                         SEQUENCE LISTING

<110>  The University of Queensland
 
<120>  Self-assembling, self-adjuvanting system for delivery of vaccines

<130>  32996PCT

<150>  AU 2020900058
<151>  2020-01-09

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polyleucine hydrophobic peptide.

<400>  1

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic 15 polyleucine hydrophobic peptide.

<400>  2

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic valine hydrophobic peptide.

<400>  3

Val Val Val Val Val Val Val Val Val Val 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic phenylalanine hydrophobic peptide.

<400>  4

Phe Phe Phe Phe Phe Phe Phe Phe Phe Phe 
1               5                   10  


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic hydrophilic polylysine and polyserine carrier or 
       linker.

<400>  5

Lys Lys Lys Lys Ser Ser 
1               5       


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic hydrophilic polylysine and serine carrier or linker.

<400>  6

Ser Lys Lys Lys Lys 
1               5   


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Pan-DR-helper cell epitope, PADRE.

<400>  7

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic T helper epitope, P25.

<400>  8

Lys Leu Ile Pro Asn Ala Ser Leu Ile Glu Asn Cys Thr Lys Ala Glu 
1               5                   10                  15      


Leu 
    


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J8, a synthetic epitope derived from amino acids 344-355 of the M
       protein of M1 GAS strain, flanked with GCN4 DNA-binding protein 
       sequences.

<400>  9

Gln Ala Glu Asp Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val 
1               5                   10                  15      


Glu Lys Ala Leu Lys Gln Leu Glu Asp Lys Val Gln 
            20                  25              


<210>  10
<211>  19
<212>  PRT
<213>  group A streptococcus

<400>  10

Glu Val Leu Thr Arg Arg Gln Ser Gln Asp Pro Lys Tyr Val Thr Gln 
1               5                   10                  15      


Arg Ile Ser 
            


<210>  11
<211>  20
<212>  PRT
<213>  group A streptococcus

<400>  11

Asp Asn Gly Lys Ala Ile Tyr Glu Arg Ala Arg Glu Arg Ala Leu Gln 
1               5                   10                  15      


Glu Leu Gly Pro 
            20  


<210>  12
<211>  22
<212>  PRT
<213>  Necator americanus

<400>  12

Thr Ser Leu Ile Ala Gly Pro Lys Ala Gln Val Glu Ala Ile Gln Lys 
1               5                   10                  15      


Tyr Ile Gly Ala Glu Leu 
            20          


<210>  13
<211>  9
<212>  PRT
<213>  Human papillomavirus type 16

<400>  13

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  14
<211>  14
<212>  PRT
<213>  Human papillomavirus type 16

<400>  14

Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   10                  


<210>  15
<211>  17
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  15

Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  40
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  16

Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
1               5                   10                  15      


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            20                  25                  30          


Asn Gly Val Gly Tyr Gln Pro Tyr 
        35                  40  


<210>  17
<211>  39
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  17

Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
1               5                   10                  15      


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
            20                  25                  30          


Ser Thr Pro Cys Asn Gly Val 
        35                  


<210>  18
<211>  14
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  18

Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
1               5                   10                  


<210>  19
<211>  30
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  19

Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
1               5                   10                  15      


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
            20                  25                  30  


<210>  20
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide incorporating J8, lysine and PADRE.

<400>  20

Gln Ala Glu Asp Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val 
1               5                   10                  15      


Glu Lys Ala Leu Lys Gln Leu Glu Asp Lys Val Gln Lys Ala Lys Phe 
            20                  25                  30          


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
        35                  40          


<210>  21
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide incorporating PADRE and J8.

<400>  21

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu 
1               5                   10                  15      


Asp Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala 
            20                  25                  30          


Leu Lys Gln Leu Glu Asp Lys Val Gln 
        35                  40      


<210>  22
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide incorporating PADRE and PL1.

<400>  22

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Glu Val Leu 
1               5                   10                  15      


Thr Arg Arg Gln Ser Gln Asp Pro Lys Tyr Val Thr Gln Arg Ile Ser 
            20                  25                  30          


<210>  23
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide incorporating PADRE and 88/30.

<400>  23

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Asp Asn Gly 
1               5                   10                  15      


Lys Ala Ile Tyr Glu Arg Ala Arg Glu Arg Ala Leu Gln Glu Leu Gly 
            20                  25                  30          


Pro 
    


<210>  24
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide incorporating p3, lysine and P25.

<400>  24

Thr Ser Leu Ile Ala Gly Pro Lys Ala Gln Val Glu Ala Ile Gln Lys 
1               5                   10                  15      


Tyr Ile Gly Ala Glu Leu Lys Lys Leu Ile Pro Asn Ala Ser Leu Ile 
            20                  25                  30          


Glu Asn Cys Thr Lys Ala Glu Leu 
        35                  40  


<210>  25
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent, Compound Leu-8Qm, incorporating polyleucine 
       hydrophobic peptide and 8Qm.

<400>  25

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Gln Ala Glu Pro Asp Arg 
1               5                   10                  15      


Ala His Tyr Asn Ile Val Thr Phe 
            20                  


<210>  26
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyleucine hydrophobic peptide, 
       PADRE and J8.

<400>  26

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Lys Phe Val Ala Ala 
1               5                   10                  15      


Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu Asp Lys Val Lys Gln Ser 
            20                  25                  30          


Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Lys Gln Leu Glu Asp 
        35                  40                  45              


Lys Val Gln 
    50      


<210>  27
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyleucine hydrophobic peptide, 
       PADRE and PL1.

<400>  27

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Lys Phe Val Ala Ala 
1               5                   10                  15      


Trp Thr Leu Lys Ala Ala Ala Glu Val Leu Thr Arg Arg Gln Ser Gln 
            20                  25                  30          


Asp Pro Lys Tyr Val Thr Gln Arg Ile Ser 
        35                  40          


<210>  28
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyleucine hydrophobic peptide, 
       PADRE and 88/30.

<400>  28

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Lys Phe Val Ala Ala 
1               5                   10                  15      


Trp Thr Leu Lys Ala Ala Ala Asp Asn Gly Lys Ala Ile Tyr Glu Arg 
            20                  25                  30          


Ala Arg Glu Arg Ala Leu Gln Glu Leu Gly Pro 
        35                  40              


<210>  29
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyleucine hydrophobic peptide, 
       PADRE, lysine and J8.

<400>  29

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Lys Gln Ala Glu 
            20                  25                  30          


Asp Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala 
        35                  40                  45              


Leu Lys Gln Leu Glu Asp Lys Val Gln 
    50                  55          


<210>  30
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyleucine hydrophobic peptide, 
       J8, lysine and PADRE.

<400>  30

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Ala Glu Asp Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu 
            20                  25                  30          


Lys Ala Leu Lys Gln Leu Glu Asp Lys Val Gln Lys Ala Lys Phe Val 
        35                  40                  45              


Ala Ala Trp Thr Leu Lys Ala Ala Ala 
    50                  55          


<210>  31
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating 15 polyleucine hydrophobic 
       peptide, PADRE and J8.

<400>  31

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu Asp 
            20                  25                  30          


Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu 
        35                  40                  45              


Lys Gln Leu Glu Asp Lys Val Gln 
    50                  55      


<210>  32
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyglutamine hydrophobic 
       peptide, PADRE and J8.

<400>  32

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala 
1               5                   10                  15      


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu Asp 
            20                  25                  30          


Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu 
        35                  40                  45              


Lys Gln Leu Glu Asp Lys Val Gln 
    50                  55      


<210>  33
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyglycine hydrophobic peptide, 
       PADRE and J8.

<400>  33

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala 
1               5                   10                  15      


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu Asp 
            20                  25                  30          


Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu 
        35                  40                  45              


Lys Gln Leu Glu Asp Lys Val Gln 
    50                  55      


<210>  34
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyserine hydrophobic peptide, 
       PADRE and J8.

<400>  34

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala 
1               5                   10                  15      


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu Asp 
            20                  25                  30          


Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu 
        35                  40                  45              


Lys Gln Leu Glu Asp Lys Val Gln 
    50                  55      


<210>  35
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating polyproline hydrophobic peptide, 
       PADRE and J8.

<400>  35

Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala 
1               5                   10                  15      


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu Asp 
            20                  25                  30          


Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu 
        35                  40                  45              


Lys Gln Leu Glu Asp Lys Val Gln 
    50                  55      


<210>  36
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating alanine hydrophobic peptide, 
       PADRE and J8.

<400>  36

Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu Asp 
            20                  25                  30          


Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu 
        35                  40                  45              


Lys Gln Leu Glu Asp Lys Val Gln 
    50                  55      


<210>  37
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent incorporating phenylalanine-leucine-alanine 
       repeat hydrophobic peptide, PADRE and J8.

<400>  37

Phe Leu Ala Phe Leu Ala Phe Leu Ala Phe Leu Ala Phe Leu Ala Ala 
1               5                   10                  15      


Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala Gln Ala Glu Asp 
            20                  25                  30          


Lys Val Lys Gln Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu 
        35                  40                  45              


Lys Gln Leu Glu Asp Lys Val Gln 
    50                  55      


<210>  38
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent, (Leu)10-B3, incorporating B3.

<400>  38

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Gly Val Gly Gly Asn Tyr 
1               5                   10                  15      


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
            20                  25                  30          


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
        35                  40                  45              


Gly Val 
    50  


<210>  39
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immunogenic agent, (Leu)10-PADRE, incorporating PADRE.

<400>  39

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Lys Phe Val Ala Ala 
1               5                   10                  15      


Trp Thr Leu Lys Ala Ala Ala 
            20              


<210>  40
<211>  20
<212>  PRT
<213>  group A streptococcus

<400>  40

Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu 
1               5                   10                  15      


Lys Ala Leu Glu 
            20  


