                         SEQUENCE LISTING

<110>  INSERM
 
<120>  Rspo1 proteins and their use

<130>  EB19175 COLLOMBAT

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      


Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          


Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              


Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys 
    50                  55                  60                  


Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys 
65                  70                  75                  80  


Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys 
                85                  90                  95      


Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser 
            100                 105                 110 


<210>  2
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val 
1               5                   10                  15      


Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg 
            20                  25                  30          


Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly 
        35                  40                  45              


Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys 
    50                  55                  60                  


Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys 
65                  70                  75                  80  


Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro 
                85                  90                  95      


Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro Ala 
            100                 105                 110         


Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys Lys 
        115                 120                 125             


Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg Arg 
    130                 135                 140                 


Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr Lys 
145                 150                 155                 160 


Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro 
                165                 170             


<210>  3
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      


Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          


Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              


Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys 
    50                  55                  60                  


Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys 
65                  70                  75                  80  


Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys 
                85                  90                  95      


Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro 
            100                 105                 110         


Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys 
        115                 120                 125             


Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg 
    130                 135                 140                 


Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr 
145                 150                 155                 160 


Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu Gly 
                165                 170                 175     


Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn Arg 
            180                 185                 190         


Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg Arg 
        195                 200                 205             


Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro Leu 
    210                 215                 220                 


Thr Ser Ala Gly Pro Ala 
225                 230 


<210>  4
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 


Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 


Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr 
                165                 170                 175     


Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp 
            180                 185                 190         


Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu 
        195                 200                 205             


Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn 
    210                 215                 220                 


Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg 
225                 230                 235                 240 


Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val Gly Pro 
                245                 250                 255     


Leu Thr Ser Ala Gly Pro Ala 
            260             


<210>  5
<211>  3058
<212>  DNA
<213>  Homo sapiens

<400>  5
ccctctccgg gctgggagct ccggccgagc ggaggcgcga cggagagcac cagcgcaggg       60

cagagagccc ggagcgaccg gccagagtag ggcatccgct cgggtgctgc ggagaacgag      120

ggcagctccg agccgccccg gaggaccgat gcgccgggtg gggcgctggc cccgagggcg      180

tgagccgtcc gcagattgag caacttggga acgggcgggc ggagcgcagg cgagccgggc      240

gcccaggaca gtcccgcagc gggcgggtga gcgggccgcg ccctcgcccc tcccgggcct      300

gcccccgtcg cgactggcag cacgaagctg agattgtggt ttcctggtga ttcaggtggg      360

agtgggccag aagatcaccg ctggcaagga ctggtgtttg tcaactgtaa ggactcatgg      420

aacagatcta ccagggattc tcagacctta gtttgagaaa tgctgcaatt aaaggcaaat      480

cctatcactc tgagtgatcg ctttggtgtc gaggcaatca accataaaga taaatgcaaa      540

tatggaaatt gcataacagt actcagtatt aaggttggtt tttggagtag tccctgctga      600

cgtgacaaaa agatctctca tatgatattc cgaggtatct ttgaggaagt ctctctttga      660

ggacctccct ttgagctgat ggagaactgg gctccccaca ccctctctgt ccccagctga      720

gattatggtg gatttgggct acggcccagg cctgggcctc ctgctgctga cccagcccca      780

gaggtgttag caagagccgt gtgctatcca ccctccccga gaccacccct ccgaccaggg      840

gcctggagct ggcgcgtgac tatgcggctt gggctgtgtg tggtggccct ggttctgagc      900

tggacgcacc tcaccatcag cagccggggg atcaagggga aaaggcagag gcggatcagt      960

gccgagggga gccaggcctg tgccaaaggc tgtgagctct gctctgaagt caacggctgc     1020

ctcaagtgct cacccaagct gttcatcctg ctggagagga acgacatccg ccaggtgggc     1080

gtctgcttgc cgtcctgccc acctggatac ttcgacgccc gcaaccccga catgaacaag     1140

tgcatcaaat gcaagatcga gcactgtgag gcctgcttca gccataactt ctgcaccaag     1200

tgtaaggagg gcttgtacct gcacaagggc cgctgctatc cagcttgtcc cgagggctcc     1260

tcagctgcca atggcaccat ggagtgcagt agtcctgcgc aatgtgaaat gagcgagtgg     1320

tctccgtggg ggccctgctc caagaagcag cagctctgtg gtttccggag gggctccgag     1380

gagcggacac gcagggtgct acatgcccct gtgggggacc atgctgcctg ctctgacacc     1440

aaggagaccc ggaggtgcac agtgaggaga gtgccgtgtc ctgaggggca gaagaggagg     1500

aagggaggcc agggccggcg ggagaatgcc aacaggaacc tggccaggaa ggagagcaag     1560

gaggcgggtg ctggctctcg aagacgcaag gggcagcaac agcagcagca gcaagggaca     1620

gtggggccac tcacatctgc agggcctgcc tagggacact gtccagcctc caggcccatg     1680

cagaaagagt tcagtgctac tctgcgtgat tcaagctttc ctgaactgga acgtcggggg     1740

caaagcatac acacacactc caatccatcc atgcatacat agacacaaga cacacacgct     1800

caaacccctg tccacatata caaccataca tacttgcaca tgtgtgttca tgtacacacg     1860

cagacacaga caccacacac acacatacac acacacacac acacacacct gaggccacca     1920

gaagacactt ccatccctcg ggcccagcag tacacacttg gtttccagag ctcccagtgg     1980

acatgtcaga gacaacactt cccagcatct gagaccaaac tgcagagggg agccttctgg     2040

agaagctgct gggatcggac cagccactgt ggcagatggg agccaagctt gaggactgct     2100

ggtgacctgg gaagaaacct tcttcccatc ctgttcagca ctcccagctg tgtgacttta     2160

tcgttggaga gtattgttac ccttccagga tacatatcag ggttaacctg actttgaaaa     2220

ctgcttaaag gtttatttca aattaaaaca aaaaaatcaa cgacagcagt agacacaggc     2280

accacattcc tttgcagggt gtgagggttt ggcgaggtat gcgtaggagc aagaagggac     2340

agggaatttc aagagacccc aaatagcctg ctcagtagag ggtcatgcag acaaggaaga     2400

aaacttaggg gctgctctga cggtggtaaa caggctgtct atatccttgt tactcagagc     2460

atggcccggc agcagtgttg tcacagggca gcttgttagg aatgagaatc tcaggtctca     2520

ttccagacct ggtgagccag agtctaaatt ttaagattcc tgatgattgg catgttaccc     2580

aaatttgaga agtgctgctg taattcccct taaaggacgg gagaaagggc cccggccatc     2640

ttgcagcagg agggattctg gtcagctata aaggaggact ttccatctgg gagaggcaga     2700

atctatatac tgaagggcta gtggcactgc caggggaagg gagtgcgtag gcttccagtg     2760

atggttgggg acaatcctgc ccaaaggcag ggcagtggat ggaataactc cttgtggcat     2820

tctgaagtgt gtgccaggct ctggactagg tgctaggttt ccagggagga gccaaacacg     2880

ggccttgctc ttgtggagct tagaggttgg tggggaagaa aataggcatg caccaaggaa     2940

ttgtacaaac acatatataa ctacaaaagg atggtgccaa gggcaggtga ccactggcat     3000

ctatgcttag ctatgaaagt gaataaagca gaataaaaat aaaatacttt ctctcagg       3058


<210>  6
<211>  265
<212>  PRT
<213>  Mus musculus

<400>  6

Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      


Ile Ala Val Gly Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          


Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              


Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  


Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  


Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      


Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         


Lys Cys Gln Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             


Cys Pro Glu Gly Ser Thr Ala Ala Asn Ser Thr Met Glu Cys Gly Ser 
    130                 135                 140                 


Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 


Lys Lys Arg Lys Leu Cys Gly Phe Arg Lys Gly Ser Glu Glu Arg Thr 
                165                 170                 175     


Arg Arg Val Leu His Ala Pro Gly Gly Asp His Thr Thr Cys Ser Asp 
            180                 185                 190         


Thr Lys Glu Thr Arg Lys Cys Thr Val Arg Arg Thr Pro Cys Pro Glu 
        195                 200                 205             


Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn 
    210                 215                 220                 


Arg His Pro Ala Arg Lys Asn Ser Lys Glu Pro Gly Ser Asn Ser Arg 
225                 230                 235                 240 


Arg His Lys Gly Gln Gln Gln Pro Gln Pro Gly Thr Thr Gly Pro Leu 
                245                 250                 255     


Thr Ser Val Gly Pro Thr Trp Ala Gln 
            260                 265 


<210>  7
<211>  1834
<212>  DNA
<213>  Mus musculus

<400>  7
ggattccctc cctcgtgcga gccggggacc ggcccctctc cgggcgcggg gcgcagagcc       60

cgggcggcgc actgcggggc ccgcgcgggc cgccccagca ccaatgcacc gggcggggcg      120

ctggcggccg agaaggcatt gagcaactgg gcggcgggcg gagcgcgggg ccgacggcaa      180

cgcgggaccc agtggccgcg ccctcgcccc tccgggctgc cccgccacgg ccgctgcgcc      240

aggtctatct tgggggtggt tctctgctgg cgtgagaaga cttctcatgt gaccctctga      300

ggtggattca agcaggacag gacctccctt tggaccaatg gagaagccgg ctccaaaccc      360

tctcggatcc cagctaaggt tatggtggat ccgggcctgg ctctcctgcc actgacccag      420

cctcagagcc ttttagcaag agaccacccc tcctgccagg ggcccggggc tggccagtga      480

ctatgcggct tgggctgtgc gtggtggccc tggttctgag ctggacacac atcgccgtgg      540

gcagccgggg gatcaagggc aagagacaga ggcggatcag tgctgagggg agccaagcct      600

gcgccaaggg ctgtgagctc tgttcagaag tcaacggttg cctcaagtgc tcgcccaagc      660

tcttcattct gctggagagg aacgacatcc gccaggtggg cgtctgcctg ccgtcctgcc      720

cacctggata ctttgatgcc cgcaaccccg acatgaacaa atgcatcaaa tgcaagatcg      780

agcactgtga ggcctgcttc agccacaact tctgcaccaa gtgtcaggag ggcttgtact      840

tacacaaggg ccgctgctat ccagcctgcc ctgagggctc tacagccgct aacagcacca      900

tggagtgcgg cagtcctgca caatgtgaaa tgagcgagtg gtccccgtgg ggaccctgct      960

ccaagaagag gaagctgtgc ggtttccgga agggatcgga agagcggaca cgcagagtgc     1020

tccatgctcc cgggggagac cacaccacct gctccgacac caaagagacc cgcaagtgta     1080

ccgtgcgcag gacgccctgc ccagaggggc agaagaggag gaaggggggc cagggccgga     1140

gggagaatgc caacaggcat ccggccagga agaacagcaa ggagccgggc tccaactctc     1200

ggagacacaa agggcaacag cagccacagc cagggacaac agggccactc acatcagtag     1260

gacctacctg ggcacagtga ccggtctcca gatacctgtg gaagagtaca gtgctgtact     1320

gtataatgag aactttccag aactggagca tctgggagag tccacacata ccccatccac     1380

ccacccatcc aactatccat ccatccatcc atgcacacat atggccacat ctgaaaacgt     1440

caacacacac acacacacac acacacacac acacacacat tcttgaggtc actgaagaca     1500

cttctattct gtggcccagc tgtatattca gtctttaatg ctcttggaag acatatctga     1560

gagaaccttt cccagcatct gaaactaagg agtggaacct tctggaggaa cttctgggac     1620

agcatctgac agatggatgg cagattggag ccaaagctgg agcagctgcc gagagggaga     1680

gagagggaaa gcgctttccc ggcttgagag gcactcccag ctgtgagact tgattgtcgg     1740

agatgagaat tattacacat ccgtggtaca cgtcacggat gacctgactt ggaaactgct     1800

taaaggttta tttcaaatta aaaaagagaa aaac                                 1834


<210>  8
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Lys Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe 
1               5                   10                  15      


Cys Thr Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr 
            20                  25                  30          


Pro Ala Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys 
        35                  40                  45              


Ser Ser Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro 
    50                  55                  60                  


Cys Ser Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu 
65                  70                  75                  80  


Arg Thr Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys 
                85                  90                  95      


Ser Asp Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys 
            100                 105                 110         


Pro 
    


<210>  9
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Lys Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe 
1               5                   10                  15      


Cys Thr Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr 
            20                  25                  30          


Pro Ala Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys 
        35                  40                  45              


Ser Ser Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro 
    50                  55                  60                  


Cys Ser Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu 
65                  70                  75                  80  


Arg Thr Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys 
                85                  90                  95      


Ser Asp Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys 
            100                 105                 110         


Pro Glu Gly Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn 
        115                 120                 125             


Ala Asn Arg Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly 
    130                 135                 140                 


Ser Arg Arg Arg Lys Gly Gln Gln Gln Gln Gln Gln Gln Gly Thr Val 
145                 150                 155                 160 


Gly Pro Leu Thr Ser Ala Gly Pro Ala 
                165                 


<210>  10
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      


Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          


Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              


Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys 
    50                  55                  60                  


Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys 
65                  70                  75                  80  


Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys 
                85                  90                  95      


Pro Glu Gly Ser Ser Ala 
            100         


<210>  11
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val Asn Gly Cys Leu 
1               5                   10                  15      


Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg Asn Asp Ile Arg 
            20                  25                  30          


Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly Tyr Phe Asp Ala 
        35                  40                  45              


Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys 
    50                  55                  60                  


Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu 
65                  70                  75                  80  


Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly 
                85                  90                  


<210>  12
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      


Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          


Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              


Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys 
    50                  55                  60                  


Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys 
65                  70                  75                  80  


Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys 
                85                  90                  95      


Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser 
            100                 105                 110 


<210>  13
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      


Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          


Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              


Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile 
    50                  55                  60          


<210>  14
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      


Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          


Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              


Gly Tyr Phe Asp 
    50          


<210>  15
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val Asn Gly Cys Leu 
1               5                   10                  15      


Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg Asn Asp Ile Arg 
            20                  25                  30          


Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly Tyr Phe Asp Ala 
        35                  40                  45              


<210>  16
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Lys Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe 
1               5                   10                  15      


Cys Thr Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr 
            20                  25                  30          


Pro Ala Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys 
        35                  40                  45              


Ser 
    


<210>  17
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  17

Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser 
1               5                   10                  15      


His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly 
            20                  25                  30          


Arg Cys Tyr Pro Ala Cys Pro Glu Gly 
        35                  40      


<210>  18
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys Glu Ala Cys Phe 
1               5                   10                  15      


Ser His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu Tyr Leu His Lys 
            20                  25                  30          


Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly Ser Ser Ala 
        35                  40                  45  


<210>  19
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      


Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          


Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              


Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys 
    50                  55                  60                  


Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys 
65                  70                  75                  80  


Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys 
                85                  90                  95      


Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro 
            100                 105                 110         


Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys 
        115                 120                 125             


Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg 
    130                 135                 140                 


Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr 
145                 150                 155                 160 


Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys 
                165                 170             


<210>  20
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val Asn Gly Cys Leu 
1               5                   10                  15      


Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg Asn Asp Ile Arg 
            20                  25                  30          


Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly Tyr Phe Asp Ala 
        35                  40                  45              


Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys 
    50                  55                  60                  


Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu 
65                  70                  75                  80  


Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly Ser Ser 
                85                  90                  95      


Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro Ala Gln Cys Glu Met 
            100                 105                 110         


Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys Lys Gln Gln Leu Cys 
        115                 120                 125             


Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg Arg Val Leu His Ala 
    130                 135                 140                 


Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr Lys Glu Thr Arg Arg 
145                 150                 155                 160 


Cys Thr Val Arg Arg Val Pro Cys 
                165             


<210>  21
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val Asn Gly Cys Leu 
1               5                   10                  15      


Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg Asn Asp Ile Arg 
            20                  25                  30          


Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly Tyr Phe Asp Ala 
        35                  40                  45              


Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys 
    50                  55                  60                  


Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu 
65                  70                  75                  80  


Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly Ser Ser 
                85                  90                  95      


Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro Ala Gln Cys Glu Met 
            100                 105                 110         


Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys Lys Gln Gln Leu Cys 
        115                 120                 125             


Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg Arg Val Leu His Ala 
    130                 135                 140                 


Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr Lys Glu Thr Arg Arg 
145                 150                 155                 160 


Cys Thr Val Arg Arg Val Pro Cys Pro 
                165                 


<210>  22
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      


Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          


Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              


Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys 
    50                  55                  60                  


Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys 
65                  70                  75                  80  


Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys 
                85                  90                  95      


Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro 
            100                 105                 110         


Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys 
        115                 120                 125             


Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg 
    130                 135                 140                 


Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr 
145                 150                 155                 160 


Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu Gly 
                165                 170                 175     


Gln Lys Arg Arg Lys Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn Arg 
            180                 185                 190         


Asn Leu Ala Arg Lys Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg Arg 
        195                 200                 205             


Arg Lys Gly Gln Gln Gln Gln Gln 
    210                 215     


<210>  23
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val Asn Gly Cys Leu 
1               5                   10                  15      


Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg Asn Asp Ile Arg 
            20                  25                  30          


Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly Tyr Phe Asp Ala 
        35                  40                  45              


Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys 
    50                  55                  60                  


Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu 
65                  70                  75                  80  


Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly Ser Ser 
                85                  90                  95      


Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro Ala Gln Cys Glu Met 
            100                 105                 110         


Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys Lys Gln Gln Leu Cys 
        115                 120                 125             


Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg Arg Val Leu His Ala 
    130                 135                 140                 


Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr Lys Glu Thr Arg Arg 
145                 150                 155                 160 


Cys Thr Val Arg Arg Val Pro Cys Pro Glu Gly Gln Lys Arg Arg Lys 
                165                 170                 175     


Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn Arg Asn Leu Ala Arg Lys 
            180                 185                 190         


Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg Arg Arg Lys Gly Gln Gln 
        195                 200                 205             


Gln Gln Gln Gln Gln Gly Thr Val Gly Pro Leu Thr Ser Ala Gly Pro 
    210                 215                 220                 


Ala 
225 


<210>  24
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu Val Asn Gly Cys Leu 
1               5                   10                  15      


Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu Arg Asn Asp Ile Arg 
            20                  25                  30          


Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro Gly Tyr Phe Asp Ala 
        35                  40                  45              


Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys 
    50                  55                  60                  


Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu 
65                  70                  75                  80  


Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly Ser Ser 
                85                  90                  95      


Ala Ala Asn Gly Thr Met Glu Cys Ser Ser Pro Ala Gln Cys Glu Met 
            100                 105                 110         


Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser Lys Lys Gln Gln Leu Cys 
        115                 120                 125             


Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr Arg Arg Val Leu His Ala 
    130                 135                 140                 


Pro Val Gly Asp His Ala Ala Cys Ser Asp Thr Lys Glu Thr Arg Arg 
145                 150                 155                 160 


Cys Thr Val Arg Arg Val Pro Cys Pro Glu Gly Gln Lys Arg Arg Lys 
                165                 170                 175     


Gly Gly Gln Gly Arg Arg Glu Asn Ala Asn Arg Asn Leu Ala Arg Lys 
            180                 185                 190         


Glu Ser Lys Glu Ala Gly Ala Gly Ser Arg Arg Arg Lys Gly Gln Gln 
        195                 200                 205             


Gln Gln Gln 
    210     


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  25

Gly Gly Gly Gly Ser 
1               5   


