                         SEQUENCE LISTING

<110>  Intervet Inc.
       Morsey, Mohamad
       Zhang, Yuanzheng
 
<120>   CANINE INTERLEUKIN-4 RECEPTOR ALPHA ANTIBODIES

<130>  24981

<150>  63/015,220
<151>  2020-04-24

<150>  63/015,209
<151>  2020-04-24

<150>  62/951,793
<151>  2019-12-20

<150>  62/951,778
<151>  2019-12-20

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  2469
<212>  DNA
<213>  Canis familiaris

<400>  1
atgggcagac tgtgcagcgg cctgaccttc cccgtgagct gcctggtgct ggtgtgggtg       60

gccagcagcg gcagcgtgaa ggtgctgcac gagcccagct gcttcagcga ctacatcagc      120

accagcgtgt gccagtggaa gatggaccac cccaccaact gcagcgccga gctgagactg      180

agctaccagc tggacttcat gggcagcgag aaccacacct gcgtgcccga gaacagagag      240

gacagcgtgt gcgtgtgcag catgcccatc gacgacgccg tggaggccga cgtgtaccag      300

ctggacctgt gggccggcca gcagctgctg tggagcggca gcttccagcc cagcaagcac      360

gtgaagccca gaacccccgg caacctgacc gtgcacccca acatcagcca cacctggctg      420

ctgatgtgga ccaaccccta ccccaccgag aaccacctgc acagcgagct gacctacatg      480

gtgaacgtga gcaacgacaa cgaccccgag gacttcaagg tgtacaacgt gacctacatg      540

ggccccaccc tgagactggc cgccagcacc ctgaagagcg gcgccagcta cagcgccaga      600

gtgagagcct gggcccagac ctacaacagc acctggagcg actggagccc cagcaccacc      660

tggctgaact actacgagcc ctgggagcag cacctgcccc tgggcgtgag catcagctgc      720

ctggtgatcc tggccatctg cctgagctgc tacttcagca tcatcaagat caagaagggc      780

tggtgggacc agatccccaa ccccgcccac agccccctgg tggccatcgt gatccaggac      840

agccaggtga gcctgtgggg caagagaagc agaggccagg agcccgccaa gtgcccccac      900

tggaagacct gcctgaccaa gctgctgccc tgcctgctgg agcacggcct gggcagagag      960

gaggagagcc ccaagaccgc caagaacggc cccctgcagg gccccggcaa gcccgcctgg     1020

tgccccgtgg aggtgagcaa gaccatcctg tggcccgaga gcatcagcgt ggtgcagtgc     1080

gtggagctga gcgaggcccc cgtggacaac gaggaggagg aggaggtgga ggaggacaag     1140

agaagcctgt gccccagcct ggagggcagc ggcggcagct tccaggaggg cagagagggc     1200

atcgtggcca gactgaccga gagcctgttc ctggacctgc tgggcggcga gaacggcggc     1260

ttctgccccc agggcctgga ggagagctgc ctgccccccc ccagcggcag cgtgggcgcc     1320

cagatgccct gggcccagtt ccccagagcc ggccccagag ccgcccccga gggccccgag     1380

cagcccagaa gacccgagag cgccctgcag gccagcccca cccagagcgc cggcagcagc     1440

gccttccccg agcccccccc cgtggtgacc gacaaccccg cctacagaag cttcggcagc     1500

ttcctgggcc agagcagcga ccccggcgac ggcgacagcg accccgagct ggccgacaga     1560

cccggcgagg ccgaccccgg catccccagc gccccccagc cccccgagcc ccccgccgcc     1620

ctgcagcccg agcccgagag ctgggagcag atcctgagac agagcgtgct gcagcacaga     1680

gccgcccccg cccccggccc cggccccggc agcggctaca gagagttcac ctgcgccgtg     1740

aagcagggca gcgcccccga cgccggcggc cccggcttcg gccccagcgg cgaggccggc     1800

tacaaggcct tctgcagcct gctgcccggc ggcgccacct gccccggcac cagcggcggc     1860

gaggccggca gcggcgaggg cggctacaag cccttccaga gcctgacccc cggctgcccc     1920

ggcgccccca cccccgtgcc cgtgcccctg ttcaccttcg gcctggacac cgagcccccc     1980

ggcagccccc aggacagcct gggcgccggc agcagccccg agcacctggg cgtggagccc     2040

gccggcaagg aggaggacag cagaaagacc ctgctggccc ccgagcaggc caccgacccc     2100

ctgagagacg acctggccag cagcatcgtg tacagcgccc tgacctgcca cctgtgcggc     2160

cacctgaagc agtggcacga ccaggaggag agaggcaagg cccacatcgt gcccagcccc     2220

tgctgcggct gctgctgcgg cgacagaagc agcctgctgc tgagccccct gagagccccc     2280

aacgtgctgc ccggcggcgt gctgctggag gccagcctga gccccgccag cctggtgccc     2340

agcggcgtga gcaaggaggg caagagcagc cccttcagcc agcccgccag cagcagcgcc     2400

cagagcagca gccagacccc caagaagctg gccgtgctga gcaccgagcc cacctgcatg     2460

agcgccagc                                                             2469


<210>  2
<211>  823
<212>  PRT
<213>  Canis familiaris

<400>  2

Met Gly Arg Leu Cys Ser Gly Leu Thr Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Val Trp Val Ala Ser Ser Gly Ser Val Lys Val Leu His Glu Pro 
            20                  25                  30          


Ser Cys Phe Ser Asp Tyr Ile Ser Thr Ser Val Cys Gln Trp Lys Met 
        35                  40                  45              


Asp His Pro Thr Asn Cys Ser Ala Glu Leu Arg Leu Ser Tyr Gln Leu 
    50                  55                  60                  


Asp Phe Met Gly Ser Glu Asn His Thr Cys Val Pro Glu Asn Arg Glu 
65                  70                  75                  80  


Asp Ser Val Cys Val Cys Ser Met Pro Ile Asp Asp Ala Val Glu Ala 
                85                  90                  95      


Asp Val Tyr Gln Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Ser 
            100                 105                 110         


Gly Ser Phe Gln Pro Ser Lys His Val Lys Pro Arg Thr Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Ser His Thr Trp Leu Leu Met Trp Thr 
    130                 135                 140                 


Asn Pro Tyr Pro Thr Glu Asn His Leu His Ser Glu Leu Thr Tyr Met 
145                 150                 155                 160 


Val Asn Val Ser Asn Asp Asn Asp Pro Glu Asp Phe Lys Val Tyr Asn 
                165                 170                 175     


Val Thr Tyr Met Gly Pro Thr Leu Arg Leu Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ala Ser Tyr Ser Ala Arg Val Arg Ala Trp Ala Gln Thr Tyr 
        195                 200                 205             


Asn Ser Thr Trp Ser Asp Trp Ser Pro Ser Thr Thr Trp Leu Asn Tyr 
    210                 215                 220                 


Tyr Glu Pro Trp Glu Gln His Leu Pro Leu Gly Val Ser Ile Ser Cys 
225                 230                 235                 240 


Leu Val Ile Leu Ala Ile Cys Leu Ser Cys Tyr Phe Ser Ile Ile Lys 
                245                 250                 255     


Ile Lys Lys Gly Trp Trp Asp Gln Ile Pro Asn Pro Ala His Ser Pro 
            260                 265                 270         


Leu Val Ala Ile Val Ile Gln Asp Ser Gln Val Ser Leu Trp Gly Lys 
        275                 280                 285             


Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Thr Cys 
    290                 295                 300                 


Leu Thr Lys Leu Leu Pro Cys Leu Leu Glu His Gly Leu Gly Arg Glu 
305                 310                 315                 320 


Glu Glu Ser Pro Lys Thr Ala Lys Asn Gly Pro Leu Gln Gly Pro Gly 
                325                 330                 335     


Lys Pro Ala Trp Cys Pro Val Glu Val Ser Lys Thr Ile Leu Trp Pro 
            340                 345                 350         


Glu Ser Ile Ser Val Val Gln Cys Val Glu Leu Ser Glu Ala Pro Val 
        355                 360                 365             


Asp Asn Glu Glu Glu Glu Glu Val Glu Glu Asp Lys Arg Ser Leu Cys 
    370                 375                 380                 


Pro Ser Leu Glu Gly Ser Gly Gly Ser Phe Gln Glu Gly Arg Glu Gly 
385                 390                 395                 400 


Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly Gly 
                405                 410                 415     


Glu Asn Gly Gly Phe Cys Pro Gln Gly Leu Glu Glu Ser Cys Leu Pro 
            420                 425                 430         


Pro Pro Ser Gly Ser Val Gly Ala Gln Met Pro Trp Ala Gln Phe Pro 
        435                 440                 445             


Arg Ala Gly Pro Arg Ala Ala Pro Glu Gly Pro Glu Gln Pro Arg Arg 
    450                 455                 460                 


Pro Glu Ser Ala Leu Gln Ala Ser Pro Thr Gln Ser Ala Gly Ser Ser 
465                 470                 475                 480 


Ala Phe Pro Glu Pro Pro Pro Val Val Thr Asp Asn Pro Ala Tyr Arg 
                485                 490                 495     


Ser Phe Gly Ser Phe Leu Gly Gln Ser Ser Asp Pro Gly Asp Gly Asp 
            500                 505                 510         


Ser Asp Pro Glu Leu Ala Asp Arg Pro Gly Glu Ala Asp Pro Gly Ile 
        515                 520                 525             


Pro Ser Ala Pro Gln Pro Pro Glu Pro Pro Ala Ala Leu Gln Pro Glu 
    530                 535                 540                 


Pro Glu Ser Trp Glu Gln Ile Leu Arg Gln Ser Val Leu Gln His Arg 
545                 550                 555                 560 


Ala Ala Pro Ala Pro Gly Pro Gly Pro Gly Ser Gly Tyr Arg Glu Phe 
                565                 570                 575     


Thr Cys Ala Val Lys Gln Gly Ser Ala Pro Asp Ala Gly Gly Pro Gly 
            580                 585                 590         


Phe Gly Pro Ser Gly Glu Ala Gly Tyr Lys Ala Phe Cys Ser Leu Leu 
        595                 600                 605             


Pro Gly Gly Ala Thr Cys Pro Gly Thr Ser Gly Gly Glu Ala Gly Ser 
    610                 615                 620                 


Gly Glu Gly Gly Tyr Lys Pro Phe Gln Ser Leu Thr Pro Gly Cys Pro 
625                 630                 635                 640 


Gly Ala Pro Thr Pro Val Pro Val Pro Leu Phe Thr Phe Gly Leu Asp 
                645                 650                 655     


Thr Glu Pro Pro Gly Ser Pro Gln Asp Ser Leu Gly Ala Gly Ser Ser 
            660                 665                 670         


Pro Glu His Leu Gly Val Glu Pro Ala Gly Lys Glu Glu Asp Ser Arg 
        675                 680                 685             


Lys Thr Leu Leu Ala Pro Glu Gln Ala Thr Asp Pro Leu Arg Asp Asp 
    690                 695                 700                 


Leu Ala Ser Ser Ile Val Tyr Ser Ala Leu Thr Cys His Leu Cys Gly 
705                 710                 715                 720 


His Leu Lys Gln Trp His Asp Gln Glu Glu Arg Gly Lys Ala His Ile 
                725                 730                 735     


Val Pro Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser Ser Leu 
            740                 745                 750         


Leu Leu Ser Pro Leu Arg Ala Pro Asn Val Leu Pro Gly Gly Val Leu 
        755                 760                 765             


Leu Glu Ala Ser Leu Ser Pro Ala Ser Leu Val Pro Ser Gly Val Ser 
    770                 775                 780                 


Lys Glu Gly Lys Ser Ser Pro Phe Ser Gln Pro Ala Ser Ser Ser Ala 
785                 790                 795                 800 


Gln Ser Ser Ser Gln Thr Pro Lys Lys Leu Ala Val Leu Ser Thr Glu 
                805                 810                 815     


Pro Thr Cys Met Ser Ala Ser 
            820             


<210>  3
<211>  2394
<212>  DNA
<213>  Canis familiaris

<400>  3
gtgaaggtgc tgcacgagcc cagctgcttc agcgactaca tcagcaccag cgtgtgccag       60

tggaagatgg accaccccac caactgcagc gccgagctga gactgagcta ccagctggac      120

ttcatgggca gcgagaacca cacctgcgtg cccgagaaca gagaggacag cgtgtgcgtg      180

tgcagcatgc ccatcgacga cgccgtggag gccgacgtgt accagctgga cctgtgggcc      240

ggccagcagc tgctgtggag cggcagcttc cagcccagca agcacgtgaa gcccagaacc      300

cccggcaacc tgaccgtgca ccccaacatc agccacacct ggctgctgat gtggaccaac      360

ccctacccca ccgagaacca cctgcacagc gagctgacct acatggtgaa cgtgagcaac      420

gacaacgacc ccgaggactt caaggtgtac aacgtgacct acatgggccc caccctgaga      480

ctggccgcca gcaccctgaa gagcggcgcc agctacagcg ccagagtgag agcctgggcc      540

cagacctaca acagcacctg gagcgactgg agccccagca ccacctggct gaactactac      600

gagccctggg agcagcacct gcccctgggc gtgagcatca gctgcctggt gatcctggcc      660

atctgcctga gctgctactt cagcatcatc aagatcaaga agggctggtg ggaccagatc      720

cccaaccccg cccacagccc cctggtggcc atcgtgatcc aggacagcca ggtgagcctg      780

tggggcaaga gaagcagagg ccaggagccc gccaagtgcc cccactggaa gacctgcctg      840

accaagctgc tgccctgcct gctggagcac ggcctgggca gagaggagga gagccccaag      900

accgccaaga acggccccct gcagggcccc ggcaagcccg cctggtgccc cgtggaggtg      960

agcaagacca tcctgtggcc cgagagcatc agcgtggtgc agtgcgtgga gctgagcgag     1020

gcccccgtgg acaacgagga ggaggaggag gtggaggagg acaagagaag cctgtgcccc     1080

agcctggagg gcagcggcgg cagcttccag gagggcagag agggcatcgt ggccagactg     1140

accgagagcc tgttcctgga cctgctgggc ggcgagaacg gcggcttctg cccccagggc     1200

ctggaggaga gctgcctgcc cccccccagc ggcagcgtgg gcgcccagat gccctgggcc     1260

cagttcccca gagccggccc cagagccgcc cccgagggcc ccgagcagcc cagaagaccc     1320

gagagcgccc tgcaggccag ccccacccag agcgccggca gcagcgcctt ccccgagccc     1380

ccccccgtgg tgaccgacaa ccccgcctac agaagcttcg gcagcttcct gggccagagc     1440

agcgaccccg gcgacggcga cagcgacccc gagctggccg acagacccgg cgaggccgac     1500

cccggcatcc ccagcgcccc ccagcccccc gagccccccg ccgccctgca gcccgagccc     1560

gagagctggg agcagatcct gagacagagc gtgctgcagc acagagccgc ccccgccccc     1620

ggccccggcc ccggcagcgg ctacagagag ttcacctgcg ccgtgaagca gggcagcgcc     1680

cccgacgccg gcggccccgg cttcggcccc agcggcgagg ccggctacaa ggccttctgc     1740

agcctgctgc ccggcggcgc cacctgcccc ggcaccagcg gcggcgaggc cggcagcggc     1800

gagggcggct acaagccctt ccagagcctg acccccggct gccccggcgc ccccaccccc     1860

gtgcccgtgc ccctgttcac cttcggcctg gacaccgagc cccccggcag cccccaggac     1920

agcctgggcg ccggcagcag ccccgagcac ctgggcgtgg agcccgccgg caaggaggag     1980

gacagcagaa agaccctgct ggcccccgag caggccaccg accccctgag agacgacctg     2040

gccagcagca tcgtgtacag cgccctgacc tgccacctgt gcggccacct gaagcagtgg     2100

cacgaccagg aggagagagg caaggcccac atcgtgccca gcccctgctg cggctgctgc     2160

tgcggcgaca gaagcagcct gctgctgagc cccctgagag cccccaacgt gctgcccggc     2220

ggcgtgctgc tggaggccag cctgagcccc gccagcctgg tgcccagcgg cgtgagcaag     2280

gagggcaaga gcagcccctt cagccagccc gccagcagca gcgcccagag cagcagccag     2340

acccccaaga agctggccgt gctgagcacc gagcccacct gcatgagcgc cagc           2394


<210>  4
<211>  798
<212>  PRT
<213>  Canis familiaris

<400>  4

Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile Ser Thr 
1               5                   10                  15      


Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser Ala Glu 
            20                  25                  30          


Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn His Thr 
        35                  40                  45              


Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser Met Pro 
    50                  55                  60                  


Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu Trp Ala 
65                  70                  75                  80  


Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys His Val 
                85                  90                  95      


Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile Ser His 
            100                 105                 110         


Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn His Leu 
        115                 120                 125             


His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn Asp Pro 
    130                 135                 140                 


Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr Leu Arg 
145                 150                 155                 160 


Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala Arg Val 
                165                 170                 175     


Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp Ser Pro 
            180                 185                 190         


Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Trp Glu Gln His Leu Pro 
        195                 200                 205             


Leu Gly Val Ser Ile Ser Cys Leu Val Ile Leu Ala Ile Cys Leu Ser 
    210                 215                 220                 


Cys Tyr Phe Ser Ile Ile Lys Ile Lys Lys Gly Trp Trp Asp Gln Ile 
225                 230                 235                 240 


Pro Asn Pro Ala His Ser Pro Leu Val Ala Ile Val Ile Gln Asp Ser 
                245                 250                 255     


Gln Val Ser Leu Trp Gly Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys 
            260                 265                 270         


Cys Pro His Trp Lys Thr Cys Leu Thr Lys Leu Leu Pro Cys Leu Leu 
        275                 280                 285             


Glu His Gly Leu Gly Arg Glu Glu Glu Ser Pro Lys Thr Ala Lys Asn 
    290                 295                 300                 


Gly Pro Leu Gln Gly Pro Gly Lys Pro Ala Trp Cys Pro Val Glu Val 
305                 310                 315                 320 


Ser Lys Thr Ile Leu Trp Pro Glu Ser Ile Ser Val Val Gln Cys Val 
                325                 330                 335     


Glu Leu Ser Glu Ala Pro Val Asp Asn Glu Glu Glu Glu Glu Val Glu 
            340                 345                 350         


Glu Asp Lys Arg Ser Leu Cys Pro Ser Leu Glu Gly Ser Gly Gly Ser 
        355                 360                 365             


Phe Gln Glu Gly Arg Glu Gly Ile Val Ala Arg Leu Thr Glu Ser Leu 
    370                 375                 380                 


Phe Leu Asp Leu Leu Gly Gly Glu Asn Gly Gly Phe Cys Pro Gln Gly 
385                 390                 395                 400 


Leu Glu Glu Ser Cys Leu Pro Pro Pro Ser Gly Ser Val Gly Ala Gln 
                405                 410                 415     


Met Pro Trp Ala Gln Phe Pro Arg Ala Gly Pro Arg Ala Ala Pro Glu 
            420                 425                 430         


Gly Pro Glu Gln Pro Arg Arg Pro Glu Ser Ala Leu Gln Ala Ser Pro 
        435                 440                 445             


Thr Gln Ser Ala Gly Ser Ser Ala Phe Pro Glu Pro Pro Pro Val Val 
    450                 455                 460                 


Thr Asp Asn Pro Ala Tyr Arg Ser Phe Gly Ser Phe Leu Gly Gln Ser 
465                 470                 475                 480 


Ser Asp Pro Gly Asp Gly Asp Ser Asp Pro Glu Leu Ala Asp Arg Pro 
                485                 490                 495     


Gly Glu Ala Asp Pro Gly Ile Pro Ser Ala Pro Gln Pro Pro Glu Pro 
            500                 505                 510         


Pro Ala Ala Leu Gln Pro Glu Pro Glu Ser Trp Glu Gln Ile Leu Arg 
        515                 520                 525             


Gln Ser Val Leu Gln His Arg Ala Ala Pro Ala Pro Gly Pro Gly Pro 
    530                 535                 540                 


Gly Ser Gly Tyr Arg Glu Phe Thr Cys Ala Val Lys Gln Gly Ser Ala 
545                 550                 555                 560 


Pro Asp Ala Gly Gly Pro Gly Phe Gly Pro Ser Gly Glu Ala Gly Tyr 
                565                 570                 575     


Lys Ala Phe Cys Ser Leu Leu Pro Gly Gly Ala Thr Cys Pro Gly Thr 
            580                 585                 590         


Ser Gly Gly Glu Ala Gly Ser Gly Glu Gly Gly Tyr Lys Pro Phe Gln 
        595                 600                 605             


Ser Leu Thr Pro Gly Cys Pro Gly Ala Pro Thr Pro Val Pro Val Pro 
    610                 615                 620                 


Leu Phe Thr Phe Gly Leu Asp Thr Glu Pro Pro Gly Ser Pro Gln Asp 
625                 630                 635                 640 


Ser Leu Gly Ala Gly Ser Ser Pro Glu His Leu Gly Val Glu Pro Ala 
                645                 650                 655     


Gly Lys Glu Glu Asp Ser Arg Lys Thr Leu Leu Ala Pro Glu Gln Ala 
            660                 665                 670         


Thr Asp Pro Leu Arg Asp Asp Leu Ala Ser Ser Ile Val Tyr Ser Ala 
        675                 680                 685             


Leu Thr Cys His Leu Cys Gly His Leu Lys Gln Trp His Asp Gln Glu 
    690                 695                 700                 


Glu Arg Gly Lys Ala His Ile Val Pro Ser Pro Cys Cys Gly Cys Cys 
705                 710                 715                 720 


Cys Gly Asp Arg Ser Ser Leu Leu Leu Ser Pro Leu Arg Ala Pro Asn 
                725                 730                 735     


Val Leu Pro Gly Gly Val Leu Leu Glu Ala Ser Leu Ser Pro Ala Ser 
            740                 745                 750         


Leu Val Pro Ser Gly Val Ser Lys Glu Gly Lys Ser Ser Pro Phe Ser 
        755                 760                 765             


Gln Pro Ala Ser Ser Ser Ala Gln Ser Ser Ser Gln Thr Pro Lys Lys 
    770                 775                 780                 


Leu Ala Val Leu Ser Thr Glu Pro Thr Cys Met Ser Ala Ser 
785                 790                 795             


<210>  5
<211>  208
<212>  PRT
<213>  Canis familiaris

<400>  5

Val Lys Val Leu His Glu Pro Ser Cys Phe Ser Asp Tyr Ile Ser Thr 
1               5                   10                  15      


Ser Val Cys Gln Trp Lys Met Asp His Pro Thr Asn Cys Ser Ala Glu 
            20                  25                  30          


Leu Arg Leu Ser Tyr Gln Leu Asp Phe Met Gly Ser Glu Asn His Thr 
        35                  40                  45              


Cys Val Pro Glu Asn Arg Glu Asp Ser Val Cys Val Cys Ser Met Pro 
    50                  55                  60                  


Ile Asp Asp Ala Val Glu Ala Asp Val Tyr Gln Leu Asp Leu Trp Ala 
65                  70                  75                  80  


Gly Gln Gln Leu Leu Trp Ser Gly Ser Phe Gln Pro Ser Lys His Val 
                85                  90                  95      


Lys Pro Arg Thr Pro Gly Asn Leu Thr Val His Pro Asn Ile Ser His 
            100                 105                 110         


Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu Asn His Leu 
        115                 120                 125             


His Ser Glu Leu Thr Tyr Met Val Asn Val Ser Asn Asp Asn Asp Pro 
    130                 135                 140                 


Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met Gly Pro Thr Leu Arg 
145                 150                 155                 160 


Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser Tyr Ser Ala Arg Val 
                165                 170                 175     


Arg Ala Trp Ala Gln Thr Tyr Asn Ser Thr Trp Ser Asp Trp Ser Pro 
            180                 185                 190         


Ser Thr Thr Trp Leu Asn Tyr Tyr Glu Pro Trp Glu Gln His Leu Pro 
        195                 200                 205             


<210>  6
<211>  17
<212>  PRT
<213>  Canis familiaris

<400>  6

Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Pro 
    


<210>  7
<211>  22
<212>  PRT
<213>  Canis familiaris

<400>  7

Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Met 
            20          


<210>  8
<211>  20
<212>  PRT
<213>  Canis familiaris

<400>  8

Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro 
1               5                   10                  15      


Gly Cys Gly Leu 
            20  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine

<400>  9

Pro Lys Glu Ser Thr Cys Lys Cys Ile Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Ser 
    


<210>  10
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine

<400>  10

Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
1               5                   10                  15      


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            20                  25                  30          


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        35                  40                  45              


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    50                  55                  60                  


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
65                  70                  75                  80  


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                85                  90                  95      


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            100                 105                 110         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        115                 120                 125             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    130                 135                 140                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
145                 150                 155                 160 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                165                 170                 175     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            180                 185                 190         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        195                 200                 205             


Leu Ser His Ser Pro Gly 
    210                 


<210>  11
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  11
agatactgga tgcac                                                        15


<210>  12
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  12

Arg Tyr Trp Met His 
1               5   


<210>  13
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  13
atgattcacc ccgacagcgg caacatcaac tacaacgagc ggttcaagac c                51


<210>  14
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ile His Pro Asp Ser Gly Asn Ile Asn Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  15
cagctgcgga acgccatgga ttat                                              24


<210>  16
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Leu Arg Asn Ala Met Asp Tyr 
1               5               


<210>  17
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  17
agagccagcg agagcgtgga cagctacggc aacagcttcc tgaac                       45


<210>  18
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  18

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Leu Asn 
1               5                   10                  15  


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  19
agagccagca acctggcctc t                                                 21


<210>  20
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  20

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  21
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  21
cagcagaact acgagaaccc cagaacc                                           27


<210>  22
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  22

Gln Gln Asn Tyr Glu Asn Pro Arg Thr 
1               5                   


<210>  23
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  23
agctacggca tgagc                                                        15


<210>  24
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  24

Ser Tyr Gly Met Ser 
1               5   


<210>  25
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  25
acaatcagca gaggcggcga ctacacctac tatcccgaca gcgtgaaggg c                51


<210>  26
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  26

Thr Ile Ser Arg Gly Gly Asp Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  27
ggcaccctga acaaccgggg ctttgcttct                                        30


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified murine

<400>  28

Gly Thr Leu Asn Asn Arg Gly Phe Ala Ser 
1               5                   10  


<210>  29
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  29
aaggccagcc agaacgtggg caccaatgtg gcc                                    33


<210>  30
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  30

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  31
agcgccagct accggtactc t                                                 21


<210>  32
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  32

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  33
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  33
cagcagtaca acagctaccc ctacacc                                           27


<210>  34
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  35
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  35

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Leu Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Glu Phe Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  36
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Gly Gly Asp Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Thr Leu Asn Asn Arg Gly Phe Ala Cys Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly 
    450             


<210>  37
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Asp Lys Arg Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Gly Gly Asp Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Leu Asn Asn Arg Gly Phe Ala Cys Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly 
    450             


<210>  38
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Asp Lys Arg Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Arg Gly Gly Asp Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Leu Asn Asn Arg Gly Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly 
    450             


<210>  39
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  39

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Tyr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Glu Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Glu Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Asn Tyr 
                85                  90                  95      


Glu Asn Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln 
        115                 120                 125             


Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp 
145                 150                 155                 160 


Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His 
            180                 185                 190         


Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu 
        195                 200                 205             


Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220     


<210>  40
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  40

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Met Ile His Pro Asp Ser Gly Asn Ile Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Thr Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Arg Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  41
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  41

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Arg Tyr 
            20                  25                  30          


Trp Met His Trp Met Lys Gln Ala Pro Gly Ala Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asp Ser Gly Asn Ile Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Arg Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  42
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  42

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Arg Tyr 
            20                  25                  30          


Trp Met His Trp Met Lys Gln Ala Pro Gly Ala Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asp Ser Gly Asn Ile Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Arg Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys 
    130                 135                 140                 


Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg 
            180                 185                 190         


Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys 
        195                 200                 205             


Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro 
    210                 215                 220                 


Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln 
        275                 280                 285             


Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys 
305                 310                 315                 320 


Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp 
    370                 375                 380                 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro 
385                 390                 395                 400 


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  43
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  43

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val 
            20                  25                  30          


Ala Trp Tyr Gln Gln Leu Pro Gly Thr Ser Pro Arg Thr Leu Ile Tyr 
        35                  40                  45              


Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Gly Leu Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly Gln Pro Lys Ala Ser 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gly Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Ser Gly Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Thr Gln Gly Val Glu 
145                 150                 155                 160 


Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Asp Lys Trp Lys Ser His Ser Ser Phe Ser 
            180                 185                 190         


Cys Leu Val Thr His Glu Gly Ser Thr Val Glu Lys Lys Val Ala Pro 
        195                 200                 205             


Ala Glu Cys Ser 
    210         


<210>  44
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized murine

<400>  44

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly 
            20                  25                  30          


Asn Ser Phe Leu Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Ser 
        35                  40                  45              


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Glu Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Ser Ser Ala Thr Leu Thr Ile Thr Gly 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Asn Tyr Glu 
                85                  90                  95      


Asn Pro Arg Thr Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gly Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Ser Gly Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Thr 
145                 150                 155                 160 


Gln Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Asp Lys Trp Lys Ser His 
            180                 185                 190         


Ser Ser Phe Ser Cys Leu Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Lys Val Ala Pro Ala Glu Cys Ser 
    210                 215     


<210>  45
<211>  215
<212>  PRT
<213>  Canis familiaris

<400>  45

Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
1               5                   10                  15      


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            20                  25                  30          


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        35                  40                  45              


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    50                  55                  60                  


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
65                  70                  75                  80  


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                85                  90                  95      


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            100                 105                 110         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        115                 120                 125             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    130                 135                 140                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
145                 150                 155                 160 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                165                 170                 175     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            180                 185                 190         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        195                 200                 205             


Leu Ser His Ser Pro Gly Lys 
    210                 215 


<210>  46
<211>  21
<212>  PRT
<213>  Canis familiaris

<400>  46

Ile Ser His Thr Trp Leu Leu Met Trp Thr Asn Pro Tyr Pro Thr Glu 
1               5                   10                  15      


Asn His Leu His Ser 
            20      


<210>  47
<211>  41
<212>  PRT
<213>  Canis familiaris

<400>  47

Asn Asp Asn Asp Pro Glu Asp Phe Lys Val Tyr Asn Val Thr Tyr Met 
1               5                   10                  15      


Gly Pro Thr Leu Arg Leu Ala Ala Ser Thr Leu Lys Ser Gly Ala Ser 
            20                  25                  30          


Tyr Ser Ala Arg Val Arg Ala Trp Ala 
        35                  40      


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  computer generated based on the amino acid sequence of the CDR

<400>  48
ggcaccctga acaaccgcgg ctttgcgtgc                                        30


<210>  49
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  49

Gly Thr Leu Asn Asn Arg Gly Phe Ala Cys 
1               5                   10  


