                         SEQUENCE LISTING

<110>  NemaMetrix, Inc
 
<120>  MODEL ORGANISMS HUMANIZED FOR DRUG DISCOVERY AND SCREENING

<130>  NEMA011.PCT

<150>  US62/952,218
<151>  2019-12-21

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  1830
<212>  DNA
<213>  C. elegans

<400>  1
atggctagca gcgctgagct acatcaaggg gaacgtgaaa catggggaaa gaaagtcgac       60

ttcctcctct ccgtcatcgg atacgccgtc gacctcggaa acgtctggcg tttcccatac      120

atctgctacc aaaacggagg aggagccttc ctcctcccat acaccatcat ggccatcttc      180

ggaggaatcc cactcttcta catggagctc gccctcggac aataccaccg taacggatgc      240

atctccatct ggcgtaagat ctgcccaatc ttcaagggaa tcggatacgc catctgcatc      300

atcgccttct acatcgcctc ttactacaac accatcatgg cctgggccct ctactacctc      360

atctcctcct tcaccgacca actcccatgg acctcctgca aggtacttga gatccttaaa      420

cgcagtcgaa aattggtaat tttacagaac tcctggaaca ccggaaactg caccaactac      480

ttctccgagg acaacatcac ctggaccctc cactccacct ccccagccga ggagttctac      540

acccgtcacg tcctccaaat ccaccgttcc aagggactcc aagacctcgg aggaatctcc      600

tggcaactcg ccctctgcat catgctcatc ttcaccgtca tctacttctc catctggaag      660

ggagtcaaga cctccggaaa ggtcgtctgg gtcaccgcca ccttcccata catcatcctc      720

tccgtcctcc tcgtccgtgg agccaccctc ccaggagcct ggcgtggagt cctcttctac      780

ctcaagccaa actggcaaaa gctcctcgag accggagtct ggatcgacgc cgccgcccaa      840

atcttcttct ccctcggacc aggattcgga gtcctcctcg ccttcgcctc ctacaacaag      900

ttcaacaaca actgctacca agacgccctc gtcacctccg tcgtcaactg catgacctcc      960

ttcgtctccg gattcgtcat cttcaccgtc ctcggataca tggccgagat gcgtaacgag     1020

gacgtctccg aggtcgccaa ggtaagttcc tccactagaa atatcaggtg ctataattgt     1080

gttcaggacg ccggaccatc cctcctcttc atcacctacg ccgaggccat cgccaacatg     1140

ccagcctcca ccttttttgc catcattttc ttcctcatgc ttataaccct cggactcgac     1200

tccaccttcg ccggactcga gggagtcatc actgccgtcc tcgacgagtt cccacacgtc     1260

tgggccaagc gtcgtgagcg tttcgtcctc gccgtcgtca tcacctgctt cttcggatcc     1320

ctcgtcaccc tcaccttcgg aggagcctac gtcgtcaagc tcctcgagga gtacgccacc     1380

ggaccagccg tcctcaccgt cgccctcatc gaggccgtcg ccgtctcctg gttctacgga     1440

atcacccaat tctgccgtga cgtcaaggtg agttattata atttttttga tcacaacgat     1500

tattttaatt ttcaggagat gctcggattc tccccaggat ggttctggcg tatctgctgg     1560

gtcgccatct ccccactctt cctcctcttc atcatctgct ccttcctcat gtccccacca     1620

caactccgtc tcttccaata caactaccca tactggtcca tcatcctcgg atactgcatc     1680

ggaacctcct ccttcatctg catcccaacc tacatcgcct accgtctcat catcacccca     1740

ggaaccttca aggagcgtat catcaagtcc atcaccccag agaccccaac cgagatccca     1800

tgcggagaca tccgtctcaa cgccgtctaa                                      1830


<210>  2
<211>  45
<212>  DNA
<213>  C. elegans

<400>  2
gtacttgaga tccttaaacg cagtcgaaaa ttggtaattt tacag                       45


<210>  3
<211>  45
<212>  DNA
<213>  C. elegans

<400>  3
gtaagttcct ccactagaaa tatcaggtgc tataattgtg ttcag                       45


<210>  4
<211>  48
<212>  DNA
<213>  C. elegans

<400>  4
gtgagttatt ataatttttt tgatcacaac gattatttta attttcag                    48


<210>  5
<211>  2799
<212>  DNA
<213>  C. elegans

<400>  5
atgctaacaa ccggtggatc gggtggatcg atggtacaaa agtccagaaa tggtggagtt       60

tacccgggtc catctggtga aaaaaaattg aaagtaggat ttgtcggcct cgaccctgga      120

gcgccggaca gtaccagaga tggcgcgctg ttgatcgctg gttcggaggc accgaaacga      180

ggaagtattc tcagtaagcc tcgtgcggga ggtgccggcg ctggaaaacc gcctaaaaga      240

aatgcctttt acagaaagct gcagaacttc ttgtataatg tgctggaacg accgagaggc      300

tgggcattta tttatcacgc ctacgttttc ttgcttgttt tctcctgcct tgtgttgagt      360

gttttctcca ccataaaaga atacgaaaaa agttccgagg gtgctcttta catcctcgaa      420

attgtcacca tcgtggtgtt cggagtggaa tactttgtta gaatttgggc cgctggctgc      480

tgctgccgat accgaggctg gcgaggtcgt ctgaaatttg ctcgaaaacc gttctgtgtc      540

atcgacatta tggttctgat cgcaagtatt gctgtcttgg cggcgggatc tcagggcaat      600

gtgtttgcaa cctcggccct tagatccctc cgatttttac aaatcctccg tatgatccgt      660

atggaccgac gtggtggaac ttggaaactt cttggatccg tcgtctacgc ccactccaag      720

gtgagtgatt ttaaacatta tctgtactta aattataaat tctctattca ggaactcgtc      780

accgcctggt acatcggatt cttgtgtctt atcctggcat cgtttcttgt ttacttggcc      840

gaaaagggtg aaaacgatca ctttgacaca tatgccgatg cgttgtggtg gggcttgatc      900

actcttacga caattggata tggtgacaag tatccgcaga catggaatgg tagacttctt      960

gctgccacct tcaccctgat cggtgtcagt ttcttcgccc tcccagctgg catcctgggc     1020

tcaggttttg cgctgaaggt ccaagagcag caccgacaaa aacactttga aaagcgacgt     1080

aaccctgccg ctggtttgat tcaatccgct tggagattct acgctacgaa cttgtctcgt     1140

accgatctgc actctacctg gcaatactac gaaagaacgg taacagtgcc gatgtattcg     1200

tcccaaactc aaacttacgg agcttcaaga ctgattccac cgctgaacca gctggagctg     1260

ttgcgaaacc ttaaatcaaa atctggcctg gctttccgaa aggatcctcc tccggagcct     1320

tcgccttcta agggaagtcc ttgcagaggc ccgctttgcg gttgctgccc aggacgttcc     1380

tcccaaaagg taaataatta tacattcgat gataaattta tgcgtactat ttttcaggtc     1440

tccctcaagg accgtgtctt ctcctccccg agaggcgtag cagccaaggg aaagggaagt     1500

ccacaagcac aaactgttcg aagatcgcct tcagcggacc aatcattgga agactcgcca     1560

tcaaaggtgc ctaaatcctg gtcctttggt gaccgttcga gagcaagaca ggccttccgt     1620

atcaagggtg cggcatctcg acagaattcg gaagaagctt cactcccagg cgaggacatc     1680

gtggacgaca aatcttgtcc gtgtgaattt gtgaccgaag acctcactcc gggtttgaaa     1740

gtgtctatca gagcggtgtg cgtgatgaga ttcctcgtct ccaagcgtaa attcaaggaa     1800

tccttgcgac cgtatgacgt tatggacgtt atcgaacaat actcagctgg acatttggat     1860

atgctttcgc gtatcaagtc cctccaaagt agagtggacc aaattgttgg cagaggacct     1920

gcaatcaccg acaaggacag aacgaagggt cctgcggaag ccgagctgcc tgaggaccca     1980

tcaatgatgg gtagattggg caaggttgaa aaacaagttt tgagtatgga gaagaaactg     2040

gactttcttg tcaatatcta tatgcaaaga atgggaatcc ctcctacgga gaccgaggcc     2100

tacttcggag ccaaggttaa atgtacaaac aactatttga aagattttct cacccgattt     2160

tttcaggagc ccgagccagc ccctccatac cactcaccag aagactcacg tgaacacgtt     2220

gacagacacg gttgcattgt gaaaattgtt cgttcttcgt cctcgacggg tcagaaaaac     2280

ttctcagcac cacctgctgc ccctcctgtc caatgccctc cgtcaactag ttggcaaccg     2340

caaagtcatc cgcgtcaggg ccatggtacg agtccagtag gcgatcacgg ctcgttggtg     2400

cgaatcccgc ctcctcctgc ccacgagaga tcattgtctg cctacggtgg cggcaatcga     2460

gcatctatgg agttcctgag acaagaagac accccaggat gcagaccgcc agagggtaac     2520

cttcgtgact ctgacacgtc catttcaatc ccttcagttg accacgaaga actcgagaga     2580

tccttcagtg gattttccat ctctcaatct aaagaaaatc tggatgccct caactcatgt     2640

tatgcggcgg tcgcaccgtg tgcaaaggtt cgtccttaca tcgcggaggg agagagtgac     2700

acagacagtg acctgtgcac gccttgcgga ccgccgccac gatcagctac cggagaaggc     2760

cctttcggtg atgtgggatg ggcaggccct cgaaaataa                            2799


<210>  6
<211>  20
<212>  DNA
<213>  C. elegans

<400>  6
ttttgcatcc gaaaaagcgg                                                   20


<210>  7
<211>  501
<212>  DNA
<213>  C. elegans

<400>  7
cttatcattt caatttattt attaatcgat gattgaaagt gaatggatga cggtcatgac       60

cgattatcga ttatcccgaa atagagatgc gcgtaggtca taatgcccag tacgcaaaat      120

gttttatcgg tgtttgcaca gatttcgcaa catctctcat tgaatttcca ttcatcgctt      180

cgtcatctga ccccatttct tattttttca tccttttccc tgttctcatc gttccttact      240

attttcctaa tttcagaaca tcgcgatttt ataatttcgt taaatattcg taatcccgtt      300

atacaaaaat agctaaattt tctagtcgtt ctcgtttttg agagggcact ttagtccgtc      360

atcgtgtcgc ttgtcgtgct caatttttca tgcataaatg ggcgtcgccg tcccccctgt      420

cgttttcttc ctttacctca ctttccagtt ctgaattccg atacgaattt ttaaattttt      480

ctaactcgct tcatttcagg g                                                501


<210>  8
<211>  20
<212>  DNA
<213>  C. elegans

<400>  8
ttttgcatcc gaaaaagcgg                                                   20


<210>  9
<211>  648
<212>  DNA
<213>  C. elegans

<400>  9
cgattactaa cataatatac ctatttctga gcccaacgtc cgctgctttc gggcgcacaa       60

aagatgtaat ccgagatctg cgatttgtac atatttcgga tacattttca atctccattt      120

ccaactcatc ttctaattcg ggacaatgag catcatcatg agcatgtgta cacaaggtag      180

ttcggtcgcc cagttgccga ttacataggc acccggttgc cgagtagacg agttgtaaaa      240

acagggcacc acgagatatt gccgatttcc acataaacta cttattaaag tctggagatt      300

taattcatat gtcaagaaaa atgttcgtga aagcaacaat atatgtacta gaaatcccta      360

agacgacgac tatcgctgac gttacattgc tccaaaagaa tgcaatgaat tgtgattaca      420

ccatgagagt tttcaaaact ttaaacctca aattaatatt tcaacttatt aacctacttc      480

ctattctttt caattcttta tttgtctatc gtctctttat tcccaatgat ctctcttcta      540

agagcttcta ccttatcggc tactgtgtcc aattacccat cgacgctcct ccctcttttg      600

cgcgaaactg ggcggagcct aagatgagat tcagtaaaat aggttctc                   648


<210>  10
<211>  81
<212>  DNA
<213>  C. elegans

<400>  10
gggctacgta atacgactca cttaaggcct taatcccaat aaacctgtat tcctgtgtgt       60

cgtcaagatg gtcttatccg g                                                 81


<210>  11
<211>  61
<212>  DNA
<213>  C. elegans

<400>  11
gccctctaag ataaatgcaa aatcctttca agcattccct gagacttttt tcttggcggc       60

a                                                                       61


<210>  12
<211>  1569
<212>  DNA
<213>  C. elegans

<400>  12
atgaaatcga tcttggatgg acttgcagat actacgttcc gtaccatcac caccgacctc       60

ctctacgtcg gatccaacga catccaatac gaggacatca agggagacat ggcctccaag      120

ctcggatact tcccacaaaa gttcccactc acctccttcc gtggatcccc attccaagag      180

aagatgaccg ccggagacaa cccacaactc gtcccagccg accaagtcaa catcaccgag      240

ttctataata agtccctctc ctccttcaag gtaagtttaa acatatatat actaactaac      300

cctgattatt taaattttca ggagaatgag gagaacatcc aatgcggaga gaacttcatg      360

gacatcgagt gcttcatggt cctcaaccca tcccaacaac tcgccatcgc cgtcctctcc      420

ctcaccctcg gaaccttcac cgtcctcgag aacctcctcg tcctctgcgt catcctccac      480

tcccgttccc tccgttgccg tccatcctac cacttcatcg gatccctcgc cgtcgccgac      540

ctcctcggat ccgtcatctt cgtctactcc ttcatcgact tccacgtctt ccacagaaag      600

gactcccgta acgtcttcct ctttaagctt ggaggagtta ctgcctcctt caccgcttcc      660

gtcggatccc tcttcctcac cgccatcgac cgttacatct ccatccaccg tccactcgcc      720

tacaagcgta tcgtcacccg tccaaaggta agtttaaaag ttcgtactaa ctaaccatac      780

atatttaaat tttcaggccg tcgtcgcctt ctgcctcatg tggaccatcg ccatcgtcat      840

cgccgtcctc ccactcctcg gatggaactg cgagaagctc caatccgtct gctccgacat      900

cttcccacac atcgacgaga cctacctcat gttctggatc ggagtcacct ccgtcctcct      960

cctcttcatc gtctacgcct acatgtacat cctctggaag gcccactccc acgccgtccg     1020

tatgatccaa cgtggaaccc aaaagtccat catcatccac acctccgagg acggaaaggt     1080

ccaagtcacc cgtccagacc aagctagaat ggacatccgt ctcgccaagg taagtttaac     1140

atgattttac taactaacta atctgattta aattttcaga ccctcgtcct catcctcgtc     1200

gtcctcatca tctgctgggg accactcctc gccatcatgg tctacgacgt cttcggaaag     1260

atgaacaagc tcatcaagac cgtcttcgcc ttctgctcca tgctctgcct cctcaactcc     1320

accgtcaacc caatcatcta cgccctccgt tccaaggacc tccgtcacgc cttccgttcc     1380

atgttcccat cctgcgaggg aaccgcccaa ccactcgaca actccatggg agactccgac     1440

tgcctccaca agcacgccaa caacgccgcc tccgtccacc gtgccgccga gtcctgcatc     1500

aagtccaccg tcaagatcgc caaggtcacc atgtccgtct ccaccgacac ctccgccgag     1560

gccctctaa                                                             1569


<210>  13
<211>  472
<212>  PRT
<213>  C. elegans

<400>  13

Met Lys Ser Ile Leu Asp Gly Leu Ala Asp Thr Thr Phe Arg Thr Ile 
1               5                   10                  15      


Thr Thr Asp Leu Leu Tyr Val Gly Ser Asn Asp Ile Gln Tyr Glu Asp 
            20                  25                  30          


Ile Lys Gly Asp Met Ala Ser Lys Leu Gly Tyr Phe Pro Gln Lys Phe 
        35                  40                  45              


Pro Leu Thr Ser Phe Arg Gly Ser Pro Phe Gln Glu Lys Met Thr Ala 
    50                  55                  60                  


Gly Asp Asn Pro Gln Leu Val Pro Ala Asp Gln Val Asn Ile Thr Glu 
65                  70                  75                  80  


Phe Tyr Asn Lys Ser Leu Ser Ser Phe Lys Glu Asn Glu Glu Asn Ile 
                85                  90                  95      


Gln Cys Gly Glu Asn Phe Met Asp Ile Glu Cys Phe Met Val Leu Asn 
            100                 105                 110         


Pro Ser Gln Gln Leu Ala Ile Ala Val Leu Ser Leu Thr Leu Gly Thr 
        115                 120                 125             


Phe Thr Val Leu Glu Asn Leu Leu Val Leu Cys Val Ile Leu His Ser 
    130                 135                 140                 


Arg Ser Leu Arg Cys Arg Pro Ser Tyr His Phe Ile Gly Ser Leu Ala 
145                 150                 155                 160 


Val Ala Asp Leu Leu Gly Ser Val Ile Phe Val Tyr Ser Phe Ile Asp 
                165                 170                 175     


Phe His Val Phe His Arg Lys Asp Ser Arg Asn Val Phe Leu Phe Lys 
            180                 185                 190         


Leu Gly Gly Val Thr Ala Ser Phe Thr Ala Ser Val Gly Ser Leu Phe 
        195                 200                 205             


Leu Thr Ala Ile Asp Arg Tyr Ile Ser Ile His Arg Pro Leu Ala Tyr 
    210                 215                 220                 


Lys Arg Ile Val Thr Arg Pro Lys Ala Val Val Ala Phe Cys Leu Met 
225                 230                 235                 240 


Trp Thr Ile Ala Ile Val Ile Ala Val Leu Pro Leu Leu Gly Trp Asn 
                245                 250                 255     


Cys Glu Lys Leu Gln Ser Val Cys Ser Asp Ile Phe Pro His Ile Asp 
            260                 265                 270         


Glu Thr Tyr Leu Met Phe Trp Ile Gly Val Thr Ser Val Leu Leu Leu 
        275                 280                 285             


Phe Ile Val Tyr Ala Tyr Met Tyr Ile Leu Trp Lys Ala His Ser His 
    290                 295                 300                 


Ala Val Arg Met Ile Gln Arg Gly Thr Gln Lys Ser Ile Ile Ile His 
305                 310                 315                 320 


Thr Ser Glu Asp Gly Lys Val Gln Val Thr Arg Pro Asp Gln Ala Arg 
                325                 330                 335     


Met Asp Ile Arg Leu Ala Lys Thr Leu Val Leu Ile Leu Val Val Leu 
            340                 345                 350         


Ile Ile Cys Trp Gly Pro Leu Leu Ala Ile Met Val Tyr Asp Val Phe 
        355                 360                 365             


Gly Lys Met Asn Lys Leu Ile Lys Thr Val Phe Ala Phe Cys Ser Met 
    370                 375                 380                 


Leu Cys Leu Leu Asn Ser Thr Val Asn Pro Ile Ile Tyr Ala Leu Arg 
385                 390                 395                 400 


Ser Lys Asp Leu Arg His Ala Phe Arg Ser Met Phe Pro Ser Cys Glu 
                405                 410                 415     


Gly Thr Ala Gln Pro Leu Asp Asn Ser Met Gly Asp Ser Asp Cys Leu 
            420                 425                 430         


His Lys His Ala Asn Asn Ala Ala Ser Val His Arg Ala Ala Glu Ser 
        435                 440                 445             


Cys Ile Lys Ser Thr Val Lys Ile Ala Lys Val Thr Met Ser Val Ser 
    450                 455                 460                 


Thr Asp Thr Ser Ala Glu Ala Leu 
465                 470         


<210>  14
<211>  1227
<212>  DNA
<213>  C. elegans

<400>  14
atggaggaat gttgggttac agagatagca aatggtagca aggacggact cgattccaac       60

cctatgaaag actacatgat cctctccgga ccacaaaaga ccgccgttgc cgttctctgc      120

accctcctcg gactcctctc tgctcttgag aacgtcgccg tcctctacct catcctctcc      180

tcccaccaac tccgtcgtaa gccatcctac ctcttcatcg gatccctcgc cggagccgac      240

ttcctcgcct ccgtcgtctt cgcctgctcc ttcgtcaact tccacgtctt ccacggagtc      300

gactccaagg taagtttaaa catatatata ctaactaacc ctgattataa attttcaggc      360

cgtcttcctc ctcaagatcg gatccgtcac catgaccttc accgcctccg tcggatccct      420

cctcctcacc gccatcgacc gttacctctg cctccgttac ccaccatcct acaaggccct      480

cctcacccgt ggacgtgccc tcgtcaccct cggaatcatg tgggtcctct ccgccctcgt      540

ctcctacctc ccactcatgg gatggacctg ctgcccacgt ccatgctccg agctcttccc      600

actcatccca aacgactacc tcctctcctg gctcctcttc atcgccttcc tcttctccgg      660

aatcatctac acctacggac acgtcctctg gaaggtaagt tcctccacta gaaatatcag      720

gtgctataat tgtgttcagg cccaccaaca cgtcgcctcc ctctccggac accaagaccg      780

tcaagtccca ggaatggccc gtatgcgtct cgacgtccgt ctcgccaaga ccctcggact      840

cgtcctcgcc gtcctcctca tctgctggtt cccagtcctc gccctcatgg cccactccct      900

cgccaccacc ctctccgacc aagtcaaggt aagtttaaca tgattttact aactaactaa      960

tctgatttaa attttcagaa ggccttcgcc ttctgctcca tgctctgcct catcaactcc     1020

atggtcaacc cagtcatcta cgccctccgt tccggagaga tccgttcctc cgcccaccac     1080

tgcctcgccc actggaagaa gtgcgtccgt ggactcggat ccgaggccaa ggaggaggcc     1140

ccacgttcct ccgtcaccga gaccgaggcc gacggaaaga tcaccccatg gccagactcc     1200

cgtgacctcg acctctccga ctgctaa                                         1227


<210>  15
<211>  360
<212>  PRT
<213>  C. elegans

<400>  15

Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly 
1               5                   10                  15      


Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln 
            20                  25                  30          


Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala 
        35                  40                  45              


Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu 
    50                  55                  60                  


Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp 
65                  70                  75                  80  


Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val 
                85                  90                  95      


Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser 
            100                 105                 110         


Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala 
        115                 120                 125             


Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu 
    130                 135                 140                 


Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu 
145                 150                 155                 160 


Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro 
                165                 170                 175     


Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu 
            180                 185                 190         


Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr 
        195                 200                 205             


Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser 
    210                 215                 220                 


Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp 
225                 230                 235                 240 


Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile 
                245                 250                 255     


Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr 
            260                 265                 270         


Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys 
        275                 280                 285             


Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly 
    290                 295                 300                 


Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys 
305                 310                 315                 320 


Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser 
                325                 330                 335     


Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser 
            340                 345                 350         


Arg Asp Leu Asp Leu Ser Asp Cys 
        355                 360 


<210>  16
<211>  1641
<212>  DNA
<213>  C. elegans

<400>  16
atggcctcca tgctcctcgc ccaacgtctc gcctgctcct tccaacactc ctaccgtctc       60

ctcgtcccag gatcccgtca catctcccaa gccgccgcca aggtcgacgt cgagttcgac      120

tacgacggac cactcatgaa gaccgaggtc ccaggaccac gttcccaaga gctcatgaag      180

caactcaaca tcatccaaaa cgccgaggcc gtccacttct tctgcaacta cgaggagtcc      240

cgtggaaact acctcgtcga cgtcgacgga aaccgtatgc tcgacctcta ctcccaaatc      300

tcctccgtcc caatcggata ctcccaccca gccctcctca agctcatcca acaaccacaa      360

aacgcctcca tgttcgtcaa ccgtccagcc ctcggaatcc tcccaccaga gaacttcgtc      420

gagaagctcc gtcaatccct cctctccgtc gccccaaagg tacttgagat ccttaaacgc      480

agtcgaaaat tggtaatttt acagggaatg tcccaactca tcaccatggc ctgcggatcc      540

tgctccaacg agaacgccct caagaccatc ttcatgtggt accgttccaa ggagcgtgga      600

caacgtggat tctcccaaga ggagctcgag acctgcatga tcaaccaagc cccaggatgc      660

ccagactact ccatcctctc cttcatggga gccttccacg gacgtaccat gggatgcctc      720

gccaccaccc actccaaggc catccacaag atcgacatcc catccttcga ctggccaatc      780

gccccattcc cacgtctcaa gtacccactc gaggagttcg tcaaggtaag ttcctccact      840

agaaatatca ggtgctataa ttgtgttcag gagaaccaac aagaggaggc ccgttgcctc      900

gaggaggtcg aggacctcat cgtcaagtac cgtaagaaga agaagaccgt cgccggaatc      960

atcgtcgagc caatccaatc cgagggagga gacaaccacg cctccgacga cttcttccgt     1020

aagctccgtg acatcgcccg taagcacgga tgcgccttcc tcgtcgacga ggtccaaacc     1080

ggaggaggat gcaccggaaa gttctgggcc cacgagcact ggggactcga cgacccagcc     1140

gacgtcatga ccttctccaa gaagatgatg accggaggat tcttccacaa ggtgagttat     1200

tataattttt ttgatcacaa cgattatttt aattttcagg aggagttccg tccaaacgcc     1260

ccataccgta tcttcaacac ctggctcgga gacccatcca agaacctcct cctcgccgag     1320

gtcatcaaca tcatcaagcg tgaggacctc ctcaacaacg ccgcccacgc cggaaaggcc     1380

ctcctcaccg gactcctcga cctccaagcc cgttacccac aattcatctc ccgtgtccgt     1440

ggacgtggaa ccttctgctc cttcgacacc ccagacgact ccatccgtaa caagctcatc     1500

ctcatcgccc gtaacaaggg agtcgtcctc ggaggatgcg gagacaagtc catccgtttc     1560

cgtccaaccc tcgtcttccg tgaccaccac gcccacctct tcctcaacat cttctccgac     1620

atcctcgccg acttcaagta a                                               1641


<210>  17
<211>  20
<212>  DNA
<213>  zebrafish

<400>  17
tagtggacca gctcagcatg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  zebrafish

<400>  18
gatatcagtc attttgcagc                                                   20


<210>  19
<211>  50
<212>  DNA
<213>  zebrafish

<400>  19
cggtgcgggt gccagggcgt gcccttgggc tccccgggcg cgtactccac                  50


