                         б

<110>  ż򣨱Ƽ޹˾
 
<120>  һUsherۺķ

<130>  FD00311PCT

<150>  PCT/CN2019/129957
<151>  2019-12-30

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  1728
<212>  DNA
<213>  ˹

<220>
<223>  USH2Aϵͳ

<400>  1
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaaggc cacgaacttc      720

tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcctgctag cgcccttgaa      780

tttatggatg aaggagacac cctgaggcct ttcacactct acgaatatcg ggtcagagcc      840

tgtaactcca agggttcagt ggagagtctg tggtcattaa cacaaactct ggaagctcca      900

cctcaagatt ttccagctcc ttgggctcaa gccacgagtg ctcattcagt tctgttgaat      960

tggacaaagc cagcggccgc tgagggcaga ggaagtcttc taacatgcgg tgacgtggag     1020

gagaatcccg gcccttccgg aatggagagc gacgagagcg gcctgcccgc catggagatc     1080

gagtgccgca tcaccggcac cctgaacggc gtggagttcg agctggtggg cggcggagag     1140

ggcaccccca agcagggccg catgaccaac aagatgaaga gcaccaaagg cgccctgacc     1200

ttcagcccct acctgctgag ccacgtgatg ggctacggct tctaccactt cggcacctac     1260

cccagcggct acgagaaccc cttcctgcac gccatcaaca acggcggcta caccaacacc     1320

cgcatcgaga agtacgagga cggcggcgtg ctgcacgtga gcttcagcta ccgctacgag     1380

gccggccgcg tgatcggcga cttcaaggtg gtgggcaccg gcttccccga ggacagcgtg     1440

atcttcaccg acaagatcat ccgcagcaac gccaccgtgg agcacctgca ccccatgggc     1500

gataacgtgc tggtgggcag cttcgcccgc accttcagcc tgcgcgacgg cggctactac     1560

agcttcgtgg tggacagcca catgcacttc aagagcgcca tccaccccag catcctgcag     1620

aacgggggcc ccatgttcgc cttccgccgc gtggaggagc tgcacagcaa caccgagctg     1680

ggcatcgtgg agtaccagca cgccttcaag acccccatcg ccttcgcc                  1728


<210>  2
<211>  111
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  2
agcccaagga gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag       60

acucuccacu gaacccuugg aguuacaggc ucugacccga uauucguaga g               111


<210>  3
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  3
gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag acucuccacu       60

gaacccuugg aguuacaggc ucugacccga u                                      91


<210>  4
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  4
cuugaggugg agcuuccaga guuuguguua augaccacag acucuccacu gaacccuugg       60

aguuacaggc u                                                            71


<210>  5
<211>  51
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  5
agcuuccaga guuuguguua augaccacag acucuccacu gaacccuugg a                51


<210>  6
<211>  101
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  6
agcccaagga gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag       60

acucuccacu gaacccuugg aguuacaggc ucugacccga u                          101


<210>  7
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  7
agcccaagga gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag       60

acucuccacu gaacccuugg aguuacaggc u                                      91


<210>  8
<211>  81
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  8
agcccaagga gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag       60

acucuccacu gaacccuugg a                                                 81


<210>  9
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  9
agcccaagga gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag       60

acucuccacu g                                                            71


<210>  10
<211>  61
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  10
agcccaagga gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag       60

a                                                                       61


<210>  11
<211>  101
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  11
gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag acucuccacu       60

gaacccuugg aguuacaggc ucugacccga uauucguaga g                          101


<210>  12
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  12
cuugaggugg agcuuccaga guuuguguua augaccacag acucuccacu gaacccuugg       60

aguuacaggc ucugacccga uauucguaga g                                      91


<210>  13
<211>  81
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  13
agcuuccaga guuuguguua augaccacag acucuccacu gaacccuugg aguuacaggc       60

ucugacccga uauucguaga g                                                 81


<210>  14
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  14
guuuguguua augaccacag acucuccacu gaacccuugg aguuacaggc ucugacccga       60

uauucguaga g                                                            71


<210>  15
<211>  61
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  15
augaccacag acucuccacu gaacccuugg aguuacaggc ucugacccga uauucguaga       60

g                                                                       61


<210>  16
<211>  5332
<212>  DNA
<213>  ˹

<220>
<223>  arRNAAAV

<400>  16
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccattc ggtacaattc acgcgtgagg gcctatttcc catgattcct      180

tcatatttgc atatacgata caaggctgtt agagagataa ttggaattaa tttgactgta      240

aacacaaaga tattagtaca aaatacgtga cgtagaaagt aataatttct tgggtagttt      300

gcagttttaa aattatgttt taaaatggac tatcatatgc ttaccgtaac ttgaaagtat      360

ttcgatttct tggctttata tatcttgtgg aaaggacgaa acaccgccac tgcagcagca      420

aagcccggcc cttttctctc tgctccactg tgaagttcat cagtccgctt ggggcagatt      480

ccaaagtctt aatcagggtc caggggctcg acacctttcc tgcactgttt acagccacca      540

caccaatgtg gtatgttttt ttttttggta ccaggtcttg aaaggagtgg gcgcgtgtcg      600

acattgatta ttgactagct ctggtcgtta cataacttac ggtaaatggc ccgcctggct      660

gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc      720

caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg      780

cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat      840

ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca      900

tctactcgag gccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat      960

tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg     1020

gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg aggcggagag     1080

gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc     1140

ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc gggagcggga tcagccaccg     1200

cggtggcggc cctagagtcg atcgaggaac tgaaaaacca gaaagttaac tggtaagttt     1260

agtctttttg tcttttattt caggtcccgg atccggtggt ggtgcaaatc aaagaactgc     1320

tcctcagtgg atgttgcctt tacttctagg cctgtacgga agtgttactt ctgctctaaa     1380

agctgcggaa ttgtacccgc ggccgatcca ccggtcgcca ccatggtgag caagggcgag     1440

gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac     1500

aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag     1560

ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc     1620

tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag     1680

tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac     1740

tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg     1800

aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac     1860

aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc     1920

aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac     1980

acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc     2040

gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc     2100

gccgccggga tcactctcgg catggacgag ctgtacaagt aaatcgaatt ccgctcgaga     2160

taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc     2220

tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg     2280

tatggctttc attttctcct ccttgtataa atcctggtta gttcttgcca cggcggaact     2340

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     2400

cgtggtgttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca tctagcttta     2460

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     2520

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggagatg tgggaggttt     2580

tttaaagcgg ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     2640

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     2700

ctcagtgagc gagcgagcgc gcagctgcct gcaggggcgc ctgatgcggt attttctcct     2760

tacgcatctg tgcggtattt cacaccgcat acgtcaaagc aaccatagta cgcgccctgt     2820

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     2880

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     2940

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     3000

cacctcgacc ccaaaaaact tgatttgggt gatggttcac gtagtgggcc atcgccctga     3060

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     3120

caaactggaa caacactcaa ccctatctcg ggctattctt ttgatttata agggattttg     3180

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     3240

aacaaaatat taacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc     3300

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     3360

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     3420

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     3480

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     3540

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     3600

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     3660

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     3720

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     3780

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     3840

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     3900

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     3960

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     4020

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     4080

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     4140

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     4200

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     4260

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     4320

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     4380

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     4440

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     4500

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     4560

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     4620

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     4680

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     4740

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     4800

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     4860

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     4920

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     4980

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     5040

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     5100

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     5160

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     5220

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     5280

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gt             5332


<210>  17
<211>  76
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  17
aaggagcugg aaaaucuuga gguggagcuu ccagaguuug uguuaaugac cacagacucu       60

ccacugaacc cuugga                                                       76


<210>  18
<211>  71
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  18
gcuggaaaau cuugaggugg agcuuccaga guuuguguua augaccacag acucuccacu       60

gaacccuugg a                                                            71


<210>  19
<211>  66
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  19
aaaaucuuga gguggagcuu ccagaguuug uguuaaugac cacagacucu ccacugaacc       60

cuugga                                                                  66


<210>  20
<211>  61
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  20
cuugaggugg agcuuccaga guuuguguua augaccacag acucuccacu gaacccuugg       60

a                                                                       61


<210>  21
<211>  56
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  21
gguggagcuu ccagaguuug uguuaaugac cacagacucu ccacugaacc cuugga           56


<210>  22
<211>  42
<212>  DNA
<213>  ˹

<220>
<223>  PCR

<400>  22
ggagtgagta cggtgtgccc catctctttg gcttggaacc at                          42


<210>  23
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  23
aaggagcugg aaaaucuuga gguggagcuu ccagaguuug uguuaaugac cacagacucu       60

ccacugaacc cuuggaguua caggcucuga c                                      91


<210>  24
<211>  45
<212>  DNA
<213>  ˹

<220>
<223>  PCR

<400>  24
gagttggatg ctggatggct tttctctctg ctccactgtg aagtt                       45


<210>  25
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  25
gcuugagccc aaggagcugg aaaaucuuga gguggagcuu ccagaguuug uguuaaugac       60

cacagacucu ccacugaacc cuuggaguua c                                      91


<210>  26
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  26
ucguggcuug agcccaagga gcuggaaaau cuugaggugg agcuuccaga guuuguguua       60

augaccacag acucuccacu gaacccuugg a                                      91


<210>  27
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  27
agcacucgug gcuugagccc aaggagcugg aaaaucuuga gguggagcuu ccagaguuug       60

uguuaaugac cacagacucu ccacugaacc c                                      91


<210>  28
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  28
gaaugagcac ucguggcuug agcccaagga gcuggaaaau cuugaggugg agcuuccaga       60

guuuguguua augaccacag acucuccacu g                                      91


<210>  29
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  29
gaacugaaug agcacucgug gcuugagccc aaggagcugg aaaaucuuga gguggagcuu       60

ccagaguuug uguuaaugac cacagacucu c                                      91


<210>  30
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  30
caacagaacu gaaugagcac ucguggcuug agcccaagga gcuggaaaau cuugaggugg       60

agcuuccaga guuuguguua augaccacag a                                      91


<210>  31
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  31
caauucaaca gaacugaaug agcacucgug gcuugagccc aaggagcugg aaaaucuuga       60

gguggagcuu ccagaguuug uguuaaugac c                                      91


<210>  32
<211>  151
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  32
ccacugcagc agcaaagccc ggcccuuuuc ucucugcucc acugugaagu ucaucagucc       60

gcuuggggca gauuccaaag ucuuaaucag gguccagggg cucgacaccu uuccugcacu      120

guuuacagcc accacaccaa ugugguaugu u                                     151


<210>  33
<211>  41
<212>  DNA
<213>  ˹

<220>
<223>  PCR

<400>  33
ggagtgagta cggtgtgcgg aagaaaaccc cggtcctgct a                           41


<210>  34
<211>  43
<212>  DNA
<213>  ˹

<220>
<223>  PCR

<400>  34
gagttggatg ctggatggaa cagaactgaa tgagcactcg tgg                         43


<210>  35
<211>  91
<212>  RNA
<213>  ˹

<220>
<223>  arRNA

<400>  35
uaauccugaa uaucgcgcaa uuccccagca gagaacaucg cggugugaac gucccuuuau       60

accgggcagg uauagcugaa aucagcgugg c                                      91

