                         SEQUENCE LISTING

<110>  UCB BIOPHARMA SRL
 
<120>  MULTISPECIFIC ANTIBODIES

<130>  PF0207-WO-PCT

<140>  GB1919058.6
<141>  2019-12-20

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  1

Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  2

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  3

Asp Lys Thr His Thr Cys Ala Ala 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10      


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  6
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  6

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  9

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  10
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  10

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  11

Asp Lys Thr His Thr Cys Pro Ser Cys Pro Ala 
1               5                   10      


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  12

Ser Gly Gly Gly Gly Ser Glu 
1               5           


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  13

Asp Lys Thr His Thr Ser 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  14

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  15

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  16

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  17

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  18
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  18

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  19

Ala Ala Ala Gly Ser Gly Gly Ala Ser Ala Ser 
1               5                   10      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
1               5                   10                  15      


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ala Ser Ala Ser 
            20      


<210>  22
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25      


<210>  23
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25                  30      


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Ala Ala Ala Gly Ser Gly Xaa Ser Gly Ala Ser Ala Ser 
1               5                   10              


<210>  25
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  25

Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr Arg Arg Pro Ala Thr Thr 
1               5                   10                  15      


Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser His Tyr 
            20                  25              


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  26

Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr 
1               5                   10      


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  27

Ala Thr Thr Thr Gly Ser 
1               5       


<210>  28
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  28

Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Ser Pro Pro Ser Lys Glu 
1               5                   10                  15      


Ser His Lys Ser Pro 
            20      


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  29

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  30

Gly Gly Gly Gly Ile Ala Pro Ser Met Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  31

Gly Gly Gly Gly Lys Val Glu Gly Ala Gly Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  32

Gly Gly Gly Gly Ser Met Lys Ser His Asp Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  33

Gly Gly Gly Gly Asn Leu Ile Thr Ile Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  34

Gly Gly Gly Gly Val Val Pro Ser Leu Pro Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  35

Gly Gly Glu Lys Ser Ile Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  36
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  36

Arg Pro Leu Ser Tyr Arg Pro Pro Phe Pro Phe Gly Phe Pro Ser Val 
1               5                   10                  15      


Arg Pro 
        


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  37

Tyr Pro Arg Ser Ile Tyr Ile Arg Arg Arg His Pro Ser Pro Ser Leu 
1               5                   10                  15      


Thr Thr 
        


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  38

Thr Pro Ser His Leu Ser His Ile Leu Pro Ser Phe Gly Leu Pro Thr 
1               5                   10                  15      


Phe Asn 
        


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  39

Arg Pro Val Ser Pro Phe Thr Phe Pro Arg Leu Ser Asn Ser Trp Leu 
1               5                   10                  15      


Pro Ala 
        


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  40

Ser Pro Ala Ala His Phe Pro Arg Ser Ile Pro Arg Pro Gly Pro Ile 
1               5                   10                  15      


Arg Thr 
        


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  41

Ala Pro Gly Pro Ser Ala Pro Ser His Arg Ser Leu Pro Ser Arg Ala 
1               5                   10                  15      


Phe Gly 
        


<210>  42
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  42

Pro Arg Asn Ser Ile His Phe Leu His Pro Leu Leu Val Ala Pro Leu 
1               5                   10                  15      


Gly Ala 
        


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  43

Met Pro Ser Leu Ser Gly Val Leu Gln Val Arg Tyr Leu Ser Pro Pro 
1               5                   10                  15      


Asp Leu 
        


<210>  44
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  44

Ser Pro Gln Tyr Pro Ser Pro Leu Thr Leu Thr Leu Pro Pro His Pro 
1               5                   10                  15      


Ser Leu 
        


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  45

Asn Pro Ser Leu Asn Pro Pro Ser Tyr Leu His Arg Ala Pro Ser Arg 
1               5                   10                  15      


Ile Ser 
        


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  46

Leu Pro Trp Arg Thr Ser Leu Leu Pro Ser Leu Pro Leu Arg Arg Arg 
1               5                   10                  15      


Pro 
    


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  47

Pro Pro Leu Phe Ala Lys Gly Pro Val Gly Leu Leu Ser Arg Ser Phe 
1               5                   10                  15      


Pro Pro 
        


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  48

Val Pro Pro Ala Pro Val Val Ser Leu Arg Ser Ala His Ala Arg Pro 
1               5                   10                  15      


Pro Tyr 
        


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  49

Leu Arg Pro Thr Pro Pro Arg Val Arg Ser Tyr Thr Cys Cys Pro Thr 
1               5                   10                  15      


Pro 
    


<210>  50
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  50

Pro Asn Val Ala His Val Leu Pro Leu Leu Thr Val Pro Trp Asp Asn 
1               5                   10                  15      


Leu Arg 
        


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  51

Cys Asn Pro Leu Leu Pro Leu Cys Ala Arg Ser Pro Ala Val Arg Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rigid linker

<400>  52

Gly Ala Pro Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10      


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rigid linker

<400>  53

Pro Pro Pro Pro 
1               


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  54

Asp Leu Cys Leu Arg Asp Trp Gly Cys Leu Trp 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  55

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  56

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Gly Asp 
1               5                   10                  15  


<210>  57
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  57

Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Glu 
            20  


<210>  58
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  58

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val 
            20  


<210>  59
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  59

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val Lys 
            20      


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  60

Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15  


<210>  61
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  61

Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  62

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15      


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  63

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10                  15  


<210>  64
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  64

Arg Leu Met Glu Asp Ile Cys Leu Ala Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  65
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  65

Glu Val Arg Ser Phe Cys Thr Arg Trp Pro Ala Glu Lys Ser Cys Lys 
1               5                   10                  15      


Pro Leu Arg Gly 
            20  


<210>  66
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  66

Arg Ala Pro Glu Ser Phe Val Cys Tyr Trp Glu Thr Ile Cys Phe Glu 
1               5                   10                  15      


Arg Ser Glu Gln 
            20  


<210>  67
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin binding peptide

<400>  67

Glu Met Cys Tyr Phe Pro Gly Ile Cys Trp Met 
1               5                   10      


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  68

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  69
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  69

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  70

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 CDRH1

<400>  71

Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn 
1               5                   10  


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 CDRH2

<400>  72

Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  73
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 CDRH3

<400>  73

Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu 
1               5                   10              


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 CDRL1

<400>  74

Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser 
1               5                   10          


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 CDRL2

<400>  75

Glu Ala Ser Lys Leu Thr Ser 
1               5           


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 CDRL3

<400>  76

Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr 
1               5                   10      


<210>  77
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 heavy chain variable domain

<400>  77

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  78
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 heavy chain variable domain, mutated

<400>  78

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  79
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 light chain variable domain

<400>  79

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  80
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 645 light chain variable domain, mutated

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  81
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  645 scFv (VH-VL)

<400>  81

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu 
            180                 185                 190         


Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  82
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  645 dsscFv

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu 
            180                 185                 190         


Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr 
225                 230                 235                 240 


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
                245                 250     


