                         SEQUENCE LISTING

<110>  Kymab Limited
 
<120>  EXPRESSION OF SEQUENCE-ENGINEERED LAMBDA ANTIBODY LIGHT CHAINS

<130>  K00034-2 WO

<150>  PCT/EP2019/086808
<151>  2019-12-20

<150>  GB1919077.6
<151>  2019-12-20

<150>  PCT/EP2020/063515
<151>  2020-05-14

<160>  124   

<170>  PatentIn version 3.5

<210>  1
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  1

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly 
        


<210>  2
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  2

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly 
            


<210>  3
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  3

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asp Met Gly Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Trp 
65                  70                  75                  80  


Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Ala Trp Asp Thr Ser Pro 
                85                  90                  95      


Arg Ala 
        


<210>  4
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly 
        


<210>  5
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  5

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly 
        


<210>  6
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  6

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Val Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Gln Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Lys Ala Trp Asp Asn Ser 
                85                  90                  95      


Leu Asn Ala 
            


<210>  7
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  7

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala 
        


<210>  8
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  8

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Trp Ala Thr Arg Gln 
1               5                   10                  15      


Arg Leu Thr Val Ser Cys Thr Gly Ser Ser Ser Asn Thr Gly Thr Gly 
            20                  25                  30          


Tyr Asn Val Asn Cys Trp Gln Leu Pro Arg Thr Asp Pro Lys Leu Leu 
        35                  40                  45              


Arg His Gly Asp Lys Asn Trp Ala Ser Trp Val Ser Asp Gln Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Leu Ala Ser Leu Gly Thr Thr Gly Leu Trp 
65                  70                  75                  80  


Ala Glu Asp Lys Thr Asp Tyr His Cys Gln Ser Arg Asp Ile Cys Val 
                85                  90                  95      


Leu 
    


<210>  9
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  9

Gln Ser Ala Leu Ile Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Thr Val Pro Lys Pro 
        35                  40                  45              


Met Ile Tyr Asn Val Asn Thr Gln Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Cys Cys Ser Tyr Thr Ser Ser Ala 
                85                  90                  95      


Thr 
    


<210>  10
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  10

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe 
            


<210>  11
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  11

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Tyr Thr Phe 
            


<210>  12
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  12

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu 
            


<210>  13
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  13

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Arg Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Leu Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Phe 
            


<210>  14
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  14

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Leu 
            


<210>  15
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  15

Gln Ser Ala Leu Thr Gln Pro Pro Phe Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Tyr 
            20                  25                  30          


Asp His Val Phe Trp Tyr Gln Lys Arg Leu Ser Thr Thr Ser Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asn Val Asn Thr Arg Pro Ser Gly Ile Ser Asp Leu Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Met Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Lys Ser Glu Val Glu Ala Asn Tyr His Cys Ser Leu Tyr Ser Ser Ser 
                85                  90                  95      


Tyr Thr Phe 
            


<210>  16
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  16

Gln Ser Val Leu Thr Gln Pro Arg Ser Val Ser Arg Ser Pro Gly Gln 
1               5                   10                  15      


Val Thr Ile Phe Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr Asp 
            20                  25                  30          


Leu Val Ser Trp Cys Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Asp Val Ala Asn Trp Pro Ser Gly Ala Pro Gly Cys Phe Ser Gly 
    50                  55                  60                  


Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Tyr Asn 
                85                  90                  95      


Phe 
    


<210>  17
<211>  97
<212>  PRT
<213>  Homo Sapiens

<400>  17

Gln Ser Val Leu Thr Gln Pro Arg Ser Val Ser Arg Ser Pro Gly Gln 
1               5                   10                  15      


Val Thr Ile Phe Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr Asp 
            20                  25                  30          


Leu Val Ser Trp Cys Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Asp Val Gly Asn Trp Pro Ser Gly Ala Pro Gly Cys Phe Ser Gly 
    50                  55                  60                  


Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Tyr Asn 
                85                  90                  95      


Phe 
    


<210>  18
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  18

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala 
                85                  90                  95  


<210>  19
<211>  95
<212>  PRT
<213>  Homo Sapiens

<400>  19

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr Ala 
                85                  90                  95  


<210>  20
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  20

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Met Ala Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Thr Asp Ser Ser Gly Asn His 
                85                  90                  95      


<210>  21
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  21

Ser Tyr Glu Leu Thr Gln Pro His Ser Val Ser Val Ala Thr Ala Gln 
1               5                   10                  15      


Met Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ala Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Asp Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ser Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Pro Gly Asn Thr Thr Thr Leu Thr Ile Ser Arg Ile Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


<210>  22
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  22

Ser Tyr Glu Leu Thr Gln Pro Pro Ala Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Val Leu Arg Asp Asn Tyr Ala 
            20                  25                  30          


Asp Trp Tyr Pro Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Gly Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Thr Ala Leu Thr Ile Ser Arg Val Leu Thr Lys 
65                  70                  75                  80  


Gly Gly Ala Asp Tyr Tyr Cys Phe Ser Gly Asp Asn Asn 
                85                  90              


<210>  23
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  23

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Met Ala Arg Ile Thr Cys Ser Gly Glu Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Phe Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Ile Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Ala Asp Ser Ser Gly Thr Tyr 
                85                  90                  95      


<210>  24
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  24

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


<210>  25
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  25

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


<210>  26
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  26

Ser Tyr Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Gly Glu Asn Tyr Ala 
            20                  25                  30          


Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Glu Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Glu Arg Tyr Pro Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Thr Thr Leu Thr Ile Ser Arg Val Leu Thr Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Leu Ser Gly Asp Glu Asp Asn 
                85                  90                  


<210>  27
<211>  96
<212>  PRT
<213>  Homo Sapiens

<400>  27

Ser Tyr Glu Leu Met Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr 
                85                  90                  95      


<210>  28
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  28

Ser Tyr Glu Leu Thr Gln Pro Ser Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 
            20                  25                  30          


Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp Asn Asn 
                85                  90                  


<210>  29
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  29

Ser Ser Glu Leu Ser Gln Glu Pro Ala Val Ser Val Ala Leu Gly Thr 
1               5                   10                  15      


Ala Arg Ile Thr Cys Gln Gly Asp Ser Ile Glu Asp Ser Val Val Asn 
            20                  25                  30          


Trp Tyr Lys Gln Lys Pro Ser Gln Ala Pro Gly Leu Val Ile Leu Asn 
        35                  40                  45              


Ser Val Gln Ser Ser Gly Ile Pro Lys Lys Phe Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Asn Met Ala Thr Leu Thr Ile Thr Gly Ile Gln Val Glu Asp Lys 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Ser Ser Arg Thr His 
                85                  90                  


<210>  30
<211>  94
<212>  PRT
<213>  Homo Sapiens

<400>  30

Ser Ser Gly Pro Thr Gln Val Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Met Ala Arg Ile Thr Cys Gln Gly Asp Ser Met Glu Gly Ser Tyr Glu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Ser Ser Asp Arg Pro Ser Arg Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asn Thr Thr Thr Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Tyr Gln Leu Ile Asp Asn His Ala 
                85                  90                  


<210>  31
<211>  103
<212>  PRT
<213>  Homo Sapiens

<400>  31

Leu Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Leu Leu Gly Ala 
1               5                   10                  15      


Ser Ile Lys Leu Thr Cys Thr Leu Ser Ser Glu His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln Arg Pro Gly Arg Ser Pro Gln Tyr Ile Met 
        35                  40                  45              


Lys Val Lys Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Met Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Phe Ser 
65                  70                  75                  80  


Asn Leu Gln Ser Asp Asp Glu Ala Glu Tyr His Cys Gly Glu Ser His 
                85                  90                  95      


Thr Ile Asp Gly Gln Val Gly 
            100             


<210>  32
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  32

Gln Pro Val Leu Thr Gln Ser Ser Ser Ala Ser Ala Ser Leu Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ile 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Gly Lys Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Glu Gly Ser Gly Ser Tyr Asn Lys Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Asn Leu Gln Leu Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp 
                85                  90                  95      


Ser Asn Thr 
            


<210>  33
<211>  99
<212>  PRT
<213>  Homo Sapiens

<400>  33

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly 
                85                  90                  95      


Thr Gly Ile 
            


<210>  34
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  34

Gln Pro Val Leu Thr Gln Pro Pro Ser Ser Ser Ala Ser Pro Gly Glu 
1               5                   10                  15      


Ser Ala Arg Leu Thr Cys Thr Leu Pro Ser Asp Ile Asn Val Gly Ser 
            20                  25                  30          


Tyr Asn Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Arg Tyr 
        35                  40                  45              


Leu Leu Tyr Tyr Tyr Ser Asp Ser Asp Lys Gly Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Thr Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp Pro Ser Asn Ala Ser 
            100                 


<210>  35
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  35

Gln Pro Val Leu Thr Gln Pro Thr Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Arg Phe Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Thr 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Leu Pro Arg Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Thr Asn Ala Gly Leu 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Trp Tyr Ser Ser Thr Ser 
            100                 


<210>  36
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  36

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Thr 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ser 
            100                 


<210>  37
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  37

Gln Pro Val Leu Thr Gln Pro Thr Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Arg Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Leu Gly Ser 
            20                  25                  30          


Tyr Arg Ile Phe Trp Tyr Gln Gln Lys Pro Glu Ser Pro Pro Arg Tyr 
        35                  40                  45              


Leu Leu Ser Tyr Tyr Ser Asp Ser Ser Lys His Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ser Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Val Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ser 
            100                 


<210>  38
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  38

Gln Pro Val Leu Thr Gln Pro Ser Ser His Ser Ala Ser Ser Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Thr Cys Met Leu Ser Ser Gly Phe Ser Val Gly Asp 
            20                  25                  30          


Phe Trp Ile Arg Trp Tyr Gln Gln Lys Pro Gly Asn Pro Pro Arg Tyr 
        35                  40                  45              


Leu Leu Tyr Tyr His Ser Asp Ser Asn Lys Gly Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Asn Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Arg Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Gly Thr Trp His Ser Asn Ser Lys Thr 
            100                 105 


<210>  39
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  39

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn 
        


<210>  40
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  40

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala 
        35                  40                  45              


Leu Ile Tyr Ser Thr Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly 
                85                  90                  95      


Ala Gln 
        


<210>  41
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  41

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


His Tyr Pro Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Asp Thr Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Ser Tyr Ser Gly 
                85                  90                  95      


Ala Arg 
        


<210>  42
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  42

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile 
        


<210>  43
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  43

Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser Asn Tyr Lys 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg Phe Val Met 
        35                  40                  45              


Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr Leu Thr Ile 
65                  70                  75                  80  


Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys Gly Ala Asp 
                85                  90                  95      


His Gly Ser Gly Ser Asn Phe Val 
            100                 


<210>  44
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  44

Gln Ala Gly Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Thr Gly Asn Ser Asn Asn Val Gly Asn Gln 
            20                  25                  30          


Gly Ala Ala Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu Leu 
        35                  40                  45              


Ser Tyr Arg Asn Asn Asn Arg Pro Ser Gly Ile Ser Glu Arg Leu Ser 
    50                  55                  60                  


Ala Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala 
        


<210>  45
<211>  104
<212>  PRT
<213>  Homo Sapiens

<400>  45

Arg Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Thr Ala Arg Leu Pro Cys Thr Leu Ser Ser Asp Leu Ser Val Gly Gly 
            20                  25                  30          


Lys Asn Met Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu 
        35                  40                  45              


Phe Leu Tyr His Tyr Ser Asp Ser Asp Lys Gln Leu Gly Pro Gly Val 
    50                  55                  60                  


Pro Ser Arg Val Ser Gly Ser Lys Glu Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Gln Val Tyr Glu Ser Ser Ala Asn 
            100                 


<210>  46
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  46

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro 
1               5                   10                  


<210>  47
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  47

Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
1               5                   10      


<210>  48
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  48

Ser Ser Asn Ile Gly Asn Asn Ala 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  49

Val Asn Trp Tyr Gln Gln Leu Pro 
1               5               


<210>  50
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  50

Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   


<210>  51
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  51

Leu Leu Pro Ser Gly Val Ser Asp 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  52

Arg Phe Ser Gly Ser Lys Ser Gly 
1               5               


<210>  53
<211>  12
<212>  PRT
<213>  Homo Sapiens

<400>  53

Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser 
1               5                   10          


<210>  54
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  54

Glu Asp Glu Ala Asp Tyr Tyr Cys 
1               5               


<210>  55
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  55

Ala Ala Trp Asp Asp Ser Leu Asn Gly 
1               5                   


<210>  56
<211>  290
<212>  DNA
<213>  Homo Sapiens

<400>  56
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatcc                 290


<210>  57
<211>  290
<212>  DNA
<213>  Homo Sapiens

<400>  57
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gacagtagta gtgatcatcc                 290


<210>  58
<211>  290
<212>  DNA
<213>  Homo Sapiens

<400>  58
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatcc                 290


<210>  59
<211>  290
<212>  DNA
<213>  Homo Sapiens

<400>  59
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatcc                 290


<210>  60
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  60

Met Ala Trp Thr Ala Leu Leu Leu Gly Leu Leu Ser His Cys Thr Gly 
1               5                   10                  15      


Ser Val Thr 
            


<210>  61
<211>  57
<212>  DNA
<213>  Homo Sapiens

<400>  61
atggcctgga ccgctctcct cctcggcctc ctctctcact gcacaggctc tgtgacc          57


<210>  62
<211>  20
<212>  PRT
<213>  Mus Musculus

<400>  62

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  63
<211>  60
<212>  DNA
<213>  Mus Musculus

<400>  63
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgt       60


<210>  64
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding mouse kappa light chain signal 
       peptide, codon-optimised for CHO

<400>  64
atgtctgtgc ctacacaggt tctgggactg ctgctgctgt ggctgaccga cgccagatgt       60


<210>  65
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding 0325L VL domain with signal peptide

<400>  65
atgtctgtgc ctacacaggt tctgggactg ctgctgctgt ggctgaccga cgccagatgt       60

tacgtgctga cccagcctcc ttccgtgtct gttgctcctg gcgagacagc cagaatcacc      120

tgtggcggcg ataacatcgg ccggaagtcc gtgtactggt atcagcagaa gtccggccag      180

gctcctgtgc tggtcatcta ctacgactcc gaccggcctt ctggcatccc tgagagattc      240

tccggctcca actccggcaa taccgccaca ctgaccatct ccagagtgga agctggcgac      300

gaggccgact actactgcca agtgtgggac ggctcctctg accactgggt tttcggcgga      360

ggcaccaagc tgacagtgct g                                                381


<210>  66
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0325L with mouse kappa signal peptide

<400>  66

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala 
            20                  25                  30          


Pro Gly Glu Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Arg 
        35                  40                  45              


Lys Ser Val Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val 
                85                  90                  95      


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser 
            100                 105                 110         


Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125         


<210>  67
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lambda light chain comprising 0325L VL domain with mouse kappa 
       signal peptide

<400>  67

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala 
            20                  25                  30          


Pro Gly Glu Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Arg 
        35                  40                  45              


Lys Ser Val Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val 
                85                  90                  95      


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser 
            100                 105                 110         


Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
        115                 120                 125             


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
145                 150                 155                 160 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
                165                 170                 175     


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
            180                 185                 190         


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
        195                 200                 205             


His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
    210                 215                 220                 


Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230             


<210>  68
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  0128L VL domain with mouse kappa signal peptide

<400>  68

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Glu Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly 
        35                  40                  45              


Arg Lys Ser Val Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Ile Tyr Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly 
            100                 105                 110         


Ser Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  69
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V12 signal peptide derived from Sandfly Yellow related protein

<400>  69

Met Arg Phe Phe Phe Val Phe Leu Ala Ile Val Leu Phe Gln Gly Ile 
1               5                   10                  15      


His Gly 
        


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V14 signal peptide derived from Silkworm Fibroin LC

<400>  70

Met Lys Pro Ile Phe Leu Val Leu Leu Trp Thr Ser Ala Tyr Ala 
1               5                   10                  15  


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V16 signal peptide derived from Snake PLA2

<400>  71

Met Arg Thr Leu Trp Ile Met Ala Val Leu Leu Leu Gly Val Glu Gly 
1               5                   10                  15      


<210>  72
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V17 signal peptide derived from Cypridina Noctiluca luciferase

<400>  72

Met Lys Thr Leu Ile Leu Ala Val Ala Leu Val Tyr Cys Ala Thr Val 
1               5                   10                  15      


His Cys 
        


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V19 signal peptide derived from Pinemoth Fibroin LC

<400>  73

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  74
<211>  19
<212>  PRT
<213>  Mus Musculus

<400>  74

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  75
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  75

Ala Trp Thr Pro Leu Leu Leu Pro Leu Leu Thr Leu Cys Thr Ser 
1               5                   10                  15  


<210>  76
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  76

Met Ala Gly Phe Pro Leu Leu Leu Thr Leu Leu Thr His Cys Ala Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  77
<211>  22
<212>  PRT
<213>  Homo Sapiens

<400>  77

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys 
            20          


<210>  78
<211>  366
<212>  DNA
<213>  Homo Sapiens

<400>  78
gaggtgcagc tggtggagtc tgggggaggc tttgtccagc ctggggggtc cctgagactc       60

tcctgtgcag tctctggatt cagatttaat agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtag aaaattctat      180

gtggcctctg tgaagggccg attcaccatg tccagagaca acgccaagaa atcagtgtat      240

gtacaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagagggg      300

tatagtagta tcaagtatta tggtatggac gtctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  79
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Arg Phe Asn Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Arg Lys Phe Tyr Val Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Lys Ser Val Tyr 
65                  70                  75                  80  


Val Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Ser Ile Lys Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  80
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding N1280H-IgG4-P K439E heavy chain; N1280 
       coding sequence underlined

<400>  80
gaagtgcagc tggttgaatc tggcggcgga tttgttcagc ctggcggctc tctgagactg       60

tcctgtgctg tgtccggctt ccggttcaac tcctactgga tgtcctgggt ccgacaggct      120

cctggcaaag gactggaatg ggtcgccaac atcaaccagg acggctcccg gaagttctac      180

gtggcctctg tgaagggcag attcaccatg tctcgggaca acgccaagaa atccgtgtac      240

gtgcagatga actccctgag agccgaggac accgccgtgt actactgtgc tagagagggc      300

tactcctcca tcaagtacta cggcatggac gtgtggggcc agggcacaac cgtgacagtc      360

tcttccgctt ccaccaaggg acccagcgtt ttccctctgg ctccttgctc cagatccacc      420

tccgagtcta cagctgctct gggctgcctg gtcaaggact actttcctga gcctgtgacc      480

gtgtcctgga actctggcgc tctgacatct ggcgtgcaca cctttccagc tgtgctgcag      540

tcctccggcc tgtactctct gtcctctgtc gtgaccgtgc cttccagctc tctgggaacc      600

cagacctaca cctgtaatgt ggaccacaag ccttccaaca ccaaggtgga caagcgcgtg      660

gaatctaagt acggccctcc ttgtcctcca tgtcctgctc cagagtttct cggcggaccc      720

tccgtgtttc tgttccctcc aaagcctaag gacaccctga tgatctctcg gacccctgaa      780

gtgacctgcg tggtggtgga tgtgtcccaa gaggatcccg aggtgcagtt caattggtac      840

gtggacggcg tggaagtgca caatgccaag accaagccta gagaggaaca gtacaactcc      900

acctacagag tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaagag      960

tacaagtgca aggtgtccaa caagggcctg cctagctcca tcgaaaagac catctccaag     1020

gccaagggcc agcctcgaga accccaggtt tacaccctgc ctccaagcca agaggaaatg     1080

accaagaacc aggtgtccct gacctgtctc gtgaagggct tctacccctc cgatatcgcc     1140

gtggaatggg agtctaatgg ccagccagag aacaactaca agaccacacc tccagtgctg     1200

gactccgacg gctcattctt tctgtactcc aagctgacag tggacaagtc ccggtggcaa     1260

gagggcaacg tgttctcctg ctctgtgatg cacgaggccc tgcacaacca ctacacccaa     1320

gagtccctgt ctctgtcccc t                                               1341


<210>  81
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1280H-IgG4-P K439E amino acid sequence

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Arg Phe Asn Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Arg Lys Phe Tyr Val Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Lys Ser Val Tyr 
65                  70                  75                  80  


Val Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Ser Ile Lys Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser Leu Ser Pro 
        435                 440                 445         


<210>  82
<211>  366
<212>  DNA
<213>  Homo Sapiens

<400>  82
gaggtgcagc tggttgaatc tggcggcgga tttgttcagc ctggcggctc tctgagactg       60

agctgtgccg tgtccggctt ccggttcaac agctactgga tgtcctgggt ccgacaggcc      120

cctggcaaag gacttgagtg ggtcgccaac atcaaccagg acggcagccg gaagttttac      180

gtggcctctg tgaagggcag attcaccatg agccgggaca acgccgacaa aagcgtgtac      240

gtgcagatga acagcctgag agccgaggac accgccgtgt actattgtgc cagagagggc      300

tacagcagca tcaagtacta cggcatggac gtgtggggcc agggcacaac agtgacagtc      360

tcttct                                                                 366


<210>  83
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Arg Phe Asn Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Arg Lys Phe Tyr Val Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Asp Lys Ser Val Tyr 
65                  70                  75                  80  


Val Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Ser Ile Lys Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  84
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding N1441H-IgG4-P K439E heavy chain

<400>  84
gaagtgcagc tggttgaatc tggcggcgga tttgttcagc ctggcggctc tctgagactg       60

tcctgtgctg tgtccggctt ccggttcaac tcctactgga tgtcctgggt ccgacaggct      120

cctggcaaag gactggaatg ggtcgccaac atcaaccagg acggctcccg gaagttctac      180

gtggcctctg tgaagggcag attcaccatg tctcgggaca acgccgacaa gtccgtgtac      240

gtgcagatga actccctgag agccgaggac accgccgtgt actactgtgc tagagagggc      300

tactcctcca tcaagtacta cggcatggac gtgtggggcc agggcacaac cgtgacagtc      360

tcttccgctt ccaccaaggg acccagcgtt ttccctctgg ctccttgctc cagatccacc      420

tccgagtcta cagctgctct gggctgcctg gtcaaggact actttcctga gcctgtgacc      480

gtgtcctgga actctggcgc tctgacatct ggcgtgcaca cctttccagc tgtgctgcag      540

tcctccggcc tgtactctct gtcctctgtc gtgaccgtgc cttccagctc tctgggaacc      600

cagacctaca cctgtaatgt ggaccacaag ccttccaaca ccaaggtgga caagcgcgtg      660

gaatctaagt acggccctcc ttgtcctcca tgtcctgctc cagagtttct cggcggaccc      720

tccgtgtttc tgttccctcc aaagcctaag gacaccctga tgatctctcg gacccctgaa      780

gtgacctgcg tggtggtgga tgtgtcccaa gaggatcccg aggtgcagtt caattggtac      840

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gtacaactcc      900

acctacagag tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa cggcaaagag      960

tacaagtgca aggtgtccaa caagggcctg cctagctcca tcgaaaagac catctccaag     1020

gccaagggcc agcctcgaga accccaggtt tacaccctgc ctccaagcca agaggaaatg     1080

accaagaacc aggtgtccct gacctgtctc gtgaagggct tctacccctc cgatatcgcc     1140

gtggaatggg agtctaatgg ccagccagag aacaactaca agaccacacc tccagtgctg     1200

gactccgacg gctcattctt tctgtactcc aagctgacag tggacaagtc ccggtggcaa     1260

gagggcaacg tgttctcctg ctctgtgatg cacgaggccc tgcacaacca ctacacccaa     1320

gagtccctgt ctctgtcccc t                                               1341


<210>  85
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1441H-IgG4-P K439E amino acid sequence

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Arg Phe Asn Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Arg Lys Phe Tyr Val Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Asp Lys Ser Val Tyr 
65                  70                  75                  80  


Val Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Ser Ile Lys Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser Leu Ser Pro 
        435                 440                 445         


<210>  86
<211>  363
<212>  DNA
<213>  Homo Sapiens

<400>  86
caggttcagc tgattcagtc cggcgccaaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg cctctcggta caagttcacc tcctactaca tgcactgggt ccgacaggcc      120

cctggacaag gattggagtg gatgggcatc atcaacccca agtccggctc cacctcttac      180

gcccagaaat tccagggcag agtgaccatg accagagaca cctctacctc caccgtgtac      240

atggaactgt ccagcctgag atccgaggac accgccgtgt actactgtgc cagagatggc      300

tacggcagct tctccagact gatccagttg tggggccagg gcacactggt cacagtgtcc      360

tct                                                                    363


<210>  87
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  87

Gln Val Gln Leu Ile Gln Ser Gly Ala Lys Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Arg Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Lys Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Ser Phe Ser Arg Leu Ile Gln Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  88
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding T0999H-IgG4-P E356K heavy chain; T0999H 
       coding sequence underlined

<400>  88
caggttcagc tgattcagtc cggcgccaaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg cctctcggta caagttcacc tcctactaca tgcactgggt ccgacaggcc      120

cctggacaag gattggagtg gatgggcatc atcaacccca agtccggctc cacctcttac      180

gcccagaaat tccagggcag agtgaccatg accagagaca cctctacctc caccgtgtac      240

atggaactgt ccagcctgag atccgaggac accgccgtgt actactgtgc cagagatggc      300

tacggcagct tctccagact gatccagttg tggggccagg gcacactggt cacagtgtcc      360

tctgcttcca ccaagggacc cagcgtgttc cctctggctc cttgctccag atccacctcc      420

gagtctacag ctgctctggg ctgcctggtc aaggactact ttcctgagcc tgtgaccgtg      480

tcttggaact ctggcgctct gacatctggc gtgcacacct ttccagctgt gctgcagtcc      540

tccggcctgt actctctgtc ctctgtcgtg accgtgcctt ccagctctct gggaacccag      600

acctacacct gtaatgtgga ccacaagcct tccaacacca aggtggacaa gcgcgtggaa      660

tctaagtacg gccctccttg tcctccatgt cctgctccag agtttctcgg cggaccctcc      720

gtgtttctgt tccctccaaa gcctaaggac accctgatga tctctcggac ccctgaagtg      780

acctgcgtgg tggtggatgt gtcccaagag gatcccgagg tgcagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta caactccacc      900

tacagagtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac      960

aagtgcaagg tgtccaacaa gggcctgcct agctccatcg aaaagaccat ctccaaggcc     1020

aagggccagc ctcgagaacc ccaggtttac accctgcctc caagccagaa agagatgacc     1080

aagaaccagg tgtccctgac ctgcctcgtg aagggcttct acccttccga tatcgccgtg     1140

gaatgggaga gcaatggcca gccagagaac aactacaaga ccacacctcc tgtgctggac     1200

tccgatggct cattctttct gtactccaag ctgacagtgg acaagtcccg gtggcaagag     1260

ggcaacgtgt tctcctgctc tgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtctc tgtcccct                                                   1338


<210>  89
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T0999H-IgG4-P E356K amino acid sequence

<400>  89

Gln Val Gln Leu Ile Gln Ser Gly Ala Lys Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Arg Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Lys Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Ser Phe Ser Arg Leu Ile Gln Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Lys Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445     


<210>  90
<211>  363
<212>  DNA
<213>  Homo Sapiens

<400>  90
caggtgcagt tgatacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctagata cagcttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta aaagtggtag tacaagttac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatggg      300

tatggcagct cgtcccggtg cctccagctc tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  91
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  91

Gln Val Gln Leu Ile Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Arg Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Lys Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Ser Ser Ser Arg Cys Leu Gln Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  92
<211>  363
<212>  DNA
<213>  Homo Sapiens

<400>  92
caggtgcagt tgatacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctagata caagttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta aaagtggtag tacaagttac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatggg      300

tatggcagct tctcccggct gatccagctc tggggccagg gcaccctggt caccgtctcc      360

tca                                                                    363


<210>  93
<211>  121
<212>  PRT
<213>  Homo Sapiens

<400>  93

Gln Val Gln Leu Ile Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Arg Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Lys Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Ser Phe Ser Arg Leu Ile Gln Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  94
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid encoding T0736H-IgG4-P E356K heavy chain

<400>  94
caggttcagc tgattcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg cctctcggta caagttcacc tcctactaca tgcactgggt ccgacaggcc      120

cctggacaag gattggagtg gatgggcatc atcaacccca agtccggctc cacctcttac      180

gcccagaaat tccagggcag agtgaccatg accagagaca cctctacctc caccgtgtac      240

atggaactgt ccagcctgag atccgaggac accgccgtgt actactgtgc cagagatggc      300

tacggcagct tctccaggct gatccagttg tggggacagg gcacactggt caccgtgtcc      360

tctgcttcta ccaagggacc cagcgtgttc cctctggctc cttgctccag atccacctcc      420

gagtctacag ctgctctggg ctgcctggtc aaggactact ttcctgagcc tgtgaccgtg      480

tcttggaact ctggcgctct gacatctggc gtgcacacct ttccagctgt gctgcagtcc      540

tccggcctgt actctctgtc ctctgtcgtg accgtgcctt ccagctctct gggaacccag      600

acctacacct gtaatgtgga ccacaagcct tccaacacca aggtggacaa gcgcgtggaa      660

tctaagtacg gccctccttg tcctccatgt cctgctccag agtttctcgg cggaccctcc      720

gtgtttctgt tccctccaaa gcctaaggac accctgatga tctctcggac ccctgaagtg      780

acctgcgtgg tggtggatgt gtcccaagag gatcccgagg tgcagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta caactccacc      900

tacagagtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac      960

aagtgcaagg tgtccaacaa gggcctgcct agctccatcg aaaagaccat ctccaaggcc     1020

aagggccagc ctcgagaacc ccaggtttac accctgcctc caagccagaa agagatgacc     1080

aagaaccagg tgtccctgac ctgcctcgtg aagggcttct acccttccga tatcgccgtg     1140

gaatgggaga gcaatggcca gccagagaac aactacaaga ccacacctcc tgtgctggac     1200

tccgatggct cattctttct gtactccaag ctgacagtgg acaagtcccg gtggcaagag     1260

ggcaacgtgt tctcctgctc tgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtctc tgtcccct                                                   1338


<210>  95
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T0736H-IgG4-P E356K amino acid sequence

<400>  95

Gln Val Gln Leu Ile Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Arg Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Lys Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Gly Ser Phe Ser Arg Leu Ile Gln Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Lys Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445     


<210>  96
<211>  325
<212>  DNA
<213>  Homo Sapiens

<400>  96
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggagagac ggccaggatt       60

acctgtgggg gagacaacat tggaaggaaa agtgtgtact ggtaccagca gaagtcaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctgggt ccaactctgg gaacacggcg accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatggaagta gtgatcattg ggtgttcggc      300

ggagggacca agttgaccgt cctag                                            325


<210>  97
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  97

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Arg Lys Ser Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser Ser Asp His 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  98
<211>  642
<212>  DNA
<213>  Homo Sapiens

<400>  98
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggagagac ggccaggatt       60

acctgtgggg gagacaacat tggaaggaaa agtgtgtact ggtaccagca gaagtcaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctgggt ccaactctgg gaacacggcg accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatggaagta gtgatcattg ggtgttcggc      300

ggagggacca agttgaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccaccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctacctg      540

agcctgacgc ctgagcagtg gaagtcccac aaaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  99
<211>  214
<212>  PRT
<213>  Homo Sapiens

<400>  99

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Arg Lys Ser Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser Ser Asp His 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  100
<211>  321
<212>  DNA
<213>  Homo Sapiens

<400>  100
tacgtgctga cccagcctcc ttccgtgtct gttgctcctg gcgagacagc cagaatcacc       60

tgtggcggcg ataacatcgg ccggaagtcc gtgtactggt atcagcagaa gtccggccag      120

gctcctgtgc tggtcatcta ctacgactcc gaccggcctt ctggcatccc tgagagattc      180

tccggctcca actccggcaa taccgccaca ctgaccatct ccagagtgga agctggcgac      240

gaggccgact actactgcca agtgtgggac ggctcctctg accactgggt tttcggcgga      300

ggcaccaagc tgacagtgct g                                                321


<210>  101
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  101

Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Glu Thr 
1               5                   10                  15      


Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Arg Lys Ser Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr Tyr 
        35                  40                  45              


Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    50                  55                  60                  


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser Ser Asp His Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  102
<211>  639
<212>  DNA
<213>  Homo Sapiens

<400>  102
tacgtgctga cccagcctcc ttccgtgtct gttgctcctg gcgagacagc cagaatcacc       60

tgtggcggcg ataacatcgg ccggaagtcc gtgtactggt atcagcagaa gtccggccag      120

gctcctgtgc tggtcatcta ctacgactcc gaccggcctt ctggcatccc tgagagattc      180

tccggctcca actccggcaa taccgccaca ctgaccatct ccagagtgga agctggcgac      240

gaggccgact actactgcca agtgtgggac ggctcctctg accactgggt tttcggcgga      300

ggcaccaagc tgacagtgct gggacaacct aaggccgctc cttctgtgac cctgtttcct      360

ccatcctccg aggaactgca ggccaacaag gctaccctcg tgtgcctgat ctccgacttt      420

taccctggcg ctgtgaccgt ggcctggaag gctgatagtt ctcctgtgaa ggccggcgtg      480

gaaaccacca caccttccaa gcagtccaac aacaaatacg ccgcctcctc ctacctgtct      540

ctgacccctg aacagtggaa gtcccacaag tcctactctt gccaagtgac ccacgagggc      600

tccaccgtgg aaaagacagt ggctcctacc gagtgctcc                             639


<210>  103
<211>  213
<212>  PRT
<213>  Homo Sapiens

<400>  103

Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Glu Thr 
1               5                   10                  15      


Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Arg Lys Ser Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr Tyr 
        35                  40                  45              


Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    50                  55                  60                  


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser Ser Asp His Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  104
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 PE human heavy chain constant region

<400>  104

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  105
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 human heavy chain constant region with knobs-into-holes 
       mutations and hinge mutation. Type a (IgG4ra)

<400>  105

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  106
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 human heavy chain constant region with knobs-into-holes 
       mutations and hinge mutation. Type b (IgG4yb)

<400>  106

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Cys Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  107
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 human heavy chain constant region with P (hinge) mutation 
       and K439E

<400>  107

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro 
                325 


<210>  108
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 human heavy chain constant region with P (hinge) mutation 
       and E356K

<400>  108

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Lys Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro 
                325 


<210>  109
<211>  975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4-P K439E encoding nucleic acid

<400>  109
gcttccacca agggacccag cgttttccct ctggctcctt gctccagatc cacctccgag       60

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtcc      120

tggaactctg gcgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      180

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcca gctctctggg aacccagacc      240

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      300

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      360

tttctgttcc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      420

tgcgtggtgg tggatgtgtc ccaagaggat cccgaggtgc agttcaattg gtacgtggac      480

ggcgtggaag tgcacaatgc caagaccaag cctagagagg aacagtacaa ctccacctac      540

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      600

tgcaaggtgt ccaacaaggg cctgcctagc tccatcgaaa agaccatctc caaggccaag      660

ggccagcctc gagaacccca ggtttacacc ctgcctccaa gccaagagga aatgaccaag      720

aaccaggtgt ccctgacctg tctcgtgaag ggcttctacc cctccgatat cgccgtggaa      780

tgggagtcta atggccagcc agagaacaac tacaagacca cacctccagt gctggactcc      840

gacggctcat tctttctgta ctccaagctg acagtggaca agtcccggtg gcaagagggc      900

aacgtgttct cctgctctgt gatgcacgag gccctgcaca accactacac ccaagagtcc      960

ctgtctctgt cccct                                                       975


<210>  110
<211>  975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4-P E356K encoding nucleic acid

<400>  110
gcttccacca agggacccag cgtgttccct ctggctcctt gctccagatc cacctccgag       60

tctacagctg ctctgggctg cctggtcaag gactactttc ctgagcctgt gaccgtgtct      120

tggaactctg gcgctctgac atctggcgtg cacacctttc cagctgtgct gcagtcctcc      180

ggcctgtact ctctgtcctc tgtcgtgacc gtgccttcca gctctctggg aacccagacc      240

tacacctgta atgtggacca caagccttcc aacaccaagg tggacaagcg cgtggaatct      300

aagtacggcc ctccttgtcc tccatgtcct gctccagagt ttctcggcgg accctccgtg      360

tttctgttcc ctccaaagcc taaggacacc ctgatgatct ctcggacccc tgaagtgacc      420

tgcgtggtgg tggatgtgtc ccaagaggat cccgaggtgc agttcaattg gtacgtggac      480

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa ctccacctac      540

agagtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      600

tgcaaggtgt ccaacaaggg cctgcctagc tccatcgaaa agaccatctc caaggccaag      660

ggccagcctc gagaacccca ggtttacacc ctgcctccaa gccagaaaga gatgaccaag      720

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa      780

tgggagagca atggccagcc agagaacaac tacaagacca cacctcctgt gctggactcc      840

gatggctcat tctttctgta ctccaagctg acagtggaca agtcccggtg gcaagagggc      900

aacgtgttct cctgctctgt gatgcacgag gccctgcaca accactacac ccagaagtcc      960

ctgtctctgt cccct                                                       975


<210>  111
<211>  318
<212>  DNA
<213>  Homo Sapiens

<400>  111
ggacaaccta aggccgctcc ttctgtgacc ctgtttcctc catcctccga ggaactgcag       60

gccaacaagg ctaccctcgt gtgcctgatc tccgactttt accctggcgc tgtgaccgtg      120

gcctggaagg ctgatagttc tcctgtgaag gccggcgtgg aaaccaccac accttccaag      180

cagtccaaca acaaatacgc cgcctcctcc tacctgtctc tgacccctga acagtggaag      240

tcccacaagt cctactcttg ccaagtgacc cacgagggct ccaccgtgga aaagacagtg      300

gctcctaccg agtgctcc                                                    318


<210>  112
<211>  106
<212>  PRT
<213>  Homo Sapiens

<400>  112

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  113
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  113

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15      


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
            20                  25                  30          


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
        35                  40                  45              


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
    50                  55                  60                  


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
65                  70                  75                  80  


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
                85                  90                  95      


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105             


<210>  114
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  114

Thr Asp Ala Arg Cys 
1               5   


<210>  115
<211>  128
<212>  PRT
<213>  Homo Sapiens

<400>  115

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          


Ala Pro Gly Glu Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly 
        35                  40                  45              


Arg Lys Ser Val Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Ile Tyr Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly 
            100                 105                 110         


Ser Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  116
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  116

Gln Ala Gly Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln 
1               5                   10                  15      


Thr Ala Thr Leu Thr Cys Thr Gly Asn Ser Asn Asn Val Gly Asn Leu 
            20                  25                  30          


Gly Ala Ala Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu Leu 
        35                  40                  45              


Ser Tyr Arg Asn Asn Asn Arg Pro Ser Gly Ile Ser Glu Arg Phe Phe 
    50                  55                  60                  


Ala Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  117
<211>  108
<212>  PRT
<213>  Homo Sapiens

<400>  117

Gly Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln Thr Ala 
1               5                   10                  15      


Thr Leu Thr Cys Thr Gly Asn Ser Asn Asn Val Gly Asn Leu Gly Ala 
            20                  25                  30          


Ala Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu Leu Ser Tyr 
        35                  40                  45              


Arg Asn Asn Asn Arg Pro Ser Gly Ile Ser Glu Arg Phe Phe Ala Ser 
    50                  55                  60                  


Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Ser Ser Leu Ser Ala 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  118
<211>  296
<212>  DNA
<213>  Homo Sapiens

<400>  118
caggcagggc tgactcagcc accctcggtg tccaagggct tgagacagac cgccacactc       60

acctgcactg ggaacagcaa caatgttggc aaccaaggag cagcttggct gcagcagcac      120

cagggccacc ctcccaaact cctatcctac aggaataaca accggccctc agggatctca      180

gagagattat ctgcatccag gtcaggaaac acagcctccc tgaccattac tggactccag      240

cctgaggacg aggctgacta ttactgctca gcatgggaca gcagcctcag tgctca          296


<210>  119
<211>  296
<212>  DNA
<213>  Homo Sapiens

<400>  119
caggcagggc tgactcagcc accctcggtg tccaagggct tgagacagac cgccacactc       60

acctgcactg ggaacagcaa cattgttggc aaccaaggag cagcttggct gcagcagcac      120

cagggccacc ctcccaaact cctatcctac aggaataaca accggccctc agggatctca      180

gagagattct ctgcatccag gtcaggaaac acagcctccc tgaccattac tggactccag      240

cctgaggacg aggctgacta ttactgctca gcattggaca gcagcctcag tgctca          296


<210>  120
<211>  290
<212>  DNA
<213>  Homo Sapiens

<400>  120
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatcc                 290


<210>  121
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  121

Met Pro Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr His Ser Ala Val 
1               5                   10                  15      


Ser Val Val 
            


<210>  122
<211>  330
<212>  DNA
<213>  Homo Sapiens

<400>  122
caggcagggc tgactcagcc accctcggtg tccaagggct tgagacagac cgccacactc       60

acctgcactg ggaacagcaa caatgttggc aacctaggag cagcttggct gcagcagcac      120

cagggccacc ctcccaaact cctatcctac aggaataata accggccctc agggatctca      180

gagagattct ttgcatccag gtcaggaaac acagcctccc tgaccattac tggactccag      240

cctgaggacg aggctgacta ttactgctca gcatgggaca gcagcctcag tgcttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  123
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  123

Gln Ala Gly Leu Thr Gln Pro Pro Ser 
1               5                   


<210>  124
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  124

Gly Leu Thr Gln Pro Pro Ser 
1               5           


