                         SEQUENCE LISTING

<110>  Entrada Therapeutics, Inc.
 
<120>  COMPOSITIONS FOR DELIVERY OF ANTISENSE COMPOUNDS

<130>  CYPT-024/03WO 329395-2162

<140>  PCT/US2020/066459
<141>  2020-12-21

<150>  US 63/069,984
<151>  2020-08-25

<150>  US 63/052,286
<151>  2020-07-15

<150>  US 63/036,240
<151>  2020-06-08

<150>  US 62/950,639
<151>  2019-12-19

<160>  272   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  1

Phe Xaa Arg Arg Arg 
1               5   


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  2

Phe Xaa Arg Arg Arg Cys 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Selenocysteine

<400>  3

Phe Xaa Arg Arg Arg Xaa 
1               5       


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-2-naphthylalanine

<400>  4

Arg Arg Arg Xaa Phe 
1               5   


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-2-naphthylalanine

<400>  5

Arg Arg Arg Arg Xaa Phe 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  6

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  7

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  8

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  9

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  10

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-2-naphthylalanine

<400>  11

Arg Arg Phe Arg Xaa Arg 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  L-2-naphthylalanine

<400>  12

Phe Arg Arg Arg Arg Xaa 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-2-naphthylalanine

<400>  13

Arg Arg Phe Arg Xaa Arg 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-2-naphthylalanine

<400>  14

Arg Arg Xaa Phe Arg Arg 
1               5       


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Cys Arg Arg Arg Arg Phe Trp 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-amino acid

<400>  16

Phe Phe Xaa Arg Arg Arg Arg 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-2-naphthylalanine

<400>  17

Phe Phe Xaa Arg Arg Arg Arg 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  L-2-naphthylalanine

<400>  18

Arg Phe Arg Phe Arg Xaa Arg 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Selenocysteine

<400>  19

Xaa Arg Arg Arg Arg Phe Trp 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Cys Arg Arg Arg Arg Phe Trp 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  21

Phe Xaa Arg Arg Arg Arg Gln Lys 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  22

Phe Xaa Arg Arg Arg Arg Gln Cys 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  23

Phe Xaa Arg Arg Arg Arg Arg Gln 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  24

Phe Xaa Arg Arg Arg Arg Arg Gln 
1               5               


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-norleucine

<400>  25

Arg Arg Arg Arg Xaa Phe Asp Xaa Cys 
1               5                   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  26

Phe Xaa Arg Arg Arg 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Phe Trp Arg Arg Arg 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-2-naphthylalanine

<400>  28

Arg Arg Arg Xaa Phe 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Arg Arg Arg Trp Phe 
1               5   


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  30

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Phe Phe Arg Arg Arg 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  32

Phe Phe Arg Arg Arg 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<400>  33

Phe Phe Arg Arg Arg 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Phe Arg Phe Arg Arg 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Phe Arg Arg Phe Arg 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Phe Arg Arg Arg Phe 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  37

Gly Xaa Arg Arg Arg 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Phe Phe Phe Arg Ala 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Phe Phe Phe Arg Arg 
1               5   


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Phe Phe Arg Arg Arg Arg 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Phe Arg Arg Phe Arg Arg 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Phe Arg Arg Arg Phe Arg 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Arg Phe Phe Arg Arg Arg 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Arg Phe Arg Arg Phe Arg 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Phe Arg Phe Arg Arg Arg 
1               5       


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Phe Phe Phe Arg Arg Arg 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Phe Phe Arg Arg Arg Phe 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Phe Arg Phe Phe Arg Arg 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Arg Arg Phe Phe Phe Arg 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Phe Phe Arg Phe Arg Arg 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Phe Phe Arg Arg Phe Arg 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Phe Arg Arg Phe Phe Arg 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Phe Arg Arg Phe Arg Phe 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Phe Arg Phe Arg Phe Arg 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Arg Phe Phe Arg Phe Arg 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  56

Gly Xaa Arg Arg Arg Arg 
1               5       


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Phe Phe Phe Arg Arg Arg Arg 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Arg Phe Phe Arg Arg Arg Arg 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Arg Arg Phe Phe Arg Arg Arg 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Arg Phe Phe Phe Arg Arg Arg 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Arg Arg Phe Phe Phe Arg Arg 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Phe Phe Arg Arg Phe Arg Arg 
1               5           


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Phe Phe Arg Arg Arg Arg Phe 
1               5           


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Phe Arg Arg Phe Phe Arg Arg 
1               5           


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Phe Phe Phe Arg Arg Arg Arg Arg 
1               5               


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Phe Phe Phe Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  67

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  L-4-fluorophenylalanine

<400>  68

Xaa Xaa Arg Arg Arg Arg 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  69

Phe Phe Phe Arg Arg Arg 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (3)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  70

Phe Phe Phe Arg Arg Arg 
1               5       


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  71

Phe Phe Phe Arg Arg Arg 
1               5       


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  72

Phe Phe Phe Arg Arg Arg 
1               5       


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  73

Phe Phe Xaa Arg Arg Arg 
1               5       


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  74

Phe Xaa Phe Arg Arg Arg 
1               5       


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  75

Xaa Phe Phe Arg Arg Arg 
1               5       


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  76

Phe Xaa Arg Arg Arg 
1               5   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  77

Phe Xaa Arg Arg Arg 
1               5   


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-amino acid

<400>  78

Lys Phe Phe Arg Arg Arg Arg Asp 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-amino acid

<400>  79

Xaa Phe Phe Arg Arg Arg Arg Asp 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  DISULFID
<222>  (1)..(8)
<223>  disulfide bond

<400>  80

Cys Trp Trp Arg Arg Arg Arg Cys 
1               5               


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  DISULFID
<222>  (1)..(9)
<223>  disulfide bond

<400>  81

Cys Trp Trp Trp Arg Arg Arg Arg Cys 
1               5                   


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  DISULFID
<222>  (1)..(8)
<223>  disulfide bond

<400>  82

Cys Phe Trp Arg Arg Arg Arg Cys 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  DISULFID
<222>  (1)..(8)
<223>  disulfide bond

<400>  83

Cys Trp Trp Trp Arg Arg Arg Cys 
1               5               


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(7)
<223>  D-amino acid

<400>  84

Xaa Xaa Arg Glu Arg Arg Glu 
1               5           


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(7)
<223>  D-amino acid

<400>  85

Xaa Xaa Arg Arg Arg Arg Glu 
1               5           


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(7)
<223>  D-amino acid

<400>  86

Xaa Xaa Xaa Arg Arg Arg Glu 
1               5           


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(6)
<223>  D-amino acid

<400>  87

Xaa Xaa Xaa Arg Arg Arg Glu 
1               5           


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(7)
<223>  D-amino acid

<400>  88

Xaa Xaa Phe Arg Arg Arg Glu 
1               5           


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(6)
<223>  D-amino acid

<400>  89

Xaa Xaa Phe Arg Arg Arg Glu 
1               5           


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(7)
<223>  D-amino acid

<400>  90

Xaa Xaa Phe Arg Arg Arg Glu 
1               5           


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(6)
<223>  D-amino acid

<400>  91

Xaa Xaa Phe Arg Arg Arg Glu 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(6)
<223>  D-amino acid

<400>  92

Xaa Xaa Xaa Arg Arg Arg Glu 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(7)
<223>  D-amino acid

<400>  93

Xaa Xaa Xaa Arg Arg Arg Glu 
1               5           


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Arg is modified with pimelic acid

<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Cyclization between Arg is modified with pimelic acid and Arg is 
       modified with lysine peptoid residue

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Arg is modified with lysine peptoid residue

<400>  94

Arg Gln Arg Arg Gly Arg Arg Arg 
1               5               


<210>  95
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DISULFID
<222>  (2)..(19)
<223>  Cys residues jopined by disulfide bond

<400>  95

Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly Pro Pro 
1               5                   10                  15      


Val Ser Cys 
            


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  Cyclization between Lys and Glu

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D-amino acid

<400>  96

Lys Arg Arg Arg Gly Arg Lys Lys Arg Arg Glu 
1               5                   10      


<210>  97
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Cyclization between Lys and Glu

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D-amino acid

<400>  97

Lys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Glu 
1               5                   10          


<210>  98
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D-amino acid

<400>  98

Arg Val Arg Thr Arg Gly Lys Arg Arg Ile Arg Arg Pro Pro 
1               5                   10                  


<210>  99
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D-amino acid

<400>  99

Arg Thr Arg Thr Arg Gly Lys Arg Arg Ile Arg Val Pro Pro 
1               5                   10                  


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  100

Trp Arg Trp Arg Trp Arg Trp Arg 
1               5               


<210>  101
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DISULFID
<222>  (4)..(21)
<223>  Cys residues jopined by disulfide bond

<220>
<221>  DISULFID
<222>  (11)..(23)
<223>  Cys residues jopined by disulfide bond

<220>
<221>  DISULFID
<222>  (17)..(29)
<223>  Cys residues jopined by disulfide bond

<400>  101

Gly Gly Val Cys Pro Lys Ile Leu Lys Lys Cys Arg Arg Asp Ser Asp 
1               5                   10                  15      


Cys Pro Gly Ala Cys Ile Cys Arg Gly Asn Gly Tyr Cys Gly Ser Gly 
            20                  25                  30          


Ser Asp 
        


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Macrocyclization by multicomponent reaction with aziridine 
       aldehyde and isocyanide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-3-cyclohexyl-alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-cyclohexylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  L-cyclohexylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-cyclohexylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D-amino acid

<400>  102

Pro Xaa Arg Xaa Arg Xaa Arg Xaa Arg Gly 
1               5                   10  


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ser is modified with trimesic acid

<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  N-terminal amine and side chains of two L-2,3-diaminopropionic 
       acid residues bicyclized with trimesic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-4-(phosphonodifluoromethyl)phenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  L-naphthylalanine

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  L-2,3-diaminopropionic acid

<400>  103

Ser Val Pro Xaa His Xaa Phe Xaa Arg Arg Arg Arg Xaa 
1               5                   10              


<210>  104
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-alanine is modified with trimesic acid

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  N-terminal amine and side chains of two L-2,3-diaminopropionic 
       acid residues bicyclized with trimesic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  sarcosine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-phosphothreonine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-homoproline

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  L-naphthylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D-alanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  L-naphthylalanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  L-2,3-diaminopropionic acid

<400>  104

Ala Xaa Asp Xaa Xaa Xaa Arg Ala Xaa Xaa Phe Xaa Arg Arg Arg Arg 
1               5                   10                  15      


Xaa 
    


<210>  105
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Three Cys side chains bicyclized with tris(bromomethyl)benzene

<400>  105

Cys Arg Arg Ser Arg Arg Gly Cys Gly Arg Arg Ser Arg Arg Cys Gly 
1               5                   10                  15      


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  linked by dodecanoyl moiety

<400>  106

Lys Arg Arg Arg Arg 
1               5   


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  107

Leu Lys Lys Leu Cys Lys Leu Leu Lys Lys Leu Cys Lys Leu Ala Gly 
1               5                   10                  15      


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Cyclization between Lys and Glu

<400>  108

Arg Arg Arg Arg Lys Arg Arg Arg Glu 
1               5                   


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(9)
<223>  Cyclization between Lys and Glu

<400>  109

Arg Arg Arg Lys Arg Arg Arg Arg Glu 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(9)
<223>  Cyclization between Lys and Glu

<400>  110

Arg Arg Lys Arg Arg Arg Arg Arg Glu 
1               5                   


<210>  111
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(9)
<223>  Cyclization between Lys and Glu

<400>  111

Arg Lys Arg Arg Arg Arg Arg Arg Glu 
1               5                   


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  112

Cys Arg Cys Arg Cys Arg Cys Arg 
1               5               


<210>  113
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L-propargylglycine

<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Cyclization by the click reaction between L-propargylglycine and 
       L-6-Azido-2-amino-hexanoic

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  L-6-Azido-2-amino-hexanoic

<400>  113

Xaa Leu Arg Lys Arg Leu Arg Lys Phe Arg Asn Xaa 
1               5                   10          


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (2)..(4)
<223>  L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(8)
<223>  L-2,3-diaminopropionic acid

<400>  114

Thr Xaa Xaa Xaa Phe Leu Xaa Xaa Thr 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-amino-3-guanidinylpropionic acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  L-2-amino-3-guanidinylpropionic acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(8)
<223>  L-2-amino-3-guanidinylpropionic acid

<400>  115

Thr Xaa Xaa Xaa Phe Leu Xaa Xaa Thr 
1               5                   


<210>  116
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  116

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-amino acid

<400>  117

Phe Phe Xaa Arg Arg Arg Arg 
1               5           


<210>  118
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  118

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  119

Phe Xaa Arg Arg Arg Arg Arg 
1               5           


<210>  120
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  120

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  121
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<400>  121

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  122

Phe Xaa Arg Arg Arg Arg Arg 
1               5           


<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-2-naphthylalanine

<400>  123

Arg Arg Phe Arg Xaa Arg Gln 
1               5           


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-2-naphthylalanine

<400>  124

Phe Phe Xaa Arg Arg Arg Arg 
1               5           


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  L-2-naphthylalanine

<400>  125

Arg Phe Arg Phe Arg Xaa Arg 
1               5           


<210>  126
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  126

Phe Xaa Arg Arg Arg 
1               5   


<210>  127
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  L-2-naphthylalanine

<400>  127

Phe Arg Arg Arg Arg Xaa 
1               5       


<210>  128
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  L-2-naphthylalanine

<400>  128

Arg Arg Phe Arg Xaa Arg 
1               5       


<210>  129
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-2-naphthylalanine

<400>  129

Arg Arg Xaa Phe Arg Arg 
1               5       


<210>  130
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (3)..(4)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-amino acid

<400>  130

Phe Xaa Phe Arg Arg Arg 
1               5       


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  131

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  132
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  132

Asn Leu Ser Lys Arg Pro Ala Ala Ile Lys Lys Ala Gly Gln Ala Lys 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  133

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  134

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Phe 
1               5                   10      


<210>  135
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  135

Arg Met Arg Lys Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu Arg 
1               5                   10                  15      


Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys Asp 
            20                  25                  30          


Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40      


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  136

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  137

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  138

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  139

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  140
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  140

Asp Arg Leu Arg Arg 
1               5   


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  141

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  142

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  143
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  143

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  144
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  144

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nuclear localization sequence

<400>  145

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  cyclic peptide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  L-2-naphthylalanine

<400>  146

Phe Xaa Arg Arg Arg Arg Gln 
1               5           


<210>  147
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  immunostimulatory nucleic acid

<400>  147
taacgttgag gggcat                                                       16


<210>  148
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound phosphorodiamidate morpholino oligomer (PMO) 
       with a C6-thiol 5' modification


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  C6-thiol 5' modification

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  148
gctattacct taacccag                                                     18


<210>  149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  L-2-naphthylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  gamma-glutamate

<220>
<221>  MOD_RES
<222>  (9)..(10)
<223>  beta-alanine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  modiified with maleimide

<400>  149

Phe Phe Xaa Arg Arg Arg Arg Xaa Xaa Xaa Lys 
1               5                   10      


<210>  150
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT-PCR primer

<400>  150
cgtaaacggc cacaagttca gcg                                               23


<210>  151
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RT-PCR primer

<400>  151
gtggtgcaga tgaacttcag ggtc                                              24


<210>  152
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound

<400>  152
gctattacct taaccca                                                      17


<210>  153
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  modified_base
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  153
gtaactgtat ttggtacttc c                                                 21


<210>  154
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  conjugated to CP12 peptide

<400>  154
cttcttcttc ttcttcttct tcttc                                             25


<210>  155
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  conjugated to CP12 peptide

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by phosphorothioate bonds

<400>  155
cttcttcttc ttcttctt                                                     18


<210>  156
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  conjugated to CP12 peptide

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (6)..(7)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (18)..(19)
<223>  locked nucleic acid

<400>  156
tcttcttctt cttcttctt                                                    19


<210>  157
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  conjugated to CP12 peptide

<400>  157
gctattacct taacccag                                                     18


<210>  158
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  conjugated to CP12 peptide and lipid group

<400>  158
gctattacct taacccag                                                     18


<210>  159
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  conjugated to CP1212 peptide

<400>  159
gctattacct taacccag                                                     18


<210>  160
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  conjugated to Pip peptide

<400>  160
gctattacct taacccag                                                     18


<210>  161
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(24)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  conjugated to CP12 peptide

<400>  161
gggcatttta atatatctct gaac                                              24


<210>  162
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(24)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  conjugated to CP12 peptide

<400>  162
ggccaaacct cggcttacct gaaa                                              24


<210>  163
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(24)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  conjugated to CP12 peptide and lipid group

<400>  163
ggccaaacct cggcttacct gaaa                                              24


<210>  164
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  conjugated to CP12 peptide

<400>  164
gtaactgtat ttggtacttc c                                                 21


<210>  165
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  165
ccaactgtcc tcaaaagcag gaata                                             25


<210>  166
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense compound


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  166
ccgggtctgc cgcccgctcc gccct                                             25


<210>  167
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  5-methyl cytosine

<400>  167
ttcttcttct tcttcttc                                                     18


<210>  168
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  5-methyl cytosine

<400>  168
cttcttcttc ttcttcttct                                                   20


<210>  169
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  5-methyl cytosine

<400>  169
tcttcttctt cttcttcttc                                                   20


<210>  170
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(19)
<223>  2'-fluoro ribonucleotides

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  linked by phosphorothioate bonds

<400>  170
gaagaagaag aagaagaag                                                    19


<210>  171
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(19)
<223>  2'-fluoro ribonucleotides

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  linked by phosphorothioate bonds

<400>  171
cuucuucuuc uucuucuuc                                                    19


<210>  172
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked by phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  conjugated to CPP12

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  amidated

<220>
<221>  modified_base
<222>  (1)..(19)
<223>  2'-fluoro ribonucleotides

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  linked by phosphorothioate bonds

<400>  172
gaagaagaag aagaagaag                                                    19


<210>  173
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(19)
<223>  2'-fluoro ribonucleotides

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  linked by phosphorothioate bonds

<400>  173
cuucuucuuc uucuucuuc                                                    19


<210>  174
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  2'-fluoro ribonucleotides

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  amidated

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  conjugated to CPP12

<400>  174
gaagaagaag aagaagaag                                                    19


<210>  175
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(19)
<223>  2'-fluoro ribonucleotides

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  linked by phosphorothioate bonds

<400>  175
cuucuucuuc uucuucuuc                                                    19


<210>  176
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  ribonucleotides

<400>  176
gaagaagaag aagaagaagt t                                                 21


<210>  177
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  ribonucleotides

<400>  177
cuucuucuuc uucuucuuct t                                                 21


<210>  178
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  ribonucleotides

<400>  178
gcuauaccag cgucgucaut t                                                 21


<210>  179
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  ribonucleotides

<400>  179
atgacgacgc tggtatagct t                                                 21


<210>  180
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  ribonucleotides

<400>  180
gagugucuau uugaugaaut t                                                 21


<210>  181
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  ribonucleotides

<400>  181
auucaucaaa uagacacuct t                                                 21


<210>  182
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(17)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  5-methyl cytosine

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  5-methyl cytosine

<400>  182
cctcaaaagc aggaaua                                                      17


<210>  183
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(15)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  5-methyl cytosine

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  5-methyl cytosine

<400>  183
ccgggtctgc cgccc                                                        15


<210>  184
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(17)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  184
cctcaaaagc aggaata                                                      17


<210>  185
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  185
ccgggtctgc cgccc                                                        15


<210>  186
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  186
ccaactgtcc tcaaaagcag gaata                                             25


<210>  187
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  187
ccgggtctgc cgcccgctcc gccct                                             25


<210>  188
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  188
cttcttcttc ttcttcttct tcttc                                             25


<210>  189
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by phosphorothioate bonds

<400>  189
cttcttcttc ttcttctt                                                     18


<210>  190
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (6)..(7)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  locked nucleic acid

<220>
<221>  modified_base
<222>  (18)..(19)
<223>  locked nucleic acid

<400>  190
tcttcttctt cttcttctt                                                    19


<210>  191
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<400>  191
cttcttcttc ttcttcttct                                                   20


<210>  192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<400>  192
tcttcttctt cttcttcttc                                                   20


<210>  193
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  2'-O-MOE ribonucleotides

<400>  193
cttcttcttc ttcttctt                                                     18


<210>  194
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  modifed with an alkyne moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine moiety

<400>  194
acagacaata aataccgagg                                                   20


<210>  195
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  modified with a cycloctyne moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine moiety

<400>  195
acagacaata aataccgagg                                                   20


<210>  196
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine moiety

<400>  196
acagacaata aataccgagg                                                   20


<210>  197
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  modified with a cyclooctyne moiety

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  S-constrained ethyl motif backboned residues

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  S-constrained ethyl motif backboned residues

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  modified with a primary amine moiety

<400>  197
acaataaata ccgagg                                                       16


<210>  198
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  modified with a cyclooctyne moiety

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  S-constrained ethyl motif backboned residues

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  S-constrained ethyl motif backboned residues

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  conjugated to CP12 peptide

<400>  198
acaataaata ccgagg                                                       16


<210>  199
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine moiety

<400>  199
cggagcggtt gtgaactggc                                                   20


<210>  200
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  modified with an alkyne moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine moiety

<400>  200
cggagcggtg tgaactggca                                                   20


<210>  201
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<400>  201
acagacaata aataccgagg                                                   20


<210>  202
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  modified with a alkyne moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  conjugated to a CPP12 peptide through a PEG12 moiety

<400>  202
acagacaata aataccgagg                                                   20


<210>  203
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  conjugated to a CPP12 peptide through a Peg12-Lys-click moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<400>  203
acagacaata aataccgagg                                                   20


<210>  204
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  conjugated the a CPP12 peptide through a PEG12-click moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<400>  204
acagacaata aataccgagg                                                   20


<210>  205
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  conjugated to a aCPP12-K(CPP12) peptide through a PEG12-K-click 
       moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine moiety

<400>  205
acagacaata aataccgagg                                                   20


<210>  206
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  conjugated to Ac-NLS-Lys(CPP12) peptide through a PEG12-K-click 
       moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<400>  206
acagacaata aataccgagg                                                   20


<210>  207
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine + SMCC moiety

<400>  207
acagacaata aataccgagg                                                   20


<210>  208
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  amidated

<400>  208
cagcagcagc agcagcagca g                                                 21


<210>  209
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  conjugated to CP12 peptides

<400>  209
cagcagcagc agcagcagca g                                                 21


<210>  210
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  modified with an alkyne moiety

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine moiety

<400>  210
acagacaata aataccgagg                                                   20


<210>  211
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  linked by phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2'-O-MOE ribonucleotides

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  modified with a primary amine moiety

<400>  211
cggagcggtt gtgaactggc                                                   20


<210>  212
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  212
ccataataaa gggctcag                                                     18


<210>  213
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  213
cagctggagt ttatcttttg                                                   20


<210>  214
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  214
ggccaaacct cggcttacct gaaa                                              24


<210>  215
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  exemplary RNA sequence

<400>  215
aagaagaaga agaagaagaa                                                   20


<210>  216
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  exemplary RNA sequence

<400>  216
aagaagaaga agaagaagaa gaag                                              24


<210>  217
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be conjugated to a chemical moiety

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  May be conjugated to a chemical moiety

<400>  217
gctattacct taaccca                                                      17


<210>  218
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be conjugated to a chemical moiety

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  May be conjugated to a chemical moiety

<400>  218
ggccaaacct cggcttacct gaaa                                              24


<210>  219
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be conjugated to a chemical moiety

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  May be conjugated to a chemical moiety

<400>  219
gtaactgtat ttggtacttc                                                   20


<210>  220
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be conjugated to a chemical moiety

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  May be conjugated to a chemical moiety

<400>  220
ctgtatttgg tact                                                         14


<210>  221
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  221
gctattacct taacccag                                                     18


<210>  222
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a -C6-NH2 moeity

<400>  222
gctattacct taacccag                                                     18


<210>  223
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a cyclooctyne moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  223
gctattacct taacccag                                                     18


<210>  224
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-PEG12 moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  224
gctattacct taacccag                                                     18


<210>  225
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a CPP12-PEG12-TFP moeity

<400>  225
gctattacct taacccag                                                     18


<210>  226
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a CPP1212-TFP moeity

<400>  226
gctattacct taacccag                                                     18


<210>  227
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-(bidentate-no linker)-PEG12 moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  227
gctattacct taacccag                                                     18


<210>  228
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-(bidentate-PEG4)-PEG12 moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  228
gctattacct taacccag                                                     18


<210>  229
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-(bidentate-PEG12)-PEG12 moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  229
gctattacct taacccag                                                     18


<210>  230
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-(tridentate-no linker)-PEG12 moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  230
gctattacct taacccag                                                     18


<210>  231
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-(tridentate-PEG4)-PEG12 moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  231
gctattacct taacccag                                                     18


<210>  232
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-(tridentate-PEG12)-PEG12 moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  232
gctattacct taacccag                                                     18


<210>  233
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a NLS-ss-CPP12 moeity

<400>  233
gctattacct taacccag                                                     18


<210>  234
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a Ac-NLS-Lys(CPP12)-PEG12-K(N3) moeity

<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a Lissamine Rho moeity

<400>  234
gctattacct taacccag                                                     18


<210>  235
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a click-K-PEG12-Lys(CPP12)-NLS-Ac moeity

<400>  235
gctattacct taacccag                                                     18


<210>  236
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  modified with a click-Lys(N3)-miniPEG-NLS-ss-PEG12-CPP12 moeity

<400>  236
gctattacct taacccag                                                     18


<210>  237
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  237
ggccaaacct cggcttacct gaaat                                             25


<210>  238
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a C3-NH2 moiety

<400>  238
ggccaaacct cggcttacct gaaat                                             25


<210>  239
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a cyclooctyne moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  239
ggccaaacct cggcttacct gaaat                                             25


<210>  240
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a NH2-C3 moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a C3-NH2 moiety

<400>  240
ggccaaacct cggcttacct gaaat                                             25


<210>  241
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a C4-cyclooctyne moiety

<400>  241
ggccaaacct cggcttacct gaaat                                             25


<210>  242
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-PEG12-ValCitPABC moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  242
ggccaaacct cggcttacct gaaat                                             25


<210>  243
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-PEG12-NH moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a NH-PEG12-CPP12 moiety

<400>  243
ggccaaacct cggcttacct gaaat                                             25


<210>  244
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a C3-NH-PEG12-CPP12 moiety

<400>  244
ggccaaacct cggcttacct gaaat                                             25


<210>  245
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-PEG12-Cys-ss-Cys-Lys(N3)-cyclooctyne moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  245
ggccaaacct cggcttacct gaaat                                             25


<210>  246
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-PEG12-Lys(N3)-cyclooctyne moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  246
ggccaaacct cggcttacct gaaat                                             25


<210>  247
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-PEG12-Prodisulfide moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  247
ggccaaacct cggcttacct gaaat                                             25


<210>  248
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-PEG24 moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  248
ggccaaacct cggcttacct gaaat                                             25


<210>  249
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a C3NH-C6-CPP12 moiety

<400>  249
ggccaaacct cggcttacct gaaat                                             25


<210>  250
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-(bidentate-no linker)-PEG12 moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  250
ggccaaacct cggcttacct gaaat                                             25


<210>  251
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a CPP12-(bidentate-PEG12)-PEG12 moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  251
ggccaaacct cggcttacct gaaat                                             25


<210>  252
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a C3-NH-CPP1212 moiety

<400>  252
ggccaaacct cggcttacct gaaat                                             25


<210>  253
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a T9-PEG12-CPP12-PEG12 moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  253
ggccaaacct cggcttacct gaaat                                             25


<210>  254
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a Ac-MSP-PEG12-Lys(CPP12-PEG12)-K(N3) moiety

<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<400>  254
ggccaaacct cggcttacct gaaat                                             25


<210>  255
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a C3NH-PEG4-BCN+Lys(N3)-miniPEG-NLS-ss-bA-bA-CPP12 
       moiety

<400>  255
ggccaaacct cggcttacct gaaat                                             25


<210>  256
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a C3NH-PEG4-BCN+Ac-NLS-Lys(CPP12)-PEG12-K(N3) 
       moiety

<400>  256
ggccaaacct cggcttacct gaaat                                             25


<210>  257
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(25)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a click-K-PEG12-Lys(CPP12)-NLS-Ac moiety

<400>  257
ggccaaacct cggcttacct gaaat                                             25


<210>  258
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T9 peptide

<400>  258

Ser Lys Thr Phe Asn Thr His Pro Gln Ser Thr Pro 
1               5                   10          


<210>  259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSP peptide

<400>  259

Ala Ser Ser Leu Asn Ile Ala 
1               5           


<210>  260
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  260
ggccaaacct cggcttacct gaaat                                             25


<210>  261
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  261
cagaattctg ccaattgctg ag                                                22


<210>  262
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  262
ttcttcagct tgtgtcatcc                                                   20


<210>  263
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  263
cccagtctac caccctatca gagc                                              24


<210>  264
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  264
cctgccttta aggcttcctt                                                   20


<210>  265
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified with a primary amine moiety

<400>  265
gtaactgtat ttggtacttc c                                                 21


<210>  266
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified with a PEG12CPP12 moiety

<400>  266
gtaactgtat ttggtacttc c                                                 21


<210>  267
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified with a CPP12-PEG12-K(CPP12)-PEG12-TFP moiety

<400>  267
ctgtatttgg tactt                                                        15


<210>  268
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified with a CPP12-PEG12-K(CPP12)-PEG12-TFP moiety

<400>  268
gtaactgtat ttggtacttc c                                                 21


<210>  269
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  6 membered morpholine rings replace deoxyribose rings

<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  linked by non-ionic phosphorodiamidate intersubunit linkages

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  modified with a Ac-NLS-Lys(CPP12)-PEG12-K(N3) moiety

<400>  269
gtaactgtat ttggtacttc c                                                 21


<210>  270
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  270
ctgtatttgg tactt                                                        15


<210>  271
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  271
ctcagacatg ccgctgct                                                     18


<210>  272
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  272
ttgagctgga tggttctctc cg                                                22


