SEQUENCE LISTING

<110> Cellectis

<120> NEW MESOTHELIN SPECIFIC CHIMERIC ANTIGEN RECEPTORS (CAR) 
FOR SOLID TUMORS CANCER IMMUNOTHERAPY

<130> P81905747PCT00

<150> PA201970835
<151> 2019-12-23

<160> 161

<170> PatentIn version 3.5

<210>  1

<211>  127
<212>  PRT
<213>  artificial

<220>
<223>  P4 heavy chain variable region

<400>  1
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly 
        115                 120                 125         


<210>  2

<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  P4 light chain variable region

<400>  2
Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu 
            100                 105                 110         


Thr Val Leu Ser 
        115     


<210>  3

<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDRH1- meso1

<400>  3
Ser Tyr Tyr Trp Ser 
1               5   


<210>  4

<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  CDRH2- meso1

<400>  4
Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      






<210>  5

<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  CDRH3- meso1

<400>  5
Val Asp Tyr Lys Ala Phe Asp Ile 
1               5               


<210>  6

<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDRL1- meso1

<400>  6
Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu His 
1               5                   10      


<210>  7

<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDRL2- meso1

<400>  7
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  8

<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDRL3- meso1

<400>  8
Leu Gln His Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  9

<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  meso1 heavy chain variable region

<400>  9
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Asp Tyr Lys Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10

<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  meso1 light chain variable region

<400>  10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Tyr Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11

<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  meso2 heavy chain variable region

<400>  11
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Met Pro Ser Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  12

<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  meso2 light chain variable region

<400>  12
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser His Asp Pro 
                85                  90                  95      


Ser Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110     


<210>  13

<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Linker

<400>  13
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14

<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  CD8&#945; signal peptide

<400>  14
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  15

<211>  40
<212>  PRT
<213>  artificial

<220>
<223>  R2 suicide switch

<400>  15
Ser Asp Pro Gly Ser Gly Gly Gly Gly Ser Cys Pro Tyr Ser Asn Pro 
1               5                   10                  15      


Ser Leu Cys Ser Gly Gly Gly Gly Ser Cys Pro Tyr Ser Asn Pro Ser 
            20                  25                  30          


Leu Cys Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  16

<211>  45
<212>  PRT
<213>  artificial

<220>
<223>  CD8&#945; hinge

<400>  16
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  17

<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  CD8&#945; transmembrane domain

<400>  17
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  18

<211>  42
<212>  PRT
<213>  artificial

<220>
<223>  4-1BB co-stimulatory domain

<400>  18
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  19

<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  CD3&#950; signalling domain

<400>  19
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         






<210>  20

<211>  542
<212>  PRT
<213>  artificial

<220>
<223>  P4-R2 CAR full sequence

<400>  20
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
65                  70                  75                  80  


Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ile Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser 
                165                 170                 175     


Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn 
            180                 185                 190         


Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro 
        195                 200                 205             


Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly 
    210                 215                 220                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn 
225                 230                 235                 240 


Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp 
                245                 250                 255     


Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly 
            260                 265                 270         


Thr Gln Leu Thr Val Leu Ser Ser Asp Pro Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Thr 
305                 310                 315                 320 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
                325                 330                 335     


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            340                 345                 350         


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
        355                 360                 365             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    370                 375                 380                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
385                 390                 395                 400 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                405                 410                 415     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            420                 425                 430         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        435                 440                 445             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    450                 455                 460                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
465                 470                 475                 480 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                485                 490                 495     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            500                 505                 510         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        515                 520                 525             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540         


<210>  21

<211>  522
<212>  PRT
<213>  artificial

<220>
<223>  meso1-R2 CAR full sequence

<400>  21
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Val Asp Tyr Lys Ala Phe Asp Ile Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
                165                 170                 175     


Ala Ser Gln Gly Ile Arg Asn Asp Leu His Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Leu Gln His Tyr Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Ser Asp Pro Gly Ser Gly Gly Gly Gly Ser Cys Pro Tyr 
            260                 265                 270         


Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Cys Pro Tyr Ser 
        275                 280                 285             


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Thr Thr Thr Pro Ala 
    290                 295                 300                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
305                 310                 315                 320 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                325                 330                 335     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            340                 345                 350         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        355                 360                 365             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    370                 375                 380                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                405                 410                 415     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            420                 425                 430         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        435                 440                 445             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    450                 455                 460                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
465                 470                 475                 480 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                485                 490                 495     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            500                 505                 510         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520         


<210>  22

<211>  482
<212>  PRT
<213>  artificial

<220>
<223>  meso1 CAR full sequence

<400>  22
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
        35                  40                  45              


Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Val Asp Tyr Lys Ala Phe Asp Ile Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
                165                 170                 175     


Ala Ser Gln Gly Ile Arg Asn Asp Leu His Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
        195                 200                 205             


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Leu Gln His Tyr Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  23

<211>  531
<212>  PRT
<213>  artificial

<220>
<223>  meso2-R2 full sequence

<400>  23
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Val Ile Met Pro Ser Asp Ser Tyr Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Tyr Gly His Gly Met Tyr Gly Gly Ala 
        115                 120                 125             


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                165                 170                 175     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser Arg Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly 
        195                 200                 205             


Ala Ser Lys Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser His Asp Pro Ser Gly Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Ser Asp Pro Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
305                 310                 315                 320 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
                325                 330                 335     


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
            340                 345                 350         


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
        355                 360                 365             


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
    370                 375                 380                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
385                 390                 395                 400 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                405                 410                 415     


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
465                 470                 475                 480 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                485                 490                 495     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            500                 505                 510         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        515                 520                 525             


Pro Pro Arg 
    530     


<210>  24

<211>  199
<212>  PRT
<213>  artificial

<220>
<223>  dominant negative dnTGF&#946;RII

<400>  24
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser 
        195                 


<210>  25

<211>  291
<212>  PRT
<213>  homo sapiens

<220>
<223>  MSLN target antigen region

<400>  25
Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile 
1               5                   10                  15      


Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val 
            20                  25                  30          


Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro 
        35                  40                  45              


Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu 
    50                  55                  60                  


Tyr Pro Gln Gly Tyr Pro Glu Ser Val Ile Gln His Leu Gly Tyr Leu 
65                  70                  75                  80  


Phe Leu Lys Met Ser Pro Glu Asp Ile Arg Lys Trp Asn Val Thr Ser 
                85                  90                  95      


Leu Glu Thr Leu Lys Ala Leu Leu Glu Val Asn Lys Gly His Glu Met 
            100                 105                 110         


Ser Pro Gln Ala Pro Arg Arg Pro Leu Pro Gln Val Ala Thr Leu Ile 
        115                 120                 125             


Asp Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp 
    130                 135                 140                 


Thr Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Glu Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln 
                165                 170                 175     


Asp Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys 
            180                 185                 190         


Ala Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys 
        195                 200                 205             


Ile Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu 
    210                 215                 220                 


Ser Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg 
225                 230                 235                 240 


Thr Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu 
                245                 250                 255     


Gly Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val 
            260                 265                 270         


Arg Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly 
        275                 280                 285             


Leu Gly Leu 
    290     


<210>  26

<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Mimotope R2 (Rituximab)

<400>  26
Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
1               5                   


<210>  27

<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  Palivizumab epitope

<400>  27
Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  28

<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Cetuximab epitope 1

<400>  28
Cys Gln Phe Asp Leu Ser Thr Arg Arg Leu Lys Cys 
1               5                   10          


<210>  29

<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Cetuximab epitope 2

<400>  29
Cys Gln Tyr Asn Leu Ser Ser Arg Ala Leu Lys Cys 
1               5                   10          


<210>  30

<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Cetuximab epitope 3

<400>  30
Cys Val Trp Gln Arg Trp Gln Lys Ser Tyr Val Cys 
1               5                   10          


<210>  31

<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Cetuximab epitope 4

<400>  31
Cys Met Trp Asp Arg Phe Ser Arg Trp Tyr Lys Cys 
1               5                   10          


<210>  32

<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  Nivolumab epitope 1

<400>  32
Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp 
1               5                   10                  15      


Lys Leu Ala Ala Phe Pro Glu Asp Arg 
            20                  25  


<210>  33

<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  Nivolumab epitope 2

<400>  33
Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln 
1               5                   10                  15      


Ile Lys Glu 
            


<210>  34

<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  QBEND-10 Epitope

<400>  34
Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


Pro Ala Lys Pro Thr Thr Thr Ala 
            20                  


<210>  35

<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Alemtuzumab epitope

<400>  35
Gly Gln Asn Asp Thr Ser Gln Thr Ser Ser Pro Ser 
1               5                   10          



<210>  36

<211>  49
<212>  DNA
<213>  homo sapiens

<220>
<223>  T003387 target sequence TGFbetaRII

<400>  36
ttttgtttcc ccatcagaat ataacaccag caatcctgac ttgttgcta                 49


<210>  37

<211>  49
<212>  DNA
<213>  homo sapiens

<220>
<223>  T003401 target sequence TGFbetaRII

<400>  37
tccctatgag gagtatgcct cttggaagac agagaaggac atcttctca                 49


<210>  38

<211>  49
<212>  DNA
<213>  homo sapiens

<220>
<223>  T003400 target sequence TGFbetaRII

<400>  38
tccctatgag gagtatgcct cttggaagac agagaaggac atcttctca                 49


<210>  39

<211>  49
<212>  DNA
<213>  homo sapiens

<220>
<223>  T003405 target sequence TGFbetaRII

<400>  39
tgtgggaggc ccaagatgcc catcgtgcac agggacctca agagctcca                 49


<210>  40

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  40
acagtgatca cactccatgt ggg                                             23


<210>  41

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  41
gcagaagctg agttcaacct ggg                                             23


<210>  42

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  42
aggttaggtc gttcttcacg agg                                             23


<210>  43

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  43
aaagcgacct ttccccacca ggg                                             23


<210>  44

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  44
tggatgacct ggctaacagt ggg                                             23


<210>  45

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  45
cctgggaaac cggcaagacg cgg                                             23


<210>  46

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  46
acagatatgg caactcccag tgg                                             23


<210>  47

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  47
gtggaggtga gcaatccccc ggg                                             23


<210>  48

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  48
acctacagga gtacctgacg cgg                                             23


<210>  49

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  49
gtgatcacac tccatgtggg agg                                             23


<210>  50

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  50
gctggtgtta tattctgatg ggg                                             23


<210>  51

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  51
cacagtgatc acactccatg tgg                                             23


<210>  52

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  52
cacatggagt gtgatcactg tgg                                             23


<210>  53

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  53
cagagtaggg tccagacgca ggg                                             23


<210>  54

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  54
gcttctgctg ccggttaacg cgg                                             23


<210>  55

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  55
gtggatgacc tggctaacag tgg                                             23


<210>  56

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  56
gggaaagccc aaagtcacac agg                                             23


<210>  57

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  57
aatatgacta gcaacaagtc agg                                             23


<210>  58

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  58
atggagtgtg atcactgtgg agg                                             23


<210>  59

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  59
atcaccgcct tccacgccaa ggg                                             23


<210>  60

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  60
aggagcggaa gacggagttg ggg                                             23


<210>  61

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  61
ccacgccaag ggcaacctac agg                                             23


<210>  62

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  62
caagatgccc atcgtgcaca ggg                                             23


<210>  63

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  63
gatatggcaa ctcccagtgg tgg                                             23


<210>  64

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  64
agcagaagct gagttcaacc tgg                                             23


<210>  65

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  65
cctgtaggtt gcccttggcg tgg                                             23


<210>  66

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  66
gtgagcaatc ccccgggcga ggg                                             23


<210>  67

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  67
acagagtagg gtccagacgc agg                                             23


<210>  68

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  68
tagcaacaag tcaggattgc tgg                                             23


<210>  69

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  69
ccaagatgcc catcgtgcac agg                                             23


<210>  70

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  70
tgtggaggtg agcaatcccc cgg                                             23


<210>  71

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  71
tgcctcttgg aagacagaga agg                                             23


<210>  72

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  72
gcccattgag ctggacaccc tgg                                             23


<210>  73

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  73
ctgagttcaa cctgggaaac cgg                                             23


<210>  74

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  74
tgggaggacc tgcgcaagct ggg                                             23


<210>  75

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  75
gtactcctgt aggttgccct tgg                                             23


<210>  76

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  76
tcttccgctc ctcagccgtc agg                                             23


<210>  77

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  77
ctgggcagct ccctcgcccg ggg                                             23


<210>  78

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  78
cattgagctg gacaccctgg tgg                                             23


<210>  79

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  79
tggcaactcc cagtggtggc agg                                             23


<210>  80

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  80
caactcccag tggtggcagg agg                                             23


<210>  81

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  81
cgagcactgt gccatcatcc tgg                                             23


<210>  82

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  82
gcggtcatct tccaggatga tgg                                             23


<210>  83

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  83
agagctgctg cccattgagc tgg                                             23


<210>  84

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  84
accagggtgt ccagctcaat ggg                                             23


<210>  85

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  85
ctggacaccc tggtggggaa agg                                             23


<210>  86

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  86
caaagcgacc tttccccacc agg                                             23


<210>  87

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  87
gacggctgag gagcggaaga cgg                                             23


<210>  88

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  88
tactctgtct gtggatgacc tgg                                             23


<210>  89

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  89
cggcaagacg cggaagctca tgg                                             23


<210>  90

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  90
cccaaagtca cacaggcagc agg                                             23


<210>  91

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  91
taggttgccc ttggcgtgga agg                                             23


<210>  92

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  92
tgaggagcgg aagacggagt tgg                                             23


<210>  93

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  93
cctgtgcacg atgggcatct tgg                                             23


<210>  94

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  94
gggagctgcc cagcttgcgc agg                                             23


<210>  95

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  95
ttgaactcag cttctgctgc cgg                                             23


<210>  96

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  96
ccaagaggca tactcctcat agg                                             23


<210>  97

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  97
catgagcttc cgcgtcttgc cgg                                             23


<210>  98

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  98
cggagttggg gaaacaatac tgg                                             23


<210>  99

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  99
gctcctcagc cgtcaggaac tgg                                             23


<210>  100

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  100
caccagggtg tccagctcaa tgg                                             23


<210>  101

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  101
ctagtcatat ttcaagtgac agg                                             23


<210>  102

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  102
gctgggcagc tccctcgccc ggg                                             23


<210>  103

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  103
tgtcagagcg gtcatcttcc agg                                             23


<210>  104

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  104
ctgggaggac ctgcgcaagc tgg                                             23


<210>  105

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  105
agctgggcag ctccctcgcc cgg                                             23


<210>  106

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  106
tgtgttgtgg ttgatgttgt tgg                                             23


<210>  107

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  107
cctgctgcct gtgtgacttt ggg                                             23


<210>  108

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  108
acctgctgcc tgtgtgactt tgg                                             23


<210>  109

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  109
gacgcggcat gtcatcagct ggg                                             23


<210>  110

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  110
ggtcatccac agacagagta ggg                                             23


<210>  111

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  111
agtcaagatc tttccctatg agg                                             23


<210>  112

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  112
gaacatactc cagttcctga cgg                                             23


<210>  113

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  113
acgtggagct gatgtcagag cgg                                             23


<210>  114

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  114
ggggaaaggt cgctttgctg agg                                             23


<210>  115

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  115
tctggaccct actctgtctg tgg                                             23


<210>  116

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  116
tgggcagctc cctcgcccgg ggg                                             23


<210>  117

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  117
agctgatgac atgccgcgtc agg                                             23


<210>  118

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  118
gccgcgtcag gtactcctgt agg                                             23


<210>  119

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  119
caagaggcat actcctcata ggg                                             23


<210>  120

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  120
ggtgagcaat cccccgggcg agg                                             23


<210>  121

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  121
ttgctggtgt tatattctga tgg                                             23


<210>  122

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  122
cctatgagga gtatgcctct tgg                                             23


<210>  123

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  123
tgctggtgtt atattctgat ggg                                             23


<210>  124

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  124
cgaggatatt ggagctcttg agg                                             23


<210>  125

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  125
gttgatgttg ttggcacacg tgg                                             23


<210>  126

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  126
tgacgcggca tgtcatcagc tgg                                             23


<210>  127

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  127
ttgagctgga caccctggtg ggg                                             23


<210>  128

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  128
ttcagagcag tttgagacag tgg                                             23


<210>  129

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  129
gcggcatgtc atcagctggg agg                                             23


<210>  130

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  130
aggtcatcca cagacagagt agg                                             23


<210>  131

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  131
gaagatgatg atgacagata tgg                                             23


<210>  132

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  132
tgacctggct aacagtgggc agg                                             23


<210>  133

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  133
tctactgcta ccgcgttaac cgg                                             23


<210>  134

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  134
gtccttctct gtcttccaag agg                                             23


<210>  135

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  135
attgagctgg acaccctggt ggg                                             23


<210>  136

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  136
gtcgttcttc acgaggatat tgg                                             23


<210>  137

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  137
catcagcctc ctgccaccac tgg                                             23


<210>  138

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  138
agttcctgac ggctgaggag cgg                                             23


<210>  139

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  139
actccagttc ctgacggctg agg                                             23


<210>  140

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  140
cttgaggtcc ctgtgcacga tgg                                             23


<210>  141

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  141
ttgaggtccc tgtgcacgat ggg                                             23


<210>  142

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  142
ccgcgtcttg ccggtttccc agg                                             23


<210>  143

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  143
gttgcccttg gcgtggaagg cgg                                             23


<210>  144

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  144
ctttgggctt tccctgcgtc tgg                                             23


<210>  145

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  145
gatcaccgcc ttccacgcca agg                                             23


<210>  146

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  146
tgaagtgttc tgcttcagct tgg                                             23


<210>  147

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  147
ctgtgcacga tgggcatctt ggg                                             23


<210>  148

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  148
ggcatcttgg gcctcccaca tgg                                             23


<210>  149

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  149
ttacctgccc actgttagcc agg                                             23


<210>  150

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  150
atcagcctcc tgccaccact ggg                                             23


<210>  151

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  151
tcgctttgct gaggtctata agg                                             23


<210>  152

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  152
agtcacacag gcagcaggtt agg                                             23


<210>  153

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  153
gaggagcgga agacggagtt ggg                                             23


<210>  154

<211>  23
<212>  DNA
<213>  homo sapiens

<220>
<223>  CRISPR target sequences for TGF&#946;RII gene

<400>  154
tgggcagcag ctctgtgttg tgg                                             23


<210>  155

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  R-TALEN TGFbRII pCLS32939

<400>  155
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccccagc aggtggtggc catcgccagc    480
aatggcggtg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaatggcgg tggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc    660
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc    780
gccagcaata atggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg    840
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa tggcggtggc    900
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccccagc aggtggtggc catcgccagc aatggcggtg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgacccccca gcaggtggtg   1080
gccatcgcca gcaatggcgg tggcaagcag gcgctggaga cggtccagcg gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccg gagcaggtgg tggccatcgc cagccacgat   1200
ggcggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cggagcaggt ggtggccatc gccagccacg atggcggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccggagcag   1380
gtggtggcca tcgccagcca cgatggcggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc   1500
cacgatggcg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag   1560
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gcaatattgg tggcaagcag   1620
gcgctggaga cggtgcaggc gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc   1680
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag   1740
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc   1800
gccagccacg atggcggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcaa tattggtggc   1920
aagcaggcgc tggagacggt gcaggcgctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  156

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  L-TALEN TGFbRII pCLS32940

<400>  156
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccggagc aggtggtggc catcgccagc    480
aatattggtg gcaagcaggc gctggagacg gtgcaggcgc tgttgccggt gctgtgccag    540
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaataatgg tggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccg    660
gagcaggtgg tggccatcgc cagccacgat ggcggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc    780
gccagcaata ttggtggcaa gcaggcgctg gagacggtgc aggcgctgtt gccggtgctg    840
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcaa tattggtggc    900
aagcaggcgc tggagacggt gcaggcgctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccggagc aggtggtggc catcgccagc cacgatggcg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   1080
gccatcgcca gcaatattgg tggcaagcag gcgctggaga cggtgcaggc gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccg gagcaggtgg tggccatcgc cagcaatatt   1200
ggtggcaagc aggcgctgga gacggtgcag gcgctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cccagcaggt ggtggccatc gccagcaata atggtggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1380
gtggtggcca tcgccagcaa tggcggtggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc   1500
cacgatggcg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag   1560
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gcaatattgg tggcaagcag   1620
gcgctggaga cggtgcaggc gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc   1680
cagcaggtgg tggccatcgc cagcaataat ggtggcaagc aggcgctgga gacggtccag   1740
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc   1800
gccagcaata atggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcaa tattggtggc   1920
aagcaggcgc tggagacggt gcaggcgctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  157

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  R-TALEN TGFbRII pCLS32967

<400>  157
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccggagc aggtggtggc catcgccagc    480
cacgatggcg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gccacgatgg cggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccg    660
gagcaggtgg tggccatcgc cagccacgat ggcggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc    780
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg    840
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcaa tattggtggc    900
aagcaggcgc tggagacggt gcaggcgctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccccagc aggtggtggc catcgccagc aatggcggtg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgacccccca gcaggtggtg   1080
gccatcgcca gcaataatgg tggcaagcag gcgctggaga cggtccagcg gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccg gagcaggtgg tggccatcgc cagcaatatt   1200
ggtggcaagc aggcgctgga gacggtgcag gcgctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cccagcaggt ggtggccatc gccagcaata atggtggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1380
gtggtggcca tcgccagcaa taatggtggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc   1500
aatattggtg gcaagcaggc gctggagacg gtgcaggcgc tgttgccggt gctgtgccag   1560
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaataatgg tggcaagcag   1620
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc   1680
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag   1740
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc   1800
gccagcaata ttggtggcaa gcaggcgctg gagacggtgc aggcgctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa tggcggtggc   1920
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  158

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  L-TALEN TGFbRII pCLS32968

<400>  158
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccccagc aggtggtggc catcgccagc    480
aataatggtg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gcaatattgg tggcaagcag    600
gcgctggaga cggtgcaggc gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc    660
cagcaggtgg tggccatcgc cagcaataat ggtggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc    780
gccagcaata ttggtggcaa gcaggcgctg gagacggtgc aggcgctgtt gccggtgctg    840
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcaa tattggtggc    900
aagcaggcgc tggagacggt gcaggcgctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccccagc aggtggtggc catcgccagc aataatggtg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   1080
gccatcgcca gcaatattgg tggcaagcag gcgctggaga cggtgcaggc gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccc cagcaggtgg tggccatcgc cagcaatggc   1200
ggtggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cccagcaggt ggtggccatc gccagcaata atggtggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1380
gtggtggcca tcgccagcaa tggcggtggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc   1500
cacgatggcg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag   1560
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gccacgatgg cggcaagcag   1620
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc   1680
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag   1740
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc   1800
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcca cgatggcggc   1920
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  159

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  TRAC TALEN target sequence

<400>  159
ttgtcccaca gatatccaga accctgaccc tgccgtgtac cagctgaga                 49


<210>  160

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD52 TALEN target sequence

<400>  160
ttcctcctac tcaccatcag cctcctggtt atggtacagg taagagcaa                 49


<210>  161

<211>  502
<212>  PRT
<213>  artificial

<220>
<223>  P4 CAR full sequence

<400>  161
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              


Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
65                  70                  75                  80  


Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr 
        115                 120                 125             


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Ile Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser 
                165                 170                 175     


Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn 
            180                 185                 190         


Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro 
        195                 200                 205             


Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly 
    210                 215                 220                 


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn 
225                 230                 235                 240 


Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp 
                245                 250                 255     


Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly 
            260                 265                 270         


Thr Gln Leu Thr Val Leu Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                325                 330                 335     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
            340                 345                 350         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        355                 360                 365             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    370                 375                 380                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
385                 390                 395                 400 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                405                 410                 415     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            420                 425                 430         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        435                 440                 445             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    450                 455                 460                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
465                 470                 475                 480 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                485                 490                 495     


Gln Ala Leu Pro Pro Arg 
            500         


























