                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  NUCLEOBASE EDITORS

<130>  9869SG6003

<150>  SG 10201913340Q
<151>  2019-12-26

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nCas9 (Cas9 nickase)

<400>  1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  2
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cas9 (Wildtype)

<400>  2

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  3
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC

<400>  3

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  4
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rXRCC1

<400>  4

Met Pro Glu Ile Ser Leu Arg His Val Val Ser Cys Ser Ser Gln Asp 
1               5                   10                  15      


Ser Thr His Arg Ala Glu Asn Leu Leu Lys Ala Asp Thr Tyr Arg Lys 
            20                  25                  30          


Trp Arg Ser Ala Lys Ala Gly Glu Lys Thr Ile Ser Val Val Leu Gln 
        35                  40                  45              


Leu Glu Lys Glu Glu Gln Ile His Ser Val Asp Ile Gly Asn Asp Gly 
    50                  55                  60                  


Ser Ala Phe Val Glu Val Leu Val Gly Ser Ser Ala Gly Gly Ala Thr 
65                  70                  75                  80  


Ala Gly Glu Gln Asp Tyr Glu Val Leu Leu Val Thr Ser Ser Phe Met 
                85                  90                  95      


Ser Pro Ser Glu Ser Arg Ser Gly Ser Asn Pro Asn Arg Val Arg Ile 
            100                 105                 110         


Phe Gly Pro Asp Lys Leu Val Arg Ala Ala Ala Glu Lys Arg Trp Asp 
        115                 120                 125             


Arg Val Lys Ile Val Cys Ser Gln Pro Tyr Ser Lys Asp Ser Pro Tyr 
    130                 135                 140                 


Gly Leu Ser Phe Val Lys Phe His Ser Pro Pro Asp Lys Asp Glu Ala 
145                 150                 155                 160 


Glu Ala Pro Ser Gln Lys Val Thr Val Thr Lys Leu Gly Gln Phe Arg 
                165                 170                 175     


Val Lys Glu Glu Asp Asp Ser Ala Asn Ser Leu Arg Pro Gly Ala Leu 
            180                 185                 190         


Phe Phe Asn Arg Ile Asn Lys Ala Ala Ser Ala Ser Ala Ser Asp Pro 
        195                 200                 205             


Ala Gly Pro Ser Tyr Ala Ala Ala Thr Leu Gln Ala Ser Ser Ala Ala 
    210                 215                 220                 


Ser Ser Ala Leu Pro Val Pro Lys Val Gly Gly Ser Ser Ser Lys Leu 
225                 230                 235                 240 


Gln Glu Pro Pro Lys Gly Lys Arg Lys Leu Asp Leu Gly Leu Glu Asp 
                245                 250                 255     


Ser Lys Pro Pro Ser Lys Pro Ser Ala Gly Pro Ala Ala Leu Lys Arg 
            260                 265                 270         


Pro Lys Leu Pro Val Pro Ser Arg Thr Pro Ala Ala Thr Pro Ala Ser 
        275                 280                 285             


Thr Pro Ala Gln Lys Ala Val Pro Gly Lys Pro Arg Gly Glu Gly Thr 
    290                 295                 300                 


Glu Pro Arg Gly Ala Arg Ala Gly Pro Gln Glu Leu Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gly Val Val Val Val Leu Ser Gly Phe Gln Asn Pro Phe Arg Ser 
                325                 330                 335     


Glu Leu Arg Asp Lys Ala Leu Glu Leu Gly Ala Lys Tyr Arg Pro Asp 
            340                 345                 350         


Trp Thr Pro Asp Ser Thr His Leu Ile Cys Ala Phe Ala Asn Thr Pro 
        355                 360                 365             


Lys Tyr Ser Gln Val Leu Gly Leu Gly Gly Arg Ile Val Arg Lys Glu 
    370                 375                 380                 


Trp Val Leu Asp Cys Tyr Arg Met Arg Arg Arg Leu Pro Ser Arg Arg 
385                 390                 395                 400 


Tyr Leu Met Ala Gly Leu Gly Ser Ser Ser Glu Asp Glu Gly Asp Ser 
                405                 410                 415     


His Ser Glu Ser Gly Glu Asp Glu Ala Pro Lys Leu Pro Arg Lys Arg 
            420                 425                 430         


Pro Gln Pro Lys Ala Lys Thr Gln Ala Ala Gly Pro Ser Ser Pro Pro 
        435                 440                 445             


Arg Pro Pro Thr Pro Glu Glu Thr Lys Ala Pro Ser Pro Gly Pro Gln 
    450                 455                 460                 


Asp Asn Ser Asp Thr Asp Gly Glu Gln Ser Glu Gly Arg Asp Asn Gly 
465                 470                 475                 480 


Ala Glu Asp Ser Gly Asp Thr Glu Asp Glu Leu Arg Arg Val Ala Lys 
                485                 490                 495     


Gln Arg Glu Gln Arg Gln Pro Pro Ala Pro Glu Glu Asn Gly Glu Asp 
            500                 505                 510         


Pro Tyr Ala Gly Ser Thr Asp Glu Asn Thr Asp Ser Glu Ala Pro Ser 
        515                 520                 525             


Glu Ala Asp Leu Pro Ile Pro Glu Leu Pro Asp Phe Phe Gln Gly Lys 
    530                 535                 540                 


His Phe Phe Leu Tyr Gly Glu Phe Pro Gly Asp Glu Arg Arg Lys Leu 
545                 550                 555                 560 


Ile Arg Tyr Val Thr Ala Phe Asn Gly Glu Leu Glu Asp Tyr Met Ser 
                565                 570                 575     


Asp Arg Val Gln Phe Val Ile Thr Ala Gln Glu Trp Asp Pro Asn Phe 
            580                 585                 590         


Glu Glu Ala Leu Met Glu Asn Pro Ser Leu Ala Phe Val Arg Pro Arg 
        595                 600                 605             


Trp Ile Tyr Ser Cys Asn Glu Lys Gln Lys Leu Leu Pro His Gln Leu 
    610                 615                 620                 


Tyr Gly Val Val Pro Gln Ala 
625                 630     


<210>  5
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hXRCC1

<400>  5

Met Gly Pro Glu Ile Arg Leu Arg His Val Val Ser Cys Ser Ser Gln 
1               5                   10                  15      


Asp Ser Thr His Cys Ala Glu Asn Leu Leu Lys Ala Asp Thr Tyr Arg 
            20                  25                  30          


Lys Trp Arg Ala Ala Lys Ala Gly Glu Lys Thr Ile Ser Val Val Leu 
        35                  40                  45              


Gln Leu Glu Lys Glu Glu Gln Ile His Ser Val Asp Ile Gly Asn Asp 
    50                  55                  60                  


Gly Ser Ala Phe Val Glu Val Leu Val Gly Ser Ser Ala Gly Gly Ala 
65                  70                  75                  80  


Gly Glu Gln Asp Tyr Glu Val Leu Leu Val Thr Ser Ser Phe Met Ser 
                85                  90                  95      


Pro Ser Glu Ser Arg Ser Gly Ser Asn Pro Asn Arg Val Arg Met Phe 
            100                 105                 110         


Gly Pro Asp Lys Leu Val Arg Ala Ala Ala Glu Lys Arg Trp Asp Arg 
        115                 120                 125             


Val Lys Ile Val Cys Ser Gln Pro Tyr Ser Lys Asp Ser Pro Phe Gly 
    130                 135                 140                 


Leu Ser Phe Val Arg Phe His Ser Pro Pro Asp Lys Asp Glu Ala Glu 
145                 150                 155                 160 


Ala Pro Ser Gln Lys Val Thr Val Thr Lys Leu Gly Gln Phe Arg Val 
                165                 170                 175     


Lys Glu Glu Asp Glu Ser Ala Asn Ser Leu Arg Pro Gly Ala Leu Phe 
            180                 185                 190         


Phe Ser Arg Ile Asn Lys Thr Ser Pro Val Thr Ala Ser Asp Pro Ala 
        195                 200                 205             


Gly Pro Ser Tyr Ala Ala Ala Thr Leu Gln Ala Ser Ser Ala Ala Ser 
    210                 215                 220                 


Ser Ala Ser Pro Val Ser Arg Ala Ile Gly Ser Thr Ser Lys Pro Gln 
225                 230                 235                 240 


Glu Ser Pro Lys Gly Lys Arg Lys Leu Asp Leu Asn Gln Glu Glu Lys 
                245                 250                 255     


Lys Thr Pro Ser Lys Pro Pro Ala Gln Leu Ser Pro Ser Val Pro Lys 
            260                 265                 270         


Arg Pro Lys Leu Pro Ala Pro Thr Arg Thr Pro Ala Thr Ala Pro Val 
        275                 280                 285             


Pro Ala Arg Ala Gln Gly Ala Val Thr Gly Lys Pro Arg Gly Glu Gly 
    290                 295                 300                 


Thr Glu Pro Arg Arg Pro Arg Ala Gly Pro Glu Glu Leu Gly Lys Ile 
305                 310                 315                 320 


Leu Gln Gly Val Val Val Val Leu Ser Gly Phe Gln Asn Pro Phe Arg 
                325                 330                 335     


Ser Glu Leu Arg Asp Lys Ala Leu Glu Leu Gly Ala Lys Tyr Arg Pro 
            340                 345                 350         


Asp Trp Thr Arg Asp Ser Thr His Leu Ile Cys Ala Phe Ala Asn Thr 
        355                 360                 365             


Pro Lys Tyr Ser Gln Val Leu Gly Leu Gly Gly Arg Ile Val Arg Lys 
    370                 375                 380                 


Glu Trp Val Leu Asp Cys His Arg Met Arg Arg Arg Leu Pro Ser Gln 
385                 390                 395                 400 


Arg Tyr Leu Met Ala Gly Pro Gly Ser Ser Ser Glu Glu Asp Glu Ala 
                405                 410                 415     


Ser His Ser Gly Gly Ser Gly Asp Glu Ala Pro Lys Leu Pro Gln Lys 
            420                 425                 430         


Gln Pro Gln Thr Lys Thr Lys Pro Thr Gln Ala Ala Gly Pro Ser Ser 
        435                 440                 445             


Pro Gln Lys Pro Pro Thr Pro Glu Glu Thr Lys Ala Ala Ser Pro Val 
    450                 455                 460                 


Leu Gln Glu Asp Ile Asp Ile Glu Gly Val Gln Ser Glu Gly Gln Asp 
465                 470                 475                 480 


Asn Gly Ala Glu Asp Ser Gly Asp Thr Glu Asp Glu Leu Arg Arg Val 
                485                 490                 495     


Ala Glu Gln Lys Glu His Arg Leu Pro Pro Gly Gln Glu Glu Asn Gly 
            500                 505                 510         


Glu Asp Pro Tyr Ala Gly Ser Thr Asp Glu Asn Thr Asp Ser Glu Glu 
        515                 520                 525             


His Gln Glu Pro Pro Asp Leu Pro Val Pro Glu Leu Pro Asp Phe Phe 
    530                 535                 540                 


Gln Gly Lys His Phe Phe Leu Tyr Gly Glu Phe Pro Gly Asp Glu Arg 
545                 550                 555                 560 


Arg Lys Leu Ile Arg Tyr Val Thr Ala Phe Asn Gly Glu Leu Glu Asp 
                565                 570                 575     


Tyr Met Ser Asp Arg Val Gln Phe Val Ile Thr Ala Gln Glu Trp Asp 
            580                 585                 590         


Pro Ser Phe Glu Glu Ala Leu Met Asp Asn Pro Ser Leu Ala Phe Val 
        595                 600                 605             


Arg Pro Arg Trp Ile Tyr Ser Cys Asn Glu Lys Gln Lys Leu Leu Pro 
    610                 615                 620                 


His Gln Leu Tyr Gly Val Val Pro Gln Ala 
625                 630                 


<210>  6
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rPB_8KD

<400>  6

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Val Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys 
                85          


<210>  7
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rPB_14KD

<400>  7

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Val Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Asn Phe Leu Thr Arg Val Thr Gly Ile Gly Pro Ser Ala Ala Arg 
            100                 105                 110         


Lys Leu Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 
        115                 120                 125             


Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys 
    130                 135                 140     


<210>  8
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPBI_8KD

<400>  8

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys 
                85          


<210>  9
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPBI_14KD

<400>  9

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg 
            100                 105                 110         


Lys Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 
        115                 120                 125             


Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys 
    130                 135                 140     


<210>  10
<211>  943
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rLIG3

<400>  10

Met Thr Leu Ala Phe Lys Thr Leu Phe Pro Arg Asn Leu Cys Ala Leu 
1               5                   10                  15      


Gly Arg Lys Glu Leu Cys Leu Phe Ser Glu Gln His His Trp Pro Ala 
            20                  25                  30          


Ile Arg Gln Phe Ser Gln Trp Ser Glu Thr Asn Leu Leu Cys Gly Cys 
        35                  40                  45              


Cys Leu Leu Gln Arg Arg Lys Pro Val Leu Ser Phe Gln Arg Gly His 
    50                  55                  60                  


Leu Arg Pro Arg Ala Thr His Leu Ile Ser Trp Ser Gly Ser His Val 
65                  70                  75                  80  


Gly Leu Cys Thr Gly Pro Cys Glu Met Ala Glu Gln Arg Phe Cys Val 
                85                  90                  95      


Asp Tyr Ala Lys Arg Gly Thr Ala Gly Cys Lys Lys Cys Lys Glu Lys 
            100                 105                 110         


Ile Val Lys Gly Val Cys Arg Ile Gly Lys Val Val Pro Asn Pro Phe 
        115                 120                 125             


Ser Glu Ser Gly Gly Asp Met Lys Glu Trp Tyr His Ile Lys Cys Met 
    130                 135                 140                 


Phe Glu Lys Leu Glu Arg Ala Arg Ala Thr Thr Lys Lys Ile Glu Asp 
145                 150                 155                 160 


Leu Thr Glu Leu Glu Gly Trp Glu Glu Leu Glu Asp Asn Glu Lys Glu 
                165                 170                 175     


Gln Ile Ser Gln His Ile Ala Asp Leu Ser Ser Lys Thr Ala Ala Thr 
            180                 185                 190         


Pro Lys Lys Lys Ala Thr Val Gln Ala Lys Leu Thr Thr Thr Gly Gln 
        195                 200                 205             


Val Thr Ser Pro Val Lys Gly Ala Ser Phe Ile Thr Ser Thr Asn Pro 
    210                 215                 220                 


Arg Lys Phe Ser Gly Phe Ser Ala Ala Lys Pro Asn Asn Ser Glu Gln 
225                 230                 235                 240 


Asp Pro Ser Ser Pro Ala Pro Lys Thr Ser Leu Ser Ala Ser Lys Cys 
                245                 250                 255     


Asp Pro Lys His Lys Asp Cys Leu Leu Arg Glu Phe Arg Lys Leu Cys 
            260                 265                 270         


Ala Met Val Ala Glu Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile 
        275                 280                 285             


His Asp Phe Leu Gln Lys Gly Ser Thr Gly Asp Gly Phe Arg Gly Asp 
    290                 295                 300                 


Val Tyr Leu Thr Val Lys Leu Leu Leu Pro Gly Val Ile Lys Ser Val 
305                 310                 315                 320 


Tyr Asn Leu Asn Asp Lys Gln Ile Val Lys Leu Phe Ser Arg Ile Phe 
                325                 330                 335     


Asn Cys Asn Pro Asp Asp Met Ala Arg Asp Leu Glu Gln Gly Asp Val 
            340                 345                 350         


Ser Glu Thr Ile Arg Val Phe Phe Glu Gln Ser Lys Ser Phe Pro Pro 
        355                 360                 365             


Ala Ala Lys Ser Leu Leu Thr Ile Gln Glu Val Asp Ala Phe Leu Leu 
    370                 375                 380                 


His Leu Ser Lys Leu Thr Lys Glu Asp Glu Gln Gln Gln Ala Leu Gln 
385                 390                 395                 400 


Asp Ile Ala Ser Arg Cys Thr Ala Asn Asp Leu Lys Cys Ile Ile Arg 
                405                 410                 415     


Leu Ile Lys His Asp Leu Lys Met Asn Ser Gly Ala Lys His Val Leu 
            420                 425                 430         


Asp Ala Leu Asp Pro Asn Ala Tyr Glu Ala Phe Lys Ala Ser Arg Asn 
        435                 440                 445             


Leu Gln Asp Val Val Glu Arg Val Leu His Asn Glu Gln Glu Val Glu 
    450                 455                 460                 


Lys Asp Pro Gly Arg Arg Arg Ala Leu Ser Val Gln Ala Ser Leu Met 
465                 470                 475                 480 


Thr Pro Val Gln Pro Met Leu Ala Glu Ala Cys Lys Ser Ile Glu Tyr 
                485                 490                 495     


Ala Met Lys Lys Cys Pro Asn Gly Met Phe Ser Glu Ile Lys Tyr Asp 
            500                 505                 510         


Gly Glu Arg Val Gln Val His Lys Lys Gly Asp His Phe Ser Tyr Phe 
        515                 520                 525             


Ser Arg Ser Leu Lys Pro Val Leu Pro His Lys Val Ala His Phe Lys 
    530                 535                 540                 


Asp Tyr Ile Pro Lys Ala Phe Pro Gly Gly Gln Ser Met Ile Leu Asp 
545                 550                 555                 560 


Ser Glu Val Leu Leu Ile Asp Asn Asn Thr Gly Lys Pro Leu Pro Phe 
                565                 570                 575     


Gly Thr Leu Gly Val His Lys Lys Ala Ala Phe Gln Asp Ala Asn Val 
            580                 585                 590         


Cys Leu Phe Val Phe Asp Cys Ile Tyr Phe Asn Asp Val Ser Leu Met 
        595                 600                 605             


Asp Arg Pro Leu Cys Glu Arg Arg Lys Phe Leu His Asp Asn Met Val 
    610                 615                 620                 


Glu Ile Arg Asn Arg Ile Met Phe Ser Glu Met Lys Gln Val Thr Lys 
625                 630                 635                 640 


Ala Ser Asp Leu Ala Asp Met Ile Asn Arg Val Ile Arg Glu Gly Leu 
                645                 650                 655     


Glu Gly Leu Val Leu Lys Asp Val Lys Gly Thr Tyr Glu Pro Gly Lys 
            660                 665                 670         


Arg His Trp Leu Lys Val Lys Lys Asp Tyr Leu Asn Glu Gly Ala Met 
        675                 680                 685             


Ala Asp Thr Ala Asp Leu Val Val Leu Gly Ala Phe Tyr Gly Gln Gly 
    690                 695                 700                 


Ser Lys Gly Gly Met Met Ser Ile Phe Leu Met Gly Cys Tyr Asp Pro 
705                 710                 715                 720 


Asp Ser Gln Lys Trp Cys Thr Val Thr Lys Cys Ala Gly Gly His Asp 
                725                 730                 735     


Asp Ala Thr Leu Ala Arg Leu Gln Lys Glu Leu Asp Met Val Lys Ile 
            740                 745                 750         


Ser Lys Asp Pro Ser Lys Ile Pro Ser Trp Leu Lys Ile Asn Lys Ile 
        755                 760                 765             


Tyr Tyr Pro Asp Phe Ile Val Pro Asp Pro Lys Lys Ala Ala Val Trp 
    770                 775                 780                 


Glu Ile Thr Gly Ala Glu Phe Ser Arg Ser Glu Ala His Thr Ala Asp 
785                 790                 795                 800 


Gly Ile Ser Ile Arg Phe Pro Arg Cys Thr Arg Ile Arg Asp Asp Lys 
                805                 810                 815     


Asp Trp Lys Ser Ala Thr Asn Leu Pro Gln Leu Lys Glu Leu Tyr Gln 
            820                 825                 830         


Leu Ser Lys Asp Lys Ala Asp Phe Ala Val Val Ala Gly Asp Glu Gly 
        835                 840                 845             


Ser Ser Thr Thr Gly Gly Ser Asn Gly Glu Asn Glu Gly Thr Ala Gly 
    850                 855                 860                 


Ser Thr Val Pro Arg Lys Gly Pro Lys Gly Pro Pro Ser Lys Ser Ser 
865                 870                 875                 880 


Ala Ser Ala Lys Lys Thr Glu Gln Lys Leu Asn Asp Pro Ser Ser Arg 
                885                 890                 895     


Gly Gly Glu Lys Leu Ala Val Lys Ser Ser Pro Val Lys Val Gly Met 
            900                 905                 910         


Lys Arg Lys Ala Ala Asp Glu Thr Pro Gly Leu Thr Lys Arg Arg Arg 
        915                 920                 925             


Ala Ser Arg Gln Arg Gly Arg Arg Ala Met Arg Thr Gly Arg Arg 
    930                 935                 940             


<210>  11
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hLIG3

<400>  11

Met Ser Lys Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln Ala 
1               5                   10                  15      


Lys Leu Thr Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala Ser 
            20                  25                  30          


Phe Val Thr Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala Lys 
        35                  40                  45              


Pro Asn Asn Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg Ser 
    50                  55                  60                  


Leu Ser Ser Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu Arg 
65                  70                  75                  80  


Glu Phe Arg Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr Asn 
                85                  90                  95      


Thr Lys Thr Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala Gly 
            100                 105                 110         


Asp Gly Phe His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu Pro 
        115                 120                 125             


Gly Val Ile Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val Lys 
    130                 135                 140                 


Leu Phe Ser Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg Asp 
145                 150                 155                 160 


Leu Glu Gln Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu Gln 
                165                 170                 175     


Ser Lys Ser Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln Glu 
            180                 185                 190         


Val Asp Glu Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp Glu 
        195                 200                 205             


Gln Gln Gln Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn Asp 
    210                 215                 220                 


Leu Lys Cys Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn Ser 
225                 230                 235                 240 


Gly Ala Lys His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu Ala 
                245                 250                 255     


Phe Lys Ala Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu His 
            260                 265                 270         


Asn Ala Gln Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu Ser 
        275                 280                 285             


Val Gln Ala Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu Ala 
    290                 295                 300                 


Cys Lys Ser Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met Phe 
305                 310                 315                 320 


Ser Glu Ile Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn Gly 
                325                 330                 335     


Asp His Phe Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro His 
            340                 345                 350         


Lys Val Ala His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly Gly 
        355                 360                 365             


His Ser Met Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys Thr 
    370                 375                 380                 


Gly Lys Pro Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala Ala 
385                 390                 395                 400 


Phe Gln Asp Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr Phe 
                405                 410                 415     


Asn Asp Val Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys Phe 
            420                 425                 430         


Leu His Asp Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser Glu 
        435                 440                 445             


Met Lys Arg Val Thr Lys Ala Leu Asp Leu Ala Asp Met Ile Thr Arg 
    450                 455                 460                 


Val Ile Gln Glu Gly Leu Glu Gly Leu Val Leu Lys Asp Val Lys Gly 
465                 470                 475                 480 


Thr Tyr Glu Pro Gly Lys Arg His Trp Leu Lys Val Lys Lys Asp Tyr 
                485                 490                 495     


Leu Asn Glu Gly Ala Met Ala Asp Thr Ala Asp Leu Val Val Leu Gly 
            500                 505                 510         


Ala Phe Tyr Gly Gln Gly Ser Lys Gly Gly Met Met Ser Ile Phe Leu 
        515                 520                 525             


Met Gly Cys Tyr Asp Pro Gly Ser Gln Lys Trp Cys Thr Val Thr Lys 
    530                 535                 540                 


Cys Ala Gly Gly His Asp Asp Ala Thr Leu Ala Arg Leu Gln Asn Glu 
545                 550                 555                 560 


Leu Asp Met Val Lys Ile Ser Lys Asp Pro Ser Lys Ile Pro Ser Trp 
                565                 570                 575     


Leu Lys Val Asn Lys Ile Tyr Tyr Pro Asp Phe Ile Val Pro Asp Pro 
            580                 585                 590         


Lys Lys Ala Ala Val Trp Glu Ile Thr Gly Ala Glu Phe Ser Lys Ser 
        595                 600                 605             


Glu Ala His Thr Ala Asp Gly Ile Ser Ile Arg Phe Pro Arg Cys Thr 
    610                 615                 620                 


Arg Ile Arg Asp Asp Lys Asp Trp Lys Ser Ala Thr Asn Leu Pro Gln 
625                 630                 635                 640 


Leu Lys Glu Leu Tyr Gln Leu Ser Lys Glu Lys Ala Asp Phe Thr Val 
                645                 650                 655     


Val Ala Gly Asp Glu Gly Ser Ser Thr Thr Gly Gly Ser Ser Glu Glu 
            660                 665                 670         


Asn Lys Gly Pro Ser Gly Ser Ala Val Ser Arg Lys Ala Pro Ser Lys 
        675                 680                 685             


Pro Ser Ala Ser Thr Lys Lys Ala Glu Gly Lys Leu Ser Asn Ser Asn 
    690                 695                 700                 


Ser Lys Asp Gly Asn Met Gln Thr Ala Lys Pro Ser Ala Met Lys Val 
705                 710                 715                 720 


Gly Glu Lys Leu Ala Thr Lys Ser Ser Pro Val Lys Val Gly Glu Lys 
                725                 730                 735     


Arg Lys Ala Ala Asp Glu Thr Leu Cys Gln Thr Lys Val Leu Leu Asp 
            740                 745                 750         


Ile Phe Thr Gly Val Arg Leu Tyr Leu Pro Pro Ser Thr Pro Asp Phe 
        755                 760                 765             


Ser Arg Leu Arg Arg Tyr Phe Val Ala Phe Asp Gly Asp Leu Val Gln 
    770                 775                 780                 


Glu Phe Asp Met Thr Ser Ala Thr His Val Leu Gly Ser Arg Asp Lys 
785                 790                 795                 800 


Asn Pro Ala Ala Gln Gln Val Ser Pro Glu Trp Ile Trp Ala Cys Ile 
                805                 810                 815     


Arg Lys Arg Arg Leu Val Ala Pro Cys 
            820                 825 


<210>  12
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full amino acid sequence of human DNA polymerase beta (PB) (M at 
       start of protein sequence is removed to fuse to Cas9)

<400>  12

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg 
            100                 105                 110         


Lys Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 
        115                 120                 125             


Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Gly 
    130                 135                 140                 


Asp Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp 
145                 150                 155                 160 


Ile Val Leu Asn Glu Val Lys Lys Val Asp Ser Glu Tyr Ile Ala Thr 
                165                 170                 175     


Val Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp 
            180                 185                 190         


Val Leu Leu Thr His Pro Ser Phe Thr Ser Glu Ser Thr Lys Gln Pro 
        195                 200                 205             


Lys Leu Leu His Gln Val Val Glu Gln Leu Gln Lys Val His Phe Ile 
    210                 215                 220                 


Thr Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln 
225                 230                 235                 240 


Leu Pro Ser Lys Asn Asp Glu Lys Glu Tyr Pro His Arg Arg Ile Asp 
                245                 250                 255     


Ile Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe 
            260                 265                 270         


Thr Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu 
        275                 280                 285             


Lys Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr 
    290                 295                 300                 


Gly Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Lys Asp Ile Phe 
305                 310                 315                 320 


Asp Tyr Ile Gln Trp Lys Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                325                 330                 335 


<210>  13
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full amino acid sequence of rat DNA polymerase beta (PB) (M at 
       start of protein sequence is removed to fuse to Cas9)

<400>  13

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Val Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Asn Phe Leu Thr Arg Val Thr Gly Ile Gly Pro Ser Ala Ala Arg 
            100                 105                 110         


Lys Leu Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 
        115                 120                 125             


Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Tyr Phe Glu 
    130                 135                 140                 


Asp Phe Glu Lys Arg Ile Pro Arg Glu Glu Met Leu Gln Met Gln Asp 
145                 150                 155                 160 


Ile Val Leu Asn Glu Val Lys Lys Leu Asp Pro Glu Tyr Ile Ala Thr 
                165                 170                 175     


Val Cys Gly Ser Phe Arg Arg Gly Ala Glu Ser Ser Gly Asp Met Asp 
            180                 185                 190         


Val Leu Leu Thr His Pro Asn Phe Thr Ser Glu Ser Ser Lys Gln Pro 
        195                 200                 205             


Lys Leu Leu His Arg Val Val Glu Gln Leu Gln Lys Val Arg Phe Ile 
    210                 215                 220                 


Thr Asp Thr Leu Ser Lys Gly Glu Thr Lys Phe Met Gly Val Cys Gln 
225                 230                 235                 240 


Leu Pro Ser Glu Asn Asp Glu Asn Glu Tyr Pro His Arg Arg Ile Asp 
                245                 250                 255     


Ile Arg Leu Ile Pro Lys Asp Gln Tyr Tyr Cys Gly Val Leu Tyr Phe 
            260                 265                 270         


Thr Gly Ser Asp Ile Phe Asn Lys Asn Met Arg Ala His Ala Leu Glu 
        275                 280                 285             


Lys Gly Phe Thr Ile Asn Glu Tyr Thr Ile Arg Pro Leu Gly Val Thr 
    290                 295                 300                 


Gly Val Ala Gly Glu Pro Leu Pro Val Asp Ser Glu Gln Asp Ile Phe 
305                 310                 315                 320 


Asp Tyr Ile Gln Trp Arg Tyr Arg Glu Pro Lys Asp Arg Ser Glu 
                325                 330                 335 


<210>  14
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EMX1 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  14
gagtccgagc agaagaagaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  15
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FANCF gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  15
ggaatccctt ctgcagcacc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  16
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-1 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  16
gaacacaaag catagactgc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  17
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-2 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  17
gagcaccaca ccctaaacta gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  18
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-3 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  18
ggaaacggat agttctgaaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  19
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-4 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  19
cttaactatt tgtattccac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  20
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-5 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  20
cttcccaagt gagaagccag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  21
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-6 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  21
ccagcccgct ggccctgtaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  22
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-7 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  22
cattccgtta ttttacatat gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  23
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-8 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  23
gtttccttta cagggccagc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  24
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-9 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  24
atacgcacag tttgacagat gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  25
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-10 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  25
gctggccctg taaaggaaac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  26
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-11 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  26
gcatgcgtgt gtgtttaagc gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  27
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-12 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  27
ttgggctgca gtaacttgaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  28
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-13 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  28
tctttcaagc aggtgattac gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  29
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-14 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  29
agtttccttt acagggccag gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  30
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-15 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  30
gaggtcgtgg ctgagcacaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  31
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-16 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  31
ggcctctatt gttggtagaa gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  32
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK3 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  32
ggcccagact gagcacgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  33
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK4 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  33
ggcactgcgg ctggaggtgg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  34
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNF2-1 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  34
gtcatcttag tcattacctg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  35
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNF2-2 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  35
cacacacact tagaatctgt gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  36
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNF2-3 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  36
acacacacac ttagaatctg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  37
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GJB2 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  37
ggacacgaag atcagctgca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  38
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADRB2 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  38
ccctttcctg cgtgacgtcg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  39
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYBPC3 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  39
ccctttcctg cgtgacgtcg gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  40
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAL 292 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  40
gaagtcgttg tcaaacagga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  41
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFA-1 gRNA


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Spacer

<400>  41
gatgtctgca ggccagatga gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  42
<211>  1713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, hPB(8kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  nCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(1702)
<223>  hPB(8kD)

<400>  42

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Arg Lys  Ala Pro Gln 
    1610                 1615                 1620             


Glu Thr  Leu Asn Gly Gly Ile  Thr Asp Met Leu Thr  Glu Leu Ala 
    1625                 1630                 1635             


Asn Phe  Glu Lys Asn Val Ser  Gln Ala Ile His Lys  Tyr Asn Ala 
    1640                 1645                 1650             


Tyr Arg  Lys Ala Ala Ser Val  Ile Ala Lys Tyr Pro  His Lys Ile 
    1655                 1660                 1665             


Lys Ser  Gly Ala Glu Ala Lys  Lys Leu Pro Gly Val  Gly Thr Lys 
    1670                 1675                 1680             


Ile Ala  Glu Lys Ile Asp Glu  Phe Leu Ala Thr Gly  Lys Leu Arg 
    1685                 1690                 1695             


Lys Leu  Glu Lys Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1700                 1705                 1710             


<210>  43
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, hPB(14kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  nCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(1756)
<223>  hPB(14kD)

<400>  43

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Arg Lys  Ala Pro Gln 
    1610                 1615                 1620             


Glu Thr  Leu Asn Gly Gly Ile  Thr Asp Met Leu Thr  Glu Leu Ala 
    1625                 1630                 1635             


Asn Phe  Glu Lys Asn Val Ser  Gln Ala Ile His Lys  Tyr Asn Ala 
    1640                 1645                 1650             


Tyr Arg  Lys Ala Ala Ser Val  Ile Ala Lys Tyr Pro  His Lys Ile 
    1655                 1660                 1665             


Lys Ser  Gly Ala Glu Ala Lys  Lys Leu Pro Gly Val  Gly Thr Lys 
    1670                 1675                 1680             


Ile Ala  Glu Lys Ile Asp Glu  Phe Leu Ala Thr Gly  Lys Leu Arg 
    1685                 1690                 1695             


Lys Leu  Glu Lys Ile Arg Gln  Asp Asp Thr Ser Ser  Ser Ile Asn 
    1700                 1705                 1710             


Phe Leu  Thr Arg Val Ser Gly  Ile Gly Pro Ser Ala  Ala Arg Lys 
    1715                 1720                 1725             


Phe Val  Asp Glu Gly Ile Lys  Thr Leu Glu Asp Leu  Arg Lys Asn 
    1730                 1735                 1740             


Glu Asp  Lys Leu Asn His His  Gln Arg Ile Gly Leu  Lys Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  44
<211>  1713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, rPB(8kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  nCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(1702)
<223>  rPB(8kD)

<400>  44

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Arg Lys  Ala Pro Gln 
    1610                 1615                 1620             


Glu Thr  Leu Asn Gly Gly Ile  Thr Asp Met Leu Val  Glu Leu Ala 
    1625                 1630                 1635             


Asn Phe  Glu Lys Asn Val Ser  Gln Ala Ile His Lys  Tyr Asn Ala 
    1640                 1645                 1650             


Tyr Arg  Lys Ala Ala Ser Val  Ile Ala Lys Tyr Pro  His Lys Ile 
    1655                 1660                 1665             


Lys Ser  Gly Ala Glu Ala Lys  Lys Leu Pro Gly Val  Gly Thr Lys 
    1670                 1675                 1680             


Ile Ala  Glu Lys Ile Asp Glu  Phe Leu Ala Thr Gly  Lys Leu Arg 
    1685                 1690                 1695             


Lys Leu  Glu Lys Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1700                 1705                 1710             


<210>  45
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, rPB(14kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  nCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(1756)
<223>  rPB(14kD)

<400>  45

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Arg Lys  Ala Pro Gln 
    1610                 1615                 1620             


Glu Thr  Leu Asn Gly Gly Ile  Thr Asp Met Leu Val  Glu Leu Ala 
    1625                 1630                 1635             


Asn Phe  Glu Lys Asn Val Ser  Gln Ala Ile His Lys  Tyr Asn Ala 
    1640                 1645                 1650             


Tyr Arg  Lys Ala Ala Ser Val  Ile Ala Lys Tyr Pro  His Lys Ile 
    1655                 1660                 1665             


Lys Ser  Gly Ala Glu Ala Lys  Lys Leu Pro Gly Val  Gly Thr Lys 
    1670                 1675                 1680             


Ile Ala  Glu Lys Ile Asp Glu  Phe Leu Ala Thr Gly  Lys Leu Arg 
    1685                 1690                 1695             


Lys Leu  Glu Lys Ile Arg Gln  Asp Asp Thr Ser Ser  Ser Ile Asn 
    1700                 1705                 1710             


Phe Leu  Thr Arg Val Thr Gly  Ile Gly Pro Ser Ala  Ala Arg Lys 
    1715                 1720                 1725             


Leu Val  Asp Glu Gly Ile Lys  Thr Leu Glu Asp Leu  Arg Lys Asn 
    1730                 1735                 1740             


Glu Asp  Lys Leu Asn His His  Gln Arg Ile Gly Leu  Lys Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  46
<211>  1713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, hPB(8kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  wtCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(1702)
<223>  hPB(8kD)

<400>  46

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Arg Lys  Ala Pro Gln 
    1610                 1615                 1620             


Glu Thr  Leu Asn Gly Gly Ile  Thr Asp Met Leu Thr  Glu Leu Ala 
    1625                 1630                 1635             


Asn Phe  Glu Lys Asn Val Ser  Gln Ala Ile His Lys  Tyr Asn Ala 
    1640                 1645                 1650             


Tyr Arg  Lys Ala Ala Ser Val  Ile Ala Lys Tyr Pro  His Lys Ile 
    1655                 1660                 1665             


Lys Ser  Gly Ala Glu Ala Lys  Lys Leu Pro Gly Val  Gly Thr Lys 
    1670                 1675                 1680             


Ile Ala  Glu Lys Ile Asp Glu  Phe Leu Ala Thr Gly  Lys Leu Arg 
    1685                 1690                 1695             


Lys Leu  Glu Lys Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1700                 1705                 1710             


<210>  47
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, hPB(14kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  wtCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(1756)
<223>  hPB(14kD)

<400>  47

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Arg Lys  Ala Pro Gln 
    1610                 1615                 1620             


Glu Thr  Leu Asn Gly Gly Ile  Thr Asp Met Leu Thr  Glu Leu Ala 
    1625                 1630                 1635             


Asn Phe  Glu Lys Asn Val Ser  Gln Ala Ile His Lys  Tyr Asn Ala 
    1640                 1645                 1650             


Tyr Arg  Lys Ala Ala Ser Val  Ile Ala Lys Tyr Pro  His Lys Ile 
    1655                 1660                 1665             


Lys Ser  Gly Ala Glu Ala Lys  Lys Leu Pro Gly Val  Gly Thr Lys 
    1670                 1675                 1680             


Ile Ala  Glu Lys Ile Asp Glu  Phe Leu Ala Thr Gly  Lys Leu Arg 
    1685                 1690                 1695             


Lys Leu  Glu Lys Ile Arg Gln  Asp Asp Thr Ser Ser  Ser Ile Asn 
    1700                 1705                 1710             


Phe Leu  Thr Arg Val Ser Gly  Ile Gly Pro Ser Ala  Ala Arg Lys 
    1715                 1720                 1725             


Phe Val  Asp Glu Gly Ile Lys  Thr Leu Glu Asp Leu  Arg Lys Asn 
    1730                 1735                 1740             


Glu Asp  Lys Leu Asn His His  Gln Arg Ile Gly Leu  Lys Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  48
<211>  1713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, rPB(8kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  wtCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(1702)
<223>  rPB(8kD)

<400>  48

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Arg Lys  Ala Pro Gln 
    1610                 1615                 1620             


Glu Thr  Leu Asn Gly Gly Ile  Thr Asp Met Leu Val  Glu Leu Ala 
    1625                 1630                 1635             


Asn Phe  Glu Lys Asn Val Ser  Gln Ala Ile His Lys  Tyr Asn Ala 
    1640                 1645                 1650             


Tyr Arg  Lys Ala Ala Ser Val  Ile Ala Lys Tyr Pro  His Lys Ile 
    1655                 1660                 1665             


Lys Ser  Gly Ala Glu Ala Lys  Lys Leu Pro Gly Val  Gly Thr Lys 
    1670                 1675                 1680             


Ile Ala  Glu Lys Ile Asp Glu  Phe Leu Ala Thr Gly  Lys Leu Arg 
    1685                 1690                 1695             


Lys Leu  Glu Lys Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1700                 1705                 1710             


<210>  49
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, rPB(14kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  wtCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(1756)
<223>  rPB(14kD)

<400>  49

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Arg Lys  Ala Pro Gln 
    1610                 1615                 1620             


Glu Thr  Leu Asn Gly Gly Ile  Thr Asp Met Leu Val  Glu Leu Ala 
    1625                 1630                 1635             


Asn Phe  Glu Lys Asn Val Ser  Gln Ala Ile His Lys  Tyr Asn Ala 
    1640                 1645                 1650             


Tyr Arg  Lys Ala Ala Ser Val  Ile Ala Lys Tyr Pro  His Lys Ile 
    1655                 1660                 1665             


Lys Ser  Gly Ala Glu Ala Lys  Lys Leu Pro Gly Val  Gly Thr Lys 
    1670                 1675                 1680             


Ile Ala  Glu Lys Ile Asp Glu  Phe Leu Ala Thr Gly  Lys Leu Arg 
    1685                 1690                 1695             


Lys Leu  Glu Lys Ile Arg Gln  Asp Asp Thr Ser Ser  Ser Ile Asn 
    1700                 1705                 1710             


Phe Leu  Thr Arg Val Thr Gly  Ile Gly Pro Ser Ala  Ala Arg Lys 
    1715                 1720                 1725             


Leu Val  Asp Glu Gly Ile Lys  Thr Leu Glu Asp Leu  Arg Lys Asn 
    1730                 1735                 1740             


Glu Asp  Lys Leu Asn His His  Gln Arg Ile Gly Leu  Lys Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  50
<211>  1713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXC, hPB(8kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (234)..(319)
<223>  hPB(8kD)

<220>
<221>  MISC_FEATURE
<222>  (336)..(1702)
<223>  nCas9

<400>  50

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Lys Arg Lys Ala Pro Gln 
225                 230                 235                 240 


Glu Thr Leu Asn Gly Gly Ile Thr Asp Met Leu Thr Glu Leu Ala Asn 
                245                 250                 255     


Phe Glu Lys Asn Val Ser Gln Ala Ile His Lys Tyr Asn Ala Tyr Arg 
            260                 265                 270         


Lys Ala Ala Ser Val Ile Ala Lys Tyr Pro His Lys Ile Lys Ser Gly 
        275                 280                 285             


Ala Glu Ala Lys Lys Leu Pro Gly Val Gly Thr Lys Ile Ala Glu Lys 
    290                 295                 300                 


Ile Asp Glu Phe Leu Ala Thr Gly Lys Leu Arg Lys Leu Glu Lys Ser 
305                 310                 315                 320 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Asp 
                325                 330                 335     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            340                 345                 350         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        355                 360                 365             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    370                 375                 380                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
385                 390                 395                 400 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                405                 410                 415     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            420                 425                 430         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        435                 440                 445             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    450                 455                 460                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
465                 470                 475                 480 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                485                 490                 495     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            500                 505                 510         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        515                 520                 525             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    530                 535                 540                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
545                 550                 555                 560 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                565                 570                 575     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            580                 585                 590         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        595                 600                 605             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    610                 615                 620                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
625                 630                 635                 640 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                645                 650                 655     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            660                 665                 670         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        675                 680                 685             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    690                 695                 700                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
705                 710                 715                 720 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                725                 730                 735     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            740                 745                 750         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        755                 760                 765             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    770                 775                 780                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
785                 790                 795                 800 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                805                 810                 815     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            820                 825                 830         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        835                 840                 845             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    850                 855                 860                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
865                 870                 875                 880 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                885                 890                 895     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            900                 905                 910         


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
        915                 920                 925             


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
    930                 935                 940                 


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
945                 950                 955                 960 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
                965                 970                 975     


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
            980                 985                 990         


Trp Gly Arg Leu Ser Arg Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln 
        995                 1000                 1005             


Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala 
    1010                 1015                 1020             


Asn Arg  Asn Phe Met Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe 
    1025                 1030                 1035             


Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser 
    1040                 1045                 1050             


Leu His  Glu His Ile Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys 
    1055                 1060                 1065             


Lys Gly  Ile Leu Gln Thr Val  Lys Val Val Asp Glu  Leu Val Lys 
    1070                 1075                 1080             


Val Met  Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
    1085                 1090                 1095             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1100                 1105                 1110             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1115                 1120                 1125             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1130                 1135                 1140             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1145                 1150                 1155             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1160                 1165                 1170             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1175                 1180                 1185             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1190                 1195                 1200             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1205                 1210                 1215             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1220                 1225                 1230             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1235                 1240                 1245             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1250                 1255                 1260             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1265                 1270                 1275             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1280                 1285                 1290             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1295                 1300                 1305             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1310                 1315                 1320             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1325                 1330                 1335             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1340                 1345                 1350             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1355                 1360                 1365             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1370                 1375                 1380             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1385                 1390                 1395             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1400                 1405                 1410             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1415                 1420                 1425             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1430                 1435                 1440             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1445                 1450                 1455             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1460                 1465                 1470             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1475                 1480                 1485             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1490                 1495                 1500             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1505                 1510                 1515             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1520                 1525                 1530             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1535                 1540                 1545             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1550                 1555                 1560             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1565                 1570                 1575             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1580                 1585                 1590             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1595                 1600                 1605             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1610                 1615                 1620             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1625                 1630                 1635             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1640                 1645                 1650             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1655                 1660                 1665             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1670                 1675                 1680             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1685                 1690                 1695             


Leu Gly  Gly Asp Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1700                 1705                 1710             


<210>  51
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXC, hPB(14kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (234)..(373)
<223>  hPB(14kD)

<220>
<221>  MISC_FEATURE
<222>  (390)..(1756)
<223>  nCas9

<400>  51

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Lys Arg Lys Ala Pro Gln 
225                 230                 235                 240 


Glu Thr Leu Asn Gly Gly Ile Thr Asp Met Leu Thr Glu Leu Ala Asn 
                245                 250                 255     


Phe Glu Lys Asn Val Ser Gln Ala Ile His Lys Tyr Asn Ala Tyr Arg 
            260                 265                 270         


Lys Ala Ala Ser Val Ile Ala Lys Tyr Pro His Lys Ile Lys Ser Gly 
        275                 280                 285             


Ala Glu Ala Lys Lys Leu Pro Gly Val Gly Thr Lys Ile Ala Glu Lys 
    290                 295                 300                 


Ile Asp Glu Phe Leu Ala Thr Gly Lys Leu Arg Lys Leu Glu Lys Ile 
305                 310                 315                 320 


Arg Gln Asp Asp Thr Ser Ser Ser Ile Asn Phe Leu Thr Arg Val Ser 
                325                 330                 335     


Gly Ile Gly Pro Ser Ala Ala Arg Lys Phe Val Asp Glu Gly Ile Lys 
            340                 345                 350         


Thr Leu Glu Asp Leu Arg Lys Asn Glu Asp Lys Leu Asn His His Gln 
        355                 360                 365             


Arg Ile Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  52
<211>  1713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXC, rPB(8kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (234)..(319)
<223>  rPB(8kD)

<220>
<221>  MISC_FEATURE
<222>  (336)..(1702)
<223>  nCas9

<400>  52

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Lys Arg Lys Ala Pro Gln 
225                 230                 235                 240 


Glu Thr Leu Asn Gly Gly Ile Thr Asp Met Leu Val Glu Leu Ala Asn 
                245                 250                 255     


Phe Glu Lys Asn Val Ser Gln Ala Ile His Lys Tyr Asn Ala Tyr Arg 
            260                 265                 270         


Lys Ala Ala Ser Val Ile Ala Lys Tyr Pro His Lys Ile Lys Ser Gly 
        275                 280                 285             


Ala Glu Ala Lys Lys Leu Pro Gly Val Gly Thr Lys Ile Ala Glu Lys 
    290                 295                 300                 


Ile Asp Glu Phe Leu Ala Thr Gly Lys Leu Arg Lys Leu Glu Lys Ser 
305                 310                 315                 320 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Asp 
                325                 330                 335     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            340                 345                 350         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        355                 360                 365             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    370                 375                 380                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
385                 390                 395                 400 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                405                 410                 415     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            420                 425                 430         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        435                 440                 445             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    450                 455                 460                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
465                 470                 475                 480 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                485                 490                 495     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            500                 505                 510         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        515                 520                 525             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    530                 535                 540                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
545                 550                 555                 560 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                565                 570                 575     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            580                 585                 590         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        595                 600                 605             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    610                 615                 620                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
625                 630                 635                 640 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                645                 650                 655     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            660                 665                 670         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        675                 680                 685             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    690                 695                 700                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
705                 710                 715                 720 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                725                 730                 735     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            740                 745                 750         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        755                 760                 765             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    770                 775                 780                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
785                 790                 795                 800 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                805                 810                 815     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            820                 825                 830         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        835                 840                 845             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    850                 855                 860                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
865                 870                 875                 880 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                885                 890                 895     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            900                 905                 910         


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
        915                 920                 925             


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
    930                 935                 940                 


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
945                 950                 955                 960 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
                965                 970                 975     


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
            980                 985                 990         


Trp Gly Arg Leu Ser Arg Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln 
        995                 1000                 1005             


Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala 
    1010                 1015                 1020             


Asn Arg  Asn Phe Met Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe 
    1025                 1030                 1035             


Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser 
    1040                 1045                 1050             


Leu His  Glu His Ile Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys 
    1055                 1060                 1065             


Lys Gly  Ile Leu Gln Thr Val  Lys Val Val Asp Glu  Leu Val Lys 
    1070                 1075                 1080             


Val Met  Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
    1085                 1090                 1095             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1100                 1105                 1110             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1115                 1120                 1125             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1130                 1135                 1140             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1145                 1150                 1155             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1160                 1165                 1170             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1175                 1180                 1185             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1190                 1195                 1200             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1205                 1210                 1215             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1220                 1225                 1230             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1235                 1240                 1245             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1250                 1255                 1260             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1265                 1270                 1275             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1280                 1285                 1290             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1295                 1300                 1305             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1310                 1315                 1320             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1325                 1330                 1335             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1340                 1345                 1350             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1355                 1360                 1365             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1370                 1375                 1380             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1385                 1390                 1395             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1400                 1405                 1410             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1415                 1420                 1425             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1430                 1435                 1440             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1445                 1450                 1455             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1460                 1465                 1470             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1475                 1480                 1485             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1490                 1495                 1500             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1505                 1510                 1515             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1520                 1525                 1530             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1535                 1540                 1545             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1550                 1555                 1560             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1565                 1570                 1575             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1580                 1585                 1590             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1595                 1600                 1605             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1610                 1615                 1620             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1625                 1630                 1635             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1640                 1645                 1650             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1655                 1660                 1665             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1670                 1675                 1680             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1685                 1690                 1695             


Leu Gly  Gly Asp Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1700                 1705                 1710             


<210>  53
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXC, rPB(14kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (234)..(373)
<223>  rPB(14kD)

<220>
<221>  MISC_FEATURE
<222>  (390)..(1756)
<223>  nCas9

<400>  53

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Lys Arg Lys Ala Pro Gln 
225                 230                 235                 240 


Glu Thr Leu Asn Gly Gly Ile Thr Asp Met Leu Val Glu Leu Ala Asn 
                245                 250                 255     


Phe Glu Lys Asn Val Ser Gln Ala Ile His Lys Tyr Asn Ala Tyr Arg 
            260                 265                 270         


Lys Ala Ala Ser Val Ile Ala Lys Tyr Pro His Lys Ile Lys Ser Gly 
        275                 280                 285             


Ala Glu Ala Lys Lys Leu Pro Gly Val Gly Thr Lys Ile Ala Glu Lys 
    290                 295                 300                 


Ile Asp Glu Phe Leu Ala Thr Gly Lys Leu Arg Lys Leu Glu Lys Ile 
305                 310                 315                 320 


Arg Gln Asp Asp Thr Ser Ser Ser Ile Asn Phe Leu Thr Arg Val Thr 
                325                 330                 335     


Gly Ile Gly Pro Ser Ala Ala Arg Lys Leu Val Asp Glu Gly Ile Lys 
            340                 345                 350         


Thr Leu Glu Asp Leu Arg Lys Asn Glu Asp Lys Leu Asn His His Gln 
        355                 360                 365             


Arg Ile Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  54
<211>  1713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAC, hPB(8kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(87)
<223>  hPB(8kD)

<220>
<221>  MISC_FEATURE
<222>  (92)..(319)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (336)..(1702)
<223>  nCas9

<400>  54

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ser Gly Gly Ser Ser Ser Glu Thr Gly 
                85                  90                  95      


Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu 
            100                 105                 110         


Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu 
        115                 120                 125             


Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr 
    130                 135                 140                 


Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe 
145                 150                 155                 160 


Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp 
                165                 170                 175     


Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu 
            180                 185                 190         


Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg 
        195                 200                 205             


Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu 
    210                 215                 220                 


Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly 
225                 230                 235                 240 


Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His 
                245                 250                 255     


Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu 
            260                 265                 270         


Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg 
        275                 280                 285             


Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His 
    290                 295                 300                 


Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser 
305                 310                 315                 320 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Asp 
                325                 330                 335     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            340                 345                 350         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        355                 360                 365             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    370                 375                 380                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
385                 390                 395                 400 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                405                 410                 415     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            420                 425                 430         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        435                 440                 445             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    450                 455                 460                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
465                 470                 475                 480 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                485                 490                 495     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            500                 505                 510         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        515                 520                 525             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    530                 535                 540                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
545                 550                 555                 560 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                565                 570                 575     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            580                 585                 590         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        595                 600                 605             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    610                 615                 620                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
625                 630                 635                 640 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                645                 650                 655     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            660                 665                 670         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        675                 680                 685             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    690                 695                 700                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
705                 710                 715                 720 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                725                 730                 735     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            740                 745                 750         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        755                 760                 765             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    770                 775                 780                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
785                 790                 795                 800 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                805                 810                 815     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            820                 825                 830         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        835                 840                 845             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    850                 855                 860                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
865                 870                 875                 880 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                885                 890                 895     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            900                 905                 910         


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
        915                 920                 925             


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
    930                 935                 940                 


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
945                 950                 955                 960 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
                965                 970                 975     


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
            980                 985                 990         


Trp Gly Arg Leu Ser Arg Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln 
        995                 1000                 1005             


Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala 
    1010                 1015                 1020             


Asn Arg  Asn Phe Met Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe 
    1025                 1030                 1035             


Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser 
    1040                 1045                 1050             


Leu His  Glu His Ile Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys 
    1055                 1060                 1065             


Lys Gly  Ile Leu Gln Thr Val  Lys Val Val Asp Glu  Leu Val Lys 
    1070                 1075                 1080             


Val Met  Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
    1085                 1090                 1095             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1100                 1105                 1110             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1115                 1120                 1125             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1130                 1135                 1140             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1145                 1150                 1155             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1160                 1165                 1170             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1175                 1180                 1185             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1190                 1195                 1200             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1205                 1210                 1215             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1220                 1225                 1230             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1235                 1240                 1245             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1250                 1255                 1260             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1265                 1270                 1275             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1280                 1285                 1290             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1295                 1300                 1305             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1310                 1315                 1320             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1325                 1330                 1335             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1340                 1345                 1350             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1355                 1360                 1365             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1370                 1375                 1380             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1385                 1390                 1395             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1400                 1405                 1410             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1415                 1420                 1425             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1430                 1435                 1440             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1445                 1450                 1455             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1460                 1465                 1470             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1475                 1480                 1485             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1490                 1495                 1500             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1505                 1510                 1515             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1520                 1525                 1530             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1535                 1540                 1545             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1550                 1555                 1560             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1565                 1570                 1575             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1580                 1585                 1590             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1595                 1600                 1605             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1610                 1615                 1620             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1625                 1630                 1635             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1640                 1645                 1650             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1655                 1660                 1665             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1670                 1675                 1680             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1685                 1690                 1695             


Leu Gly  Gly Asp Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1700                 1705                 1710             


<210>  55
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAC, hPB(14kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(141)
<223>  hPB(14kD)

<220>
<221>  MISC_FEATURE
<222>  (146)..(373)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (390)..(1756)
<223>  nCas9

<400>  55

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Thr Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Asn Phe Leu Thr Arg Val Ser Gly Ile Gly Pro Ser Ala Ala Arg 
            100                 105                 110         


Lys Phe Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 
        115                 120                 125             


Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Ser Gly Gly 
    130                 135                 140                 


Ser Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
145                 150                 155                 160 


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
                165                 170                 175     


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
            180                 185                 190         


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
        195                 200                 205             


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
    210                 215                 220                 


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
225                 230                 235                 240 


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
                245                 250                 255     


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
            260                 265                 270         


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
        275                 280                 285             


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
    290                 295                 300                 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
305                 310                 315                 320 


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
                325                 330                 335     


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
            340                 345                 350         


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
        355                 360                 365             


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  56
<211>  1713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAC, rPB(8kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(87)
<223>  rPB(8kD)

<220>
<221>  MISC_FEATURE
<222>  (92)..(319)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (336)..(1702)
<223>  nCas9

<400>  56

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Val Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ser Gly Gly Ser Ser Ser Glu Thr Gly 
                85                  90                  95      


Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu 
            100                 105                 110         


Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu 
        115                 120                 125             


Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr 
    130                 135                 140                 


Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe 
145                 150                 155                 160 


Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp 
                165                 170                 175     


Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu 
            180                 185                 190         


Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg 
        195                 200                 205             


Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu 
    210                 215                 220                 


Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly 
225                 230                 235                 240 


Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His 
                245                 250                 255     


Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu 
            260                 265                 270         


Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg 
        275                 280                 285             


Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His 
    290                 295                 300                 


Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser 
305                 310                 315                 320 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Asp 
                325                 330                 335     


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
            340                 345                 350         


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
        355                 360                 365             


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
    370                 375                 380                 


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
385                 390                 395                 400 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
                405                 410                 415     


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
            420                 425                 430         


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
        435                 440                 445             


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
    450                 455                 460                 


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
465                 470                 475                 480 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
                485                 490                 495     


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
            500                 505                 510         


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
        515                 520                 525             


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
    530                 535                 540                 


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
545                 550                 555                 560 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
                565                 570                 575     


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
            580                 585                 590         


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
        595                 600                 605             


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
    610                 615                 620                 


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
625                 630                 635                 640 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
                645                 650                 655     


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
            660                 665                 670         


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
        675                 680                 685             


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
    690                 695                 700                 


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
705                 710                 715                 720 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
                725                 730                 735     


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
            740                 745                 750         


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
        755                 760                 765             


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
    770                 775                 780                 


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
785                 790                 795                 800 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
                805                 810                 815     


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
            820                 825                 830         


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
        835                 840                 845             


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
    850                 855                 860                 


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
865                 870                 875                 880 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
                885                 890                 895     


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
            900                 905                 910         


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
        915                 920                 925             


His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu 
    930                 935                 940                 


Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe 
945                 950                 955                 960 


Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu 
                965                 970                 975     


Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly 
            980                 985                 990         


Trp Gly Arg Leu Ser Arg Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln 
        995                 1000                 1005             


Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala 
    1010                 1015                 1020             


Asn Arg  Asn Phe Met Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe 
    1025                 1030                 1035             


Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser 
    1040                 1045                 1050             


Leu His  Glu His Ile Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys 
    1055                 1060                 1065             


Lys Gly  Ile Leu Gln Thr Val  Lys Val Val Asp Glu  Leu Val Lys 
    1070                 1075                 1080             


Val Met  Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
    1085                 1090                 1095             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1100                 1105                 1110             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1115                 1120                 1125             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1130                 1135                 1140             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1145                 1150                 1155             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1160                 1165                 1170             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1175                 1180                 1185             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1190                 1195                 1200             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1205                 1210                 1215             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1220                 1225                 1230             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1235                 1240                 1245             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1250                 1255                 1260             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1265                 1270                 1275             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1280                 1285                 1290             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1295                 1300                 1305             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1310                 1315                 1320             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1325                 1330                 1335             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1340                 1345                 1350             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1355                 1360                 1365             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1370                 1375                 1380             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1385                 1390                 1395             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1400                 1405                 1410             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1415                 1420                 1425             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1430                 1435                 1440             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1445                 1450                 1455             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1460                 1465                 1470             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1475                 1480                 1485             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1490                 1495                 1500             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1505                 1510                 1515             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1520                 1525                 1530             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1535                 1540                 1545             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1550                 1555                 1560             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1565                 1570                 1575             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1580                 1585                 1590             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1595                 1600                 1605             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1610                 1615                 1620             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1625                 1630                 1635             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1640                 1645                 1650             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1655                 1660                 1665             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1670                 1675                 1680             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1685                 1690                 1695             


Leu Gly  Gly Asp Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1700                 1705                 1710             


<210>  57
<211>  1767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAC, rPB(14kD)


<220>
<221>  MISC_FEATURE
<222>  (1)..(141)
<223>  rPB(14kD)

<220>
<221>  MISC_FEATURE
<222>  (146)..(373)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (390)..(1756)
<223>  nCas9

<400>  57

Met Ser Lys Arg Lys Ala Pro Gln Glu Thr Leu Asn Gly Gly Ile Thr 
1               5                   10                  15      


Asp Met Leu Val Glu Leu Ala Asn Phe Glu Lys Asn Val Ser Gln Ala 
            20                  25                  30          


Ile His Lys Tyr Asn Ala Tyr Arg Lys Ala Ala Ser Val Ile Ala Lys 
        35                  40                  45              


Tyr Pro His Lys Ile Lys Ser Gly Ala Glu Ala Lys Lys Leu Pro Gly 
    50                  55                  60                  


Val Gly Thr Lys Ile Ala Glu Lys Ile Asp Glu Phe Leu Ala Thr Gly 
65                  70                  75                  80  


Lys Leu Arg Lys Leu Glu Lys Ile Arg Gln Asp Asp Thr Ser Ser Ser 
                85                  90                  95      


Ile Asn Phe Leu Thr Arg Val Thr Gly Ile Gly Pro Ser Ala Ala Arg 
            100                 105                 110         


Lys Leu Val Asp Glu Gly Ile Lys Thr Leu Glu Asp Leu Arg Lys Asn 
        115                 120                 125             


Glu Asp Lys Leu Asn His His Gln Arg Ile Gly Leu Lys Ser Gly Gly 
    130                 135                 140                 


Ser Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
145                 150                 155                 160 


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
                165                 170                 175     


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
            180                 185                 190         


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
        195                 200                 205             


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
    210                 215                 220                 


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
225                 230                 235                 240 


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
                245                 250                 255     


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
            260                 265                 270         


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
        275                 280                 285             


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
    290                 295                 300                 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
305                 310                 315                 320 


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
                325                 330                 335     


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
            340                 345                 350         


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
        355                 360                 365             


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
385                 390                 395                 400 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
                405                 410                 415     


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
            420                 425                 430         


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
        435                 440                 445             


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
    450                 455                 460                 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
465                 470                 475                 480 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
                485                 490                 495     


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
            500                 505                 510         


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
        515                 520                 525             


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
    530                 535                 540                 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
545                 550                 555                 560 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
                565                 570                 575     


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
            580                 585                 590         


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
        595                 600                 605             


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
    610                 615                 620                 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
625                 630                 635                 640 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
                645                 650                 655     


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
            660                 665                 670         


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
        675                 680                 685             


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
    690                 695                 700                 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
705                 710                 715                 720 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
                725                 730                 735     


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
            740                 745                 750         


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
        755                 760                 765             


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
    770                 775                 780                 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
785                 790                 795                 800 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
                805                 810                 815     


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
            820                 825                 830         


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
        835                 840                 845             


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
    850                 855                 860                 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
865                 870                 875                 880 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
                885                 890                 895     


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
            900                 905                 910         


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
        915                 920                 925             


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
    930                 935                 940                 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
945                 950                 955                 960 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
                965                 970                 975     


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
            980                 985                 990         


Asp Phe Leu Asp Asn Glu Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val 
        995                 1000                 1005             


Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg 
    1010                 1015                 1020             


Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp Lys Val  Met Lys Gln 
    1025                 1030                 1035             


Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys 
    1040                 1045                 1050             


Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln 
    1070                 1075                 1080             


Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys 
    1085                 1090                 1095             


Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu His Glu  His Ile Ala 
    1100                 1105                 1110             


Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr 
    1115                 1120                 1125             


Val Lys  Val Val Asp Glu Leu  Val Lys Val Met Gly  Arg His Lys 
    1130                 1135                 1140             


Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr 
    1145                 1150                 1155             


Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu 
    1160                 1165                 1170             


Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro 
    1175                 1180                 1185             


Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr 
    1190                 1195                 1200             


Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile 
    1205                 1210                 1215             


Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His Ile Val  Pro Gln Ser 
    1220                 1225                 1230             


Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser 
    1235                 1240                 1245             


Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val 
    1250                 1255                 1260             


Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys 
    1265                 1270                 1275             


Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg 
    1280                 1285                 1290             


Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln 
    1295                 1300                 1305             


Leu Val  Glu Thr Arg Gln Ile  Thr Lys His Val Ala  Gln Ile Leu 
    1310                 1315                 1320             


Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile 
    1325                 1330                 1335             


Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp 
    1340                 1345                 1350             


Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn 
    1355                 1360                 1365             


Tyr His  His Ala His Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr 
    1370                 1375                 1380             


Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr 
    1385                 1390                 1395             


Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser 
    1400                 1405                 1410             


Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser 
    1415                 1420                 1425             


Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly 
    1430                 1435                 1440             


Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly 
    1445                 1450                 1455             


Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys 
    1460                 1465                 1470             


Val Leu  Ser Met Pro Gln Val  Asn Ile Val Lys Lys  Thr Glu Val 
    1475                 1480                 1485             


Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn 
    1490                 1495                 1500             


Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys 
    1505                 1510                 1515             


Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val 
    1520                 1525                 1530             


Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val 
    1535                 1540                 1545             


Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu 
    1550                 1555                 1560             


Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val 
    1565                 1570                 1575             


Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu 
    1580                 1585                 1590             


Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu 
    1595                 1600                 1605             


Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe 
    1610                 1615                 1620             


Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu 
    1625                 1630                 1635             


Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu Gln His  Lys His Tyr 
    1640                 1645                 1650             


Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val 
    1655                 1660                 1665             


Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn 
    1670                 1675                 1680             


Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile 
    1685                 1690                 1695             


His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys 
    1700                 1705                 1710             


Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys 
    1715                 1720                 1725             


Glu Val  Leu Asp Ala Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu 
    1730                 1735                 1740             


Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly 
    1745                 1750                 1755             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1760                 1765         


<210>  58
<211>  2260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, hXRCC1


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  nCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(2249)
<223>  hXRCC1

<400>  58

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Gly Pro Glu Ile  Arg Leu Arg 
    1610                 1615                 1620             


His Val  Val Ser Cys Ser Ser  Gln Asp Ser Thr His  Cys Ala Glu 
    1625                 1630                 1635             


Asn Leu  Leu Lys Ala Asp Thr  Tyr Arg Lys Trp Arg  Ala Ala Lys 
    1640                 1645                 1650             


Ala Gly  Glu Lys Thr Ile Ser  Val Val Leu Gln Leu  Glu Lys Glu 
    1655                 1660                 1665             


Glu Gln  Ile His Ser Val Asp  Ile Gly Asn Asp Gly  Ser Ala Phe 
    1670                 1675                 1680             


Val Glu  Val Leu Val Gly Ser  Ser Ala Gly Gly Ala  Gly Glu Gln 
    1685                 1690                 1695             


Asp Tyr  Glu Val Leu Leu Val  Thr Ser Ser Phe Met  Ser Pro Ser 
    1700                 1705                 1710             


Glu Ser  Arg Ser Gly Ser Asn  Pro Asn Arg Val Arg  Met Phe Gly 
    1715                 1720                 1725             


Pro Asp  Lys Leu Val Arg Ala  Ala Ala Glu Lys Arg  Trp Asp Arg 
    1730                 1735                 1740             


Val Lys  Ile Val Cys Ser Gln  Pro Tyr Ser Lys Asp  Ser Pro Phe 
    1745                 1750                 1755             


Gly Leu  Ser Phe Val Arg Phe  His Ser Pro Pro Asp  Lys Asp Glu 
    1760                 1765                 1770             


Ala Glu  Ala Pro Ser Gln Lys  Val Thr Val Thr Lys  Leu Gly Gln 
    1775                 1780                 1785             


Phe Arg  Val Lys Glu Glu Asp  Glu Ser Ala Asn Ser  Leu Arg Pro 
    1790                 1795                 1800             


Gly Ala  Leu Phe Phe Ser Arg  Ile Asn Lys Thr Ser  Pro Val Thr 
    1805                 1810                 1815             


Ala Ser  Asp Pro Ala Gly Pro  Ser Tyr Ala Ala Ala  Thr Leu Gln 
    1820                 1825                 1830             


Ala Ser  Ser Ala Ala Ser Ser  Ala Ser Pro Val Ser  Arg Ala Ile 
    1835                 1840                 1845             


Gly Ser  Thr Ser Lys Pro Gln  Glu Ser Pro Lys Gly  Lys Arg Lys 
    1850                 1855                 1860             


Leu Asp  Leu Asn Gln Glu Glu  Lys Lys Thr Pro Ser  Lys Pro Pro 
    1865                 1870                 1875             


Ala Gln  Leu Ser Pro Ser Val  Pro Lys Arg Pro Lys  Leu Pro Ala 
    1880                 1885                 1890             


Pro Thr  Arg Thr Pro Ala Thr  Ala Pro Val Pro Ala  Arg Ala Gln 
    1895                 1900                 1905             


Gly Ala  Val Thr Gly Lys Pro  Arg Gly Glu Gly Thr  Glu Pro Arg 
    1910                 1915                 1920             


Arg Pro  Arg Ala Gly Pro Glu  Glu Leu Gly Lys Ile  Leu Gln Gly 
    1925                 1930                 1935             


Val Val  Val Val Leu Ser Gly  Phe Gln Asn Pro Phe  Arg Ser Glu 
    1940                 1945                 1950             


Leu Arg  Asp Lys Ala Leu Glu  Leu Gly Ala Lys Tyr  Arg Pro Asp 
    1955                 1960                 1965             


Trp Thr  Arg Asp Ser Thr His  Leu Ile Cys Ala Phe  Ala Asn Thr 
    1970                 1975                 1980             


Pro Lys  Tyr Ser Gln Val Leu  Gly Leu Gly Gly Arg  Ile Val Arg 
    1985                 1990                 1995             


Lys Glu  Trp Val Leu Asp Cys  His Arg Met Arg Arg  Arg Leu Pro 
    2000                 2005                 2010             


Ser Gln  Arg Tyr Leu Met Ala  Gly Pro Gly Ser Ser  Ser Glu Glu 
    2015                 2020                 2025             


Asp Glu  Ala Ser His Ser Gly  Gly Ser Gly Asp Glu  Ala Pro Lys 
    2030                 2035                 2040             


Leu Pro  Gln Lys Gln Pro Gln  Thr Lys Thr Lys Pro  Thr Gln Ala 
    2045                 2050                 2055             


Ala Gly  Pro Ser Ser Pro Gln  Lys Pro Pro Thr Pro  Glu Glu Thr 
    2060                 2065                 2070             


Lys Ala  Ala Ser Pro Val Leu  Gln Glu Asp Ile Asp  Ile Glu Gly 
    2075                 2080                 2085             


Val Gln  Ser Glu Gly Gln Asp  Asn Gly Ala Glu Asp  Ser Gly Asp 
    2090                 2095                 2100             


Thr Glu  Asp Glu Leu Arg Arg  Val Ala Glu Gln Lys  Glu His Arg 
    2105                 2110                 2115             


Leu Pro  Pro Gly Gln Glu Glu  Asn Gly Glu Asp Pro  Tyr Ala Gly 
    2120                 2125                 2130             


Ser Thr  Asp Glu Asn Thr Asp  Ser Glu Glu His Gln  Glu Pro Pro 
    2135                 2140                 2145             


Asp Leu  Pro Val Pro Glu Leu  Pro Asp Phe Phe Gln  Gly Lys His 
    2150                 2155                 2160             


Phe Phe  Leu Tyr Gly Glu Phe  Pro Gly Asp Glu Arg  Arg Lys Leu 
    2165                 2170                 2175             


Ile Arg  Tyr Val Thr Ala Phe  Asn Gly Glu Leu Glu  Asp Tyr Met 
    2180                 2185                 2190             


Ser Asp  Arg Val Gln Phe Val  Ile Thr Ala Gln Glu  Trp Asp Pro 
    2195                 2200                 2205             


Ser Phe  Glu Glu Ala Leu Met  Asp Asn Pro Ser Leu  Ala Phe Val 
    2210                 2215                 2220             


Arg Pro  Arg Trp Ile Tyr Ser  Cys Asn Glu Lys Gln  Lys Leu Leu 
    2225                 2230                 2235             


Pro His  Gln Leu Tyr Gly Val  Val Pro Gln Ala Ser  Gly Gly Ser 
    2240                 2245                 2250             


Pro Lys  Lys Lys Arg Lys Val  
    2255                 2260 


<210>  59
<211>  2260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, hXRCC1


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  wtCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(2249)
<223>  hXRCC1

<400>  59

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Gly Pro Glu Ile  Arg Leu Arg 
    1610                 1615                 1620             


His Val  Val Ser Cys Ser Ser  Gln Asp Ser Thr His  Cys Ala Glu 
    1625                 1630                 1635             


Asn Leu  Leu Lys Ala Asp Thr  Tyr Arg Lys Trp Arg  Ala Ala Lys 
    1640                 1645                 1650             


Ala Gly  Glu Lys Thr Ile Ser  Val Val Leu Gln Leu  Glu Lys Glu 
    1655                 1660                 1665             


Glu Gln  Ile His Ser Val Asp  Ile Gly Asn Asp Gly  Ser Ala Phe 
    1670                 1675                 1680             


Val Glu  Val Leu Val Gly Ser  Ser Ala Gly Gly Ala  Gly Glu Gln 
    1685                 1690                 1695             


Asp Tyr  Glu Val Leu Leu Val  Thr Ser Ser Phe Met  Ser Pro Ser 
    1700                 1705                 1710             


Glu Ser  Arg Ser Gly Ser Asn  Pro Asn Arg Val Arg  Met Phe Gly 
    1715                 1720                 1725             


Pro Asp  Lys Leu Val Arg Ala  Ala Ala Glu Lys Arg  Trp Asp Arg 
    1730                 1735                 1740             


Val Lys  Ile Val Cys Ser Gln  Pro Tyr Ser Lys Asp  Ser Pro Phe 
    1745                 1750                 1755             


Gly Leu  Ser Phe Val Arg Phe  His Ser Pro Pro Asp  Lys Asp Glu 
    1760                 1765                 1770             


Ala Glu  Ala Pro Ser Gln Lys  Val Thr Val Thr Lys  Leu Gly Gln 
    1775                 1780                 1785             


Phe Arg  Val Lys Glu Glu Asp  Glu Ser Ala Asn Ser  Leu Arg Pro 
    1790                 1795                 1800             


Gly Ala  Leu Phe Phe Ser Arg  Ile Asn Lys Thr Ser  Pro Val Thr 
    1805                 1810                 1815             


Ala Ser  Asp Pro Ala Gly Pro  Ser Tyr Ala Ala Ala  Thr Leu Gln 
    1820                 1825                 1830             


Ala Ser  Ser Ala Ala Ser Ser  Ala Ser Pro Val Ser  Arg Ala Ile 
    1835                 1840                 1845             


Gly Ser  Thr Ser Lys Pro Gln  Glu Ser Pro Lys Gly  Lys Arg Lys 
    1850                 1855                 1860             


Leu Asp  Leu Asn Gln Glu Glu  Lys Lys Thr Pro Ser  Lys Pro Pro 
    1865                 1870                 1875             


Ala Gln  Leu Ser Pro Ser Val  Pro Lys Arg Pro Lys  Leu Pro Ala 
    1880                 1885                 1890             


Pro Thr  Arg Thr Pro Ala Thr  Ala Pro Val Pro Ala  Arg Ala Gln 
    1895                 1900                 1905             


Gly Ala  Val Thr Gly Lys Pro  Arg Gly Glu Gly Thr  Glu Pro Arg 
    1910                 1915                 1920             


Arg Pro  Arg Ala Gly Pro Glu  Glu Leu Gly Lys Ile  Leu Gln Gly 
    1925                 1930                 1935             


Val Val  Val Val Leu Ser Gly  Phe Gln Asn Pro Phe  Arg Ser Glu 
    1940                 1945                 1950             


Leu Arg  Asp Lys Ala Leu Glu  Leu Gly Ala Lys Tyr  Arg Pro Asp 
    1955                 1960                 1965             


Trp Thr  Arg Asp Ser Thr His  Leu Ile Cys Ala Phe  Ala Asn Thr 
    1970                 1975                 1980             


Pro Lys  Tyr Ser Gln Val Leu  Gly Leu Gly Gly Arg  Ile Val Arg 
    1985                 1990                 1995             


Lys Glu  Trp Val Leu Asp Cys  His Arg Met Arg Arg  Arg Leu Pro 
    2000                 2005                 2010             


Ser Gln  Arg Tyr Leu Met Ala  Gly Pro Gly Ser Ser  Ser Glu Glu 
    2015                 2020                 2025             


Asp Glu  Ala Ser His Ser Gly  Gly Ser Gly Asp Glu  Ala Pro Lys 
    2030                 2035                 2040             


Leu Pro  Gln Lys Gln Pro Gln  Thr Lys Thr Lys Pro  Thr Gln Ala 
    2045                 2050                 2055             


Ala Gly  Pro Ser Ser Pro Gln  Lys Pro Pro Thr Pro  Glu Glu Thr 
    2060                 2065                 2070             


Lys Ala  Ala Ser Pro Val Leu  Gln Glu Asp Ile Asp  Ile Glu Gly 
    2075                 2080                 2085             


Val Gln  Ser Glu Gly Gln Asp  Asn Gly Ala Glu Asp  Ser Gly Asp 
    2090                 2095                 2100             


Thr Glu  Asp Glu Leu Arg Arg  Val Ala Glu Gln Lys  Glu His Arg 
    2105                 2110                 2115             


Leu Pro  Pro Gly Gln Glu Glu  Asn Gly Glu Asp Pro  Tyr Ala Gly 
    2120                 2125                 2130             


Ser Thr  Asp Glu Asn Thr Asp  Ser Glu Glu His Gln  Glu Pro Pro 
    2135                 2140                 2145             


Asp Leu  Pro Val Pro Glu Leu  Pro Asp Phe Phe Gln  Gly Lys His 
    2150                 2155                 2160             


Phe Phe  Leu Tyr Gly Glu Phe  Pro Gly Asp Glu Arg  Arg Lys Leu 
    2165                 2170                 2175             


Ile Arg  Tyr Val Thr Ala Phe  Asn Gly Glu Leu Glu  Asp Tyr Met 
    2180                 2185                 2190             


Ser Asp  Arg Val Gln Phe Val  Ile Thr Ala Gln Glu  Trp Asp Pro 
    2195                 2200                 2205             


Ser Phe  Glu Glu Ala Leu Met  Asp Asn Pro Ser Leu  Ala Phe Val 
    2210                 2215                 2220             


Arg Pro  Arg Trp Ile Tyr Ser  Cys Asn Glu Lys Gln  Lys Leu Leu 
    2225                 2230                 2235             


Pro His  Gln Leu Tyr Gly Val  Val Pro Gln Ala Ser  Gly Gly Ser 
    2240                 2245                 2250             


Pro Lys  Lys Lys Arg Lys Val  
    2255                 2260 


<210>  60
<211>  2260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXC, hXRCC1


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (234)..(866)
<223>  hXRCC1

<220>
<221>  MISC_FEATURE
<222>  (883)..(2249)
<223>  nCas9

<400>  60

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Gly Pro Glu Ile Arg Leu Arg 
225                 230                 235                 240 


His Val Val Ser Cys Ser Ser Gln Asp Ser Thr His Cys Ala Glu Asn 
                245                 250                 255     


Leu Leu Lys Ala Asp Thr Tyr Arg Lys Trp Arg Ala Ala Lys Ala Gly 
            260                 265                 270         


Glu Lys Thr Ile Ser Val Val Leu Gln Leu Glu Lys Glu Glu Gln Ile 
        275                 280                 285             


His Ser Val Asp Ile Gly Asn Asp Gly Ser Ala Phe Val Glu Val Leu 
    290                 295                 300                 


Val Gly Ser Ser Ala Gly Gly Ala Gly Glu Gln Asp Tyr Glu Val Leu 
305                 310                 315                 320 


Leu Val Thr Ser Ser Phe Met Ser Pro Ser Glu Ser Arg Ser Gly Ser 
                325                 330                 335     


Asn Pro Asn Arg Val Arg Met Phe Gly Pro Asp Lys Leu Val Arg Ala 
            340                 345                 350         


Ala Ala Glu Lys Arg Trp Asp Arg Val Lys Ile Val Cys Ser Gln Pro 
        355                 360                 365             


Tyr Ser Lys Asp Ser Pro Phe Gly Leu Ser Phe Val Arg Phe His Ser 
    370                 375                 380                 


Pro Pro Asp Lys Asp Glu Ala Glu Ala Pro Ser Gln Lys Val Thr Val 
385                 390                 395                 400 


Thr Lys Leu Gly Gln Phe Arg Val Lys Glu Glu Asp Glu Ser Ala Asn 
                405                 410                 415     


Ser Leu Arg Pro Gly Ala Leu Phe Phe Ser Arg Ile Asn Lys Thr Ser 
            420                 425                 430         


Pro Val Thr Ala Ser Asp Pro Ala Gly Pro Ser Tyr Ala Ala Ala Thr 
        435                 440                 445             


Leu Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Pro Val Ser Arg Ala 
    450                 455                 460                 


Ile Gly Ser Thr Ser Lys Pro Gln Glu Ser Pro Lys Gly Lys Arg Lys 
465                 470                 475                 480 


Leu Asp Leu Asn Gln Glu Glu Lys Lys Thr Pro Ser Lys Pro Pro Ala 
                485                 490                 495     


Gln Leu Ser Pro Ser Val Pro Lys Arg Pro Lys Leu Pro Ala Pro Thr 
            500                 505                 510         


Arg Thr Pro Ala Thr Ala Pro Val Pro Ala Arg Ala Gln Gly Ala Val 
        515                 520                 525             


Thr Gly Lys Pro Arg Gly Glu Gly Thr Glu Pro Arg Arg Pro Arg Ala 
    530                 535                 540                 


Gly Pro Glu Glu Leu Gly Lys Ile Leu Gln Gly Val Val Val Val Leu 
545                 550                 555                 560 


Ser Gly Phe Gln Asn Pro Phe Arg Ser Glu Leu Arg Asp Lys Ala Leu 
                565                 570                 575     


Glu Leu Gly Ala Lys Tyr Arg Pro Asp Trp Thr Arg Asp Ser Thr His 
            580                 585                 590         


Leu Ile Cys Ala Phe Ala Asn Thr Pro Lys Tyr Ser Gln Val Leu Gly 
        595                 600                 605             


Leu Gly Gly Arg Ile Val Arg Lys Glu Trp Val Leu Asp Cys His Arg 
    610                 615                 620                 


Met Arg Arg Arg Leu Pro Ser Gln Arg Tyr Leu Met Ala Gly Pro Gly 
625                 630                 635                 640 


Ser Ser Ser Glu Glu Asp Glu Ala Ser His Ser Gly Gly Ser Gly Asp 
                645                 650                 655     


Glu Ala Pro Lys Leu Pro Gln Lys Gln Pro Gln Thr Lys Thr Lys Pro 
            660                 665                 670         


Thr Gln Ala Ala Gly Pro Ser Ser Pro Gln Lys Pro Pro Thr Pro Glu 
        675                 680                 685             


Glu Thr Lys Ala Ala Ser Pro Val Leu Gln Glu Asp Ile Asp Ile Glu 
    690                 695                 700                 


Gly Val Gln Ser Glu Gly Gln Asp Asn Gly Ala Glu Asp Ser Gly Asp 
705                 710                 715                 720 


Thr Glu Asp Glu Leu Arg Arg Val Ala Glu Gln Lys Glu His Arg Leu 
                725                 730                 735     


Pro Pro Gly Gln Glu Glu Asn Gly Glu Asp Pro Tyr Ala Gly Ser Thr 
            740                 745                 750         


Asp Glu Asn Thr Asp Ser Glu Glu His Gln Glu Pro Pro Asp Leu Pro 
        755                 760                 765             


Val Pro Glu Leu Pro Asp Phe Phe Gln Gly Lys His Phe Phe Leu Tyr 
    770                 775                 780                 


Gly Glu Phe Pro Gly Asp Glu Arg Arg Lys Leu Ile Arg Tyr Val Thr 
785                 790                 795                 800 


Ala Phe Asn Gly Glu Leu Glu Asp Tyr Met Ser Asp Arg Val Gln Phe 
                805                 810                 815     


Val Ile Thr Ala Gln Glu Trp Asp Pro Ser Phe Glu Glu Ala Leu Met 
            820                 825                 830         


Asp Asn Pro Ser Leu Ala Phe Val Arg Pro Arg Trp Ile Tyr Ser Cys 
        835                 840                 845             


Asn Glu Lys Gln Lys Leu Leu Pro His Gln Leu Tyr Gly Val Val Pro 
    850                 855                 860                 


Gln Ala Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
865                 870                 875                 880 


Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser 
                885                 890                 895     


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
            900                 905                 910         


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
        915                 920                 925             


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    930                 935                 940                 


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
945                 950                 955                 960 


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
                965                 970                 975     


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
            980                 985                 990         


Lys His Glu Arg His Pro Ile Phe  Gly Asn Ile Val Asp  Glu Val Ala 
        995                 1000                 1005             


Tyr His  Glu Lys Tyr Pro Thr  Ile Tyr His Leu Arg  Lys Lys Leu 
    1010                 1015                 1020             


Val Asp  Ser Thr Asp Lys Ala  Asp Leu Arg Leu Ile  Tyr Leu Ala 
    1025                 1030                 1035             


Leu Ala  His Met Ile Lys Phe  Arg Gly His Phe Leu  Ile Glu Gly 
    1040                 1045                 1050             


Asp Leu  Asn Pro Asp Asn Ser  Asp Val Asp Lys Leu  Phe Ile Gln 
    1055                 1060                 1065             


Leu Val  Gln Thr Tyr Asn Gln  Leu Phe Glu Glu Asn  Pro Ile Asn 
    1070                 1075                 1080             


Ala Ser  Gly Val Asp Ala Lys  Ala Ile Leu Ser Ala  Arg Leu Ser 
    1085                 1090                 1095             


Lys Ser  Arg Arg Leu Glu Asn  Leu Ile Ala Gln Leu  Pro Gly Glu 
    1100                 1105                 1110             


Lys Lys  Asn Gly Leu Phe Gly  Asn Leu Ile Ala Leu  Ser Leu Gly 
    1115                 1120                 1125             


Leu Thr  Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
    1130                 1135                 1140             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1145                 1150                 1155             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1160                 1165                 1170             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1175                 1180                 1185             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1190                 1195                 1200             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1205                 1210                 1215             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1220                 1225                 1230             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1235                 1240                 1245             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1250                 1255                 1260             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1265                 1270                 1275             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1280                 1285                 1290             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1295                 1300                 1305             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1310                 1315                 1320             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1325                 1330                 1335             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1340                 1345                 1350             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1355                 1360                 1365             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1370                 1375                 1380             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1385                 1390                 1395             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1400                 1405                 1410             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1415                 1420                 1425             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1430                 1435                 1440             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1445                 1450                 1455             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1460                 1465                 1470             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1475                 1480                 1485             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1490                 1495                 1500             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1505                 1510                 1515             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1520                 1525                 1530             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1535                 1540                 1545             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1550                 1555                 1560             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1565                 1570                 1575             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1580                 1585                 1590             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1595                 1600                 1605             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1610                 1615                 1620             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1625                 1630                 1635             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1640                 1645                 1650             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1655                 1660                 1665             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1670                 1675                 1680             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1685                 1690                 1695             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1700                 1705                 1710             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1715                 1720                 1725             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1730                 1735                 1740             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1745                 1750                 1755             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1760                 1765                 1770             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1775                 1780                 1785             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1790                 1795                 1800             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1805                 1810                 1815             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1820                 1825                 1830             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1835                 1840                 1845             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1850                 1855                 1860             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1865                 1870                 1875             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1880                 1885                 1890             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1895                 1900                 1905             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1910                 1915                 1920             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1925                 1930                 1935             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1940                 1945                 1950             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1955                 1960                 1965             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1970                 1975                 1980             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1985                 1990                 1995             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    2000                 2005                 2010             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    2015                 2020                 2025             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    2030                 2035                 2040             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    2045                 2050                 2055             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    2060                 2065                 2070             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    2075                 2080                 2085             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    2090                 2095                 2100             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    2105                 2110                 2115             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    2120                 2125                 2130             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2135                 2140                 2145             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2150                 2155                 2160             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2165                 2170                 2175             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2180                 2185                 2190             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    2195                 2200                 2205             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    2210                 2215                 2220             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2225                 2230                 2235             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    2240                 2245                 2250             


Pro Lys  Lys Lys Arg Lys Val  
    2255                 2260 


<210>  61
<211>  2260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAC, hXRCC1


<220>
<221>  MISC_FEATURE
<222>  (1)..(634)
<223>  hXRCC1

<220>
<221>  MISC_FEATURE
<222>  (639)..(866)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (883)..(2249)
<223>  nCas9

<400>  61

Met Gly Pro Glu Ile Arg Leu Arg His Val Val Ser Cys Ser Ser Gln 
1               5                   10                  15      


Asp Ser Thr His Cys Ala Glu Asn Leu Leu Lys Ala Asp Thr Tyr Arg 
            20                  25                  30          


Lys Trp Arg Ala Ala Lys Ala Gly Glu Lys Thr Ile Ser Val Val Leu 
        35                  40                  45              


Gln Leu Glu Lys Glu Glu Gln Ile His Ser Val Asp Ile Gly Asn Asp 
    50                  55                  60                  


Gly Ser Ala Phe Val Glu Val Leu Val Gly Ser Ser Ala Gly Gly Ala 
65                  70                  75                  80  


Gly Glu Gln Asp Tyr Glu Val Leu Leu Val Thr Ser Ser Phe Met Ser 
                85                  90                  95      


Pro Ser Glu Ser Arg Ser Gly Ser Asn Pro Asn Arg Val Arg Met Phe 
            100                 105                 110         


Gly Pro Asp Lys Leu Val Arg Ala Ala Ala Glu Lys Arg Trp Asp Arg 
        115                 120                 125             


Val Lys Ile Val Cys Ser Gln Pro Tyr Ser Lys Asp Ser Pro Phe Gly 
    130                 135                 140                 


Leu Ser Phe Val Arg Phe His Ser Pro Pro Asp Lys Asp Glu Ala Glu 
145                 150                 155                 160 


Ala Pro Ser Gln Lys Val Thr Val Thr Lys Leu Gly Gln Phe Arg Val 
                165                 170                 175     


Lys Glu Glu Asp Glu Ser Ala Asn Ser Leu Arg Pro Gly Ala Leu Phe 
            180                 185                 190         


Phe Ser Arg Ile Asn Lys Thr Ser Pro Val Thr Ala Ser Asp Pro Ala 
        195                 200                 205             


Gly Pro Ser Tyr Ala Ala Ala Thr Leu Gln Ala Ser Ser Ala Ala Ser 
    210                 215                 220                 


Ser Ala Ser Pro Val Ser Arg Ala Ile Gly Ser Thr Ser Lys Pro Gln 
225                 230                 235                 240 


Glu Ser Pro Lys Gly Lys Arg Lys Leu Asp Leu Asn Gln Glu Glu Lys 
                245                 250                 255     


Lys Thr Pro Ser Lys Pro Pro Ala Gln Leu Ser Pro Ser Val Pro Lys 
            260                 265                 270         


Arg Pro Lys Leu Pro Ala Pro Thr Arg Thr Pro Ala Thr Ala Pro Val 
        275                 280                 285             


Pro Ala Arg Ala Gln Gly Ala Val Thr Gly Lys Pro Arg Gly Glu Gly 
    290                 295                 300                 


Thr Glu Pro Arg Arg Pro Arg Ala Gly Pro Glu Glu Leu Gly Lys Ile 
305                 310                 315                 320 


Leu Gln Gly Val Val Val Val Leu Ser Gly Phe Gln Asn Pro Phe Arg 
                325                 330                 335     


Ser Glu Leu Arg Asp Lys Ala Leu Glu Leu Gly Ala Lys Tyr Arg Pro 
            340                 345                 350         


Asp Trp Thr Arg Asp Ser Thr His Leu Ile Cys Ala Phe Ala Asn Thr 
        355                 360                 365             


Pro Lys Tyr Ser Gln Val Leu Gly Leu Gly Gly Arg Ile Val Arg Lys 
    370                 375                 380                 


Glu Trp Val Leu Asp Cys His Arg Met Arg Arg Arg Leu Pro Ser Gln 
385                 390                 395                 400 


Arg Tyr Leu Met Ala Gly Pro Gly Ser Ser Ser Glu Glu Asp Glu Ala 
                405                 410                 415     


Ser His Ser Gly Gly Ser Gly Asp Glu Ala Pro Lys Leu Pro Gln Lys 
            420                 425                 430         


Gln Pro Gln Thr Lys Thr Lys Pro Thr Gln Ala Ala Gly Pro Ser Ser 
        435                 440                 445             


Pro Gln Lys Pro Pro Thr Pro Glu Glu Thr Lys Ala Ala Ser Pro Val 
    450                 455                 460                 


Leu Gln Glu Asp Ile Asp Ile Glu Gly Val Gln Ser Glu Gly Gln Asp 
465                 470                 475                 480 


Asn Gly Ala Glu Asp Ser Gly Asp Thr Glu Asp Glu Leu Arg Arg Val 
                485                 490                 495     


Ala Glu Gln Lys Glu His Arg Leu Pro Pro Gly Gln Glu Glu Asn Gly 
            500                 505                 510         


Glu Asp Pro Tyr Ala Gly Ser Thr Asp Glu Asn Thr Asp Ser Glu Glu 
        515                 520                 525             


His Gln Glu Pro Pro Asp Leu Pro Val Pro Glu Leu Pro Asp Phe Phe 
    530                 535                 540                 


Gln Gly Lys His Phe Phe Leu Tyr Gly Glu Phe Pro Gly Asp Glu Arg 
545                 550                 555                 560 


Arg Lys Leu Ile Arg Tyr Val Thr Ala Phe Asn Gly Glu Leu Glu Asp 
                565                 570                 575     


Tyr Met Ser Asp Arg Val Gln Phe Val Ile Thr Ala Gln Glu Trp Asp 
            580                 585                 590         


Pro Ser Phe Glu Glu Ala Leu Met Asp Asn Pro Ser Leu Ala Phe Val 
        595                 600                 605             


Arg Pro Arg Trp Ile Tyr Ser Cys Asn Glu Lys Gln Lys Leu Leu Pro 
    610                 615                 620                 


His Gln Leu Tyr Gly Val Val Pro Gln Ala Ser Gly Gly Ser Ser Ser 
625                 630                 635                 640 


Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu 
                645                 650                 655     


Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu 
            660                 665                 670         


Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp 
        675                 680                 685             


Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile 
    690                 695                 700                 


Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser 
705                 710                 715                 720 


Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala 
                725                 730                 735     


Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr 
            740                 745                 750         


Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu 
        755                 760                 765             


Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln 
    770                 775                 780                 


Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn 
785                 790                 795                 800 


Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val 
                805                 810                 815     


Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile 
            820                 825                 830         


Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln 
        835                 840                 845             


Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly 
    850                 855                 860                 


Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
865                 870                 875                 880 


Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser 
                885                 890                 895     


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
            900                 905                 910         


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
        915                 920                 925             


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
    930                 935                 940                 


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
945                 950                 955                 960 


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
                965                 970                 975     


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
            980                 985                 990         


Lys His Glu Arg His Pro Ile Phe  Gly Asn Ile Val Asp  Glu Val Ala 
        995                 1000                 1005             


Tyr His  Glu Lys Tyr Pro Thr  Ile Tyr His Leu Arg  Lys Lys Leu 
    1010                 1015                 1020             


Val Asp  Ser Thr Asp Lys Ala  Asp Leu Arg Leu Ile  Tyr Leu Ala 
    1025                 1030                 1035             


Leu Ala  His Met Ile Lys Phe  Arg Gly His Phe Leu  Ile Glu Gly 
    1040                 1045                 1050             


Asp Leu  Asn Pro Asp Asn Ser  Asp Val Asp Lys Leu  Phe Ile Gln 
    1055                 1060                 1065             


Leu Val  Gln Thr Tyr Asn Gln  Leu Phe Glu Glu Asn  Pro Ile Asn 
    1070                 1075                 1080             


Ala Ser  Gly Val Asp Ala Lys  Ala Ile Leu Ser Ala  Arg Leu Ser 
    1085                 1090                 1095             


Lys Ser  Arg Arg Leu Glu Asn  Leu Ile Ala Gln Leu  Pro Gly Glu 
    1100                 1105                 1110             


Lys Lys  Asn Gly Leu Phe Gly  Asn Leu Ile Ala Leu  Ser Leu Gly 
    1115                 1120                 1125             


Leu Thr  Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
    1130                 1135                 1140             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1145                 1150                 1155             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1160                 1165                 1170             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1175                 1180                 1185             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1190                 1195                 1200             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1205                 1210                 1215             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1220                 1225                 1230             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1235                 1240                 1245             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1250                 1255                 1260             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1265                 1270                 1275             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1280                 1285                 1290             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1295                 1300                 1305             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1310                 1315                 1320             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1325                 1330                 1335             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1340                 1345                 1350             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1355                 1360                 1365             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1370                 1375                 1380             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1385                 1390                 1395             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1400                 1405                 1410             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1415                 1420                 1425             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1430                 1435                 1440             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Phe Asp Ser 
    1445                 1450                 1455             


Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe Asn Ala  Ser Leu Gly 
    1460                 1465                 1470             


Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys Asp Lys  Asp Phe Leu 
    1475                 1480                 1485             


Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr 
    1490                 1495                 1500             


Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys 
    1505                 1510                 1515             


Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys 
    1520                 1525                 1530             


Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile 
    1535                 1540                 1545             


Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe 
    1550                 1555                 1560             


Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile 
    1565                 1570                 1575             


His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln 
    1580                 1585                 1590             


Val Ser  Gly Gln Gly Asp Ser  Leu His Glu His Ile  Ala Asn Leu 
    1595                 1600                 1605             


Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys 
    1610                 1615                 1620             


Val Val  Asp Glu Leu Val Lys  Val Met Gly Arg His  Lys Pro Glu 
    1625                 1630                 1635             


Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys 
    1640                 1645                 1650             


Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly 
    1655                 1660                 1665             


Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys Glu His  Pro Val Glu 
    1670                 1675                 1680             


Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln 
    1685                 1690                 1695             


Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg 
    1700                 1705                 1710             


Leu Ser  Asp Tyr Asp Val Asp  His Ile Val Pro Gln  Ser Phe Leu 
    1715                 1720                 1725             


Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys 
    1730                 1735                 1740             


Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser Glu Glu  Val Val Lys 
    1745                 1750                 1755             


Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile 
    1760                 1765                 1770             


Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly 
    1775                 1780                 1785             


Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val 
    1790                 1795                 1800             


Glu Thr  Arg Gln Ile Thr Lys  His Val Ala Gln Ile  Leu Asp Ser 
    1805                 1810                 1815             


Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu 
    1820                 1825                 1830             


Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg 
    1835                 1840                 1845             


Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His 
    1850                 1855                 1860             


His Ala  His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
    1865                 1870                 1875             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1880                 1885                 1890             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1895                 1900                 1905             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1910                 1915                 1920             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1925                 1930                 1935             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1940                 1945                 1950             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1955                 1960                 1965             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1970                 1975                 1980             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1985                 1990                 1995             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    2000                 2005                 2010             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    2015                 2020                 2025             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    2030                 2035                 2040             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    2045                 2050                 2055             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    2060                 2065                 2070             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    2075                 2080                 2085             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    2090                 2095                 2100             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    2105                 2110                 2115             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    2120                 2125                 2130             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    2135                 2140                 2145             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    2150                 2155                 2160             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    2165                 2170                 2175             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    2180                 2185                 2190             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    2195                 2200                 2205             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    2210                 2215                 2220             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    2225                 2230                 2235             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Ser  Gly Gly Ser 
    2240                 2245                 2250             


Pro Lys  Lys Lys Arg Lys Val  
    2255                 2260 


<210>  62
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, hLIG3


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  nCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(2440)
<223>  hLIG3

<400>  62

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Ala Ala  Gly Thr Pro 
    1610                 1615                 1620             


Lys Lys  Lys Ala Val Val Gln  Ala Lys Leu Thr Thr  Thr Gly Gln 
    1625                 1630                 1635             


Val Thr  Ser Pro Val Lys Gly  Ala Ser Phe Val Thr  Ser Thr Asn 
    1640                 1645                 1650             


Pro Arg  Lys Phe Ser Gly Phe  Ser Ala Lys Pro Asn  Asn Ser Gly 
    1655                 1660                 1665             


Glu Ala  Pro Ser Ser Pro Thr  Pro Lys Arg Ser Leu  Ser Ser Ser 
    1670                 1675                 1680             


Lys Cys  Asp Pro Arg His Lys  Asp Cys Leu Leu Arg  Glu Phe Arg 
    1685                 1690                 1695             


Lys Leu  Cys Ala Met Val Ala  Asp Asn Pro Ser Tyr  Asn Thr Lys 
    1700                 1705                 1710             


Thr Gln  Ile Ile Gln Asp Phe  Leu Arg Lys Gly Ser  Ala Gly Asp 
    1715                 1720                 1725             


Gly Phe  His Gly Asp Val Tyr  Leu Thr Val Lys Leu  Leu Leu Pro 
    1730                 1735                 1740             


Gly Val  Ile Lys Thr Val Tyr  Asn Leu Asn Asp Lys  Gln Ile Val 
    1745                 1750                 1755             


Lys Leu  Phe Ser Arg Ile Phe  Asn Cys Asn Pro Asp  Asp Met Ala 
    1760                 1765                 1770             


Arg Asp  Leu Glu Gln Gly Asp  Val Ser Glu Thr Ile  Arg Val Phe 
    1775                 1780                 1785             


Phe Glu  Gln Ser Lys Ser Phe  Pro Pro Ala Ala Lys  Ser Leu Leu 
    1790                 1795                 1800             


Thr Ile  Gln Glu Val Asp Glu  Phe Leu Leu Arg Leu  Ser Lys Leu 
    1805                 1810                 1815             


Thr Lys  Glu Asp Glu Gln Gln  Gln Ala Leu Gln Asp  Ile Ala Ser 
    1820                 1825                 1830             


Arg Cys  Thr Ala Asn Asp Leu  Lys Cys Ile Ile Arg  Leu Ile Lys 
    1835                 1840                 1845             


His Asp  Leu Lys Met Asn Ser  Gly Ala Lys His Val  Leu Asp Ala 
    1850                 1855                 1860             


Leu Asp  Pro Asn Ala Tyr Glu  Ala Phe Lys Ala Ser  Arg Asn Leu 
    1865                 1870                 1875             


Gln Asp  Val Val Glu Arg Val  Leu His Asn Ala Gln  Glu Val Glu 
    1880                 1885                 1890             


Lys Glu  Pro Gly Gln Arg Arg  Ala Leu Ser Val Gln  Ala Ser Leu 
    1895                 1900                 1905             


Met Thr  Pro Val Gln Pro Met  Leu Ala Glu Ala Cys  Lys Ser Val 
    1910                 1915                 1920             


Glu Tyr  Ala Met Lys Lys Cys  Pro Asn Gly Met Phe  Ser Glu Ile 
    1925                 1930                 1935             


Lys Tyr  Asp Gly Glu Arg Val  Gln Val His Lys Asn  Gly Asp His 
    1940                 1945                 1950             


Phe Ser  Tyr Phe Ser Arg Ser  Leu Lys Pro Val Leu  Pro His Lys 
    1955                 1960                 1965             


Val Ala  His Phe Lys Asp Tyr  Ile Pro Gln Ala Phe  Pro Gly Gly 
    1970                 1975                 1980             


His Ser  Met Ile Leu Asp Ser  Glu Val Leu Leu Ile  Asp Asn Lys 
    1985                 1990                 1995             


Thr Gly  Lys Pro Leu Pro Phe  Gly Thr Leu Gly Val  His Lys Lys 
    2000                 2005                 2010             


Ala Ala  Phe Gln Asp Ala Asn  Val Cys Leu Phe Val  Phe Asp Cys 
    2015                 2020                 2025             


Ile Tyr  Phe Asn Asp Val Ser  Leu Met Asp Arg Pro  Leu Cys Glu 
    2030                 2035                 2040             


Arg Arg  Lys Phe Leu His Asp  Asn Met Val Glu Ile  Pro Asn Arg 
    2045                 2050                 2055             


Ile Met  Phe Ser Glu Met Lys  Arg Val Thr Lys Ala  Leu Asp Leu 
    2060                 2065                 2070             


Ala Asp  Met Ile Thr Arg Val  Ile Gln Glu Gly Leu  Glu Gly Leu 
    2075                 2080                 2085             


Val Leu  Lys Asp Val Lys Gly  Thr Tyr Glu Pro Gly  Lys Arg His 
    2090                 2095                 2100             


Trp Leu  Lys Val Lys Lys Asp  Tyr Leu Asn Glu Gly  Ala Met Ala 
    2105                 2110                 2115             


Asp Thr  Ala Asp Leu Val Val  Leu Gly Ala Phe Tyr  Gly Gln Gly 
    2120                 2125                 2130             


Ser Lys  Gly Gly Met Met Ser  Ile Phe Leu Met Gly  Cys Tyr Asp 
    2135                 2140                 2145             


Pro Gly  Ser Gln Lys Trp Cys  Thr Val Thr Lys Cys  Ala Gly Gly 
    2150                 2155                 2160             


His Asp  Asp Ala Thr Leu Ala  Arg Leu Gln Asn Glu  Leu Asp Met 
    2165                 2170                 2175             


Val Lys  Ile Ser Lys Asp Pro  Ser Lys Ile Pro Ser  Trp Leu Lys 
    2180                 2185                 2190             


Val Asn  Lys Ile Tyr Tyr Pro  Asp Phe Ile Val Pro  Asp Pro Lys 
    2195                 2200                 2205             


Lys Ala  Ala Val Trp Glu Ile  Thr Gly Ala Glu Phe  Ser Lys Ser 
    2210                 2215                 2220             


Glu Ala  His Thr Ala Asp Gly  Ile Ser Ile Arg Phe  Pro Arg Cys 
    2225                 2230                 2235             


Thr Arg  Ile Arg Asp Asp Lys  Asp Trp Lys Ser Ala  Thr Asn Leu 
    2240                 2245                 2250             


Pro Gln  Leu Lys Glu Leu Tyr  Gln Leu Ser Lys Glu  Lys Ala Asp 
    2255                 2260                 2265             


Phe Thr  Val Val Ala Gly Asp  Glu Gly Ser Ser Thr  Thr Gly Gly 
    2270                 2275                 2280             


Ser Ser  Glu Glu Asn Lys Gly  Pro Ser Gly Ser Ala  Val Ser Arg 
    2285                 2290                 2295             


Lys Ala  Pro Ser Lys Pro Ser  Ala Ser Thr Lys Lys  Ala Glu Gly 
    2300                 2305                 2310             


Lys Leu  Ser Asn Ser Asn Ser  Lys Asp Gly Asn Met  Gln Thr Ala 
    2315                 2320                 2325             


Lys Pro  Ser Ala Met Lys Val  Gly Glu Lys Leu Ala  Thr Lys Ser 
    2330                 2335                 2340             


Ser Pro  Val Lys Val Gly Glu  Lys Arg Lys Ala Ala  Asp Glu Thr 
    2345                 2350                 2355             


Leu Cys  Gln Thr Lys Val Leu  Leu Asp Ile Phe Thr  Gly Val Arg 
    2360                 2365                 2370             


Leu Tyr  Leu Pro Pro Ser Thr  Pro Asp Phe Ser Arg  Leu Arg Arg 
    2375                 2380                 2385             


Tyr Phe  Val Ala Phe Asp Gly  Asp Leu Val Gln Glu  Phe Asp Met 
    2390                 2395                 2400             


Thr Ser  Ala Thr His Val Leu  Gly Ser Arg Asp Lys  Asn Pro Ala 
    2405                 2410                 2415             


Ala Gln  Gln Val Ser Pro Glu  Trp Ile Trp Ala Cys  Ile Arg Lys 
    2420                 2425                 2430             


Arg Arg  Leu Val Ala Pro Cys  Ser Gly Gly Ser Pro  Lys Lys Lys 
    2435                 2440                 2445             


Arg Lys  Val 
    2450     


<210>  63
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, hLIG3,


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  wtCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(2440)
<223>  hLIG3

<400>  63

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Ser Lys Ala Ala  Gly Thr Pro 
    1610                 1615                 1620             


Lys Lys  Lys Ala Val Val Gln  Ala Lys Leu Thr Thr  Thr Gly Gln 
    1625                 1630                 1635             


Val Thr  Ser Pro Val Lys Gly  Ala Ser Phe Val Thr  Ser Thr Asn 
    1640                 1645                 1650             


Pro Arg  Lys Phe Ser Gly Phe  Ser Ala Lys Pro Asn  Asn Ser Gly 
    1655                 1660                 1665             


Glu Ala  Pro Ser Ser Pro Thr  Pro Lys Arg Ser Leu  Ser Ser Ser 
    1670                 1675                 1680             


Lys Cys  Asp Pro Arg His Lys  Asp Cys Leu Leu Arg  Glu Phe Arg 
    1685                 1690                 1695             


Lys Leu  Cys Ala Met Val Ala  Asp Asn Pro Ser Tyr  Asn Thr Lys 
    1700                 1705                 1710             


Thr Gln  Ile Ile Gln Asp Phe  Leu Arg Lys Gly Ser  Ala Gly Asp 
    1715                 1720                 1725             


Gly Phe  His Gly Asp Val Tyr  Leu Thr Val Lys Leu  Leu Leu Pro 
    1730                 1735                 1740             


Gly Val  Ile Lys Thr Val Tyr  Asn Leu Asn Asp Lys  Gln Ile Val 
    1745                 1750                 1755             


Lys Leu  Phe Ser Arg Ile Phe  Asn Cys Asn Pro Asp  Asp Met Ala 
    1760                 1765                 1770             


Arg Asp  Leu Glu Gln Gly Asp  Val Ser Glu Thr Ile  Arg Val Phe 
    1775                 1780                 1785             


Phe Glu  Gln Ser Lys Ser Phe  Pro Pro Ala Ala Lys  Ser Leu Leu 
    1790                 1795                 1800             


Thr Ile  Gln Glu Val Asp Glu  Phe Leu Leu Arg Leu  Ser Lys Leu 
    1805                 1810                 1815             


Thr Lys  Glu Asp Glu Gln Gln  Gln Ala Leu Gln Asp  Ile Ala Ser 
    1820                 1825                 1830             


Arg Cys  Thr Ala Asn Asp Leu  Lys Cys Ile Ile Arg  Leu Ile Lys 
    1835                 1840                 1845             


His Asp  Leu Lys Met Asn Ser  Gly Ala Lys His Val  Leu Asp Ala 
    1850                 1855                 1860             


Leu Asp  Pro Asn Ala Tyr Glu  Ala Phe Lys Ala Ser  Arg Asn Leu 
    1865                 1870                 1875             


Gln Asp  Val Val Glu Arg Val  Leu His Asn Ala Gln  Glu Val Glu 
    1880                 1885                 1890             


Lys Glu  Pro Gly Gln Arg Arg  Ala Leu Ser Val Gln  Ala Ser Leu 
    1895                 1900                 1905             


Met Thr  Pro Val Gln Pro Met  Leu Ala Glu Ala Cys  Lys Ser Val 
    1910                 1915                 1920             


Glu Tyr  Ala Met Lys Lys Cys  Pro Asn Gly Met Phe  Ser Glu Ile 
    1925                 1930                 1935             


Lys Tyr  Asp Gly Glu Arg Val  Gln Val His Lys Asn  Gly Asp His 
    1940                 1945                 1950             


Phe Ser  Tyr Phe Ser Arg Ser  Leu Lys Pro Val Leu  Pro His Lys 
    1955                 1960                 1965             


Val Ala  His Phe Lys Asp Tyr  Ile Pro Gln Ala Phe  Pro Gly Gly 
    1970                 1975                 1980             


His Ser  Met Ile Leu Asp Ser  Glu Val Leu Leu Ile  Asp Asn Lys 
    1985                 1990                 1995             


Thr Gly  Lys Pro Leu Pro Phe  Gly Thr Leu Gly Val  His Lys Lys 
    2000                 2005                 2010             


Ala Ala  Phe Gln Asp Ala Asn  Val Cys Leu Phe Val  Phe Asp Cys 
    2015                 2020                 2025             


Ile Tyr  Phe Asn Asp Val Ser  Leu Met Asp Arg Pro  Leu Cys Glu 
    2030                 2035                 2040             


Arg Arg  Lys Phe Leu His Asp  Asn Met Val Glu Ile  Pro Asn Arg 
    2045                 2050                 2055             


Ile Met  Phe Ser Glu Met Lys  Arg Val Thr Lys Ala  Leu Asp Leu 
    2060                 2065                 2070             


Ala Asp  Met Ile Thr Arg Val  Ile Gln Glu Gly Leu  Glu Gly Leu 
    2075                 2080                 2085             


Val Leu  Lys Asp Val Lys Gly  Thr Tyr Glu Pro Gly  Lys Arg His 
    2090                 2095                 2100             


Trp Leu  Lys Val Lys Lys Asp  Tyr Leu Asn Glu Gly  Ala Met Ala 
    2105                 2110                 2115             


Asp Thr  Ala Asp Leu Val Val  Leu Gly Ala Phe Tyr  Gly Gln Gly 
    2120                 2125                 2130             


Ser Lys  Gly Gly Met Met Ser  Ile Phe Leu Met Gly  Cys Tyr Asp 
    2135                 2140                 2145             


Pro Gly  Ser Gln Lys Trp Cys  Thr Val Thr Lys Cys  Ala Gly Gly 
    2150                 2155                 2160             


His Asp  Asp Ala Thr Leu Ala  Arg Leu Gln Asn Glu  Leu Asp Met 
    2165                 2170                 2175             


Val Lys  Ile Ser Lys Asp Pro  Ser Lys Ile Pro Ser  Trp Leu Lys 
    2180                 2185                 2190             


Val Asn  Lys Ile Tyr Tyr Pro  Asp Phe Ile Val Pro  Asp Pro Lys 
    2195                 2200                 2205             


Lys Ala  Ala Val Trp Glu Ile  Thr Gly Ala Glu Phe  Ser Lys Ser 
    2210                 2215                 2220             


Glu Ala  His Thr Ala Asp Gly  Ile Ser Ile Arg Phe  Pro Arg Cys 
    2225                 2230                 2235             


Thr Arg  Ile Arg Asp Asp Lys  Asp Trp Lys Ser Ala  Thr Asn Leu 
    2240                 2245                 2250             


Pro Gln  Leu Lys Glu Leu Tyr  Gln Leu Ser Lys Glu  Lys Ala Asp 
    2255                 2260                 2265             


Phe Thr  Val Val Ala Gly Asp  Glu Gly Ser Ser Thr  Thr Gly Gly 
    2270                 2275                 2280             


Ser Ser  Glu Glu Asn Lys Gly  Pro Ser Gly Ser Ala  Val Ser Arg 
    2285                 2290                 2295             


Lys Ala  Pro Ser Lys Pro Ser  Ala Ser Thr Lys Lys  Ala Glu Gly 
    2300                 2305                 2310             


Lys Leu  Ser Asn Ser Asn Ser  Lys Asp Gly Asn Met  Gln Thr Ala 
    2315                 2320                 2325             


Lys Pro  Ser Ala Met Lys Val  Gly Glu Lys Leu Ala  Thr Lys Ser 
    2330                 2335                 2340             


Ser Pro  Val Lys Val Gly Glu  Lys Arg Lys Ala Ala  Asp Glu Thr 
    2345                 2350                 2355             


Leu Cys  Gln Thr Lys Val Leu  Leu Asp Ile Phe Thr  Gly Val Arg 
    2360                 2365                 2370             


Leu Tyr  Leu Pro Pro Ser Thr  Pro Asp Phe Ser Arg  Leu Arg Arg 
    2375                 2380                 2385             


Tyr Phe  Val Ala Phe Asp Gly  Asp Leu Val Gln Glu  Phe Asp Met 
    2390                 2395                 2400             


Thr Ser  Ala Thr His Val Leu  Gly Ser Arg Asp Lys  Asn Pro Ala 
    2405                 2410                 2415             


Ala Gln  Gln Val Ser Pro Glu  Trp Ile Trp Ala Cys  Ile Arg Lys 
    2420                 2425                 2430             


Arg Arg  Leu Val Ala Pro Cys  Ser Gly Gly Ser Pro  Lys Lys Lys 
    2435                 2440                 2445             


Arg Lys  Val 
    2450     


<210>  64
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXC, hLIG3


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (234)..(1057)
<223>  hLIG3

<220>
<221>  MISC_FEATURE
<222>  (1074)..(2440)
<223>  nCas9

<400>  64

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Ser Lys Ala Ala Gly Thr Pro 
225                 230                 235                 240 


Lys Lys Lys Ala Val Val Gln Ala Lys Leu Thr Thr Thr Gly Gln Val 
                245                 250                 255     


Thr Ser Pro Val Lys Gly Ala Ser Phe Val Thr Ser Thr Asn Pro Arg 
            260                 265                 270         


Lys Phe Ser Gly Phe Ser Ala Lys Pro Asn Asn Ser Gly Glu Ala Pro 
        275                 280                 285             


Ser Ser Pro Thr Pro Lys Arg Ser Leu Ser Ser Ser Lys Cys Asp Pro 
    290                 295                 300                 


Arg His Lys Asp Cys Leu Leu Arg Glu Phe Arg Lys Leu Cys Ala Met 
305                 310                 315                 320 


Val Ala Asp Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile Gln Asp 
                325                 330                 335     


Phe Leu Arg Lys Gly Ser Ala Gly Asp Gly Phe His Gly Asp Val Tyr 
            340                 345                 350         


Leu Thr Val Lys Leu Leu Leu Pro Gly Val Ile Lys Thr Val Tyr Asn 
        355                 360                 365             


Leu Asn Asp Lys Gln Ile Val Lys Leu Phe Ser Arg Ile Phe Asn Cys 
    370                 375                 380                 


Asn Pro Asp Asp Met Ala Arg Asp Leu Glu Gln Gly Asp Val Ser Glu 
385                 390                 395                 400 


Thr Ile Arg Val Phe Phe Glu Gln Ser Lys Ser Phe Pro Pro Ala Ala 
                405                 410                 415     


Lys Ser Leu Leu Thr Ile Gln Glu Val Asp Glu Phe Leu Leu Arg Leu 
            420                 425                 430         


Ser Lys Leu Thr Lys Glu Asp Glu Gln Gln Gln Ala Leu Gln Asp Ile 
        435                 440                 445             


Ala Ser Arg Cys Thr Ala Asn Asp Leu Lys Cys Ile Ile Arg Leu Ile 
    450                 455                 460                 


Lys His Asp Leu Lys Met Asn Ser Gly Ala Lys His Val Leu Asp Ala 
465                 470                 475                 480 


Leu Asp Pro Asn Ala Tyr Glu Ala Phe Lys Ala Ser Arg Asn Leu Gln 
                485                 490                 495     


Asp Val Val Glu Arg Val Leu His Asn Ala Gln Glu Val Glu Lys Glu 
            500                 505                 510         


Pro Gly Gln Arg Arg Ala Leu Ser Val Gln Ala Ser Leu Met Thr Pro 
        515                 520                 525             


Val Gln Pro Met Leu Ala Glu Ala Cys Lys Ser Val Glu Tyr Ala Met 
    530                 535                 540                 


Lys Lys Cys Pro Asn Gly Met Phe Ser Glu Ile Lys Tyr Asp Gly Glu 
545                 550                 555                 560 


Arg Val Gln Val His Lys Asn Gly Asp His Phe Ser Tyr Phe Ser Arg 
                565                 570                 575     


Ser Leu Lys Pro Val Leu Pro His Lys Val Ala His Phe Lys Asp Tyr 
            580                 585                 590         


Ile Pro Gln Ala Phe Pro Gly Gly His Ser Met Ile Leu Asp Ser Glu 
        595                 600                 605             


Val Leu Leu Ile Asp Asn Lys Thr Gly Lys Pro Leu Pro Phe Gly Thr 
    610                 615                 620                 


Leu Gly Val His Lys Lys Ala Ala Phe Gln Asp Ala Asn Val Cys Leu 
625                 630                 635                 640 


Phe Val Phe Asp Cys Ile Tyr Phe Asn Asp Val Ser Leu Met Asp Arg 
                645                 650                 655     


Pro Leu Cys Glu Arg Arg Lys Phe Leu His Asp Asn Met Val Glu Ile 
            660                 665                 670         


Pro Asn Arg Ile Met Phe Ser Glu Met Lys Arg Val Thr Lys Ala Leu 
        675                 680                 685             


Asp Leu Ala Asp Met Ile Thr Arg Val Ile Gln Glu Gly Leu Glu Gly 
    690                 695                 700                 


Leu Val Leu Lys Asp Val Lys Gly Thr Tyr Glu Pro Gly Lys Arg His 
705                 710                 715                 720 


Trp Leu Lys Val Lys Lys Asp Tyr Leu Asn Glu Gly Ala Met Ala Asp 
                725                 730                 735     


Thr Ala Asp Leu Val Val Leu Gly Ala Phe Tyr Gly Gln Gly Ser Lys 
            740                 745                 750         


Gly Gly Met Met Ser Ile Phe Leu Met Gly Cys Tyr Asp Pro Gly Ser 
        755                 760                 765             


Gln Lys Trp Cys Thr Val Thr Lys Cys Ala Gly Gly His Asp Asp Ala 
    770                 775                 780                 


Thr Leu Ala Arg Leu Gln Asn Glu Leu Asp Met Val Lys Ile Ser Lys 
785                 790                 795                 800 


Asp Pro Ser Lys Ile Pro Ser Trp Leu Lys Val Asn Lys Ile Tyr Tyr 
                805                 810                 815     


Pro Asp Phe Ile Val Pro Asp Pro Lys Lys Ala Ala Val Trp Glu Ile 
            820                 825                 830         


Thr Gly Ala Glu Phe Ser Lys Ser Glu Ala His Thr Ala Asp Gly Ile 
        835                 840                 845             


Ser Ile Arg Phe Pro Arg Cys Thr Arg Ile Arg Asp Asp Lys Asp Trp 
    850                 855                 860                 


Lys Ser Ala Thr Asn Leu Pro Gln Leu Lys Glu Leu Tyr Gln Leu Ser 
865                 870                 875                 880 


Lys Glu Lys Ala Asp Phe Thr Val Val Ala Gly Asp Glu Gly Ser Ser 
                885                 890                 895     


Thr Thr Gly Gly Ser Ser Glu Glu Asn Lys Gly Pro Ser Gly Ser Ala 
            900                 905                 910         


Val Ser Arg Lys Ala Pro Ser Lys Pro Ser Ala Ser Thr Lys Lys Ala 
        915                 920                 925             


Glu Gly Lys Leu Ser Asn Ser Asn Ser Lys Asp Gly Asn Met Gln Thr 
    930                 935                 940                 


Ala Lys Pro Ser Ala Met Lys Val Gly Glu Lys Leu Ala Thr Lys Ser 
945                 950                 955                 960 


Ser Pro Val Lys Val Gly Glu Lys Arg Lys Ala Ala Asp Glu Thr Leu 
                965                 970                 975     


Cys Gln Thr Lys Val Leu Leu Asp Ile Phe Thr Gly Val Arg Leu Tyr 
            980                 985                 990         


Leu Pro Pro Ser Thr Pro Asp Phe  Ser Arg Leu Arg Arg  Tyr Phe Val 
        995                 1000                 1005             


Ala Phe  Asp Gly Asp Leu Val  Gln Glu Phe Asp Met  Thr Ser Ala 
    1010                 1015                 1020             


Thr His  Val Leu Gly Ser Arg  Asp Lys Asn Pro Ala  Ala Gln Gln 
    1025                 1030                 1035             


Val Ser  Pro Glu Trp Ile Trp  Ala Cys Ile Arg Lys  Arg Arg Leu 
    1040                 1045                 1050             


Val Ala  Pro Cys Ser Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser 
    1055                 1060                 1065             


Ala Thr  Pro Glu Ser Asp Lys  Lys Tyr Ser Ile Gly  Leu Ala Ile 
    1070                 1075                 1080             


Gly Thr  Asn Ser Val Gly Trp  Ala Val Ile Thr Asp  Glu Tyr Lys 
    1085                 1090                 1095             


Val Pro  Ser Lys Lys Phe Lys  Val Leu Gly Asn Thr  Asp Arg His 
    1100                 1105                 1110             


Ser Ile  Lys Lys Asn Leu Ile  Gly Ala Leu Leu Phe  Asp Ser Gly 
    1115                 1120                 1125             


Glu Thr  Ala Glu Ala Thr Arg  Leu Lys Arg Thr Ala  Arg Arg Arg 
    1130                 1135                 1140             


Tyr Thr  Arg Arg Lys Asn Arg  Ile Cys Tyr Leu Gln  Glu Ile Phe 
    1145                 1150                 1155             


Ser Asn  Glu Met Ala Lys Val  Asp Asp Ser Phe Phe  His Arg Leu 
    1160                 1165                 1170             


Glu Glu  Ser Phe Leu Val Glu  Glu Asp Lys Lys His  Glu Arg His 
    1175                 1180                 1185             


Pro Ile  Phe Gly Asn Ile Val  Asp Glu Val Ala Tyr  His Glu Lys 
    1190                 1195                 1200             


Tyr Pro  Thr Ile Tyr His Leu  Arg Lys Lys Leu Val  Asp Ser Thr 
    1205                 1210                 1215             


Asp Lys  Ala Asp Leu Arg Leu  Ile Tyr Leu Ala Leu  Ala His Met 
    1220                 1225                 1230             


Ile Lys  Phe Arg Gly His Phe  Leu Ile Glu Gly Asp  Leu Asn Pro 
    1235                 1240                 1245             


Asp Asn  Ser Asp Val Asp Lys  Leu Phe Ile Gln Leu  Val Gln Thr 
    1250                 1255                 1260             


Tyr Asn  Gln Leu Phe Glu Glu  Asn Pro Ile Asn Ala  Ser Gly Val 
    1265                 1270                 1275             


Asp Ala  Lys Ala Ile Leu Ser  Ala Arg Leu Ser Lys  Ser Arg Arg 
    1280                 1285                 1290             


Leu Glu  Asn Leu Ile Ala Gln  Leu Pro Gly Glu Lys  Lys Asn Gly 
    1295                 1300                 1305             


Leu Phe  Gly Asn Leu Ile Ala  Leu Ser Leu Gly Leu  Thr Pro Asn 
    1310                 1315                 1320             


Phe Lys  Ser Asn Phe Asp Leu  Ala Glu Asp Ala Lys  Leu Gln Leu 
    1325                 1330                 1335             


Ser Lys  Asp Thr Tyr Asp Asp  Asp Leu Asp Asn Leu  Leu Ala Gln 
    1340                 1345                 1350             


Ile Gly  Asp Gln Tyr Ala Asp  Leu Phe Leu Ala Ala  Lys Asn Leu 
    1355                 1360                 1365             


Ser Asp  Ala Ile Leu Leu Ser  Asp Ile Leu Arg Val  Asn Thr Glu 
    1370                 1375                 1380             


Ile Thr  Lys Ala Pro Leu Ser  Ala Ser Met Ile Lys  Arg Tyr Asp 
    1385                 1390                 1395             


Glu His  His Gln Asp Leu Thr  Leu Leu Lys Ala Leu  Val Arg Gln 
    1400                 1405                 1410             


Gln Leu  Pro Glu Lys Tyr Lys  Glu Ile Phe Phe Asp  Gln Ser Lys 
    1415                 1420                 1425             


Asn Gly  Tyr Ala Gly Tyr Ile  Asp Gly Gly Ala Ser  Gln Glu Glu 
    1430                 1435                 1440             


Phe Tyr  Lys Phe Ile Lys Pro  Ile Leu Glu Lys Met  Asp Gly Thr 
    1445                 1450                 1455             


Glu Glu  Leu Leu Val Lys Leu  Asn Arg Glu Asp Leu  Leu Arg Lys 
    1460                 1465                 1470             


Gln Arg  Thr Phe Asp Asn Gly  Ser Ile Pro His Gln  Ile His Leu 
    1475                 1480                 1485             


Gly Glu  Leu His Ala Ile Leu  Arg Arg Gln Glu Asp  Phe Tyr Pro 
    1490                 1495                 1500             


Phe Leu  Lys Asp Asn Arg Glu  Lys Ile Glu Lys Ile  Leu Thr Phe 
    1505                 1510                 1515             


Arg Ile  Pro Tyr Tyr Val Gly  Pro Leu Ala Arg Gly  Asn Ser Arg 
    1520                 1525                 1530             


Phe Ala  Trp Met Thr Arg Lys  Ser Glu Glu Thr Ile  Thr Pro Trp 
    1535                 1540                 1545             


Asn Phe  Glu Glu Val Val Asp  Lys Gly Ala Ser Ala  Gln Ser Phe 
    1550                 1555                 1560             


Ile Glu  Arg Met Thr Asn Phe  Asp Lys Asn Leu Pro  Asn Glu Lys 
    1565                 1570                 1575             


Val Leu  Pro Lys His Ser Leu  Leu Tyr Glu Tyr Phe  Thr Val Tyr 
    1580                 1585                 1590             


Asn Glu  Leu Thr Lys Val Lys  Tyr Val Thr Glu Gly  Met Arg Lys 
    1595                 1600                 1605             


Pro Ala  Phe Leu Ser Gly Glu  Gln Lys Lys Ala Ile  Val Asp Leu 
    1610                 1615                 1620             


Leu Phe  Lys Thr Asn Arg Lys  Val Thr Val Lys Gln  Leu Lys Glu 
    1625                 1630                 1635             


Asp Tyr  Phe Lys Lys Ile Glu  Cys Phe Asp Ser Val  Glu Ile Ser 
    1640                 1645                 1650             


Gly Val  Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
    1655                 1660                 1665             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1670                 1675                 1680             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1685                 1690                 1695             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1700                 1705                 1710             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1715                 1720                 1725             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1730                 1735                 1740             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1745                 1750                 1755             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1760                 1765                 1770             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1775                 1780                 1785             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1790                 1795                 1800             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1805                 1810                 1815             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1820                 1825                 1830             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1835                 1840                 1845             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1850                 1855                 1860             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1865                 1870                 1875             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1880                 1885                 1890             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1895                 1900                 1905             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1910                 1915                 1920             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1925                 1930                 1935             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1940                 1945                 1950             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1955                 1960                 1965             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1970                 1975                 1980             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1985                 1990                 1995             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    2000                 2005                 2010             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    2015                 2020                 2025             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    2030                 2035                 2040             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    2045                 2050                 2055             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    2060                 2065                 2070             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    2075                 2080                 2085             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    2090                 2095                 2100             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    2105                 2110                 2115             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    2120                 2125                 2130             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    2135                 2140                 2145             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    2150                 2155                 2160             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    2165                 2170                 2175             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    2180                 2185                 2190             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    2195                 2200                 2205             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    2210                 2215                 2220             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    2225                 2230                 2235             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    2240                 2245                 2250             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    2255                 2260                 2265             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    2270                 2275                 2280             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    2285                 2290                 2295             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    2300                 2305                 2310             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    2315                 2320                 2325             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    2330                 2335                 2340             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    2345                 2350                 2355             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    2360                 2365                 2370             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    2375                 2380                 2385             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    2390                 2395                 2400             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    2405                 2410                 2415             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    2420                 2425                 2430             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys 
    2435                 2440                 2445             


Arg Lys  Val 
    2450     


<210>  65
<211>  2451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAC, hLIG3


<220>
<221>  MISC_FEATURE
<222>  (1)..(825)
<223>  hLIG3

<220>
<221>  MISC_FEATURE
<222>  (830)..(1057)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (1074)..(2440)
<223>  nCas9

<400>  65

Met Ser Lys Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln Ala 
1               5                   10                  15      


Lys Leu Thr Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala Ser 
            20                  25                  30          


Phe Val Thr Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala Lys 
        35                  40                  45              


Pro Asn Asn Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg Ser 
    50                  55                  60                  


Leu Ser Ser Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu Arg 
65                  70                  75                  80  


Glu Phe Arg Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr Asn 
                85                  90                  95      


Thr Lys Thr Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala Gly 
            100                 105                 110         


Asp Gly Phe His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu Pro 
        115                 120                 125             


Gly Val Ile Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val Lys 
    130                 135                 140                 


Leu Phe Ser Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg Asp 
145                 150                 155                 160 


Leu Glu Gln Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu Gln 
                165                 170                 175     


Ser Lys Ser Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln Glu 
            180                 185                 190         


Val Asp Glu Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp Glu 
        195                 200                 205             


Gln Gln Gln Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn Asp 
    210                 215                 220                 


Leu Lys Cys Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn Ser 
225                 230                 235                 240 


Gly Ala Lys His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu Ala 
                245                 250                 255     


Phe Lys Ala Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu His 
            260                 265                 270         


Asn Ala Gln Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu Ser 
        275                 280                 285             


Val Gln Ala Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu Ala 
    290                 295                 300                 


Cys Lys Ser Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met Phe 
305                 310                 315                 320 


Ser Glu Ile Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn Gly 
                325                 330                 335     


Asp His Phe Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro His 
            340                 345                 350         


Lys Val Ala His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly Gly 
        355                 360                 365             


His Ser Met Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys Thr 
    370                 375                 380                 


Gly Lys Pro Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala Ala 
385                 390                 395                 400 


Phe Gln Asp Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr Phe 
                405                 410                 415     


Asn Asp Val Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys Phe 
            420                 425                 430         


Leu His Asp Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser Glu 
        435                 440                 445             


Met Lys Arg Val Thr Lys Ala Leu Asp Leu Ala Asp Met Ile Thr Arg 
    450                 455                 460                 


Val Ile Gln Glu Gly Leu Glu Gly Leu Val Leu Lys Asp Val Lys Gly 
465                 470                 475                 480 


Thr Tyr Glu Pro Gly Lys Arg His Trp Leu Lys Val Lys Lys Asp Tyr 
                485                 490                 495     


Leu Asn Glu Gly Ala Met Ala Asp Thr Ala Asp Leu Val Val Leu Gly 
            500                 505                 510         


Ala Phe Tyr Gly Gln Gly Ser Lys Gly Gly Met Met Ser Ile Phe Leu 
        515                 520                 525             


Met Gly Cys Tyr Asp Pro Gly Ser Gln Lys Trp Cys Thr Val Thr Lys 
    530                 535                 540                 


Cys Ala Gly Gly His Asp Asp Ala Thr Leu Ala Arg Leu Gln Asn Glu 
545                 550                 555                 560 


Leu Asp Met Val Lys Ile Ser Lys Asp Pro Ser Lys Ile Pro Ser Trp 
                565                 570                 575     


Leu Lys Val Asn Lys Ile Tyr Tyr Pro Asp Phe Ile Val Pro Asp Pro 
            580                 585                 590         


Lys Lys Ala Ala Val Trp Glu Ile Thr Gly Ala Glu Phe Ser Lys Ser 
        595                 600                 605             


Glu Ala His Thr Ala Asp Gly Ile Ser Ile Arg Phe Pro Arg Cys Thr 
    610                 615                 620                 


Arg Ile Arg Asp Asp Lys Asp Trp Lys Ser Ala Thr Asn Leu Pro Gln 
625                 630                 635                 640 


Leu Lys Glu Leu Tyr Gln Leu Ser Lys Glu Lys Ala Asp Phe Thr Val 
                645                 650                 655     


Val Ala Gly Asp Glu Gly Ser Ser Thr Thr Gly Gly Ser Ser Glu Glu 
            660                 665                 670         


Asn Lys Gly Pro Ser Gly Ser Ala Val Ser Arg Lys Ala Pro Ser Lys 
        675                 680                 685             


Pro Ser Ala Ser Thr Lys Lys Ala Glu Gly Lys Leu Ser Asn Ser Asn 
    690                 695                 700                 


Ser Lys Asp Gly Asn Met Gln Thr Ala Lys Pro Ser Ala Met Lys Val 
705                 710                 715                 720 


Gly Glu Lys Leu Ala Thr Lys Ser Ser Pro Val Lys Val Gly Glu Lys 
                725                 730                 735     


Arg Lys Ala Ala Asp Glu Thr Leu Cys Gln Thr Lys Val Leu Leu Asp 
            740                 745                 750         


Ile Phe Thr Gly Val Arg Leu Tyr Leu Pro Pro Ser Thr Pro Asp Phe 
        755                 760                 765             


Ser Arg Leu Arg Arg Tyr Phe Val Ala Phe Asp Gly Asp Leu Val Gln 
    770                 775                 780                 


Glu Phe Asp Met Thr Ser Ala Thr His Val Leu Gly Ser Arg Asp Lys 
785                 790                 795                 800 


Asn Pro Ala Ala Gln Gln Val Ser Pro Glu Trp Ile Trp Ala Cys Ile 
                805                 810                 815     


Arg Lys Arg Arg Leu Val Ala Pro Cys Ser Gly Gly Ser Ser Ser Glu 
            820                 825                 830         


Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro 
        835                 840                 845             


His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr 
    850                 855                 860                 


Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg 
865                 870                 875                 880 


His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu 
                885                 890                 895     


Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile 
            900                 905                 910         


Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile 
        915                 920                 925             


Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile 
    930                 935                 940                 


Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg 
945                 950                 955                 960 


Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu 
                965                 970                 975     


Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu 
            980                 985                 990         


Ala His Trp Pro Arg Tyr Pro His  Leu Trp Val Arg Leu  Tyr Val Leu 
        995                 1000                 1005             


Glu Leu  Tyr Cys Ile Ile Leu  Gly Leu Pro Pro Cys  Leu Asn Ile 
    1010                 1015                 1020             


Leu Arg  Arg Lys Gln Pro Gln  Leu Thr Phe Phe Thr  Ile Ala Leu 
    1025                 1030                 1035             


Gln Ser  Cys His Tyr Gln Arg  Leu Pro Pro His Ile  Leu Trp Ala 
    1040                 1045                 1050             


Thr Gly  Leu Lys Ser Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser 
    1055                 1060                 1065             


Ala Thr  Pro Glu Ser Asp Lys  Lys Tyr Ser Ile Gly  Leu Ala Ile 
    1070                 1075                 1080             


Gly Thr  Asn Ser Val Gly Trp  Ala Val Ile Thr Asp  Glu Tyr Lys 
    1085                 1090                 1095             


Val Pro  Ser Lys Lys Phe Lys  Val Leu Gly Asn Thr  Asp Arg His 
    1100                 1105                 1110             


Ser Ile  Lys Lys Asn Leu Ile  Gly Ala Leu Leu Phe  Asp Ser Gly 
    1115                 1120                 1125             


Glu Thr  Ala Glu Ala Thr Arg  Leu Lys Arg Thr Ala  Arg Arg Arg 
    1130                 1135                 1140             


Tyr Thr  Arg Arg Lys Asn Arg  Ile Cys Tyr Leu Gln  Glu Ile Phe 
    1145                 1150                 1155             


Ser Asn  Glu Met Ala Lys Val  Asp Asp Ser Phe Phe  His Arg Leu 
    1160                 1165                 1170             


Glu Glu  Ser Phe Leu Val Glu  Glu Asp Lys Lys His  Glu Arg His 
    1175                 1180                 1185             


Pro Ile  Phe Gly Asn Ile Val  Asp Glu Val Ala Tyr  His Glu Lys 
    1190                 1195                 1200             


Tyr Pro  Thr Ile Tyr His Leu  Arg Lys Lys Leu Val  Asp Ser Thr 
    1205                 1210                 1215             


Asp Lys  Ala Asp Leu Arg Leu  Ile Tyr Leu Ala Leu  Ala His Met 
    1220                 1225                 1230             


Ile Lys  Phe Arg Gly His Phe  Leu Ile Glu Gly Asp  Leu Asn Pro 
    1235                 1240                 1245             


Asp Asn  Ser Asp Val Asp Lys  Leu Phe Ile Gln Leu  Val Gln Thr 
    1250                 1255                 1260             


Tyr Asn  Gln Leu Phe Glu Glu  Asn Pro Ile Asn Ala  Ser Gly Val 
    1265                 1270                 1275             


Asp Ala  Lys Ala Ile Leu Ser  Ala Arg Leu Ser Lys  Ser Arg Arg 
    1280                 1285                 1290             


Leu Glu  Asn Leu Ile Ala Gln  Leu Pro Gly Glu Lys  Lys Asn Gly 
    1295                 1300                 1305             


Leu Phe  Gly Asn Leu Ile Ala  Leu Ser Leu Gly Leu  Thr Pro Asn 
    1310                 1315                 1320             


Phe Lys  Ser Asn Phe Asp Leu  Ala Glu Asp Ala Lys  Leu Gln Leu 
    1325                 1330                 1335             


Ser Lys  Asp Thr Tyr Asp Asp  Asp Leu Asp Asn Leu  Leu Ala Gln 
    1340                 1345                 1350             


Ile Gly  Asp Gln Tyr Ala Asp  Leu Phe Leu Ala Ala  Lys Asn Leu 
    1355                 1360                 1365             


Ser Asp  Ala Ile Leu Leu Ser  Asp Ile Leu Arg Val  Asn Thr Glu 
    1370                 1375                 1380             


Ile Thr  Lys Ala Pro Leu Ser  Ala Ser Met Ile Lys  Arg Tyr Asp 
    1385                 1390                 1395             


Glu His  His Gln Asp Leu Thr  Leu Leu Lys Ala Leu  Val Arg Gln 
    1400                 1405                 1410             


Gln Leu  Pro Glu Lys Tyr Lys  Glu Ile Phe Phe Asp  Gln Ser Lys 
    1415                 1420                 1425             


Asn Gly  Tyr Ala Gly Tyr Ile  Asp Gly Gly Ala Ser  Gln Glu Glu 
    1430                 1435                 1440             


Phe Tyr  Lys Phe Ile Lys Pro  Ile Leu Glu Lys Met  Asp Gly Thr 
    1445                 1450                 1455             


Glu Glu  Leu Leu Val Lys Leu  Asn Arg Glu Asp Leu  Leu Arg Lys 
    1460                 1465                 1470             


Gln Arg  Thr Phe Asp Asn Gly  Ser Ile Pro His Gln  Ile His Leu 
    1475                 1480                 1485             


Gly Glu  Leu His Ala Ile Leu  Arg Arg Gln Glu Asp  Phe Tyr Pro 
    1490                 1495                 1500             


Phe Leu  Lys Asp Asn Arg Glu  Lys Ile Glu Lys Ile  Leu Thr Phe 
    1505                 1510                 1515             


Arg Ile  Pro Tyr Tyr Val Gly  Pro Leu Ala Arg Gly  Asn Ser Arg 
    1520                 1525                 1530             


Phe Ala  Trp Met Thr Arg Lys  Ser Glu Glu Thr Ile  Thr Pro Trp 
    1535                 1540                 1545             


Asn Phe  Glu Glu Val Val Asp  Lys Gly Ala Ser Ala  Gln Ser Phe 
    1550                 1555                 1560             


Ile Glu  Arg Met Thr Asn Phe  Asp Lys Asn Leu Pro  Asn Glu Lys 
    1565                 1570                 1575             


Val Leu  Pro Lys His Ser Leu  Leu Tyr Glu Tyr Phe  Thr Val Tyr 
    1580                 1585                 1590             


Asn Glu  Leu Thr Lys Val Lys  Tyr Val Thr Glu Gly  Met Arg Lys 
    1595                 1600                 1605             


Pro Ala  Phe Leu Ser Gly Glu  Gln Lys Lys Ala Ile  Val Asp Leu 
    1610                 1615                 1620             


Leu Phe  Lys Thr Asn Arg Lys  Val Thr Val Lys Gln  Leu Lys Glu 
    1625                 1630                 1635             


Asp Tyr  Phe Lys Lys Ile Glu  Cys Phe Asp Ser Val  Glu Ile Ser 
    1640                 1645                 1650             


Gly Val  Glu Asp Arg Phe Asn  Ala Ser Leu Gly Thr  Tyr His Asp 
    1655                 1660                 1665             


Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe Leu Asp  Asn Glu Glu 
    1670                 1675                 1680             


Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu Thr Leu  Thr Leu Phe 
    1685                 1690                 1695             


Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu Lys Thr  Tyr Ala His 
    1700                 1705                 1710             


Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu Lys Arg  Arg Arg Tyr 
    1715                 1720                 1725             


Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu Ile Asn  Gly Ile Arg 
    1730                 1735                 1740             


Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp Phe Leu  Lys Ser Asp 
    1745                 1750                 1755             


Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu Ile His  Asp Asp Ser 
    1760                 1765                 1770             


Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala Gln Val  Ser Gly Gln 
    1775                 1780                 1785             


Gly Asp  Ser Leu His Glu His  Ile Ala Asn Leu Ala  Gly Ser Pro 
    1790                 1795                 1800             


Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val Lys Val  Val Asp Glu 
    1805                 1810                 1815             


Leu Val  Lys Val Met Gly Arg  His Lys Pro Glu Asn  Ile Val Ile 
    1820                 1825                 1830             


Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln Lys Gly  Gln Lys Asn 
    1835                 1840                 1845             


Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu Gly Ile  Lys Glu Leu 
    1850                 1855                 1860             


Gly Ser  Gln Ile Leu Lys Glu  His Pro Val Glu Asn  Thr Gln Leu 
    1865                 1870                 1875             


Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp 
    1880                 1885                 1890             


Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr 
    1895                 1900                 1905             


Asp Val  Asp His Ile Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser 
    1910                 1915                 1920             


Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys 
    1925                 1930                 1935             


Ser Asp  Asn Val Pro Ser Glu  Glu Val Val Lys Lys  Met Lys Asn 
    1940                 1945                 1950             


Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys 
    1955                 1960                 1965             


Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu 
    1970                 1975                 1980             


Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln 
    1985                 1990                 1995             


Ile Thr  Lys His Val Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr 
    2000                 2005                 2010             


Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile 
    2015                 2020                 2025             


Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln 
    2030                 2035                 2040             


Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr His His  Ala His Asp 
    2045                 2050                 2055             


Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
    2060                 2065                 2070             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    2075                 2080                 2085             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    2090                 2095                 2100             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    2105                 2110                 2115             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    2120                 2125                 2130             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    2135                 2140                 2145             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    2150                 2155                 2160             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    2165                 2170                 2175             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    2180                 2185                 2190             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    2195                 2200                 2205             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    2210                 2215                 2220             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    2225                 2230                 2235             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    2240                 2245                 2250             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    2255                 2260                 2265             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    2270                 2275                 2280             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    2285                 2290                 2295             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    2300                 2305                 2310             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    2315                 2320                 2325             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    2330                 2335                 2340             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    2345                 2350                 2355             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    2360                 2365                 2370             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    2375                 2380                 2385             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    2390                 2395                 2400             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    2405                 2410                 2415             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    2420                 2425                 2430             


Leu Ser  Gln Leu Gly Gly Asp  Ser Gly Gly Ser Pro  Lys Lys Lys 
    2435                 2440                 2445             


Arg Lys  Val 
    2450     


<210>  66
<211>  2569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, rLIG3


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  nCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(2558)
<223>  rLIG3

<400>  66

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Leu Ala Phe  Lys Thr Leu 
    1610                 1615                 1620             


Phe Pro  Arg Asn Leu Cys Ala  Leu Gly Arg Lys Glu  Leu Cys Leu 
    1625                 1630                 1635             


Phe Ser  Glu Gln His His Trp  Pro Ala Ile Arg Gln  Phe Ser Gln 
    1640                 1645                 1650             


Trp Ser  Glu Thr Asn Leu Leu  Cys Gly Cys Cys Leu  Leu Gln Arg 
    1655                 1660                 1665             


Arg Lys  Pro Val Leu Ser Phe  Gln Arg Gly His Leu  Arg Pro Arg 
    1670                 1675                 1680             


Ala Thr  His Leu Ile Ser Trp  Ser Gly Ser His Val  Gly Leu Cys 
    1685                 1690                 1695             


Thr Gly  Pro Cys Glu Met Ala  Glu Gln Arg Phe Cys  Val Asp Tyr 
    1700                 1705                 1710             


Ala Lys  Arg Gly Thr Ala Gly  Cys Lys Lys Cys Lys  Glu Lys Ile 
    1715                 1720                 1725             


Val Lys  Gly Val Cys Arg Ile  Gly Lys Val Val Pro  Asn Pro Phe 
    1730                 1735                 1740             


Ser Glu  Ser Gly Gly Asp Met  Lys Glu Trp Tyr His  Ile Lys Cys 
    1745                 1750                 1755             


Met Phe  Glu Lys Leu Glu Arg  Ala Arg Ala Thr Thr  Lys Lys Ile 
    1760                 1765                 1770             


Glu Asp  Leu Thr Glu Leu Glu  Gly Trp Glu Glu Leu  Glu Asp Asn 
    1775                 1780                 1785             


Glu Lys  Glu Gln Ile Ser Gln  His Ile Ala Asp Leu  Ser Ser Lys 
    1790                 1795                 1800             


Thr Ala  Ala Thr Pro Lys Lys  Lys Ala Thr Val Gln  Ala Lys Leu 
    1805                 1810                 1815             


Thr Thr  Thr Gly Gln Val Thr  Ser Pro Val Lys Gly  Ala Ser Phe 
    1820                 1825                 1830             


Ile Thr  Ser Thr Asn Pro Arg  Lys Phe Ser Gly Phe  Ser Ala Ala 
    1835                 1840                 1845             


Lys Pro  Asn Asn Ser Glu Gln  Asp Pro Ser Ser Pro  Ala Pro Lys 
    1850                 1855                 1860             


Thr Ser  Leu Ser Ala Ser Lys  Cys Asp Pro Lys His  Lys Asp Cys 
    1865                 1870                 1875             


Leu Leu  Arg Glu Phe Arg Lys  Leu Cys Ala Met Val  Ala Glu Asn 
    1880                 1885                 1890             


Pro Ser  Tyr Asn Thr Lys Thr  Gln Ile Ile His Asp  Phe Leu Gln 
    1895                 1900                 1905             


Lys Gly  Ser Thr Gly Asp Gly  Phe Arg Gly Asp Val  Tyr Leu Thr 
    1910                 1915                 1920             


Val Lys  Leu Leu Leu Pro Gly  Val Ile Lys Ser Val  Tyr Asn Leu 
    1925                 1930                 1935             


Asn Asp  Lys Gln Ile Val Lys  Leu Phe Ser Arg Ile  Phe Asn Cys 
    1940                 1945                 1950             


Asn Pro  Asp Asp Met Ala Arg  Asp Leu Glu Gln Gly  Asp Val Ser 
    1955                 1960                 1965             


Glu Thr  Ile Arg Val Phe Phe  Glu Gln Ser Lys Ser  Phe Pro Pro 
    1970                 1975                 1980             


Ala Ala  Lys Ser Leu Leu Thr  Ile Gln Glu Val Asp  Ala Phe Leu 
    1985                 1990                 1995             


Leu His  Leu Ser Lys Leu Thr  Lys Glu Asp Glu Gln  Gln Gln Ala 
    2000                 2005                 2010             


Leu Gln  Asp Ile Ala Ser Arg  Cys Thr Ala Asn Asp  Leu Lys Cys 
    2015                 2020                 2025             


Ile Ile  Arg Leu Ile Lys His  Asp Leu Lys Met Asn  Ser Gly Ala 
    2030                 2035                 2040             


Lys His  Val Leu Asp Ala Leu  Asp Pro Asn Ala Tyr  Glu Ala Phe 
    2045                 2050                 2055             


Lys Ala  Ser Arg Asn Leu Gln  Asp Val Val Glu Arg  Val Leu His 
    2060                 2065                 2070             


Asn Glu  Gln Glu Val Glu Lys  Asp Pro Gly Arg Arg  Arg Ala Leu 
    2075                 2080                 2085             


Ser Val  Gln Ala Ser Leu Met  Thr Pro Val Gln Pro  Met Leu Ala 
    2090                 2095                 2100             


Glu Ala  Cys Lys Ser Ile Glu  Tyr Ala Met Lys Lys  Cys Pro Asn 
    2105                 2110                 2115             


Gly Met  Phe Ser Glu Ile Lys  Tyr Asp Gly Glu Arg  Val Gln Val 
    2120                 2125                 2130             


His Lys  Lys Gly Asp His Phe  Ser Tyr Phe Ser Arg  Ser Leu Lys 
    2135                 2140                 2145             


Pro Val  Leu Pro His Lys Val  Ala His Phe Lys Asp  Tyr Ile Pro 
    2150                 2155                 2160             


Lys Ala  Phe Pro Gly Gly Gln  Ser Met Ile Leu Asp  Ser Glu Val 
    2165                 2170                 2175             


Leu Leu  Ile Asp Asn Asn Thr  Gly Lys Pro Leu Pro  Phe Gly Thr 
    2180                 2185                 2190             


Leu Gly  Val His Lys Lys Ala  Ala Phe Gln Asp Ala  Asn Val Cys 
    2195                 2200                 2205             


Leu Phe  Val Phe Asp Cys Ile  Tyr Phe Asn Asp Val  Ser Leu Met 
    2210                 2215                 2220             


Asp Arg  Pro Leu Cys Glu Arg  Arg Lys Phe Leu His  Asp Asn Met 
    2225                 2230                 2235             


Val Glu  Ile Arg Asn Arg Ile  Met Phe Ser Glu Met  Lys Gln Val 
    2240                 2245                 2250             


Thr Lys  Ala Ser Asp Leu Ala  Asp Met Ile Asn Arg  Val Ile Arg 
    2255                 2260                 2265             


Glu Gly  Leu Glu Gly Leu Val  Leu Lys Asp Val Lys  Gly Thr Tyr 
    2270                 2275                 2280             


Glu Pro  Gly Lys Arg His Trp  Leu Lys Val Lys Lys  Asp Tyr Leu 
    2285                 2290                 2295             


Asn Glu  Gly Ala Met Ala Asp  Thr Ala Asp Leu Val  Val Leu Gly 
    2300                 2305                 2310             


Ala Phe  Tyr Gly Gln Gly Ser  Lys Gly Gly Met Met  Ser Ile Phe 
    2315                 2320                 2325             


Leu Met  Gly Cys Tyr Asp Pro  Asp Ser Gln Lys Trp  Cys Thr Val 
    2330                 2335                 2340             


Thr Lys  Cys Ala Gly Gly His  Asp Asp Ala Thr Leu  Ala Arg Leu 
    2345                 2350                 2355             


Gln Lys  Glu Leu Asp Met Val  Lys Ile Ser Lys Asp  Pro Ser Lys 
    2360                 2365                 2370             


Ile Pro  Ser Trp Leu Lys Ile  Asn Lys Ile Tyr Tyr  Pro Asp Phe 
    2375                 2380                 2385             


Ile Val  Pro Asp Pro Lys Lys  Ala Ala Val Trp Glu  Ile Thr Gly 
    2390                 2395                 2400             


Ala Glu  Phe Ser Arg Ser Glu  Ala His Thr Ala Asp  Gly Ile Ser 
    2405                 2410                 2415             


Ile Arg  Phe Pro Arg Cys Thr  Arg Ile Arg Asp Asp  Lys Asp Trp 
    2420                 2425                 2430             


Lys Ser  Ala Thr Asn Leu Pro  Gln Leu Lys Glu Leu  Tyr Gln Leu 
    2435                 2440                 2445             


Ser Lys  Asp Lys Ala Asp Phe  Ala Val Val Ala Gly  Asp Glu Gly 
    2450                 2455                 2460             


Ser Ser  Thr Thr Gly Gly Ser  Asn Gly Glu Asn Glu  Gly Thr Ala 
    2465                 2470                 2475             


Gly Ser  Thr Val Pro Arg Lys  Gly Pro Lys Gly Pro  Pro Ser Lys 
    2480                 2485                 2490             


Ser Ser  Ala Ser Ala Lys Lys  Thr Glu Gln Lys Leu  Asn Asp Pro 
    2495                 2500                 2505             


Ser Ser  Arg Gly Gly Glu Lys  Leu Ala Val Lys Ser  Ser Pro Val 
    2510                 2515                 2520             


Lys Val  Gly Met Lys Arg Lys  Ala Ala Asp Glu Thr  Pro Gly Leu 
    2525                 2530                 2535             


Thr Lys  Arg Arg Arg Ala Ser  Arg Gln Arg Gly Arg  Arg Ala Met 
    2540                 2545                 2550             


Arg Thr  Gly Arg Arg Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    2555                 2560                 2565             


Val 
    


<210>  67
<211>  2569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, rLIG3


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  wtCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(2558)
<223>  rLIG3

<400>  67

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Leu Ala Phe  Lys Thr Leu 
    1610                 1615                 1620             


Phe Pro  Arg Asn Leu Cys Ala  Leu Gly Arg Lys Glu  Leu Cys Leu 
    1625                 1630                 1635             


Phe Ser  Glu Gln His His Trp  Pro Ala Ile Arg Gln  Phe Ser Gln 
    1640                 1645                 1650             


Trp Ser  Glu Thr Asn Leu Leu  Cys Gly Cys Cys Leu  Leu Gln Arg 
    1655                 1660                 1665             


Arg Lys  Pro Val Leu Ser Phe  Gln Arg Gly His Leu  Arg Pro Arg 
    1670                 1675                 1680             


Ala Thr  His Leu Ile Ser Trp  Ser Gly Ser His Val  Gly Leu Cys 
    1685                 1690                 1695             


Thr Gly  Pro Cys Glu Met Ala  Glu Gln Arg Phe Cys  Val Asp Tyr 
    1700                 1705                 1710             


Ala Lys  Arg Gly Thr Ala Gly  Cys Lys Lys Cys Lys  Glu Lys Ile 
    1715                 1720                 1725             


Val Lys  Gly Val Cys Arg Ile  Gly Lys Val Val Pro  Asn Pro Phe 
    1730                 1735                 1740             


Ser Glu  Ser Gly Gly Asp Met  Lys Glu Trp Tyr His  Ile Lys Cys 
    1745                 1750                 1755             


Met Phe  Glu Lys Leu Glu Arg  Ala Arg Ala Thr Thr  Lys Lys Ile 
    1760                 1765                 1770             


Glu Asp  Leu Thr Glu Leu Glu  Gly Trp Glu Glu Leu  Glu Asp Asn 
    1775                 1780                 1785             


Glu Lys  Glu Gln Ile Ser Gln  His Ile Ala Asp Leu  Ser Ser Lys 
    1790                 1795                 1800             


Thr Ala  Ala Thr Pro Lys Lys  Lys Ala Thr Val Gln  Ala Lys Leu 
    1805                 1810                 1815             


Thr Thr  Thr Gly Gln Val Thr  Ser Pro Val Lys Gly  Ala Ser Phe 
    1820                 1825                 1830             


Ile Thr  Ser Thr Asn Pro Arg  Lys Phe Ser Gly Phe  Ser Ala Ala 
    1835                 1840                 1845             


Lys Pro  Asn Asn Ser Glu Gln  Asp Pro Ser Ser Pro  Ala Pro Lys 
    1850                 1855                 1860             


Thr Ser  Leu Ser Ala Ser Lys  Cys Asp Pro Lys His  Lys Asp Cys 
    1865                 1870                 1875             


Leu Leu  Arg Glu Phe Arg Lys  Leu Cys Ala Met Val  Ala Glu Asn 
    1880                 1885                 1890             


Pro Ser  Tyr Asn Thr Lys Thr  Gln Ile Ile His Asp  Phe Leu Gln 
    1895                 1900                 1905             


Lys Gly  Ser Thr Gly Asp Gly  Phe Arg Gly Asp Val  Tyr Leu Thr 
    1910                 1915                 1920             


Val Lys  Leu Leu Leu Pro Gly  Val Ile Lys Ser Val  Tyr Asn Leu 
    1925                 1930                 1935             


Asn Asp  Lys Gln Ile Val Lys  Leu Phe Ser Arg Ile  Phe Asn Cys 
    1940                 1945                 1950             


Asn Pro  Asp Asp Met Ala Arg  Asp Leu Glu Gln Gly  Asp Val Ser 
    1955                 1960                 1965             


Glu Thr  Ile Arg Val Phe Phe  Glu Gln Ser Lys Ser  Phe Pro Pro 
    1970                 1975                 1980             


Ala Ala  Lys Ser Leu Leu Thr  Ile Gln Glu Val Asp  Ala Phe Leu 
    1985                 1990                 1995             


Leu His  Leu Ser Lys Leu Thr  Lys Glu Asp Glu Gln  Gln Gln Ala 
    2000                 2005                 2010             


Leu Gln  Asp Ile Ala Ser Arg  Cys Thr Ala Asn Asp  Leu Lys Cys 
    2015                 2020                 2025             


Ile Ile  Arg Leu Ile Lys His  Asp Leu Lys Met Asn  Ser Gly Ala 
    2030                 2035                 2040             


Lys His  Val Leu Asp Ala Leu  Asp Pro Asn Ala Tyr  Glu Ala Phe 
    2045                 2050                 2055             


Lys Ala  Ser Arg Asn Leu Gln  Asp Val Val Glu Arg  Val Leu His 
    2060                 2065                 2070             


Asn Glu  Gln Glu Val Glu Lys  Asp Pro Gly Arg Arg  Arg Ala Leu 
    2075                 2080                 2085             


Ser Val  Gln Ala Ser Leu Met  Thr Pro Val Gln Pro  Met Leu Ala 
    2090                 2095                 2100             


Glu Ala  Cys Lys Ser Ile Glu  Tyr Ala Met Lys Lys  Cys Pro Asn 
    2105                 2110                 2115             


Gly Met  Phe Ser Glu Ile Lys  Tyr Asp Gly Glu Arg  Val Gln Val 
    2120                 2125                 2130             


His Lys  Lys Gly Asp His Phe  Ser Tyr Phe Ser Arg  Ser Leu Lys 
    2135                 2140                 2145             


Pro Val  Leu Pro His Lys Val  Ala His Phe Lys Asp  Tyr Ile Pro 
    2150                 2155                 2160             


Lys Ala  Phe Pro Gly Gly Gln  Ser Met Ile Leu Asp  Ser Glu Val 
    2165                 2170                 2175             


Leu Leu  Ile Asp Asn Asn Thr  Gly Lys Pro Leu Pro  Phe Gly Thr 
    2180                 2185                 2190             


Leu Gly  Val His Lys Lys Ala  Ala Phe Gln Asp Ala  Asn Val Cys 
    2195                 2200                 2205             


Leu Phe  Val Phe Asp Cys Ile  Tyr Phe Asn Asp Val  Ser Leu Met 
    2210                 2215                 2220             


Asp Arg  Pro Leu Cys Glu Arg  Arg Lys Phe Leu His  Asp Asn Met 
    2225                 2230                 2235             


Val Glu  Ile Arg Asn Arg Ile  Met Phe Ser Glu Met  Lys Gln Val 
    2240                 2245                 2250             


Thr Lys  Ala Ser Asp Leu Ala  Asp Met Ile Asn Arg  Val Ile Arg 
    2255                 2260                 2265             


Glu Gly  Leu Glu Gly Leu Val  Leu Lys Asp Val Lys  Gly Thr Tyr 
    2270                 2275                 2280             


Glu Pro  Gly Lys Arg His Trp  Leu Lys Val Lys Lys  Asp Tyr Leu 
    2285                 2290                 2295             


Asn Glu  Gly Ala Met Ala Asp  Thr Ala Asp Leu Val  Val Leu Gly 
    2300                 2305                 2310             


Ala Phe  Tyr Gly Gln Gly Ser  Lys Gly Gly Met Met  Ser Ile Phe 
    2315                 2320                 2325             


Leu Met  Gly Cys Tyr Asp Pro  Asp Ser Gln Lys Trp  Cys Thr Val 
    2330                 2335                 2340             


Thr Lys  Cys Ala Gly Gly His  Asp Asp Ala Thr Leu  Ala Arg Leu 
    2345                 2350                 2355             


Gln Lys  Glu Leu Asp Met Val  Lys Ile Ser Lys Asp  Pro Ser Lys 
    2360                 2365                 2370             


Ile Pro  Ser Trp Leu Lys Ile  Asn Lys Ile Tyr Tyr  Pro Asp Phe 
    2375                 2380                 2385             


Ile Val  Pro Asp Pro Lys Lys  Ala Ala Val Trp Glu  Ile Thr Gly 
    2390                 2395                 2400             


Ala Glu  Phe Ser Arg Ser Glu  Ala His Thr Ala Asp  Gly Ile Ser 
    2405                 2410                 2415             


Ile Arg  Phe Pro Arg Cys Thr  Arg Ile Arg Asp Asp  Lys Asp Trp 
    2420                 2425                 2430             


Lys Ser  Ala Thr Asn Leu Pro  Gln Leu Lys Glu Leu  Tyr Gln Leu 
    2435                 2440                 2445             


Ser Lys  Asp Lys Ala Asp Phe  Ala Val Val Ala Gly  Asp Glu Gly 
    2450                 2455                 2460             


Ser Ser  Thr Thr Gly Gly Ser  Asn Gly Glu Asn Glu  Gly Thr Ala 
    2465                 2470                 2475             


Gly Ser  Thr Val Pro Arg Lys  Gly Pro Lys Gly Pro  Pro Ser Lys 
    2480                 2485                 2490             


Ser Ser  Ala Ser Ala Lys Lys  Thr Glu Gln Lys Leu  Asn Asp Pro 
    2495                 2500                 2505             


Ser Ser  Arg Gly Gly Glu Lys  Leu Ala Val Lys Ser  Ser Pro Val 
    2510                 2515                 2520             


Lys Val  Gly Met Lys Arg Lys  Ala Ala Asp Glu Thr  Pro Gly Leu 
    2525                 2530                 2535             


Thr Lys  Arg Arg Arg Ala Ser  Arg Gln Arg Gly Arg  Arg Ala Met 
    2540                 2545                 2550             


Arg Thr  Gly Arg Arg Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    2555                 2560                 2565             


Val 
    


<210>  68
<211>  2569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAC, rLIG3


<220>
<221>  MISC_FEATURE
<222>  (1)..(943)
<223>  rLIG3

<220>
<221>  MISC_FEATURE
<222>  (948)..(1175)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (1192)..(2558)
<223>  nCas9

<400>  68

Met Thr Leu Ala Phe Lys Thr Leu Phe Pro Arg Asn Leu Cys Ala Leu 
1               5                   10                  15      


Gly Arg Lys Glu Leu Cys Leu Phe Ser Glu Gln His His Trp Pro Ala 
            20                  25                  30          


Ile Arg Gln Phe Ser Gln Trp Ser Glu Thr Asn Leu Leu Cys Gly Cys 
        35                  40                  45              


Cys Leu Leu Gln Arg Arg Lys Pro Val Leu Ser Phe Gln Arg Gly His 
    50                  55                  60                  


Leu Arg Pro Arg Ala Thr His Leu Ile Ser Trp Ser Gly Ser His Val 
65                  70                  75                  80  


Gly Leu Cys Thr Gly Pro Cys Glu Met Ala Glu Gln Arg Phe Cys Val 
                85                  90                  95      


Asp Tyr Ala Lys Arg Gly Thr Ala Gly Cys Lys Lys Cys Lys Glu Lys 
            100                 105                 110         


Ile Val Lys Gly Val Cys Arg Ile Gly Lys Val Val Pro Asn Pro Phe 
        115                 120                 125             


Ser Glu Ser Gly Gly Asp Met Lys Glu Trp Tyr His Ile Lys Cys Met 
    130                 135                 140                 


Phe Glu Lys Leu Glu Arg Ala Arg Ala Thr Thr Lys Lys Ile Glu Asp 
145                 150                 155                 160 


Leu Thr Glu Leu Glu Gly Trp Glu Glu Leu Glu Asp Asn Glu Lys Glu 
                165                 170                 175     


Gln Ile Ser Gln His Ile Ala Asp Leu Ser Ser Lys Thr Ala Ala Thr 
            180                 185                 190         


Pro Lys Lys Lys Ala Thr Val Gln Ala Lys Leu Thr Thr Thr Gly Gln 
        195                 200                 205             


Val Thr Ser Pro Val Lys Gly Ala Ser Phe Ile Thr Ser Thr Asn Pro 
    210                 215                 220                 


Arg Lys Phe Ser Gly Phe Ser Ala Ala Lys Pro Asn Asn Ser Glu Gln 
225                 230                 235                 240 


Asp Pro Ser Ser Pro Ala Pro Lys Thr Ser Leu Ser Ala Ser Lys Cys 
                245                 250                 255     


Asp Pro Lys His Lys Asp Cys Leu Leu Arg Glu Phe Arg Lys Leu Cys 
            260                 265                 270         


Ala Met Val Ala Glu Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile 
        275                 280                 285             


His Asp Phe Leu Gln Lys Gly Ser Thr Gly Asp Gly Phe Arg Gly Asp 
    290                 295                 300                 


Val Tyr Leu Thr Val Lys Leu Leu Leu Pro Gly Val Ile Lys Ser Val 
305                 310                 315                 320 


Tyr Asn Leu Asn Asp Lys Gln Ile Val Lys Leu Phe Ser Arg Ile Phe 
                325                 330                 335     


Asn Cys Asn Pro Asp Asp Met Ala Arg Asp Leu Glu Gln Gly Asp Val 
            340                 345                 350         


Ser Glu Thr Ile Arg Val Phe Phe Glu Gln Ser Lys Ser Phe Pro Pro 
        355                 360                 365             


Ala Ala Lys Ser Leu Leu Thr Ile Gln Glu Val Asp Ala Phe Leu Leu 
    370                 375                 380                 


His Leu Ser Lys Leu Thr Lys Glu Asp Glu Gln Gln Gln Ala Leu Gln 
385                 390                 395                 400 


Asp Ile Ala Ser Arg Cys Thr Ala Asn Asp Leu Lys Cys Ile Ile Arg 
                405                 410                 415     


Leu Ile Lys His Asp Leu Lys Met Asn Ser Gly Ala Lys His Val Leu 
            420                 425                 430         


Asp Ala Leu Asp Pro Asn Ala Tyr Glu Ala Phe Lys Ala Ser Arg Asn 
        435                 440                 445             


Leu Gln Asp Val Val Glu Arg Val Leu His Asn Glu Gln Glu Val Glu 
    450                 455                 460                 


Lys Asp Pro Gly Arg Arg Arg Ala Leu Ser Val Gln Ala Ser Leu Met 
465                 470                 475                 480 


Thr Pro Val Gln Pro Met Leu Ala Glu Ala Cys Lys Ser Ile Glu Tyr 
                485                 490                 495     


Ala Met Lys Lys Cys Pro Asn Gly Met Phe Ser Glu Ile Lys Tyr Asp 
            500                 505                 510         


Gly Glu Arg Val Gln Val His Lys Lys Gly Asp His Phe Ser Tyr Phe 
        515                 520                 525             


Ser Arg Ser Leu Lys Pro Val Leu Pro His Lys Val Ala His Phe Lys 
    530                 535                 540                 


Asp Tyr Ile Pro Lys Ala Phe Pro Gly Gly Gln Ser Met Ile Leu Asp 
545                 550                 555                 560 


Ser Glu Val Leu Leu Ile Asp Asn Asn Thr Gly Lys Pro Leu Pro Phe 
                565                 570                 575     


Gly Thr Leu Gly Val His Lys Lys Ala Ala Phe Gln Asp Ala Asn Val 
            580                 585                 590         


Cys Leu Phe Val Phe Asp Cys Ile Tyr Phe Asn Asp Val Ser Leu Met 
        595                 600                 605             


Asp Arg Pro Leu Cys Glu Arg Arg Lys Phe Leu His Asp Asn Met Val 
    610                 615                 620                 


Glu Ile Arg Asn Arg Ile Met Phe Ser Glu Met Lys Gln Val Thr Lys 
625                 630                 635                 640 


Ala Ser Asp Leu Ala Asp Met Ile Asn Arg Val Ile Arg Glu Gly Leu 
                645                 650                 655     


Glu Gly Leu Val Leu Lys Asp Val Lys Gly Thr Tyr Glu Pro Gly Lys 
            660                 665                 670         


Arg His Trp Leu Lys Val Lys Lys Asp Tyr Leu Asn Glu Gly Ala Met 
        675                 680                 685             


Ala Asp Thr Ala Asp Leu Val Val Leu Gly Ala Phe Tyr Gly Gln Gly 
    690                 695                 700                 


Ser Lys Gly Gly Met Met Ser Ile Phe Leu Met Gly Cys Tyr Asp Pro 
705                 710                 715                 720 


Asp Ser Gln Lys Trp Cys Thr Val Thr Lys Cys Ala Gly Gly His Asp 
                725                 730                 735     


Asp Ala Thr Leu Ala Arg Leu Gln Lys Glu Leu Asp Met Val Lys Ile 
            740                 745                 750         


Ser Lys Asp Pro Ser Lys Ile Pro Ser Trp Leu Lys Ile Asn Lys Ile 
        755                 760                 765             


Tyr Tyr Pro Asp Phe Ile Val Pro Asp Pro Lys Lys Ala Ala Val Trp 
    770                 775                 780                 


Glu Ile Thr Gly Ala Glu Phe Ser Arg Ser Glu Ala His Thr Ala Asp 
785                 790                 795                 800 


Gly Ile Ser Ile Arg Phe Pro Arg Cys Thr Arg Ile Arg Asp Asp Lys 
                805                 810                 815     


Asp Trp Lys Ser Ala Thr Asn Leu Pro Gln Leu Lys Glu Leu Tyr Gln 
            820                 825                 830         


Leu Ser Lys Asp Lys Ala Asp Phe Ala Val Val Ala Gly Asp Glu Gly 
        835                 840                 845             


Ser Ser Thr Thr Gly Gly Ser Asn Gly Glu Asn Glu Gly Thr Ala Gly 
    850                 855                 860                 


Ser Thr Val Pro Arg Lys Gly Pro Lys Gly Pro Pro Ser Lys Ser Ser 
865                 870                 875                 880 


Ala Ser Ala Lys Lys Thr Glu Gln Lys Leu Asn Asp Pro Ser Ser Arg 
                885                 890                 895     


Gly Gly Glu Lys Leu Ala Val Lys Ser Ser Pro Val Lys Val Gly Met 
            900                 905                 910         


Lys Arg Lys Ala Ala Asp Glu Thr Pro Gly Leu Thr Lys Arg Arg Arg 
        915                 920                 925             


Ala Ser Arg Gln Arg Gly Arg Arg Ala Met Arg Thr Gly Arg Arg Ser 
    930                 935                 940                 


Gly Gly Ser Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu 
945                 950                 955                 960 


Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg 
                965                 970                 975     


Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly 
            980                 985                 990         


Arg His Ser Ile Trp Arg His Thr  Ser Gln Asn Thr Asn  Lys His Val 
        995                 1000                 1005             


Glu Val  Asn Phe Ile Glu Lys  Phe Thr Thr Glu Arg  Tyr Phe Cys 
    1010                 1015                 1020             


Pro Asn  Thr Arg Cys Ser Ile  Thr Trp Phe Leu Ser  Trp Ser Pro 
    1025                 1030                 1035             


Cys Gly  Glu Cys Ser Arg Ala  Ile Thr Glu Phe Leu  Ser Arg Tyr 
    1040                 1045                 1050             


Pro His  Val Thr Leu Phe Ile  Tyr Ile Ala Arg Leu  Tyr His His 
    1055                 1060                 1065             


Ala Asp  Pro Arg Asn Arg Gln  Gly Leu Arg Asp Leu  Ile Ser Ser 
    1070                 1075                 1080             


Gly Val  Thr Ile Gln Ile Met  Thr Glu Gln Glu Ser  Gly Tyr Cys 
    1085                 1090                 1095             


Trp Arg  Asn Phe Val Asn Tyr  Ser Pro Ser Asn Glu  Ala His Trp 
    1100                 1105                 1110             


Pro Arg  Tyr Pro His Leu Trp  Val Arg Leu Tyr Val  Leu Glu Leu 
    1115                 1120                 1125             


Tyr Cys  Ile Ile Leu Gly Leu  Pro Pro Cys Leu Asn  Ile Leu Arg 
    1130                 1135                 1140             


Arg Lys  Gln Pro Gln Leu Thr  Phe Phe Thr Ile Ala  Leu Gln Ser 
    1145                 1150                 1155             


Cys His  Tyr Gln Arg Leu Pro  Pro His Ile Leu Trp  Ala Thr Gly 
    1160                 1165                 1170             


Leu Lys  Ser Gly Ser Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr 
    1175                 1180                 1185             


Pro Glu  Ser Asp Lys Lys Tyr  Ser Ile Gly Leu Ala  Ile Gly Thr 
    1190                 1195                 1200             


Asn Ser  Val Gly Trp Ala Val  Ile Thr Asp Glu Tyr  Lys Val Pro 
    1205                 1210                 1215             


Ser Lys  Lys Phe Lys Val Leu  Gly Asn Thr Asp Arg  His Ser Ile 
    1220                 1225                 1230             


Lys Lys  Asn Leu Ile Gly Ala  Leu Leu Phe Asp Ser  Gly Glu Thr 
    1235                 1240                 1245             


Ala Glu  Ala Thr Arg Leu Lys  Arg Thr Ala Arg Arg  Arg Tyr Thr 
    1250                 1255                 1260             


Arg Arg  Lys Asn Arg Ile Cys  Tyr Leu Gln Glu Ile  Phe Ser Asn 
    1265                 1270                 1275             


Glu Met  Ala Lys Val Asp Asp  Ser Phe Phe His Arg  Leu Glu Glu 
    1280                 1285                 1290             


Ser Phe  Leu Val Glu Glu Asp  Lys Lys His Glu Arg  His Pro Ile 
    1295                 1300                 1305             


Phe Gly  Asn Ile Val Asp Glu  Val Ala Tyr His Glu  Lys Tyr Pro 
    1310                 1315                 1320             


Thr Ile  Tyr His Leu Arg Lys  Lys Leu Val Asp Ser  Thr Asp Lys 
    1325                 1330                 1335             


Ala Asp  Leu Arg Leu Ile Tyr  Leu Ala Leu Ala His  Met Ile Lys 
    1340                 1345                 1350             


Phe Arg  Gly His Phe Leu Ile  Glu Gly Asp Leu Asn  Pro Asp Asn 
    1355                 1360                 1365             


Ser Asp  Val Asp Lys Leu Phe  Ile Gln Leu Val Gln  Thr Tyr Asn 
    1370                 1375                 1380             


Gln Leu  Phe Glu Glu Asn Pro  Ile Asn Ala Ser Gly  Val Asp Ala 
    1385                 1390                 1395             


Lys Ala  Ile Leu Ser Ala Arg  Leu Ser Lys Ser Arg  Arg Leu Glu 
    1400                 1405                 1410             


Asn Leu  Ile Ala Gln Leu Pro  Gly Glu Lys Lys Asn  Gly Leu Phe 
    1415                 1420                 1425             


Gly Asn  Leu Ile Ala Leu Ser  Leu Gly Leu Thr Pro  Asn Phe Lys 
    1430                 1435                 1440             


Ser Asn  Phe Asp Leu Ala Glu  Asp Ala Lys Leu Gln  Leu Ser Lys 
    1445                 1450                 1455             


Asp Thr  Tyr Asp Asp Asp Leu  Asp Asn Leu Leu Ala  Gln Ile Gly 
    1460                 1465                 1470             


Asp Gln  Tyr Ala Asp Leu Phe  Leu Ala Ala Lys Asn  Leu Ser Asp 
    1475                 1480                 1485             


Ala Ile  Leu Leu Ser Asp Ile  Leu Arg Val Asn Thr  Glu Ile Thr 
    1490                 1495                 1500             


Lys Ala  Pro Leu Ser Ala Ser  Met Ile Lys Arg Tyr  Asp Glu His 
    1505                 1510                 1515             


His Gln  Asp Leu Thr Leu Leu  Lys Ala Leu Val Arg  Gln Gln Leu 
    1520                 1525                 1530             


Pro Glu  Lys Tyr Lys Glu Ile  Phe Phe Asp Gln Ser  Lys Asn Gly 
    1535                 1540                 1545             


Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser Gln Glu  Glu Phe Tyr 
    1550                 1555                 1560             


Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met Asp Gly  Thr Glu Glu 
    1565                 1570                 1575             


Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu Leu Arg  Lys Gln Arg 
    1580                 1585                 1590             


Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln Ile His  Leu Gly Glu 
    1595                 1600                 1605             


Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp Phe Tyr  Pro Phe Leu 
    1610                 1615                 1620             


Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile Leu Thr  Phe Arg Ile 
    1625                 1630                 1635             


Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly Asn Ser  Arg Phe Ala 
    1640                 1645                 1650             


Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile Thr Pro  Trp Asn Phe 
    1655                 1660                 1665             


Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala Gln Ser  Phe Ile Glu 
    1670                 1675                 1680             


Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro Asn Glu  Lys Val Leu 
    1685                 1690                 1695             


Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe Thr Val  Tyr Asn Glu 
    1700                 1705                 1710             


Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly Met Arg  Lys Pro Ala 
    1715                 1720                 1725             


Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile Val Asp  Leu Leu Phe 
    1730                 1735                 1740             


Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln Leu Lys  Glu Asp Tyr 
    1745                 1750                 1755             


Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val Glu Ile  Ser Gly Val 
    1760                 1765                 1770             


Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr Tyr His  Asp Leu Leu 
    1775                 1780                 1785             


Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp Asn Glu  Glu Asn Glu 
    1790                 1795                 1800             


Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu Thr Leu  Phe Glu Asp 
    1805                 1810                 1815             


Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr Tyr Ala  His Leu Phe 
    1820                 1825                 1830             


Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg Arg Arg  Tyr Thr Gly 
    1835                 1840                 1845             


Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn Gly Ile  Arg Asp Lys 
    1850                 1855                 1860             


Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu Lys Ser  Asp Gly Phe 
    1865                 1870                 1875             


Ala Asn  Arg Asn Phe Met Gln  Leu Ile His Asp Asp  Ser Leu Thr 
    1880                 1885                 1890             


Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val Ser Gly  Gln Gly Asp 
    1895                 1900                 1905             


Ser Leu  His Glu His Ile Ala  Asn Leu Ala Gly Ser  Pro Ala Ile 
    1910                 1915                 1920             


Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val Val Asp  Glu Leu Val 
    1925                 1930                 1935             


Lys Val  Met Gly Arg His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    1940                 1945                 1950             


Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg 
    1955                 1960                 1965             


Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser 
    1970                 1975                 1980             


Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    1985                 1990                 1995             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    2000                 2005                 2010             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    2015                 2020                 2025             


Asp His  Ile Val Pro Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp 
    2030                 2035                 2040             


Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
    2045                 2050                 2055             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    2060                 2065                 2070             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    2075                 2080                 2085             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    2090                 2095                 2100             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    2105                 2110                 2115             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    2120                 2125                 2130             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    2135                 2140                 2145             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    2150                 2155                 2160             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    2165                 2170                 2175             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    2180                 2185                 2190             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    2195                 2200                 2205             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    2210                 2215                 2220             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    2225                 2230                 2235             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    2240                 2245                 2250             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    2255                 2260                 2265             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    2270                 2275                 2280             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    2285                 2290                 2295             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    2300                 2305                 2310             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    2315                 2320                 2325             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    2330                 2335                 2340             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    2345                 2350                 2355             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    2360                 2365                 2370             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    2375                 2380                 2385             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    2390                 2395                 2400             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    2405                 2410                 2415             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    2420                 2425                 2430             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    2435                 2440                 2445             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    2450                 2455                 2460             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    2465                 2470                 2475             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    2480                 2485                 2490             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    2495                 2500                 2505             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    2510                 2515                 2520             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    2525                 2530                 2535             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    2540                 2545                 2550             


Gln Leu  Gly Gly Asp Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    2555                 2560                 2565             


Val 
    


<210>  69
<211>  2257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, rXRCC1


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  nCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(2246)
<223>  rXRCC1

<400>  69

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Pro Glu Ile Ser  Leu Arg His 
    1610                 1615                 1620             


Val Val  Ser Cys Ser Ser Gln  Asp Ser Thr His Arg  Ala Glu Asn 
    1625                 1630                 1635             


Leu Leu  Lys Ala Asp Thr Tyr  Arg Lys Trp Arg Ser  Ala Lys Ala 
    1640                 1645                 1650             


Gly Glu  Lys Thr Ile Ser Val  Val Leu Gln Leu Glu  Lys Glu Glu 
    1655                 1660                 1665             


Gln Ile  His Ser Val Asp Ile  Gly Asn Asp Gly Ser  Ala Phe Val 
    1670                 1675                 1680             


Glu Val  Leu Val Gly Ser Ser  Ala Gly Gly Ala Thr  Ala Gly Glu 
    1685                 1690                 1695             


Gln Asp  Tyr Glu Val Leu Leu  Val Thr Ser Ser Phe  Met Ser Pro 
    1700                 1705                 1710             


Ser Glu  Ser Arg Ser Gly Ser  Asn Pro Asn Arg Val  Arg Ile Phe 
    1715                 1720                 1725             


Gly Pro  Asp Lys Leu Val Arg  Ala Ala Ala Glu Lys  Arg Trp Asp 
    1730                 1735                 1740             


Arg Val  Lys Ile Val Cys Ser  Gln Pro Tyr Ser Lys  Asp Ser Pro 
    1745                 1750                 1755             


Tyr Gly  Leu Ser Phe Val Lys  Phe His Ser Pro Pro  Asp Lys Asp 
    1760                 1765                 1770             


Glu Ala  Glu Ala Pro Ser Gln  Lys Val Thr Val Thr  Lys Leu Gly 
    1775                 1780                 1785             


Gln Phe  Arg Val Lys Glu Glu  Asp Asp Ser Ala Asn  Ser Leu Arg 
    1790                 1795                 1800             


Pro Gly  Ala Leu Phe Phe Asn  Arg Ile Asn Lys Ala  Ala Ser Ala 
    1805                 1810                 1815             


Ser Ala  Ser Asp Pro Ala Gly  Pro Ser Tyr Ala Ala  Ala Thr Leu 
    1820                 1825                 1830             


Gln Ala  Ser Ser Ala Ala Ser  Ser Ala Leu Pro Val  Pro Lys Val 
    1835                 1840                 1845             


Gly Gly  Ser Ser Ser Lys Leu  Gln Glu Pro Pro Lys  Gly Lys Arg 
    1850                 1855                 1860             


Lys Leu  Asp Leu Gly Leu Glu  Asp Ser Lys Pro Pro  Ser Lys Pro 
    1865                 1870                 1875             


Ser Ala  Gly Pro Ala Ala Leu  Lys Arg Pro Lys Leu  Pro Val Pro 
    1880                 1885                 1890             


Ser Arg  Thr Pro Ala Ala Thr  Pro Ala Ser Thr Pro  Ala Gln Lys 
    1895                 1900                 1905             


Ala Val  Pro Gly Lys Pro Arg  Gly Glu Gly Thr Glu  Pro Arg Gly 
    1910                 1915                 1920             


Ala Arg  Ala Gly Pro Gln Glu  Leu Gly Lys Ile Leu  Gln Gly Val 
    1925                 1930                 1935             


Val Val  Val Leu Ser Gly Phe  Gln Asn Pro Phe Arg  Ser Glu Leu 
    1940                 1945                 1950             


Arg Asp  Lys Ala Leu Glu Leu  Gly Ala Lys Tyr Arg  Pro Asp Trp 
    1955                 1960                 1965             


Thr Pro  Asp Ser Thr His Leu  Ile Cys Ala Phe Ala  Asn Thr Pro 
    1970                 1975                 1980             


Lys Tyr  Ser Gln Val Leu Gly  Leu Gly Gly Arg Ile  Val Arg Lys 
    1985                 1990                 1995             


Glu Trp  Val Leu Asp Cys Tyr  Arg Met Arg Arg Arg  Leu Pro Ser 
    2000                 2005                 2010             


Arg Arg  Tyr Leu Met Ala Gly  Leu Gly Ser Ser Ser  Glu Asp Glu 
    2015                 2020                 2025             


Gly Asp  Ser His Ser Glu Ser  Gly Glu Asp Glu Ala  Pro Lys Leu 
    2030                 2035                 2040             


Pro Arg  Lys Arg Pro Gln Pro  Lys Ala Lys Thr Gln  Ala Ala Gly 
    2045                 2050                 2055             


Pro Ser  Ser Pro Pro Arg Pro  Pro Thr Pro Glu Glu  Thr Lys Ala 
    2060                 2065                 2070             


Pro Ser  Pro Gly Pro Gln Asp  Asn Ser Asp Thr Asp  Gly Glu Gln 
    2075                 2080                 2085             


Ser Glu  Gly Arg Asp Asn Gly  Ala Glu Asp Ser Gly  Asp Thr Glu 
    2090                 2095                 2100             


Asp Glu  Leu Arg Arg Val Ala  Lys Gln Arg Glu Gln  Arg Gln Pro 
    2105                 2110                 2115             


Pro Ala  Pro Glu Glu Asn Gly  Glu Asp Pro Tyr Ala  Gly Ser Thr 
    2120                 2125                 2130             


Asp Glu  Asn Thr Asp Ser Glu  Ala Pro Ser Glu Ala  Asp Leu Pro 
    2135                 2140                 2145             


Ile Pro  Glu Leu Pro Asp Phe  Phe Gln Gly Lys His  Phe Phe Leu 
    2150                 2155                 2160             


Tyr Gly  Glu Phe Pro Gly Asp  Glu Arg Arg Lys Leu  Ile Arg Tyr 
    2165                 2170                 2175             


Val Thr  Ala Phe Asn Gly Glu  Leu Glu Asp Tyr Met  Ser Asp Arg 
    2180                 2185                 2190             


Val Gln  Phe Val Ile Thr Ala  Gln Glu Trp Asp Pro  Asn Phe Glu 
    2195                 2200                 2205             


Glu Ala  Leu Met Glu Asn Pro  Ser Leu Ala Phe Val  Arg Pro Arg 
    2210                 2215                 2220             


Trp Ile  Tyr Ser Cys Asn Glu  Lys Gln Lys Leu Leu  Pro His Gln 
    2225                 2230                 2235             


Leu Tyr  Gly Val Val Pro Gln  Ala Ser Gly Gly Ser  Pro Lys Lys 
    2240                 2245                 2250             


Lys Arg  Lys Val 
    2255         


<210>  70
<211>  2257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACX, rXRCC1


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (246)..(1612)
<223>  wtCas9

<220>
<221>  MISC_FEATURE
<222>  (1617)..(2246)
<223>  rXRCC1

<400>  70

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
225                 230                 235                 240 


Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
                245                 250                 255     


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
            260                 265                 270         


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
        275                 280                 285             


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
    290                 295                 300                 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
305                 310                 315                 320 


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
                325                 330                 335     


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
            340                 345                 350         


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
        355                 360                 365             


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
    370                 375                 380                 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
385                 390                 395                 400 


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
                405                 410                 415     


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
            420                 425                 430         


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
        435                 440                 445             


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
    450                 455                 460                 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
465                 470                 475                 480 


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
                485                 490                 495     


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
            500                 505                 510         


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
        515                 520                 525             


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
    530                 535                 540                 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
545                 550                 555                 560 


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
                565                 570                 575     


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
            580                 585                 590         


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
        595                 600                 605             


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
    610                 615                 620                 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
625                 630                 635                 640 


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
                645                 650                 655     


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
            660                 665                 670         


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
        675                 680                 685             


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
    690                 695                 700                 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
705                 710                 715                 720 


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
                725                 730                 735     


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
            740                 745                 750         


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
        755                 760                 765             


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
    770                 775                 780                 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
785                 790                 795                 800 


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
                805                 810                 815     


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
            820                 825                 830         


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
        835                 840                 845             


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
    850                 855                 860                 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
865                 870                 875                 880 


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
                885                 890                 895     


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
            900                 905                 910         


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
        915                 920                 925             


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
    930                 935                 940                 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
945                 950                 955                 960 


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
                965                 970                 975     


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
            980                 985                 990         


Lys Val Met Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
        995                 1000                 1005             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1010                 1015                 1020             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1025                 1030                 1035             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1040                 1045                 1050             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1055                 1060                 1065             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1070                 1075                 1080             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1085                 1090                 1095             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1100                 1105                 1110             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1115                 1120                 1125             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1130                 1135                 1140             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1145                 1150                 1155             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1160                 1165                 1170             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1175                 1180                 1185             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1190                 1195                 1200             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1205                 1210                 1215             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1220                 1225                 1230             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1235                 1240                 1245             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1250                 1255                 1260             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1265                 1270                 1275             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1280                 1285                 1290             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1295                 1300                 1305             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1310                 1315                 1320             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1325                 1330                 1335             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1340                 1345                 1350             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1355                 1360                 1365             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1370                 1375                 1380             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1385                 1390                 1395             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1400                 1405                 1410             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1415                 1420                 1425             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1430                 1435                 1440             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1445                 1450                 1455             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1460                 1465                 1470             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1475                 1480                 1485             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1490                 1495                 1500             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1505                 1510                 1515             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1520                 1525                 1530             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1535                 1540                 1545             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1550                 1555                 1560             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1565                 1570                 1575             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1580                 1585                 1590             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1595                 1600                 1605             


Leu Gly  Gly Asp Ser Gly Gly  Ser Pro Glu Ile Ser  Leu Arg His 
    1610                 1615                 1620             


Val Val  Ser Cys Ser Ser Gln  Asp Ser Thr His Arg  Ala Glu Asn 
    1625                 1630                 1635             


Leu Leu  Lys Ala Asp Thr Tyr  Arg Lys Trp Arg Ser  Ala Lys Ala 
    1640                 1645                 1650             


Gly Glu  Lys Thr Ile Ser Val  Val Leu Gln Leu Glu  Lys Glu Glu 
    1655                 1660                 1665             


Gln Ile  His Ser Val Asp Ile  Gly Asn Asp Gly Ser  Ala Phe Val 
    1670                 1675                 1680             


Glu Val  Leu Val Gly Ser Ser  Ala Gly Gly Ala Thr  Ala Gly Glu 
    1685                 1690                 1695             


Gln Asp  Tyr Glu Val Leu Leu  Val Thr Ser Ser Phe  Met Ser Pro 
    1700                 1705                 1710             


Ser Glu  Ser Arg Ser Gly Ser  Asn Pro Asn Arg Val  Arg Ile Phe 
    1715                 1720                 1725             


Gly Pro  Asp Lys Leu Val Arg  Ala Ala Ala Glu Lys  Arg Trp Asp 
    1730                 1735                 1740             


Arg Val  Lys Ile Val Cys Ser  Gln Pro Tyr Ser Lys  Asp Ser Pro 
    1745                 1750                 1755             


Tyr Gly  Leu Ser Phe Val Lys  Phe His Ser Pro Pro  Asp Lys Asp 
    1760                 1765                 1770             


Glu Ala  Glu Ala Pro Ser Gln  Lys Val Thr Val Thr  Lys Leu Gly 
    1775                 1780                 1785             


Gln Phe  Arg Val Lys Glu Glu  Asp Asp Ser Ala Asn  Ser Leu Arg 
    1790                 1795                 1800             


Pro Gly  Ala Leu Phe Phe Asn  Arg Ile Asn Lys Ala  Ala Ser Ala 
    1805                 1810                 1815             


Ser Ala  Ser Asp Pro Ala Gly  Pro Ser Tyr Ala Ala  Ala Thr Leu 
    1820                 1825                 1830             


Gln Ala  Ser Ser Ala Ala Ser  Ser Ala Leu Pro Val  Pro Lys Val 
    1835                 1840                 1845             


Gly Gly  Ser Ser Ser Lys Leu  Gln Glu Pro Pro Lys  Gly Lys Arg 
    1850                 1855                 1860             


Lys Leu  Asp Leu Gly Leu Glu  Asp Ser Lys Pro Pro  Ser Lys Pro 
    1865                 1870                 1875             


Ser Ala  Gly Pro Ala Ala Leu  Lys Arg Pro Lys Leu  Pro Val Pro 
    1880                 1885                 1890             


Ser Arg  Thr Pro Ala Ala Thr  Pro Ala Ser Thr Pro  Ala Gln Lys 
    1895                 1900                 1905             


Ala Val  Pro Gly Lys Pro Arg  Gly Glu Gly Thr Glu  Pro Arg Gly 
    1910                 1915                 1920             


Ala Arg  Ala Gly Pro Gln Glu  Leu Gly Lys Ile Leu  Gln Gly Val 
    1925                 1930                 1935             


Val Val  Val Leu Ser Gly Phe  Gln Asn Pro Phe Arg  Ser Glu Leu 
    1940                 1945                 1950             


Arg Asp  Lys Ala Leu Glu Leu  Gly Ala Lys Tyr Arg  Pro Asp Trp 
    1955                 1960                 1965             


Thr Pro  Asp Ser Thr His Leu  Ile Cys Ala Phe Ala  Asn Thr Pro 
    1970                 1975                 1980             


Lys Tyr  Ser Gln Val Leu Gly  Leu Gly Gly Arg Ile  Val Arg Lys 
    1985                 1990                 1995             


Glu Trp  Val Leu Asp Cys Tyr  Arg Met Arg Arg Arg  Leu Pro Ser 
    2000                 2005                 2010             


Arg Arg  Tyr Leu Met Ala Gly  Leu Gly Ser Ser Ser  Glu Asp Glu 
    2015                 2020                 2025             


Gly Asp  Ser His Ser Glu Ser  Gly Glu Asp Glu Ala  Pro Lys Leu 
    2030                 2035                 2040             


Pro Arg  Lys Arg Pro Gln Pro  Lys Ala Lys Thr Gln  Ala Ala Gly 
    2045                 2050                 2055             


Pro Ser  Ser Pro Pro Arg Pro  Pro Thr Pro Glu Glu  Thr Lys Ala 
    2060                 2065                 2070             


Pro Ser  Pro Gly Pro Gln Asp  Asn Ser Asp Thr Asp  Gly Glu Gln 
    2075                 2080                 2085             


Ser Glu  Gly Arg Asp Asn Gly  Ala Glu Asp Ser Gly  Asp Thr Glu 
    2090                 2095                 2100             


Asp Glu  Leu Arg Arg Val Ala  Lys Gln Arg Glu Gln  Arg Gln Pro 
    2105                 2110                 2115             


Pro Ala  Pro Glu Glu Asn Gly  Glu Asp Pro Tyr Ala  Gly Ser Thr 
    2120                 2125                 2130             


Asp Glu  Asn Thr Asp Ser Glu  Ala Pro Ser Glu Ala  Asp Leu Pro 
    2135                 2140                 2145             


Ile Pro  Glu Leu Pro Asp Phe  Phe Gln Gly Lys His  Phe Phe Leu 
    2150                 2155                 2160             


Tyr Gly  Glu Phe Pro Gly Asp  Glu Arg Arg Lys Leu  Ile Arg Tyr 
    2165                 2170                 2175             


Val Thr  Ala Phe Asn Gly Glu  Leu Glu Asp Tyr Met  Ser Asp Arg 
    2180                 2185                 2190             


Val Gln  Phe Val Ile Thr Ala  Gln Glu Trp Asp Pro  Asn Phe Glu 
    2195                 2200                 2205             


Glu Ala  Leu Met Glu Asn Pro  Ser Leu Ala Phe Val  Arg Pro Arg 
    2210                 2215                 2220             


Trp Ile  Tyr Ser Cys Asn Glu  Lys Gln Lys Leu Leu  Pro His Gln 
    2225                 2230                 2235             


Leu Tyr  Gly Val Val Pro Gln  Ala Ser Gly Gly Ser  Pro Lys Lys 
    2240                 2245                 2250             


Lys Arg  Lys Val 
    2255         


<210>  71
<211>  2257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXC, rXRCC1


<220>
<221>  MISC_FEATURE
<222>  (1)..(229)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (234)..(863)
<223>  rXRCC1

<220>
<221>  MISC_FEATURE
<222>  (880)..(2246)
<223>  nCas9

<400>  71

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Ser Gly Gly Ser Pro Glu Ile Ser Leu Arg His 
225                 230                 235                 240 


Val Val Ser Cys Ser Ser Gln Asp Ser Thr His Arg Ala Glu Asn Leu 
                245                 250                 255     


Leu Lys Ala Asp Thr Tyr Arg Lys Trp Arg Ser Ala Lys Ala Gly Glu 
            260                 265                 270         


Lys Thr Ile Ser Val Val Leu Gln Leu Glu Lys Glu Glu Gln Ile His 
        275                 280                 285             


Ser Val Asp Ile Gly Asn Asp Gly Ser Ala Phe Val Glu Val Leu Val 
    290                 295                 300                 


Gly Ser Ser Ala Gly Gly Ala Thr Ala Gly Glu Gln Asp Tyr Glu Val 
305                 310                 315                 320 


Leu Leu Val Thr Ser Ser Phe Met Ser Pro Ser Glu Ser Arg Ser Gly 
                325                 330                 335     


Ser Asn Pro Asn Arg Val Arg Ile Phe Gly Pro Asp Lys Leu Val Arg 
            340                 345                 350         


Ala Ala Ala Glu Lys Arg Trp Asp Arg Val Lys Ile Val Cys Ser Gln 
        355                 360                 365             


Pro Tyr Ser Lys Asp Ser Pro Tyr Gly Leu Ser Phe Val Lys Phe His 
    370                 375                 380                 


Ser Pro Pro Asp Lys Asp Glu Ala Glu Ala Pro Ser Gln Lys Val Thr 
385                 390                 395                 400 


Val Thr Lys Leu Gly Gln Phe Arg Val Lys Glu Glu Asp Asp Ser Ala 
                405                 410                 415     


Asn Ser Leu Arg Pro Gly Ala Leu Phe Phe Asn Arg Ile Asn Lys Ala 
            420                 425                 430         


Ala Ser Ala Ser Ala Ser Asp Pro Ala Gly Pro Ser Tyr Ala Ala Ala 
        435                 440                 445             


Thr Leu Gln Ala Ser Ser Ala Ala Ser Ser Ala Leu Pro Val Pro Lys 
    450                 455                 460                 


Val Gly Gly Ser Ser Ser Lys Leu Gln Glu Pro Pro Lys Gly Lys Arg 
465                 470                 475                 480 


Lys Leu Asp Leu Gly Leu Glu Asp Ser Lys Pro Pro Ser Lys Pro Ser 
                485                 490                 495     


Ala Gly Pro Ala Ala Leu Lys Arg Pro Lys Leu Pro Val Pro Ser Arg 
            500                 505                 510         


Thr Pro Ala Ala Thr Pro Ala Ser Thr Pro Ala Gln Lys Ala Val Pro 
        515                 520                 525             


Gly Lys Pro Arg Gly Glu Gly Thr Glu Pro Arg Gly Ala Arg Ala Gly 
    530                 535                 540                 


Pro Gln Glu Leu Gly Lys Ile Leu Gln Gly Val Val Val Val Leu Ser 
545                 550                 555                 560 


Gly Phe Gln Asn Pro Phe Arg Ser Glu Leu Arg Asp Lys Ala Leu Glu 
                565                 570                 575     


Leu Gly Ala Lys Tyr Arg Pro Asp Trp Thr Pro Asp Ser Thr His Leu 
            580                 585                 590         


Ile Cys Ala Phe Ala Asn Thr Pro Lys Tyr Ser Gln Val Leu Gly Leu 
        595                 600                 605             


Gly Gly Arg Ile Val Arg Lys Glu Trp Val Leu Asp Cys Tyr Arg Met 
    610                 615                 620                 


Arg Arg Arg Leu Pro Ser Arg Arg Tyr Leu Met Ala Gly Leu Gly Ser 
625                 630                 635                 640 


Ser Ser Glu Asp Glu Gly Asp Ser His Ser Glu Ser Gly Glu Asp Glu 
                645                 650                 655     


Ala Pro Lys Leu Pro Arg Lys Arg Pro Gln Pro Lys Ala Lys Thr Gln 
            660                 665                 670         


Ala Ala Gly Pro Ser Ser Pro Pro Arg Pro Pro Thr Pro Glu Glu Thr 
        675                 680                 685             


Lys Ala Pro Ser Pro Gly Pro Gln Asp Asn Ser Asp Thr Asp Gly Glu 
    690                 695                 700                 


Gln Ser Glu Gly Arg Asp Asn Gly Ala Glu Asp Ser Gly Asp Thr Glu 
705                 710                 715                 720 


Asp Glu Leu Arg Arg Val Ala Lys Gln Arg Glu Gln Arg Gln Pro Pro 
                725                 730                 735     


Ala Pro Glu Glu Asn Gly Glu Asp Pro Tyr Ala Gly Ser Thr Asp Glu 
            740                 745                 750         


Asn Thr Asp Ser Glu Ala Pro Ser Glu Ala Asp Leu Pro Ile Pro Glu 
        755                 760                 765             


Leu Pro Asp Phe Phe Gln Gly Lys His Phe Phe Leu Tyr Gly Glu Phe 
    770                 775                 780                 


Pro Gly Asp Glu Arg Arg Lys Leu Ile Arg Tyr Val Thr Ala Phe Asn 
785                 790                 795                 800 


Gly Glu Leu Glu Asp Tyr Met Ser Asp Arg Val Gln Phe Val Ile Thr 
                805                 810                 815     


Ala Gln Glu Trp Asp Pro Asn Phe Glu Glu Ala Leu Met Glu Asn Pro 
            820                 825                 830         


Ser Leu Ala Phe Val Arg Pro Arg Trp Ile Tyr Ser Cys Asn Glu Lys 
        835                 840                 845             


Gln Lys Leu Leu Pro His Gln Leu Tyr Gly Val Val Pro Gln Ala Ser 
    850                 855                 860                 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Asp 
865                 870                 875                 880 


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                885                 890                 895     


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            900                 905                 910         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        915                 920                 925             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    930                 935                 940                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
945                 950                 955                 960 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                965                 970                 975     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            980                 985                 990         


Arg His Pro Ile Phe Gly Asn Ile  Val Asp Glu Val Ala  Tyr His Glu 
        995                 1000                 1005             


Lys Tyr  Pro Thr Ile Tyr His  Leu Arg Lys Lys Leu  Val Asp Ser 
    1010                 1015                 1020             


Thr Asp  Lys Ala Asp Leu Arg  Leu Ile Tyr Leu Ala  Leu Ala His 
    1025                 1030                 1035             


Met Ile  Lys Phe Arg Gly His  Phe Leu Ile Glu Gly  Asp Leu Asn 
    1040                 1045                 1050             


Pro Asp  Asn Ser Asp Val Asp  Lys Leu Phe Ile Gln  Leu Val Gln 
    1055                 1060                 1065             


Thr Tyr  Asn Gln Leu Phe Glu  Glu Asn Pro Ile Asn  Ala Ser Gly 
    1070                 1075                 1080             


Val Asp  Ala Lys Ala Ile Leu  Ser Ala Arg Leu Ser  Lys Ser Arg 
    1085                 1090                 1095             


Arg Leu  Glu Asn Leu Ile Ala  Gln Leu Pro Gly Glu  Lys Lys Asn 
    1100                 1105                 1110             


Gly Leu  Phe Gly Asn Leu Ile  Ala Leu Ser Leu Gly  Leu Thr Pro 
    1115                 1120                 1125             


Asn Phe  Lys Ser Asn Phe Asp  Leu Ala Glu Asp Ala  Lys Leu Gln 
    1130                 1135                 1140             


Leu Ser  Lys Asp Thr Tyr Asp  Asp Asp Leu Asp Asn  Leu Leu Ala 
    1145                 1150                 1155             


Gln Ile  Gly Asp Gln Tyr Ala  Asp Leu Phe Leu Ala  Ala Lys Asn 
    1160                 1165                 1170             


Leu Ser  Asp Ala Ile Leu Leu  Ser Asp Ile Leu Arg  Val Asn Thr 
    1175                 1180                 1185             


Glu Ile  Thr Lys Ala Pro Leu  Ser Ala Ser Met Ile  Lys Arg Tyr 
    1190                 1195                 1200             


Asp Glu  His His Gln Asp Leu  Thr Leu Leu Lys Ala  Leu Val Arg 
    1205                 1210                 1215             


Gln Gln  Leu Pro Glu Lys Tyr  Lys Glu Ile Phe Phe  Asp Gln Ser 
    1220                 1225                 1230             


Lys Asn  Gly Tyr Ala Gly Tyr  Ile Asp Gly Gly Ala  Ser Gln Glu 
    1235                 1240                 1245             


Glu Phe  Tyr Lys Phe Ile Lys  Pro Ile Leu Glu Lys  Met Asp Gly 
    1250                 1255                 1260             


Thr Glu  Glu Leu Leu Val Lys  Leu Asn Arg Glu Asp  Leu Leu Arg 
    1265                 1270                 1275             


Lys Gln  Arg Thr Phe Asp Asn  Gly Ser Ile Pro His  Gln Ile His 
    1280                 1285                 1290             


Leu Gly  Glu Leu His Ala Ile  Leu Arg Arg Gln Glu  Asp Phe Tyr 
    1295                 1300                 1305             


Pro Phe  Leu Lys Asp Asn Arg  Glu Lys Ile Glu Lys  Ile Leu Thr 
    1310                 1315                 1320             


Phe Arg  Ile Pro Tyr Tyr Val  Gly Pro Leu Ala Arg  Gly Asn Ser 
    1325                 1330                 1335             


Arg Phe  Ala Trp Met Thr Arg  Lys Ser Glu Glu Thr  Ile Thr Pro 
    1340                 1345                 1350             


Trp Asn  Phe Glu Glu Val Val  Asp Lys Gly Ala Ser  Ala Gln Ser 
    1355                 1360                 1365             


Phe Ile  Glu Arg Met Thr Asn  Phe Asp Lys Asn Leu  Pro Asn Glu 
    1370                 1375                 1380             


Lys Val  Leu Pro Lys His Ser  Leu Leu Tyr Glu Tyr  Phe Thr Val 
    1385                 1390                 1395             


Tyr Asn  Glu Leu Thr Lys Val  Lys Tyr Val Thr Glu  Gly Met Arg 
    1400                 1405                 1410             


Lys Pro  Ala Phe Leu Ser Gly  Glu Gln Lys Lys Ala  Ile Val Asp 
    1415                 1420                 1425             


Leu Leu  Phe Lys Thr Asn Arg  Lys Val Thr Val Lys  Gln Leu Lys 
    1430                 1435                 1440             


Glu Asp  Tyr Phe Lys Lys Ile  Glu Cys Phe Asp Ser  Val Glu Ile 
    1445                 1450                 1455             


Ser Gly  Val Glu Asp Arg Phe  Asn Ala Ser Leu Gly  Thr Tyr His 
    1460                 1465                 1470             


Asp Leu  Leu Lys Ile Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu 
    1475                 1480                 1485             


Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu 
    1490                 1495                 1500             


Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala 
    1505                 1510                 1515             


His Leu  Phe Asp Asp Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg 
    1520                 1525                 1530             


Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile 
    1535                 1540                 1545             


Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser 
    1550                 1555                 1560             


Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln Leu Ile  His Asp Asp 
    1565                 1570                 1575             


Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly 
    1580                 1585                 1590             


Gln Gly  Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
    1595                 1600                 1605             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1610                 1615                 1620             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1625                 1630                 1635             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1640                 1645                 1650             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1655                 1660                 1665             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1670                 1675                 1680             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1685                 1690                 1695             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1700                 1705                 1710             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1715                 1720                 1725             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1730                 1735                 1740             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1745                 1750                 1755             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1760                 1765                 1770             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1775                 1780                 1785             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1790                 1795                 1800             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1805                 1810                 1815             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1820                 1825                 1830             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1835                 1840                 1845             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1850                 1855                 1860             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1865                 1870                 1875             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1880                 1885                 1890             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1895                 1900                 1905             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1910                 1915                 1920             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1925                 1930                 1935             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1940                 1945                 1950             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1955                 1960                 1965             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1970                 1975                 1980             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1985                 1990                 1995             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    2000                 2005                 2010             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    2015                 2020                 2025             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    2030                 2035                 2040             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    2045                 2050                 2055             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    2060                 2065                 2070             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    2075                 2080                 2085             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    2090                 2095                 2100             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    2105                 2110                 2115             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    2120                 2125                 2130             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    2135                 2140                 2145             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    2150                 2155                 2160             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    2165                 2170                 2175             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    2180                 2185                 2190             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    2195                 2200                 2205             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    2210                 2215                 2220             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    2225                 2230                 2235             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Pro Lys Lys 
    2240                 2245                 2250             


Lys Arg  Lys Val 
    2255         


<210>  72
<211>  2257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XAC, rXRCC1


<220>
<221>  MISC_FEATURE
<222>  (1)..(631)
<223>  rXRCC1

<220>
<221>  MISC_FEATURE
<222>  (636)..(863)
<223>  APOBEC

<220>
<221>  MISC_FEATURE
<222>  (880)..(2246)
<223>  nCas9

<400>  72

Met Pro Glu Ile Ser Leu Arg His Val Val Ser Cys Ser Ser Gln Asp 
1               5                   10                  15      


Ser Thr His Arg Ala Glu Asn Leu Leu Lys Ala Asp Thr Tyr Arg Lys 
            20                  25                  30          


Trp Arg Ser Ala Lys Ala Gly Glu Lys Thr Ile Ser Val Val Leu Gln 
        35                  40                  45              


Leu Glu Lys Glu Glu Gln Ile His Ser Val Asp Ile Gly Asn Asp Gly 
    50                  55                  60                  


Ser Ala Phe Val Glu Val Leu Val Gly Ser Ser Ala Gly Gly Ala Thr 
65                  70                  75                  80  


Ala Gly Glu Gln Asp Tyr Glu Val Leu Leu Val Thr Ser Ser Phe Met 
                85                  90                  95      


Ser Pro Ser Glu Ser Arg Ser Gly Ser Asn Pro Asn Arg Val Arg Ile 
            100                 105                 110         


Phe Gly Pro Asp Lys Leu Val Arg Ala Ala Ala Glu Lys Arg Trp Asp 
        115                 120                 125             


Arg Val Lys Ile Val Cys Ser Gln Pro Tyr Ser Lys Asp Ser Pro Tyr 
    130                 135                 140                 


Gly Leu Ser Phe Val Lys Phe His Ser Pro Pro Asp Lys Asp Glu Ala 
145                 150                 155                 160 


Glu Ala Pro Ser Gln Lys Val Thr Val Thr Lys Leu Gly Gln Phe Arg 
                165                 170                 175     


Val Lys Glu Glu Asp Asp Ser Ala Asn Ser Leu Arg Pro Gly Ala Leu 
            180                 185                 190         


Phe Phe Asn Arg Ile Asn Lys Ala Ala Ser Ala Ser Ala Ser Asp Pro 
        195                 200                 205             


Ala Gly Pro Ser Tyr Ala Ala Ala Thr Leu Gln Ala Ser Ser Ala Ala 
    210                 215                 220                 


Ser Ser Ala Leu Pro Val Pro Lys Val Gly Gly Ser Ser Ser Lys Leu 
225                 230                 235                 240 


Gln Glu Pro Pro Lys Gly Lys Arg Lys Leu Asp Leu Gly Leu Glu Asp 
                245                 250                 255     


Ser Lys Pro Pro Ser Lys Pro Ser Ala Gly Pro Ala Ala Leu Lys Arg 
            260                 265                 270         


Pro Lys Leu Pro Val Pro Ser Arg Thr Pro Ala Ala Thr Pro Ala Ser 
        275                 280                 285             


Thr Pro Ala Gln Lys Ala Val Pro Gly Lys Pro Arg Gly Glu Gly Thr 
    290                 295                 300                 


Glu Pro Arg Gly Ala Arg Ala Gly Pro Gln Glu Leu Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gly Val Val Val Val Leu Ser Gly Phe Gln Asn Pro Phe Arg Ser 
                325                 330                 335     


Glu Leu Arg Asp Lys Ala Leu Glu Leu Gly Ala Lys Tyr Arg Pro Asp 
            340                 345                 350         


Trp Thr Pro Asp Ser Thr His Leu Ile Cys Ala Phe Ala Asn Thr Pro 
        355                 360                 365             


Lys Tyr Ser Gln Val Leu Gly Leu Gly Gly Arg Ile Val Arg Lys Glu 
    370                 375                 380                 


Trp Val Leu Asp Cys Tyr Arg Met Arg Arg Arg Leu Pro Ser Arg Arg 
385                 390                 395                 400 


Tyr Leu Met Ala Gly Leu Gly Ser Ser Ser Glu Asp Glu Gly Asp Ser 
                405                 410                 415     


His Ser Glu Ser Gly Glu Asp Glu Ala Pro Lys Leu Pro Arg Lys Arg 
            420                 425                 430         


Pro Gln Pro Lys Ala Lys Thr Gln Ala Ala Gly Pro Ser Ser Pro Pro 
        435                 440                 445             


Arg Pro Pro Thr Pro Glu Glu Thr Lys Ala Pro Ser Pro Gly Pro Gln 
    450                 455                 460                 


Asp Asn Ser Asp Thr Asp Gly Glu Gln Ser Glu Gly Arg Asp Asn Gly 
465                 470                 475                 480 


Ala Glu Asp Ser Gly Asp Thr Glu Asp Glu Leu Arg Arg Val Ala Lys 
                485                 490                 495     


Gln Arg Glu Gln Arg Gln Pro Pro Ala Pro Glu Glu Asn Gly Glu Asp 
            500                 505                 510         


Pro Tyr Ala Gly Ser Thr Asp Glu Asn Thr Asp Ser Glu Ala Pro Ser 
        515                 520                 525             


Glu Ala Asp Leu Pro Ile Pro Glu Leu Pro Asp Phe Phe Gln Gly Lys 
    530                 535                 540                 


His Phe Phe Leu Tyr Gly Glu Phe Pro Gly Asp Glu Arg Arg Lys Leu 
545                 550                 555                 560 


Ile Arg Tyr Val Thr Ala Phe Asn Gly Glu Leu Glu Asp Tyr Met Ser 
                565                 570                 575     


Asp Arg Val Gln Phe Val Ile Thr Ala Gln Glu Trp Asp Pro Asn Phe 
            580                 585                 590         


Glu Glu Ala Leu Met Glu Asn Pro Ser Leu Ala Phe Val Arg Pro Arg 
        595                 600                 605             


Trp Ile Tyr Ser Cys Asn Glu Lys Gln Lys Leu Leu Pro His Gln Leu 
    610                 615                 620                 


Tyr Gly Val Val Pro Gln Ala Ser Gly Gly Ser Ser Ser Glu Thr Gly 
625                 630                 635                 640 


Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu 
                645                 650                 655     


Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu 
            660                 665                 670         


Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr 
        675                 680                 685             


Ser Gln Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe 
    690                 695                 700                 


Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp 
705                 710                 715                 720 


Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu 
                725                 730                 735     


Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg 
            740                 745                 750         


Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu 
        755                 760                 765             


Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly 
    770                 775                 780                 


Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His 
785                 790                 795                 800 


Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu 
                805                 810                 815     


Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg 
            820                 825                 830         


Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His 
        835                 840                 845             


Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser 
    850                 855                 860                 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Asp 
865                 870                 875                 880 


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                885                 890                 895     


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            900                 905                 910         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        915                 920                 925             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    930                 935                 940                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
945                 950                 955                 960 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                965                 970                 975     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            980                 985                 990         


Arg His Pro Ile Phe Gly Asn Ile  Val Asp Glu Val Ala  Tyr His Glu 
        995                 1000                 1005             


Lys Tyr  Pro Thr Ile Tyr His  Leu Arg Lys Lys Leu  Val Asp Ser 
    1010                 1015                 1020             


Thr Asp  Lys Ala Asp Leu Arg  Leu Ile Tyr Leu Ala  Leu Ala His 
    1025                 1030                 1035             


Met Ile  Lys Phe Arg Gly His  Phe Leu Ile Glu Gly  Asp Leu Asn 
    1040                 1045                 1050             


Pro Asp  Asn Ser Asp Val Asp  Lys Leu Phe Ile Gln  Leu Val Gln 
    1055                 1060                 1065             


Thr Tyr  Asn Gln Leu Phe Glu  Glu Asn Pro Ile Asn  Ala Ser Gly 
    1070                 1075                 1080             


Val Asp  Ala Lys Ala Ile Leu  Ser Ala Arg Leu Ser  Lys Ser Arg 
    1085                 1090                 1095             


Arg Leu  Glu Asn Leu Ile Ala  Gln Leu Pro Gly Glu  Lys Lys Asn 
    1100                 1105                 1110             


Gly Leu  Phe Gly Asn Leu Ile  Ala Leu Ser Leu Gly  Leu Thr Pro 
    1115                 1120                 1125             


Asn Phe  Lys Ser Asn Phe Asp  Leu Ala Glu Asp Ala  Lys Leu Gln 
    1130                 1135                 1140             


Leu Ser  Lys Asp Thr Tyr Asp  Asp Asp Leu Asp Asn  Leu Leu Ala 
    1145                 1150                 1155             


Gln Ile  Gly Asp Gln Tyr Ala  Asp Leu Phe Leu Ala  Ala Lys Asn 
    1160                 1165                 1170             


Leu Ser  Asp Ala Ile Leu Leu  Ser Asp Ile Leu Arg  Val Asn Thr 
    1175                 1180                 1185             


Glu Ile  Thr Lys Ala Pro Leu  Ser Ala Ser Met Ile  Lys Arg Tyr 
    1190                 1195                 1200             


Asp Glu  His His Gln Asp Leu  Thr Leu Leu Lys Ala  Leu Val Arg 
    1205                 1210                 1215             


Gln Gln  Leu Pro Glu Lys Tyr  Lys Glu Ile Phe Phe  Asp Gln Ser 
    1220                 1225                 1230             


Lys Asn  Gly Tyr Ala Gly Tyr  Ile Asp Gly Gly Ala  Ser Gln Glu 
    1235                 1240                 1245             


Glu Phe  Tyr Lys Phe Ile Lys  Pro Ile Leu Glu Lys  Met Asp Gly 
    1250                 1255                 1260             


Thr Glu  Glu Leu Leu Val Lys  Leu Asn Arg Glu Asp  Leu Leu Arg 
    1265                 1270                 1275             


Lys Gln  Arg Thr Phe Asp Asn  Gly Ser Ile Pro His  Gln Ile His 
    1280                 1285                 1290             


Leu Gly  Glu Leu His Ala Ile  Leu Arg Arg Gln Glu  Asp Phe Tyr 
    1295                 1300                 1305             


Pro Phe  Leu Lys Asp Asn Arg  Glu Lys Ile Glu Lys  Ile Leu Thr 
    1310                 1315                 1320             


Phe Arg  Ile Pro Tyr Tyr Val  Gly Pro Leu Ala Arg  Gly Asn Ser 
    1325                 1330                 1335             


Arg Phe  Ala Trp Met Thr Arg  Lys Ser Glu Glu Thr  Ile Thr Pro 
    1340                 1345                 1350             


Trp Asn  Phe Glu Glu Val Val  Asp Lys Gly Ala Ser  Ala Gln Ser 
    1355                 1360                 1365             


Phe Ile  Glu Arg Met Thr Asn  Phe Asp Lys Asn Leu  Pro Asn Glu 
    1370                 1375                 1380             


Lys Val  Leu Pro Lys His Ser  Leu Leu Tyr Glu Tyr  Phe Thr Val 
    1385                 1390                 1395             


Tyr Asn  Glu Leu Thr Lys Val  Lys Tyr Val Thr Glu  Gly Met Arg 
    1400                 1405                 1410             


Lys Pro  Ala Phe Leu Ser Gly  Glu Gln Lys Lys Ala  Ile Val Asp 
    1415                 1420                 1425             


Leu Leu  Phe Lys Thr Asn Arg  Lys Val Thr Val Lys  Gln Leu Lys 
    1430                 1435                 1440             


Glu Asp  Tyr Phe Lys Lys Ile  Glu Cys Phe Asp Ser  Val Glu Ile 
    1445                 1450                 1455             


Ser Gly  Val Glu Asp Arg Phe  Asn Ala Ser Leu Gly  Thr Tyr His 
    1460                 1465                 1470             


Asp Leu  Leu Lys Ile Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu 
    1475                 1480                 1485             


Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu 
    1490                 1495                 1500             


Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala 
    1505                 1510                 1515             


His Leu  Phe Asp Asp Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg 
    1520                 1525                 1530             


Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile 
    1535                 1540                 1545             


Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser 
    1550                 1555                 1560             


Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln Leu Ile  His Asp Asp 
    1565                 1570                 1575             


Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly 
    1580                 1585                 1590             


Gln Gly  Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
    1595                 1600                 1605             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1610                 1615                 1620             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1625                 1630                 1635             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1640                 1645                 1650             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1655                 1660                 1665             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1670                 1675                 1680             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1685                 1690                 1695             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1700                 1705                 1710             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1715                 1720                 1725             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1730                 1735                 1740             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1745                 1750                 1755             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1760                 1765                 1770             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1775                 1780                 1785             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1790                 1795                 1800             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1805                 1810                 1815             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1820                 1825                 1830             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1835                 1840                 1845             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1850                 1855                 1860             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1865                 1870                 1875             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1880                 1885                 1890             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1895                 1900                 1905             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1910                 1915                 1920             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1925                 1930                 1935             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1940                 1945                 1950             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1955                 1960                 1965             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1970                 1975                 1980             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1985                 1990                 1995             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    2000                 2005                 2010             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    2015                 2020                 2025             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    2030                 2035                 2040             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    2045                 2050                 2055             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    2060                 2065                 2070             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    2075                 2080                 2085             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    2090                 2095                 2100             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    2105                 2110                 2115             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    2120                 2125                 2130             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    2135                 2140                 2145             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    2150                 2155                 2160             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    2165                 2170                 2175             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    2180                 2185                 2190             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    2195                 2200                 2205             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    2210                 2215                 2220             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    2225                 2230                 2235             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Pro Lys Lys 
    2240                 2245                 2250             


Lys Arg  Lys Val 
    2255         


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EMX1 target protospacer sequence


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Targeted C's

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  73
gagtccgagc agaagaagaa ggg                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FANCF target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  74
ggaatccctt ctgcagcacc tgg                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-1 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  75
gaacacaaag catagactgc ggg                                               23


<210>  76
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-2 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  76
gagcaccaca ccctaaacta tgg                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-3 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  77
ggaaacggat agttctgaaa ggg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-4 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  78
cttaactatt tgtattccac tgg                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-5 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  79
cttcccaagt gagaagccag tgg                                               23


<210>  80
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-6 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  80
ccagcccgct ggccctgtaa agg                                               23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-7 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  81
cattccgtta ttttacatat tgg                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-8 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  82
gtttccttta cagggccagc ggg                                               23


<210>  83
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-9 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  83
atacgcacag tttgacagat ggg                                               23


<210>  84
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-10 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  84
gctggccctg taaaggaaac tgg                                               23


<210>  85
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-11 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  85
gcatgcgtgt gtgtttaagc tgg                                               23


<210>  86
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-12 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  86
ttgggctgca gtaacttgaa ggg                                               23


<210>  87
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-13 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  87
tctttcaagc aggtgattac agg                                               23


<210>  88
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-14 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  88
agtttccttt acagggccag cgg                                               23


<210>  89
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-15 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  89
gaggtcgtgg ctgagcacaa ggg                                               23


<210>  90
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK2-16 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  90
ggcctctatt gttggtagaa tgg                                               23


<210>  91
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK3 target protospacer sequence


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Targeted C's

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  91
ggcccagact gagcacgtga tgg                                               23


<210>  92
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEK4 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  92
ggcactgcgg ctggaggtgg ggg                                               23


<210>  93
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNF2-1 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  93
gtcatcttag tcattacctg agg                                               23


<210>  94
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNF2-2 target protospacer sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  94
cacacacact tagaatctgt ggg                                               23


<210>  95
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNF2-3 target protospacer sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  95
acacacacac ttagaatctg tgg                                               23


<210>  96
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GJB2 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  96
ggacacgaag atcagctgca ggg                                               23


<210>  97
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADRB2 target protospacer sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  97
ccctttcctg cgtgacgtcg tgg                                               23


<210>  98
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYBPC3 target protospacer sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  98
ccctttcctg cgtgacgtcg tgg                                               23


<210>  99
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAL 292 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  99
gaagtcgttg tcaaacagga agg                                               23


<210>  100
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFA-1 target protospacer sequence


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Targeted C

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  PAMs

<400>  100
gatgtctgca ggccagatga ggg                                               23


<210>  101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  101

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  102
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  102

Ser Gly Gly Ser 
1               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  103

Ser Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  104
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  104

Gly Gly Gly Gly Ser 
1               5   


<210>  105
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  105

Glu Ala Ala Ala Lys 
1               5   


