                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  PHARMACEUTICAL COMBINATION OF ANTIVIRAL AGENTS TARGETING HBV AND/OR AN IMMUNE MODULATOR FOR TREATMENT OF HBV

<130>  P119810PCT3

<150>  PCT/CN2020/130471
<151>  2020-11-20

<150>  PCT/CN2020/107002
<151>  2020-08-05

<150>  PCT/CN2019/127972
<151>  2019-12-24

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  3182
<212>  DNA
<213>  Hepatitis B virus

<400>  1
aattccacaa cctttcacca aactctgcaa gatcccagag tgagaggcct gtatttccct       60

gctggtggct ccagttcagg agcagtaaac cctgttccga ctactgcctc tcccttatcg      120

tcaatcttct cgaggattgg ggaccctgcg ctgaacatgg agaacatcac atcaggattc      180

ctaggacccc ttctcgtgtt acaggcgggg tttttcttgt tgacaagaat cctcacaata      240

ccgcagagtc tagactcgtg gtggacttct ctcaattttc tagggggaac taccgtgtgt      300

cttggccaaa attcgcagtc cccaacctcc aatcactcac caacctcctg tcctccaact      360

tgtcctggtt atcgctggat gtgtctgcgg cgttttatca tcttcctctt catcctgctg      420

ctatgcctca tcttcttgtt ggttcttctg gactatcaag gtatgttgcc cgtttgtcct      480

ctaattccag gatcctcaac caccagcacg ggaccatgcc gaacctgcat gactactgct      540

caaggaacct ctatgtatcc ctcctgttgc tgtaccaaac cttcggacgg aaattgcacc      600

tgtattccca tcccatcatc ctgggctttc ggaaaattcc tatgggagtg ggcctcagcc      660

cgtttctcct ggctcagttt actagtgcca tttgttcagt ggttcgtagg gctttccccc      720

actgtttggc tttcagttat atggatgatg tggtattggg ggccaagtct gtacagcatc      780

ttgagtccct ttttaccgct gttaccaatt ttcttttgtc tttgggtata catttaaacc      840

ctaacaaaac aaagagatgg ggttactctc tgaattttat gggttatgtc attggaagtt      900

atgggtcctt gccacaagaa cacatcatac aaaaaatcaa agaatgtttt agaaaacttc      960

ctattaacag gcctattgat tggaaagtat gtcaacgaat tgtgggtctt ttgggttttg     1020

ctgccccatt tacacaatgt ggttatcctg cgttaatgcc cttgtatgca tgtattcaat     1080

ctaagcaggc tttcactttc tcgccaactt acaaggcctt tctgtgtaaa caatacctga     1140

acctttaccc cgttgcccgg caacggccag gtctgtgcca agtgtttgct gacgcaaccc     1200

ccactggctg gggcttggtc atgggccatc agcgcgtgcg tggaaccttt tcggctcctc     1260

tgccgatcca tactgcggaa ctcctagccg cttgttttgc tcgcagcagg tctggagcaa     1320

acattatcgg gactgataac tctgttgtcc tctcccgcaa atatacatcg tatccatggc     1380

tgctaggctg tgctgccaac tggatcctgc gcgggacgtc ctttgtttac gtcccgtcgg     1440

cgctgaatcc tgcggacgac ccttctcggg gtcgcttggg actctctcgt ccccttctcc     1500

gtctgccgtt ccgaccgacc acggggcgca cctctcttta cgcggactcc ccgtctgtgc     1560

cttctcatct gccggaccgt gtgcacttcg cttcacctct gcacgtcgca tggagaccac     1620

cgtgaacgcc caccgaatgt tgcccaaggt cttacataag aggactcttg gactctctgc     1680

aatgtcaacg accgaccttg aggcatactt caaagactgt ttgtttaaag actgggagga     1740

gttgggggag gagattagat taaaggtctt tgtactagga ggctgtaggc ataaattggt     1800

ctgcgcacca gcaccatgca actttttcac ctctgcctaa tcatctcttg ttcatgtcct     1860

actgttcaag cctccaagct gtgccttggg tggctttggg gcatggacat cgacccttat     1920

aaagaatttg gagctactgt ggagttactc tcgtttttgc cttctgactt ctttccttca     1980

gtacgagatc ttctagatac cgcctcagct ctgtatcggg aagccttaga gtctcctgag     2040

cattgttcac ctcaccatac tgcactcagg caagcaattc tttgctgggg ggaactaatg     2100

actctagcta cctgggtggg tgttaatttg gaagatccag catctagaga cctagtagtc     2160

agttatgtca acactaatat gggcctaaag ttcaggcaac tcttgtggtt tcacatttct     2220

tgtctcactt ttggaagaga aaccgttata gagtatttgg tgtctttcgg agtgtggatt     2280

cgcactcctc cagcttatag accaccaaat gcccctatcc tatcaacact tccggaaact     2340

actgttgtta gacgacgagg caggtcccct agaagaagaa ctccctcgcc tcgcagacga     2400

aggtctcaat cgccgcgtcg cagaagatct caatctcggg aacctcaatg ttagtattcc     2460

ttggactcat aaggtgggga actttactgg tctttattct tctactgtac ctgtctttaa     2520

tcctcattgg aaaacaccat cttttcctaa tatacattta caccaagaca ttatcaaaaa     2580

atgtgaacag tttgtaggcc cacttacagt taatgagaaa agaagattgc aattgattat     2640

gcctgctagg ttttatccaa aggttaccaa atatttacca ttggataagg gtattaaacc     2700

ttattatcca gaacatctag ttaatcatta cttccaaact agacactatt tacacactct     2760

atggaaggcg ggtatattat ataagagaga aacaacacat agcgcctcat tttgtgggtc     2820

accatattct tgggaacaag atctacagca tggggcagaa tctttccacc agcaatcctc     2880

tgggattctt tcccgaccac cagttggatc cagccttcag agcaaacaca gcaaatccag     2940

attgggactt caatcccaac aaggacacct ggccagacgc caacaaggta ggagctggag     3000

cattcgggct gggtttcacc ccaccgcacg gaggcctttt ggggtggagc cctcaggctc     3060

agggcatact acaaactttg ccagcaaatc cgcctcctgc ctccaccaat cgccagacag     3120

gaaggcagcc taccccgctg tctccacctt tgagaaacac tcatcctcag gccatgcagt     3180

gg                                                                    3182


<210>  2
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  2
gcgtaaagag agg                                                          13


<210>  3
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  3
gcgtaaagag aggt                                                         14


<210>  4
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  4
cgcgtaaaga gaggt                                                        15


<210>  5
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  5
agaaggcaca gacgg                                                        15


<210>  6
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  6
gagaaggcac agacgg                                                       16


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  7
agcgaagtgc acacgg                                                       16


<210>  8
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  8
gaagtgcaca cgg                                                          13


<210>  9
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  9
gcgaagtgca cacgg                                                        15


<210>  10
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  10
agcgaagtgc acacg                                                        15


<210>  11
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  11
cgaagtgcac acg                                                          13


<210>  12
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  12
aggtgaagcg aagtgc                                                       16


<210>  13
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  13
aggtgaagcg aagtg                                                        15


<210>  14
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  contiguous nucleotide sequence

<400>  14
aggtgaagcg aagt                                                         14


<210>  15
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  15
cagcgtaaag agagg                                                        15


<210>  16
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  16
cagcgtaaag agaggt                                                       16


<210>  17
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  17
cacgcgtaaa gagaggt                                                      17


<210>  18
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  18
caagaaggca cagacgg                                                      17


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  19
cagagaaggc acagacgg                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  20
caagcgaagt gcacacgg                                                     18


<210>  21
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  21
cagaagtgca cacgg                                                        15


<210>  22
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  22
cagcgaagtg cacacgg                                                      17


<210>  23
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  23
caagcgaagt gcacacg                                                      17


<210>  24
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  24
cacgaagtgc acacg                                                        15


<210>  25
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  25
caaggtgaag cgaagtgc                                                     18


<210>  26
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  26
caaggtgaag cgaagtg                                                      17


<210>  27
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide sequence

<400>  27
caaggtgaag cgaagt                                                       16


<210>  28
<211>  69
<212>  DNA
<213>  Hepatitis B virus

<400>  28
cctctcttta cgcggactcc ccgtctgtgc cttctcatct gccggaccgt gtgcacttcg       60

cttcacctc                                                               69


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide motif

<400>  29
gcagaggtga agcgaagtgc                                                   20


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
ctgtgccttg ggtggcttt                                                    19


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
aaggaaagaa gtcagaaggc aaaa                                              24


<210>  32
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  32
agctccaaat tctttataag ggtcgatgtc catg                                   34


<210>  33
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or u

<400>  33
acaanaaucc ucacaaua                                                     18


<210>  34
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or u

<400>  34
uunuugugag gauun                                                        15


<210>  35
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or u

<400>  35
uuauugugag gauunuuguc                                                   20


<210>  36
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or u

<400>  36
uuauugugag gauunuuguc gg                                                22


<210>  37
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  37
uuauugugag gauucuuguc gg                                                22


<210>  38
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  38
uuauugugag gauuuuuguc gg                                                22


<210>  39
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or u

<400>  39
acaanaaucc ucacaauaa                                                    19


<210>  40
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or u

<400>  40
gacaanaauc cucacaauaa gcagccgaaa ggcugc                                 36


<210>  41
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  41
gacaaaaauc cucacaauaa gcagccgaaa ggcugc                                 36


<210>  42
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  42
gacaagaauc cucacaauaa gcagccgaaa ggcugc                                 36


<210>  43
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  43
aatcctcaca                                                              10


<210>  44
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  44
ugugaggauu                                                              10


<210>  45
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  45
tgtgaggatt                                                              10


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  46
tattgtgagg attcttgtca                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  47
cggtattgtg aggattcttg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  48
tgtgaggatt cttgtcaaca                                                   20


<210>  49
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  49
uauugugagg auuuuuguca a                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  50
ugcgguauug ugaggauuct t                                                 21


<210>  51
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  51
acagcattgt gaggattctt gtc                                               23


<210>  52
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  52
uauugugagg auuuuuguca aca                                               23


<210>  53
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  53
auugugagga uuuuugucaa caa                                               23


<210>  54
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  54
uugugaggau uuuugucaac aag                                               23


<210>  55
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  55
gugguggacu ucucucaaua gcagccgaaa ggcugc                                 36


<210>  56
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  56
uauugagaga aguccaccac gg                                                22


<210>  57
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  57
uuugugagga uuuuugucaa gg                                                22


<210>  58
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  58
ucugagagaa guccaccacg gg                                                22


<210>  59
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  59
uacugagaga aguccaccac gg                                                22


<210>  60
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  60
uaaaacugag agaaguccac gg                                                22


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  61
gacaagaatc ctcacaata                                                    19


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  62
cgtggtggac ttctctcaa                                                    19


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  63
gtggacttct ctcaatttt                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  64
gacaanaatc ctcacaata                                                    19


<210>  65
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<400>  65
cgtggtggac ttctctcan                                                    19


<210>  66
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  66
gtggacttct ctcantttt                                                    19


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  67
tgttgacaag aatcctcaca at                                                22


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  68
tcgtggtgga cttctctcaa t                                                 21


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<400>  69
tgttgacaan aatcctcaca at                                                22


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is a, c, g, or t

<400>  70
tcgtggtgga cttctctcan t                                                 21


<210>  71
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  71
ugcacuucgc gucaccucua gcagccgaaa ggcugc                                 36


<210>  72
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  72
uagaggugac gcgaagugca gg                                                22


<210>  73
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  73
gcaccucucu uuacgcggaa gcagccgaaa ggcugc                                 36


<210>  74
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  74
uuccgcguaa agagaggugc gg                                                22


<210>  75
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  may be modified by phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (18)..(26)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  may be modified by 2'-modified-GalNAc guanosine

<220>
<221>  misc_feature
<222>  (28)..(30)
<223>  may be modified by 2'-modified-GalNAc adenosine

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  may be modified by 2'-O-methyl ribonucleotide

<400>  75
gacaaaaauc cucacaauaa gcagccgaaa ggcugc                                 36


<210>  76
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  may be modified by 4'-O-monomethylphosphonate-2'-O-methyl uridine

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  may be modified by phosphorothioate

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  may be modified by 2'-fluoro-deoxyribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  may be modified by 2'-O-methyl ribonucleotide

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  may be modified by phosphorothioate

<400>  76
uuauugugag gauuuuuugu cgg                                               23


<210>  77
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  77
tgttgacaag aatcctcaca atacctcgtg gtggacttct ctcaattttc                  50


<210>  78
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  78
ggaacuguuu uuaggagugu uu                                                22


<210>  79
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  79
ggaacuguuc uuaggagugu uu                                                22


<210>  80
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  80
ggcuguuuuu aggaguguua uu                                                22


<210>  81
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  81
ggcuguucuu aggaguguua uu                                                22


<210>  82
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  82
ttgacaagaa tcctcacaat ac                                                22


<210>  83
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  83
gggcaccacc ugaagagagu cu                                                22


<210>  84
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  84
gggcaccacc ugaagagagu uu                                                22


<210>  85
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  85
ctcgtggtgg acttctctca at                                                22


<210>  86
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  86
ggcaccaccu gaagagaguc au                                                22


<210>  87
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  87
ggcaccaccu gaagagaguu au                                                22


<210>  88
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  88
tcgtggtgga cttctctcaa tt                                                22


<210>  89
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  89
ggcaccugaa gagagucaaa au                                                22


<210>  90
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  90
ggcaccugaa gagaguuaaa au                                                22


<210>  91
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  91
tggtggactt ctctcaattt tc                                                22


