                         SEQUENCE LISTING

<110>  Adagene (Suzhou)  Limited
 
<120>  ANTI-CSF1R MOLECULES AND USE THEREOF

<130>  

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  1

Phe Thr Phe Ser Gly Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Tyr Thr Phe Ser Asp Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  3
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  3

Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Phe Thr Phe Ser Asp Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  5

Phe Thr Phe Ser Asn Tyr Gly Ile His Trp Val 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Tyr Thr Phe Ser Asn Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  7
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  7

Tyr Ser Ile Thr Ser Gly His His Trp Ala Trp Ile 
1               5                   10          


<210>  8
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Phe Thr Phe Thr Asp Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  9

Tyr Thr Phe Ser Ser Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  10

Phe Thr Phe Ser Asn Tyr Ala Ile His Trp Val 
1               5                   10      


<210>  11
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  11

Val Ser Val Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  12
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  12

Val Ser Val Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  13
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  13

Val Ser Ser Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  14
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  14

Val Ser Val Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  15
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15

Val Ser Val Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  16
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  16

Val Ser Ala Ile Ser Gly Thr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  17
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  17

Val Ser Ser Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  18
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  18

Val Ser Val Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  19
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  19

Val Ser Val Ile Ser Gly Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  20
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  20

Val Ser Val Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe 
            20      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  21

Ala Arg Asp Pro Gly Val Gly Gly Phe Asp Val 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22

Ala Arg Ala Ser Ser Tyr Gly Gly Phe Asp Tyr 
1               5                   10      


<210>  23
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  23

Ala Arg Gly Ala Tyr Gly Tyr Phe Asp Tyr 
1               5                   10  


<210>  24
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24

Ala Arg Ser Gly Gly Gly Gly Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  25

Ala Arg Arg Gly Leu Thr Ser Thr Tyr Phe Asp Tyr 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  26

Ala Arg His Ser His Ser Arg Tyr Ala Phe Asp Tyr 
1               5                   10          


<210>  27
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  27

Ala Arg Gly Ser Tyr Tyr Gly Ala Gly Ser Phe Asp Tyr 
1               5                   10              


<210>  28
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  28

Ala Arg Gly Ser Tyr Ser Ser Val Tyr Phe Asp Val 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  29

Ala Arg Arg Thr Pro Ala Gly Asn Tyr Phe Asp Tyr 
1               5                   10          


<210>  30
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  30

Ala Arg Ser Thr Val Ala Thr Pro Phe Ala Tyr 
1               5                   10      


<210>  31
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  31

Arg Ala Ser Gln Ser Val Arg Arg Arg Phe Leu Ala 
1               5                   10          


<210>  32
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  32

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  33
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  33

Pro Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  34
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  34

Arg Ala Ser Gln Gly Ile Arg Ser Tyr Leu Ala 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  35

Arg Ala Ser Gln Ser Val Gly Ser Trp Leu Ala 
1               5                   10      


<210>  36
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  36

Arg Ala Ser His Val Arg Thr Ala Val Ala 
1               5                   10  


<210>  37
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  37

Arg Ala Ser Gln Gly Ile Thr Ser Ala Leu Ala 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  38

Lys Ala Ser Gln Asp Val Arg Thr Ala Val Ala 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  39

Arg Ala Ser Gln Gly Ile Ser Arg Trp Leu Ala 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  40

Lys Ala Ser Gln Asp Val Arg Thr Ala Val Ala 
1               5                   10      


<210>  41
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  41

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  42

Asp Ala Ser Asn Arg Ala Thr Gly Ile 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  43

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  44

Ala Ala Ser Ser Leu Gln Ser Gly Val 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  45

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  46

Asp Ala Ser Asn Leu Glu Thr Gly Val 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  47

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  48

Ala Ala Ser Ser Leu Gln Ser Gly Val 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  49

Asp Ala Ser Ser Leu Glu Ser Gly Val 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  50

Ala Ala Ser Thr Leu Gln Ser Gly Val 
1               5                   


<210>  51
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  51

Tyr Cys Gln Gln Tyr Tyr Pro Ile Pro Arg Thr 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  52

Tyr Cys Gln Gln Tyr Tyr Pro Trp Pro Trp Thr 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  53

Tyr Cys Gln Gln Tyr Tyr Pro Trp Pro Trp Thr 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  54

Tyr Cys Gln Gln Ser Tyr His Trp Pro Leu Thr 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  55

Tyr Cys Gln Gln Ser Tyr Pro Ile Pro Pro Thr 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  56

Tyr Cys Gln Gln Tyr Tyr Pro Trp Pro Trp Thr 
1               5                   10      


<210>  57
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  57

Tyr Cys Gln Gln Tyr Tyr Pro Trp Pro Trp Thr 
1               5                   10      


<210>  58
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  58

Tyr Cys Gln Gln Ser Tyr Pro Ile Pro Phe Thr 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  59

Tyr Cys Glu Gln Tyr Leu Glu Val Pro Pro Thr 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  60

Tyr Cys Gln Gln Ser Tyr Pro Trp Pro Trp Thr 
1               5                   10      


<210>  61
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Val Gly Gly Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  62
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Ser Tyr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  63
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ser Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ala Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  64
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Gly Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  65
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Thr Ser Thr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  66
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Thr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser His Ser Arg Tyr Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


His His Trp Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Ser Ile Ser Gly Ser Gly Ser Thr Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ser Tyr Tyr Gly Ala Gly Ser Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  68
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Ser Ser Val Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Thr Pro Ala Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Val Ala Thr Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  71
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  71

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Arg Arg Arg 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Pro Ile Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  72
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  72

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Pro Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  73
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  73

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Pro Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Pro Trp Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  74
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  74

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr His Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  75
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  75

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Pro Ile Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  76
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  76

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Val Arg Thr Ala Val 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Pro Trp Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  77
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  77

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Pro Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  78
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  78

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Pro Ile Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  79
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  79

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Glu Gln Tyr Leu Glu Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  80
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  80

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Pro Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  81
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Thr Asp Gly Gly Thr Asn Tyr Ala Gln Lys Leu Gln 
    50                  55                  60                  


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gln Arg Leu Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  82
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Val Asn Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  83
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Gly Thr Thr Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Pro Tyr Phe Ser Asn Leu Tyr Val Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  84
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  84

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Leu Ser Asn 
                85                  90                  95      


Glu Asp Leu Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  85
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  86
<211>  976
<212>  PRT
<213>  Macaca fascicularis

<400>  86

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Val Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Gly Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Glu Met Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Ile Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Pro Ser Ser Val Leu Thr Thr Thr Asn Ala Thr Phe Gln Asn Thr Arg 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Lys Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Leu Arg 
    130                 135                 140                 


Gly Arg Pro Leu Leu Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Gly Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Ser Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Glu Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Asn Ile Asp Val Asp Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Thr Thr Lys Leu Ala Ile Pro Gln Arg Ser Asp Phe His Asp Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Ser Leu Gly Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asp Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Cys Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Ser Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ala Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Val Asp Pro His Pro Glu Val Leu Ser Gln Glu Pro Phe Gln 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Ala Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala Arg Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Val Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Ala Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Trp Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Leu Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Gly Ser Ser Ser Ser Ser Ser 
    930                 935                 940                 


Glu Pro Glu Glu Glu Ser Ser Ser Glu His Leu Ala Cys Cys Glu Gln 
945                 950                 955                 960 


Gly Asp Ile Ala Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970                 975     


<210>  87
<211>  977
<212>  PRT
<213>  Mus musculus

<400>  87

Met Glu Leu Gly Pro Pro Leu Val Leu Leu Leu Ala Thr Val Trp His 
1               5                   10                  15      


Gly Gln Gly Ala Pro Val Ile Glu Pro Ser Gly Pro Glu Leu Val Val 
            20                  25                  30          


Glu Pro Gly Glu Thr Val Thr Leu Arg Cys Val Ser Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Ile Ser Pro Tyr Trp Thr Leu Asp Pro Glu Ser 
    50                  55                  60                  


Pro Gly Ser Thr Leu Thr Thr Arg Asn Ala Thr Phe Lys Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Leu Glu Asp Pro Met Ala Gly Ser Thr Thr 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala His Ser Trp Asn Leu Leu Ala 
            100                 105                 110         


Gln Glu Val Thr Val Val Glu Gly Gln Glu Ala Val Leu Pro Cys Leu 
        115                 120                 125             


Ile Thr Asp Pro Ala Leu Lys Asp Ser Val Ser Leu Met Arg Glu Gly 
    130                 135                 140                 


Gly Arg Gln Val Leu Arg Lys Thr Val Tyr Phe Phe Ser Pro Trp Arg 
145                 150                 155                 160 


Gly Phe Ile Ile Arg Lys Ala Lys Val Leu Asp Ser Asn Thr Tyr Val 
                165                 170                 175     


Cys Lys Thr Met Val Asn Gly Arg Glu Ser Thr Ser Thr Gly Ile Trp 
            180                 185                 190         


Leu Lys Val Asn Arg Val His Pro Glu Pro Pro Gln Ile Lys Leu Glu 
        195                 200                 205             


Pro Ser Lys Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Thr Asn Ala Glu Val Gly Phe Asn Val Ile Leu Lys Arg Gly 
225                 230                 235                 240 


Asp Thr Lys Leu Glu Ile Pro Leu Asn Ser Asp Phe Gln Asp Asn Tyr 
                245                 250                 255     


Tyr Lys Lys Val Arg Ala Leu Ser Leu Asn Ala Val Asp Phe Gln Asp 
            260                 265                 270         


Ala Gly Ile Tyr Ser Cys Val Ala Ser Asn Asp Val Gly Thr Arg Thr 
        275                 280                 285             


Ala Thr Met Asn Phe Gln Val Val Glu Ser Ala Tyr Leu Asn Leu Thr 
    290                 295                 300                 


Ser Glu Gln Ser Leu Leu Gln Glu Val Ser Val Gly Asp Ser Leu Ile 
305                 310                 315                 320 


Leu Thr Val His Ala Asp Ala Tyr Pro Ser Ile Gln His Tyr Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Phe Glu Asp Gln Arg Lys Leu Glu Phe Ile 
            340                 345                 350         


Thr Gln Arg Ala Ile Tyr Arg Tyr Thr Phe Lys Leu Phe Leu Asn Arg 
        355                 360                 365             


Val Lys Ala Ser Glu Ala Gly Gln Tyr Phe Leu Met Ala Gln Asn Lys 
    370                 375                 380                 


Ala Gly Trp Asn Asn Leu Thr Phe Glu Leu Thr Leu Arg Tyr Pro Pro 
385                 390                 395                 400 


Glu Val Ser Val Thr Trp Met Pro Val Asn Gly Ser Asp Val Leu Phe 
                405                 410                 415     


Cys Asp Val Ser Gly Tyr Pro Gln Pro Ser Val Thr Trp Met Glu Cys 
            420                 425                 430         


Arg Gly His Thr Asp Arg Cys Asp Glu Ala Gln Ala Leu Gln Val Trp 
        435                 440                 445             


Asn Asp Thr His Pro Glu Val Leu Ser Gln Lys Pro Phe Asp Lys Val 
    450                 455                 460                 


Ile Ile Gln Ser Gln Leu Pro Ile Gly Thr Leu Lys His Asn Met Thr 
465                 470                 475                 480 


Tyr Phe Cys Lys Thr His Asn Ser Val Gly Asn Ser Ser Gln Tyr Phe 
                485                 490                 495     


Arg Ala Val Ser Leu Gly Gln Ser Lys Gln Leu Pro Asp Glu Ser Leu 
            500                 505                 510         


Phe Thr Pro Val Val Val Ala Cys Met Ser Val Met Ser Leu Leu Val 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro Lys Tyr 
    530                 535                 540                 


Gln Val Arg Trp Lys Ile Ile Glu Arg Tyr Glu Gly Asn Ser Tyr Thr 
545                 550                 555                 560 


Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu Phe Pro 
                565                 570                 575     


Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly 
            580                 585                 590         


Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp Ala Val 
        595                 600                 605             


Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala Asp Glu 
    610                 615                 620                 


Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu Gly Gln 
625                 630                 635                 640 


His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly Gly Pro 
                645                 650                 655     


Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe 
            660                 665                 670         


Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser Pro Gly 
        675                 680                 685             


Gln Asp Ser Glu Gly Asp Ser Ser Tyr Lys Asn Ile His Leu Glu Lys 
    690                 695                 700                 


Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val Asp Thr 
705                 710                 715                 720 


Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Ser Asp Ser Phe Phe 
                725                 730                 735     


Lys Gln Asp Leu Asp Lys Glu Ala Ser Arg Pro Leu Glu Leu Trp Asp 
            740                 745                 750         


Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe Leu Ala 
        755                 760                 765             


Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val Leu Leu 
    770                 775                 780                 


Thr Ser Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp 
785                 790                 795                 800 


Ile Met Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
                805                 810                 815     


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr Thr Val 
            820                 825                 830         


Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser 
        835                 840                 845             


Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Asn Lys Phe Tyr 
    850                 855                 860                 


Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Val Phe Ala Pro 
865                 870                 875                 880 


Lys Asn Ile Tyr Ser Ile Met Gln Ser Cys Trp Asp Leu Glu Pro Thr 
                885                 890                 895     


Arg Arg Pro Thr Phe Gln Gln Ile Cys Phe Leu Leu Gln Glu Gln Ala 
            900                 905                 910         


Arg Leu Glu Arg Arg Asp Gln Asp Tyr Ala Asn Leu Pro Ser Ser Gly 
        915                 920                 925             


Gly Ser Ser Gly Ser Asp Ser Gly Gly Gly Ser Ser Gly Gly Ser Ser 
    930                 935                 940                 


Ser Glu Pro Glu Glu Glu Ser Ser Ser Glu His Leu Ala Cys Cys Glu 
945                 950                 955                 960 


Pro Gly Asp Ile Ala Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe 
                965                 970                 975     


Cys 
    


