                         SEQUENCE LISTING

<110>  EpiVax
 
<120>  MODIFIED INTERFERON-ALPHA-2 HAVING REDUCED IMMUNOGENICITY

<130>  EPV0027WO

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  1
gcacccgccc gctcgcccag ccccagcacg cagccctggg agtgtgatct gcctcaaacc       60

cacagcgcgg gtagcaggag gaccttgatg gccctggcac agatgaggag aatctctctt      120

ttctcctgct tgaaggacag acatgacttt ggatttcccc aggaggagtt tggcaaccag      180

gcccaaaagg ctgaaaccat ccctgtcctc catgagatga tccagcagat cttcgctgcc      240

ttcagcacaa aggactcatc tgctgcttgg gatgagaccc tcctagacaa attctacact      300

gaactctacc agcagctgaa tgacctggaa gcctgtgtga tacagggggt gggggtgaca      360

gagactcccc tgatgaagga ggactccatt gcggctgtga ggaaatacgc ccaaagaatc      420

actgcctatc tgaaagagaa gaaatacagc ccttgtgcct gggaggttgt cagagcagaa      480

accatgagat ctttttcttt gtcaacaaac gcgcaagaaa gtttaagaag taaggaatga      540


<210>  2
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Ala Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Ala Ala 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  3
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  3
gcacccgccc gctcgcccag ccccagcacg cagccctggg agtgtgatct gcctcaaacc       60

cacagcgcgg gtagcaggag gaccttgatg ctcctggcac agatgaggag aatctctctt      120

ttctcctgct tgaaggacag acatgacttt ggatttcccc aggaggagtt tggcaaccag      180

gcccaaaagg ctgaaaccat ccctgtcctc catgagatga tccagcagat cttcaatctc      240

ttcagcacaa aggactcatc tgctgcttgg gatgagaccc tcctagacaa attctacact      300

gaactctacc agcagctgaa tgacctggaa gcctgtgtga tacagggggt gggggtgaca      360

gagactcccc tgatgaagga ggactccatt gcggctgtga ggaaatacgc ccaaagaatc      420

actgcctatc tgaaagagaa gaaatacagc ccttgtgcct gggaggttgt cagagcagaa      480

atcatgagat ctttttcttt gtcaacaaac ttgcaagaaa gtttaagaag taaggaatga      540


<210>  4
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  5
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  5
gcacccgccc gctcgcccag ccccagcacg cagccctggg agtgtgatct gcctcaaacc       60

cacagcgcgg gtagcaggag gaccttgatg ctcctggcac agatgaggag aatctctctt      120

ttctcctgct tgaaggacag acatgacttt ggatttcccc aggaggagtt tggcaaccag      180

gcgcaaaagg ctgaaaccat ccctgtcctc catgagatga tccagcagat cttcaatctc      240

ttcagcacaa aggactcatc tgctgcttgg gatgagaccc tcctagacaa attctacact      300

gaactctacc agcagctgaa tgacctggaa gcctgtgtga tacagggggt gggggtgaca      360

gagactcccc tgatgaagga ggactccatt gcggctgtga ggaaatacgc ccaaagaatc      420

actgcctatc tgaaagagaa gaaatacagc ccttgtgcct gggaggttgt cagagcagaa      480

accatgagat ctttttcttt gtcaacaaac gcgcaagaaa gtttaagaag taaggaatga      540


<210>  6
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  7
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  7
gcacccgccc gctcgcccag ccccagcacg cagccctggg agtgtgatct gcctcaaacc       60

cacagcgcgg gtagcaggag gaccttgatg ctcctggcac agatgaggag aatctctctt      120

ttctcctgct tgaaggacag acatgacttt ggatttcccc aggaggagtt tggcaaccag      180

gcgcaaaagg ctgaaaccat ccctgtcctc catgagatga tccagcagat cttcgctgcc      240

ttcagcacaa aggactcatc tgctgcttgg gatgagaccc tcctagacaa attctacact      300

gaactctacc agcagctgaa tgacctggaa gcctgtgtga tacagggggt gggggtgaca      360

gagactcccc tgatgaagga ggactccatt gcggctgtga ggaaatacgc ccaaagaatc      420

actgcctatc tgaaagagaa gaaatacagc ccttgtgcct gggaggttgt cagagcagaa      480

atcatgagat ctttttcttt gtcaacaaac ttgcaagaaa gtttaagaag taaggaatga      540


<210>  8
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Ala Ala 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  9
<211>  543
<212>  DNA
<213>  Homo sapiens

<400>  9
gcacccgccc gctcgcccag ccccagcacg cagccctggg agtgtgacct accacaaacc       60

cacagcctgg gtagcaggag gaccttgatg ctcctggcgc agatgaggag aatctctctt      120

ttctcctgct tgaaggacag acatgacttt ggatttcccc aggaggagtt tggcaaccag      180

ttccaaaagg ctgaaaccat ccctgtcctc catgagatga tccagcagat cttcaacctc      240

ttcagcacaa aagactcatc tgctgcttgg gatgagaccc tcctagacaa attctacact      300

gaactctacc agcagctgaa tgacctggaa gcctgtgtga tacagggggt gggggtgaca      360

gagactcccc tgatgaagga ggactccatt ctggctgtga ggaaatactt ccaaagaatc      420

actctctatc tgaaagagaa gaaatacagc ccttgtgcct gggaggttgt cagagcagaa      480

atcatgagat ctttttcttt gtcaacaaac ttgcaagaaa gtttaagatc taaagagtaa      540

tga                                                                    543


<210>  10
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  11
<211>  501
<212>  DNA
<213>  Homo sapiens

<400>  11
tgtgacctac cacaaaccca cagcctgggt agcaggagga ccttgatgct cctggcgcag       60

atgaggagaa tctctctttt ctcctgcttg aaggacagac atgactttgg atttccccag      120

gaggagtttg gcaaccagtt ccaaaaggct gaaaccatcc ctgtcctcca tgagatgatc      180

cagcagatct tcaacctctt cagcacaaaa gactcatctg ctgcttggga tgagaccctc      240

ctagacaaat tctacactga actctaccag cagctgaatg acctggaagc ctgtgtgata      300

cagggggtgg gggtgacaga gactcccctg atgaaggagg actccattct ggctgtgagg      360

aaatacttcc aaagaatcac tctctatctg aaagagaaga aatacagccc ttgtgcctgg      420

gaggttgtca gagcagaaat catgagatct ttttctttgt caacaaactt gcaagaaagt      480

ttaagatcta aagagtaatg a                                                501


<210>  12
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  13
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  13
tgtgatctgc ctcaaaccca cagcgcgggt agcaggagga ccttgatggc cctggcacag       60

atgaggagaa tctctctttt ctcctgcttg aaggacagac atgactttgg atttccccag      120

gaggagtttg gcaaccaggc ccaaaaggct gaaaccatcc ctgtcctcca tgagatgatc      180

cagcagatct tcgctgcctt cagcacaaag gactcatctg ctgcttggga tgagaccctc      240

ctagacaaat tctacactga actctaccag cagctgaatg acctggaagc ctgtgtgata      300

cagggggtgg gggtgacaga gactcccctg atgaaggagg actccattgc ggctgtgagg      360

aaatacgccc aaagaatcac tgcctatctg aaagagaaga aatacagccc ttgtgcctgg      420

gaggttgtca gagcagaaac catgagatct ttttctttgt caacaaacgc gcaagaaagt      480

ttaagaagta aggaatga                                                    498


<210>  14
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Ala Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Ala Ala Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  15
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  15
tgtgatctgc ctcaaaccca cagcgcgggt agcaggagga ccttgatgct cctggcacag       60

atgaggagaa tctctctttt ctcctgcttg aaggacagac atgactttgg atttccccag      120

gaggagtttg gcaaccaggc ccaaaaggct gaaaccatcc ctgtcctcca tgagatgatc      180

cagcagatct tcaatctctt cagcacaaag gactcatctg ctgcttggga tgagaccctc      240

ctagacaaat tctacactga actctaccag cagctgaatg acctggaagc ctgtgtgata      300

cagggggtgg gggtgacaga gactcccctg atgaaggagg actccattgc ggctgtgagg      360

aaatacgccc aaagaatcac tgcctatctg aaagagaaga aatacagccc ttgtgcctgg      420

gaggttgtca gagcagaaat catgagatct ttttctttgt caacaaactt gcaagaaagt      480

ttaagaagta aggaatga                                                    498


<210>  16
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  17
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  17
tgtgatctgc ctcaaaccca cagcgcgggt agcaggagga ccttgatgct cctggcacag       60

atgaggagaa tctctctttt ctcctgcttg aaggacagac atgactttgg atttccccag      120

gaggagtttg gcaaccaggc gcaaaaggct gaaaccatcc ctgtcctcca tgagatgatc      180

cagcagatct tcaatctctt cagcacaaag gactcatctg ctgcttggga tgagaccctc      240

ctagacaaat tctacactga actctaccag cagctgaatg acctggaagc ctgtgtgata      300

cagggggtgg gggtgacaga gactcccctg atgaaggagg actccattgc ggctgtgagg      360

aaatacgccc aaagaatcac tgcctatctg aaagagaaga aatacagccc ttgtgcctgg      420

gaggttgtca gagcagaaac catgagatct ttttctttgt caacaaacgc gcaagaaagt      480

ttaagaagta aggaatga                                                    498


<210>  18
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  19
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  19
tgtgatctgc ctcaaaccca cagcgcgggt agcaggagga ccttgatgct cctggcacag       60

atgaggagaa tctctctttt ctcctgcttg aaggacagac atgactttgg atttccccag      120

gaggagtttg gcaaccaggc gcaaaaggct gaaaccatcc ctgtcctcca tgagatgatc      180

cagcagatct tcgctgcctt cagcacaaag gactcatctg ctgcttggga tgagaccctc      240

ctagacaaat tctacactga actctaccag cagctgaatg acctggaagc ctgtgtgata      300

cagggggtgg gggtgacaga gactcccctg atgaaggagg actccattgc ggctgtgagg      360

aaatacgccc aaagaatcac tgcctatctg aaagagaaga aatacagccc ttgtgcctgg      420

gaggttgtca gagcagaaat catgagatct ttttctttgt caacaaactt gcaagaaagt      480

ttaagaagta aggaatga                                                    498


<210>  20
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Ala Ala Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  21
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  22
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  22

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  23
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg Arg 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  24
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  25
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  25
gcacccgccc gctcgcccag ccccagcacg cagccctggg ag                          42


<210>  26
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu 
1               5                   10                  


<210>  27
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Ala Leu 
            20                  25                  30          


Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Ala Ala 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  28
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  29
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  30
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Ala Ala 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  31
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  31

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Ala Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Ala Ala Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  32
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  33
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  33

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  34
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  34

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Ala Ala Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  35
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Ala Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg Arg 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Ala Ala 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  36
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg Arg 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  37
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg Arg 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  38
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg Arg 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Ala Ala 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu 
            


<210>  39
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  39

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Ala Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Ala Ala Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  40
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  41
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  41

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Thr Met Arg Ser Phe Ser Leu Ser Thr Asn Ala Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


<210>  42
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  42

Cys Asp Leu Pro Gln Thr His Ser Ala Gly Ser Arg Arg Thr Leu Met 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp 
            20                  25                  30          


Arg Arg Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Ala Gln 
        35                  40                  45              


Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe 
    50                  55                  60                  


Ala Ala Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu 
                85                  90                  95      


Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys 
            100                 105                 110         


Glu Asp Ser Ile Ala Ala Val Arg Lys Tyr Ala Gln Arg Ile Thr Ala 
        115                 120                 125             


Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg 
    130                 135                 140                 


Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser 
145                 150                 155                 160 


Leu Arg Ser Lys Glu 
                165 


