                         SEQUENCE LISTING

<110>  GENENTECH, INC.
       SCALES, Suzanna Jane, et al.
 
<120>  APOLIPOPROTEIN L1-SPECIFIC ANTIBODIES AND METHODS OF USE

<130>  01164-0003-00PCT

<150>  US 62/953,097
<151>  2019-12-23

<160>  220   

<170>  PatentIn version 3.5

<210>  1
<211>  398
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(398)
<223>  Human APOL1 (with leader sequence)  G0 form EMR variant Accession
       no. NP003652

<400>  1

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
                165                 170                 175     


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
            180                 185                 190         


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
    210                 215                 220                 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
225                 230                 235                 240 


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
                245                 250                 255     


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
            260                 265                 270         


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
        275                 280                 285             


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
    290                 295                 300                 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
305                 310                 315                 320 


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
                325                 330                 335     


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
            340                 345                 350         


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
        355                 360                 365             


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
    370                 375                 380                 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
385                 390                 395             


<210>  2
<211>  370
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(370)
<223>  Human APOL1 without leader sequence  G0 form EMR variant  
       NP003652

<400>  2

Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr 
1               5                   10                  15      


Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met 
            20                  25                  30          


Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys 
        35                  40                  45              


Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu 
    50                  55                  60                  


Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala 
65                  70                  75                  80  


Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met 
                85                  90                  95      


Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe 
            100                 105                 110         


Leu Lys Glu Phe Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg 
        115                 120                 125             


Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr 
    130                 135                 140                 


Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile 
145                 150                 155                 160 


Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser 
                165                 170                 175     


Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu 
            180                 185                 190         


Thr Gly Ile Thr Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr 
        195                 200                 205             


Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys 
    210                 215                 220                 


Glu Val Arg Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu 
225                 230                 235                 240 


Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg 
                245                 250                 255     


Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser 
            260                 265                 270         


Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu 
        275                 280                 285             


Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly 
    290                 295                 300                 


Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp 
305                 310                 315                 320 


Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
                325                 330                 335     


Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu 
            340                 345                 350         


Lys Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln 
        355                 360                 365             


Glu Leu 
    370 


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 VH CDR1

<400>  3

Arg Cys Ala Met Ser 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 VH CDR2

<400>  4

Ala Ile Ser Arg Asp Ser Thr Tyr Thr Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 VH CDR3

<400>  5

Gln Ile Asp Asp Tyr Tyr Val Asp Ala Leu Asp Tyr 
1               5                   10          


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 VL CDR1

<400>  6

Arg Ala Ser Lys Ile Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 VL CDR2

<400>  7

Ser Gly Phe Thr Leu Gln Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 VL CDR3

<400>  8

Gln Gln His Asn Glu Tyr Pro Leu Thr 
1               5                   


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 VH

<400>  9

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Arg Cys 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Arg Asp Ser Thr Tyr Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ile Asp Asp Tyr Tyr Val Asp Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val 
        115         


<210>  10
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 VL

<400>  10

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ile Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Phe Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala 
            100 


<210>  11
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 HC LALAPG mIgG2a

<400>  11

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Arg 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Cys Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Ser Arg Asp Ser Thr Tyr Thr Tyr Tyr Ser 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Ile Asp Asp Tyr Tyr Val Asp Ala Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys 
465                 470 


<210>  12
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6D12 LC LALAPG mIgG2a

<400>  12

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala 
            20                  25                  30          


Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ile Ile 
        35                  40                  45              


Ser Lys Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Ile Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Gly Phe Thr Leu Gln Ser Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu 
            100                 105                 110         


Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 VH CDR1

<400>  13

Ser His Trp Met Gln 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 VH CDR2

<400>  14

Ala Ile Tyr Pro Gly Asp Gly Asp Thr Lys Phe Thr Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 VH CDR3

<400>  15

Asn Leu Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 VL CDR1

<400>  16

Arg Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Phe Ala Asn 
1               5                   10                  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 VL CDR2

<400>  17

Gly Ala Asp Asn Arg Ala Pro 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 VL CDR3

<400>  18

Ala Leu Trp Tyr Ser Asp His Trp Val 
1               5                   


<210>  19
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 VH

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met Gln Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Lys Phe Thr Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Leu Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu 
        115 


<210>  20
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 VL

<400>  20

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Ala Asp Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Ile Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Gly 
            100         


<210>  21
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 HC LALAPG mIgG2a

<400>  21

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser His Trp Met Gln Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Lys Phe Thr 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Leu Tyr Gly Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro 
225                 230                 235                 240 


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
            260                 265                 270         


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
    290                 295                 300                 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
305                 310                 315                 320 


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
                325                 330                 335     


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly Ala Pro 
            340                 345                 350         


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
        355                 360                 365             


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
    370                 375                 380                 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
385                 390                 395                 400 


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
            420                 425                 430         


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
        435                 440                 445             


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
    450                 455                 460                 


Thr Pro Gly Lys 
465             


<210>  22
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3B6 LC LALAPG mIgG2a

<400>  22

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Ser Gly Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Ala Asp Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Ile Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ser Thr Pro Thr Leu Thr Val Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Lys Glu Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asn 
145                 150                 155                 160 


Phe Ser Pro Ser Gly Val Thr Val Ala Trp Lys Ala Asn Gly Thr Pro 
                165                 170                 175     


Ile Thr Gln Gly Val Asp Thr Ser Asn Pro Thr Lys Glu Gly Asn Lys 
            180                 185                 190         


Phe Met Ala Ser Ser Phe Leu His Leu Thr Ser Asp Gln Trp Arg Ser 
        195                 200                 205             


His Asn Ser Phe Thr Cys Gln Val Thr His Glu Gly Asp Thr Val Glu 
    210                 215                 220                 


Lys Ser Leu Ser Arg Ala Asp Cys Leu 
225                 230             


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 VH CDR1

<400>  23

Asn Tyr Gly Val Asn 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 VH CDR2

<400>  24

Trp Ile Asn Thr Asn Thr Gly Gln Thr Thr Tyr Ala Glu Glu Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 VH CDR3

<400>  25

Leu Ile Tyr Asp Gly Asp Tyr Ile Ser Ser Asp Phe 
1               5                   10          


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 VL CDR1

<400>  26

Gly Ala Ser Glu Asn Ile Tyr Gly Ala Leu Asn 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 VL CDR2

<400>  27

Gly Ala Thr Asn Leu Ala Asp 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 VL CDR3

<400>  28

Gln Asn Ala Leu Ser Met Pro Tyr Thr 
1               5                   


<210>  29
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 VH

<400>  29

Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Arg Thr Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Gln Thr Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Arg Gly Arg Phe Ala Ile Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Thr Ile Ser Asn Leu Lys Asn Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Ile Tyr Asp Gly Asp Tyr Ile Ser Ser Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu 
        115         


<210>  30
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 VL

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro 
65                  70                  75                  80  


Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Ala Leu Ser Met Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly 
            100 


<210>  31
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 HC LALAPG mIgG2a

<400>  31

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Arg Thr Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Asn Tyr Gly Val Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Asn Thr Gly Gln Thr Thr Tyr Ala 
65                  70                  75                  80  


Glu Glu Phe Arg Gly Arg Phe Ala Ile Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Phe Leu Thr Ile Ser Asn Leu Lys Asn Glu Asp Ser Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Leu Ile Tyr Asp Gly Asp Tyr Ile Ser Ser Asp 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys 
465                 470 


<210>  32
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7D6 LC LALAPG mIgG2a

<400>  32

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile 
        35                  40                  45              


Tyr Gly Ala Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln 
    50                  55                  60                  


Leu Leu Ile Tyr Gly Ala Thr Asn Leu Ala Asp Gly Met Ser Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser 
                85                  90                  95      


Leu His Pro Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Ala Leu Ser 
            100                 105                 110         


Met Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 VH CDR1

<400>  33

Asn Tyr Glu Ile His 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 VH CDR2

<400>  34

Ala Ile His Pro Gly Asn Gly Val Thr Ala Tyr Asn Gln Met Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 VH CDR3

<400>  35

Asn Phe Asp Tyr 
1               


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 VL CDR1

<400>  36

Arg Ser Ser Gln Ser Leu Thr Asn Ser Tyr Gly Ile Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 VL CDR2

<400>  37

Glu Ile Ser Asn Arg Phe Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 VL CDR3

<400>  38

Leu Gln Gly Thr His Gln Pro Phe Thr 
1               5                   


<210>  39
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 VH

<400>  39

Gln Val Gln Phe Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Thr Cys Lys Ala Leu Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Glu Ile His Trp Val Arg Gln Pro Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile His Pro Gly Asn Gly Val Thr Ala Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ala Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Glu Asn Phe Asp Tyr Trp Gly Gln Gly Thr Ala Leu 
            100                 105                 


<210>  40
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 VL

<400>  40

Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Thr Asn Ser 
            20                  25                  30          


Tyr Gly Ile Thr Tyr Leu Ser Trp Phe Leu Leu Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Gly 
                85                  90                  95      


Thr His Gln Pro Phe Thr Phe Gly Ala 
            100                 105 


<210>  41
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 HC LALAPG mIgG2a

<400>  41

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Gln Val Gln Phe Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Thr Cys Lys Ala Leu Gly Tyr Thr Phe 
        35                  40                  45              


Ser Asn Tyr Glu Ile His Trp Val Arg Gln Pro Pro Val His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile His Pro Gly Asn Gly Val Thr Ala Tyr Asn 
65                  70                  75                  80  


Gln Met Phe Lys Gly Arg Ala Thr Leu Ala Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Glu Asn Phe Asp Tyr Trp Gly Gln Gly Thr Ala Leu 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Tyr Pro Leu Ala 
    130                 135                 140                 


Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly 
                165                 170                 175     


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
            180                 185                 190         


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro 
        195                 200                 205             


Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
225                 230                 235                 240 


Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
            260                 265                 270         


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
        275                 280                 285             


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
305                 310                 315                 320 


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Lys Val Asn Asn Lys Asp Leu Gly Ala Pro Ile Glu Arg Thr Ile Ser 
            340                 345                 350         


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
        355                 360                 365             


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
    370                 375                 380                 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
385                 390                 395                 400 


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
            420                 425                 430         


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460         


<210>  42
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3A8 LC LALAPG mIgG2a

<400>  42

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Phe Gly Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Thr Asn Ser Tyr Gly Ile Thr Tyr Leu Ser Trp Phe Leu Leu Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Glu Ile Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Thr Ile Lys Pro Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Leu Gln Gly Thr His Gln Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 VH CDR1

<400>  43

Asp Tyr Glu Ile His 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 VH CDR2

<400>  44

Gly Ile His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Pro Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 VH CDR3

<400>  45

Trp Val Asp Tyr 
1               


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 VL CDR1

<400>  46

Arg Ser Ser Gln Ser Leu Val Asn Arg His Gly Ile Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 VL CDR2

<400>  47

Glu Ile Ser Asn Arg Phe Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 VL CDR3

<400>  48

Phe Gln Gly Thr His Gln Pro Phe Thr 
1               5                   


<210>  49
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 VH

<400>  49

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile His Pro Gly Asn Gly Gly Thr Ala Tyr Asn Pro Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Ser 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Asp Trp Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 


<210>  50
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 VL

<400>  50

Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Asn Arg 
            20                  25                  30          


His Gly Ile Thr Tyr Leu Ser Trp Tyr Leu His Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Met Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr His Gln Pro Phe Thr Phe Gly Gly 
            100                 105 


<210>  51
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 HC LALAPG mIgG2a

<400>  51

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Leu Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gly Ile His Pro Gly Asn Gly Gly Thr Ala Tyr Asn 
65                  70                  75                  80  


Pro Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Ser Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Asp Trp Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
        115                 120                 125             


Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala 
    130                 135                 140                 


Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly 
                165                 170                 175     


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
            180                 185                 190         


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro 
        195                 200                 205             


Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
225                 230                 235                 240 


Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
            260                 265                 270         


Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
        275                 280                 285             


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
305                 310                 315                 320 


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Lys Val Asn Asn Lys Asp Leu Gly Ala Pro Ile Glu Arg Thr Ile Ser 
            340                 345                 350         


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
        355                 360                 365             


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
    370                 375                 380                 


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
385                 390                 395                 400 


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
            420                 425                 430         


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460         


<210>  52
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.2C11 LC LALAPG mIgG2a

<400>  52

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Asn Phe Gly Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val Asn Arg His Gly Ile Thr Tyr Leu Ser Trp Tyr Leu His Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Glu Ile Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Thr Ile Lys Pro Glu Asp Leu Gly Met Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Thr His Gln Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 VH CDR1

<400>  53

Asn Tyr Phe Ile His 
1               5   


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 VH CDR2

<400>  54

Trp Ile Asn Pro Gly Asn Leu Asn Thr Lys Tyr Thr Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 VH CDR3

<400>  55

Gly Asn Pro Phe Val Tyr 
1               5       


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 VL CDR1

<400>  56

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Lys Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 VL CDR2

<400>  57

Trp Thr Ser Thr Arg Asp Ser 
1               5           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 VL CDR3

<400>  58

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  59
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 VH

<400>  59

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Phe Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Leu Asn Thr Lys Tyr Thr Glu Glu Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Phe Val Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110     


<210>  60
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 VL

<400>  60

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Ile Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Lys Tyr Leu Thr Trp Leu Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala 
            100                 105     


<210>  61
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 HC LALAPG mIgG2a

<400>  61

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Phe Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Trp Ile Asn Pro Gly Asn Leu Asn Thr Lys Tyr Thr 
65                  70                  75                  80  


Glu Glu Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Ile Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Val Asn Gly Asn Pro Phe Val Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
            260                 265                 270         


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
        275                 280                 285             


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
305                 310                 315                 320 


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Lys Val Asn Asn Lys Asp Leu Gly Ala Pro Ile Glu Arg Thr 
            340                 345                 350         


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
        355                 360                 365             


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
    370                 375                 380                 


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
385                 390                 395                 400 


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
            420                 425                 430         


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460                 


<210>  62
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C1 LC LALAPG mIgG2a

<400>  62

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val 
            20                  25                  30          


Ile Ala Gly Glu Lys Val Thr Leu Asn Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asn Ser Gly Asn Gln Lys Lys Tyr Leu Thr Trp Leu Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 VH CDR1

<400>  63

Ser Tyr Trp Met His 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 VH CDR2

<400>  64

Ala Ile Tyr Pro Gly Lys Ser Asp Ile Lys Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 VH CDR3

<400>  65

Ser Ile Pro Phe Val Tyr 
1               5       


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 VL CDR1

<400>  66

Lys Ser Ser Gln Ser Leu Leu Asn Ser Glu Asn Gln Lys Lys Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 VL CDR2

<400>  67

Trp Thr Ser Thr Arg Tyr Ser 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 VL CDR3

<400>  68

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  69
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 VH

<400>  69

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ser Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Met Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Lys Ser Asp Ile Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ala Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Asn Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Asn Ser Ile Pro Phe Val Tyr Trp Gly Gln Gly Thr Leu Ile 
            100                 105                 110     


<210>  70
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 VL

<400>  70

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Glu Asn Gln Lys Lys Tyr Leu Thr Trp Phe Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Tyr Ser Gly Ile 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Asp Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gly 
            100                 105     


<210>  71
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 HC LALAPG mIgG2a

<400>  71

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ser Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Met 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Tyr Pro Gly Lys Ser Asp Ile Lys Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ala Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Ile Asn Ser Leu Thr Asn Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Asn Ser Ile Pro Phe Val Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Ile Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
            260                 265                 270         


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
        275                 280                 285             


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
305                 310                 315                 320 


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Lys Val Asn Asn Lys Asp Leu Gly Ala Pro Ile Glu Arg Thr 
            340                 345                 350         


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
        355                 360                 365             


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
    370                 375                 380                 


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
385                 390                 395                 400 


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
            420                 425                 430         


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460                 


<210>  72
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.1C7 LC mIgG2a

<400>  72

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val 
            20                  25                  30          


Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asn Ser Glu Asn Gln Lys Lys Tyr Leu Thr Trp Phe Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Tyr 
65                  70                  75                  80  


Ser Gly Ile Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Val Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Asp Asp Leu Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 VH CDR1

<400>  73

Ser Gly Glu Ser Trp His 
1               5       


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 VH CDR2

<400>  74

Phe Ile His Tyr Ser Gly Ser Ala Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 VH CDR3

<400>  75

Ser Val Tyr Asn Tyr Asp Gly Ala Trp Phe Pro Tyr 
1               5                   10          


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 VL CDR1

<400>  76

Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu Asn 
1               5                   10          


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 VL CDR2

<400>  77

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 VL CDR3

<400>  78

His Gln Trp Ser Ala Tyr Pro Pro Thr 
1               5                   


<210>  79
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 VH

<400>  79

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Glu Ser Trp His Trp Ile Arg His Phe Pro Gly Asn Glu Leu Glu Trp 
        35                  40                  45              


Met Gly Phe Ile His Tyr Ser Gly Ser Ala Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Leu Ser Val Thr Thr Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Tyr Asn Tyr Asp Gly Ala Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val 
        115         


<210>  80
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 VL

<400>  80

Gln Ile Val Leu Thr Gln Ser Pro Val Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Leu Lys Pro Gly Ser Ser Pro Lys Val Trp 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ala Tyr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly 
            100     


<210>  81
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 HC LALAPG mIgG2a

<400>  81

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Gly Glu Ser Trp His Trp Ile Arg His Phe Pro Gly Asn Glu 
    50                  55                  60                  


Leu Glu Trp Met Gly Phe Ile His Tyr Ser Gly Ser Ala Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Phe Leu Gln Leu Leu Ser Val Thr Thr Asp Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Val Tyr Asn Tyr Asp Gly Ala Trp Phe Pro 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys 
465                 470 


<210>  82
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.4G10 LC LALAPG mIgG2a

<400>  82

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Val Leu Thr Gln Ser Pro Val Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Arg Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              


Ser Ser Ser Tyr Leu Asn Trp Tyr Gln Leu Lys Pro Gly Ser Ser Pro 
    50                  55                  60                  


Lys Val Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Met Glu Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser 
            100                 105                 110         


Ala Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 VH CDR1

<400>  83

Ser Tyr Tyr Leu His 
1               5   


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 VH CDR2

<400>  84

Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Glu Tyr Thr Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 VH CDR3

<400>  85

Gly Asn Pro Phe Val Tyr 
1               5       


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 VL CDR1

<400>  86

Arg Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 VL CDR2

<400>  87

Trp Thr Ser Thr Arg Tyr Ser 
1               5           


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 VL CDR3

<400>  88

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  89
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 VH

<400>  89

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Glu Tyr Thr Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Phe Val Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110     


<210>  90
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 VL

<400>  90

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Phe Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Tyr Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala 
            100                 105     


<210>  91
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 HC LALAPG mIgG2a

<400>  91

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Glu Tyr Thr 
65                  70                  75                  80  


Gln Asn Phe Lys Asp Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Val Asn Gly Asn Pro Phe Val Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
            260                 265                 270         


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
        275                 280                 285             


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
305                 310                 315                 320 


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Lys Val Asn Asn Lys Asp Leu Gly Ala Pro Ile Glu Arg Thr 
            340                 345                 350         


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
        355                 360                 365             


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
    370                 375                 380                 


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
385                 390                 395                 400 


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
            420                 425                 430         


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460                 


<210>  92
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.6E10 LC LALAPG mIgG2a

<400>  92

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val 
            20                  25                  30          


Thr Thr Gly Glu Lys Val Thr Met Thr Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Phe Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Thr Arg Tyr 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 VH CDR1

<400>  93

Thr Tyr Gly Val His 
1               5   


<210>  94
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 VH CDR2

<400>  94

Val Ile Trp Arg Gly Gly Asn Thr Asp Tyr Asn Ala Ala Phe Met Ser 
1               5                   10                  15      


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 VH CDR3

<400>  95

Ser Ser Tyr Gly Tyr His Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 VL CDR1

<400>  96

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 VL CDR2

<400>  97

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 VL CDR3

<400>  98

Gln Arg Tyr Asn Asn Phe Pro Phe Thr 
1               5                   


<210>  99
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 VH

<400>  99

Gln Val Gln Leu Lys Gln Ser Gly Pro Ser Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Asn Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Gln Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ser Ser Tyr Gly Tyr His Tyr Thr Met Asp Tyr Trp Gly His Gly 
            100                 105                 110         


Thr Ser Val 
        115 


<210>  100
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 VL

<400>  100

Asp Ile Val Val Thr Gln Ser His Arg Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Arg Tyr Asn Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser 
            100 


<210>  101
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 HC LALAPG mIgG2a

<400>  101

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Gln Val Gln Leu Lys Gln Ser Gly Pro Ser Leu Val Gln 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Thr Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Arg Gly Gly Asn Thr Asp Tyr Asn Ala 
65                  70                  75                  80  


Ala Phe Met Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Gln Ser Gln 
                85                  90                  95      


Val Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr 
            100                 105                 110         


Tyr Cys Ala Lys Ser Ser Tyr Gly Tyr His Tyr Thr Met Asp Tyr Trp 
        115                 120                 125             


Gly His Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro 
225                 230                 235                 240 


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
            260                 265                 270         


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
    290                 295                 300                 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
305                 310                 315                 320 


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
                325                 330                 335     


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly Ala Pro 
            340                 345                 350         


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
        355                 360                 365             


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
    370                 375                 380                 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
385                 390                 395                 400 


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
            420                 425                 430         


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
        435                 440                 445             


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
    450                 455                 460                 


Thr Pro Gly Lys 
465             


<210>  102
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.3F7 LC LALAPG mIgG2a

<400>  102

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Val Thr Gln Ser His Arg Phe Met Ser Thr 
            20                  25                  30          


Ser Val Gly Asp Arg Val Ile Ile Thr Cys Lys Ala Ser Gln Asn Val 
        35                  40                  45              


Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg 
65                  70                  75                  80  


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn 
                85                  90                  95      


Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Arg Tyr Asn Asn 
            100                 105                 110         


Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  103
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 VH CDR1

<400>  103

Asn Ser Trp Ile Asn 
1               5   


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 VH CDR2

<400>  104

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Lys Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 VH CDR3

<400>  105

Phe Pro Phe Gly Lys Tyr Glu Gly Pro Gly Ala Met Asp Tyr 
1               5                   10                  


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 VL CDR1

<400>  106

Arg Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 VL CDR2

<400>  107

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 VL CDR3

<400>  108

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  109
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 VH

<400>  109

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Leu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ala Phe Ser Asn Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Leu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Lys Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Phe Pro Phe Gly Lys Tyr Glu Gly Pro Gly Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val 
        115                 


<210>  110
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 VL

<400>  110

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly 
            100 


<210>  111
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 HC  LALAPG mIgG2a

<400>  111

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Leu Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ala Phe 
        35                  40                  45              


Ser Asn Ser Trp Ile Asn Trp Val Lys Leu Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala His Met Gln Leu Arg Ser Leu Thr Ser Val Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Phe Pro Phe Gly Lys Tyr Glu Gly Pro Gly Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys 
    130                 135                 140                 


Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr 
145                 150                 155                 160 


Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 
        195                 200                 205             


Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu 
225                 230                 235                 240 


Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
                245                 250                 255     


Pro Asn Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
            260                 265                 270         


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
    290                 295                 300                 


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
305                 310                 315                 320 


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
                325                 330                 335     


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
            340                 345                 350         


Leu Gly Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
        355                 360                 365             


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
    370                 375                 380                 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
385                 390                 395                 400 


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
                405                 410                 415     


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
            420                 425                 430         


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
        435                 440                 445             


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
    450                 455                 460                 


Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470         


<210>  112
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.17A5 LC LALAPG mIgG2a

<400>  112

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 VH CDR1

<400>  113

Asp Tyr Val Ile Ser 
1               5   


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 VH CDR2

<400>  114

Glu Met Phe Pro Gly Ser Gly Thr Thr Tyr Tyr Thr Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 VH CDR3

<400>  115

Gly Thr Thr Ala Asp Tyr 
1               5       


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 VL  CDR1

<400>  116

Arg Ala Ser Ser Ser Val Asn Tyr Met Tyr 
1               5                   10  


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 VL CDR2

<400>  117

Tyr Thr Ser Asn Leu Ala Pro 
1               5           


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 VL CDR3

<400>  118

Gln Gln Phe Thr Ser Ser Pro Tyr Thr 
1               5                   


<210>  119
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 VH

<400>  119

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Met Phe Pro Gly Ser Gly Thr Thr Tyr Tyr Thr Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ala Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110     


<210>  120
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 VL

<400>  120

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Gly Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly 
            


<210>  121
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 HC  LALAPG mIgG2a

<400>  121

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Met Phe Pro Gly Ser Gly Thr Thr Tyr Tyr Thr 
65                  70                  75                  80  


Glu Lys Phe Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Thr Thr Ala Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
            260                 265                 270         


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
        275                 280                 285             


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
305                 310                 315                 320 


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Lys Val Asn Asn Lys Asp Leu Gly Ala Pro Ile Glu Arg Thr 
            340                 345                 350         


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
        355                 360                 365             


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
    370                 375                 380                 


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
385                 390                 395                 400 


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
            420                 425                 430         


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460                 


<210>  122
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.2C4 LC LALAPG mIgG2a

<400>  122

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          


Ser Leu Gly Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val 
        35                  40                  45              


Asn Tyr Met Tyr Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu 
    50                  55                  60                  


Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met 
                85                  90                  95      


Glu Gly Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
        115                 120                 125             


Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr 
    130                 135                 140                 


Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys 
145                 150                 155                 160 


Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly 
                165                 170                 175     


Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn 
        195                 200                 205             


Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val 
    210                 215                 220                 


Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230         


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 VH CDR1

<400>  123

Gly Tyr Phe Met His 
1               5   


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 VH CDR2

<400>  124

Tyr Ile Ser Cys Tyr Asn Gly Ala Ser Val Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 VH CDR3

<400>  125

Asp Val Leu Arg Tyr Pro Arg Tyr Ala Val Asp Tyr 
1               5                   10          


<210>  126
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 VL CDR1

<400>  126

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 VL CDR2

<400>  127

Leu Val Ser Asn Leu Asp Ser 
1               5           


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 VL CDR3

<400>  128

Trp Gln Gly Ser His Phe Pro Phe Thr 
1               5                   


<210>  129
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 VH

<400>  129

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Cys Tyr Asn Gly Ala Ser Val Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ile Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Arg Tyr Pro Arg Tyr Ala Val Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val 
        115         


<210>  130
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 VL

<400>  130

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Asn Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Ala Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Ser His Phe Pro Phe Thr Phe Gly Ser 
            100                 105 


<210>  131
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 HC LALAPG mIgG2a

<400>  131

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Thr Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Phe Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Ser Cys Tyr Asn Gly Ala Ser Val Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Lys Ala Thr Phe Thr Ile Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Val Leu Arg Tyr Pro Arg Tyr Ala Val Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys 
465                 470 


<210>  132
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.12E5 LC LALAPG mIgG2a

<400>  132

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Asn Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Trp Gln Gly Ser His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  133
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 VH CDR1

<400>  133

Gly Tyr Phe Met His 
1               5   


<210>  134
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 VH CDR2

<400>  134

Tyr Ile Ser Cys Tyr Asn Gly Val Ser Val Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 VH CDR3

<400>  135

Asp Val Leu Arg Tyr Pro Arg Tyr Ala Val Asp Tyr 
1               5                   10          


<210>  136
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 VL CDR1

<400>  136

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 VL CDR2

<400>  137

Leu Val Ser Asn Leu Asp Ser 
1               5           


<210>  138
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 VL CDR3

<400>  138

Trp Gln Gly Ser His Phe Pro Phe Thr 
1               5                   


<210>  139
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 VH

<400>  139

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Cys Tyr Asn Gly Val Ser Val Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ile Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Leu Arg Tyr Pro Arg Tyr Ala Val Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val 
        115         


<210>  140
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 VL

<400>  140

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Asn Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Ser His Phe Pro Phe Thr Phe Gly Ser 
            100                 105 


<210>  141
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 HC LALAPG mIgG2a

<400>  141

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Thr Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Phe Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Ser Cys Tyr Asn Gly Val Ser Val Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Lys Ala Thr Phe Thr Ile Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Val Leu Arg Tyr Pro Arg Tyr Ala Val Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys 
465                 470 


<210>  142
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11A10 LC LALAPG mIgG2a

<400>  142

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Asn Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Trp Gln Gly Ser His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  143
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 VH CDR1

<400>  143

Val Tyr Thr Met Asn 
1               5   


<210>  144
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 VH CDR2

<400>  144

Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ile Tyr Asn Arg Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  145
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 VH CDR3

<400>  145

Gly Ala Leu Tyr Arg Tyr Glu Gly Ala Met Asp Tyr 
1               5                   10          


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 VL CDR1

<400>  146

Arg Ala Ser Ser Ser Val Ile Tyr Val His 
1               5                   10  


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 VL CDR2

<400>  147

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  148
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 VL CDR3

<400>  148

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  149
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 VH

<400>  149

Glu Val Gln Val Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Val Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ile Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Leu Tyr Arg Tyr Glu Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Ile 
        115             


<210>  150
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 VL

<400>  150

Gln Ile Val Leu Ser Gln Phe Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ile Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser His Ser Leu Thr Ile Ser Arg Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala 
            


<210>  151
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 HC LALAPG mIgG2a

<400>  151

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Val Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Ile Val Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Arg Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Leu Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Ala Leu Tyr Arg Tyr Glu Gly Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Ile Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Ala Ala Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys 
465                 470 


<210>  152
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.11H11 LC LALAPG mIgG2a

<400>  152

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ile Val Leu Ser Gln Phe Pro Ala Ile Leu Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
        35                  40                  45              


Ile Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro 
    50                  55                  60                  


Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser His Ser Leu Thr Ile Ser Arg Leu 
                85                  90                  95      


Glu Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
            100                 105                 110         


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
        115                 120                 125             


Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr 
    130                 135                 140                 


Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys 
145                 150                 155                 160 


Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly 
                165                 170                 175     


Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn 
        195                 200                 205             


Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val 
    210                 215                 220                 


Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230         


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 VH CDR1

<400>  153

Asn Tyr Trp Met Asn 
1               5   


<210>  154
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 VH CDR2

<400>  154

Met Ile His Pro Ser Asp Ser Glu Ser Arg Leu Ser Gln Arg Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  155
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 VH CDR3

<400>  155

Leu Asp Tyr 
1           


<210>  156
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 VL CDR1

<400>  156

Lys Ser Ser Gln Ser Leu Leu Lys Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 VL CDR2

<400>  157

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 VL CDR3

<400>  158

Gln Gln His Tyr Ser Ala Pro Leu Thr 
1               5                   


<210>  159
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 VH

<400>  159

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Ser Arg Leu Ser Gln Arg Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105             


<210>  160
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 VL

<400>  160

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Lys Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Phe Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ala Pro Leu Thr Phe Gly Ala 
            100                 105     


<210>  161
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 HC  LALAPG mIgG2a

<400>  161

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Ala Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Met Ile His Pro Ser Asp Ser Glu Ser Arg Leu Ser 
65                  70                  75                  80  


Gln Arg Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Pro Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
        115                 120                 125             


Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
    130                 135                 140                 


Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser 
                165                 170                 175     


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
            180                 185                 190         


Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser 
        195                 200                 205             


Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
        275                 280                 285             


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
305                 310                 315                 320 


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
                325                 330                 335     


Val Asn Asn Lys Asp Leu Gly Ala Pro Ile Glu Arg Thr Ile Ser Lys 
            340                 345                 350         


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
        355                 360                 365             


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
    370                 375                 380                 


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
385                 390                 395                 400 


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
            420                 425                 430         


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
        435                 440                 445             


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460     


<210>  162
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4.29C4 LC LALAPG mIgG2a

<400>  162

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met 
            20                  25                  30          


Ser Val Gly Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Lys Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Val Phe Phe Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe 
            100                 105                 110         


Cys Gln Gln His Tyr Ser Ala Pro Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  163
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 VH CDR1

<400>  163

Ser Asn Tyr Tyr Met Cys 
1               5       


<210>  164
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 VH CDR2

<400>  164

Cys Val Tyr Val Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys 
    


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 VH CDR3

<400>  165

Asp Leu Ser Tyr Ala Gly Asp Leu 
1               5               


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 VL CDR1

<400>  166

Gln Ala Ser Glu Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 VL CDR2

<400>  167

Gly Ala Ser Asn Leu Ala Ser 
1               5           


<210>  168
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 VL CDR3

<400>  168

Gln Ser Ala Tyr Tyr Ser Asn Ser Gly Gly His Ala 
1               5                   10          


<210>  169
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 VH

<400>  169

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Asn Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Val Tyr Val Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Phe Ser Lys Thr Ser Ser Thr Thr Trp Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Tyr Ala Gly Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  170
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 VL

<400>  170

Asp Pro Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Ala Tyr Tyr Ser Asn Ser 
                85                  90                  95      


Gly Gly His Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  171
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 HC

<400>  171

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser 
        35                  40                  45              


Ser Asn Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ala Cys Val Tyr Val Gly Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Ser Trp Ala Lys Gly Arg Phe Thr Phe Ser Lys Thr Ser Ser Thr 
                85                  90                  95      


Thr Trp Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asp Leu Ser Tyr Ala Gly Asp Leu Trp Gly Pro 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val 
            180                 185                 190         


Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr 
        195                 200                 205             


Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr 
225                 230                 235                 240 


Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr 
        275                 280                 285             


Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg 
    290                 295                 300                 


Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile 
305                 310                 315                 320 


Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg 
            340                 345                 350         


Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu 
        355                 360                 365             


Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu 
385                 390                 395                 400 


Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr 
                405                 410                 415     


Phe Leu Tyr Asn Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly 
            420                 425                 430         


Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 


<210>  172
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17D12 LC

<400>  172

Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Val Ile Cys Asp Pro Val Met Thr Gln Thr Pro Ala Ser 
            20                  25                  30          


Val Ser Glu Pro Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Glu Ser Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser 
            100                 105                 110         


Ala Tyr Tyr Ser Asn Ser Gly Gly His Ala Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 


Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val 
145                 150                 155                 160 


Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly 
                165                 170                 175     


Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser 
            180                 185                 190         


Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr 
        195                 200                 205             


Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr 
    210                 215                 220                 


Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235     


<210>  173
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 VH CDR1

<400>  173

Ser Tyr Ala Met Gly 
1               5   


<210>  174
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 VH CDR2

<400>  174

Ile Ile Ser Ser Ser Gly Ser Thr His Tyr Ala Ser Trp Ala 
1               5                   10                  


<210>  175
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 VH CDR3

<400>  175

Ala Arg Ala Gly Ser Thr Tyr Tyr Thr Gly Tyr Tyr Phe Asn Leu 
1               5                   10                  15  


<210>  176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 VL CDR1

<400>  176

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 VL CDR2

<400>  177

Gly Ala Ser Thr Leu Glu Ser 
1               5           


<210>  178
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 VL CDR3

<400>  178

Gln Ser Gly Tyr Tyr Gly Ile Ser Ala Ile Asn Asn Ala 
1               5                   10              


<210>  179
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 VH

<400>  179

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser Ser Ser Gly Ser Thr His Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ala Arg 
                85                  90                  95      


Ala Gly Ser Thr Tyr Tyr Thr Gly Tyr Tyr Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  180
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 VL

<400>  180

Ala Ile Glu Met Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Gly Tyr Tyr Gly Ile Ser 
                85                  90                  95      


Ala Ile Asn Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  181
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 HC

<400>  181

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              


Ser Tyr Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ile Ile Ser Ser Ser Gly Ser Thr His Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Ala Arg Ala Gly Ser Thr Tyr Tyr Thr Gly Tyr Tyr Phe Asn Leu 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser 
145                 150                 155                 160 


Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe 
            180                 185                 190         


Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser 
225                 230                 235                 240 


Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro 
    290                 295                 300                 


Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr 
305                 310                 315                 320 


Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro 
        355                 360                 365             


Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly 
385                 390                 395                 400 


Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val Pro Thr Ser Glu Trp 
            420                 425                 430         


Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 460         


<210>  182
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.17H8 LC

<400>  182

Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Val Thr Phe Ala Ile Glu Met Thr Gln Thr Ala Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Glu Ser Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Arg Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Ser 
            100                 105                 110         


Gly Tyr Tyr Gly Ile Ser Ala Ile Asn Asn Ala Phe Gly Gly Gly Thr 
        115                 120                 125             


Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe 
    130                 135                 140                 


Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys 
145                 150                 155                 160 


Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp 
                165                 170                 175     


Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn 
            180                 185                 190         


Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser 
        195                 200                 205             


Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly 
    210                 215                 220                 


Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235         


<210>  183
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 VH CDR1

<400>  183

Tyr Asn Tyr Trp Ile Tyr 
1               5       


<210>  184
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 VH CDR2

<400>  184

Cys Ile Asn Thr Gly Asn Ser Gly Ile Thr Asn Tyr Ala Asn Trp Ala 
1               5                   10                  15      


Lys 
    


<210>  185
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 VH CDR3

<400>  185

Gly Gly Ile Asn Ser Gly Asp Tyr Met Asn Leu 
1               5                   10      


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 VL CDR1

<400>  186

Gln Ala Ser Glu Asn Ile Tyr Arg Leu Leu Ala 
1               5                   10      


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 VL CDR2

<400>  187

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  188
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 VL CDR3

<400>  188

Gln Gln Ala Tyr Ser Asn Ser Asn Ile Asp Asn Tyr 
1               5                   10          


<210>  189
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 VH

<400>  189

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Tyr Asn Tyr 
            20                  25                  30          


Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Asn Thr Gly Asn Ser Gly Ile Thr Asn Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Ile Asn Ser Gly Asp Tyr Met Asn Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  190
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 VL

<400>  190

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Arg Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Val Ser Gly Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Asn Ser Asn 
                85                  90                  95      


Ile Asp Asn Tyr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  191
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 HC

<400>  191

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser 
        35                  40                  45              


Tyr Asn Tyr Trp Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Cys Ile Asn Thr Gly Asn Ser Gly Ile Thr Asn Tyr 
65                  70                  75                  80  


Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr 
                85                  90                  95      


Thr Val Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Ile Asn Ser Gly Asp Tyr Met Asn Leu 
        115                 120                 125             


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser 
145                 150                 155                 160 


Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe 
            180                 185                 190         


Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser 
225                 230                 235                 240 


Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro 
    290                 295                 300                 


Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr 
305                 310                 315                 320 


Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro 
        355                 360                 365             


Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly 
385                 390                 395                 400 


Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val Pro Thr Ser Glu Trp 
            420                 425                 430         


Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 460         


<210>  192
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.11H2 LC

<400>  192

Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser 
            20                  25                  30          


Val Glu Val Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser 
        35                  40                  45              


Glu Asn Ile Tyr Arg Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr 
                85                  90                  95      


Val Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ala Tyr Ser Asn Ser Asn Ile Asp Asn Tyr Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 


Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val 
145                 150                 155                 160 


Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly 
                165                 170                 175     


Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser 
            180                 185                 190         


Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr 
        195                 200                 205             


Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr 
    210                 215                 220                 


Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235     


<210>  193
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 VH CDR1

<400>  193

Ser Lys Thr Ile Thr 
1               5   


<210>  194
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 VH CDR2

<400>  194

Phe Ile Asn Thr Asp Gly Arg Ala Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  


<210>  195
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 VH CDR3

<400>  195

Thr Asn Leu 
1           


<210>  196
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 VL CDR1

<400>  196

Gln Ala Ser Gln Ser Val Tyr Lys Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 VL CDR2

<400>  197

Ser Val Ser Thr Leu Asp Ser 
1               5           


<210>  198
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 VL CDR3

<400>  198

Leu Gly Ser Tyr Asp Cys Ser Ser Ala Asp Cys Ala Ala 
1               5                   10              


<210>  199
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 VH

<400>  199

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Lys Thr 
            20                  25                  30          


Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asn Thr Asp Gly Arg Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly Arg Thr Asn 
                85                  90                  95      


Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105             


<210>  200
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 VL

<400>  200

Ala Gln Val Leu Thr Gln Thr Ser Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Ser Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Lys Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Ser Val Ser Thr Leu Asp Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys 
                85                  90                  95      


Ser Ser Ala Asp Cys Ala Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  201
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 HC

<400>  201

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Ser Lys Thr Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Phe Ile Asn Thr Asp Gly Arg Ala Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Gly 
            100                 105                 110         


Arg Thr Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
    130                 135                 140                 


Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly 
                165                 170                 175     


Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn 
        195                 200                 205             


Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro 
    210                 215                 220                 


Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg 
        275                 280                 285             


Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg 
    290                 295                 300                 


Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr 
            340                 345                 350         


Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu 
        355                 360                 365             


Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp 
    370                 375                 380                 


Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val Pro 
                405                 410                 415     


Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  202
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5.14D6 LC

<400>  202

Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ser Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ser Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Val Tyr Lys Asn Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Arg Leu Ile Tyr Ser Val Ser Thr Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Ser Tyr Asp Cys Ser Ser Ala Asp Cys Ala Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu 
    130                 135                 140                 


Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile 
145                 150                 155                 160 


Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu 
                165                 170                 175     


Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro 
            180                 185                 190         


Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr 
    210                 215                 220                 


Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235                 


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 VH CDR1

<400>  203

Asp Tyr Asn Val Phe 
1               5   


<210>  204
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 VH CDR2

<400>  204

Tyr Ile Asp Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  205
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 VH CDR3

<400>  205

Gly Thr Val Arg Ala Phe Phe Asp Ser 
1               5                   


<210>  206
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5  VL CDR1

<400>  206

Lys Ser Ser Gln Ser Leu Leu Tyr Arg Asn Asp Gln Ile Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 VL CDR2

<400>  207

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 VL CDR3

<400>  208

Gln Gln Tyr Tyr Ser Tyr Pro Pro Thr 
1               5                   


<210>  209
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 VH

<400>  209

Glu Ile His Leu Gln Gln Ser Gly Pro Glu Val Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Lys Ala Ser Asp Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Val Phe Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Asp Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Tyr Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Val Arg Ala Phe Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu 
        


<210>  210
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 VL

<400>  210

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Ser Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Arg 
            20                  25                  30          


Asn Asp Gln Ile Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Val Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn 
65                  70                  75                  80  


Ile Asn Thr Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Pro Thr Phe Gly Thr 
            100                 105     


<210>  211
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 HC LALAPG mIgG2a

<400>  211

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala Tyr Ala Glu Ile His Leu Gln Gln Ser Gly Pro Glu Val Val Gln 
            20                  25                  30          


Pro Gly Ala Ser Leu Lys Val Ser Cys Lys Ala Ser Asp Tyr Ser Phe 
        35                  40                  45              


Thr Asp Tyr Asn Val Phe Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Ala Tyr Ile Asp Pro Tyr Asn Gly Ala Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met Tyr Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Thr Val Arg Ala Phe Phe Asp Ser Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
225                 230                 235                 240 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
            260                 265                 270         


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
        275                 280                 285             


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
305                 310                 315                 320 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Gly Ala Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
    370                 375                 380                 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
385                 390                 395                 400 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
            420                 425                 430         


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  212
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3.7F5 LC LALAPG mIgG2a

<400>  212

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val 
            20                  25                  30          


Ser Val Gly Glu Lys Val Ser Leu Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Tyr Arg Asn Asp Gln Ile Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Val Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile Asn Thr Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Tyr Tyr Ser Tyr Pro Pro Thr Phe Gly Thr Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  213
<211>  370
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(370)
<223>  Human APOL1 KIK isotype G0 form (no signal sequence)

<400>  213

Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr 
1               5                   10                  15      


Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met 
            20                  25                  30          


Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys 
        35                  40                  45              


Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu 
    50                  55                  60                  


Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala 
65                  70                  75                  80  


Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met 
                85                  90                  95      


Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe 
            100                 105                 110         


Leu Lys Glu Phe Pro Arg Leu Lys Ser Lys Leu Glu Asp Asn Ile Arg 
        115                 120                 125             


Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr 
    130                 135                 140                 


Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile 
145                 150                 155                 160 


Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser 
                165                 170                 175     


Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu 
            180                 185                 190         


Thr Gly Ile Thr Ser Ser Thr Ile Asp Tyr Gly Lys Lys Trp Trp Thr 
        195                 200                 205             


Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys 
    210                 215                 220                 


Glu Val Lys Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu 
225                 230                 235                 240 


Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg 
                245                 250                 255     


Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser 
            260                 265                 270         


Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu 
        275                 280                 285             


Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly 
    290                 295                 300                 


Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp 
305                 310                 315                 320 


Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
                325                 330                 335     


Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu 
            340                 345                 350         


Lys Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln 
        355                 360                 365             


Glu Leu 
    370 


<210>  214
<211>  370
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(370)
<223>  Human APOL1 EIK isotype G0 form (no signal sequence)

<400>  214

Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr 
1               5                   10                  15      


Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met 
            20                  25                  30          


Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys 
        35                  40                  45              


Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu 
    50                  55                  60                  


Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala 
65                  70                  75                  80  


Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met 
                85                  90                  95      


Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe 
            100                 105                 110         


Leu Lys Glu Phe Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg 
        115                 120                 125             


Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr 
    130                 135                 140                 


Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile 
145                 150                 155                 160 


Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser 
                165                 170                 175     


Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu 
            180                 185                 190         


Thr Gly Ile Thr Ser Ser Thr Ile Asp Tyr Gly Lys Lys Trp Trp Thr 
        195                 200                 205             


Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys 
    210                 215                 220                 


Glu Val Lys Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu 
225                 230                 235                 240 


Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg 
                245                 250                 255     


Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser 
            260                 265                 270         


Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu 
        275                 280                 285             


Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly 
    290                 295                 300                 


Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp 
305                 310                 315                 320 


Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
                325                 330                 335     


Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu 
            340                 345                 350         


Lys Leu Asn Ile Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln 
        355                 360                 365             


Glu Leu 
    370 


<210>  215
<211>  370
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(370)
<223>  Human APOL1 G1 variant of EMR isotype (no signal sequence)

<400>  215

Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr 
1               5                   10                  15      


Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met 
            20                  25                  30          


Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys 
        35                  40                  45              


Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu 
    50                  55                  60                  


Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala 
65                  70                  75                  80  


Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met 
                85                  90                  95      


Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe 
            100                 105                 110         


Leu Lys Glu Phe Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg 
        115                 120                 125             


Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr 
    130                 135                 140                 


Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile 
145                 150                 155                 160 


Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser 
                165                 170                 175     


Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu 
            180                 185                 190         


Thr Gly Ile Thr Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr 
        195                 200                 205             


Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys 
    210                 215                 220                 


Glu Val Arg Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu 
225                 230                 235                 240 


Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg 
                245                 250                 255     


Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser 
            260                 265                 270         


Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu 
        275                 280                 285             


Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly 
    290                 295                 300                 


Val Lys Leu Thr Asp Val Ala Pro Val Gly Phe Phe Leu Val Leu Asp 
305                 310                 315                 320 


Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
                325                 330                 335     


Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu 
            340                 345                 350         


Lys Leu Asn Met Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln 
        355                 360                 365             


Glu Leu 
    370 


<210>  216
<211>  368
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(368)
<223>  Human APOL1 G2 variant of EMR isotype (no signal sequence)

<400>  216

Glu Ala Gly Ala Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr 
1               5                   10                  15      


Gly Asp Pro Gln Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met 
            20                  25                  30          


Asp Pro Glu Ser Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys 
        35                  40                  45              


Glu Lys Val Ser Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu 
    50                  55                  60                  


Ala Trp Asn Gly Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala 
65                  70                  75                  80  


Asp Glu Leu Arg Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met 
                85                  90                  95      


Lys Asp Lys Asn Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe 
            100                 105                 110         


Leu Lys Glu Phe Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg 
        115                 120                 125             


Arg Leu Arg Ala Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr 
    130                 135                 140                 


Thr Ile Ala Asn Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile 
145                 150                 155                 160 


Leu Thr Leu Val Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser 
                165                 170                 175     


Leu Val Leu Leu Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu 
            180                 185                 190         


Thr Gly Ile Thr Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr 
        195                 200                 205             


Gln Ala Gln Ala His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys 
    210                 215                 220                 


Glu Val Arg Glu Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu 
225                 230                 235                 240 


Ala Gly Asn Thr Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg 
                245                 250                 255     


Ala Leu Arg Arg Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser 
            260                 265                 270         


Ala Ser Arg Pro Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu 
        275                 280                 285             


Gln Val Glu Arg Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly 
    290                 295                 300                 


Val Lys Leu Thr Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp 
305                 310                 315                 320 


Val Val Tyr Leu Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys 
                325                 330                 335     


Ser Glu Thr Ala Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu 
            340                 345                 350         


Lys Leu Asn Ile Leu Asn Asn Lys Ile Leu Gln Ala Asp Gln Glu Leu 
        355                 360                 365             


<210>  217
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: vA (v1)

<400>  217

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly 
        35                  40      


<210>  218
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: vB1 (v2)

<400>  218

Met Arg Phe Lys Ser His Thr Val Glu Leu Arg Arg Pro Cys Ser Asp 
1               5                   10                  15      


Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
            20                  25                  30          


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
        35                  40                  45              


Arg Val Gln Gln Asn Val Pro Ser Gly 
    50                  55          


<210>  219
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: vB3 (v2-3)

<400>  219

Met Arg Phe Lys Ser His Thr Val Glu Leu Arg Arg Pro Cys Ser Asp 
1               5                   10                  15      


Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Val 
            20                  25                  30          


Gln Gln Asn Val Pro Ser Gly 
        35                  


<210>  220
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: vC (v4)

<400>  220

Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Val 
1               5                   10                  15      


Gln Gln Asn Val Pro Ser Gly 
            20              


