                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Cronce, Michael
       Cox, Jeffrey
       Keasling, Jay D
 
<120>  Methods and Compositions for Producing a Heterologous Antiviral 
       Compound in a Host Cell

<130>  2019-085-02

<140>  PCT/US 2020/066731
<141>  2020-12-22

<150>  US 62/953,074
<151>  2019-12-23

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  2
<211>  274
<212>  PRT
<213>  Selenomonas ruminantium

<400>  2

Met Ala Tyr Lys Val Asn Leu His Ile Thr Gln Lys Cys Asn Tyr Ala 
1               5                   10                  15      


Cys Lys Tyr Cys Phe Ala His Phe Asp His His Asn Asp Leu Thr Leu 
            20                  25                  30          


Gly Gln Trp Lys His Ile Ile Asp Asn Leu Lys Thr Ser Gly Leu Val 
        35                  40                  45              


Asp Ala Ile Asn Phe Ala Gly Gly Glu Pro Val Leu His Arg Asp Phe 
    50                  55                  60                  


Ala Ala Ile Val Asn Tyr Ala Tyr Asp Gln Gly Phe Lys Leu Ser Ile 
65                  70                  75                  80  


Ile Thr Asn Gly Ser Leu Met Leu Asn Pro Lys Leu Met Pro Pro Glu 
                85                  90                  95      


Leu Phe Ala Lys Phe Asp Thr Leu Gly Ile Ser Val Asp Ser Ile Asn 
            100                 105                 110         


Pro Lys Thr Leu Ile Ala Leu Gly Ala Cys Asn Asn Ser Gln Glu Val 
        115                 120                 125             


Leu Ser Tyr Asp Lys Leu Ser His Leu Ile Thr Leu Ala Arg Ser Val 
    130                 135                 140                 


Asn Pro Thr Ile Arg Ile Lys Leu Asn Thr Val Ile Thr Asn Leu Asn 
145                 150                 155                 160 


Ala Asp Glu Asp Leu Thr Ile Ile Gly Gln Glu Leu Asp Ile Ala Arg 
                165                 170                 175     


Trp Lys Met Leu Arg Met Lys Leu Phe Ile His Glu Gly Phe Asn Asn 
            180                 185                 190         


Ala Pro Leu Leu Val Ser Gln Ala Asp Phe Asp Gly Phe Val Glu Arg 
        195                 200                 205             


His Ala Glu Val Ser His Asp Ile Val Pro Glu Asn Asp Leu Thr Arg 
    210                 215                 220                 


Ser Tyr Ile Met Val Asp Asn Gln Gly Arg Leu Leu Asp Asp Glu Thr 
225                 230                 235                 240 


Glu Glu Tyr Lys Val Val Gly Ser Leu Leu Ala Glu Asp Phe Gly Thr 
                245                 250                 255     


Val Phe Asp Arg Tyr His Phe Asp Glu Ala Thr Tyr Ala Ser Arg Tyr 
            260                 265                 270         


Ala Gly 
        


<210>  3
<211>  298
<212>  PRT
<213>  Psychrobacter lutiphocae

<400>  3

Met His Asn His Asn Lys Ile Ala Asn Lys Glu Leu Val Val Asn Trp 
1               5                   10                  15      


His Ile Thr Glu Ala Cys Asn Tyr Arg Cys Gly Tyr Cys Phe Ala Lys 
            20                  25                  30          


Trp Gly Lys Gln Lys Gly Glu Leu Ile Gln Asp Val Ala Ser Ile Ser 
        35                  40                  45              


Gln Leu Met Asp Ala Ile Ser Gly Leu Pro Ala Val Leu Asn Gln Met 
    50                  55                  60                  


His Ala Ala Asn Phe Glu Gly Val Arg Leu Asn Leu Val Gly Gly Glu 
65                  70                  75                  80  


Thr Phe Leu Asn Tyr Arg Lys Ile Lys Glu Val Val Lys Gln Ala Lys 
                85                  90                  95      


Lys Arg Gly Leu Lys Leu Ser Ala Ile Thr Asn Gly Ser Arg Ile Asn 
            100                 105                 110         


Asn Asp Phe Ile Asn Leu Ile Ala Asn Asn Phe Ala Ser Ile Gly Phe 
        115                 120                 125             


Ser Val Asp Ser Val Asp Asn Ser Thr Asn Leu Asn Ile Gly Arg Val 
    130                 135                 140                 


Glu Lys Asn Ala Val Met Asn Pro Glu Lys Ile Ile His Thr Ile Ala 
145                 150                 155                 160 


Ser Ile Arg Ala Ile Asn Pro Lys Ile Glu Ile Lys Val Asn Thr Val 
                165                 170                 175     


Val Ser Asp Leu Asn Lys Ser Glu Asp Leu Ser Asp Phe Ile Gly Gln 
            180                 185                 190         


Val Met Pro Asn Lys Trp Lys Ile Phe Lys Val Leu Pro Val Val Ala 
        195                 200                 205             


Asn His His Leu Ile Ser Glu Glu Gln Phe Thr Arg Phe Leu Arg Arg 
    210                 215                 220                 


His Gln Arg Phe Gly Glu Ile Ile Tyr Ala Glu Asp Asn Thr Glu Met 
225                 230                 235                 240 


Val Asp Ser Tyr Ile Met Ile Asp Pro Ile Gly Arg Phe Phe Gln Asn 
                245                 250                 255     


Ser Asp Phe Asn Asn Gly Tyr Tyr Tyr Ser Arg Pro Ile Leu Gln Val 
            260                 265                 270         


Gly Ile His Gln Ala Phe Asn Glu Ile Asn Phe Asn Ala Asn Lys Phe 
        275                 280                 285             


Tyr Ser Arg Tyr Lys Arg Ala Ser Leu Asn 
    290                 295             


<210>  4
<211>  333
<212>  PRT
<213>  Fibrobacter sp. UWH6

<400>  4

Met Asn Ile Lys Thr Ile Val Ile Asn Trp His Ile Thr Glu Ser Cys 
1               5                   10                  15      


Asn Tyr Lys Cys Lys Tyr Cys Phe Ala Lys Trp Asn Arg Val Lys Glu 
            20                  25                  30          


Ile Trp Thr Asn Pro Asp Asn Val Arg Lys Ile Leu Glu Asn Leu Lys 
        35                  40                  45              


Ser Ile Arg Leu Glu Asp Cys Leu Phe Thr Gln Lys Arg Leu Asn Ile 
    50                  55                  60                  


Val Gly Gly Glu Pro Ile Leu Gln Gln Glu Arg Leu Trp Gln Val Ile 
65                  70                  75                  80  


Lys Met Ala His Glu Met Asp Phe Glu Ile Ser Ile Ile Thr Asn Gly 
                85                  90                  95      


Ser His Leu Glu Tyr Ile Cys Pro Phe Val His Leu Ile Ser Gln Val 
            100                 105                 110         


Gly Val Ser Ile Asp Ser Phe Asp His Lys Thr Asn Val Arg Ile Gly 
        115                 120                 125             


Arg Glu Cys Asn Gly Lys Thr Ile Ser Phe Gln Gln Leu Lys Glu Lys 
    130                 135                 140                 


Leu Glu Glu Leu Arg Thr Leu Asn Pro Gly Leu Asn Ile Lys Ile Asn 
145                 150                 155                 160 


Thr Val Val Asn Glu Tyr Asn Phe Asn Glu Ile Leu Val Asp Arg Met 
                165                 170                 175     


Ala Glu Leu Lys Ile Asp Lys Trp Lys Ile Leu Arg Gln Leu Pro Phe 
            180                 185                 190         


Asp Gly Lys Glu Gly Ile Ser Asp Phe Lys Phe Asn Thr Phe Leu Phe 
        195                 200                 205             


Asn Asn Leu Lys Glu Glu Lys Met Pro Lys Lys Asp Pro Leu Ser Asn 
    210                 215                 220                 


Phe Leu Ala Ala Phe Ser Ala Pro Gln Lys Gln Asn Asn Val Ile Phe 
225                 230                 235                 240 


Val Glu Asp Asn Asp Val Met Thr Glu Ser Tyr Leu Met Ile Ala Pro 
                245                 250                 255     


Asp Gly Arg Leu Phe Gln Asn Gly His Lys Glu Tyr Glu Tyr Ser His 
            260                 265                 270         


Pro Leu Thr Glu Ile Ser Ile Asp Glu Ala Leu Glu Glu Ile Asn Phe 
        275                 280                 285             


Asp Gln Glu Lys Phe Asn Asn Arg Tyr Glu Asn Tyr Ala Thr Glu Glu 
    290                 295                 300                 


Ala Lys Tyr Arg Met Glu Glu Phe Phe Leu Met Asn Glu Tyr Glu Asp 
305                 310                 315                 320 


Val Ser Phe Asp Cys Cys Cys Pro Phe Gly Asp Lys Asp 
                325                 330             


<210>  5
<211>  308
<212>  PRT
<213>  Fibrobacter sp. UWH6

<400>  5

Met Glu Ile His Met Thr Ser Ile Gln Glu Leu Val Ile Asn Phe His 
1               5                   10                  15      


Met Thr Glu Ala Cys Asn Tyr Arg Cys Gly Tyr Cys Tyr Ala Thr Trp 
            20                  25                  30          


Gln Asp Asn Ser Ser Asp Thr Glu Leu His His Ala Ser Glu Asn Ile 
        35                  40                  45              


His Ser Leu Leu Leu Lys Leu Ala Asp Tyr Phe Phe Ala Asp Asn Ser 
    50                  55                  60                  


Leu Arg Gln Thr Leu Lys Tyr Gln Ser Val Arg Ile Asn Phe Ala Gly 
65                  70                  75                  80  


Gly Glu Pro Val Met Leu Gly Ser Arg Phe Ile Asp Ala Ile Leu Phe 
                85                  90                  95      


Ala Lys Gln Leu Gly Phe Ala Thr Ser Ile Ile Thr Asn Gly His Leu 
            100                 105                 110         


Leu Ser Thr Val Met Leu Lys Lys Ile Ala Val His Leu Asp Met Leu 
        115                 120                 125             


Gly Ile Ser Phe Asp Thr Gly Asp Tyr Leu Ile Ala Gln Ser Ile Gly 
    130                 135                 140                 


Arg Val Asp Arg Lys Lys Ser Trp Leu Ser Pro Ala Arg Val Leu Asp 
145                 150                 155                 160 


Val Val Thr Gln Tyr Arg Ala Leu Asn Pro Lys Gly Lys Val Lys Ile 
                165                 170                 175     


Asn Thr Val Val Asn Ala Tyr Asn Trp Arg Glu Asn Leu Thr Gln Thr 
            180                 185                 190         


Ile Thr Gln Leu Lys Pro Asp Lys Trp Lys Leu Leu Arg Val Leu Pro 
        195                 200                 205             


Val Tyr Ser Lys Glu Met Thr Val Leu Gln Trp Gln Tyr Glu Ser Tyr 
    210                 215                 220                 


Val His Lys His Gln Val His Ala Asp Val Ile Val Val Glu Asp Asn 
225                 230                 235                 240 


Asp Asp Met Trp Gln Ser Tyr Leu Met Ile Asn Pro Glu Gly Arg Phe 
                245                 250                 255     


Tyr Gln Asn Ala Gly Ala Cys Lys Gly Leu Thr Tyr Ser Pro Pro Val 
            260                 265                 270         


Leu Glu Val Gly Val Glu Glu Ala Leu Lys Tyr Ile Asn Phe Asn Ala 
        275                 280                 285             


Glu Ala Phe Ser Lys Arg Tyr Gln Ser Ile His Leu Pro Leu Ala Met 
    290                 295                 300                 


Ser Ala Gly Ala 
305             


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Cys Xaa Xaa Xaa Cys Xaa Xaa Cys 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Cys Asn Tyr Xaa Cys Xaa Xaa Cys 
1               5               


