﻿                         序列表

<110>  SHANGHAI HENLIUS BIOTECH, INC.

<120>  ANTI-TIGIT ANTIBODIES, MULTISPECIFIC ANTIBODIES COMPRISING THE SAME AND METHODS OF USING THE SAME

<130>  SH1903-20P450257

<150>  PCT/CN2020/071336
<151>  2020-01-10

<160>  262

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4A11 CDR1


<400>  1
Gly Arg Pro Phe Ser Asn Tyr Thr 
1               5               

<210>  2
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  4A11 CDR2


<400>  2
Ala Trp Pro Ser Pro Ser Thr 
1               5           

<210>  3
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  4A11 CDR3


<400>  3
Ala Ala Asp Tyr Lys Ser Leu Thr Gln Ser Trp Leu Asn Ala Ala Leu 
1               5                   10                  15      
Asp Tyr 
        

<210>  4
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  4A11 VHH


<400>  4
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Glu Ala Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Gly Leu Ala Trp Pro Ser Pro Ser Thr Tyr Val Val Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Asp Tyr Lys Ser Leu Thr Gln Ser Trp Leu Asn Ala Ala Leu Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  5
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4B5 CDR1


<400>  5
Pro Arg Thr Phe Ser Thr Phe His 
1               5               

<210>  6
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4B5 CDR2


<400>  6
Phe Asn Trp Ser Gly Gly Arg Thr 
1               5               

<210>  7
<211>  26
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(26)
<223>  4B5 CDR3


<400>  7
Ala Ala Ala Arg Asp Arg Gly Leu His Asp Gly Thr Thr Ser Asp Ser 
1               5                   10                  15      
Tyr Leu Glu Gly Ser His Glu Tyr Glu Tyr 
            20                  25      

<210>  8
<211>  133
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(133)
<223>  4B5 VHH


<400>  8
Gln Val Lys Leu Glu Glu Ser Gly Gly Arg Ser Val Leu Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Arg Cys Ala Gly Thr Pro Arg Thr Phe Ser Thr Phe 
            20                  25                  30          
His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Phe Asn Trp Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Gly Lys Asn Met Val Tyr 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Thr Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ala Arg Asp Arg Gly Leu His Asp Gly Thr Thr Ser Asp Ser 
            100                 105                 110         
Tyr Leu Glu Gly Ser His Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Gln 
        115                 120                 125             
Val Thr Val Ser Ser 
    130             

<210>  9
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4C5 CDR1


<400>  9
Gly Arg Ser Val Ser Thr Tyr Phe 
1               5               

<210>  10
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4C5 CDR2


<400>  10
Ile Asp Arg Gly Ser Thr Val Thr 
1               5               

<210>  11
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(17)
<223>  4C5 CDR3


<400>  11
Ala Ala Lys Ala Ile Thr Arg Asn Phe Ile Ala Thr Asn Asp Tyr Asp 
1               5                   10                  15      
Tyr 
    

<210>  12
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  4C5 VHH


<400>  12
Gln Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Ser Val Ser Thr Tyr 
            20                  25                  30          
Phe Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asp Arg Gly Ser Thr Val Thr Arg Tyr Asp Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Ala Ile Thr Arg Asn Phe Ile Ala Thr Asn Asp Tyr Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  13
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4D5 CDR1


<400>  13
Gly Arg Ala Phe Asn Glu Tyr Ala 
1               5               

<210>  14
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4D5 CDR2


<400>  14
Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  15
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  4D5 CDR3


<400>  15
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  16
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  4D5 VHH


<400>  16
Val Asp Ser Gly Gly Gly Ala Val Lys Ala Gly Asp Ser Leu Arg Leu 
1               5                   10                  15      
Val Cys Ser Ala Pro Gly Arg Thr His Gly Arg Ala Phe Asn Glu Tyr 
            20                  25                  30          
Ala Met Ala Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 

<210>  17
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4D11 CDR1


<400>  17
Gly Ser Ile Ser Ser Ile Asn Ala 
1               5               

<210>  18
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  4D11 CDR2


<400>  18
Ile Thr Asn Ser Gly Ser Thr 
1               5           

<210>  19
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  4D11 CDR3


<400>  19
Thr Ala Arg Arg Ser Thr Trp Tyr Ile Ser 
1               5                   10  

<210>  20
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  4D11 VHH


<400>  20
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Ala Met Gly Trp Tyr Arg Leu Ala Pro Gly Lys His Arg Glu Phe Val 
        35                  40                  45              
Ala Asp Ile Thr Asn Ser Gly Ser Thr Asn Tyr Ala Ala Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Asn Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      
Ala Arg Arg Ser Thr Trp Tyr Ile Ser Ser Gly Arg Gly Thr Gln Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  21
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4E5 CDR1


<400>  21
Gly Leu Thr Ser Ser Asp Ile Ala 
1               5               

<210>  22
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4E5 CDR2


<400>  22
Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  23
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  4E5 CDR3


<400>  23
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  24
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  4E5 VHH


<400>  24
Gln Val Gln Leu Val Asp Ser Gly Gly Gly Val Val Glu Val Gly Ala 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Glu Thr Ser Gly Leu Thr Ser Ser Asp Ile 
            20                  25                  30          
Ala Val Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 

<210>  25
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4H6 CDR1


<400>  25
Gly Thr Ile Phe Arg Leu Asn Arg 
1               5               

<210>  26
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4H6 CDR2


<400>  26
Thr Ile Trp Ser Gly Arg Arg Thr 
1               5               

<210>  27
<211>  14
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(14)
<223>  4H6 CDR3


<400>  27
Asn Tyr Arg Arg Ile Thr Pro Trp Glu Ala Ser Gly Asn Tyr 
1               5                   10                  

<210>  28
<211>  121
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(121)
<223>  4H6 VHH


<400>  28
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Thr Ala Gly Ala 
1               5                   10                  15      
Ser Leu Ile Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Arg Leu Asn 
            20                  25                  30          
Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              
Ala Ala Thr Ile Trp Ser Gly Arg Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  
Leu Arg Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Tyr Arg Arg Ile Thr Pro Trp Glu Ala Ser Gly Asn Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     

<210>  29
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4H9 CDR1


<400>  29
Gly Pro Ile Ala Arg Ser Arg Ser 
1               5               

<210>  30
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  4H9 CDR2


<400>  30
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr 
1               5                   10  

<210>  31
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  4H9 CDR3


<400>  31
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  32
<211>  127
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(127)
<223>  4H9 VHH


<400>  32
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ala Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Pro Ile Ala Arg Ser Arg 
            20                  25                  30          
Ser Thr Gly Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Ser Val Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala 
65                  70                  75                  80  
Ala Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln 
            100                 105                 110         
Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         

<210>  33
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  10H5 CDR1


<400>  33
Glu Thr Thr Phe Lys Ser Met Ala 
1               5               

<210>  34
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  10H5 CDR2


<400>  34
Thr Asn Tyr Asn Gly Gly Arg Thr 
1               5               

<210>  35
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(17)
<223>  10H5 CDR3


<400>  35
Ala Ala Lys Ala Thr Glu Gly Thr Thr Phe Pro Ser Arg Thr Tyr Glu 
1               5                   10                  15      
Phe 
    

<210>  36
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  10H5 VHH


<400>  36
Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Thr 
1               5                   10                  15      
Ala Ser Asp Pro Pro Phe Ala Asn Tyr Glu Thr Thr Phe Lys Ser Met 
            20                  25                  30          
Ala Met Gly Trp Val Arg His Ile Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Ala Thr Asn Tyr Asn Gly Gly Arg Thr Trp Tyr Ser Asn Ser Ala 
    50                  55                  60                  
Lys Ala Arg Ser Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Ala Thr Glu Gly Thr Thr Phe Pro Ser Arg Thr Tyr Glu 
            100                 105                 110         
Phe Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  37
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  12H7 CDR1


<400>  37
Gly Asn Phe Leu Ser Val Ser Asp 
1               5               

<210>  38
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  12H7 CDR2


<400>  38
Val Thr Glu His Gly Arg Thr 
1               5           

<210>  39
<211>  20
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  12H7 CDR3


<400>  39
Lys Ala Ser Asp Val Phe Thr Asp Ala Gly Ala His Glu Ala Val Leu 
1               5                   10                  15      
Ile Arg Asp Tyr 
            20  

<210>  40
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(126)
<223>  12H7 VHH


<400>  40
Gln Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Asn Phe Leu Ser Val Ser 
            20                  25                  30          
Asp Met Ser Trp Tyr Arg Gln Ala Pro Gly Met Glu Arg Asp Val Val 
        35                  40                  45              
Ala Thr Val Thr Glu His Gly Arg Thr Thr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu His Thr Thr Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Lys 
                85                  90                  95      
Ala Ser Asp Val Phe Thr Asp Ala Gly Ala His Glu Ala Val Leu Ile 
            100                 105                 110         
Arg Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  41
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  13H11 CDR1


<400>  41
Gly Leu Thr Phe Ser Met Tyr Ala 
1               5               

<210>  42
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  13H11 CDR2


<400>  42
Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  43
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  13H11 CDR3


<400>  43
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  44
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  13H11 VHH


<400>  44
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Met Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 

<210>  45
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  15A5 CDR1


<400>  45
Glu Arg Thr Phe Ser Ser Phe Ala 
1               5               

<210>  46
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  15A5 CDR2


<400>  46
Ile Asp Pro Ser Gly Arg Tyr Ile 
1               5               

<210>  47
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  15A5 CDR3


<400>  47
Ala Ala Arg Ile Arg Gly Glu Gly Tyr Tyr Thr Arg Ser Ser Phe Tyr 
1               5                   10                  15      
His Tyr 
        

<210>  48
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  15A5 VHH


<400>  48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Ser Phe 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              
Ala Ala Ile Asp Pro Ser Gly Arg Tyr Ile Tyr Tyr Lys Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Ile Arg Gly Glu Gly Tyr Tyr Thr Arg Ser Ser Phe Tyr 
            100                 105                 110         
His Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 

<210>  49
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2B7 CDR1


<400>  49
Gly Arg Thr Phe Ser Ser Tyr Pro 
1               5               

<210>  50
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2B7 CDR2


<400>  50
Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  51
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2B7 CDR3


<400>  51
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  52
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2B7 VHH


<400>  52
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 

<210>  53
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2B10 CDR1


<400>  53
Ser Arg Ile Phe Arg Arg Tyr Ala 
1               5               

<210>  54
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2B10 CDR2


<400>  54
Ile Thr Trp Ser Gly Ala Ser Thr 
1               5               

<210>  55
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(17)
<223>  2B10 CDR3


<400>  55
Ala Ala Asp Pro Trp Gly Ser Val Ile Val Gly Thr Ala Glu Tyr Glu 
1               5                   10                  15      
Tyr 
    

<210>  56
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  2B10 VHH


<400>  56
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Arg Arg Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Thr Trp Ser Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Glu Asn Thr Thr Tyr 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Pro Trp Gly Ser Val Ile Val Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 

<210>  57
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  3F10 CDR1


<400>  57
Glu His Thr Phe Ser Asn Phe Pro 
1               5               

<210>  58
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  3F10 CDR2


<400>  58
Ile Asp Ser Ser Gly Arg Leu Thr 
1               5               

<210>  59
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  3F10 CDR3


<400>  59
Ala Ala Arg Thr Gly Gly Val Gly Tyr Tyr Ser Arg Ser Ser Phe Tyr 
1               5                   10                  15      
Asn Tyr 
        

<210>  60
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  3F10 VHH


<400>  60
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ser Ser Glu His Thr Phe Ser Asn Phe 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asn Val Val 
        35                  40                  45              
Ala Ala Ile Asp Ser Ser Gly Arg Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Thr Gly Gly Val Gly Tyr Tyr Ser Arg Ser Ser Phe Tyr 
            100                 105                 110         
Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  61
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  3G6 CDR1


<400>  61
Gly Ser Ile Phe Gly Ile Ser Val 
1               5               

<210>  62
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  3G6 CDR2


<400>  62
Leu Thr Arg Ala Gly Leu Thr 
1               5           

<210>  63
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(15)
<223>  3G6 CDR3


<400>  63
His Ala Asn Ile Met Glu Ser Ala Ala Ser Thr Phe Gly Arg Tyr 
1               5                   10                  15  

<210>  64
<211>  121
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(121)
<223>  3G6 VHH


<400>  64
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Gly Ile Ser 
            20                  25                  30          
Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Asp Leu Val 
        35                  40                  45              
Ala Thr Leu Thr Arg Ala Gly Leu Thr Thr Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Ser Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      
Ala Asn Ile Met Glu Ser Ala Ala Ser Thr Phe Gly Arg Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     

<210>  65
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  3G7 CDR1


<400>  65
Gly Arg Thr Leu Ser Thr Tyr Thr 
1               5               

<210>  66
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  3G7 CDR2


<400>  66
Ala Trp Pro Ser Pro Ser Thr 
1               5           

<210>  67
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  3G7 CDR3


<400>  67
Ala Ala Asp Tyr Lys Ser Leu Thr Gln Ser Trp Leu Asn Ala Ala Leu 
1               5                   10                  15      
Asp Tyr 
        

<210>  68
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  3G7 VHH


<400>  68
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Leu Ser Thr Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Gly Leu Ala Trp Pro Ser Pro Ser Thr Tyr Val Val Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Ala Asp Tyr Lys Ser Leu Thr Gln Ser Trp Leu Asn Ala Ala Leu Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  69
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  3H7 CDR1


<400>  69
Gly Ser Ile Leu Ser Ala Gly Val 
1               5               

<210>  70
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  3H7 CDR2


<400>  70
Ile Ala Leu Asp Gly Ser Thr Gly 
1               5               

<210>  71
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(15)
<223>  3H7 CDR3


<400>  71
Asn Ala Asn Ile Arg Thr Asp Met Arg Ser Ala Pro Phe Asp His 
1               5                   10                  15  

<210>  72
<211>  122
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(122)
<223>  3H7 VHH


<400>  72
Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Ser Ala Gly 
            20                  25                  30          
Val Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Ser Ile Ala Leu Asp Gly Ser Thr Gly Tyr Tyr Ile Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr 
65                  70                  75                  80  
Leu Asp Met Arg Ser Leu Glu Pro Ala Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      
Asn Ala Asn Ile Arg Thr Asp Met Arg Ser Ala Pro Phe Asp His Trp 
            100                 105                 110         
Gly His Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  73
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4C6 CDR1


<400>  73
Gly Arg Thr Phe Ser Ser Tyr Pro 
1               5               

<210>  74
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  4C6 CDR2


<400>  74
Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  75
<211>  16
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  4C6 CDR3


<400>  75
Ala Val Asp Pro Thr Gly Trp Gly Thr Ile Glu Ala Asp Phe Arg Ser 
1               5                   10                  15      

<210>  76
<211>  123
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(123)
<223>  4C6 VHH


<400>  76
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Arg Cys 
                85                  90                  95      
Ala Val Asp Pro Thr Gly Trp Gly Thr Ile Glu Ala Asp Phe Arg Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210>  77
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1C12 CDR1


<400>  77
Ser Arg Ile Phe Ser Arg Tyr Gly 
1               5               

<210>  78
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1C12 CDR2


<400>  78
Ile Ser Trp Asn Gly Ala Ser Thr 
1               5               

<210>  79
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(17)
<223>  1C12 CDR3


<400>  79
Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
1               5                   10                  15      
Tyr 
    

<210>  80
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  1C12 VHH


<400>  80
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Ser Arg Tyr 
            20                  25                  30          
Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Asn Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Glu Asn Thr Thr Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  81
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1G1 CDR1


<400>  81
Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  82
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1G1 CDR2


<400>  82
Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  83
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  1G1 CDR3


<400>  83
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  84
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1G1 VHH


<400>  84
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  85
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1G1-F-G-ERES VHH


<400>  85
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  86
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1G1-F-A-ERES VHH


<400>  86
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  87
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1G1-F-A-EREW VHH


<400>  87
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  88
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1G1-F-A-GLEW VHH


<400>  88
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  89
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1G1-F-A-GREL VHH


<400>  89
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  90
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1G1-F-A-GRES VHH


<400>  90
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  91
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  1C12-EREF VHH


<400>  91
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Ser Arg Tyr 
            20                  25                  30          
Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Asn Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  92
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  1C12-EREW VHH


<400>  92
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Ser Arg Tyr 
            20                  25                  30          
Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Asn Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  93
<211>  124
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(124)
<223>  1C12_GLEW VHH


<400>  93
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Ser Arg Tyr 
            20                  25                  30          
Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Asn Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210>  94
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 CDR1


<400>  94
Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  95
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 CDR2


<400>  95
Ile Ser Ser Asp Met Arg Phe Thr 
1               5               

<210>  96
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2A3 CDR3


<400>  96
Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  97
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2A3 VHH


<400>  97
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Met Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  98
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1A8 CDR1


<400>  98
Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  99
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1A8 CDR2


<400>  99
Ile Ser Ser Arg Gly Arg Phe Thr 
1               5               

<210>  100
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  1A8 CDR3


<400>  100
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  101
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1A8 VHH


<400>  101
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Arg Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  102
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1D11 CDR1


<400>  102
Gly Pro Ser Phe Ser Ser Ser Pro 
1               5               

<210>  103
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1D11 CDR2


<400>  103
Ile Ser Ser Met Gly Arg Phe Thr 
1               5               

<210>  104
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  1D11 CDR3


<400>  104
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  105
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1D11 VHH


<400>  105
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Ser 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Met Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  106
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  5E8 CDR1


<400>  106
Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  107
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  5E8 CDR2


<400>  107
Gln Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  108
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  5E8 CDR3


<400>  108
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  109
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  5E8 VHH


<400>  109
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Gln Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  110
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A5 CDR1


<400>  110
Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  111
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A5 CDR2


<400>  111
Ile Ser Ser Val Gly Arg Phe Thr 
1               5               

<210>  112
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2A5 CDR3


<400>  112
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Trp Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  113
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2A5 VHH


<400>  113
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Val Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Trp Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  114
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  5G10 CDR1


<400>  114
Gly Pro Arg Phe Ser Ser Tyr Pro 
1               5               

<210>  115
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  5G10 CDR2


<400>  115
Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  116
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  5G10 CDR3


<400>  116
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Gly 
        

<210>  117
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  5G10 VHH


<400>  117
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Arg Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  118
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A6 CDR1


<400>  118
Gly Pro Ser Phe Ser Leu Tyr Pro 
1               5               

<210>  119
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A6 CDR2


<400>  119
Ile Ser Ser Asp Arg Arg Phe Thr 
1               5               

<210>  120
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2A6 CDR3


<400>  120
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  121
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2A6 VHH


<400>  121
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Leu Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Arg Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  122
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1G1-1C12 CDR1


<400>  122
Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  123
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1G1-1C12 CDR2


<400>  123
Ile Ser Ser Asp Leu Arg Phe Thr 
1               5               

<210>  124
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  1G1-1C12 CDR3


<400>  124
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Lys Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  125
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1G1-1C12 VHH


<400>  125
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Lys Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  126
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  5B5 CDR1


<400>  126
Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  127
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  5B5 CDR2


<400>  127
Ile Ser Ser Asp Thr Arg Phe Thr 
1               5               

<210>  128
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  5B5 CDR3


<400>  128
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Arg 
        

<210>  129
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  5B5 VHH


<400>  129
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Thr Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  130
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6F12 CDR1


<400>  130
Gly Pro Ser Phe Thr Ser Tyr Pro 
1               5               

<210>  131
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6F12 CDR2


<400>  131
Ile Ser Ser Asp Gly Arg Phe Lys 
1               5               

<210>  132
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  6F12 CDR3


<400>  132
Ala Ala Glu Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  133
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  6F12 VHH


<400>  133
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Thr Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Glu Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  134
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1C7 CDR1


<400>  134
Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  135
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1C7 CDR2


<400>  135
Ile Ser Ser Arg Gly Arg Phe Thr 
1               5               

<210>  136
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  1C7 CDR3


<400>  136
Ala Ala Arg Gly Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  137
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1C7 VHH


<400>  137
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Arg Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Gly Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  138
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6E9 CDR1


<400>  138
Gly Pro Ser Arg Ser Ser Tyr Pro 
1               5               

<210>  139
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6E9 CDR2


<400>  139
Ile Ser Ser Asp Gly Lys Phe Thr 
1               5               

<210>  140
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  6E9 CDR3


<400>  140
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Asn Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  141
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  6E9 VHH


<400>  141
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Arg Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Lys Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Asn Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  142
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1A10 CDR1


<400>  142
Gly Asn Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  143
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  1A10 CDR2


<400>  143
Ile Ser Ser Asp Gly Arg Phe Ser 
1               5               

<210>  144
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  1A10 CDR3


<400>  144
Ala Cys Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  145
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  1A10 VHH


<400>  145
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Cys Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  146
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6B11 CDR1


<400>  146
Gly Pro Ser Phe Pro Ser Tyr Pro 
1               5               

<210>  147
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6B11 CDR2


<400>  147
Ile Ser Ser Arg Gly Arg Phe Thr 
1               5               

<210>  148
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  6B11 CDR3


<400>  148
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Leu Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  149
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  6B11 VHH


<400>  149
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Pro Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Arg Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Leu Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  150
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6D8 CDR1


<400>  150
Gly Pro Ser Phe Ser Ser Lys Pro 
1               5               

<210>  151
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6D8 CDR2


<400>  151
Arg Ser Ser Asp Gly Arg Phe Thr 
1               5               

<210>  152
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  6D8 CDR3


<400>  152
Ala Ala Arg Asp Ser Gly Ser Gly Arg Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  153
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  6D8 VHH


<400>  153
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Lys 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Arg Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Arg Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  154
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6D12 CDR1


<400>  154
Gly Pro Ser Phe Ser Thr Tyr Pro 
1               5               

<210>  155
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  6D12 CDR2


<400>  155
Ile Ser Ser Asp Gly Val Phe Thr 
1               5               

<210>  156
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  6D12 CDR3


<400>  156
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Glu Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  157
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  6D12 VHH


<400>  157
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Thr Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Val Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Glu Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  158
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2C5 CDR1


<400>  158
Gly Pro Ser Phe Ser Thr Tyr Pro 
1               5               

<210>  159
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2C5 CDR2


<400>  159
Ile Ser Ser Gln Gly Arg Phe Thr 
1               5               

<210>  160
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2C5 CDR3


<400>  160
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  161
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2C5 VHH


<400>  161
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Thr Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Gln Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  162
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  7F6 CDR1


<400>  162
Gly Pro Met Phe Ser Ser Tyr Pro 
1               5               

<210>  163
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  7F6 CDR2


<400>  163
Ile Ser Ser Asp Pro Arg Phe Thr 
1               5               

<210>  164
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  7F6 CDR3


<400>  164
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  165
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  7F6 VHH


<400>  165
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Met Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Pro Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  166
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2D5 CDR1


<400>  166
Gly Pro Ser Phe Ser Ser Ser Pro 
1               5               

<210>  167
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2D5 CDR2


<400>  167
Ile Ser Trp Asp Gly Arg Phe Thr 
1               5               

<210>  168
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2D5 CDR3


<400>  168
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Val Tyr 
        

<210>  169
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2D5 VHH


<400>  169
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Ser 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  170
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  7B11 CDR1


<400>  170
Gly Pro Ser Phe Leu Ile Tyr Pro 
1               5               

<210>  171
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  7B11 CDR2


<400>  171
Ile Ser Ser Asp Gly Arg Phe Trp 
1               5               

<210>  172
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  7B11 CDR3


<400>  172
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Val Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  173
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  7B11 VHH


<400>  173
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Leu Ile Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Trp Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Val Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  174
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  7D12 CDR1


<400>  174
Gly Pro Ser Phe Leu Ser Tyr Pro 
1               5               

<210>  175
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  7D12 CDR2


<400>  175
Ile Ser Ser Asp Gly Arg Phe Ser 
1               5               

<210>  176
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  7D12 CDR3


<400>  176
Ala Ala Arg Asp Trp Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  177
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  7D12 VHH


<400>  177
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Leu Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Gly Arg Phe Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Trp Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  178
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 ML CDR1


<400>  178
Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  179
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 ML CDR2


<400>  179
Ile Ser Ser Asp Leu Arg Phe Thr 
1               5               

<210>  180
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2A3 ML CDR3


<400>  180
Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  181
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2A3 ML VHH


<400>  181
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  182
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 MI CDR1


<400>  182
Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  183
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 MI CDR2


<400>  183
Ile Ser Ser Asp Ile Arg Phe Thr 
1               5               

<210>  184
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2A3 MI CDR3


<400>  184
Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  185
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2A3 MI VHH


<400>  185
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Ile Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  186
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 ML DT CDR1


<400>  186
Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  187
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 ML DT CDR2


<400>  187
Ile Ser Ser Asp Leu Arg Phe Thr 
1               5               

<210>  188
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2A3 ML DT CDR3


<400>  188
Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  189
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2A3 ML DT VHH


<400>  189
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  190
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 ML DE CDR1


<400>  190
Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               

<210>  191
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  2A3 ML DE CDR2


<400>  191
Ile Ser Ser Asp Leu Arg Phe Thr 
1               5               

<210>  192
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  2A3 ML DE CDR3


<400>  192
Ala Ala Arg Glu Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      
Asp Tyr 
        

<210>  193
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(125)
<223>  2A3 ML DE VHH


<400>  193
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Glu Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  194
<211>  357
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(357)
<223>  2A3 LTFc


<400>  194
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys 
        115                 120                 125             
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         
Leu Ser Pro Gly Lys 
        355         

<210>  195
<211>  12
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  Exemplary linker195


<400>  195
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10          

<210>  196
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(15)
<223>  Exemplary linker196


<400>  196
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210>  197
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Exemplary linker197


<400>  197
Gly Gly Gly Ser Gly 
1               5   

<210>  198
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  Exemplary linker198


<400>  198
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  

<210>  199
<211>  8
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  Exemplary linker199


<400>  199
Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               

<210>  200
<211>  12
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  Exemplary linker200


<400>  200
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          

<210>  201
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(6)
<223>  Exemplary linker201


<400>  201
Gly Ser Gly Gly Ser Gly 
1               5       

<210>  202
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  Exemplary linker202


<400>  202
Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   

<210>  203
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Exemplary linker203


<400>  203
Gly Ser Gly Ser Gly Ser Gly 
1               5           

<210>  204
<211>  18
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(18)
<223>  Exemplary linker204


<400>  204
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly 
        

<210>  205
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(5)
<223>  Exemplary linker205


<400>  205
Pro Ala Pro Ala Pro 
1               5   

<210>  206
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(15)
<223>  Exemplary linker206


<400>  206
Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro 
1               5                   10                  15  

<210>  207
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Exemplary linker207


<400>  207
Ile Lys Arg Thr Val Ala Ala 
1               5           

<210>  208
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Exemplary linker208


<400>  208
Val Ser Ser Ala Ser Thr Lys 
1               5           

<210>  209
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  Exemplary linker209


<400>  209
Ala Glu Ala Ala Ala Lys Ala 
1               5           

<210>  210
<211>  12
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  Exemplary linker210


<400>  210
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          

<210>  211
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  Exemplary linker211


<400>  211
Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser 
1               5                   10  

<210>  212
<211>  20
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  Exemplary linker212


<400>  212
Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser Gly 
1               5                   10                  15      
Arg Pro Gly Ser 
            20  

<210>  213
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  Exemplary linker213


<400>  213
Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser 
1               5                   10  

<210>  214
<211>  20
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  Exemplary linker214


<400>  214
Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser Gly 
1               5                   10                  15      
Arg Gly Gly Ser 
            20  

<210>  215
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  Exemplary linker215


<400>  215
Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser 
1               5                   10  

<210>  216
<211>  20
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  Exemplary linker216


<400>  216
Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly 
1               5                   10                  15      
Lys Pro Gly Ser 
            20  

<210>  217
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  Exemplary linker217


<400>  217
Gly Glu Pro Gly Ser Gly Glu Pro Gly Ser 
1               5                   10  

<210>  218
<211>  20
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  Exemplary linker218


<400>  218
Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly 
1               5                   10                  15      
Glu Gly Gly Ser 
            20  

<210>  219
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  Exemplary linker219


<400>  219
Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser 
1               5                   10  

<210>  220
<211>  20
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(20)
<223>  Exemplary linker220


<400>  220
Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser Gly 
1               5                   10                  15      
Asp Pro Gly Ser 
            20  

<210>  221
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  H1G4 CDR-H1


<400>  221
Phe Thr Phe Ser Asn Tyr Gly Met Ser 
1               5                   

<210>  222
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  H1G4 CDR-H2


<400>  222
Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr 
1               5                   10  

<210>  223
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  H1G4 CDR-H3


<400>  223
Val Ser Tyr Tyr Tyr Gly Ile Asp Phe 
1               5                   

<210>  224
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  H1G4 CDR-L1


<400>  224
Lys Ala Ser Gln Asp Val Thr Thr Ala Val Ala 
1               5                   10      

<210>  225
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  H1G4 CDR-L2


<400>  225
Trp Ala Ser Thr Arg His Thr 
1               5           

<210>  226
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  H1G4 CDR-L3


<400>  226
Gln Gln His Tyr Thr Ile Pro Trp Thr 
1               5                   

<210>  227
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  H1G4 VH


<400>  227
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Tyr Tyr Tyr Gly Ile Asp Phe Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  228
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(108)
<223>  H1G4 VL


<400>  228
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

<210>  229
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  33B CDR-H1


<400>  229
Phe Arg Phe Ser Asn Tyr Gly Met Ser 
1               5                   

<210>  230
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  33B CDR-H2


<400>  230
Thr Ile Ser Gly Gly Gly Ser Asn Ala Tyr 
1               5                   10  

<210>  231
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  33B CDR-H3


<400>  231
Thr Ser Tyr Tyr Tyr Gly Ile Asp Phe 
1               5                   

<210>  232
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  33B CDR-L1


<400>  232
Lys Ala Ser Thr Asp Val Thr Thr Ala Val Ala 
1               5                   10      

<210>  233
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  33B CDR-L2


<400>  233
Trp Ala Ser Leu Arg His Thr 
1               5           

<210>  234
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  33B CDR-L3


<400>  234
Gln Gln His Tyr Gly Ile Pro Trp Thr 
1               5                   

<210>  235
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  33B VH


<400>  235
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Gly Gly Gly Ser Asn Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ser Tyr Tyr Tyr Gly Ile Asp Phe Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  236
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(108)
<223>  33B VL


<400>  236
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Thr Asp Val Thr Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Leu Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Gly Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

<210>  237
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  66E CDR-H1


<400>  237
Phe Thr Phe Ser Asn Tyr Gly Met Ser 
1               5                   

<210>  238
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  66E CDR-H2


<400>  238
Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr 
1               5                   10  

<210>  239
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  66E CDR-H3


<400>  239
Val Ser Tyr Tyr Tyr Gly Ile Asp Leu 
1               5                   

<210>  240
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  66E CDR-L1


<400>  240
Lys Ala Lys Gln Asp Val Thr Thr Ala Val Ala 
1               5                   10      

<210>  241
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  66E CDR-L2


<400>  241
Trp Ala Ser Thr Arg His Thr 
1               5           

<210>  242
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  66E CDR-L3


<400>  242
Gln Gln His Tyr Trp Ile Pro Trp Thr 
1               5                   

<210>  243
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  66E VH


<400>  243
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Tyr Tyr Tyr Gly Ile Asp Leu Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  244
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(108)
<223>  66E VL


<400>  244
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Lys Gln Asp Val Thr Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Trp Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

<210>  245
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  711D CDR-H1


<400>  245
Phe Thr Phe Ser Asn Tyr Gly Met Ser 
1               5                   

<210>  246
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  711D CDR-H2


<400>  246
Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr 
1               5                   10  

<210>  247
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  711D CDR-H3


<400>  247
Ser Ser Tyr Tyr Tyr Gly Ile Asp Leu 
1               5                   

<210>  248
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  711D CDR-L1


<400>  248
Lys Ala Ser Gln Asp Val Thr Asn Ala Val Ala 
1               5                   10      

<210>  249
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  711D CDR-L2


<400>  249
Trp Ala Ser Thr Arg His Thr 
1               5           

<210>  250
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  711D CDR-L3


<400>  250
Gln Gln His Tyr Thr Ile Pro Trp Thr 
1               5                   

<210>  251
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(116)
<223>  711D VH


<400>  251
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Ser Tyr Tyr Tyr Gly Ile Asp Leu Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  252
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(108)
<223>  711D VL


<400>  252
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Asn Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

<210>  253
<211>  580
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<222>  (1)..(580)
<223>  anti-PD1 HC -Linker- 2A3 (HCC heavy chain)


<400>  253
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Tyr Tyr Tyr Gly Ile Asp Phe Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Ser Gly Gly Ser 
        435                 440                 445             
Gly Gly Ser Gly Gly Ser Gly Gln Val Gln Leu Val Glu Ser Gly Gly 
    450                 455                 460                 
Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
465                 470                 475                 480 
Gly Gly Ser Phe Ser Ser Tyr Pro Met Gly Trp Phe Arg Gln Ala Pro 
                485                 490                 495     
Gly Lys Glu Arg Glu Ser Val Ala Ala Ile Ser Ser Asp Leu Arg Phe 
            500                 505                 510         
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        515                 520                 525             
Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    530                 535                 540                 
Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Thr Ser Gly Val Gly Tyr 
545                 550                 555                 560 
Tyr Ser Arg Ala Gln Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                565                 570                 575     
Thr Val Ser Ser 
            580 

<210>  254
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<222>  (1)..(214)
<223>  anti-PD1 LC1 (HCC light chain)


<400>  254
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  255
<211>  443
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<222>  (1)..(443)
<223>  anti-PD1 HC1 (LCC heavy chain)


<400>  255
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Tyr Tyr Tyr Gly Ile Asp Phe Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             

<210>  256
<211>  351
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<222>  (1)..(351)
<223>  anti-PD1 LC-Linker-2A3 (LCC light chain)


<400>  256
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    210                 215                 220                 
Ser Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
225                 230                 235                 240 
Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser 
                245                 250                 255     
Ser Tyr Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            260                 265                 270         
Ser Val Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp 
        275                 280                 285             
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
    290                 295                 300                 
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
305                 310                 315                 320 
Tyr Cys Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln 
                325                 330                 335     
Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            340                 345                 350     

<210>  257
<211>  580
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<222>  (1)..(580)
<223>  2A3-Linker-anti-PD1 HC (HCN heavy chain)


<400>  257
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gln Val Gln Leu Val Glu Ser 
    130                 135                 140                 
Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 
Ala Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met Ser Trp Ile Arg Gln 
                165                 170                 175     
Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly 
            180                 185                 190         
Ser Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             
Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Ser Tyr Tyr Tyr Gly Ile 
225                 230                 235                 240 
Asp Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
            260                 265                 270         
Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
                325                 330                 335     
Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
            340                 345                 350         
Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
385                 390                 395                 400 
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                565                 570                 575     
Ser Leu Gly Lys 
            580 

<210>  258
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<222>  (1)..(214)
<223>  anti-PD1 LC2 (HCN light chain)


<400>  258
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  259
<211>  443
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<222>  (1)..(443)
<223>  anti-PD1 HC2 (LCN heavy chain)


<400>  259
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Ser Gly Gly Gly Ser Asn Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Tyr Tyr Tyr Gly Ile Asp Phe Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             

<210>  260
<211>  351
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<222>  (1)..(351)
<223>  2A3-Linker-anti-PD1 LC (LCN light chain)


<400>  260
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          
Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              
Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             
Gly Ser Gly Gly Ser Gly Gly Ser Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 
Lys Ala Ser Gln Asp Val Thr Thr Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     
Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His 
            180                 185                 190         
Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 
Cys Gln Gln His Tyr Thr Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 
Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
                245                 250                 255     
Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
            260                 265                 270         
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
        275                 280                 285             
Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
    290                 295                 300                 
Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
305                 310                 315                 320 
Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
                325                 330                 335     
Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            340                 345                 350     

<210>  261
<211>  244
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  PEPTIDE
<222>  (1)..(244)
<223>  Human TIGIT polypeptide


<400>  261
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      
Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          
Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              
Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  
Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  
Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      
Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         
Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             
Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 
Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 
Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     
Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         
Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             
Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 
Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 
Thr Glu Thr Gly 
                

<210>  262
<211>  138
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<222>  (1)..(138)
<223>  ECD of Human TIGIT polypeptide


<400>  262
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      
Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          
Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              
Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  
Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  
Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      
Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         
Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             
Ser Ser Val Ala Glu His Gly Ala Arg Phe 
    130                 135             

