                         SEQUENCE LISTING

<110>  Intervet Inc.
       Intervet International, BV
       Merck & Co.
       Morsey, Mohamad
       Zhang, Yuanzheng
       Saha, Anasuya
 
<120>  BISPECIFIC CANINIZED ANTIBODIES FOR TREATING ATOPIC DERMATITIS

<130>  24936

<150>  US 62/951,778
<151>  2019-12-20

<150>  US 62/951,793
<151>  2019-12-20

<150>  US 63/015,209
<151>  2020-04-24

<150>  US 63/015,220
<151>  2020-04-24

<150>  US 63/092,294
<151>  2020-10-15

<150>  US 63/092,296
<151>  2020-10-15

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and HIS Tag

<400>  1

Leu Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Asn Met Gly Glu Arg Cys Tyr Leu Met Lys Glu Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Leu Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Lys Leu 
                85                  90                  95      


Ser Gln Cys His Ile Glu Asn Asp Asp Gln His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Gln Lys Leu Gly Glu Asn Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ala Leu Arg Asn Ala 
    130                 135                 140                 


Cys Val His His His His His His 
145                 150         


<210>  2
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Thr Gly Ser Ala Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Glu Lys Phe Asp Ser Asp Asp Ser Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  3
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  4
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and mouse

<400>  4

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Leu Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Glu Phe Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  5
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and mouse

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Asp Lys Arg Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Gly Gly Asp Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Leu Asn Asn Arg Gly Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly 
    450             


<210>  6
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and mouse

<400>  6

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Tyr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Glu Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Glu Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Asn Tyr 
                85                  90                  95      


Glu Asn Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
            180                 185                 190         


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
        195                 200                 205             


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220     


<210>  7
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and mouse

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Arg Tyr 
            20                  25                  30          


Trp Met His Trp Met Lys Gln Ala Pro Gly Ala Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asp Ser Gly Asn Ile Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Arg Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  8
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  canine and HIS Tag

<400>  8
gtgctgcccg ccaagcccga gaacatcagc tgcatcttct actacgagga gaacttcacc       60

tgcacctgga gccccgagaa ggaggccagc tacacctggt acaaggtgaa gagaacctac      120

agctacggct acaagagcga catctgcagc accgacaaca gcaccagagg caaccacgcc      180

agctgcagct tcctgccccc caccatcacc aaccccgaca actacaccat ccaggtggag      240

gcccagaacg ccgacggcat catgaagagc gacatcacct actggaacct ggacgccatc      300

atgaagatcg agccccccga gatcttcagc gtgaagagcg tgctgggcat caagagaatg      360

ctgcagatca agtggatcag acccgtgctg gccccccaca gcagcaccct gaagtacacc      420

ctgagattca gaaccatcaa cagcgcctac tggatggagg tgaacttcac caaggaggac      480

atcgacagag acgagaccta caacctgacc gagctgcagg ccttcaccga gtacgtgatg      540

accctgagat gcgcccccgc cgagagcatg ttctggagcg gctggagcca ggagaaggtg      600

ggcaccaccg aggaggaggc cccctacggc ctggacctgt ggagagtgct gaagcccgcc      660

atggtggacg gcagaagacc cgtgcagctg atgtggaaga aggccaccgg cgcccccgtg      720

ctggagaagg ccctgggcta caacatctgg tacttccccg agaacaacac caacctgacc      780

gagaccgtga acaccaccaa ccagacccac gagctgtacc tgggcggcaa gacctactgg      840

gtgtacgtgg tgagctacaa cagcctgggc gagagccccg tggccaccct gagaatcccc      900

gccctgaacg agaagacctt ccagtgcatc gaggccatgc aggcctgcct gacccaggac      960

cagctggtgg tggagtggca gagcagcgcc cccgaggtgg acacctggat ggtggagtgg     1020

ttccccgacg tggacagcga gcccagcagc ttcagctggg agagcgtgag ccaggccaga     1080

aactggacca tccagaagga cgagctgaag cccctgtggt gctacaacat cagcgtgtac     1140

cccgtgctga gagacagagt gggccagccc tacagcaccc aggcctacgt gcaggagggc     1200

atccccagcg ccggccccgt gacccaggcc gacagcatcg gcgtgaagac cgtgaccatc     1260

acctggaagg agatccccaa gagcaagaga aacggcttca tcaagaacta caccatcttc     1320

taccaggccg aggacggcaa ggagttcagc aagaccgtga acagcaacat cctgcagtac     1380

agactggaga gcctgaccag aagaaccagc tacagcctgc aggtgatggc cagcaccaac     1440

gccggcggca ccaacggcac caagatcaac ttcaagaccc tgagcatcag ccaccaccac     1500

caccaccacc accaccacca c                                               1521


<210>  9
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and HIS Tag

<400>  9

Val Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Ile Phe Tyr Tyr Glu 
1               5                   10                  15      


Glu Asn Phe Thr Cys Thr Trp Ser Pro Glu Lys Glu Ala Ser Tyr Thr 
            20                  25                  30          


Trp Tyr Lys Val Lys Arg Thr Tyr Ser Tyr Gly Tyr Lys Ser Asp Ile 
        35                  40                  45              


Cys Ser Thr Asp Asn Ser Thr Arg Gly Asn His Ala Ser Cys Ser Phe 
    50                  55                  60                  


Leu Pro Pro Thr Ile Thr Asn Pro Asp Asn Tyr Thr Ile Gln Val Glu 
65                  70                  75                  80  


Ala Gln Asn Ala Asp Gly Ile Met Lys Ser Asp Ile Thr Tyr Trp Asn 
                85                  90                  95      


Leu Asp Ala Ile Met Lys Ile Glu Pro Pro Glu Ile Phe Ser Val Lys 
            100                 105                 110         


Ser Val Leu Gly Ile Lys Arg Met Leu Gln Ile Lys Trp Ile Arg Pro 
        115                 120                 125             


Val Leu Ala Pro His Ser Ser Thr Leu Lys Tyr Thr Leu Arg Phe Arg 
    130                 135                 140                 


Thr Ile Asn Ser Ala Tyr Trp Met Glu Val Asn Phe Thr Lys Glu Asp 
145                 150                 155                 160 


Ile Asp Arg Asp Glu Thr Tyr Asn Leu Thr Glu Leu Gln Ala Phe Thr 
                165                 170                 175     


Glu Tyr Val Met Thr Leu Arg Cys Ala Pro Ala Glu Ser Met Phe Trp 
            180                 185                 190         


Ser Gly Trp Ser Gln Glu Lys Val Gly Thr Thr Glu Glu Glu Ala Pro 
        195                 200                 205             


Tyr Gly Leu Asp Leu Trp Arg Val Leu Lys Pro Ala Met Val Asp Gly 
    210                 215                 220                 


Arg Arg Pro Val Gln Leu Met Trp Lys Lys Ala Thr Gly Ala Pro Val 
225                 230                 235                 240 


Leu Glu Lys Ala Leu Gly Tyr Asn Ile Trp Tyr Phe Pro Glu Asn Asn 
                245                 250                 255     


Thr Asn Leu Thr Glu Thr Val Asn Thr Thr Asn Gln Thr His Glu Leu 
            260                 265                 270         


Tyr Leu Gly Gly Lys Thr Tyr Trp Val Tyr Val Val Ser Tyr Asn Ser 
        275                 280                 285             


Leu Gly Glu Ser Pro Val Ala Thr Leu Arg Ile Pro Ala Leu Asn Glu 
    290                 295                 300                 


Lys Thr Phe Gln Cys Ile Glu Ala Met Gln Ala Cys Leu Thr Gln Asp 
305                 310                 315                 320 


Gln Leu Val Val Glu Trp Gln Ser Ser Ala Pro Glu Val Asp Thr Trp 
                325                 330                 335     


Met Val Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Ser Ser Phe Ser 
            340                 345                 350         


Trp Glu Ser Val Ser Gln Ala Arg Asn Trp Thr Ile Gln Lys Asp Glu 
        355                 360                 365             


Leu Lys Pro Leu Trp Cys Tyr Asn Ile Ser Val Tyr Pro Val Leu Arg 
    370                 375                 380                 


Asp Arg Val Gly Gln Pro Tyr Ser Thr Gln Ala Tyr Val Gln Glu Gly 
385                 390                 395                 400 


Ile Pro Ser Ala Gly Pro Val Thr Gln Ala Asp Ser Ile Gly Val Lys 
                405                 410                 415     


Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Lys Arg Asn Gly 
            420                 425                 430         


Phe Ile Lys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Asp Gly Lys Glu 
        435                 440                 445             


Phe Ser Lys Thr Val Asn Ser Asn Ile Leu Gln Tyr Arg Leu Glu Ser 
    450                 455                 460                 


Leu Thr Arg Arg Thr Ser Tyr Ser Leu Gln Val Met Ala Ser Thr Asn 
465                 470                 475                 480 


Ala Gly Gly Thr Asn Gly Thr Lys Ile Asn Phe Lys Thr Leu Ser Ile 
                485                 490                 495     


Ser His His His His His His His His His His 
            500                 505         


<210>  10
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and mouse

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Trp Asp Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Trp Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  11
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and mouse

<400>  11

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Thr Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Gln Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Trp Cys Leu Leu Asn Ser Phe Tyr Pro 
    130                 135                 140                 


Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr 
145                 150                 155                 160 


Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu 
            180                 185                 190         


Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile 
        195                 200                 205             


Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220 


<210>  12
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and mouse

<400>  12

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
            180                 185                 190         


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
        195                 200                 205             


Ile Lys Ser Phe Gln Arg Ser Glu Cys 
    210                 215         


<210>  13
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and mouse

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly 
    450         


<210>  14
<211>  215
<212>  PRT
<213>  Canis familiaris

<400>  14

Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
1               5                   10                  15      


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            20                  25                  30          


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        35                  40                  45              


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    50                  55                  60                  


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
65                  70                  75                  80  


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                85                  90                  95      


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            100                 105                 110         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        115                 120                 125             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    130                 135                 140                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
145                 150                 155                 160 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                165                 170                 175     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            180                 185                 190         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        195                 200                 205             


Leu Ser His Ser Pro Gly Lys 
    210                 215 


<210>  15
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and mouse

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Asn Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Trp Asp Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Trp Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Cys Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  16
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and mouse

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Cys Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
        355                 360                 365             


Leu Trp Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly 
    450         


<210>  17
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and human

<400>  17

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Thr Gly Ser Ala Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Glu Lys Phe Asp Ser Asp Asp Ser Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Cys Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Trp Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly 
    450                 455 


<210>  18
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and mouse

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Asp Lys Arg Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Gly Gly Asp Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Leu Asn Asn Arg Gly Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Cys Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Ser Cys Ala Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Val Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly 
    450             


<210>  19
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and mouse

<400>  19

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Arg Tyr 
            20                  25                  30          


Trp Met His Trp Met Lys Gln Ala Pro Gly Ala Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asp Ser Gly Asn Ile Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Arg Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Cys 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Val Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  20
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and human

<400>  20

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Ala Val Leu Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Gly Val His Trp Tyr Gln Gln Leu Pro Gly Lys Ser Pro Lys Thr 
        35                  40                  45              


Ile Ile Tyr Gly Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Thr Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gly Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Ser Gly Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Thr Gln Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Asp Lys Trp Lys Ser 
            180                 185                 190         


His Ser Ser Phe Ser Cys Leu Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Lys Val Ala Pro Ala Glu Cys Ser 
    210                 215         


<210>  21
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and human

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Thr Gly Ser Ala Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Glu Lys Phe Asp Ser Asp Asp Ser Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly 
    450                 455 


<210>  22
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and human

<400>  22

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Ala Val Leu Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Gly Val His Trp Tyr Gln Gln Leu Pro Gly Lys Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Thr Ala Ser Leu Thr Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gly Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Ser Gly Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Thr Gln Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Asp Lys Trp Lys Ser 
            180                 185                 190         


His Ser Ser Phe Ser Cys Leu Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Lys Val Ala Pro Ala Glu Cys Ser 
    210                 215         


<210>  23
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and human

<400>  23

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Thr Gly Ser Ala Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Glu Lys Phe Asp Ser Asp Asp Ser Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly 
    450                 455 


<210>  24
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and human

<400>  24

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Phe Leu Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Gly Val His Trp Tyr Gln Gln Leu Pro Gly Thr Gly Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gly Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Ser Gly Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Thr Gln Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Asp Lys Trp Lys Ser 
            180                 185                 190         


His Ser Ser Phe Ser Cys Leu Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Lys Val Ala Pro Ala Glu Cys Ser 
    210                 215         


<210>  25
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and human

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Thr Gly Ser Ala Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Pro Glu Lys Phe Asp Ser Asp Asp Ser Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly 
    450                 455 


<210>  26
<211>  17
<212>  PRT
<213>  Canis familiaris

<400>  26

Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Pro 
    


<210>  27
<211>  22
<212>  PRT
<213>  Canis familiaris

<400>  27

Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Met 
            20          


<210>  28
<211>  20
<212>  PRT
<213>  Canis familiaris

<400>  28

Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro 
1               5                   10                  15      


Gly Cys Gly Leu 
            20  


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine

<400>  29

Pro Lys Glu Ser Thr Cys Lys Cys Ile Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Ser 
    


<210>  30
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  30

Asn Tyr Tyr Met His 
1               5   


<210>  31
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  31
aactattata tgcat                                                        15


<210>  32
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  32

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Gly Val His 
1               5                   10                  


<210>  33
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  33
accggcagca gcagcaacat tggcgcgggc tatggcgtgc at                          42


<210>  34
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  34

Trp Ile Asn Pro Tyr Thr Gly Ser Ala Phe Tyr Ala Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  35
tggattaacc cgtataccgg cagcgcgttt tatgcgcaga aatttcgcgg c                51


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Asp Ser Asn Arg Pro Ser 
1               5           


<210>  37
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  37
ggcgatagca accgcccgag c                                                 21


<210>  38
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Pro Glu Lys Phe Asp Ser Asp Asp Ser Asp Val 
1               5                   10          


<210>  39
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  39
gaaccggaaa aatttgatag cgatgatagc gatgtg                                 36


<210>  40
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Ser Tyr Asp Asn Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  41
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  41
cagagctatg cagagctatg ataacagcct gagcggctat gtgataacag cctgagcggc       60

tatgtg                                                                  66


<210>  42
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and rat

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Gly Thr Leu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  43
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canine and rat

<400>  43

Gln Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Ala Ser Leu Gly Thr 
1               5                   10                  15      


Thr Ala Arg Leu Thr Cys Glu Arg Ser Ser Gly Asp Ile Gly Asp Ser 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Arg Asp Leu 
        35                  40                  45              


Leu Tyr Val Asp Asp Gln Arg Pro Ser Gly Val Ser Lys Ser Phe Ser 
    50                  55                  60                  


Gly Ser Lys Asp Thr Ser Ala Asn Ala Gly Leu Leu Leu Ile Ser Gly 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Asn Ile Asp Gly Pro Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gly Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Ser Gly Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
145                 150                 155                 160 


Val Thr Gln Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Asp Lys Trp Lys 
            180                 185                 190         


Ser His Ser Ser Phe Ser Cys Leu Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Lys Val Ala Pro Ala Glu Cys Ser 
    210                 215             


<210>  44
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine and rat

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Gly Thr Leu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Cys Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Trp Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified canine

<400>  45

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr Thr 
1               5                   10                  15      


Ala Pro Ser Val 
            20  


<210>  46
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified canne

<400>  46

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Asp Ala Gln 
1               5                   10                  15      


Pro Ala Val 
            


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified canine

<400>  47

Phe Gly Gln Gly Thr Lys Val Glu Ser Lys Ser Ser Ala Ser Thr Thr 
1               5                   10                  15      


Ala Pro Ser Val 
            20  


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified canine

<400>  48

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Arg Asn Asp Ala Gln 
1               5                   10                  15      


Pro Ala Val 
            


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified canine

<400>  49

Phe Gly Gly Gly Thr His Leu Thr Val Leu Ser Ser Ala Ser Thr Thr 
1               5                   10                  15      


Ala Pro Ser Val 
            20  


<210>  50
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified canine

<400>  50

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gln Pro Lys Ala 
1               5                   10                  15      


Ser Pro 
        


