                         SEQUENCE LISTING

<110>  Dr. Kalali, Prof. Mostafazadeh, Dipl. Ing. Miedl (KMM), 
       Gesellschaft brgerlichen Rechts
 
<120>  A composition and its use for a universal therapy against tumor 
       cells

<130>  P49450-WO

<150>  EP19218585.8
<151>  2019-12-20

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  2
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val  Gly Phe Asp Glu Phe  Gly Ser Val 
        995                 1000                 1005             


Asp Phe  Ser Gly Thr Phe Tyr  Val Asn Thr Asp Arg  Asp Asp Asp 
    1010                 1015                 1020             


Tyr Ala  Gly Phe Val Phe Gly  Tyr Gln Ser Ser Ser  Arg Phe Tyr 
    1025                 1030                 1035             


Val Val  Met Trp Lys Gln Val  Thr Gln Thr Tyr Trp  Glu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Arg Ala Tyr Gly Tyr  Ser Gly Val Ser Leu  Lys Val Val 
    1055                 1060                 1065             


Asn Ser  Thr Thr Gly Thr Gly  Glu His Leu Arg Asn  Ala Leu Trp 
    1070                 1075                 1080             


His Thr  Gly Asn Thr Pro Gly  Gln Val Arg Thr Leu  Trp His Asp 
    1085                 1090                 1095             


Pro Arg  Asn Ile Gly Trp Lys  Asp Tyr Thr Ala Tyr  Arg Trp His 
    1100                 1105                 1110             


Leu Thr  His Arg Pro Lys Thr  Gly Tyr Ile Arg Val  Leu Val His 
    1115                 1120                 1125             


Glu Gly  Lys Gln Val Met Ala  Asp Ser Gly Pro Ile  Tyr Asp Gln 
    1130                 1135                 1140             


Thr Tyr  Ala Gly Gly Arg Leu  Gly Leu Phe Val Phe  Ser Gln Glu 
    1145                 1150                 1155             


Met Val  Tyr Phe Ser Asp Leu  Lys Tyr Glu Cys Arg  Asp Ile 
    1160                 1165                 1170         


<210>  3
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val 
            20                  25                  30          


His Pro Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys 
        35                  40                  45              


Ala Val Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys 
65                  70                  75                  80  


Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala 
                85                  90                  95      


Val Cys Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile 
            100                 105                 110         


Ala Gly Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp 
        115                 120                 125             


Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu 
    130                 135                 140                 


Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro 
145                 150                 155                 160 


Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp 
                165                 170                 175     


Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala 
            180                 185                 190         


Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala 
        195                 200                 205             


Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215                 220 


<210>  4
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Pro Leu Cys Leu Val Ala Ala Leu Leu Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Pro Ser Leu Gly Asp Glu Ala Ile His Cys Pro Pro Cys Ser Glu 
            20                  25                  30          


Glu Lys Leu Ala Arg Cys Arg Pro Pro Val Gly Cys Glu Glu Leu Val 
        35                  40                  45              


Arg Glu Pro Gly Cys Gly Cys Cys Ala Thr Cys Ala Leu Gly Leu Gly 
    50                  55                  60                  


Met Pro Cys Gly Val Tyr Thr Pro Arg Cys Gly Ser Gly Leu Arg Cys 
65                  70                  75                  80  


Tyr Pro Pro Arg Gly Val Glu Lys Pro Leu His Thr Leu Met His Gly 
                85                  90                  95      


Gln Gly Val Cys Met Glu Leu Ala Glu Ile Glu Ala Ile Gln Glu Ser 
            100                 105                 110         


Leu Gln Pro Ser Asp Lys Asp Glu Gly Asp His Pro Asn Asn Ser Phe 
        115                 120                 125             


Ser Pro Cys Ser Ala His Asp Arg Arg Cys Leu Gln Lys His Phe Ala 
    130                 135                 140                 


Lys Ile Arg Asp Arg Ser Thr Ser Gly Gly Lys Met Lys Val Asn Gly 
145                 150                 155                 160 


Ala Pro Arg Glu Asp Ala Arg Pro Val Pro Gln Gly Ser Cys Gln Ser 
                165                 170                 175     


Glu Leu His Arg Ala Leu Glu Arg Leu Ala Ala Ser Gln Ser Arg Thr 
            180                 185                 190         


His Glu Asp Leu Tyr Ile Ile Pro Ile Pro Asn Cys Asp Arg Asn Gly 
        195                 200                 205             


Asn Phe His Pro Lys Gln Cys His Pro Ala Leu Asp Gly Gln Arg Gly 
    210                 215                 220                 


Lys Cys Trp Cys Val Asp Arg Lys Thr Gly Val Lys Leu Pro Gly Gly 
225                 230                 235                 240 


Leu Glu Pro Lys Gly Glu Leu Asp Cys His Gln Leu Ala Asp Ser Phe 
                245                 250                 255     


Arg Glu 
        


<210>  5
<211>  1401
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Met Asn Cys Trp Phe Ser Cys Thr Pro Lys Asn Arg His Ala Ala 
1               5                   10                  15      


Asp Trp Asn Lys Tyr Asp Asp Arg Leu Met Lys Ala Ala Glu Arg Gly 
            20                  25                  30          


Asp Val Glu Lys Val Thr Ser Ile Leu Ala Lys Lys Gly Val Asn Pro 
        35                  40                  45              


Gly Lys Leu Asp Val Glu Gly Arg Ser Val Phe His Val Val Thr Ser 
    50                  55                  60                  


Lys Gly Asn Leu Glu Cys Leu Asn Ala Ile Leu Ile His Gly Val Asp 
65                  70                  75                  80  


Ile Thr Thr Ser Asp Thr Ala Gly Arg Asn Ala Leu His Leu Ala Ala 
                85                  90                  95      


Lys Tyr Gly His Ala Leu Cys Leu Gln Lys Leu Leu Gln Tyr Asn Cys 
            100                 105                 110         


Pro Thr Glu His Ala Asp Leu Gln Gly Arg Thr Ala Leu His Asp Ala 
        115                 120                 125             


Ala Met Ala Asp Cys Pro Ser Ser Ile Gln Leu Leu Cys Asp His Gly 
    130                 135                 140                 


Ala Ser Val Asn Ala Lys Asp Val Asp Gly Arg Thr Pro Leu Val Leu 
145                 150                 155                 160 


Ala Thr Gln Met Ser Arg Pro Thr Ile Cys Gln Leu Leu Ile Asp Arg 
                165                 170                 175     


Gly Ala Asp Val Asn Ser Arg Asp Lys Gln Asn Arg Thr Ala Leu Met 
            180                 185                 190         


Leu Gly Cys Glu Tyr Gly Cys Arg Asp Ala Val Glu Val Leu Ile Lys 
        195                 200                 205             


Asn Gly Ala Asp Ile Ser Leu Leu Asp Ala Leu Gly His Asp Ser Ser 
    210                 215                 220                 


Tyr Tyr Ala Arg Ile Gly Asp Asn Leu Asp Ile Leu Thr Leu Leu Lys 
225                 230                 235                 240 


Thr Ala Ser Glu Asn Thr Asn Lys Gly Arg Glu Leu Trp Lys Lys Gly 
                245                 250                 255     


Pro Ser Leu Gln Gln Arg Asn Leu Thr His Met Gln Asp Glu Val Asn 
            260                 265                 270         


Val Lys Ser His Gln Arg Glu His Gln Asn Ile Gln Asp Leu Glu Ile 
        275                 280                 285             


Glu Asn Glu Asp Leu Lys Glu Arg Leu Arg Lys Ile Gln Gln Glu Gln 
    290                 295                 300                 


Arg Ile Leu Leu Asp Lys Val Asn Gly Leu Gln Leu Gln Leu Asn Glu 
305                 310                 315                 320 


Glu Val Met Val Ala Asp Asp Leu Glu Ser Glu Arg Glu Lys Leu Lys 
                325                 330                 335     


Ser Leu Leu Ala Ala Lys Glu Lys Gln His Glu Glu Ser Leu Arg Thr 
            340                 345                 350         


Ile Glu Ala Leu Lys Asn Arg Phe Lys Tyr Phe Glu Ser Asp His Leu 
        355                 360                 365             


Gly Ser Gly Ser His Phe Arg Lys Glu Asp Met Leu Leu Lys Gln Gly 
    370                 375                 380                 


Gln Met Tyr Met Ala Asp Ser Gln Cys Thr Ser Pro Gly Ile Pro Ala 
385                 390                 395                 400 


His Met Gln Ser Arg Ser Met Leu Arg Pro Leu Glu Leu Ser Leu Pro 
                405                 410                 415     


Ser Gln Thr Ser Tyr Ser Glu Asn Glu Ile Leu Lys Lys Glu Leu Glu 
            420                 425                 430         


Ala Met Arg Thr Phe Cys Glu Ser Ala Lys Gln Asp Arg Leu Lys Leu 
        435                 440                 445             


Gln Asn Glu Leu Ala His Lys Val Ala Glu Cys Lys Ala Leu Ala Leu 
    450                 455                 460                 


Glu Cys Glu Arg Val Lys Glu Asp Ser Asp Glu Gln Ile Lys Gln Leu 
465                 470                 475                 480 


Glu Asp Ala Leu Lys Asp Val Gln Lys Arg Met Tyr Glu Ser Glu Gly 
                485                 490                 495     


Lys Val Lys Gln Met Gln Thr His Phe Leu Ala Leu Lys Glu His Leu 
            500                 505                 510         


Thr Ser Glu Ala Ala Ser Gly Asn His Arg Leu Thr Glu Glu Leu Lys 
        515                 520                 525             


Asp Gln Leu Lys Asp Leu Lys Val Lys Tyr Glu Gly Ala Ser Ala Glu 
    530                 535                 540                 


Val Gly Lys Leu Arg Asn Gln Ile Lys Gln Asn Glu Met Ile Val Glu 
545                 550                 555                 560 


Glu Phe Lys Arg Asp Glu Gly Lys Leu Ile Glu Glu Asn Lys Arg Leu 
                565                 570                 575     


Gln Lys Glu Leu Ser Met Cys Glu Met Glu Arg Glu Lys Lys Gly Arg 
            580                 585                 590         


Lys Val Thr Glu Met Glu Gly Gln Ala Lys Glu Leu Ser Ala Lys Leu 
        595                 600                 605             


Ala Leu Ser Ile Pro Ala Glu Lys Phe Glu Asn Met Lys Ser Ser Leu 
    610                 615                 620                 


Ser Asn Glu Val Asn Glu Lys Ala Lys Lys Leu Val Glu Met Glu Arg 
625                 630                 635                 640 


Glu His Glu Lys Ser Leu Ser Glu Ile Arg Gln Leu Lys Arg Glu Leu 
                645                 650                 655     


Glu Asn Val Lys Ala Lys Leu Ala Gln His Val Lys Pro Glu Glu His 
            660                 665                 670         


Glu Gln Val Lys Ser Arg Leu Glu Gln Lys Ser Gly Glu Leu Gly Lys 
        675                 680                 685             


Lys Ile Thr Glu Leu Thr Leu Lys Asn Gln Thr Leu Gln Lys Glu Ile 
    690                 695                 700                 


Glu Lys Val Tyr Leu Asp Asn Lys Leu Leu Lys Glu Gln Ala His Asn 
705                 710                 715                 720 


Leu Thr Ile Glu Met Lys Asn His Tyr Val Pro Leu Lys Val Ser Glu 
                725                 730                 735     


Asp Met Lys Lys Ser His Asp Ala Ile Ile Asp Asp Leu Asn Arg Lys 
            740                 745                 750         


Leu Leu Asp Val Thr Gln Lys Tyr Thr Glu Lys Lys Leu Glu Met Glu 
        755                 760                 765             


Lys Leu Leu Leu Glu Asn Asp Ser Leu Ser Lys Asp Val Ser Arg Leu 
    770                 775                 780                 


Glu Thr Val Phe Val Pro Pro Glu Lys His Glu Lys Glu Ile Ile Ala 
785                 790                 795                 800 


Leu Lys Ser Asn Ile Val Glu Leu Lys Lys Gln Leu Ser Glu Leu Lys 
                805                 810                 815     


Lys Lys Cys Gly Glu Asp Gln Glu Lys Ile His Ala Leu Thr Ser Glu 
            820                 825                 830         


Asn Thr Asn Leu Lys Lys Met Met Ser Asn Gln Tyr Val Pro Val Lys 
        835                 840                 845             


Thr His Glu Glu Val Lys Met Thr Leu Asn Asp Thr Leu Ala Lys Thr 
    850                 855                 860                 


Asn Arg Glu Leu Leu Asp Val Lys Lys Lys Phe Glu Asp Ile Asn Gln 
865                 870                 875                 880 


Glu Phe Val Lys Ile Lys Asp Lys Asn Glu Ile Leu Lys Arg Asn Leu 
                885                 890                 895     


Glu Asn Thr Gln Asn Gln Ile Lys Ala Glu Tyr Ile Ser Leu Ala Glu 
            900                 905                 910         


His Glu Ala Lys Met Ser Ser Leu Ser Gln Ser Met Arg Lys Val Gln 
        915                 920                 925             


Asp Ser Asn Ala Glu Ile Leu Ala Asn Tyr Arg Lys Gly Gln Glu Glu 
    930                 935                 940                 


Ile Val Thr Leu His Ala Glu Ile Lys Ala Gln Lys Lys Glu Leu Asp 
945                 950                 955                 960 


Thr Ile Gln Glu Cys Ile Lys Val Lys Tyr Ala Pro Ile Val Ser Phe 
                965                 970                 975     


Glu Glu Cys Glu Arg Lys Phe Lys Ala Thr Glu Lys Glu Leu Lys Asp 
            980                 985                 990         


Gln Leu Ser Glu Gln Thr Gln Lys  Tyr Ser Val Ser Glu  Glu Glu Val 
        995                 1000                 1005             


Lys Lys  Asn Lys Gln Glu Asn  Asp Lys Leu Lys Lys  Glu Ile Phe 
    1010                 1015                 1020             


Thr Leu  Gln Lys Asp Leu Arg  Asp Lys Thr Val Leu  Ile Glu Lys 
    1025                 1030                 1035             


Ser His  Glu Met Glu Arg Ala  Leu Ser Arg Lys Thr  Asp Glu Leu 
    1040                 1045                 1050             


Asn Lys  Gln Leu Lys Asp Leu  Ser Gln Lys Tyr Thr  Glu Val Lys 
    1055                 1060                 1065             


Asn Val  Lys Glu Lys Leu Val  Glu Glu Asn Ala Lys  Gln Thr Ser 
    1070                 1075                 1080             


Glu Ile  Leu Ala Val Gln Asn  Leu Leu Gln Lys Gln  His Val Pro 
    1085                 1090                 1095             


Leu Glu  Gln Val Glu Ala Leu  Lys Lys Ser Leu Asn  Gly Thr Ile 
    1100                 1105                 1110             


Glu Asn  Leu Lys Glu Glu Leu  Lys Ser Met Gln Arg  Cys Tyr Glu 
    1115                 1120                 1125             


Lys Glu  Gln Gln Thr Val Thr  Lys Leu His Gln Leu  Leu Glu Asn 
    1130                 1135                 1140             


Gln Lys  Asn Ser Ser Val Pro  Leu Ala Glu His Leu  Gln Ile Lys 
    1145                 1150                 1155             


Glu Ala  Phe Glu Lys Glu Val  Gly Ile Ile Lys Ala  Ser Leu Arg 
    1160                 1165                 1170             


Glu Lys  Glu Glu Glu Ser Gln  Asn Lys Met Glu Glu  Val Ser Lys 
    1175                 1180                 1185             


Leu Gln  Ser Glu Val Gln Asn  Thr Lys Gln Ala Leu  Lys Lys Leu 
    1190                 1195                 1200             


Glu Thr  Arg Glu Val Val Asp  Leu Ser Lys Tyr Lys  Ala Thr Lys 
    1205                 1210                 1215             


Ser Asp  Leu Glu Thr Gln Ile  Ser Ser Leu Asn Glu  Lys Leu Ala 
    1220                 1225                 1230             


Asn Leu  Asn Arg Lys Tyr Glu  Glu Val Cys Glu Glu  Val Leu His 
    1235                 1240                 1245             


Ala Lys  Lys Lys Glu Ile Ser  Ala Lys Asp Glu Lys  Glu Leu Leu 
    1250                 1255                 1260             


His Phe  Ser Ile Glu Gln Glu  Ile Lys Asp Gln Lys  Glu Arg Cys 
    1265                 1270                 1275             


Asp Lys  Ser Leu Thr Thr Ile  Thr Glu Leu Gln Arg  Arg Ile Gln 
    1280                 1285                 1290             


Glu Ser  Ala Lys Gln Ile Glu  Ala Lys Asp Asn Lys  Ile Thr Glu 
    1295                 1300                 1305             


Leu Leu  Asn Asp Val Glu Arg  Leu Lys Gln Ala Leu  Asn Gly Leu 
    1310                 1315                 1320             


Ser Gln  Leu Thr Tyr Thr Ser  Gly Asn Pro Thr Lys  Arg Gln Ser 
    1325                 1330                 1335             


Gln Leu  Ile Asp Thr Leu Gln  His Gln Val Lys Ser  Leu Glu Gln 
    1340                 1345                 1350             


Gln Leu  Ala Asp Ala Asp Arg  Gln His Gln Glu Val  Ile Ala Ile 
    1355                 1360                 1365             


Tyr Arg  Thr His Leu Leu Ser  Ala Ala Gln Gly His  Met Asp Glu 
    1370                 1375                 1380             


Asp Val  Gln Glu Ala Leu Leu  Gln Ile Ile Gln Met  Arg Gln Gly 
    1385                 1390                 1395             


Leu Val  Cys 
    1400     


<210>  6
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser Leu Gly Ser Phe Val His Cys Glu Pro Cys Asp Glu 
            20                  25                  30          


Lys Ala Leu Ser Met Cys Pro Pro Ser Pro Leu Gly Cys Glu Leu Val 
        35                  40                  45              


Lys Glu Pro Gly Cys Gly Cys Cys Met Thr Cys Ala Leu Ala Glu Gly 
    50                  55                  60                  


Gln Ser Cys Gly Val Tyr Thr Glu Arg Cys Ala Gln Gly Leu Arg Cys 
65                  70                  75                  80  


Leu Pro Arg Gln Asp Glu Glu Lys Pro Leu His Ala Leu Leu His Gly 
                85                  90                  95      


Arg Gly Val Cys Leu Asn Glu Lys Ser Tyr Arg Glu Gln Val Lys Ile 
            100                 105                 110         


Glu Arg Asp Ser Arg Glu His Glu Glu Pro Thr Thr Ser Glu Met Ala 
        115                 120                 125             


Glu Glu Thr Tyr Ser Pro Lys Ile Phe Arg Pro Lys His Thr Arg Ile 
    130                 135                 140                 


Ser Glu Leu Lys Ala Glu Ala Val Lys Lys Asp Arg Arg Lys Lys Leu 
145                 150                 155                 160 


Thr Gln Ser Lys Phe Val Gly Gly Ala Glu Asn Thr Ala His Pro Arg 
                165                 170                 175     


Ile Ile Ser Ala Pro Glu Met Arg Gln Glu Ser Glu Gln Gly Pro Cys 
            180                 185                 190         


Arg Arg His Met Glu Ala Ser Leu Gln Glu Leu Lys Ala Ser Pro Arg 
        195                 200                 205             


Met Val Pro Arg Ala Val Tyr Leu Pro Asn Cys Asp Arg Lys Gly Phe 
    210                 215                 220                 


Tyr Lys Arg Lys Gln Cys Lys Pro Ser Arg Gly Arg Lys Arg Gly Ile 
225                 230                 235                 240 


Cys Trp Cys Val Asp Lys Tyr Gly Met Lys Leu Pro Gly Met Glu Tyr 
                245                 250                 255     


Val Asp Gly Asp Phe Gln Cys His Thr Phe Asp Ser Ser Asn Val Glu 
            260                 265                 270         


<210>  7
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile 
    50                  55                  60                  


Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp 
65                  70                  75                  80  


Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp 
        115                 120                 125             


Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn 
            180                 185                 190         


Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr 
225                 230                 235                 240 


His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile 
                245                 250                 255     


Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr 
            260                 265                 270         


Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala 
        275                 280                 285             


Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly 
    290                 295                 300                 


Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg 
305                 310                 315                 320 


Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu 
                325                 330                 335     


Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
            340                 345                 350         


Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
        355                 360                 365             


Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr 
    370                 375                 380                 


Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr 
385                 390                 395                 400 


Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn 
                405                 410                 415     


Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly 
            420                 425                 430         


Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr 
        435                 440                 445             


Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys 
    450                 455                 460                 


Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
465                 470                 475         


<210>  8
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  9
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
1               5                   10                  15      


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
            20                  25                  30          


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
        35                  40                  45              


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
    50                  55                  60                  


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
65                  70                  75                  80  


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
                85                  90                  95      


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
            100                 105                 110         


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
        115                 120                 125             


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
    130                 135                 140             


<210>  10
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  10

Met His Leu Leu Ala Ile Leu Phe Cys Ala Leu Trp Ser Ala Val Leu 
1               5                   10                  15      


Ala Glu Asn Ser Asp Asp Tyr Asp Leu Met Tyr Val Asn Leu Asp Asn 
            20                  25                  30          


Glu Ile Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Ala 
        35                  40                  45              


Cys Gly Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu 
    50                  55                  60                  


Asn Ser Gln Met Arg Glu Arg Met Leu Leu Gln Ala Thr Asp Asp Val 
65                  70                  75                  80  


Leu Arg Gly Glu Leu Gln Arg Leu Arg Glu Glu Leu Gly Arg Leu Ala 
                85                  90                  95      


Glu Ser Leu Ala Arg Pro Cys Ala Pro Gly Ala Pro Ala Glu Ala Arg 
            100                 105                 110         


Leu Thr Ser Ala Leu Asp Glu Leu Leu Gln Ala Thr Arg Asp Ala Gly 
        115                 120                 125             


Arg Arg Leu Ala Arg Met Glu Gly Ala Glu Ala Gln Arg Pro Glu Glu 
    130                 135                 140                 


Ala Gly Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln Thr Arg 
145                 150                 155                 160 


Ala Asp Leu His Ala Val Gln Gly Trp Ala Ala Arg Ser Trp Leu Pro 
                165                 170                 175     


Ala Gly Cys Glu Thr Ala Ile Leu Phe Pro Met Arg Ser Lys Lys Ile 
            180                 185                 190         


Phe Gly Ser Val His Pro Val Arg Pro Met Arg Leu Glu Ser Phe Ser 
        195                 200                 205             


Ala Cys Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu 
    210                 215                 220                 


Phe Ser Tyr Gly Thr Lys Arg Asn Pro Tyr Glu Ile Gln Leu Tyr Leu 
225                 230                 235                 240 


Ser Tyr Gln Ser Ile Val Phe Val Val Gly Gly Glu Glu Asn Lys Leu 
                245                 250                 255     


Val Ala Glu Ala Met Val Ser Leu Gly Arg Trp Thr His Leu Cys Gly 
            260                 265                 270         


Thr Trp Asn Ser Glu Glu Gly Leu Thr Ser Leu Trp Val Asn Gly Glu 
        275                 280                 285             


Leu Ala Ala Thr Thr Val Glu Met Ala Thr Gly His Ile Val Pro Glu 
    290                 295                 300                 


Gly Gly Ile Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly 
305                 310                 315                 320 


Gly Gly Phe Asp Glu Thr Leu Ala Phe Ser Gly Arg Leu Thr Gly Phe 
                325                 330                 335     


Asn Ile Trp Asp Ser Val Leu Ser Asn Glu Glu Ile Arg Glu Thr Gly 
            340                 345                 350         


Gly Ala Glu Ser Cys His Ile Arg Gly Asn Ile Val Gly Trp Gly Val 
        355                 360                 365             


Thr Glu Ile Gln Pro His Gly Gly Ala Gln Tyr Val Ser 
    370                 375                 380     


<210>  11
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210>  12
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
            20                  25                  30          


Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
        35                  40                  45              


Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
    50                  55                  60                  


Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
65                  70                  75                  80  


Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                85                  90                  95      


His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
            100                 105                 110         


Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
        115                 120                 125             


Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
    130                 135                 140                 


Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
145                 150                 155                 160 


Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                165                 170                 175     


Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
            180                 185                 190         


Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
        195                 200                 205             


Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
    210                 215                 220                 


Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
225                 230                 235                 240 


Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                245                 250                 255     


Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
            260                 265                 270         


Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
        275                 280                 285             


Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
    290                 295                 300                 


Thr Lys Glu Ile 
305             


<210>  13
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Gln Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Leu Gln Gln Glu Lys Thr Asp Thr Val Arg 
                565                 570                 575     


Cys Ile Lys Ser Cys Arg Pro Asn Asp Val Thr Cys Val Phe Asp Pro 
            580                 585                 590         


Val His Thr Ile Ser His Thr Val Ile Ser Leu Pro Thr Phe Arg Glu 
        595                 600                 605             


Phe Thr Arg Pro Glu Glu Ile Ile Phe Leu Arg Ala Ile Thr Pro Pro 
    610                 615                 620                 


His Pro Ala Ser Gln Ala Asn Ile Ile Phe Asp Ile Thr Glu Gly Asn 
625                 630                 635                 640 


Leu Arg Asp Ser Phe Asp Ile Ile Lys Arg Tyr Met Asp Gly Met Thr 
                645                 650                 655     


Val Gly Val Val Arg Gln Val Arg Pro Ile Val Gly Pro Phe His Ala 
            660                 665                 670         


Val Leu Lys Leu Glu Met Asn Tyr Val Val Gly Gly Val Val Ser His 
        675                 680                 685             


Arg Asn Val Val Asn Val His Ile Phe Val Ser Glu Tyr Trp Phe 
    690                 695                 700             


<210>  14
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  15
<211>  935
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr 
    50                  55                  60                  


Lys Val Gln Ser Thr Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln 
65                  70                  75                  80  


Ser Lys Val Val Asn Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp 
                85                  90                  95      


Val Gln Ile Pro Lys Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val 
            100                 105                 110         


Asp Gly Lys Thr Phe Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg 
        115                 120                 125             


Ala Leu Tyr Ala Gln Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val 
    130                 135                 140                 


Arg Ser Ser Ala Leu Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val 
145                 150                 155                 160 


Leu Pro Gly Ala Lys Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys 
                165                 170                 175     


Trp Arg Lys Leu Gly Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly 
            180                 185                 190         


Arg Leu Ala Lys His Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln 
        195                 200                 205             


Gly Leu Arg Phe Leu His Val Pro Asp Thr Phe Glu Gly His Phe Asp 
    210                 215                 220                 


Gly Val Pro Val Ile Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe 
225                 230                 235                 240 


Lys Pro Thr Val Ala Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr 
                245                 250                 255     


Ala Val Asp Gly Glu Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu 
            260                 265                 270         


Lys Ala Gly Glu Leu Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe 
        275                 280                 285             


Ala Pro Asp Asn Leu Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile 
    290                 295                 300                 


Asp Val Ser Gly Ser Met Trp Gly Val Lys Met Lys Gln Thr Val Glu 
305                 310                 315                 320 


Ala Met Lys Thr Ile Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser 
                325                 330                 335     


Val Ile Asp Phe Asn Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile 
            340                 345                 350         


Ser Ala Thr Lys Thr Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys 
        355                 360                 365             


Ile Gln Pro Ser Gly Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala 
    370                 375                 380                 


Ile Phe Ile Leu Asn Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn 
385                 390                 395                 400 


Ser Val Ser Leu Ile Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly 
                405                 410                 415     


Glu Leu Lys Leu Ser Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln 
            420                 425                 430         


Asp Asn Ile Ser Leu Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr 
        435                 440                 445             


Asp Phe Leu Lys Arg Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg 
    450                 455                 460                 


Ile Tyr Gly Asn Gln Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn 
465                 470                 475                 480 


Gln Val Ser Thr Pro Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His 
                485                 490                 495     


Thr Ser Val Thr Asp Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly 
            500                 505                 510         


Gly Ser Glu Ile Val Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp 
        515                 520                 525             


Gln Ile Glu Ser Val Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val 
    530                 535                 540                 


Leu Glu Thr Leu Ala Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys 
545                 550                 555                 560 


Asp Lys His Ala Asp Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu 
                565                 570                 575     


Thr Ile Asn Gln Leu Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala 
            580                 585                 590         


Ala Lys Arg Arg Ile Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His 
        595                 600                 605             


His Ile Val Thr Pro Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly 
    610                 615                 620                 


Asp Glu Arg Met Leu Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys 
625                 630                 635                 640 


Ser Gly Ala Leu Tyr Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro 
                645                 650                 655     


Ser Trp Ala Asn Pro Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln 
            660                 665                 670         


Gly Ser Gln Val Leu Glu Ser Thr Pro Pro Pro His Val Met Arg Val 
        675                 680                 685             


Glu Asn Asp Pro His Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn 
    690                 695                 700                 


Ile Cys Phe Asn Ile Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val 
705                 710                 715                 720 


Ser Asp Pro Glu Ser Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala 
                725                 730                 735     


Lys Lys Pro Asn Asn Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly 
            740                 745                 750         


Phe Tyr Phe Gln Ser Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr 
        755                 760                 765             


Ile Thr Leu Ser His Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp 
    770                 775                 780                 


Thr Ala Gln Val Thr Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu 
785                 790                 795                 800 


Lys Val Val Thr Ile Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu 
                805                 810                 815     


Leu His Arg Val Trp Lys Lys His Pro Val Asn Val Asp Phe Leu Gly 
            820                 825                 830         


Ile Tyr Ile Pro Pro Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu 
        835                 840                 845             


Ile Gly Gln Phe Met Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg 
    850                 855                 860                 


Pro Gly Lys Asp Pro Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly 
865                 870                 875                 880 


Gln Lys Leu Ile Ile Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp 
                885                 890                 895     


Leu Val Phe Gly Thr Asp Val Thr Cys Trp Phe Val His Asn Ser Gly 
            900                 905                 910         


Lys Gly Phe Ile Asp Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu 
        915                 920                 925             


Tyr Ser Phe Leu Lys Arg Pro 
    930                 935 


<210>  16
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Ala Pro Gln Gln Glu Ala Leu Pro Asp Glu Thr Glu Val Val Glu 
            20                  25                  30          


Glu Thr Val Ala Glu Val Thr Glu Val Ser Val Gly Ala Asn Pro Val 
        35                  40                  45              


Gln Val Glu Val Gly Glu Phe Asp Asp Gly Ala Glu Glu Thr Glu Glu 
    50                  55                  60                  


Glu Val Val Ala Glu Asn Pro Cys Gln Asn His His Cys Lys His Gly 
65                  70                  75                  80  


Lys Val Cys Glu Leu Asp Glu Asn Asn Thr Pro Met Cys Val Cys Gln 
                85                  90                  95      


Asp Pro Thr Ser Cys Pro Ala Pro Ile Gly Glu Phe Glu Lys Val Cys 
            100                 105                 110         


Ser Asn Asp Asn Lys Thr Phe Asp Ser Ser Cys His Phe Phe Ala Thr 
        115                 120                 125             


Lys Cys Thr Leu Glu Gly Thr Lys Lys Gly His Lys Leu His Leu Asp 
    130                 135                 140                 


Tyr Ile Gly Pro Cys Lys Tyr Ile Pro Pro Cys Leu Asp Ser Glu Leu 
145                 150                 155                 160 


Thr Glu Phe Pro Leu Arg Met Arg Asp Trp Leu Lys Asn Val Leu Val 
                165                 170                 175     


Thr Leu Tyr Glu Arg Asp Glu Asp Asn Asn Leu Leu Thr Glu Lys Gln 
            180                 185                 190         


Lys Leu Arg Val Lys Lys Ile His Glu Asn Glu Lys Arg Leu Glu Ala 
        195                 200                 205             


Gly Asp His Pro Val Glu Leu Leu Ala Arg Asp Phe Glu Lys Asn Tyr 
    210                 215                 220                 


Asn Met Tyr Ile Phe Pro Val His Trp Gln Phe Gly Gln Leu Asp Gln 
225                 230                 235                 240 


His Pro Ile Asp Gly Tyr Leu Ser His Thr Glu Leu Ala Pro Leu Arg 
                245                 250                 255     


Ala Pro Leu Ile Pro Met Glu His Cys Thr Thr Arg Phe Phe Glu Thr 
            260                 265                 270         


Cys Asp Leu Asp Asn Asp Lys Tyr Ile Ala Leu Asp Glu Trp Ala Gly 
        275                 280                 285             


Cys Phe Gly Ile Lys Gln Lys Asp Ile Asp Lys Asp Leu Val Ile 
    290                 295                 300             


<210>  17
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  18
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210>  19
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gln Ser Val Gln Ser Thr Ser Phe Cys Leu Arg Lys Gln Cys Leu 
1               5                   10                  15      


Cys Leu Thr Phe Leu Leu Leu His Leu Leu Gly Gln Val Ala Ala Thr 
            20                  25                  30          


Gln Arg Cys Pro Pro Gln Cys Pro Gly Arg Cys Pro Ala Thr Pro Pro 
        35                  40                  45              


Thr Cys Ala Pro Gly Val Arg Ala Val Leu Asp Gly Cys Ser Cys Cys 
    50                  55                  60                  


Leu Val Cys Ala Arg Gln Arg Gly Glu Ser Cys Ser Asp Leu Glu Pro 
65                  70                  75                  80  


Cys Asp Glu Ser Ser Gly Leu Tyr Cys Asp Arg Ser Ala Asp Pro Ser 
                85                  90                  95      


Asn Gln Thr Gly Ile Cys Thr Ala Val Glu Gly Asp Asn Cys Val Phe 
            100                 105                 110         


Asp Gly Val Ile Tyr Arg Ser Gly Glu Lys Phe Gln Pro Ser Cys Lys 
        115                 120                 125             


Phe Gln Cys Thr Cys Arg Asp Gly Gln Ile Gly Cys Val Pro Arg Cys 
    130                 135                 140                 


Gln Leu Asp Val Leu Leu Pro Glu Pro Asn Cys Pro Ala Pro Arg Lys 
145                 150                 155                 160 


Val Glu Val Pro Gly Glu Cys Cys Glu Lys Trp Ile Cys Gly Pro Asp 
                165                 170                 175     


Glu Glu Asp Ser Leu Gly Gly Leu Thr Leu Ala Ala Tyr Arg Pro Glu 
            180                 185                 190         


Ala Thr Leu Gly Val Glu Val Ser Asp Ser Ser Val Asn Cys Ile Glu 
        195                 200                 205             


Gln Thr Thr Glu Trp Thr Ala Cys Ser Lys Ser Cys Gly Met Gly Phe 
    210                 215                 220                 


Ser Thr Arg Val Thr Asn Arg Asn Arg Gln Cys Glu Met Leu Lys Gln 
225                 230                 235                 240 


Thr Arg Leu Cys Met Val Arg Pro Cys Glu Gln Glu Pro Glu Gln Pro 
                245                 250                 255     


Thr Asp Lys Lys Gly Lys Lys Cys Leu Arg Thr Lys Lys Ser Leu Lys 
            260                 265                 270         


Ala Ile His Leu Gln Phe Lys Asn Cys Thr Ser Leu His Thr Tyr Lys 
        275                 280                 285             


Pro Arg Phe Cys Gly Val Cys Ser Asp Gly Arg Cys Cys Thr Pro His 
    290                 295                 300                 


Asn Thr Lys Thr Ile Gln Ala Glu Phe Gln Cys Ser Pro Gly Gln Ile 
305                 310                 315                 320 


Val Lys Lys Pro Val Met Val Ile Gly Thr Cys Thr Cys His Thr Asn 
                325                 330                 335     


Cys Pro Lys Asn Asn Glu Ala Phe Leu Gln Glu Leu Glu Leu Lys Thr 
            340                 345                 350         


Thr Arg Gly Lys Met 
        355         


<210>  20
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Val Arg Ala Arg His Gln Pro Gly Gly Leu Cys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gln Phe Met Glu Asp Arg Ser Ala Gln Ala Gly Asn Cys 
            20                  25                  30          


Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu Tyr Lys Thr 
        35                  40                  45              


Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu Ser Thr Ser 
    50                  55                  60                  


Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys Trp Met Ile 
65                  70                  75                  80  


Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr Cys Glu 
                85                  90                  95      


Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys Lys Asn 
            100                 105                 110         


Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys 
        115                 120                 125             


Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
    130                 135                 140                 


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
145                 150                 155                 160 


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
                165                 170                 175     


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
            180                 185                 190         


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
        195                 200                 205             


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
    210                 215                 220                 


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
225                 230                 235                 240 


Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
                245                 250                 255     


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
            260                 265                 270         


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
        275                 280                 285             


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
    290                 295                 300                 


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn Ser Ile Ser 
305                 310                 315                 320 


Glu Asp Thr Glu Glu Glu Glu Glu Asp Glu Asp Gln Asp Tyr Ser Phe 
                325                 330                 335     


Pro Ile Ser Ser Ile Leu Glu Trp 
            340                 


<210>  21
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  22
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ile Ile Leu Ile Tyr Leu Phe Leu Leu Leu Trp Glu Asp Thr Gln 
1               5                   10                  15      


Gly Trp Gly Phe Lys Asp Gly Ile Phe His Asn Ser Ile Trp Leu Glu 
            20                  25                  30          


Arg Ala Ala Gly Val Tyr His Arg Glu Ala Arg Ser Gly Lys Tyr Lys 
        35                  40                  45              


Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His 
    50                  55                  60                  


Leu Ala Thr Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His 
65                  70                  75                  80  


Val Cys Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile 
                85                  90                  95      


Val Lys Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp 
            100                 105                 110         


Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr 
        115                 120                 125             


Asn Pro His Ala Lys Glu Cys Gly Gly Val Phe Thr Asp Pro Lys Gln 
    130                 135                 140                 


Ile Phe Lys Ser Pro Gly Phe Pro Asn Glu Tyr Glu Asp Asn Gln Ile 
145                 150                 155                 160 


Cys Tyr Trp His Ile Arg Leu Lys Tyr Gly Gln Arg Ile His Leu Ser 
                165                 170                 175     


Phe Leu Asp Phe Asp Leu Glu Asp Asp Pro Gly Cys Leu Ala Asp Tyr 
            180                 185                 190         


Val Glu Ile Tyr Asp Ser Tyr Asp Asp Val His Gly Phe Val Gly Arg 
        195                 200                 205             


Tyr Cys Gly Asp Glu Leu Pro Asp Asp Ile Ile Ser Thr Gly Asn Val 
    210                 215                 220                 


Met Thr Leu Lys Phe Leu Ser Asp Ala Ser Val Thr Ala Gly Gly Phe 
225                 230                 235                 240 


Gln Ile Lys Tyr Val Ala Met Asp Pro Val Ser Lys Ser Ser Gln Gly 
                245                 250                 255     


Lys Asn Thr Ser Thr Thr Ser Thr Gly Asn Lys Asn Phe Leu Ala Gly 
            260                 265                 270         


Arg Phe Ser His Leu 
        275         


<210>  23
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Leu Phe Val Arg Leu Leu Ala Leu Ala Leu Ala Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ala Ala Thr Leu Ala Gly Pro Ala Lys Ser Pro Tyr Gln Leu 
            20                  25                  30          


Val Leu Gln His Ser Arg Leu Arg Gly Arg Gln His Gly Pro Asn Val 
        35                  40                  45              


Cys Ala Val Gln Lys Val Ile Gly Thr Asn Arg Lys Tyr Phe Thr Asn 
    50                  55                  60                  


Cys Lys Gln Trp Tyr Gln Arg Lys Ile Cys Gly Lys Ser Thr Val Ile 
65                  70                  75                  80  


Ser Tyr Glu Cys Cys Pro Gly Tyr Glu Lys Val Pro Gly Glu Lys Gly 
                85                  90                  95      


Cys Pro Ala Ala Leu Pro Leu Ser Asn Leu Tyr Glu Thr Leu Gly Val 
            100                 105                 110         


Val Gly Ser Thr Thr Thr Gln Leu Tyr Thr Asp Arg Thr Glu Lys Leu 
        115                 120                 125             


Arg Pro Glu Met Glu Gly Pro Gly Ser Phe Thr Ile Phe Ala Pro Ser 
    130                 135                 140                 


Asn Glu Ala Trp Ala Ser Leu Pro Ala Glu Val Leu Asp Ser Leu Val 
145                 150                 155                 160 


Ser Asn Val Asn Ile Glu Leu Leu Asn Ala Leu Arg Tyr His Met Val 
                165                 170                 175     


Gly Arg Arg Val Leu Thr Asp Glu Leu Lys His Gly Met Thr Leu Thr 
            180                 185                 190         


Ser Met Tyr Gln Asn Ser Asn Ile Gln Ile His His Tyr Pro Asn Gly 
        195                 200                 205             


Ile Val Thr Val Asn Cys Ala Arg Leu Leu Lys Ala Asp His His Ala 
    210                 215                 220                 


Thr Asn Gly Val Val His Leu Ile Asp Lys Val Ile Ser Thr Ile Thr 
225                 230                 235                 240 


Asn Asn Ile Gln Gln Ile Ile Glu Ile Glu Asp Thr Phe Glu Thr Leu 
                245                 250                 255     


Arg Ala Ala Val Ala Ala Ser Gly Leu Asn Thr Met Leu Glu Gly Asn 
            260                 265                 270         


Gly Gln Tyr Thr Leu Leu Ala Pro Thr Asn Glu Ala Phe Glu Lys Ile 
        275                 280                 285             


Pro Ser Glu Thr Leu Asn Arg Ile Leu Gly Asp Pro Glu Ala Leu Arg 
    290                 295                 300                 


Asp Leu Leu Asn Asn His Ile Leu Lys Ser Ala Met Cys Ala Glu Ala 
305                 310                 315                 320 


Ile Val Ala Gly Leu Ser Val Glu Thr Leu Glu Gly Thr Thr Leu Glu 
                325                 330                 335     


Val Gly Cys Ser Gly Asp Met Leu Thr Ile Asn Gly Lys Ala Ile Ile 
            340                 345                 350         


Ser Asn Lys Asp Ile Leu Ala Thr Asn Gly Val Ile His Tyr Ile Asp 
        355                 360                 365             


Glu Leu Leu Ile Pro Asp Ser Ala Lys Thr Leu Phe Glu Leu Ala Ala 
    370                 375                 380                 


Glu Ser Asp Val Ser Thr Ala Ile Asp Leu Phe Arg Gln Ala Gly Leu 
385                 390                 395                 400 


Gly Asn His Leu Ser Gly Ser Glu Arg Leu Thr Leu Leu Ala Pro Leu 
                405                 410                 415     


Asn Ser Val Phe Lys Asp Gly Thr Pro Pro Ile Asp Ala His Thr Arg 
            420                 425                 430         


Asn Leu Leu Arg Asn His Ile Ile Lys Asp Gln Leu Ala Ser Lys Tyr 
        435                 440                 445             


Leu Tyr His Gly Gln Thr Leu Glu Thr Leu Gly Gly Lys Lys Leu Arg 
    450                 455                 460                 


Val Phe Val Tyr Arg Asn Ser Leu Cys Ile Glu Asn Ser Cys Ile Ala 
465                 470                 475                 480 


Ala His Asp Lys Arg Gly Arg Tyr Gly Thr Leu Phe Thr Met Asp Arg 
                485                 490                 495     


Val Leu Thr Pro Pro Met Gly Thr Val Met Asp Val Leu Lys Gly Asp 
            500                 505                 510         


Asn Arg Phe Ser Met Leu Val Ala Ala Ile Gln Ser Ala Gly Leu Thr 
        515                 520                 525             


Glu Thr Leu Asn Arg Glu Gly Val Tyr Thr Val Phe Ala Pro Thr Asn 
    530                 535                 540                 


Glu Ala Phe Arg Ala Leu Pro Pro Arg Glu Arg Ser Arg Leu Leu Gly 
545                 550                 555                 560 


Asp Ala Lys Glu Leu Ala Asn Ile Leu Lys Tyr His Ile Gly Asp Glu 
                565                 570                 575     


Ile Leu Val Ser Gly Gly Ile Gly Ala Leu Val Arg Leu Lys Ser Leu 
            580                 585                 590         


Gln Gly Asp Lys Leu Glu Val Ser Leu Lys Asn Asn Val Val Ser Val 
        595                 600                 605             


Asn Lys Glu Pro Val Ala Glu Pro Asp Ile Met Ala Thr Asn Gly Val 
    610                 615                 620                 


Val His Val Ile Thr Asn Val Leu Gln Pro Pro Ala Asn Arg Pro Gln 
625                 630                 635                 640 


Glu Arg Gly Asp Glu Leu Ala Asp Ser Ala Leu Glu Ile Phe Lys Gln 
                645                 650                 655     


Ala Ser Ala Phe Ser Arg Ala Ser Gln Arg Ser Val Arg Leu Ala Pro 
            660                 665                 670         


Val Tyr Gln Lys Leu Leu Glu Arg Met Lys His 
        675                 680             


<210>  24
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  25
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln 
1               5                   10                  15      


Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln 
            20                  25                  30          


Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly 
        35                  40                  45              


Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu 
    50                  55                  60                  


Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile 
65                  70                  75                  80  


Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe 
                85                  90                  95      


Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln 
            100                 105                 110         


Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr 
        115                 120                 125             


Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe 
    130                 135                 140                 


Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg 
145                 150                 155                 160 


Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu 
                165                 170                 175     


Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala 
            180                 185         


<210>  26
<211>  225
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Xaa Gly Pro Ser Glu Arg Thr Leu Ser Ile Asn Glu Glu Glu Pro Glu 
1               5                   10                  15      


Gly Gly Phe Ser Lys Trp Asn Ala Thr Asn Lys Asp Pro Glu Glu Leu 
            20                  25                  30          


Phe Lys Gln Glu Met Pro Pro Arg Cys Ser Ser Pro Thr Val Gly Pro 
        35                  40                  45              


Pro Pro Leu Pro Gln Lys Ser Leu Glu Thr Arg Ala Gln Lys Lys Leu 
    50                  55                  60                  


Ser Cys Ser Leu Glu Asp Leu Arg Ser Glu Ser Val Asp Lys Cys Met 
65                  70                  75                  80  


Asp Gly Asn Gln Pro Phe Pro Val Leu Glu Pro Lys Asp Ser Pro Phe 
                85                  90                  95      


Leu Ala Glu His Lys Tyr Pro Thr Leu Pro Gly Lys Leu Ser Gly Ala 
            100                 105                 110         


Thr Pro Asn Gly Glu Ala Ala Lys Ser Pro Pro Thr Ile Cys Gln Pro 
        115                 120                 125             


Asp Ala Thr Gly Ser Ser Leu Leu Arg Leu Asn Arg Gly Arg Ser Val 
    130                 135                 140                 


Ser Ala Pro Val Leu Gly Asp Thr Glu Ser Gly Trp Asp Asp Thr Ala 
145                 150                 155                 160 


Val Val Asn Asp Leu Ser Ser Thr Ser Ser Gly Thr Glu Ser Gly Pro 
                165                 170                 175     


Gln Ser Pro Leu Thr Pro Asp Gly Lys Arg Asn Pro Lys Gly Ile Lys 
            180                 185                 190         


Lys Phe Trp Gly Lys Ile Arg Arg Thr Gln Ser Gly Asn Phe Tyr Thr 
        195                 200                 205             


Asp Thr Leu Gly Met Ala Glu Phe Arg Arg Gly Gly Leu Arg Ala Thr 
    210                 215                 220                 


Ala 
225 


<210>  27
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Xaa Gln Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp 
1               5                   10                  15      


Val Gly Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile 
            20                  25                  30          


Arg Gly Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys 
        35                  40                  45              


Phe Asp Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys 
    50                  55                  60                  


Ala His Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro 
65                  70                  75                  80  


Ala Ile Arg Glu Met Val Ser Gln Leu Gln Arg Glu Cys Tyr Leu Lys 
                85                  90                  95      


His Asp Leu Cys Ala Ala Ala Gln Glu Asn Thr Arg Val Ile Val Glu 
            100                 105                 110         


Met Ile His Phe Lys Asp Leu Leu Leu His Glu 
        115                 120             


<210>  28
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Gly Pro Leu Arg Ala Pro Leu Leu Leu Leu Ala Ile Leu Ala 
1               5                   10                  15      


Val Ala Leu Ala Val Ser Pro Ala Ala Gly Ser Ser Pro Gly Lys Pro 
            20                  25                  30          


Pro Arg Leu Val Gly Gly Pro Met Asp Ala Ser Val Glu Glu Glu Gly 
        35                  40                  45              


Val Arg Arg Ala Leu Asp Phe Ala Val Gly Glu Tyr Asn Lys Ala Ser 
    50                  55                  60                  


Asn Asp Met Tyr His Ser Arg Ala Leu Gln Val Val Arg Ala Arg Lys 
65                  70                  75                  80  


Gln Ile Val Ala Gly Val Asn Tyr Phe Leu Asp Val Glu Leu Gly Arg 
                85                  90                  95      


Thr Thr Cys Thr Lys Thr Gln Pro Asn Leu Asp Asn Cys Pro Phe His 
            100                 105                 110         


Asp Gln Pro His Leu Lys Arg Lys Ala Phe Cys Ser Phe Gln Ile Tyr 
        115                 120                 125             


Ala Val Pro Trp Gln Gly Thr Met Thr Leu Ser Lys Ser Thr Cys Gln 
    130                 135                 140                 


Asp Ala 
145     


<210>  29
<211>  1777
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Pro Arg Thr Lys Ala Arg Ser Pro Gly Arg Ala Leu Arg Asn 
1               5                   10                  15      


Pro Trp Arg Gly Phe Leu Pro Leu Thr Leu Ala Leu Phe Val Gly Ala 
            20                  25                  30          


Gly His Ala Gln Arg Asp Pro Val Gly Arg Tyr Glu Pro Ala Gly Gly 
        35                  40                  45              


Asp Ala Asn Arg Leu Arg Arg Pro Gly Gly Ser Tyr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Lys Val Tyr Ser Leu Phe Arg Glu Gln Asp Ala Pro Val Ala 
65                  70                  75                  80  


Gly Leu Gln Pro Val Glu Arg Ala Gln Pro Gly Trp Gly Ser Pro Arg 
                85                  90                  95      


Arg Pro Thr Glu Ala Glu Ala Arg Arg Pro Ser Arg Ala Gln Gln Ser 
            100                 105                 110         


Arg Arg Val Gln Pro Pro Ala Gln Thr Arg Arg Ser Thr Pro Leu Gly 
        115                 120                 125             


Gln Gln Gln Pro Ala Pro Arg Thr Arg Ala Ala Pro Ala Leu Pro Arg 
    130                 135                 140                 


Leu Gly Thr Pro Gln Arg Ser Gly Ala Ala Pro Pro Thr Pro Pro Arg 
145                 150                 155                 160 


Gly Arg Leu Thr Gly Arg Asn Val Cys Gly Gly Gln Cys Cys Pro Gly 
                165                 170                 175     


Trp Thr Thr Ala Asn Ser Thr Asn His Cys Ile Lys Pro Val Cys Glu 
            180                 185                 190         


Pro Pro Cys Gln Asn Arg Gly Ser Cys Ser Arg Pro Gln Leu Cys Val 
        195                 200                 205             


Cys Arg Ser Gly Phe Arg Gly Ala Arg Cys Glu Glu Val Ile Pro Asp 
    210                 215                 220                 


Glu Glu Phe Asp Pro Gln Asn Ser Arg Leu Ala Pro Arg Arg Trp Ala 
225                 230                 235                 240 


Glu Arg Ser Pro Asn Leu Arg Arg Ser Ser Ala Ala Gly Glu Gly Thr 
                245                 250                 255     


Leu Ala Arg Ala Gln Pro Pro Ala Pro Gln Ser Pro Pro Ala Pro Gln 
            260                 265                 270         


Ser Pro Pro Ala Gly Thr Leu Ser Gly Leu Ser Gln Thr His Pro Ser 
        275                 280                 285             


Gln Gln His Val Gly Leu Ser Arg Thr Val Arg Leu His Pro Thr Ala 
    290                 295                 300                 


Thr Ala Ser Ser Gln Leu Ser Ser Asn Ala Leu Pro Pro Gly Pro Gly 
305                 310                 315                 320 


Leu Glu Gln Arg Asp Gly Thr Gln Gln Ala Val Pro Leu Glu His Pro 
                325                 330                 335     


Ser Ser Pro Trp Gly Leu Asn Leu Thr Glu Lys Ile Lys Lys Ile Lys 
            340                 345                 350         


Ile Val Phe Thr Pro Thr Ile Cys Lys Gln Thr Cys Ala Arg Gly His 
        355                 360                 365             


Cys Ala Asn Ser Cys Glu Arg Gly Asp Thr Thr Thr Leu Tyr Ser Gln 
    370                 375                 380                 


Gly Gly His Gly His Asp Pro Lys Ser Gly Phe Arg Ile Tyr Phe Cys 
385                 390                 395                 400 


Gln Ile Pro Cys Leu Asn Gly Gly Arg Cys Ile Gly Arg Asp Glu Cys 
                405                 410                 415     


Trp Cys Pro Ala Asn Ser Thr Gly Lys Phe Cys His Leu Pro Ile Pro 
            420                 425                 430         


Gln Pro Asp Arg Glu Pro Pro Gly Arg Gly Ser Arg Pro Arg Ala Leu 
        435                 440                 445             


Leu Glu Ala Pro Leu Lys Gln Ser Thr Phe Thr Leu Pro Leu Ser Asn 
    450                 455                 460                 


Gln Leu Ala Ser Val Asn Pro Ser Leu Val Lys Val His Ile His His 
465                 470                 475                 480 


Pro Pro Glu Ala Ser Val Gln Ile His Gln Val Ala Gln Val Arg Gly 
                485                 490                 495     


Gly Val Glu Glu Ala Leu Val Glu Asn Ser Val Glu Thr Arg Pro Pro 
            500                 505                 510         


Pro Trp Leu Pro Ala Ser Pro Gly His Ser Leu Trp Asp Ser Asn Asn 
        515                 520                 525             


Ile Pro Ala Arg Ser Gly Glu Pro Pro Arg Pro Leu Pro Pro Ala Ala 
    530                 535                 540                 


Pro Arg Pro Arg Gly Leu Leu Gly Arg Cys Tyr Leu Asn Thr Val Asn 
545                 550                 555                 560 


Gly Gln Cys Ala Asn Pro Leu Leu Glu Leu Thr Thr Gln Glu Asp Cys 
                565                 570                 575     


Cys Gly Ser Val Gly Ala Phe Trp Gly Val Thr Leu Cys Ala Pro Cys 
            580                 585                 590         


Pro Pro Arg Pro Ala Ser Pro Val Ile Glu Asn Gly Gln Leu Glu Cys 
        595                 600                 605             


Pro Gln Gly Tyr Lys Arg Leu Asn Leu Thr His Cys Gln Asp Ile Asn 
    610                 615                 620                 


Glu Cys Leu Thr Leu Gly Leu Cys Lys Asp Ala Glu Cys Val Asn Thr 
625                 630                 635                 640 


Arg Gly Ser Tyr Leu Cys Thr Cys Arg Pro Gly Leu Met Leu Asp Pro 
                645                 650                 655     


Ser Arg Ser Arg Cys Val Ser Asp Lys Ala Ile Ser Met Leu Gln Gly 
            660                 665                 670         


Leu Cys Tyr Arg Ser Leu Gly Pro Gly Thr Cys Thr Leu Pro Leu Ala 
        675                 680                 685             


Gln Arg Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly Lys Ala 
    690                 695                 700                 


Trp Gly Ser Glu Cys Glu Lys Cys Pro Leu Pro Gly Thr Glu Ala Phe 
705                 710                 715                 720 


Arg Glu Ile Cys Pro Ala Gly His Gly Tyr Thr Tyr Ala Ser Ser Asp 
                725                 730                 735     


Ile Arg Leu Ser Met Arg Lys Ala Glu Glu Glu Glu Leu Ala Arg Pro 
            740                 745                 750         


Pro Arg Glu Gln Gly Gln Arg Ser Ser Gly Ala Leu Pro Gly Pro Ala 
        755                 760                 765             


Glu Arg Gln Pro Leu Arg Val Val Thr Asp Thr Trp Leu Glu Ala Gly 
    770                 775                 780                 


Thr Ile Pro Asp Lys Gly Asp Ser Gln Ala Gly Gln Val Thr Thr Ser 
785                 790                 795                 800 


Val Thr His Ala Pro Ala Trp Val Thr Gly Asn Ala Thr Thr Pro Pro 
                805                 810                 815     


Met Pro Glu Gln Gly Ile Ala Glu Ile Gln Glu Glu Gln Val Thr Pro 
            820                 825                 830         


Ser Thr Asp Val Leu Val Thr Leu Ser Thr Pro Gly Ile Asp Arg Cys 
        835                 840                 845             


Ala Ala Gly Ala Thr Asn Val Cys Gly Pro Gly Thr Cys Val Asn Leu 
    850                 855                 860                 


Pro Asp Gly Tyr Arg Cys Val Cys Ser Pro Gly Tyr Gln Leu His Pro 
865                 870                 875                 880 


Ser Gln Ala Tyr Cys Thr Asp Asp Asn Glu Cys Leu Arg Asp Pro Cys 
                885                 890                 895     


Lys Gly Lys Gly Arg Cys Ile Asn Arg Val Gly Ser Tyr Ser Cys Phe 
            900                 905                 910         


Cys Tyr Pro Gly Tyr Thr Leu Ala Thr Ser Gly Ala Thr Gln Glu Cys 
        915                 920                 925             


Gln Asp Ile Asn Glu Cys Glu Gln Pro Gly Val Cys Ser Gly Gly Gln 
    930                 935                 940                 


Cys Thr Asn Thr Glu Gly Ser Tyr His Cys Glu Cys Asp Gln Gly Tyr 
945                 950                 955                 960 


Ile Met Val Arg Lys Gly His Cys Gln Asp Ile Asn Glu Cys Arg His 
                965                 970                 975     


Pro Gly Thr Cys Pro Asp Gly Arg Cys Val Asn Ser Pro Gly Ser Tyr 
            980                 985                 990         


Thr Cys Leu Ala Cys Glu Glu Gly  Tyr Arg Gly Gln Ser  Gly Ser Cys 
        995                 1000                 1005             


Val Asp  Val Asn Glu Cys Leu  Thr Pro Gly Val Cys  Ala His Gly 
    1010                 1015                 1020             


Lys Cys  Thr Asn Leu Glu Gly  Ser Phe Arg Cys Ser  Cys Glu Gln 
    1025                 1030                 1035             


Gly Tyr  Glu Val Thr Ser Asp  Glu Lys Gly Cys Gln  Asp Val Asp 
    1040                 1045                 1050             


Glu Cys  Ala Ser Arg Ala Ser  Cys Pro Thr Gly Leu  Cys Leu Asn 
    1055                 1060                 1065             


Thr Glu  Gly Ser Phe Ala Cys  Ser Ala Cys Glu Asn  Gly Tyr Trp 
    1070                 1075                 1080             


Val Asn  Glu Asp Gly Thr Ala  Cys Glu Asp Leu Asp  Glu Cys Ala 
    1085                 1090                 1095             


Phe Pro  Gly Val Cys Pro Ser  Gly Val Cys Thr Asn  Thr Ala Gly 
    1100                 1105                 1110             


Ser Phe  Ser Cys Lys Asp Cys  Asp Gly Gly Tyr Arg  Pro Ser Pro 
    1115                 1120                 1125             


Leu Gly  Asp Ser Cys Glu Asp  Val Asp Glu Cys Glu  Asp Pro Gln 
    1130                 1135                 1140             


Ser Ser  Cys Leu Gly Gly Glu  Cys Lys Asn Thr Val  Gly Ser Tyr 
    1145                 1150                 1155             


Gln Cys  Leu Cys Pro Gln Gly  Phe Gln Leu Ala Asn  Gly Thr Val 
    1160                 1165                 1170             


Cys Glu  Asp Val Asn Glu Cys  Met Gly Glu Glu His  Cys Ala Pro 
    1175                 1180                 1185             


His Gly  Glu Cys Leu Asn Ser  His Gly Ser Phe Phe  Cys Leu Cys 
    1190                 1195                 1200             


Ala Pro  Gly Phe Val Ser Ala  Glu Gly Gly Thr Ser  Cys Gln Asp 
    1205                 1210                 1215             


Val Asp  Glu Cys Ala Thr Thr  Asp Pro Cys Val Gly  Gly His Cys 
    1220                 1225                 1230             


Val Asn  Thr Glu Gly Ser Phe  Asn Cys Leu Cys Glu  Thr Gly Phe 
    1235                 1240                 1245             


Gln Pro  Ser Pro Glu Ser Gly  Glu Cys Val Asp Ile  Asp Glu Cys 
    1250                 1255                 1260             


Ala Asn  Asp Thr Met Cys Gly  Ser His Gly Phe Cys  Asp Asn Thr 
    1265                 1270                 1275             


Asp Gly  Ser Phe Arg Cys Leu  Cys Asp Gln Gly Phe  Glu Ile Ser 
    1280                 1285                 1290             


Pro Ser  Gly Trp Asp Cys Val  Asp Val Asn Glu Cys  Glu Leu Met 
    1295                 1300                 1305             


Leu Ala  Val Cys Gly Ala Ala  Leu Cys Glu Asn Val  Glu Gly Ser 
    1310                 1315                 1320             


Phe Leu  Cys Leu Cys Ala Ser  Asp Leu Glu Glu Tyr  Asp Ala Gln 
    1325                 1330                 1335             


Glu Gly  His Cys Arg Pro Arg  Gly Ala Gly Gly Gln  Ser Met Ser 
    1340                 1345                 1350             


Glu Ala  Pro Thr Gly Asp His  Ala Pro Ala Pro Thr  Arg Met Asp 
    1355                 1360                 1365             


Cys Tyr  Ser Gly Gln Lys Gly  His Ala Pro Cys Ser  Ser Val Leu 
    1370                 1375                 1380             


Gly Arg  Asn Thr Thr Gln Ala  Glu Cys Cys Cys Thr  Gln Gly Ala 
    1385                 1390                 1395             


Ser Trp  Gly Asp Ala Cys Asp  Leu Cys Pro Ser Glu  Asp Ser Ala 
    1400                 1405                 1410             


Glu Phe  Ser Glu Ile Cys Pro  Ser Gly Lys Gly Tyr  Ile Pro Val 
    1415                 1420                 1425             


Glu Gly  Ala Trp Thr Phe Gly  Gln Thr Met Tyr Thr  Asp Ala Asp 
    1430                 1435                 1440             


Glu Cys  Val Ile Phe Gly Pro  Gly Leu Cys Pro Asn  Gly Arg Cys 
    1445                 1450                 1455             


Leu Asn  Thr Val Pro Gly Tyr  Val Cys Leu Cys Asn  Pro Gly Phe 
    1460                 1465                 1470             


His Tyr  Asp Ala Ser His Lys  Lys Cys Glu Asp His  Asp Glu Cys 
    1475                 1480                 1485             


Gln Asp  Leu Ala Cys Glu Asn  Gly Glu Cys Val Asn  Thr Glu Gly 
    1490                 1495                 1500             


Ser Phe  His Cys Phe Cys Ser  Pro Pro Leu Thr Leu  Asp Leu Ser 
    1505                 1510                 1515             


Gln Gln  Arg Cys Met Asn Ser  Thr Ser Ser Thr Glu  Asp Leu Pro 
    1520                 1525                 1530             


Asp His  Asp Ile His Met Asp  Ile Cys Trp Lys Lys  Val Thr Asn 
    1535                 1540                 1545             


Asp Val  Cys Ser Glu Pro Leu  Arg Gly His Arg Thr  Thr Tyr Thr 
    1550                 1555                 1560             


Glu Cys  Cys Cys Gln Asp Gly  Glu Ala Trp Ser Gln  Gln Cys Ala 
    1565                 1570                 1575             


Leu Cys  Pro Pro Arg Ser Ser  Glu Val Tyr Ala Gln  Leu Cys Asn 
    1580                 1585                 1590             


Val Ala  Arg Ile Glu Ala Glu  Arg Glu Ala Gly Val  His Phe Arg 
    1595                 1600                 1605             


Pro Gly  Tyr Glu Tyr Gly Pro  Gly Pro Asp Asp Leu  His Tyr Ser 
    1610                 1615                 1620             


Ile Tyr  Gly Pro Asp Gly Ala  Pro Phe Tyr Asn Tyr  Leu Gly Pro 
    1625                 1630                 1635             


Glu Asp  Thr Val Pro Glu Pro  Ala Phe Pro Asn Thr  Ala Gly His 
    1640                 1645                 1650             


Ser Ala  Asp Arg Thr Pro Ile  Leu Glu Ser Pro Leu  Gln Pro Ser 
    1655                 1660                 1665             


Glu Leu  Gln Pro His Tyr Val  Ala Ser His Pro Glu  Pro Pro Ala 
    1670                 1675                 1680             


Gly Phe  Glu Gly Leu Gln Ala  Glu Glu Cys Gly Ile  Leu Asn Gly 
    1685                 1690                 1695             


Cys Glu  Asn Gly Arg Cys Val  Arg Val Arg Glu Gly  Tyr Thr Cys 
    1700                 1705                 1710             


Asp Cys  Phe Glu Gly Phe Gln  Leu Asp Ala Ala His  Met Ala Cys 
    1715                 1720                 1725             


Val Asp  Val Asn Glu Cys Asp  Asp Leu Asn Gly Pro  Ala Val Leu 
    1730                 1735                 1740             


Cys Val  His Gly Tyr Cys Glu  Asn Thr Glu Gly Ser  Tyr Arg Cys 
    1745                 1750                 1755             


His Cys  Ser Pro Gly Tyr Val  Ala Glu Ala Gly Pro  Pro His Cys 
    1760                 1765                 1770             


Thr Ala  Lys Glu 
    1775         


<210>  30
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Glu Arg Pro Ser Leu Arg Ala Leu Leu Leu Gly Ala Ala Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Pro Leu Ser Ser Ser Ser Ser Ser Asp Thr Cys 
            20                  25                  30          


Gly Pro Cys Glu Pro Ala Ser Cys Pro Pro Leu Pro Pro Leu Gly Cys 
        35                  40                  45              


Leu Leu Gly Glu Thr Arg Asp Ala Cys Gly Cys Cys Pro Met Cys Ala 
    50                  55                  60                  


Arg Gly Glu Gly Glu Pro Cys Gly Gly Gly Gly Ala Gly Arg Gly Tyr 
65                  70                  75                  80  


Cys Ala Pro Gly Met Glu Cys Val Lys Ser Arg Lys Arg Arg Lys Gly 
                85                  90                  95      


Lys Ala Gly Ala Ala Ala Gly Gly Pro Gly Val Ser Gly Val Cys Val 
            100                 105                 110         


Cys Lys Ser Arg Tyr Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr Pro 
        115                 120                 125             


Ser Gly Cys Gln Leu Arg Ala Ala Ser Gln Arg Ala Glu Ser Arg Gly 
    130                 135                 140                 


Glu Lys Ala Ile Thr Gln Val Ser Lys Gly Thr Cys Glu Gln Gly Pro 
145                 150                 155                 160 


Ser Ile Val Thr Pro Pro Lys Asp Ile Trp Asn Val Thr Gly Ala Gln 
                165                 170                 175     


Val Tyr Leu Ser Cys Glu Val Ile Gly Ile Pro Thr Pro Val Leu Ile 
            180                 185                 190         


Trp Asn Lys Val Lys Arg Gly His Tyr Gly Val Gln Arg Thr Glu Leu 
        195                 200                 205             


Leu Pro Gly Asp Arg Asp Asn Leu Ala Ile Gln Thr Arg Gly Gly Pro 
    210                 215                 220                 


Glu Lys His Glu Val Thr Gly Trp Val Leu Val Ser Pro Leu Ser Lys 
225                 230                 235                 240 


Glu Asp Ala Gly Glu Tyr Glu Cys His Ala Ser Asn Ser Gln Gly Gln 
                245                 250                 255     


Ala Ser Ala Ser Ala Lys Ile Thr Val Val Asp Ala Leu His Glu Ile 
            260                 265                 270         


Pro Val Lys Lys Gly Glu Gly Ala Glu Leu 
        275                 280         


<210>  31
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  31
cagtgccagc ctcgtctcat ag                                                22


<210>  32
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  32
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgaccgttca caccga                                                       76


<210>  33
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  33
caagtgtctg ctactgagat gctc                                              24


<210>  34
<211>  77
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  34
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgaccagggc tatcttg                                                      77


<210>  35
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  35
tcccgaggag tcccaggata tg                                                22


<210>  36
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  36
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgacggcaga tggttg                                                       76


<210>  37
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  37
ccaccaatcc catccaaatt aacg                                              24


<210>  38
<211>  75
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  38
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgactccctg cgaag                                                        75


<210>  39
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  39
cagcagcgac tctgaagaag aac                                               23


<210>  40
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  40
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgaccctgac tcggac                                                       76


<210>  41
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  41
cagtgccagc ctcgtctcat ag                                                22


<210>  42
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  42
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgaccgttca caccga                                                       76


<210>  43
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  43
caagtgtctg ctactgagat gctc                                              24


<210>  44
<211>  77
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  44
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgaccagggc tatcttg                                                      77


<210>  45
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  45
tcccgaggag tcccaggata tg                                                22


<210>  46
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  46
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgacggcaga tggttg                                                       76


<210>  47
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  47
ccaccaatcc catccaaatt aacg                                              24


<210>  48
<211>  75
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  48
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgactccctg cgaag                                                        75


<210>  49
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  49
cagcagcgac tctgaagaag aac                                               23


<210>  50
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  50
gtcgtatcca gtgctgcgac cgtatggatg tgtctgcggc gttttatcat gcactggata       60

cgaccctgac tcggac                                                       76


