                         SEQUENCE LISTING

<110>  Orionis Biosciences, Inc.
       Orionis Biosciences BV
 
<120>  DETECTION OF NOVEL DEGRADATION-RELATED INTERACTIONS

<130>  ORN-064PC/114384-5064

<150>  US 62/949,026
<151>  2019-12-17

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  1162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  1

Met Met Cys Gln Lys Phe Tyr Val Val Leu Leu His Trp Glu Phe Leu 
1               5                   10                  15      


Tyr Val Ile Ala Ala Leu Asn Leu Ala Tyr Pro Ile Ser Pro Trp Lys 
            20                  25                  30          


Phe Lys Leu Phe Cys Gly Pro Pro Asn Thr Thr Asp Asp Ser Phe Leu 
        35                  40                  45              


Ser Pro Ala Gly Ala Pro Asn Asn Ala Ser Ala Leu Lys Gly Ala Ser 
    50                  55                  60                  


Glu Ala Ile Val Glu Ala Lys Phe Asn Ser Ser Gly Ile Tyr Val Pro 
65                  70                  75                  80  


Glu Leu Ser Lys Thr Val Phe His Cys Cys Phe Gly Asn Glu Gln Gly 
                85                  90                  95      


Gln Asn Cys Ser Ala Leu Thr Asp Asn Thr Glu Gly Lys Thr Leu Ala 
            100                 105                 110         


Ser Val Val Lys Ala Ser Val Phe Arg Gln Leu Gly Val Asn Trp Asp 
        115                 120                 125             


Ile Glu Cys Trp Met Lys Gly Asp Leu Thr Leu Phe Ile Cys His Met 
    130                 135                 140                 


Glu Pro Leu Pro Lys Asn Pro Phe Lys Asn Tyr Asp Ser Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Asp Leu Pro Glu Val Ile Asp Asp Ser Pro Leu Pro Pro 
                165                 170                 175     


Leu Lys Asp Ser Phe Gln Thr Val Gln Cys Asn Cys Ser Leu Arg Gly 
            180                 185                 190         


Cys Glu Cys His Val Pro Val Pro Arg Ala Lys Leu Asn Tyr Ala Leu 
        195                 200                 205             


Leu Met Tyr Leu Glu Ile Thr Ser Ala Gly Val Ser Phe Gln Ser Pro 
    210                 215                 220                 


Leu Met Ser Leu Gln Pro Met Leu Val Val Lys Pro Asp Pro Pro Leu 
225                 230                 235                 240 


Gly Leu His Met Glu Val Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp 
                245                 250                 255     


Asp Ser Gln Thr Met Ala Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr 
            260                 265                 270         


Leu Glu Asn Ser Thr Ile Val Arg Glu Ala Ala Glu Ile Val Ser Ala 
        275                 280                 285             


Thr Ser Leu Leu Val Asp Ser Val Leu Pro Gly Ser Ser Tyr Glu Val 
    290                 295                 300                 


Gln Val Arg Ser Lys Arg Leu Asp Gly Ser Gly Val Trp Ser Asp Trp 
305                 310                 315                 320 


Ser Ser Pro Gln Val Phe Thr Thr Gln Asp Val Val Tyr Phe Pro Pro 
                325                 330                 335     


Lys Ile Leu Thr Ser Val Gly Ser Asn Ala Ser Phe His Cys Ile Tyr 
            340                 345                 350         


Lys Asn Glu Asn Gln Ile Ile Ser Ser Lys Gln Ile Val Trp Trp Arg 
        355                 360                 365             


Asn Leu Ala Glu Lys Ile Pro Glu Ile Gln Tyr Ser Ile Val Ser Asp 
    370                 375                 380                 


Arg Val Ser Lys Val Thr Phe Ser Asn Leu Lys Ala Thr Arg Pro Arg 
385                 390                 395                 400 


Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu Gln Ala Cys 
                405                 410                 415     


His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile 
            420                 425                 430         


Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser 
        435                 440                 445             


Pro Ser Thr Ile Gln Ser Leu Val Gly Ser Thr Val Gln Leu Arg Tyr 
    450                 455                 460                 


His Arg Arg Ser Leu Tyr Cys Pro Asp Ser Pro Ser Ile His Pro Thr 
465                 470                 475                 480 


Ser Glu Pro Lys Asn Cys Val Leu Gln Arg Asp Gly Phe Tyr Glu Cys 
                485                 490                 495     


Val Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg 
            500                 505                 510         


Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu 
        515                 520                 525             


Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Asn Val Lys Ala Glu 
    530                 535                 540                 


Ile Thr Val Asn Thr Gly Leu Leu Lys Val Ser Trp Glu Lys Pro Val 
545                 550                 555                 560 


Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly 
                565                 570                 575     


Lys Glu Ile Gln Trp Lys Thr His Glu Val Phe Asp Ala Lys Ser Lys 
            580                 585                 590         


Ser Ala Ser Leu Leu Val Ser Asp Leu Cys Ala Val Tyr Val Val Gln 
        595                 600                 605             


Val Arg Cys Arg Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser 
    610                 615                 620                 


Ser Pro Ala Tyr Thr Leu Val Met Asp Val Lys Val Pro Met Arg Gly 
625                 630                 635                 640 


Pro Glu Phe Trp Arg Lys Met Asp Gly Asp Val Thr Lys Lys Glu Arg 
                645                 650                 655     


Asn Val Thr Leu Leu Trp Lys Pro Leu Thr Lys Asn Asp Ser Leu Cys 
            660                 665                 670         


Ser Val Arg Arg Tyr Val Val Lys His Arg Thr Ala His Asn Gly Thr 
        675                 680                 685             


Trp Ser Glu Asp Val Gly Asn Arg Thr Asn Leu Thr Phe Leu Trp Thr 
    690                 695                 700                 


Glu Pro Ala His Thr Val Thr Val Leu Ala Val Asn Ser Leu Gly Ala 
705                 710                 715                 720 


Ser Leu Val Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val 
                725                 730                 735     


Ser Ala Val Glu Ser Leu Ser Ala Tyr Pro Leu Ser Ser Ser Cys Val 
            740                 745                 750         


Ile Leu Ser Trp Thr Leu Ser Pro Asp Asp Tyr Ser Leu Leu Tyr Leu 
        755                 760                 765             


Val Ile Glu Trp Lys Ile Leu Asn Glu Asp Asp Gly Met Lys Trp Leu 
    770                 775                 780                 


Arg Ile Pro Ser Asn Val Lys Lys Phe Tyr Ile His Asp Asn Phe Ile 
785                 790                 795                 800 


Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Val Phe Met Glu Gly 
                805                 810                 815     


Val Gly Lys Pro Lys Ile Ile Asn Gly Phe Thr Lys Asp Ala Ile Asp 
            820                 825                 830         


Lys Gln Gln Asn Asp Ala Gly Leu Tyr Val Ile Val Pro Ile Ile Ile 
        835                 840                 845             


Ser Ser Cys Val Leu Leu Leu Gly Thr Leu Leu Ile Ser His Gln Arg 
    850                 855                 860                 


Met Lys Lys Leu Phe Trp Asp Asp Val Pro Asn Pro Lys Asn Cys Ser 
865                 870                 875                 880 


Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr Phe Glu His Leu 
                885                 890                 895     


Phe Thr Lys His Ala Glu Ser Val Ile Phe Gly Pro Leu Leu Leu Glu 
            900                 905                 910         


Pro Glu Pro Ile Ser Glu Glu Ile Ser Val Asp Thr Ala Trp Lys Asn 
        915                 920                 925             


Lys Asp Glu Met Val Pro Ala Ala Met Val Ser Leu Leu Leu Thr Thr 
    930                 935                 940                 


Pro Asp Pro Glu Ser Ser Ser Ile Cys Ile Ser Asp Gln Cys Asn Ser 
945                 950                 955                 960 


Ala Asn Phe Ser Gly Ser Gln Ser Thr Gln Val Thr Cys Glu Asp Glu 
                965                 970                 975     


Cys Gln Arg Gln Pro Ser Val Lys Tyr Ala Thr Leu Val Ser Asn Asp 
            980                 985                 990         


Lys Leu Val Glu Thr Asp Glu Glu  Gln Gly Phe Ile His  Ser Pro Val 
        995                 1000                 1005             


Ser Asn  Cys Ile Ser Ser Asn  His Ser Pro Leu Arg  Gln Ser Phe 
    1010                 1015                 1020             


Ser Ser  Ser Ser Trp Glu Thr  Glu Ala Gln Thr Phe  Phe Leu Leu 
    1025                 1030                 1035             


Ser Asp  Gln Gln Pro Thr Met  Ile Ser Pro Gln Leu  Ser Phe Ser 
    1040                 1045                 1050             


Gly Leu  Asp Glu Leu Leu Glu  Leu Glu Gly Ser Phe  Pro Glu Glu 
    1055                 1060                 1065             


Asn His  Arg Glu Lys Ser Val  Cys Tyr Leu Gly Val  Thr Ser Val 
    1070                 1075                 1080             


Asn Arg  Arg Glu Ser Gly Val  Leu Leu Thr Gly Glu  Ala Gly Ile 
    1085                 1090                 1095             


Leu Cys  Thr Phe Pro Ala Gln  Cys Leu Phe Ser Asp  Ile Arg Ile 
    1100                 1105                 1110             


Leu Gln  Glu Arg Cys Ser His  Phe Val Glu Asn Asn  Leu Ser Leu 
    1115                 1120                 1125             


Gly Thr  Ser Gly Glu Asn Phe  Val Pro Tyr Met Pro  Gln Phe Gln 
    1130                 1135                 1140             


Thr Cys  Ser Thr His Ser His  Lys Ile Met Glu Asn  Lys Met Cys 
    1145                 1150                 1155             


Asp Leu  Thr Val 
    1160         


