                         SEQUENCE LISTING

<110>  Sotio a.s.
 
<120>  Tumor-specific Claudin 18.2 antibodies

<130>  S12411WO / SOTCLD-1904

<150>  19 219 359.7
<151>  2019-12-23

<150>  20 152 510.2
<151>  2020-01-17

<160>  133   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-1, cCl1-2, hCl1a, hCl1b, hCl1c, hCl1d, hCl1f, hCl1g HCDR1

<400>  1

Asp Tyr Ala Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-1, cCl1-3 HCDR2

<400>  2

Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-1, cCl1-3 , hCl1a, hCl1b, hCl1c, hCl1d, hCl1e, hCl1f, hCl1g 
       HCDR3

<400>  3

Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala 
1               5                   10  


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-1, hCl1a, hCl1b, hCl1e, hCl1f, hCl1h, hCl1i LCDR1

<400>  4

Arg Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-1, hCl1a, hCl1b, hCl1e, hCl1f, hCl1h, hCl1i LCDR2

<400>  5

Ser Val Lys Arg Leu Gln Asp 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-1, hCl1a, hCl1b, hCl1e, hCl1f, hCl1h, hCl1i LCDR3

<400>  6

Leu Gln Gly Ser Asn Phe Pro Leu Thr 
1               5                   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-2 HCDR2

<400>  7

Trp Ile Asn Ala Tyr Thr Gly Lys Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-2, hCl1h, hCl1i, hCl1j HCDR3

<400>  8

Ala Val Tyr Tyr Gly Tyr Thr Met Asp Ala 
1               5                   10  


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-2 LCDR1

<400>  9

Arg Thr Ser Glu Asp Ile Tyr Ser Asn Phe Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-2 LCDR2

<400>  10

Ser Val Asn Arg Leu Gln Asp 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-2, cCl1-3, hCl1c, hCl1d, hCl1g, hCl1j LCDR3

<400>  11

Leu Gln Gly Ser Lys Phe Pro Leu Thr 
1               5                   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-3, hCl1e, hCl1h, hCl1i, hCl1j HCDR1

<400>  12

Asp Tyr Ala Met Tyr 
1               5   


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-3 LCDR1

<400>  13

Arg Thr Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-3, hCl1c, hCl1j LCDR2

<400>  14

Ala Ile Lys Arg Leu Gln Asp 
1               5           


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1a, hCl1e HCDR2

<400>  15

Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1b, hCl1c, hCl1d HCDR2

<400>  16

Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1c, hCl1j LCDR1

<400>  17

Arg Thr Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1d, hCl1g LCDR1

<400>  18

Arg Thr Ser Glu Asp Ile Tyr Ser Asn Phe Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1d, hCl1g LCDR2

<400>  19

Ser Val Asn Arg Leu Gln Asp 
1               5           


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1g, hCl1h, hCl1i, hCl1j HCDR2

<400>  20

Trp Ile Asn Ala Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  H or Y

<400>  21

Asp Tyr Ala Met Xaa 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  A or S

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  D or Q

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  D or K

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  K or Q

<400>  22

Trp Ile Asn Xaa Tyr Thr Gly Lys Pro Thr Tyr Xaa Xaa Xaa Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  F or Y

<400>  23

Ala Val Xaa Tyr Gly Tyr Thr Met Asp Ala 
1               5                   10  


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  A or T

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  L or F

<400>  24

Arg Xaa Ser Glu Asp Ile Tyr Ser Asn Xaa Ala 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  V or I

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  K or N

<400>  25

Xaa Xaa Xaa Arg Leu Gln Asp 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  K or N

<400>  26

Leu Gln Gly Ser Xaa Phe Pro Leu Thr 
1               5                   


<210>  27
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-1 HC variable region

<400>  27

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Ala Ser Ala Ser Thr Ala Asn 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-1 LC variable region

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Ile Ser Ile Ala Cys Arg Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Phe Ser Val Lys Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Phe Cys Leu Gln Gly Ser Asn Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  29
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-2 HC variable region

<400>  29

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Gly Pro Gly Lys Gly Met Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Tyr Thr Gly Lys Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Leu Ser Leu Glu Ala Ser Ala Ser Thr Ala Asn 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Val Tyr Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Ile Val Ser Ser 
        115                 


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-2 LC variable region

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Ile Ser Ile Glu Cys Arg Thr Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Phe Ala Trp Phe Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ser Val Asn Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Phe Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-3 HC variable region

<400>  31

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Lys Gln Val Pro Gly Lys Gly Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Ala Ser Ala Ser Thr Ala Asn 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cCl1-3 LC variable region

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Ile Ser Ile Ala Cys Arg Thr Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Phe Ala Ile Lys Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Asp Tyr Phe Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1a HC variable region

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  34
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1b, hCl1c and hCl1d HC variable region

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1e HC variable region

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  36
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1f and hCl1g HC variable region

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1h, hCl1i and hCl1j HC variable region

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Tyr Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1a, hCl1b, hCl1e and hCl1i LC variable region

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ser Val Lys Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Asn Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1c and hCl1j LC variable region

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ile Lys Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1d and hCl1g LC variable region

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Val Asn Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1f and hCl1h LC variable region

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Val Lys Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Asn Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  42
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl3a, hCl1b and hCl1c HC variable region

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Arg Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Ile Ala Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Pro Ser Ile Thr Arg Ala Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  43
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl3a LC variable region

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Asn Ile Phe Lys Asn 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Ser Gly Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl3b LC variable region

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asn Ile Phe Lys Asn 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Ser Gly Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl3c LC variable region

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asn Ile Phe Lys Asn 
            20                  25                  30          


Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Asn Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Ser Gly Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  46
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1a HC full

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  47
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1b, hCl1c and hCl1d HC full

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  48
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1e HC full

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  49
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1f and hCl1g HC full

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Phe Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  50
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1h, hCl1i and hCl1j HC full

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Tyr Thr Gly Lys Pro Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Tyr Tyr Gly Tyr Thr Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  51
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1a, hCl1b, hCl1e and hCl1i LC full

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ser Val Lys Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Asn Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  52
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1c and hCl1j LC full

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ile Lys Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  53
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1d and hCl1g LC full

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Val Asn Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Lys Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  54
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCl1f and hCl1h LC full

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Val Lys Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gly Ser Asn Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  55
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMAB362 HC full

<400>  55

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  56
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IMAB362 LC full

<400>  56

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extracellular of CLDN18.2, independent of 
       glycosylation

<400>  57

Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn 
1               5                   10  


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extracellular of CLDN18.2, mainly unglycosylated

<400>  58

Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln 
1               5                   10      


<210>  59
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extracellular domain of CLDN18.2, unglycosylated

<400>  59

Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe 
1               5                   10                  


<210>  60
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pan-CLDN18 peptide in the C-terminal extracellular domain common 
       to both CLDN18.1 and CLDN18.2 isoforms

<400>  60

Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly 
1               5                   10              


<210>  61
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Specific epitope of CLDN18.2 as disclosed by WO2005/113587

<400>  61

Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
1               5                   10                  15      


<210>  62
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Specific epitope of CLDN18.2 as disclosed by WO2005/113587

<400>  62

Arg Ile Gly Ser Met Glu Asp Ser Ala Lys Ala Asn Met Thr Leu Thr 
1               5                   10                  15      


Ser Gly Ile Met Phe Ile Val Ser 
            20                  


<210>  63
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First extracellular domain of CLDN18.2 with N- and C-terminal 
       extensions

<400>  63

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Gly Thr Glu Leu Gly Ser Thr Pro Val Trp Trp Asn Ser Ala 
        35                  40                  45              


Asp Gly Arg Met Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn Asn Pro 
    50                  55                  60                  


Val Thr Ala Val Phe Asn Tyr Gln Gly Leu Trp Arg Ser Cys Val Arg 
65                  70                  75                  80  


Glu Ser Ser Gly Phe Thr Glu Cys Arg Gly Tyr Phe Thr Leu Leu Gly 
                85                  90                  95      


Leu Pro Ala Met Leu Gln Ala Val Arg Ala Ala Ile Gln His Ser Gly 
            100                 105                 110         


Gly Arg Ser Arg Arg Ala Arg Thr Lys Thr His Leu Arg Arg Gly Ser 
        115                 120                 125             


Glu 
    


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptide within the first extracellular domain as 
       disclosed by WO2008/145338

<400>  64

Met Asp Gln Trp Ser Thr Gln Asp Leu Tyr Asn Asn Pro Val Thr 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptide within the first extracellular domain as 
       disclosed by WO2008/145338

<400>  65

Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly Leu 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptide within the first extracellular domain as 
       disclosed by WO2008/145338

<400>  66

Val Phe Asn Tyr Gln Gly Leu Trp Arg Ser Cys Val Arg Glu Ser 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptide within the first extracellular domain as 
       disclosed by WO2008/145338

<400>  67

Gln Gly Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Overlapping peptide within the first extracellular domain as 
       disclosed by WO2008/145338

<400>  68

Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg Gly 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal epitope of CLDN18.2 as disclosed by WO2013/167259

<400>  69

Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser Lys His Asp Tyr Val 
1               5                   10                  15  


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal epitope of CLDN18.2 as disclosed by WO2013/167259

<400>  70

Glu Val Gln Ser Tyr Pro Ser Lys His Asp Tyr Val 
1               5                   10          


<210>  71
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1, cCl1-2, hCl1a HCDR1

<400>  71
gactacgcga tgcac                                                        15


<210>  72
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1 HCDR2

<400>  72
tggatcaaca cgtacacggg gaagccgaca tacgcggacg acttcaaggg g                51


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1, cCl1-3 HCDR3

<400>  73
gccgtcttct acggatatac gatggacgcg                                        30


<210>  74
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1 VH

<400>  74
cagatccagc tcgtccagag cgggccggag ctgaagaagc cgggggagag cgtgaagatc       60

tcgtgcaagg cgagcggata tacgttcacg gactacgcga tgcactgggt caagcaagcg      120

ccggggaaag ggctgaagtg gatggggtgg atcaacacgt acacggggaa gccgacatac      180

gcggacgact tcaaggggcg attcgtgttc tcgctggagg cgagcgcgag cacggcgaac      240

ctgcaaatct cgaacctgaa gaacgaggac acggcgacgt acttctgcgc gcgggccgtc      300

ttctacggat atacgatgga cgcgtggggg cagggtacca gcgtgacggt ctcgagc         357


<210>  75
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1 LCDR1

<400>  75
cgggcgagcg aggacatcta ctcgaacctg gcg                                    33


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1 LCDR2

<400>  76
tccgtcaagc ggctgcaaga c                                                 21


<210>  77
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1 LCDR3

<400>  77
ctgcaaggga gcaacttccc gctgacg                                           27


<210>  78
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1 VL

<400>  78
gacatccaga tgacgcagag cccggcgtcg ctgagcgcga gcctggggga gacgatctcg       60

atcgcgtgcc gggcgagcga ggacatctac tcgaacctgg cgtggtatca acagaagagc      120

gggaagagcc cgcagctgct gatcttctcc gtcaagcggc tgcaagacgg cgtcccgagc      180

cgattctcgg ggagcgggag cgggacgcag tactcgctga agatctcggg gatgcagccg      240

gaggacgagg gggactactt ctgcctgcaa gggagcaact tcccgctgac gttcgggtcg      300

ggtaccaaac tcgagatcaa a                                                321


<210>  79
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-2 HCDR2

<400>  79
tggatcaacg cgtacacggg gaagccgacc tacgcggacg acttcaaggg g                51


<210>  80
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-2 HCDR3

<400>  80
gccgtctact acggatatac gatggac                                           27


<210>  81
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-2 VH

<400>  81
cagatccagc tcgtccagag cgggccggag ctgaagaagc cgggggagag cgtgaagatc       60

tcgtgcaaga cgagcggata tacgttcacg gactacgcga tgcactgggt caagcagggg      120

ccagggaaag ggatgaagtg gatggggtgg atcaacgcgt acacggggaa gccgacctac      180

gcggacgact tcaaggggcg attcgtgctg agcctggagg cgagcgcctc gacggcgaac      240

ctgcaaatct cgaacctgaa gaacgaggac acggcgacgt acttctgcgc gcgggccgtc      300

tactacggat atacgatgga cgcgtggggg cagggtacca gcgtgatcgt ctcgagc         357


<210>  82
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-2 LCDR1

<400>  82
cggacgagcg aggacatcta ctcgaacttc gcg                                    33


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-2 LCDR2

<400>  83
tcagtcaacc ggctgcaaga c                                                 21


<210>  84
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-2, cCl1-3, hCl1d, hCl1g LCDR3

<400>  84
ctgcaaggga gcaagttccc gctgacg                                           27


<210>  85
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-1 VL

<400>  85
gacatccaga tgacgcagag cccggcgagc ctgagcgcga gcctggggga gacgatctcg       60

atcgagtgcc ggacgagcga ggacatctac tcgaacttcg cgtggttcca gcagaagagc      120

gggaagagcc cgcagctgct gatctactca gtcaaccggc tgcaagacgg cgtcccgagc      180

cgattctcgg ggagcgggag cgggacgcag tactcgctga agatctcggg gatgcagccg      240

gaggacgagg gggactactt ctgcctgcaa gggagcaagt tcccgctgac gttcgggagc      300

ggtaccaaac tcgagatcaa a                                                321


<210>  86
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-3 HCDR1

<400>  86
gactacgcga tgtac                                                        15


<210>  87
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-3 HCDR2

<400>  87
tggatcaaca cgtacacggg gaagccgacc tacgcggacg acttcaaggg g                51


<210>  88
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-3 VH

<400>  88
cagatccagc tcgtccagag cgggccggag ctgaagaagc cgggggagag cgtgaagatc       60

tcgtgcaagg cgagcggata tacgttcacg gactacgcga tgtactgggt caagcaagtg      120

ccggggaaag ggctgcgatg gatggggtgg atcaacacgt acacggggaa gccgacctac      180

gcggacgact tcaaggggcg attcgtgttc tcgctggagg cgagcgcgag cacggcgaac      240

ctgcaaatct cgaacctgaa gaacgaggac acggcgacgt acttctgcgc gcgggccgtc      300

ttctacggat atacgatgga cgcgtggggg cagggtacca gcgtgacggt ctcgagc         357


<210>  89
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-3 LCDR1

<400>  89
cggacgagcg aggacatcta ctcgaacctg gcg                                    33


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-3 LCDR2

<400>  90
gcgatcaagc ggctgcaaga c                                                 21


<210>  91
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1-3 VL

<400>  91
gacatccaga tgacgcagag cccggcgagc ctgagcgcga gcctggggga gacgatctcg       60

atcgcgtgcc ggacgagcga ggacatctac tcgaacctgg cgtggtatca acagaagagc      120

gggaagagcc cgcagctgct gatcttcgcg atcaagcggc tgcaagacgg cgtcccgagc      180

cgattctcgg ggagcgggag cgggacgcag tactcgctga agatctcggg gatgcagccg      240

gaggacgagg gggactactt ctgcctgcaa gggagcaagt tcccgctgac gttcgggtcg      300

ggtaccaaac tcgagatcaa a                                                321


<210>  92
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1a HCDR2

<400>  92
tggatcaata catacacggg gaagccgact tatgcgcaaa aattccaagg a                51


<210>  93
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1a HCDR3

<400>  93
gcggtcttct acggatatac gatggatgcc                                        30


<210>  94
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1a VH

<400>  94
caggtccaac tagtccaaag cggggcggaa gtcaagaagc ccggagcatc cgtcaaagtc       60

agctgcaagg cgagcggata tacatttacg gactacgcga tgcactgggt caggcaagcc      120

cctgggcaaa ggctcgaatg gatgggatgg atcaatacat acacggggaa gccgacttat      180

gcgcaaaaat tccaaggaag agtcacaatt acgcgggata catccgcatc taccgcctac      240

atggagctaa gctcgctgcg gagcgaggat acggcggtct actattgcgc ccgagcggtc      300

ttctacggat atacgatgga tgcctggggg cagggtaccc tggtcacggt ctcgagc         357


<210>  95
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1a, hCl1b, hCl1e, hCl1i LCDR1

<400>  95
agggcctccg aagacatcta ctccaacctg gca                                    33


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1a, hCl1b, hCl1e, hCl1i LCDR2

<400>  96
agcgtcaaaa gactacaaga t                                                 21


<210>  97
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1a, hCl1b, hCl1e, hCl1i LCDR3

<400>  97
ttgcaaggaa gcaatttccc cttgact                                           27


<210>  98
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cCl1a, hCl1b, hCl1e, hCl1i VL

<400>  98
gacattcaaa tgacgcaaag cccatcatcg ctgagcgcat cggtcgggga tagagtcacc       60

ataacatgca gggcctccga agacatctac tccaacctgg catggtatca acaaaaaccg      120

gggaaggctc cgaagctgct gatatttagc gtcaaaagac tacaagatgg agtaccgagc      180

cgattttcgg gaagcgggag cgggacggat ttcacgctga ccatatcaag tttgcaaccg      240

gaggattttg cgacatacta ttgcttgcaa ggaagcaatt tccccttgac tttcgggcaa      300

ggtaccaagg tcgagatcaa a                                                321


<210>  99
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1b, hCl1c, hCl1d HCDR1

<400>  99
gattatgcaa tgcac                                                        15


<210>  100
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1b, hCl1c, hCl1d HCDR2

<400>  100
tggattaaca cctacacggg caagcccaca tactcccaaa aattccaagg a                51


<210>  101
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1b, hCl1c, hCl1d HCDR3

<400>  101
gctgtattct atggatatac aatggatgcc                                        30


<210>  102
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1b, hCl1c, hCl1d VH

<400>  102
caggtccaat tagtccaaag cggggcggaa gtcaagaagc cgggggcgag cgtcaaagtc       60

tcatgcaaag cgagcggata cacatttacg gattatgcaa tgcactgggt caggcaagca      120

cccggacaaa ggctggaatg gatgggatgg attaacacct acacgggcaa gcccacatac      180

tcccaaaaat tccaaggaag ggtcacgata acgagagaca cgagcgcgag caccggaatg      240

gatgggatgg attaacacct acacgggcaa gcccacatac tcccaaaaat tccaaggaag      300

ggtcacgata acgagagaca cgagcgcgag caccgtaccc tggtcaccgt ctcgagc         357


<210>  103
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1c, hCl1j LCDR1

<400>  103
cgaacgagcg aggacatata ctcaaacctt gca                                    33


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1c, hCl1j LCDR2

<400>  104
gcgataaaga ggctgcaaga c                                                 21


<210>  105
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1c, hCl1j LCDR3

<400>  105
ttgcaaggct ccaaatttcc cctgaca                                           27


<210>  106
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1c, hCl1j VL

<400>  106
gacatccaaa tgactcaaag cccatcatcg ctatcggcat cggtcgggga tagagtcacg       60

ataacatgcc gaacgagcga ggacatatac tcaaaccttg catggtatca acaaaagccg      120

gggaaggccc cgaagctact gatattcgcg ataaagaggc tgcaagacgg agttccatca      180

cgattttcgg gatctggctc ggggaccgat tttacgctga ctatatcatc gctgcaaccg      240

gaagattttg caacatacta ctgcttgcaa ggctccaaat ttcccctgac attcggacaa      300

ggtaccaagg tcgagatcaa a                                                321


<210>  107
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1d, hCl1g LCDR1

<400>  107
cggacgagcg aggatattta ttcgaacttt gca                                    33


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1d, hCl1g LCDR2

<400>  108
cagtcaatcg gctacaagat                                                   20


<210>  109
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1d, hCl1g VL

<400>  109
gacatccaaa tgacgcaatc accgagctcg ctgagcgcat ctgtcgggga ccgtgtcaca       60

atcacatgcc ggacgagcga ggatatttat tcgaactttg catggtatca acaaaaaccg      120

ggcaaggctc cgaaactttt gatttattca gtcaatcggc tacaagatgg cgtcccgagc      180

cgatttagcg ggagcggatc gggaaccgac tttacgctga cgatatcatc gctacaaccg      240

gaggacttcg cgacttatta ctgcctacaa gggagcaaat tcccgctgac attcggacaa      300

ggtaccaagg tcgagatcaa a                                                321


<210>  110
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1e HCDR1

<400>  110
gattacgcaa tgtac                                                        15


<210>  111
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1e HCDR2

<400>  111
tggataaata cctatacggg aaagccaaca tacgcccaaa aattccaagg c                51


<210>  112
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1e HCDR3

<400>  112
gccgtctttt atggatatac gatggacgca                                        30


<210>  113
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1e VH

<400>  113
caggtccaac tggtccaatc gggggctgaa gtcaaaaagc cgggggcgag cgtcaaagtc       60

agctgcaaag catcgggata cacatttacg gattacgcaa tgtactgggt caggcaagca      120

cccggccaac gactggaatg gatgggctgg ataaatacct atacgggaaa gccaacatac      180

gcccaaaaat tccaaggccg cgtcacaata acgcgggaca cgagcgcatc gacggcttat      240

atggaactat catcgctgcg atcggaagac acggcggtct attattgcgc acgcgccgtc      300

ttttatggat atacgatgga cgcatggggg cagggtaccc tggtcacggt ctcgagc         357


<210>  114
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1g HCDR1

<400>  114
gactacgcaa tgcac                                                        15


<210>  115
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1g HCDR2

<400>  115
tggattaatg cctacacggg gaagccgacc tacgcacaaa aattccaagg a                51


<210>  116
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1g HCDR3

<400>  116
gccgtcttct atggatatac gatggatgct                                        30


<210>  117
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1g VH

<400>  117
caggtccaat tggtccaaag cggggcggag gtcaagaagc cgggggcgag cgtcaaagtc       60

tcatgcaagg caagcggata tacatttacg gactacgcaa tgcactgggt ccggcaagcc      120

cctgggcaac ggctggaatg gatgggatgg attaatgcct acacggggaa gccgacctac      180

gcacaaaaat tccaaggacg agtcacgatt acgcgggata ctagcgcgag caccgcatat      240

atggagctaa gctcgctgcg atctgaggat accgctgtat actactgcgc gagagccgtc      300

ttctatggat atacgatgga tgcttggggg cagggtaccc tggtcacggt ctcgagc         357


<210>  118
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1h LCDR1

<400>  118
cgagcttcgg aggacatcta tagcaacttg gct                                    33


<210>  119
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1h LCDR2

<400>  119
agcgtcaaaa ggctccaaga c                                                 21


<210>  120
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1h LCDR3

<400>  120
ctacaaggct ctaacttccc attgaca                                           27


<210>  121
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1f, hCl1h VL

<400>  121
gatatccaaa tgacgcaatc accatctagc ctatcggcct ctgtggggga ccgagtcacc       60

atcacatgcc gagcttcgga ggacatctat agcaacttgg cttggtatca acaaaagccg      120

gggaaagcac caaagctgct gatatatagc gtcaaaaggc tccaagacgg agtcccaagc      180

cgattctcgg gctccggctc cgggacggat tttacgctga caatttcgag cctgcaaccg      240

gaggactttg caacctacta ttgcctacaa ggctctaact tcccattgac atttgggcaa      300

ggtaccaagg tcgagatcaa a                                                321


<210>  122
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1h, hCl1i, hCl1j HCDR1

<400>  122
gactacgcta tgtat                                                        15


<210>  123
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1h, hCl1i, hCl1j HCDR2

<400>  123
tggattaatg cctacaccgg gaagccgact tatgcgcaaa aatttcaagg a                51


<210>  124
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1h, hCl1i, hCl1j HCDR3

<400>  124
gcggtctact atggatatac gatggacgca                                        30


<210>  125
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hCl1h, hCl1i, hCl1j VH

<400>  125
caggtccaac tggttcaatc tggagcggaa gtcaagaagc ccggagcatc cgtcaaagtc       60

tcgtgcaagg catctggata cacattcacc gactacgcta tgtattgggt ccggcaagcc      120

cccggacaac ggctggaatg gatgggatgg attaatgcct acaccgggaa gccgacttat      180

gcgcaaaaat ttcaaggaag ggtcacgatt acgcgggaca cgagcgcctc aaccgcatac      240

atggagctat cgagcctgcg aagcgaggac accgcggtct actactgcgc gcgggcggtc      300

tactatggat atacgatgga cgcatggggg cagggtaccc tggtcacggt ctcgagc         357


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 for hCl1x only, not chimeric clones cCl1-1,2,3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  T or A

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  A or S

<400>  126

Trp Ile Asn Xaa Tyr Thr Gly Lys Pro Thr Tyr Xaa Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  constant light chain - CL domain

<400>  127

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  128
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  constant heavy chain - CH1 + Fc domain

<400>  128

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  129
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L234A/L235A mutation in constant heavy chain - CH1 + Fc domain

<400>  129

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  130
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L236A/L236A/P329G mutation in constant heavy chain - CH1 + Fc 
       domain

<400>  130

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase tag

<400>  131

Arg Leu Pro Gln Thr Gly Gly 
1               5           


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase tag

<400>  132

Gly Gly Gly Gly Ser Leu Pro Gln Thr Gly Gly 
1               5                   10      


<210>  133
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 
1               5                   10                  15      


Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


