                         SEQUENCE LISTING

<110>  NOVAROCK BIOTHERAPEUTICS, LTD.
 
<120>  ANTI-INTERLEUKIN-23 P19 ANTIBODIES AND METHODS OF USE THEREOF

<130>  122863-5002

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-2_VH

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Arg Ala Phe Tyr Tyr Tyr Gly Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-2_VL

<400>  2

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Asn Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Ala 
                85                  90                  95      


Thr Gln Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-4_VH

<400>  3

Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Ser Gly Asn Thr Asp Tyr Ser Gln His Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Ala Asn Trp Tyr Asp Tyr Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu--4_VL

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Gly Gly Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Thr Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile His Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Ile Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-5_VH

<400>  5

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Phe Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg His Gly Val Arg Gly Val Ile Pro His Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-5_VL

<400>  6

Gln Thr Val Leu Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Asn Ser Gly Ser Val Ser Thr Ile 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Ala 
        35                  40                  45              


Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Phe Leu Gly Ser 
                85                  90                  95      


Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-6_VH

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Tyr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Gly Gln Lys Val 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Glu Asn Ile Asn Trp Arg Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-6_VL

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-2_VH-CDR1

<400>  9

Gly Tyr Thr Phe Thr Thr Tyr Gly 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-2_VH-CDR2

<400>  10

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-2_VH-CDR3

<400>  11

Ala Arg Glu Trp Arg Ala Phe Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-2_VL-CDR1

<400>  12

Gln Ser Leu Glu His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  13
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-2_VL-CDR2

<400>  13

Lys Val Ser 
1           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-2_VL-CDR3

<400>  14

Thr Gln Ala Thr Gln Phe Pro Leu Thr 
1               5                   


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-4_VH-CDR1

<400>  15

Gly Tyr Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-4_VH-CDR2

<400>  16

Ile Ser Ala Tyr Ser Gly Asn Thr 
1               5               


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-4_VH-CDR3

<400>  17

Ala Arg Ala Ser Ala Asn Trp Tyr Asp Tyr Phe Asp Pro 
1               5                   10              


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu--4_VL-CDR1

<400>  18

Gln Thr Ile Gly Gly Ser 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu--4_VL-CDR2

<400>  19

Tyr Ala Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu--4_VL-CDR3

<400>  20

His Gln Ser Ser Ile Leu Pro Tyr Thr 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-5_VH-CDR1

<400>  21

Gly Gly Ser Ile Ser Ser Ser Ser Phe Tyr 
1               5                   10  


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-5_VH-CDR2

<400>  22

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-5_VH-CDR3

<400>  23

Ala Arg His Gly Val Arg Gly Val Ile Pro His Phe Asp Tyr 
1               5                   10                  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-5_VL-CDR1

<400>  24

Ser Gly Ser Val Ser Thr Ile Tyr Tyr 
1               5                   


<210>  25
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-5_VL-CDR2

<400>  25

Ser Thr Asn 
1           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-5_VL-CDR3

<400>  26

Val Leu Phe Leu Gly Ser Gly Leu Val 
1               5                   


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-6_VH-CDR1

<400>  27

Gly Tyr Thr Phe Thr Tyr Tyr Gly 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-6_VH-CDR2

<400>  28

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-6_VH-CDR3

<400>  29

Val Thr Glu Asn Ile Asn Trp Arg Asp Ala Phe Asp Ile 
1               5                   10              


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-6_VL-CDR1

<400>  30

Gln Thr Ile Gly Ser Ser 
1               5       


<210>  31
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-6_VL-CDR2

<400>  31

Tyr Ala Ser 
1           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu-6_VL-CDR3

<400>  32

His Gln Ser Ser Ser Leu Pro Tyr Thr 
1               5                   


