                                 21


<210>  399
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  399
uguauaugua ugccaauuug g                                                 21


<210>  400
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  400
ugaguuugug uuauauguug u                                                 21


<210>  401
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  401
guaaaggaac uuuuguauaa u                                                 21


<210>  402
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  402
uuaauaaaug cacaaugcuc u                                                 21


<210>  403
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  403
acagaaugga uuauaagucg a                                                 21


<210>  404
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  404
gagccugauc caggauggga a                                                 21


<210>  405
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  405
uagagcaaag uuaguagagg a                                                 21


<210>  406
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  406
gugcaaggug uuugggaucc a                                                 21


<210>  407
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  407
ucaccaggua aaggaagagc u                                                 21


<210>  408
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  408
ccagcagaca cugaaccaga a                                                 21


<210>  409
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  409
cugcuccaug ugcaaggugu u                                                 21


<210>  410
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  410
ugaauuugug uuauauguug u                                                 21


<210>  411
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  411
aggacugaau uuguguuaua u                                                 21


<210>  412
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  412
ugccuacuug cuccuugugc a                                                 21


<210>  413
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  413
gugcaaggaa cacgaagacg a                                                 21


<210>  414
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  414
cuuugagaac auggacuacu u                                                 21


<210>  415
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  415
auaggacuga auuuguguua u                                                 21


<210>  416
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  416
uacuugcucc uugugcaagg u                                                 21


<210>  417
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  417
gccggaagug ugccaacgac a                                                 21


<210>  418
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  418
aaucaacauc uacugucuca c                                                 21


<210>  419
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  419
caucaagagc auuguagaag c                                                 21


<210>  420
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  420
auacuuguau auguaugcca a                                                 21


<210>  421
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  421
caccaaauug gcauacauau aca                                               23


<210>  422
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  422
acgugagaca guagauguug auu                                               23


<210>  423
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  423
ccaaauuggc auacauauac aag                                               23


<210>  424
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  424
acaacauaua acacaaacuc agu                                               23


<210>  425
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  425
auuauacaaa aguuccuuua caa                                               23


<210>  426
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  426
agagcauugu gcauuuauua aaa                                               23


<210>  427
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  427
ucgacuuaua auccauucug ugg                                               23


<210>  428
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  428
uucccauccu ggaucaggcu cga                                               23


<210>  429
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  429
uccucuacua acuuugcucu aag                                               23


<210>  430
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  430
uggaucccaa acaccuugca cau                                               23


<210>  431
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  431
agcucuuccu uuaccuggug acu                                               23


<210>  432
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  432
uucugguuca gugucugcug gac                                               23


<210>  433
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  433
aacaccuugc acauggagca ggu                                               23


<210>  434
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  434
acaacauaua acacaaauuc agu                                               23


<210>  435
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  435
auauaacaca aauucagucc uau                                               23


<210>  436
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  436
ugcacaagga gcaaguaggc acc                                               23


<210>  437
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  437
ucgucuucgu guuccuugca cau                                               23


<210>  438
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  438
aaguagucca uguucucaaa gcc                                               23


<210>  439
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  439
auaacacaaa uucaguccua ucc                                               23


<210>  440
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  440
accuugcaca aggagcaagu agg                                               23


<210>  441
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  441
ugucguuggc acacuuccgg cag                                               23


<210>  442
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  442
gugagacagu agauguugau uuu                                               23


<210>  443
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  443
gcuucuacaa ugcucuugau gag                                               23


<210>  444
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  444
uuggcauaca uauacaagua uau                                               23


<210>  445
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Pro Phe Leu Gly Gln Asp Trp Arg Ser Pro Gly Gln Asn Trp Val 
1               5                   10                  15      


Lys Thr Ala Asp Gly Trp Lys Arg Phe Leu Asp Glu Lys Ser Gly Ser 
            20                  25                  30          


Phe Val Ser Asp Leu Ser Ser Tyr Cys Asn Lys Glu Val Tyr Asn Lys 
        35                  40                  45              


Glu Asn Leu Phe Asn Ser Leu Asn Tyr Asp Val Ala Ala Lys Lys Arg 
    50                  55                  60                  


Lys Lys Asp Met Leu Asn Ser Lys Thr Lys Thr Gln Tyr Phe His Gln 
65                  70                  75                  80  


Glu Lys Trp Ile Tyr Val His Lys Gly Ser Thr Lys Glu Arg His Gly 
                85                  90                  95      


Tyr Cys Thr Leu Gly Glu Ala Phe Asn Arg Leu Asp Phe Ser Thr Ala 
            100                 105                 110         


Ile Leu Asp Ser Arg Arg Phe Asn Tyr Val Val Arg Leu Leu Glu Leu 
        115                 120                 125             


Ile Ala Lys Ser Gln Leu Thr Ser Leu Ser Gly Ile Ala Gln Lys Asn 
    130                 135                 140                 


Phe Met Asn Ile Leu Glu Lys Val Val Leu Lys Val Leu Glu Asp Gln 
145                 150                 155                 160 


Gln Asn Ile Arg Leu Ile Arg Glu Leu Leu Gln Thr Leu Tyr Thr Ser 
                165                 170                 175     


Leu Cys Thr Leu Val Gln Arg Val Gly Lys Ser Val Leu Val Gly Asn 
            180                 185                 190         


Ile Asn Met Trp Val Tyr Arg Met Glu Thr Ile Leu His Trp Gln Gln 
        195                 200                 205             


Gln Leu Asn Asn Ile Gln Ile Thr Arg Pro Ala Phe Lys Gly Leu Thr 
    210                 215                 220                 


Phe Thr Asp Leu Pro Leu Cys Leu Gln Leu Asn Ile Met Gln Arg Leu 
225                 230                 235                 240 


Ser Asp Gly Arg Asp Leu Val Ser Leu Gly Gln Ala Ala Pro Asp Leu 
                245                 250                 255     


His Val Leu Ser Glu Asp Arg Leu Leu Trp Lys Lys Leu Cys Gln Tyr 
            260                 265                 270         


His Phe Ser Glu Arg Gln Ile Arg Lys Arg Leu Ile Leu Ser Asp Lys 
        275                 280                 285             


Gly Gln Leu Asp Trp Lys Lys Met Tyr Phe Lys Leu Val Arg Cys Tyr 
    290                 295                 300                 


Pro Arg Lys Glu Gln Tyr Gly Asp Thr Leu Gln Leu Cys Lys His Cys 
305                 310                 315                 320 


His Ile Leu Ser Trp Lys Gly Thr Asp His Pro Cys Thr Ala Asn Asn 
                325                 330                 335     


Pro Glu Ser Cys Ser Val Ser Leu Ser Pro Gln Asp Phe Ile Asn Leu 
            340                 345                 350         


Phe Lys Phe 
        355 


<210>  446
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
1               5                   10                  15      


Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
            20                  25                  30          


Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
        35                  40                  45              


Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
    50                  55                  60                  


Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
65                  70                  75                  80  


Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                85                  90                  95      


Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
            100                 105                 110         


Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
        115                 120                 125             


Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
    130                 135                 140                 


Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
145                 150                 155                 160 


Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                165                 170                 175     


Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
            180                 185                 190         


Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
        195                 200                 205             


Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
    210                 215                 220                 


Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
225                 230                 235                 240 


Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                245                 250                 255     


Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
            260                 265                 270         


Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
        275                 280                 285             


Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
    290                 295                 300                 


Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
305                 310                 315                 320 


Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                325                 330                 335     


Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
            340                 345                 350         


Gln 
    


<210>  447
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified by 2'Fluoro

<400>  447
uccuaugacu guagauuuua u                                                 21


<210>  448
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  modified by 2'OMe

<400>  448
auaaaaucua cagucauagg aau                                               23


<210>  449
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified by 2'Fluoro

<400>  449
uguaauaacc auaucuaccu u                                                 21


<210>  450
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified by 2'OMe

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  modified by 2'Fluoro

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  modified by 2'OMe

<400>  450
aagguagaua ugguuauuac aaa                                               23


<210>  451
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  451

Leu Pro Xaa Thr Gly 
1               5   


<210>  452
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  452

Thr Ala Arg Gly Glu His Lys Glu Glu Glu Leu Ile 
1               5                   10          


<210>  453
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  453

Gly Tyr Thr Phe Thr Asn Tyr Trp Met His 
1               5                   10  


<210>  454
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  454

Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Gly Glu Arg Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  455
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  455

Gly Thr Arg Ala Met His Tyr 
1               5           


<210>  456
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  456

Arg Thr Ser Glu Asn Ile Tyr Asn Asn Leu Ala 
1               5                   10      


<210>  457
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  457

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  458
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  458

Gln His Phe Trp Gly Thr Pro Leu Thr Phe 
1               5                   10  


<210>  459
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  459

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Gly Glu Arg Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  460
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  460

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  461
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  461

Tyr Thr Phe Thr Asn Tyr Trp Met His 
1               5                   


<210>  462
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  462

Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  463
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  463

Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  464
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  464

Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  465
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  465

Gln His Phe Trp Gly Thr Pro Leu Thr 
1               5                   


<210>  466
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  466

Ala Ala Thr Asn Leu Ala Glu 
1               5           


<210>  467
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  467

Arg Thr Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  468
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  468

Ala Gly Thr Asn Leu Ala Asp 
1               5           


<210>  469
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  469

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  470
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  470

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  471
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  471

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Gln Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  472
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  472

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Ile Asn Gly Arg Ser Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Arg Ala Met His Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  473
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  473

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  474
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  474

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  475
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  475

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  476
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  476

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Gly Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


