               SEQUENCE LISTING

<110> HIFIBIO (HK) LIMITED

<120> ANTI-GALECTIN-9 ANTIBODY AND USES THEREOF

<130> CIE210001PCT

<160> 128

<170> BiSSAP 1.3.6

<210> 1
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR1

<400> 1
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210> 2
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 2
Gly Tyr Thr Phe Thr Asp Tyr Thr Ile His 
1               5                   10  

<210> 3
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR2

<400> 3
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 4
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 4
Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly Arg 
        

<210> 5
<211> 31
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR3

<400> 5
Val Thr Met Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu 
1               5                   10                  15      
Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr Arg 
            20                  25                  30      

<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 6
His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   

<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR4

<400> 7
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 8
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> HCVR

<400> 8
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Thr Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 9
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR1

<400> 9
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys 
            20              

<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 10
Lys Ser Ser Gln Ser Leu Phe Tyr Ser Thr Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 11
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR2

<400> 11
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 12
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 13
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR3

<400> 13
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 14
Gln Gln Tyr Tyr Tyr Phe Pro Tyr Thr 
1               5                   

<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR4

<400> 15
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  

<210> 16
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> LCVR

<400> 16
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          
Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Tyr Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 17
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR1

<400> 17
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 18
Gly Tyr Thr Phe Thr Asp Tyr Thr Ile His 
1               5                   10  

<210> 19
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR2

<400> 19
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 20
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 20
Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly Arg 
        

<210> 21
<211> 31
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR3

<400> 21
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
1               5                   10                  15      
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Thr Arg 
            20                  25                  30      

<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 22
His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   

<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR4

<400> 23
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 24
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> HCVR

<400> 24
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Thr Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 25
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR1

<400> 25
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys 
            20              

<210> 26
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 26
Lys Ser Ser Gln Ser Leu Phe Tyr Ser Thr Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR2

<400> 27
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 28
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 29
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR3

<400> 29
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 30
Gln Gln Tyr Tyr Tyr Phe Pro Tyr Thr 
1               5                   

<210> 31
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR4

<400> 31
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  

<210> 32
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> LCVR

<400> 32
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          
Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Tyr Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 33
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR1

<400> 33
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 34
Gly Tyr Thr Phe Thr Asp Tyr Thr Ile His 
1               5                   10  

<210> 35
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR2

<400> 35
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 36
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 36
Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly Arg 
        

<210> 37
<211> 31
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR3

<400> 37
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
1               5                   10                  15      
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30      

<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 38
His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   

<210> 39
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR4

<400> 39
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 40
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> HCVR

<400> 40
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 41
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR1

<400> 41
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys 
            20              

<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 42
Lys Ser Ser Gln Ser Leu Phe Tyr Ser Thr Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 43
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR2

<400> 43
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 44
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 45
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR3

<400> 45
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 46
Gln Gln Tyr Tyr Tyr Phe Pro Tyr Thr 
1               5                   

<210> 47
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR4

<400> 47
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  

<210> 48
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> LCVR

<400> 48
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          
Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Tyr Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 49
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR1

<400> 49
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210> 50
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 50
Gly Tyr Thr Phe Thr Asp Tyr Thr Ile His 
1               5                   10  

<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR2

<400> 51
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 52
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 52
Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly Arg 
        

<210> 53
<211> 31
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR3

<400> 53
Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
1               5                   10                  15      
Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30      

<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 54
His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   

<210> 55
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR4

<400> 55
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 56
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> HCVR

<400> 56
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Phe Tyr Pro Gly Ser His Ser Ile Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 57
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR1

<400> 57
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys 
            20              

<210> 58
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 58
Lys Ser Ser Gln Ser Leu Phe Tyr Ser Thr Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 59
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR2

<400> 59
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 60
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 61
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR3

<400> 61
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 62
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 62
Gln Gln Tyr Tyr Tyr Phe Pro Tyr Thr 
1               5                   

<210> 63
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR4

<400> 63
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  

<210> 64
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> LCVR

<400> 64
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Tyr Ser 
            20                  25                  30          
Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Tyr Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 65
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR1

<400> 65
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210> 66
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 66
Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His 
1               5                   10  

<210> 67
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR2

<400> 67
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 68
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 68
Trp Phe Tyr Pro Gly Ser Gly Ser Thr Glu Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 69
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR3

<400> 69
Arg Val Thr Met Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys Glu Arg 
            20                  25                  30          



<210> 70
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 70
His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   

<210> 71
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR4

<400> 71
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 72
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> HCVR

<400> 72
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Phe Tyr Pro Gly Ser Gly Ser Thr Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Glu Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Val Thr Val Ser Ser 
        115             

<210> 73
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR1

<400> 73
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys 
            20              

<210> 74
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 74
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 75
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR2

<400> 75
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 76
Trp Ala Ser Thr Arg Gly Ser 
1               5           

<210> 77
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR3

<400> 77
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 78
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 78
Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr 
1               5                   

<210> 79
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR4

<400> 79
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 80
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> LCVR

<400> 80
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys 
    

<210> 81
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR1

<400> 81
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210> 82
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 82
Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His 
1               5                   10  

<210> 83
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR2

<400> 83
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 84
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 84
Trp Phe Tyr Pro Gly Ser Gly Ser Ala Glu Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 85
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR3

<400> 85
Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Glu Arg 
            20                  25                  30          



<210> 86
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 86
His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   

<210> 87
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR4

<400> 87
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 88
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> HCVR

<400> 88
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Phe Tyr Pro Gly Ser Gly Ser Ala Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Glu Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Val Thr Val Ser Ser 
        115             

<210> 89
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR1

<400> 89
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys 
            20              

<210> 90
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 90
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 91
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR2

<400> 91
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 92
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 92
Trp Ala Ser Thr Arg Gly Ser 
1               5           

<210> 93
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR3

<400> 93
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 94
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 94
Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr 
1               5                   

<210> 95
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR4

<400> 95
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 96
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> LCVR

<400> 96
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys 
    

<210> 97
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR1

<400> 97
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  

<210> 98
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 98
Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His 
1               5                   10  

<210> 99
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR2

<400> 99
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 100
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 100
Trp Phe Tyr Pro Gly Ser Gly Ser Thr Glu Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 101
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR3

<400> 101
Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Glu Arg 
            20                  25                  30          



<210> 102
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 102
His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   

<210> 103
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR4

<400> 103
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 104
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> HCVR

<400> 104
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          
Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Phe Tyr Pro Gly Ser Gly Ser Thr Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Glu Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Val Thr Val Ser Ser 
        115             

<210> 105
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR1

<400> 105
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys 
            20              

<210> 106
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 106
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 107
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR2

<400> 107
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 108
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 108
Trp Ala Ser Thr Arg Gly Ser 
1               5           

<210> 109
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR3

<400> 109
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 110
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 110
Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr 
1               5                   

<210> 111
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR4

<400> 111
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 112
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> LCVR

<400> 112
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys 
    

<210> 113
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR1

<400> 113
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser 
            20                  25  

<210> 114
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR1

<400> 114
Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His 
1               5                   10  

<210> 115
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR2

<400> 115
Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 116
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR2

<400> 116
Trp Phe Tyr Pro Gly Ser Gly Ser Thr Glu Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 117
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR3

<400> 117
Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      
Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Glu Arg 
            20                  25                  30          



<210> 118
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH-CDR3

<400> 118
His Gly Gly Tyr Asp Gly Phe Asp Tyr 
1               5                   

<210> 119
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> HFR4

<400> 119
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 120
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> HCVR

<400> 120
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          
Thr Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Phe Tyr Pro Gly Ser Gly Ser Thr Glu Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Glu Arg His Gly Gly Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Val Thr Val Ser Ser 
        115             

<210> 121
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR1

<400> 121
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys 
            20              

<210> 122
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR1

<400> 122
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Asn Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 123
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR2

<400> 123
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 124
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR2

<400> 124
Trp Ala Ser Thr Arg Gly Ser 
1               5           

<210> 125
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR3

<400> 125
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 126
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL-CDR3

<400> 126
Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr 
1               5                   

<210> 127
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> LFR4

<400> 127
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 128
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> LCVR

<400> 128
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          
Asn Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         
Lys 
    

