                         SEQUENCE LISTING

<110>  JOSLIN DIABETES CENTER
 
<120>  MONOAMINE OXIDASE INHIBITORS AS MODIFIERS OF BETA CELL 
       VULNERABILITY IN TYPE 1 DIABETES

<130>  01123-0011-00PCT

<150>  US 62/952,538
<151>  2019-12-23

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  1

Cys Thr Ala Cys Thr Cys Cys Thr Cys Thr Cys Gly Cys Thr Ala Thr 
1               5                   10                  15      


Gly Cys Thr Cys 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-targeting gRNA

<400>  2

Thr Ala Ala Ala Ala Ala Cys Gly Cys Thr Gly Gly Cys Gly Gly Cys 
1               5                   10                  15      


Cys Thr Ala Gly 
            20  


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Rnls gRNA targeting sequence

<400>  3

Thr Thr Ala Thr Ala Gly Thr Ala Gly Cys Cys Gly Gly Thr Ala Cys 
1               5                   10                  15      


Gly Cys Ala 
            


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls gRNA sequence for exon 2-4

<400>  4

Cys Gly Thr Cys Thr Gly Gly Gly Ala Ala Gly Thr Cys Thr Thr Gly 
1               5                   10                  15      


Gly Thr Cys Gly 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls gRNA sequence for exon 2-4

<400>  5

Cys Gly Gly Gly Ala Cys Thr Cys Ala Thr Cys Cys Cys Ala Thr Thr 
1               5                   10                  15      


Gly Thr Cys Gly 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls gRNA sequence for exon 5

<400>  6

Gly Gly Gly Gly Ala Gly Thr Gly Ala Gly Gly Ala Thr Ala Gly Gly 
1               5                   10                  15      


Ala Thr Ala Gly 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls gRNA sequence for exon 5

<400>  7

Thr Cys Cys Gly Thr Ala Gly Thr Gly Gly Thr Thr Thr Thr Ala Gly 
1               5                   10                  15      


Ala Gly Thr Gly 
            20  


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chop forward primer

<400>  8

Cys Cys Ala Cys Cys Ala Cys Ala Cys Cys Thr Gly Ala Ala Ala Gly 
1               5                   10                  15      


Cys Ala Gly Ala Ala 
            20      


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chop reverse primer

<400>  9

Ala Gly Gly Thr Gly Ala Ala Ala Gly Gly Cys Ala Gly Gly Gly Ala 
1               5                   10                  15      


Cys Thr Cys Ala 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Txnip forward primer

<400>  10

Thr Cys Ala Ala Gly Gly Gly Cys Cys Cys Thr Gly Gly Gly Ala Ala 
1               5                   10                  15      


Cys Ala Thr Cys 
            20  


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Txnip reverse primer

<400>  11

Gly Ala Cys Ala Cys Thr Gly Gly Thr Gly Cys Cys Ala Thr Thr Ala 
1               5                   10                  15      


Ala Gly Thr Cys Ala Gly 
            20          


<210>  12
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xbp1 forward primer

<400>  12

Ala Ala Ala Cys Ala Gly Ala Gly Thr Ala Gly Cys Ala Gly Cys Gly 
1               5                   10                  15      


Cys Ala Gly Ala Cys Thr Gly Cys 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xbp1 reverse primer

<400>  13

Thr Cys Cys Thr Thr Cys Thr Gly Gly Gly Thr Ala Gly Ala Cys Cys 
1               5                   10                  15      


Thr Cys Thr Gly Gly Gly Ala Gly 
            20                  


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Forward primer for Rnls gRNA site PCR

<400>  14

Thr Gly Cys Thr Ala Thr Ala Gly Ala Cys Ala Gly Thr Thr Gly Gly 
1               5                   10                  15      


Gly Ala Cys Thr Thr Gly Thr Thr Thr 
            20                  25  


<210>  15
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Reverse primer for Rnls gRNA site PCR

<400>  15

Ala Thr Ala Thr Thr Gly Cys Gly Thr Thr Cys Thr Ala Thr Thr Ala 
1               5                   10                  15      


Thr Cys Ala Ala Thr Gly Gly Ala Gly Ala Thr Gly Ala Ala Gly Cys 
            20                  25                  30          


<210>  16
<211>  59
<212>  PRT
<213>  Mus musculus

<400>  16

Cys Thr Gly Thr Gly Ala Gly Cys Thr Ala Cys Thr Cys Cys Thr Cys 
1               5                   10                  15      


Thr Cys Gly Cys Thr Ala Thr Gly Cys Thr Cys Thr Gly Gly Gly Cys 
            20                  25                  30          


Cys Thr Cys Thr Thr Thr Thr Ala Thr Gly Ala Ala Gly Thr Ala Gly 
        35                  40                  45              


Gly Cys Ala Thr Gly Ala Ala Gly Ala Thr Thr 
    50                  55                  


<210>  17
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls mutant 1

<400>  17

Cys Thr Gly Thr Gly Ala Gly Cys Thr Ala Cys Thr Cys Cys Thr Cys 
1               5                   10                  15      


Thr Cys Gly Cys Thr Cys Thr Gly Gly Gly Cys Cys Thr Cys Thr Thr 
            20                  25                  30          


Thr Thr Ala Thr Gly Ala Ala Gly Thr Ala Gly Gly Cys Ala Thr Gly 
        35                  40                  45              


Ala Ala Gly Ala Thr Thr 
    50                  


<210>  18
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls mutant 2

<400>  18

Cys Thr Gly Thr Gly Ala Gly Cys Thr Ala Cys Thr Cys Cys Thr Cys 
1               5                   10                  15      


Thr Cys Gly Cys Thr Ala Thr Cys Thr Cys Thr Gly Gly Gly Cys Cys 
            20                  25                  30          


Thr Cys Thr Thr Thr Thr Ala Thr Gly Ala Ala Gly Thr Ala Gly Gly 
        35                  40                  45              


Cys Ala Thr Gly Ala Ala Gly Ala Thr Thr 
    50                  55              


<210>  19
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls mutant 3

<400>  19

Cys Thr Gly Thr Gly Ala Gly Cys Thr Ala Cys Thr Cys Cys Thr Cys 
1               5                   10                  15      


Thr Cys Thr Gly Gly Gly Cys Cys Thr Cys Thr Thr Thr Thr Ala Thr 
            20                  25                  30          


Gly Ala Ala Gly Thr Ala Gly Gly Cys Ala Thr Gly Ala Ala Gly Ala 
        35                  40                  45              


Thr Thr 
    50  


<210>  20
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls mutant 4

<400>  20

Cys Thr Gly Thr Gly Ala Gly Cys Thr Ala Cys Thr Cys Cys Thr Cys 
1               5                   10                  15      


Thr Cys Gly Cys Thr Ala Thr Gly Gly Cys Thr Cys Thr Gly Gly Gly 
            20                  25                  30          


Cys Cys Thr Cys Thr Thr Thr Thr Ala Thr Gly Ala Ala Gly Thr Ala 
        35                  40                  45              


Gly Gly Cys Ala Thr Gly Ala Ala Gly Ala Thr Thr 
    50                  55                  60  


<210>  21
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls mutant 5

<400>  21

Cys Thr Gly Thr Gly Ala Gly Cys Thr Ala Cys Thr Cys Cys Thr Cys 
1               5                   10                  15      


Thr Cys Gly Cys Thr Gly Gly Gly Cys Cys Thr Cys Thr Thr Thr Thr 
            20                  25                  30          


Ala Thr Gly Ala Ala Gly Thr Ala Gly Gly Cys Ala Thr Gly Ala Ala 
        35                  40                  45              


Gly Ala Thr Thr 
    50          


<210>  22
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls mutant 6

<400>  22

Cys Thr Gly Thr Gly Ala Gly Cys Thr Ala Cys Thr Cys Cys Thr Cys 
1               5                   10                  15      


Thr Gly Gly Gly Cys Cys Thr Cys Thr Thr Thr Thr Ala Thr Gly Ala 
            20                  25                  30          


Ala Gly Thr Ala Gly Gly Cys Ala Thr Gly Ala Ala Gly Ala Thr Thr 
        35                  40                  45              


<210>  23
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rnls mutant 7

<400>  23

Cys Thr Gly Thr Gly Ala Gly Cys Thr Ala Cys Thr Cys Cys Thr Cys 
1               5                   10                  15      


Thr Cys Gly Cys Cys Thr Cys Thr Thr Thr Thr Ala Thr Gly Ala Ala 
            20                  25                  30          


Gly Thr Ala Gly Gly Cys Ala Thr Gly Ala Ala Gly Ala Thr Thr 
        35                  40                  45          


