                         SEQUENCE LISTING

<110>  Ϻ꺺＼ɷ޹˾
        
<120>  TIGITʹ÷

<130>  SH1903-20P450229

<160>  222   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A11 CDR1

<400>  1

Gly Arg Pro Phe Ser Asn Tyr Thr 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A11 CDR2

<400>  2

Ala Trp Pro Ser Pro Ser Thr 
1               5           


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A11 CDR3

<400>  3

Ala Ala Asp Tyr Lys Ser Leu Thr Gln Ser Trp Leu Asn Ala Ala Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  4
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A11 VHH

<400>  4

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Glu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Pro Phe Ser Asn Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Leu Ala Trp Pro Ser Pro Ser Thr Tyr Val Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Tyr Lys Ser Leu Thr Gln Ser Trp Leu Asn Ala Ala Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B5 CDR1

<400>  5

Pro Arg Thr Phe Ser Thr Phe His 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B5 CDR2

<400>  6

Phe Asn Trp Ser Gly Gly Arg Thr 
1               5               


<210>  7
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B5 CDR3

<400>  7

Ala Ala Ala Arg Asp Arg Gly Leu His Asp Gly Thr Thr Ser Asp Ser 
1               5                   10                  15      


Tyr Leu Glu Gly Ser His Glu Tyr Glu Tyr 
            20                  25      


<210>  8
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B5 VHH

<400>  8

Gln Val Lys Leu Glu Glu Ser Gly Gly Arg Ser Val Leu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Arg Cys Ala Gly Thr Pro Arg Thr Phe Ser Thr Phe 
            20                  25                  30          


His Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Phe Asn Trp Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Gly Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Asp Arg Gly Leu His Asp Gly Thr Thr Ser Asp Ser 
            100                 105                 110         


Tyr Leu Glu Gly Ser His Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4C5 CDR1

<400>  9

Gly Arg Ser Val Ser Thr Tyr Phe 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4C5 CDR2

<400>  10

Ile Asp Arg Gly Ser Thr Val Thr 
1               5               


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4C5 CDR3

<400>  11

Ala Ala Lys Ala Ile Thr Arg Asn Phe Ile Ala Thr Asn Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  12
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4C5 VHH

<400>  12

Gln Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Ser Val Ser Thr Tyr 
            20                  25                  30          


Phe Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asp Arg Gly Ser Thr Val Thr Arg Tyr Asp Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Ala Ile Thr Arg Asn Phe Ile Ala Thr Asn Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR1

<400>  13

Gly Arg Ala Phe Asn Glu Tyr Ala 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR2

<400>  14

Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 CDR3

<400>  15

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  16
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D5 VHH

<400>  16

Val Asp Ser Gly Gly Gly Ala Val Lys Ala Gly Asp Ser Leu Arg Leu 
1               5                   10                  15      


Val Cys Ser Ala Pro Gly Arg Thr His Gly Arg Ala Phe Asn Glu Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D11 CDR1

<400>  17

Gly Ser Ile Ser Ser Ile Asn Ala 
1               5               


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D11 CDR2

<400>  18

Ile Thr Asn Ser Gly Ser Thr 
1               5           


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D11 CDR3

<400>  19

Thr Ala Arg Arg Ser Thr Trp Tyr Ile Ser 
1               5                   10  


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4D11 VHH

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Leu Ala Pro Gly Lys His Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Thr Asn Ser Gly Ser Thr Asn Tyr Ala Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Asn Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Phe Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ala Arg Arg Ser Thr Trp Tyr Ile Ser Ser Gly Arg Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E5 CDR1

<400>  21

Gly Leu Thr Ser Ser Asp Ile Ala 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E5 CDR2

<400>  22

Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E5 CDR3

<400>  23

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  24
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4E5 VHH

<400>  24

Gln Val Gln Leu Val Asp Ser Gly Gly Gly Val Val Glu Val Gly Ala 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Glu Thr Ser Gly Leu Thr Ser Ser Asp Ile 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H6 CDR1

<400>  25

Gly Thr Ile Phe Arg Leu Asn Arg 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H6 CDR2

<400>  26

Thr Ile Trp Ser Gly Arg Arg Thr 
1               5               


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H6 CDR3

<400>  27

Asn Tyr Arg Arg Ile Thr Pro Trp Glu Ala Ser Gly Asn Tyr 
1               5                   10                  


<210>  28
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H6 VHH

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Thr Ala Gly Ala 
1               5                   10                  15      


Ser Leu Ile Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Arg Leu Asn 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Ala Thr Ile Trp Ser Gly Arg Arg Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Tyr Arg Arg Ile Thr Pro Trp Glu Ala Ser Gly Asn Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H9 CDR1

<400>  29

Gly Pro Ile Ala Arg Ser Arg Ser 
1               5               


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H9 CDR2

<400>  30

Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr 
1               5                   10  


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H9 CDR3

<400>  31

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  32
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H9 VHH

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ala Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Pro Ile Ala Arg Ser Arg 
            20                  25                  30          


Ser Thr Gly Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Ser Val Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala 
65                  70                  75                  80  


Ala Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln 
            100                 105                 110         


Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10H5 CDR1

<400>  33

Glu Thr Thr Phe Lys Ser Met Ala 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETTFKSMA

<400>  34

Thr Asn Tyr Asn Gly Gly Arg Thr 
1               5               


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10H5 CDR3

<400>  35

Ala Ala Lys Ala Thr Glu Gly Thr Thr Phe Pro Ser Arg Thr Tyr Glu 
1               5                   10                  15      


Phe 
    


<210>  36
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10H5 VHH

<400>  36

Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Thr 
1               5                   10                  15      


Ala Ser Asp Pro Pro Phe Ala Asn Tyr Glu Thr Thr Phe Lys Ser Met 
            20                  25                  30          


Ala Met Gly Trp Val Arg His Ile Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Thr Asn Tyr Asn Gly Gly Arg Thr Trp Tyr Ser Asn Ser Ala 
    50                  55                  60                  


Lys Ala Arg Ser Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Ala Thr Glu Gly Thr Thr Phe Pro Ser Arg Thr Tyr Glu 
            100                 105                 110         


Phe Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12H7 CDR1

<400>  37

Gly Asn Phe Leu Ser Val Ser Asp 
1               5               


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12H7 CDR2

<400>  38

Val Thr Glu His Gly Arg Thr 
1               5           


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12H7 CDR3

<400>  39

Lys Ala Ser Asp Val Phe Thr Asp Ala Gly Ala His Glu Ala Val Leu 
1               5                   10                  15      


Ile Arg Asp Tyr 
            20  


<210>  40
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12H7 VHH

<400>  40

Gln Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Val Ser Gly Asn Phe Leu Ser Val Ser 
            20                  25                  30          


Asp Met Ser Trp Tyr Arg Gln Ala Pro Gly Met Glu Arg Asp Val Val 
        35                  40                  45              


Ala Thr Val Thr Glu His Gly Arg Thr Thr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu His Thr Thr Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Lys 
                85                  90                  95      


Ala Ser Asp Val Phe Thr Asp Ala Gly Ala His Glu Ala Val Leu Ile 
            100                 105                 110         


Arg Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13H11 CDR1

<400>  41

Gly Leu Thr Phe Ser Met Tyr Ala 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13H11 CDR2

<400>  42

Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13H11 CDR3

<400>  43

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  44
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13H11 VHH

<400>  44

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Met Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A5 CDR1

<400>  45

Glu Arg Thr Phe Ser Ser Phe Ala 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A5 CDR2

<400>  46

Ile Asp Pro Ser Gly Arg Tyr Ile 
1               5               


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A5 CDR3

<400>  47

Ala Ala Arg Ile Arg Gly Glu Gly Tyr Tyr Thr Arg Ser Ser Phe Tyr 
1               5                   10                  15      


His Tyr 
        


<210>  48
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A5 VHH

<400>  48

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Ala Ile Asp Pro Ser Gly Arg Tyr Ile Tyr Tyr Lys Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ile Arg Gly Glu Gly Tyr Tyr Thr Arg Ser Ser Phe Tyr 
            100                 105                 110         


His Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B7 CDR1

<400>  49

Gly Arg Thr Phe Ser Ser Tyr Pro 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B7 CDR2

<400>  50

Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B7 CDR3

<400>  51

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  52
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B7 VHH

<400>  52

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10 CDR1

<400>  53

Ser Arg Ile Phe Arg Arg Tyr Ala 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10 CDR2

<400>  54

Ile Thr Trp Ser Gly Ala Ser Thr 
1               5               


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10 CDR3

<400>  55

Ala Ala Asp Pro Trp Gly Ser Val Ile Val Gly Thr Ala Glu Tyr Glu 
1               5                   10                  15      


Tyr 
    


<210>  56
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B10 VHH

<400>  56

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Arg Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Glu Asn Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Trp Gly Ser Val Ile Val Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 CDR1

<400>  57

Glu His Thr Phe Ser Asn Phe Pro 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 CDR2

<400>  58

Ile Asp Ser Ser Gly Arg Leu Thr 
1               5               


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 CDR3

<400>  59

Ala Ala Arg Thr Gly Gly Val Gly Tyr Tyr Ser Arg Ser Ser Phe Tyr 
1               5                   10                  15      


Asn Tyr 
        


<210>  60
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 VHH

<400>  60

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Glu His Thr Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asn Val Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Ser Gly Arg Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Gly Gly Val Gly Tyr Tyr Ser Arg Ser Ser Phe Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 CDR1

<400>  61

Gly Ser Ile Phe Gly Ile Ser Val 
1               5               


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 CDR2

<400>  62

Leu Thr Arg Ala Gly Leu Thr 
1               5           


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 CDR3

<400>  63

His Ala Asn Ile Met Glu Ser Ala Ala Ser Thr Phe Gly Arg Tyr 
1               5                   10                  15  


<210>  64
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G6 VHH

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Gly Ile Ser 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Glu Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Thr Leu Thr Arg Ala Gly Leu Thr Thr Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Asn Ile Met Glu Ser Ala Ala Ser Thr Phe Gly Arg Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G7 CDR1

<400>  65

Gly Arg Thr Leu Ser Thr Tyr Thr 
1               5               


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G7 CDR2

<400>  66

Ala Trp Pro Ser Pro Ser Thr 
1               5           


<210>  67
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G7 CDR3

<400>  67

Ala Ala Asp Tyr Lys Ser Leu Thr Gln Ser Trp Leu Asn Ala Ala Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  68
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G7 VHH

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Thr Leu Ser Thr Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Leu Ala Trp Pro Ser Pro Ser Thr Tyr Val Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Tyr Lys Ser Leu Thr Gln Ser Trp Leu Asn Ala Ala Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3H7 CDR1

<400>  69

Gly Ser Ile Leu Ser Ala Gly Val 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3H7 CDR2

<400>  70

Ile Ala Leu Asp Gly Ser Thr Gly 
1               5               


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3H7 CDR3

<400>  71

Asn Ala Asn Ile Arg Thr Asp Met Arg Ser Ala Pro Phe Asp His 
1               5                   10                  15  


<210>  72
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3H7 VHH

<400>  72

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Ser Ala Gly 
            20                  25                  30          


Val Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ala Leu Asp Gly Ser Thr Gly Tyr Tyr Ile Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Val Tyr 
65                  70                  75                  80  


Leu Asp Met Arg Ser Leu Glu Pro Ala Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      


Asn Ala Asn Ile Arg Thr Asp Met Arg Ser Ala Pro Phe Asp His Trp 
            100                 105                 110         


Gly His Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4C6 CDR1

<400>  73

Gly Arg Thr Phe Ser Ser Tyr Pro 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4C6 CDR2

<400>  74

Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4C6 CDR3

<400>  75

Ala Val Asp Pro Thr Gly Trp Gly Thr Ile Glu Ala Asp Phe Arg Ser 
1               5                   10                  15      


<210>  76
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4C6 VHH

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Arg Cys 
                85                  90                  95      


Ala Val Asp Pro Thr Gly Trp Gly Thr Ile Glu Ala Asp Phe Arg Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C12 CDR1

<400>  77

Ser Arg Ile Phe Ser Arg Tyr Gly 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C12 CDR2

<400>  78

Ile Ser Trp Asn Gly Ala Ser Thr 
1               5               


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C12 CDR3

<400>  79

Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
1               5                   10                  15      


Tyr 
    


<210>  80
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C12 VHH

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Glu Asn Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1 CDR1

<400>  81

Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1 CDR2

<400>  82

Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  83
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1 CDR3

<400>  83

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  84
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1 VHH

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Ser Ala Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  85
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-F-G-ERES VHH

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  86
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-F-A-ERES VHH

<400>  86

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  87
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-F-A-EREW VHH

<400>  87

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  88
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-F-A-GLEW VHH

<400>  88

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  89
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-F-A-GREL VHH

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  90
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-F-A-GRES VHH

<400>  90

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  91
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C12-EREF VHH

<400>  91

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  92
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C12-EREW VHH

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  93
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C12_GLEW VHH

<400>  93

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Arg Ile Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Ala Ser Thr Thr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Trp Gly Ala Val Lys Leu Gly Thr Ala Glu Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 CDR1

<400>  94

Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 CDR2

<400>  95

Ile Ser Ser Asp Met Arg Phe Thr 
1               5               


<210>  96
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 CDR3

<400>  96

Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  97
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 VHH

<400>  97

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Met Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDR1

<400>  98

Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDR2

<400>  99

Ile Ser Ser Arg Gly Arg Phe Thr 
1               5               


<210>  100
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 CDR3

<400>  100

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  101
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A8 VHH

<400>  101

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Arg Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D11 CDR1

<400>  102

Gly Pro Ser Phe Ser Ser Ser Pro 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D11 CDR2

<400>  103

Ile Ser Ser Met Gly Arg Phe Thr 
1               5               


<210>  104
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D11 CDR3

<400>  104

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  105
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1D11 VHH

<400>  105

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Ser 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Met Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E8 CDR1

<400>  106

Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E8 CDR2

<400>  107

Gln Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  108
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E8 CDR3

<400>  108

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  109
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5E8 VHH

<400>  109

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Gln Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A5 CDR1

<400>  110

Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A5 CDR2

<400>  111

Ile Ser Ser Val Gly Arg Phe Thr 
1               5               


<210>  112
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A5 CDR3

<400>  112

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Trp Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  113
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A5 VHH

<400>  113

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Val Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Trp Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G10 CDR1

<400>  114

Gly Pro Arg Phe Ser Ser Tyr Pro 
1               5               


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G10 CDR2

<400>  115

Ile Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  116
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G10 CDR3

<400>  116

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Gly 
        


<210>  117
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5G10 VHH

<400>  117

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Arg Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A6 CDR1

<400>  118

Gly Pro Ser Phe Ser Leu Tyr Pro 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A6 CDR2

<400>  119

Ile Ser Ser Asp Arg Arg Phe Thr 
1               5               


<210>  120
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A6 CDR3

<400>  120

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  121
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A6 VHH

<400>  121

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Leu Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Arg Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-1C12 CDR1

<400>  122

Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-1C12 CDR2

<400>  123

Ile Ser Ser Asp Leu Arg Phe Thr 
1               5               


<210>  124
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G1-1C12 CDR3

<400>  124

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Lys Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  125
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C12 VHH

<400>  125

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Lys Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5B5 CDR1

<400>  126

Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5B5 CDR2

<400>  127

Ile Ser Ser Asp Thr Arg Phe Thr 
1               5               


<210>  128
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5B5 CDR3

<400>  128

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Arg 
        


<210>  129
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5B5 VHH

<400>  129

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Thr Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6F12 CDR1

<400>  130

Gly Pro Ser Phe Thr Ser Tyr Pro 
1               5               


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6F12 CDR2

<400>  131

Ile Ser Ser Asp Gly Arg Phe Lys 
1               5               


<210>  132
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6F12 CDR3

<400>  132

Ala Ala Glu Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  133
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6F12 VHH

<400>  133

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Thr Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C7 CDR1

<400>  134

Gly Pro Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C7 CDR2

<400>  135

Ile Ser Ser Arg Gly Arg Phe Thr 
1               5               


<210>  136
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C7 CDR3

<400>  136

Ala Ala Arg Gly Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  137
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1C7 VHH

<400>  137

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Arg Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gly Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E9 CDR1

<400>  138

Gly Pro Ser Arg Ser Ser Tyr Pro 
1               5               


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E9 CDR2

<400>  139

Ile Ser Ser Asp Gly Lys Phe Thr 
1               5               


<210>  140
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E9 CDR3

<400>  140

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Asn Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  141
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6E9 VHH

<400>  141

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Arg Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Lys Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Asn Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A10 CDR1

<400>  142

Gly Asn Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A10 CDR2

<400>  143

Ile Ser Ser Asp Gly Arg Phe Ser 
1               5               


<210>  144
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A10 CDR3

<400>  144

Ala Cys Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  145
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1A10 VHH

<400>  145

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Cys Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6B11 CDR1

<400>  146

Gly Pro Ser Phe Pro Ser Tyr Pro 
1               5               


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6B11 CDR2

<400>  147

Ile Ser Ser Arg Gly Arg Phe Thr 
1               5               


<210>  148
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6B11 CDR3

<400>  148

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Leu Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  149
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6B11 VHH

<400>  149

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Pro Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Arg Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Leu Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D8 CDR1

<400>  150

Gly Pro Ser Phe Ser Ser Lys Pro 
1               5               


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D8 CDR2

<400>  151

Arg Ser Ser Asp Gly Arg Phe Thr 
1               5               


<210>  152
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D8 CDR3

<400>  152

Ala Ala Arg Asp Ser Gly Ser Gly Arg Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  153
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D8 VHH

<400>  153

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Lys 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Arg Ser Ser Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Arg Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D12 CDR1

<400>  154

Gly Pro Ser Phe Ser Thr Tyr Pro 
1               5               


<210>  155
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D12 CDR2

<400>  155

Ile Ser Ser Asp Gly Val Phe Thr 
1               5               


<210>  156
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D12 CDR3

<400>  156

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Glu Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  157
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6D12 VHH

<400>  157

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Thr Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Val Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Glu Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  158
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C5 CDR1

<400>  158

Gly Pro Ser Phe Ser Thr Tyr Pro 
1               5               


<210>  159
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C5 CDR2

<400>  159

Ile Ser Ser Gln Gly Arg Phe Thr 
1               5               


<210>  160
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C5 CDR3

<400>  160

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  161
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2C5 VHH

<400>  161

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Thr Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gln Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7F6 CDR1

<400>  162

Gly Pro Met Phe Ser Ser Tyr Pro 
1               5               


<210>  163
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7F6 CDR2

<400>  163

Ile Ser Ser Asp Pro Arg Phe Thr 
1               5               


<210>  164
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7F6 CDR3

<400>  164

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  165
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7F6 VHH

<400>  165

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Met Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Pro Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D5 CDR1

<400>  166

Gly Pro Ser Phe Ser Ser Ser Pro 
1               5               


<210>  167
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D5 CDR2

<400>  167

Ile Ser Trp Asp Gly Arg Phe Thr 
1               5               


<210>  168
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D5 CDR3

<400>  168

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Val Tyr 
        


<210>  169
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D5 VHH

<400>  169

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Ser Ser Ser 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  170
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7B11 CDR1

<400>  170

Gly Pro Ser Phe Leu Ile Tyr Pro 
1               5               


<210>  171
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7B11 CDR2

<400>  171

Ile Ser Ser Asp Gly Arg Phe Trp 
1               5               


<210>  172
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7B11 CDR3

<400>  172

Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Val Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  173
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7B11 VHH

<400>  173

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Leu Ile Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Trp Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Ser Gly Tyr Tyr Ser Arg Val Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D12 CDR1

<400>  174

Gly Pro Ser Phe Leu Ser Tyr Pro 
1               5               


<210>  175
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D12 CDR2

<400>  175

Ile Ser Ser Asp Gly Arg Phe Ser 
1               5               


<210>  176
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D12 CDR3

<400>  176

Ala Ala Arg Asp Trp Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  177
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7D12 VHH

<400>  177

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Ser Phe Leu Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Gly Arg Phe Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Trp Gly Ser Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML CDR1

<400>  178

Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  179
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML CDR2

<400>  179

Ile Ser Ser Asp Leu Arg Phe Thr 
1               5               


<210>  180
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML CDR3

<400>  180

Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  181
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML VHH

<400>  181

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  182
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 MI CDR1

<400>  182

Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 MI CDR2

<400>  183

Ile Ser Ser Asp Ile Arg Phe Thr 
1               5               


<210>  184
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 MI CDR3

<400>  184

Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  185
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 MI VHH

<400>  185

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Ile Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asp Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  186
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML DT CDR1

<400>  186

Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  187
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML DT CDR2

<400>  187

Ile Ser Ser Asp Leu Arg Phe Thr 
1               5               


<210>  188
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML DT CDR3

<400>  188

Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  189
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML DT VHH

<400>  189

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  190
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML DE CDR1

<400>  190

Gly Gly Ser Phe Ser Ser Tyr Pro 
1               5               


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML DE CDR2

<400>  191

Ile Ser Ser Asp Leu Arg Phe Thr 
1               5               


<210>  192
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML DE CDR3

<400>  192

Ala Ala Arg Glu Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  193
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 ML DE VHH

<400>  193

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Glu Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  194
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A3 LT Fc

<400>  194

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Asp Leu Arg Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Ser Gly Val Gly Tyr Tyr Ser Arg Ala Gln Trp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys 
        115                 120                 125             


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys 
        355         


<210>  195
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  195

Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10          


<210>  196
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  196

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  197
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  197

Gly Gly Gly Ser Gly 
1               5   


<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  198

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10  


<210>  199
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  199

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  200
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  200

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210>  201
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  201

Gly Ser Gly Gly Ser Gly 
1               5       


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  202

Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  203

Gly Ser Gly Ser Gly Ser Gly 
1               5           


<210>  204
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  204

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  205

Pro Ala Pro Ala Pro 
1               5   


<210>  206
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  206

Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro Pro Ala Pro Ala Pro 
1               5                   10                  15  


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  207

Ile Lys Arg Thr Val Ala Ala 
1               5           


<210>  208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  208

Val Ser Ser Ala Ser Thr Lys 
1               5           


<210>  209
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  209

Ala Glu Ala Ala Ala Lys Ala 
1               5           


<210>  210
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  210

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  211
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  211

Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser 
1               5                   10  


<210>  212
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  212

Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser Gly Arg Pro Gly Ser Gly 
1               5                   10                  15      


Arg Pro Gly Ser 
            20  


<210>  213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  213

Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser 
1               5                   10  


<210>  214
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  214

Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser Gly Arg Gly Gly Ser Gly 
1               5                   10                  15      


Arg Gly Gly Ser 
            20  


<210>  215
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  215

Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser 
1               5                   10  


<210>  216
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  216

Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly 
1               5                   10                  15      


Lys Pro Gly Ser 
            20  


<210>  217
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  217

Gly Glu Pro Gly Ser Gly Glu Pro Gly Ser 
1               5                   10  


<210>  218
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  218

Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly 
1               5                   10                  15      


Glu Gly Gly Ser 
            20  


<210>  219
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  219

Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser 
1               5                   10  


<210>  220
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ʾԽͷ

<400>  220

Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser Gly Asp Pro Gly Ser Gly 
1               5                   10                  15      


Asp Pro Gly Ser 
            20  


<210>  221
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  TIGIT
<222>  (1)..(244)

<400>  221

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  222
<211>  138
<212>  PRT
<213>  Homo sapiens


<220>
<221>  TIGITĵECD
<222>  (1)..(138)

<400>  222

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe 
    130                 135             


