                         SEQUENCE LISTING

<110>  Evaxion Biotech ApS
 
<120>  NUCLEIC ACID VACCINATION USING NEO-EPITOPE ENCODING CONSTRUCTS

<130>  22220PCT00

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  2999
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pVAX1 DNA vaccine vector

<400>  1
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatatcca gcacagtggc      780

ggccgctcga gtctagaggg cccgtttaaa cccgctgatc agcctcgact gtgccttcta      840

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca      900

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc      960

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     1020

gcaggcatgc tggggatgcg gtgggctcta tggcttctac tgggcggttt tatggacagc     1080

aagcgaaccg gaattgccag ctggggcgcc ctctggtaag gttgggaagc cctgcaaagt     1140

aaactggatg gctttctcgc cgccaaggat ctgatggcgc aggggatcaa gctctgatca     1200

agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc     1260

ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc     1320

tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga     1380

cctgtccggt gccctgaatg aactgcaaga cgaggcagcg cggctatcgt ggctggccac     1440

gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct     1500

gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa     1560

agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc     1620

attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct     1680

tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc     1740

caggctcaag gcgagcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg     1800

cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct     1860

gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct     1920

tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca     1980

gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga attattaacg cttacaattt     2040

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tacaggtggc     2100

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     2160

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatagca cgtgctaaaa     2220

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     2280

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     2340

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     2400

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     2460

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     2520

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     2580

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     2640

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     2700

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     2760

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     2820

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     2880

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     2940

agcaacgcgg cctttttacg gttcctgggc ttttgctggc cttttgctca catgttctt      2999


<210>  2
<211>  6050
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pVAX1/LacZ DNA vaccine vector

<400>  2
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccactag tccagtgtgg tggaattctg cagatcgaaa cgatgataga      780

tcccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct      840

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc      900

ttcccaacag ttgcgcagcc tgaatggcga atggcgcttt gcctggtttc cggtaccaga      960

agcggtgccg gaaagctggc tggagtgcga tcttcctgag gccgatactg tcgtcgtccc     1020

ctcaaactgg cagatgcacg gttacgatgc gcccatctac accaacgtaa cctatcccat     1080

tacggtcaat ccgccgtttg ttcccacgga gaatccgacg ggttgttact cgctcacatt     1140

taatgttgat gaaagctggc tacaggaagg ccagacgcga attatttttg atggcgttaa     1200

ctcggcgttt catctgtggt gcaacgggcg ctgggtcggt tacggccagg acagtcgttt     1260

gccgtctgaa tttgacctga gcgcattttt acgcgccgga gaaaaccgcc tcgcggtgat     1320

ggtgctgcgt tggagtgacg gcagttatct ggaagatcag gatatgtggc ggatgagcgg     1380

cattttccgt gacgtctcgt tgctgcataa accgactaca caaatcagcg atttccatgt     1440

tgccactcgc tttaatgatg atttcagccg cgctgtactg gaggctgaag ttcagatgtg     1500

cggcgagttg cgtgactacc tacgggtaac agtttcttta tggcagggtg aaacgcaggt     1560

cgccagcggc accgcgcctt tcggcggtga aattatcgat gagcgtggtg gttatgccga     1620

tcgcgtcaca ctacgtctga acgtcgaaaa cccgaaactg tggagcgccg aaatcccgaa     1680

tctctatcgt gcggtggttg aactgcacac cgccgacggc acgctgattg aagcagaagc     1740

ctgcgatgtc ggtttccgcg aggtgcggat tgaaaatggt ctgctgctgc tgaacggcaa     1800

gccgttgctg attcgaggcg ttaaccgtca cgagcatcat cctctgcatg gtcaggtcat     1860

ggatgagcag acgatggtgc aggatatcct gctgatgaag cagaacaact ttaacgccgt     1920

gcgctgttcg cattatccga accatccgct gtggtacacg ctgtgcgacc gctacggcct     1980

gtatgtggtg gatgaagcca atattgaaac ccacggcatg gtgccaatga atcgtctgac     2040

cgatgatccg cgctggctac cggcgatgag cgaacgcgta acgcgaatgg tgcagcgcga     2100

tcgtaatcac ccgagtgtga tcatctggtc gctggggaat gaatcaggcc acggcgctaa     2160

tcacgacgcg ctgtatcgct ggatcaaatc tgtcgatcct tcccgcccgg tgcagtatga     2220

aggcggcgga gccgacacca cggccaccga tattatttgc ccgatgtacg cgcgcgtgga     2280

tgaagaccag cccttcccgg ctgtgccgaa atggtccatc aaaaaatggc tttcgctacc     2340

tggagagacg cgcccgctga tcctttgcga atacgcccac gcgatgggta acagtcttgg     2400

cggtttcgct aaatactggc aggcgtttcg tcagtatccc cgtttacagg gcggcttcgt     2460

ctgggactgg gtggatcagt cgctgattaa atatgatgaa aacggcaacc cgtggtcggc     2520

ttacggcggt gattttggcg atacgccgaa cgatcgccag ttctgtatga acggtctggt     2580

ctttgccgac cgcacgccgc atccagcgct gacggaagca aaacaccagc agcagttttt     2640

ccagttccgt ttatccgggc aaaccatcga agtgaccagc gaatacctgt tccgtcatag     2700

cgataacgag ctcctgcact ggatggtggc gctggatggt aagccgctgg caagcggtga     2760

agtgcctctg gatgtcgctc cacaaggtaa acagttgatt gaactgcctg aactaccgca     2820

gccggagagc gccgggcaac tctggctcac agtacgcgta gtgcaaccga acgcgaccgc     2880

atggtcagaa gccgggcaca tcagcgcctg gcagcagtgg cgtctggcgg aaaacctcag     2940

tgtgacgctc cccgccgcgt cccacgccat cccgcatctg accaccagcg aaatggattt     3000

ttgcatcgag ctgggtaata agcgttggca atttaaccgc cagtcaggct ttctttcaca     3060

gatgtggatt ggcgataaaa aacaactgct gacgccgctg cgcgatcagt tcacccgtgc     3120

accgctggat aacgacattg gcgtaagtga agcgacccgc attgacccta acgcctgggt     3180

cgaacgctgg aaggcggcgg gccattacca ggccgaagca gcgttgttgc agtgcacggc     3240

agatacactt gctgatgcgg tgctgattac gaccgctcac gcgtggcagc atcaggggaa     3300

aaccttattt atcagccgga aaacctaccg gattgatggt agtggtcaaa tggcgattac     3360

cgttgatgtt gaagtggcga gcgatacacc gcatccggcg cggattggcc tgaactgcca     3420

gctggcgcag gtagcagagc gggtaaactg gctcggatta gggccgcaag aaaactatcc     3480

cgaccgcctt actgccgcct gttttgaccg ctgggatctg ccattgtcag acatgtatac     3540

cccgtacgtc ttcccgagcg aaaacggtct gcgctgcggg acgcgcgaat tgaattatgg     3600

cccacaccag tggcgcggcg acttccagtt caacatcagc cgctacagtc aacagcaact     3660

gatggaaacc agccatcgcc atctgctgca cgcggaagaa ggcacatggc tgaatatcga     3720

cggtttccat atggggattg gtggcgacga ctcctggagc ccgtcagtat cggcggaatt     3780

ccagctgagc gccggtcgct accattacca gttggtctgg tgtcaaaaag cggccgctcg     3840

agtctagagg gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc     3900

catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg     3960

tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc     4020

tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg     4080

ctggggatgc ggtgggctct atggcttcta ctgggcggtt ttatggacag caagcgaacc     4140

ggaattgcca gctggggcgc cctctggtaa ggttgggaag ccctgcaaag taaactggat     4200

ggctttctcg ccgccaagga tctgatggcg caggggatca agctctgatc aagagacagg     4260

atgaggatcg tttcgcatga ttgaacaaga tggattgcac gcaggttctc cggccgcttg     4320

ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc     4380

cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg acctgtccgg     4440

tgccctgaat gaactgcaag acgaggcagc gcggctatcg tggctggcca cgacgggcgt     4500

tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg     4560

cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat     4620

catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca     4680

ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca     4740

ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa     4800

ggcgagcatg cccgacggcg aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa     4860

tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc tgggtgtggc     4920

ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga     4980

atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc agcgcatcgc     5040

cttctatcgc cttcttgacg agttcttctg aattattaac gcttacaatt tcctgatgcg     5100

gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg     5160

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     5220

ctcatgagac aataaccctg ataaatgctt caataatagc acgtgctaaa acttcatttt     5280

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     5340

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     5400

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     5460

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     5520

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     5580

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     5640

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     5700

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     5760

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     5820

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     5880

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     5940

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     6000

gcctttttac ggttcctggg cttttgctgg ccttttgctc acatgttctt                6050


<210>  3
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker peptide

<400>  3

Gly Ser Gly Gly Gly Ala 
1               5       


<210>  4
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Flexible linker peptide

<400>  4

Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly Gly Ala 
1               5                   10          


<210>  5
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker peptide

<400>  5

Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ala 
        


<210>  6
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker peptide

<400>  6

Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly Gly Ala Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ala Gly Ser Gly Gly Gly Ala 
            20                  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker peptide

<400>  7

Gly Glu Asn Leu Tyr Phe Gln Ser Gly Gly 
1               5                   10  


<210>  8
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker peptide

<400>  8

Lys Pro Glu Pro Lys Pro Ala Pro Ala Pro Lys Pro 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker peptide

<400>  9

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  10
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker peptide

<400>  10

Ser Ala Cys Tyr Cys Glu Leu Ser 
1               5               


<210>  11
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Neo-epitope

<400>  11

Gln Ile Glu Thr Gln Gln Arg Lys Phe Lys Ala Ser Arg Ala Ser Ile 
1               5                   10                  15      


Leu Ser Glu Met Lys Met Leu Lys Glu Lys Arg 
            20                  25          


<210>  12
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Neo-epitope

<400>  12

Val Ile Leu Pro Gln Ala Pro Ser Gly Pro Ser Tyr Ala Thr Tyr Leu 
1               5                   10                  15      


Gln Pro Ala Gln Ala Gln Met Leu Thr Pro Pro 
            20                  25          


<210>  13
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Neo-epitope

<400>  13

Asp Thr Leu Ser Ala Met Ser Asn Pro Arg Ala Met Gln Val Leu Leu 
1               5                   10                  15      


Gln Ile Gln Gln Gly Leu Gln Thr Leu Ala Thr 
            20                  25          


<210>  14
<211>  27
<212>  PRT
<213>  Artificial sequene

<220>
<223>  Neo-epitope

<400>  14

Asp Gly Gln Leu Glu Leu Leu Ala Gln Gly Ala Leu Asp Asn Ala Leu 
1               5                   10                  15      


Ser Ser Met Gly Ala Leu His Ala Leu Pro Arg 
            20                  25          


<210>  15
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Neo-epitope

<400>  15

Arg Leu His Val Val Lys Leu Leu Ala Ser Ala Leu Ser Thr Asn Ala 
1               5                   10                  15      


Ala Ala Leu Thr Gln Glu Leu Leu Val Leu Asp 
            20                  25          


<210>  16
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  16

Ser Gly Gly Gly Ser Ser Gly Gly Gly Ser 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  18

Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  19

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial seuence

<220>
<223>  Peptide linker

<400>  20

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  21
ggggtcaacg ttgagggggg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  22
gggggacgat cgtcgggggg                                                   20


<210>  23
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  23
ggggacgacg tcgtgggggg g                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  24
tccatgacgt tcctgatgct                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  25
tccatgacgt tcctgacgtt                                                   20


<210>  26
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  26
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  27
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  27
tcgtcgttgt cgttttgtcg tt                                                22


<210>  28
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  28
tcgacgttcg tcgttcgtcg ttc                                               23


<210>  29
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  29
tcgcgacgtt cgcccgacgt tcggta                                            26


<210>  30
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  30
tcgtcgtttt cggcgcgcgc cg                                                22


<210>  31
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  31
tcgtcgtcgt tcgaacgacg ttgat                                             25


<210>  32
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CpG motif

<400>  32
tcgcgaacgt tcgccgcgtt cgaacgcgg                                         29


<210>  33
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fragment of pTVG4 vaccine vector

<400>  33
agatctaacg acaaaacgac aaaacgacaa ggcgccagat ctggcgtttc gttttgtcgt       60

tttgtcgtta gatct                                                        75


<210>  34
<211>  4099
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pTVG4 vaccine vector

<400>  34
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcagtcacc gtcgtcgacg     1080

gtatcgataa gcttgatatc gaattcacgt gggcccggta ccgtatactc tagagcggcc     1140

gcggatccag atctaacgac aaaacgacaa aacgacaagg cgccagatct ggcgtttcgt     1200

tttgtcgttt tgtcgttaga tctttttccc tctgccaaaa attatgggga catcatgaag     1260

ccccttgagc atctgacttc tggctaataa aggaaattta ttttcattgc aatagtgtgt     1320

tggaattttt tgtgtctctc actcggaagg acatatggga gggcaaatca tttaaaacat     1380

cagaatgagt atttggttta gagtttggca acatatgccc attcttccgc ttcctcgctc     1440

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     1500

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     1560

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     1620

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     1680

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     1740

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     1800

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     1860

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     1920

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     1980

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     2040

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     2100

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     2160

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     2220

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     2280

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     2340

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     2400

atctgtctat ttcgttcatc catagttgcc tgactcgggg ggggggggcg ctgaggtctg     2460

cctcgtgaag aaggtgttgc tgactcatac caggcctgaa tcgccccatc atccagccag     2520

aaagtgaggg agccacggtt gatgagagct ttgttgtagg tggaccagtt ggtgattttg     2580

aacttttgct ttgccacgga acggtctgcg ttgtcgggaa gatgcgtgat ctgatccttc     2640

aactcagcaa aagttcgatt tattcaacaa agccgccgtc ccgtcaagtc agcgtaatgc     2700

tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa aaactcatcg agcatcaaat     2760

gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa agccgtttct     2820

gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc tggtatcggt     2880

ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg tcaaaaataa     2940

ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat ggcaaaagct     3000

tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca tcaaaatcac     3060

tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga aatacgcgat     3120

cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg aacactgcca     3180

gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg aatgctgttt     3240

tcccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata aaatgcttga     3300

tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca tctgtaacat     3360

cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg ggcttcccat     3420

acaatcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat ttatacccat     3480

ataaatcagc atccatgttg gaatttaatc gcggcctcga gcaagacgtt tcccgttgaa     3540

tatggctcat aacacccctt gtattactgt ttatgtaagc agacagtttt attgttcatg     3600

atgatatatt tttatcttgt gcaatgtaac atcagagatt ttgagacaca acgtggcttt     3660

cccccccccc ccattattga agcatttatc agggttattg tctcatgagc ggatacatat     3720

ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc     3780

cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat aggcgtatca     3840

cgaggccctt tcgtctcgcg cgtttcggtg atgacggtga aaacctctga cacatgcagc     3900

tcccggagac ggtcacagct tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg     3960

gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa ctatgcggca tcagagcaga     4020

ttgtactgag agtgcaccat atgcggtgtg aaataccgca cagatgcgta aggagaaaat     4080

accgcatcag attggctat                                                  4099


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CPG encoding sequence

<400>  35
ggtgcatcga tgcagggggg                                                   20


<210>  36
<211>  83
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CPG encoding sequence

<400>  36
ggtgcatcga tgcagggggg tatatatata ttgaggacag gttaagctcc ccccagctta       60

acctgtcctt caatatatat ata                                               83


