
                                SEQUENCE LISTING

<110> Schnappinger, Dirk
      Ehrt, Sabine
      Cornell University
      

<120> CONDITIONALLY REPLICATING M. BOVIS BCG
  
  

<130> 1676.151WO1

<140> PCT/US2021/012671   
<141> 2021-01-08  

<150> US 62/959,485       
<151> 2020-01-10  

<160> 29

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 207
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 1
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu
 1               5                  10                  15
Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln
            20                  25                  30
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys
        35                  40                  45
Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His
    50                  55                  60
Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg
65                  70                  75                  80
Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly
                85                  90                  95
Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr
            100                 105                 110
Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu
        115                 120                 125
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
    130                 135                 140
Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr
145                 150                 155                 160
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu
                165                 170                 175
Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
            180                 185                 190
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser
        195                 200                 205

<210> 2
<211> 204
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 2
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu
 1               5                  10                  15
Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln
            20                  25                  30
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys
        35                  40                  45
Arg Ala Leu Met Asn Met Leu Ser Glu Ala Ile Leu Ala Lys His His
    50                  55                  60
Thr Arg Ser Ala Pro Leu Pro Thr Glu Ser Trp Gln Gln Phe Leu Gln
65                  70                  75                  80
Glu Asn Ala Leu Ser Phe Arg Lys Ala Leu Leu Val His Arg Asp Gly
                85                  90                  95
Ala Arg Leu His Ile Gly Thr Ser Pro Thr Pro Pro Gln Phe Glu Gln
            100                 105                 110
Ala Glu Ala Gln Leu Arg Cys Leu Cys Asp Ala Gly Phe Ser Val Glu
        115                 120                 125
Glu Ala Leu Phe Ile Leu Gln Ser Ile Ser His Phe Thr Leu Gly Ala
    130                 135                 140
Val Leu Glu Glu Gln Ala Thr Asn Gln Ile Glu Asn Asn His Val Ile
145                 150                 155                 160
Asp Ala Ala Pro Pro Leu Leu Gln Glu Ala Phe Asn Ile Gln Ala Arg
                165                 170                 175
Thr Ser Ala Glu Met Ala Phe His Phe Gly Leu Lys Ser Leu Ile Phe
            180                 185                 190
Gly Phe Ser Ala Gln Leu Asp Glu Lys Ser Gly Ser
        195                 200

<210> 3
<211> 207
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 3
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Ala Leu
 1               5                  10                  15
Gly Asn Glu Val Gly Ile Glu Gly Val Thr Thr Arg Lys Leu Ala Gln
            20                  25                  30
Lys Leu Gly Val Ala Gln Lys Thr Leu Tyr Trp His Val Lys Asn Lys
        35                  40                  45
Arg Ala Leu Leu Asp Ala Leu Ala Val Glu Ile Leu Ala Arg His His
    50                  55                  60
Asp Tyr Ser Leu Pro Ala Ala Gly Glu Ser Trp Gln Ser Phe Leu Arg
65                  70                  75                  80
Asn Asn Ala Met Ser Phe Arg Arg Ala Leu Leu Arg Tyr Arg Asp Gly
                85                  90                  95
Ala Lys Val His Leu Gly Thr Arg Pro Asp Glu Lys Gln Tyr Asp Thr
            100                 105                 110
Val Glu Thr Gln Leu Arg Phe Met Thr Glu Asn Gly Phe Ser Leu Glu
        115                 120                 125
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
    130                 135                 140
Val Leu Glu Asp Gln Glu His Thr Ala Ala Lys Glu Glu Arg Glu Thr
145                 150                 155                 160
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu
                165                 170                 175
Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
            180                 185                 190
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser
        195                 200                 205

<210> 4
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 4
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu
 1               5                  10                  15
Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln
            20                  25                  30
Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys
        35                  40                  45
Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His
    50                  55                  60
Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg
65                  70                  75                  80
Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly
                85                  90                  95
Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr
            100                 105                 110
Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu
        115                 120                 125
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
    130                 135                 140
Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr
145                 150                 155                 160
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu
                165                 170                 175
Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
            180                 185                 190
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Asp Ser
        195                 200                 205
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    210                 215                 220
Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Arg Leu Asp Lys Ser
225                 230                 235                 240
Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly Ile Glu
                245                 250                 255
Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro
            260                 265                 270
Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu
        275                 280                 285
Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu
    290                 295                 300
Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg
305                 310                 315                 320
Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr
                325                 330                 335
Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe
            340                 345                 350
Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser
        355                 360                 365
Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu His
    370                 375                 380
Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro
385                 390                 395                 400
Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala Glu
                405                 410                 415
Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys
            420                 425                 430
Gln Leu Lys Cys Glu Ser Gly Ser
        435                 440

<210> 5
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 5
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Ala Leu
 1               5                  10                  15
Gly Asn Glu Val Gly Ile Glu Gly Val Thr Thr Arg Lys Leu Ala Gln
            20                  25                  30
Lys Leu Gly Val Ala Gln Lys Thr Leu Tyr Trp His Val Lys Asn Lys
        35                  40                  45
Arg Ala Leu Leu Asp Ala Leu Ala Val Glu Ile Leu Ala Arg His His
    50                  55                  60
Asp Tyr Ser Leu Pro Ala Ala Gly Glu Ser Trp Gln Ser Phe Leu Arg
65                  70                  75                  80
Asn Asn Ala Met Ser Phe Arg Arg Ala Leu Leu Arg Tyr Arg Asp Gly
                85                  90                  95
Ala Lys Val His Leu Gly Thr Arg Pro Asp Glu Lys Gln Tyr Asp Thr
            100                 105                 110
Val Glu Thr Gln Leu Arg Phe Met Thr Glu Asn Gly Phe Ser Leu Glu
        115                 120                 125
Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys
    130                 135                 140
Val Leu Glu Asp Gln Glu His Thr Ala Ala Lys Glu Glu Arg Glu Thr
145                 150                 155                 160
Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu
                165                 170                 175
Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu
            180                 185                 190
Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Gly
        195                 200                 205
Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    210                 215                 220
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Leu Asp Lys Ser
225                 230                 235                 240
Lys Val Ile Asn Ser Ala Leu Ala Leu Gly Asn Glu Val Gly Ile Glu
                245                 250                 255
Gly Val Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Ala Gln Lys
            260                 265                 270
Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu
        275                 280                 285
Ala Val Glu Ile Leu Ala Arg His His Asp Tyr Ser Leu Pro Ala Ala
    290                 295                 300
Gly Glu Ser Trp Gln Ser Phe Leu Arg Asn Asn Ala Met Ser Phe Arg
305                 310                 315                 320
Arg Ala Leu Leu Arg Tyr Arg Asp Gly Ala Lys Val His Leu Gly Thr
                325                 330                 335
Arg Pro Asp Glu Lys Gln Tyr Asp Thr Val Glu Thr Gln Leu Arg Phe
            340                 345                 350
Met Thr Glu Asn Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser
        355                 360                 365
Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu His
    370                 375                 380
Thr Ala Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro
385                 390                 395                 400
Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala Glu
                405                 410                 415
Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys
            420                 425                 430
Gln Leu Lys Cys Glu Ser Gly Ser
        435                 440

<210> 6
<211> 252
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 6
Met Ala Lys Ala Gly Arg Glu Gly Pro Arg Asp Ser Val Trp Leu Ser
 1               5                  10                  15
Gly Glu Gly Arg Arg Gly Gly Arg Arg Gly Gly Gln Pro Ser Gly Leu
            20                  25                  30
Asp Arg Asp Arg Ile Thr Gly Val Thr Val Arg Leu Leu Asp Thr Glu
        35                  40                  45
Gly Leu Thr Gly Phe Ser Met Arg Arg Leu Ala Ala Glu Leu Asn Val
    50                  55                  60
Thr Ala Met Ser Val Tyr Trp Tyr Val Asp Thr Lys Asp Gln Leu Leu
65                  70                  75                  80
Glu Leu Ala Leu Asp Ala Val Phe Gly Glu Leu Arg His Pro Asp Pro
                85                  90                  95
Asp Ala Gly Leu Asp Trp Arg Glu Glu Leu Arg Ala Leu Ala Arg Glu
            100                 105                 110
Asn Arg Ala Leu Leu Val Arg His Pro Trp Ser Ser Arg Leu Val Gly
        115                 120                 125
Thr Tyr Leu Asn Ile Gly Pro His Ser Leu Ala Phe Ser Arg Ala Val
    130                 135                 140
Gln Asn Val Val Arg Arg Ser Gly Leu Pro Ala His Arg Leu Thr Gly
145                 150                 155                 160
Ala Ile Ser Ala Val Phe Gln Phe Val Tyr Gly Tyr Gly Thr Ile Glu
                165                 170                 175
Gly Arg Phe Leu Ala Arg Val Ala Asp Thr Gly Leu Ser Pro Glu Glu
            180                 185                 190
Tyr Phe Gln Asp Ser Met Thr Ala Val Thr Glu Val Pro Asp Thr Ala
        195                 200                 205
Gly Val Ile Glu Asp Ala Gln Asp Ile Met Ala Ala Arg Gly Gly Asp
    210                 215                 220
Thr Val Ala Glu Met Leu Asp Arg Asp Phe Glu Phe Ala Leu Asp Leu
225                 230                 235                 240
Leu Val Ala Gly Ile Asp Ala Met Val Glu Gln Ala
                245                 250

<210> 7
<211> 90
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 7
Met Asn Lys Ala Val Ile Asn Gly Glu Gln Ile Arg Ser Met Ser Asp
 1               5                  10                  15
Leu His Gln Thr Leu Lys Lys Glu Leu Ala Leu Pro Glu Tyr Tyr Gly
            20                  25                  30
Glu Asn Leu Asp Ala Leu Trp Asp Cys Leu Thr Gly Trp Val Glu Tyr
        35                  40                  45
Pro Leu Val Leu Glu Trp Arg Gln Phe Glu Gln Ser Lys Gln Leu Thr
    50                  55                  60
Glu Asn Gly Ala Glu Ser Val Leu Gln Val Phe Arg Glu Ala Lys Ala
65                  70                  75                  80
Glu Gly Cys Asp Ile Thr Ile Ile Leu Ser
                85                  90

<210> 8

<400> 8
 000

<210> 9

<400> 9
 000

<210> 10
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 10
tctgaccagg gaaaatagcc ctctgacctg gggatttgac ttccctatca gtgatagaga      60
taatctggga g                                                           71

<210> 11
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 11
tctgaccagg gaaaatagcc ctctgacctg gggatttgac ttccctatca gtgatagaga      60
caatctggga g                                                           71

<210> 12
<211> 70
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 12
ctgaccaggg aaaatagccc tctgacctgg ggatttgact tccccgtcag tgacggagat      60
aatctgggag                                                             70

<210> 13
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 13
tctgaccagg gaaaatagcc ctctgacctg gggatttgac ttccccgtca gtgacggaga      60
caatctggga g                                                           71

<210> 14
<211> 231
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 14
tgcatgctgg atccactggt tcatcggcgg cggtgacggg ccgggcggcg gcgccggcgg      60
cgggacgagt tccgagatca ccgcctgggt ccaggacgag ttcaccccgg tcacggtgga     120
cggcgtcacc ttctacgacc tgaccgcgga gaaatagcgc tgtacagcgt atgggaatct     180
cttgtacggt gtacgagtat cttcccgtac accgtacaag gagcctgaac c              231

<210> 15
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 15
tctgaccagg gaaaatagcc ctctgacctg gggatttgtc ctgcgtgtgc tcggtcgata      60
ggctctggga g                                                           71

<210> 16

<400> 16
 000

<210> 17

<400> 17
 000

<210> 18

<400> 18
 000

<210> 19

<400> 19
 000

<210> 20
<211> 292
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 20
Met Thr Phe Thr Val Thr Arg Glu Arg Ala Gln Trp Val His Asp Met
 1               5                  10                  15
Ala Arg Ala Arg Asp Gly Leu Pro Tyr Ala Tyr Gly Gly Ala Phe Thr
            20                  25                  30
Asn Asn Pro Arg Val Ser Thr Asp Cys Ser Gly Leu Val Leu Gln Thr
        35                  40                  45
Gly Ala Trp Tyr Gly Gly Arg Thr Asp Trp Val Gly Asn Arg Tyr Gly
    50                  55                  60
Ser Thr Glu Ser Phe Arg Leu Asp His Lys Ile Val Tyr Asp Leu Gly
65                  70                  75                  80
Phe Lys Arg Met Pro Arg Gly Gly Pro Ala Ala Leu Pro Ile Lys Pro
                85                  90                  95
Val Met Leu Val Gly Leu Gln His Gly Gly Gly Gly Val Tyr Ser His
            100                 105                 110
Thr Ala Cys Thr Leu Met Thr Met Asp His Pro Gly Gly Pro Val Lys
        115                 120                 125
Met Ser Asp Arg Gly Val Asp Trp Glu Ser His Gly Asn Arg Asn Gly
    130                 135                 140
Val Gly Val Glu Leu Tyr Glu Gly Ala Arg Ala Trp Asn Asp Pro Leu
145                 150                 155                 160
Phe His Asp Phe Trp Tyr Leu Asp Ala Val Leu Glu Asp Glu Gly Asp
                165                 170                 175
Asp Asp Glu Leu Ala Asp Pro Val Leu Gly Lys Met Ile Arg Glu Ile
            180                 185                 190
His Ala Cys Leu Phe Asn Gln Thr Ala Ser Thr Ser Asp Leu Ala Thr
        195                 200                 205
Pro Gly Glu Gly Ala Ile Trp Gln Leu His Gln Lys Ile His Ser Ile
    210                 215                 220
Asp Gly Met Leu His Pro Ile His Ala Glu Arg Arg Ala Arg Ala Gly
225                 230                 235                 240
Asp Leu Gly Glu Leu His Arg Ile Val Leu Ala Ala Lys Gly Leu Gly
                245                 250                 255
Val Lys Arg Asp Glu Val Thr Lys Arg Val Tyr Gln Ser Ile Leu Ala
            260                 265                 270
Asp Ile Glu Arg Asp Asn Pro Glu Val Leu Gln Arg Tyr Ile Ala Glu
        275                 280                 285
Arg Gly Gly Leu
    290

<210> 21
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 21
Met Ser Pro Lys Ile Arg Gln Thr Ile Tyr Leu Leu Gly Thr Ala Ala
 1               5                  10                  15
Pro Ala Leu Leu Gly Ile Val Leu Ile Trp Gly Gly Leu Asp Ala Glu
            20                  25                  30
Ser Ala Ala Asp Leu Gly Asp Ile Ile Ala Gly Val Val Ser Ile Leu
        35                  40                  45
Val Ser Gly Ala Pro Ala Val Ala Ala Gly Thr Val Arg Ser Gln Arg
    50                  55                  60
Lys Asp Gly Thr Leu Ser Thr Ser Pro Val Asp Gln Val Thr Lys Gly
65                  70                  75                  80
Val Glu Gln Val Leu Ala Ala Arg Gln Ser Ala Glu Ala Glu Val Ala
                85                  90                  95
Lys Val Lys Gln Ala Leu Glu Thr Ala Val Ser Gly Ser Leu Pro Gln
            100                 105                 110
Leu Gly Pro Leu Ala Thr Gln Ile Leu Asn Val Ala Asp Asp Thr Val
        115                 120                 125
Trp Arg Pro
    130

<210> 22
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 22
Met Ser Lys Pro Trp Leu Phe Thr Val His Gly Thr Gly Gln Pro Asp
 1               5                  10                  15
Pro Leu Gly Pro Gly Leu Pro Ala Asp Thr Ala Arg Asp Val Leu Asp
            20                  25                  30
Ile Tyr Arg Trp Gln Pro Ile Gly Asn Tyr Pro Ala Ala Ala Phe Pro
        35                  40                  45
Met Trp Pro Ser Val Glu Lys Gly Val Ala Glu Leu Ile Leu Gln Ile
    50                  55                  60
Glu Leu Lys Leu Asp Ala Asp Pro Tyr Ala Asp Phe Ala Leu Ala Gly
65                  70                  75                  80
Tyr Ser Gln Gly Ala Ile Val Val Gly Gln Val Leu Lys His His Ile
                85                  90                  95
Ile Asn Pro Arg Gly Arg Leu His Arg Phe Leu His Arg Leu Arg Lys
            100                 105                 110
Val Ile Phe Trp Gly Asn Pro Met Arg Gln Lys Gly Phe Ala His Thr
        115                 120                 125
Asp Glu Trp Ile His Gln Val Ala Ala Ser Asp Thr Met Gly Ile Leu
    130                 135                 140
Glu Asp Arg Leu Glu Asn Leu Glu Gln Tyr Gly Phe Glu Val Arg Asp
145                 150                 155                 160
Tyr Ala His Asp Gly Asp Met Tyr Ala Ser Ile Lys Glu Asp Asp Met
                165                 170                 175
His Glu Tyr Glu Val Ala Ile Gly Arg Ile Val Met Ser Ala Arg Arg
            180                 185                 190
Phe Ile Gly Gly Lys Asp Ser Val Ile Ala Gln Leu Ile Glu Leu Gly
        195                 200                 205
Gln Arg Pro Ile Trp Glu Gly Ile Ala Met Ala Arg Ala Ile Ile Asp
    210                 215                 220
Ala Leu Thr Phe Phe Ala Lys Ser Thr Gln Gly Pro Ser Trp Pro His
225                 230                 235                 240
Leu Tyr Asn Arg Phe Pro Ala Val Glu Phe Leu Arg Arg Ile
                245                 250

<210> 23
<211> 493
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 23
Met Thr Leu Ile Val Thr Arg Asp His Ala Gln Trp Val His Asp Met
 1               5                  10                  15
Cys Arg Ala Arg Ala Gly Asn Arg Tyr Gly Tyr Gly Gly Ala Phe Thr
            20                  25                  30
Leu Asn Pro Arg Asp Thr Thr Asp Cys Ser Gly Leu Val Leu Gln Thr
        35                  40                  45
Ala Ala Trp Tyr Gly Gly Arg Lys Asp Trp Ile Gly Asn Arg Tyr Gly
    50                  55                  60
Ser Thr Glu Ser Phe Arg Leu Asp His Lys Ile Val Tyr Asp Leu Gly
65                  70                  75                  80
Phe Arg Arg Leu Pro Pro Gly Gly Val Ala Ala Leu Gly Phe Thr Pro
                85                  90                  95
Val Met Leu Val Gly Leu Gln His Gly Gly Gly Gly Arg Tyr Ser His
            100                 105                 110
Thr Ala Cys Thr Leu Met Thr Met Asp Ile Pro Gly Gly Pro Val Lys
        115                 120                 125
Val Ser Gln Arg Gly Val Asp Trp Glu Ser Arg Gly Glu Val Asn Gly
    130                 135                 140
Val Gly Val Phe Leu Tyr Asp Gly Ala Arg Ala Trp Asn Asp Pro Leu
145                 150                 155                 160
Phe His Asp Phe Trp Tyr Leu Asp Ala Lys Leu Glu Asp Gly Pro Thr
                165                 170                 175
Gln Ser Val Asp Ala Ala Glu Ile Leu Ala Arg Ala Thr Gly Leu Ala
            180                 185                 190
Tyr Asn Arg Ala Val Ala Leu Leu Pro Ala Val Arg Asp Gly Leu Ile
        195                 200                 205
Gln Ala Asp Cys Thr Asn Pro Asn Arg Ile Ala Met Trp Leu Ala Gln
    210                 215                 220
Ile Gly His Glu Ser Asp Asp Phe Lys Ala Thr Ala Glu Tyr Ala Ser
225                 230                 235                 240
Gly Asp Ala Tyr Asp Thr Arg Thr Asp Leu Gly Asn Thr Pro Glu Val
                245                 250                 255
Asp Gly Asp Gly Arg Leu Tyr Lys Gly Arg Ser Trp Ile Met Ile Thr
            260                 265                 270
Gly Lys Asp Asn Tyr Arg Asp Phe Ser Arg Trp Ala His Gly Arg Gly
        275                 280                 285
Leu Val Pro Thr Pro Asp Tyr Phe Val Val His Pro Leu Glu Leu Ser
    290                 295                 300
Glu Leu Arg Trp Ala Gly Ile Gly Ala Ala Trp Tyr Trp Thr Val Glu
305                 310                 315                 320
Arg Pro Asp Ile Asn Ala Leu Ser Asp Arg Arg Asp Leu Glu Thr Val
                325                 330                 335
Thr Arg Arg Ile Asn Gly Gly Leu Thr Asn Leu Asp Asp Arg Arg Arg
            340                 345                 350
Arg Tyr Asn Leu Ala Leu Ala Val Gly Asp Gln Leu Leu Thr Leu Ile
        355                 360                 365
Gly Asp Asp Asp Glu Leu Ala Asp Pro Thr Ile Gln Arg Phe Ile Arg
    370                 375                 380
Glu Ile His Gly Ala Leu Phe Asn Thr Val Val Thr Gln Ser Pro Tyr
385                 390                 395                 400
Gly Asp Pro Gln Asn Pro Asp Gly Ser Glu Pro Arg Ser Asn Leu Trp
                405                 410                 415
Gln Leu His Glu Leu Ile Lys Asn Gly Asp Gly Met Gly His Ala Arg
            420                 425                 430
Tyr Val Glu Glu Ser Ala Arg Ala Gly Asp Leu Arg Glu Leu Glu Arg
        435                 440                 445
Val Val Arg Ala Ala Lys Gly Leu Gly Arg Asp Arg Ser Pro Glu Phe
    450                 455                 460
Ile Ala Arg Ala Arg Asn Val Leu Ala Gln Ile Glu Ala Ala Asn Pro
465                 470                 475                 480
Glu Tyr Leu Gln Ala Tyr Ile Ala Arg Asn Gly Ala Leu
                485                 490

<210> 24
<211> 141
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 24
Met Ser Pro Lys Ile Arg Glu Thr Leu Tyr Tyr Val Gly Thr Leu Val
 1               5                  10                  15
Pro Gly Ile Leu Gly Ile Ala Leu Ile Trp Gly Gly Ile Asp Ala Gly
            20                  25                  30
Ala Ala Ala Asn Ile Gly Asp Ile Val Ala Gly Ala Leu Asn Leu Val
        35                  40                  45
Gly Ala Ala Ala Pro Ala Thr Ala Ala Val Lys Val Asn Gln Gln Arg
    50                  55                  60
Lys Asp Gly Thr Leu Thr Thr Ser Pro Val Asp Gln Val Thr Arg Gly
65                  70                  75                  80
Val Glu Gln Val Leu Ala Ala Lys Gln Asn Ala Glu Ala Glu Val Glu
                85                  90                  95
Arg Val Lys Gln Ala Leu Glu Ser Ala Val Asn Gly Ala Val Pro Gln
            100                 105                 110
Leu Gly Pro Leu Ala Ser Gln Ile Leu Asn Gly Ile Gln Pro Ala Tyr
        115                 120                 125
Ser Gln Pro Phe Asp Pro His Thr Gln Pro Trp Asn Arg
    130                 135                 140

<210> 25
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 25
Met Ser Lys Pro Trp Leu Phe Thr Val His Gly Thr Gly Gln Pro Asp
 1               5                  10                  15
Pro Leu Gly Pro Gly Leu Pro Ala Asp Thr Ala Arg Asp Val Leu Asp
            20                  25                  30
Ile Tyr Arg Trp Gln Pro Ile Gly Asn Tyr Pro Ala Ala Ala Phe Pro
        35                  40                  45
Met Trp Pro Ser Val Glu Lys Gly Val Ala Glu Leu Ile Leu Gln Ile
    50                  55                  60
Glu Leu Lys Leu Asp Ala Asp Pro Tyr Ala Asp Phe Ala Met Ala Gly
65                  70                  75                  80
Tyr Ser Gln Gly Ala Ile Val Val Gly Gln Val Leu Lys His His Ile
                85                  90                  95
Leu Pro Pro Thr Gly Arg Leu His Arg Phe Leu His Arg Leu Lys Lys
            100                 105                 110
Val Ile Phe Trp Gly Asn Pro Met Arg Gln Lys Gly Phe Ala His Ser
        115                 120                 125
Asp Glu Trp Ile His Pro Val Ala Ala Pro Asp Thr Leu Gly Ile Leu
    130                 135                 140
Glu Asp Arg Leu Glu Asn Leu Glu Gln Tyr Gly Phe Glu Val Arg Asp
145                 150                 155                 160
Tyr Ala His Asp Gly Asp Met Tyr Ala Ser Ile Lys Glu Asp Asp Leu
                165                 170                 175
His Glu Tyr Glu Val Ala Ile Gly Arg Ile Val Met Lys Ala Ser Gly
            180                 185                 190
Phe Ile Gly Gly Arg Asp Ser Val Val Ala Gln Leu Ile Glu Leu Gly
        195                 200                 205
Gln Arg Pro Ile Thr Glu Gly Ile Ala Leu Ala Gly Ala Ile Ile Asp
    210                 215                 220
Ala Leu Thr Phe Phe Ala Arg Ser Arg Met Gly Asp Lys Trp Pro His
225                 230                 235                 240
Leu Tyr Asn Arg Tyr Pro Ala Val Glu Phe Leu Arg Gln Ile
                245                 250

<210> 26
<211> 164
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 26
Met Lys Lys Arg Leu Ser Trp Ile Ser Val Cys Leu Leu Val Leu Val
 1               5                  10                  15
Ser Ala Ala Gly Met Leu Phe Ser Thr Ala Ala Lys Thr Glu Thr Ser
            20                  25                  30
Ser His Lys Ala His Thr Glu Ala Gln Val Ile Asn Thr Phe Asp Gly
        35                  40                  45
Val Ala Asp Tyr Leu Gln Thr Tyr His Lys Leu Pro Asp Asn Tyr Ile
    50                  55                  60
Thr Lys Ser Glu Ala Gln Ala Leu Gly Trp Val Ala Ser Lys Gly Asn
65                  70                  75                  80
Leu Ala Asp Val Ala Pro Gly Lys Ser Ile Gly Gly Asp Ile Phe Ser
                85                  90                  95
Asn Arg Glu Gly Lys Leu Pro Gly Lys Ser Gly Arg Thr Trp Arg Glu
            100                 105                 110
Ala Asp Ile Asn Tyr Thr Ser Gly Phe Arg Asn Ser Asp Arg Ile Leu
        115                 120                 125
Tyr Ser Ser Asp Trp Leu Ile Tyr Lys Thr Thr Asp His Tyr Gln Thr
    130                 135                 140
Phe Thr Lys Ile Arg Ala Ala Asn Asp Glu Asn Tyr Ser Glu Asn Tyr
145                 150                 155                 160
Ala Asp Ala Ser


<210> 27
<211> 195
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 27
Met Thr His Gly Pro Lys Asp Ser Met Val Arg Ser Glu Gly Lys His
 1               5                  10                  15
Ser Ile Ser Ser His Glu Met Asn Ser Ser Lys Tyr Val Glu Ser Pro
            20                  25                  30
Asn Tyr Thr Lys Val Glu Phe Gly Glu His Tyr Ala Arg Leu Arg Pro
        35                  40                  45
Lys Lys Leu Lys Ala Asn Ile Glu Tyr Thr Thr Pro Thr Gly His Ile
    50                  55                  60
Tyr Arg Thr Asp His Lys Gly Arg Ile Lys Glu Val Tyr Val Asp Asn
65                  70                  75                  80
Leu Ser Leu Lys Asp Gly Asp Arg Asn Ser His Ala Gln Arg Thr Val
                85                  90                  95
Gly Gly Glu Asp Arg Leu Pro Asp Asp Asp Gly Gly His Leu Ile Ala
            100                 105                 110
Arg Met Phe Gly Gly Ser Lys Asp Ile Asp Asn Leu Val Ala Gln Ser
        115                 120                 125
Lys Phe Ile Asn Arg Pro Phe Lys Glu Lys Gly His Trp Tyr Asn Leu
    130                 135                 140
Glu Lys Glu Trp Gln Glu Phe Leu Asn Ser Gly Lys Glu Val Lys Asn
145                 150                 155                 160
Ile Lys Met Glu Val Lys Tyr Ser Gly Asn Ser Gln Arg Pro Thr Ile
                165                 170                 175
Phe Lys Val Glu Tyr Glu Ile Asn Gly Glu Arg Asn Ile Arg Arg Ile
            180                 185                 190
Leu Asn Lys
        195

<210> 28
<211> 195
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 28
Met Thr His Gly Pro Lys Asp Ser Met Val Arg Ser Glu Gly Lys His
 1               5                  10                  15
Ser Ile Ser Ser His Glu Met Asn Ser Ser Lys Tyr Val Glu Ser Pro
            20                  25                  30
Asn Tyr Thr Lys Val Glu Phe Gly Glu His Tyr Ala Arg Leu Arg Pro
        35                  40                  45
Lys Lys Leu Lys Ala Asn Ile Glu Tyr Thr Thr Pro Thr Gly His Ile
    50                  55                  60
Tyr Arg Thr Asp His Lys Gly Arg Ile Lys Glu Val Tyr Val Asp Asn
65                  70                  75                  80
Leu Ser Leu Lys Asp Gly Asp Arg Asn Ser His Ala Gln Arg Thr Val
                85                  90                  95
Gly Gly Glu Asp Arg Leu Pro Asp Asp Asp Gly Gly His Leu Ile Ala
            100                 105                 110
Arg Met Phe Gly Gly Ser Lys Asp Ile Asp Asn Leu Val Ala Gln Ser
        115                 120                 125
Lys Phe Ile Asn Arg Pro Phe Lys Glu Lys Gly His Trp Tyr Asn Leu
    130                 135                 140
Glu Lys Glu Trp Gln Glu Phe Leu Asn Ser Gly Lys Glu Val Lys Asn
145                 150                 155                 160
Ile Lys Met Glu Tyr Lys Tyr Ser Gly Asn Ser Gln Arg Pro Thr Ile
                165                 170                 175
Phe Lys Val Glu Tyr Glu Ile Asn Gly Glu Arg Asn Ile Arg Arg Ile
            180                 185                 190
Leu Asn Lys
        195

<210> 29
<211> 271
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 29
Met Ser Phe Asp Pro Phe Gly Asp Phe Glu Thr Thr Gly Tyr Leu Arg
 1               5                  10                  15
Asn Ser Leu Gly Leu Lys Asp Pro Ala Glu Val Lys Glu Asn Glu His
            20                  25                  30
Phe Ser Phe Glu Met Gly Leu Asp Glu Ala Leu Ser Tyr Leu Glu Arg
        35                  40                  45
Thr Lys Asn Leu Asn Tyr Gln Ala Leu Leu Gln Val His Arg Leu Leu
    50                  55                  60
Phe Glu Lys Phe Tyr Pro Trp Ala Gly Arg Asp Arg Leu Glu Leu Val
65                  70                  75                  80
Pro His Leu Ser Val Trp Lys Gly Pro Lys Gly Ala Pro Arg Arg Thr
                85                  90                  95
Phe Phe Glu Ser Pro Ala Met Ile Glu Arg Ala Val Asp Tyr Ala Leu
            100                 105                 110
Ser Leu Ala Ser Lys Lys Gln Gly Phe Met Gln Lys Pro Gly Glu Val
        115                 120                 125
Met Gly Leu Leu Cys Phe Ala His Pro Phe Leu Asp Gly Asn Gly Arg
    130                 135                 140
Ser Ile Leu Leu Phe Tyr Met Glu Leu Ser Tyr Arg Ala Gly Phe Ala
145                 150                 155                 160
Ile Asp Trp Ala Ser Thr Arg Lys Asp Asp Tyr Leu Gln Ala Leu Asp
                165                 170                 175
Asp Glu Ile His Asn Pro Gly Lys Gly His Leu Asp Arg Tyr Leu Val
            180                 185                 190
Pro Phe Val Val Pro Ile His Ser Arg Asp Gln Trp Pro Glu Ile Ile
        195                 200                 205
Gly Gln Ile Asn Gly Leu Asp Gly Met Asp Gly Glu Asn Ile Thr Tyr
    210                 215                 220
Glu Asn Leu Asp Asp Pro Glu Val Gln Lys Val Tyr Ala Ala Tyr His
225                 230                 235                 240
Ala Glu His Pro Tyr Pro Ala Lys Asp Gly Thr Pro Asp Ser Glu Pro
                245                 250                 255
Ala Ala Asn Asp Glu Asn Tyr Ser Glu Asn Tyr Ala Asp Ala Ser
            260                 265                 270
