                         SEQUENCE LISTING

<110>  NoNO INC.
       TYMIANSKI, MICHAEL
       GARMAN, JONATHAN D.
       MAYOR, DIANA
 
<120>  PLASMIN-RESISTANT PEPTIDES FOR TREATING STROKE AND RELATED 
       CONDITIONS

<130>  057769-695323

<150>  US 62/959,091
<151>  2020-01-09

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  1

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  2
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  2

Lys Leu Ser Ser Ile Glu Ser Asp Val 
1               5                   


<210>  3
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Glu, Asp, Asn, or Gln

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Asp, Glu, Gln, or Asn

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Val or Leu

<400>  3

Xaa Xaa Xaa Xaa 
1               


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Thr

<400>  4

Ile Glu Xaa Asp Val 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  5

Ile Glu Ser Asp Val 
1               5   


<210>  6
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  D-amino acids

<400>  6

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  7
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  D-amino acids

<400>  7

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Ser Ser Ile Glu 
1               5                   10                  15      


Ser Asp Val 
            


<210>  8
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  D-amino acids

<400>  8

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Ser Ile Glu Ser 
1               5                   10                  15      


Asp Val 
        


<210>  9
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  D-amino acids

<400>  9

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Ile Glu Ser Asp 
1               5                   10                  15      


Val 
    


<210>  10
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu, Asp, Asn, or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asp, Glu, Gln, or Asn

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Val or Leu

<400>  10

Ile Xaa Xaa Xaa Xaa 
1               5   


<210>  11
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  11

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  12

Lys Leu Ser Ser Ile Glu Thr Asp Val 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  13

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  14

Glu Ser Asp Val 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  15

Glu Ser Glu Val 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  16

Glu Thr Asp Val 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  17

Glu Thr Ala Val 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  18

Glu Thr Glu Val 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  19

Asp Thr Asp Val 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  20

Asp Thr Glu Val 
1               


<210>  21
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  21

Ile Glu Ser Glu Val 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  22

Ile Glu Thr Asp Val 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  23

Ile Glu Thr Ala Val 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  24

Ile Glu Thr Glu Val 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  25

Ile Asp Thr Asp Val 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  26

Ile Asp Thr Glu Val 
1               5   


<210>  27
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Glu, Gln, Ala, or an analog thereof

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ala, Gln, Asp, Asn, N-Me-Ala, N-Me-Gln, N-Me-Asp, 
       N-Me-Asn, or an analog thereof

<400>  27

Xaa Xaa Xaa Val 
1               


<210>  28
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu, Gln, Ala, or an analog thereof

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Thr or Ser

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ala, Gln, Asp, Asn, N-Me-Ala, N-Me-Gln, N-Me-Asp, 
       N-Me-Asn, or an analog thereof

<400>  28

Ile Xaa Xaa Xaa Val 
1               5   


<210>  29
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  29

Arg Leu Ser Gly Met Asn Glu Val Leu Ser Phe Arg Trp Leu 
1               5                   10                  


<210>  30
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  30

Gly Ser Ser Ser Ser 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  31

Thr Gly Glu Lys Pro 
1               5   


<210>  32
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  32

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  33
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  33

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  34
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  34

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10              


<210>  35
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  35

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  36
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  36

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is an amino acid other than Tyr

<400>  37

Xaa Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  38

Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  39
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  39

Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly 
1               5                   10  


<210>  40
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  40

Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly Tyr 
1               5                   10      


<210>  41
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  41

Gly Lys Lys Lys Lys Lys Gln Lys Lys Lys 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  42

Gly Ala Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  43
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  43

Ala Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  44
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  44

Gly Arg Lys Ala Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  45
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  45

Arg Lys Ala Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  46

Gly Arg Lys Lys Ala Arg Gln Arg Arg Arg 
1               5                   10  


<210>  47
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  47

Arg Lys Lys Ala Arg Gln Arg Arg Arg 
1               5                   


<210>  48
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  48

Gly Arg Lys Lys Arg Arg Gln Ala Arg Arg 
1               5                   10  


<210>  49
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  49

Arg Lys Lys Arg Arg Gln Ala Arg Arg 
1               5                   


<210>  50
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  50

Gly Arg Lys Lys Arg Arg Gln Arg Ala Arg 
1               5                   10  


<210>  51
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  51

Arg Lys Lys Arg Arg Gln Arg Ala Arg 
1               5                   


<210>  52
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  52

Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  53

Arg Arg Ala Arg Arg Ala Arg Arg Ala Arg Arg 
1               5                   10      


<210>  54
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  54

Arg Arg Arg Ala Arg Arg Arg Ala Arg Arg 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  55

Arg Arg Arg Pro Arg Arg Arg Pro Arg Arg 
1               5                   10  


<210>  56
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  56

Arg Arg Pro Arg Arg Pro Arg Arg 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  57

Arg Arg Ala Arg Arg Ala Arg Arg 
1               5               


<210>  58
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  58

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  D-amino acids

<400>  59

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  60
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  D-amino acids

<400>  60

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  61
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  D-amino acids

<400>  61

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  62
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  D-amino acids

<400>  62

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Thr Asp Val 
            20  


<210>  63
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  D-amino acids

<400>  63

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Thr Asp Val 
            20  


<210>  64
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  D-amino acids

<400>  64

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Thr Asp Val 
            20  


<210>  65
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  D-amino acids

<400>  65

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Ser Ser Ile Glu 
1               5                   10                  15      


Thr Asp Val 
            


<210>  66
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  D-amino acids

<400>  66

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Ser Ile Glu Thr 
1               5                   10                  15      


Asp Val 
        


<210>  67
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  D-amino acids

<400>  67

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Ile Glu Thr Asp 
1               5                   10                  15      


Val 
    


<210>  68
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  D-amino acids

<400>  68

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Ile Glu Ser Asp Val 
1               5                   10                  15      


<210>  69
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  D-amino acids

<400>  69

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Ile Glu Thr Asp Val 
1               5                   10                  15      


<210>  70
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<400>  70

Lys Leu Ser Ser Ile Glu Ser Asp Val 
1               5                   


<210>  71
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<400>  71

Leu Ser Ser Ile Glu Ser Asp Val 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  72

Leu Ser Ser Ile Glu Ser Asp Val 
1               5               


<210>  73
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  73

Ser Ser Ile Glu Ser Asp Val 
1               5           


<210>  74
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  74

Ser Ile Glu Ser Asp Val 
1               5       


<210>  75
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  D-amino acids

<400>  75

Lys Leu Ser Ser Ile Glu Thr Asp Val 
1               5                   


<210>  76
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-amino acid

<400>  76

Leu Ser Ser Ile Glu Thr Asp Val 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  77

Leu Ser Ser Ile Glu Thr Asp Val 
1               5               


<210>  78
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  78

Ser Ser Ile Glu Thr Asp Val 
1               5           


<210>  79
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  79

Ser Ile Glu Thr Asp Val 
1               5       


<210>  80
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  D-amino acids

<400>  80

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  81
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  D-amino acids

<400>  81

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  82
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  82

Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile Glu Ser Asp Val 
1               5                   10                  15  


<210>  83
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  83

Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile Glu Ser Asp Val 
1               5                   10                  


<210>  84
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  84

Gln Arg Arg Arg Lys Leu Ser Ser Ile Glu Ser Asp Val 
1               5                   10              


<210>  85
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  85

Arg Arg Lys Leu Ser Ser Ile Glu Ser Asp Val 
1               5                   10      


<210>  86
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  86

Arg Lys Leu Ser Ser Ile Glu Ser Asp Val 
1               5                   10  


<210>  87
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  87

Leu Ser Ser Ile Glu Ser Asp Val 
1               5               


