                         SEQUENCE LISTING

<110>  Albert Ludwigs Universitt
 
<120>  Chimeric antigen receptors that bind to prostate specific 
       membrane antigen

<130>  PEP 03531 ALB

<140>  EP 19219238.3
<141>  2019-12-23

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  murine sequence

<400>  1

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ile Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Leu Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR - H1

<400>  2

Gly Phe Thr Phe Ser Asp Tyr Tyr Met 
1               5                   


<210>  3
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H2

<400>  3

Ile Ile Ser Asp Gly Gly Tyr 
1               5           


<210>  4
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H3

<400>  4

Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr 
1               5                   10          


<210>  5
<211>  107
<212>  PRT
<213>  murine sequence

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Asp Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-L1

<400>  6

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-L2

<400>  7

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-L3

<400>  8

Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  9
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H1

<400>  9

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H2

<400>  10

Ile Ser Asp Gly Gly Tyr Tyr Thr 
1               5               


<210>  11
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H3

<400>  11

Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
1               5                   10                  15      


<210>  12
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-L1 IMGT

<400>  12

Gln Asn Val Asp Thr Asn 
1               5       


<210>  13
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-L2 IMGT

<400>  13

Ser Ala Ser 
1           


<210>  14
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-L3 IMGT

<400>  14

Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr 
1               5                   


<210>  15
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum-A5-VH1 coding strand

<400>  15
gacgtgaaac tcgtggaatc aggcggtggg ttggttaaac cgggtgaatc cctccgcctc       60

tcttgcgcgg cgagcgggtt cacattttca gattattata tgtattggat ccgacaaact      120

cctgaaaaac ggcttgaatg ggttgccatt atttcagatg gcggatatta cacttactat      180

tctgacattg tgaaaggtcg ctttacaatc tccagggaca atgcgaaaaa caacctgtac      240

ttgcaaatgt ctagcctgcg atcagaggat actgcaatgt actactgcac ccgcggattt      300

ccgcttctgc gacatggagc tatggactac tggggtctcg gcacgagtgt aacggtgagt      360

agt                                                                    363


<210>  16
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5- VH1

<400>  16

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Leu Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VH2 coding strand

<400>  17
caagtccaac tggtggaatc tggtggtggt cttgttaaac caggggaaag tctgcgactg       60

agctgcgccg cgagtgggtt cacgttttcc gactactata tgagctggat tagacagacg      120

cctgagaaac gactcgagtg ggttagtatt attagtgatg gagggtatta cacctactat      180

gcagatatcg ttaaagggcg atttactatc agccgagata acgcaaaaaa caacttgtat      240

ctccaaatgt cctcactgcg ggctgaggat accgctgtat attactgtac caggggtttt      300

cctctcctgc ggcacggggc tatggattat tggggtttgg ggacctcagt tacggtatca      360

tcc                                                                    363


<210>  18
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VH2

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Leu Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VH3 coding strand

<400>  19
caggtacaac tggtggaaag cgggggagga cttgtcaagc ccggagggtc cctcagattg       60

agctgtgcgg cctccgggtt caccttttcc gattactata tgtcctggat tcggcaggca      120

ccgggtaagg gattggagtg ggtatcttat ataagcgacg ggggctatta tacttattac      180

gctgatagtg tgaaagggcg cttcactatc agccgagaca atgcgaagaa ttctttgtat      240

ttgcagatga attctttgag agccgaggat acagcggttt attactgtac gagagggttt      300

ccacttctga ggcatggtgc gatggattat tggggactgg gtactagcgt caccgtaagc      360

tct                                                                    363


<210>  20
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VH3

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Leu Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VH4

<400>  21
caagtacagt tggttgaaag tggtggcggc ctcgttaagc ctggcggatc tctgagattg       60

tcttgtgctg cgtctggatt cactttttcc gactattata tgtattgggt gagacagaca      120

ccagaaaaaa ggcttgaatg ggtcgccata atatccgatg ggggttatta tacttactac      180

gctgacagca taaaagggag attcacgata agccgggata atgccaaaaa tagtctttat      240

ctccaaatga actctctgag agcggaagat actgctgtat actattgcac tagagggttc      300

ccattgttga gacatggagc aatggattac tgggggcaag ggactctcgt aaccgtctca      360

tct                                                                    363


<210>  22
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VH4

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VH5 coding strand

<400>  23
caggttcaac tcgttgagag cggtggcggc cttgtgaaac cgggtggctc cctgaggttg       60

agctgtgcgg cctcagggtt cacctttagt gactactaca tgtactgggt ccggcaggcc      120

ccaggcaaag gcttggagtg ggttgcgatc attagcgacg gtgggtacta tacatattac      180

gccgattccg tcaaagggcg atttacgatt agtcgcgaca acgcgaaaaa ctcattgtac      240

cttcaaatga actctctcag agctgaagat actgcggtgt actactgtac gagggggttt      300

cctttgctta ggcacggggc catggactat tggggccaag gcaccctcgt aacggtttcc      360

tct                                                                    363


<210>  24
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VH5

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  25
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VL1

<400>  25
gacattcaaa tgacccaaag cccgaaattc ttgtctacct ccgttggtga cagagtgacg       60

attacgtgta gggctagtca gaacgtggat acgaacttgg cctggtatca gcagaagcca      120

ggacagtctc caaaagcctt gatatatagc gcaagctacc gatactccga tgttccggac      180

cgattttcag ggtcagagag tggcacagat tttacgctta caattagcaa cctgcaatcc      240

gaggacctcg ccgagtattt ctgtcaacaa tatgattcct atccatacac ttttggtggg      300

ggcactaaac ttgagataaa g                                                321


<210>  26
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VL1

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Lys Phe Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Asp Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VL2 coding strand

<400>  27
gacattcaga tgacgcagag cccaaagttt ttgtctacaa gtgttggtga tagagtcact       60

atcacgtgca gggcttctca gaatgtagac actaacctgg cctggttcca gcagaagcca      120

ggaaaggctc ccaaatcact catctactct gcatcatccc tctattctga cgtgccggac      180

cgattctcag gctccgagtc cggcaccgac tttacgttga cgatcagcaa tcttcagccg      240

gaggattttg ctgaatacta ttgtcagcag tacgattcct atccatacac attcggtggg      300

ggaaccaagt tggaaataaa g                                                321


<210>  28
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VL2

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Lys Phe Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Asp Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Glu Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  29
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VL3

<400>  29
gacattcaga tgactcagtc tcccagctca ttgtcagctt cagtaggcga ccgagtgact       60

attacctgta gagcatctca aaatgtggat acaaaccttg catggtttca gcagaaaccc      120

ggaaaagccc cgaaaagttt gatttactcc gcctcatctc tccaatccgg cgtgcccagc      180

cggtttagtg gcagcggaag tgggactgac ttcaccctca cgatctctag ccttcagcca      240

gaagacttcg cgacgtatta ttgccaacaa tacgatagct atccatatac gttcggggga      300

ggcaccaaac tggagataaa g                                                321


<210>  30
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VL3

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VL4

<400>  31
gatatacaga tgacacagtc tcccagctct atgagtacct ccgttggaga ccgggtcact       60

gtaacatgca gagcctctca aaacgtagac actaatgtag catggtacca gcaaaagcct      120

ggaaaagccc cgaaagcgtt gatatattcc gcttcctaca gatattctgg ggtaccagat      180

cgcttctctg gcagtggaag tgggaccgac tttactctga cgatcagctc cgtccagcct      240

gaagatttgg ctacttactt ttgtcagcaa tatgactcct acccatacac attcggtggg      300

ggtaccaaat tggaaataaa g                                                321


<210>  32
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VL4

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Phe Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 VL5

<400>  33
gacatccaaa tgacacaatc accttctagc ctctcagcgt cagtgggcga tagggttact       60

attacttgcc gcgcgagcca gaatgttgat acgaatgtgg cctggtatca gcagaagccg      120

ggtaaggctc cgaaggcact gatttattcc gcctcctacc gatattccgg cgtacccgac      180

aggttcagtg gttccgggtc aggtacggac tttacgctta ctatatcctc cctgcagcct      240

gaggacgtag ccacttattt ttgccagcag tatgacagtt acccatatac atttggtcaa      300

ggtacaaaat tggagatcaa g                                                321


<210>  34
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5 VL5

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  hum A5 - VL6

<400>  35
gatatacaga tgacgcaaag tccatcatcc ctcagcgcaa gcgtgggaga cagagtcaca       60

attacttgcc gcgcgagtca gaacgtagat acgaacctgg cttggtatca gcagaaaccg      120

ggaaaggctc ccaagtcact gatctactca gccagctacc tgtatagcgg tgttccaagt      180

cgcttttcag gttcaggcag cggcactgac ttcacattga ctatatcctc ccttcagccc      240

gaagatgtcg ccacttattt ttgccaacaa tatgactcct atccctatac tttcggacag      300

gggaccaaat tggagataaa a                                                321


<210>  36
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hum A5- VL6

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  37
<211>  2055
<212>  DNA
<213>  artificial sequence

<220>
<223>  A5CAR28, coding strand

<400>  37
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtct       60

agagacgtta agttggtgga gagtggagga ggtttggtaa aaccaggaga atcccttaaa      120

ctctcttgca ttgcctcagg ctttaccttt tccgattatt atatgtattg ggtccgacaa      180

acacccgaaa aacgattgga atgggttgca attatatctg acggtggcta ctacacatat      240

tattctgata ttatcaaggg tagatttact atctccaggg ataatgccaa aaataatctc      300

taccttcaga tgtcttccct caaaagtgaa gatacggcca tgtattattg cacacgcggt      360

tttccattgc ttaggcacgg ggcaatggat tactggggac ttggtacctc cgtcacggta      420

agttctggcg gtggcggaag tggaggcggg ggttctggtg gtggggggtc tgacatccag      480

atgactcaaa gccctaaatt catgagcacg tcagttggag atcgagtctc cgttacgtgt      540

aaggcttctc aaaatgtaga cactaacgtc gcatggtacc aacagaagcc aggccagtct      600

ccgaaagccc tgatctacag cgcttcatac aggtattctg acgtacccga ccgattcact      660

ggatcagaga gtggaactga ctttaccctt accatcagca acgtacaatc cgaggatctc      720

gcagaatatt tttgccaaca gtacgattcc tatccatata ctttcggcgg aggcacgaag      780

cttgaaatca agtcggatcc cgccgagccc aaatctcctg acaaaactca cacatgccca      840

ccgtgcccag cacctccagt cgcgggaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatcgcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaaaaa     1500

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta     1560

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt     1620

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccaggcctat     1680

gccgccgcac gcgacttcgc agcctatcgc tccctgagag tgaagttcag caggagcgca     1740

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1800

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1860

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1920

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1980

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     2040

ctgccccctc gctaa                                                      2055


<210>  38
<211>  2043
<212>  DNA
<213>  artificial sequence

<220>
<223>  A5CAR41,coding strand

<400>  38
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtct       60

agagacgtta agttggtgga gagtggagga ggtttggtaa aaccaggaga atcccttaaa      120

ctctcttgca ttgcctcagg ctttaccttt tccgattatt atatgtattg ggtccgacaa      180

acacccgaaa aacgattgga atgggttgca attatatctg acggtggcta ctacacatat      240

tattctgata ttatcaaggg tagatttact atctccaggg ataatgccaa aaataatctc      300

taccttcaga tgtcttccct caaaagtgaa gatacggcca tgtattattg cacacgcggt      360

tttccattgc ttaggcacgg ggcaatggat tactggggac ttggtacctc cgtcacggta      420

agttctggcg gtggcggaag tggaggcggg ggttctggtg gtggggggtc tgacatccag      480

atgactcaaa gccctaaatt catgagcacg tcagttggag atcgagtctc cgttacgtgt      540

aaggcttctc aaaatgtaga cactaacgtc gcatggtacc aacagaagcc aggccagtct      600

ccgaaagccc tgatctacag cgcttcatac aggtattctg acgtacccga ccgattcact      660

ggatcagaga gtggaactga ctttaccctt accatcagca acgtacaatc cgaggatctc      720

gcagaatatt tttgccaaca gtacgattcc tatccatata ctttcggcgg aggcacgaag      780

cttgaaatca agtcggatcc cgccgagccc aaatctcctg acaaaactca cacatgccca      840

ccgtgcccag cacctccagt cgcgggaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatcgcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct cgagcctgtc tccgggtaaa     1500

aaaatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct gtcactggtt     1560

atcacccttt actgcaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1620

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1680

gaagaaggag gatgtgaact gctgagagtg aagttcagca ggagcgcaga cgcccccgcg     1740

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1800

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     1860

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1920

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1980

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     2040

taa                                                                   2043


<210>  39
<211>  684
<212>  PRT
<213>  artificial sequence

<220>
<223>  A5CAR28

<400>  39

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Glu Ser Leu Lys Leu Ser Cys Ile Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asp Tyr Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ile Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Asn Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Leu Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
                165                 170                 175     


Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala 
        195                 200                 205             


Ser Tyr Arg Tyr Ser Asp Val Pro Asp Arg Phe Thr Gly Ser Glu Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
225                 230                 235                 240 


Ala Glu Tyr Phe Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Ser Asp Pro Ala Glu Pro Lys Ser 
            260                 265                 270         


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
            500                 505                 510         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        515                 520                 525             


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    530                 535                 540                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Ala Tyr 
545                 550                 555                 560 


Ala Ala Ala Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe 
                565                 570                 575     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            580                 585                 590         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        595                 600                 605             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    610                 615                 620                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
625                 630                 635                 640 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                645                 650                 655     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            660                 665                 670         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 


<210>  40
<211>  680
<212>  PRT
<213>  artificial sequence

<220>
<223>  A5CAR41

<400>  40

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Glu Ser Leu Lys Leu Ser Cys Ile Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asp Tyr Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Ile Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Asn Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Leu Gly Thr Ser Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
                165                 170                 175     


Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala 
        195                 200                 205             


Ser Tyr Arg Tyr Ser Asp Val Pro Asp Arg Phe Thr Gly Ser Glu Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu 
225                 230                 235                 240 


Ala Glu Tyr Phe Cys Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Ser Asp Pro Ala Glu Pro Lys Ser 
            260                 265                 270         


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            500                 505                 510         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
        515                 520                 525             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    530                 535                 540                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
545                 550                 555                 560 


Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                565                 570                 575     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            580                 585                 590         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        595                 600                 605             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    610                 615                 620                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
625                 630                 635                 640 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                645                 650                 655     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            660                 665                 670         


His Met Gln Ala Leu Pro Pro Arg 
        675                 680 


<210>  41
<211>  729
<212>  DNA
<213>  artificial seqence

<220>
<223>  murine sequence scFv A5

<400>  41
gacgttaagt tggtggagag tggaggaggt ttggtaaaac caggagaatc ccttaaactc       60

tcttgcattg cctcaggctt taccttttcc gattattata tgtattgggt ccgacaaaca      120

cccgaaaaac gattggaatg ggttgcaatt atatctgacg gtggctacta cacatattat      180

tctgatatta tcaagggtag atttactatc tccagggata atgccaaaaa taatctctac      240

cttcagatgt cttccctcaa aagtgaagat acggccatgt attattgcac acgcggtttt      300

ccattgctta ggcacggggc aatggattac tggggacttg gtacctccgt cacggtaagt      360

tctggcggtg gcggaagtgg aggcgggggt tctggtggtg gggggtctga catccagatg      420

actcaaagcc ctaaattcat gagcacgtca gttggagatc gagtctccgt tacgtgtaag      480

gcttctcaaa atgtagacac taacgtcgca tggtaccaac agaagccagg ccagtctccg      540

aaagccctga tctacagcgc ttcatacagg tattctgacg tacccgaccg attcactgga      600

tcagagagtg gaactgactt tacccttacc atcagcaacg tacaatccga ggatctcgca      660

gaatattttt gccaacagta cgattcctat ccatatactt tcggcggagg cacgaagctt      720

gaaatcaag                                                              729


<210>  42
<211>  243
<212>  PRT
<213>  murine scFv A5

<400>  42

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ile Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Leu Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
            180                 185                 190         


Asp Val Pro Asp Arg Phe Thr Gly Ser Glu Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


