               SEQUENCE LISTING

<110> Herantis Pharma Oyj

<120> RETRO-INVERSO PEPTIDES

<130> P4702EP00

<150> EP19218611.2
<151> 2019-12-20

<160> 66

<170> BiSSAP 1.3.6

<210> 1
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(17..20)

<400> 1
Met Arg Val Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu 
1               5                   10                  15      
Cys Arg Ala Cys Ala Glu Lys 
            20              

<210> 2
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(4..7)

<400> 2
Lys Glu Ala Cys Ala Arg Cys Glu Glu Gly Trp Ser His Leu Ile Gln 
1               5                   10                  15      
Lys Leu Glu Ala Val Arg Met 
            20              

<210> 3
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(17..20)

<400> 3
Leu Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr 
1               5                   10                  15      
Cys Lys Gly Cys Ala Glu Lys 
            20              

<210> 4
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(4..7)

<400> 4
Lys Glu Ala Cys Gly Lys Cys Thr Glu Gly Trp Asp Asp Leu Ile Lys 
1               5                   10                  15      
Lys Leu Glu Lys Val Arg Leu 
            20              

<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(4..7)

<400> 5
Gly Glu Glu Cys Arg Ala Cys Ala Glu Lys Thr 
1               5                   10      

<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(5..8)

<400> 6
Thr Lys Glu Ala Cys Ala Arg Cys Glu Glu Gly 
1               5                   10      

<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(4..7)

<400> 7
Gly Glu Thr Cys Lys Gly Cys Ala Glu Lys Ser 
1               5                   10      

<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(5..8)

<400> 8
Ser Lys Glu Ala Cys Gly Lys Cys Thr Glu Gly 
1               5                   10      

<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(4..8)

<400> 9
Gly Glu Glu Cys Arg Gly Ala Cys Ala Glu Lys Thr 
1               5                   10          

<210> 10
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(5..9)

<400> 10
Thr Lys Glu Ala Cys Ala Gly Arg Cys Glu Glu Gly 
1               5                   10          

<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(4..8)

<400> 11
Gly Glu Thr Cys Lys Gly Gly Cys Ala Glu Lys Ser 
1               5                   10          

<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(5..9)

<400> 12
Ser Lys Glu Ala Cys Gly Gly Lys Cys Thr Glu Gly 
1               5                   10          

<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(3..6)

<400> 13
Glu Glu Cys Arg Ala Cys Ala Glu Lys 
1               5                   

<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(4..7)

<400> 14
Lys Glu Ala Cys Ala Arg Cys Glu Glu 
1               5                   

<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(3..6)

<400> 15
Glu Thr Cys Lys Gly Cys Ala Glu Lys 
1               5                   

<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(4..7)

<400> 16
Lys Glu Ala Cys Gly Lys Cys Thr Glu 
1               5                   

<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(3..6)

<400> 17
Glu Glu Cys Arg Ala Cys Ala Glu 
1               5               

<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(3..6)

<400> 18
Glu Ala Cys Ala Arg Cys Glu Glu 
1               5               

<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Native sequence (L-aa)

<220> 
<221> DISULFID
<222> join(3..6)

<400> 19
Glu Thr Cys Lys Gly Cys Ala Glu 
1               5               

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Reversed sequence (D-aa)

<220> 
<221> DISULFID
<222> join(3..6)

<400> 20
Glu Ala Cys Gly Lys Cys Thr Glu 
1               5               

<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 2
<223> X1 = R, K, I, G, A or S

<220> 
<221> VARIANT
<222> 3
<223> X2 = absent, G, A, R, K, I or S

<220> 
<221> DISULFID
<222> 4
<223> X3 = A, G or S

<400> 21
Cys Xaa Xaa Xaa Cys 
1               5   

<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 2
<223> X4 = E, T, V, D, M or G

<220> 
<221> VARIANT
<222> 4
<223> X1 = R, K, I, G, A or S

<220> 
<221> VARIANT
<222> 5
<223> X2 = absent, G, A, R, K, I, or S

<220> 
<221> VARIANT
<222> 6
<223> X3 = A, G or S

<400> 22
Glu Xaa Cys Xaa Xaa Xaa Cys Ala Glu 
1               5                   

<210> 23
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 1
<223> X5 = absent, H, D, Q, R, Y, N or S

<220> 
<221> VARIANT
<222> 2
<223> X6 = absent, S, D, G, N or R

<220> 
<221> VARIANT
<222> 3
<223> X7 = absent or W

<220> 
<221> VARIANT
<222> 4
<223> X8 = absent or G

<220> 
<221> VARIANT
<222> 6
<223> X4 = E, T, V, D, M or G

<220> 
<221> VARIANT
<222> 8
<223> X1 = R, K, I, G, A or S

<220> 
<221> VARIANT
<222> 9
<223> X2 = absent, G, A R, K, I or S

<220> 
<221> VARIANT
<222> 10
<223> X3 = A, G or S

<220> 
<221> VARIANT
<222> 14
<223> X9 = absent or K

<220> 
<221> VARIANT
<222> 15
<223> X10 = absent, T, S, A, I or N

<220> 
<221> VARIANT
<222> 16
<223> X11 = absent, D or E

<400> 23
Xaa Xaa Xaa Xaa Glu Xaa Cys Xaa Xaa Xaa Cys Ala Glu Xaa Xaa Xaa 
1               5                   10                  15      



<210> 24
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 1
<223> X12 = absent, L, I or V

<220> 
<221> VARIANT
<222> 2
<223> X13 = absent or D

<220> 
<221> VARIANT
<222> 3
<223> X14 = absent, L or W

<220> 
<221> VARIANT
<222> 4
<223> X15 = absent, A, S, T, E or N

<220> 
<221> VARIANT
<222> 5
<223> X16 = absent, S or T

<220> 
<221> VARIANT
<222> 6
<223> X17 = absent, V or D

<220> 
<221> VARIANT
<222> 7
<223> X18 = absent, D or A

<220> 
<221> VARIANT
<222> 8
<223> X19 = absent or L

<220> 
<221> VARIANT
<222> 9
<223> X20 = absent, R, K, S or W

<220> 
<221> VARIANT
<222> 10
<223> X21 = absent or K

<220> 
<221> VARIANT
<222> 11
<223> X22 = absent, M, L, I or V

<220> 
<221> VARIANT
<222> 12
<223> X23 = absent or R

<220> 
<221> VARIANT
<222> 13
<223> X24 = A, K, T, L or V

<220> 
<221> VARIANT
<222> 18
<223> X25 = Q, K or R

<220> 
<221> VARIANT
<222> 19
<223> X26 = I or V

<220> 
<221> VARIANT
<222> 21
<223> X5 = H, D, Q, R, Y, N or S

<220> 
<221> VARIANT
<222> 22
<223> X6 = absent, S, D, G, N or R

<220> 
<221> VARIANT
<222> 23
<223> X7 = absent or W

<220> 
<221> VARIANT
<222> 24
<223> X8 = absent or G

<220> 
<221> VARIANT
<222> 26
<223> X4 = E, T, V, D, M or G

<220> 
<221> VARIANT
<222> 28
<223> X1 = R, K, I, G, A or S

<220> 
<221> VARIANT
<222> 29
<223> X2 = absent, G, A, R, K, I or S

<220> 
<221> VARIANT
<222> 30
<223> X3 = A, G or S

<220> 
<221> VARIANT
<222> 34
<223> X9 = absent or K

<220> 
<221> VARIANT
<222> 35
<223> X10 = absent, or T, S, A, I or N

<220> 
<221> VARIANT
<222> 36
<223> X11 = absent, D or E

<400> 24
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Glu Leu 
1               5                   10                  15      
Lys Xaa Ile Leu Xaa Xaa Xaa Xaa Glu Xaa Cys Xaa Xaa Xaa Cys Ala 
            20                  25                  30          
Glu Xaa Xaa Xaa 
        35      

<210> 25
<211> 37
<212> PRT
<213> Homo sapiens


<220> 
<223> native human CDNF peptide

<400> 25
Arg Val Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys 
1               5                   10                  15      
Arg Ala Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Gln Glu Leu 
            20                  25                  30          
Ala Pro Lys Tyr Ala 
        35          

<210> 26
<211> 37
<212> PRT
<213> Homo sapiens


<220> 
<223> native human MANF peptide

<400> 26
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
1               5                   10                  15      
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
            20                  25                  30          
Met Pro Lys Tyr Ala 
        35          

<210> 27
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 1
<223> X16 = absent, S or T

<220> 
<221> VARIANT
<222> 2
<223> X17 = absent, V or D

<220> 
<221> VARIANT
<222> 3
<223> X18 = absent, D or A

<220> 
<221> VARIANT
<222> 4
<223> X19 = absent or L

<220> 
<221> VARIANT
<222> 5
<223> X20 = absent, R, K, S or W

<220> 
<221> VARIANT
<222> 6
<223> X21 = absent or K

<220> 
<221> VARIANT
<222> 7
<223> X22 = absent, M, L, I or V

<220> 
<221> VARIANT
<222> 8
<223> X23 = absent or R

<220> 
<221> VARIANT
<222> 10
<223> X24 = A, K, T, L or V

<220> 
<221> VARIANT
<222> 14
<223> X25 = Q, K or R

<220> 
<221> VARIANT
<222> 15
<223> X26 = I or V

<220> 
<221> VARIANT
<222> 17
<223> X5 = absent, H, D, Q, R, Y, N or S

<220> 
<221> VARIANT
<222> 18
<223> X6 = absent, S, D, G, N or R

<220> 
<221> VARIANT
<222> 19
<223> X7 = absent or W

<220> 
<221> VARIANT
<222> 20
<223> X8 = absent or G

<220> 
<221> VARIANT
<222> 22
<223> X4 = E, T, V, D, M or G

<220> 
<221> VARIANT
<222> 24
<223> X1 = R, K, I, G, A or S

<220> 
<221> VARIANT
<222> 25
<223> X2 = absent, G, A, R, K, I or S

<220> 
<221> VARIANT
<222> 26
<223> X3 = A, G or S

<220> 
<221> VARIANT
<222> 30
<223> X9 = absent or K

<220> 
<221> VARIANT
<222> 31
<223> X10 = absent, T, S, A, I or N

<220> 
<221> VARIANT
<222> 32
<223> X11 = absent, D or E

<400> 27
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Glu Leu Lys Xaa Xaa Leu 
1               5                   10                  15      
Xaa Xaa Xaa Xaa Glu Xaa Cys Xaa Xaa Xaa Cys Ala Glu Xaa Xaa Xaa 
            20                  25                  30          



<210> 28
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 1
<223> X15 = absent, A, S, T, E or N

<220> 
<221> VARIANT
<222> 2
<223> X16 = absent, S or T

<220> 
<221> VARIANT
<222> 3
<223> X17 = absent, V or D

<220> 
<221> VARIANT
<222> 4
<223> X18 = absent, D or A

<220> 
<221> VARIANT
<222> 5
<223> X19 = absent or L

<220> 
<221> VARIANT
<222> 6
<223> X20 = absent, R, K, S or W

<220> 
<221> VARIANT
<222> 7
<223> X21 = absent or K

<220> 
<221> VARIANT
<222> 8
<223> X22 = absent, M, L, I or V

<220> 
<221> VARIANT
<222> 9
<223> X23 = absent or R

<220> 
<221> VARIANT
<222> 9
<223> X23 = absent or R

<220> 
<221> VARIANT
<222> 11
<223> X24 = A, K, T, L or V

<220> 
<221> VARIANT
<222> 15
<223> X25 = Q, K or R

<220> 
<221> VARIANT
<222> 16
<223> X26 = I or V

<220> 
<221> VARIANT
<222> 18
<223> X5 = absent, H, D, Q, R, Y, N or S

<220> 
<221> VARIANT
<222> 19
<223> X6 = absent, S, D, G, N or R

<220> 
<221> VARIANT
<222> 20
<223> X7 = absent or W

<220> 
<221> VARIANT
<222> 21
<223> X8 = absent or G

<220> 
<221> VARIANT
<222> 23
<223> X4 = E, T, V, D, M or G

<220> 
<221> VARIANT
<222> 25
<223> X1 = R, K, I, G, A or S

<220> 
<221> VARIANT
<222> 26
<223> X2 = absent, G, A, R, K, I or S

<220> 
<221> VARIANT
<222> 27
<223> X3 = A, G or S

<220> 
<221> VARIANT
<222> 31
<223> X9 = absent or K

<400> 28
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Glu Leu Lys Xaa Xaa 
1               5                   10                  15      
Leu Xaa Xaa Xaa Xaa Glu Xaa Cys Xaa Xaa Xaa Cys Ala Glu Xaa Xaa 
            20                  25                  30          



<210> 29
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 1
<223> X14 = absent, L or W

<220> 
<221> VARIANT
<222> 2
<223> X15 = absent, A, S, T, E or N

<220> 
<221> VARIANT
<222> 3
<223> X16 = absent, S or T

<220> 
<221> VARIANT
<222> 4
<223> X17 = absent, V or D

<220> 
<221> VARIANT
<222> 5
<223> X18 = absent, D or A

<220> 
<221> VARIANT
<222> 6
<223> X19 = absent or L

<220> 
<221> VARIANT
<222> 7
<223> X20 = absent, R, K, S or W

<220> 
<221> VARIANT
<222> 8
<223> X21 = absent or K

<220> 
<221> VARIANT
<222> 9
<223> X22 = absent, M, L, I or V

<220> 
<221> VARIANT
<222> 10
<223> X23 = absent or R

<220> 
<221> VARIANT
<222> 12
<223> X24 = A, K, T, L or V

<220> 
<221> VARIANT
<222> 16
<223> X25 = Q, K or R

<220> 
<221> VARIANT
<222> 17
<223> X26 = I or V

<220> 
<221> VARIANT
<222> 19
<223> X5 = absent, H, D, Q, R, Y, N or S

<220> 
<221> VARIANT
<222> 20
<223> X6 = absent, S, D, G, N or R

<220> 
<221> VARIANT
<222> 21
<223> X7 = absent or W

<220> 
<221> VARIANT
<222> 22
<223> X8 = absent or G

<220> 
<221> VARIANT
<222> 24
<223> X4 = E, T, V, D, M or G

<220> 
<221> VARIANT
<222> 26
<223> X1 = R, K, I, G, A or S

<220> 
<221> VARIANT
<222> 27
<223> X2 = absent, G, A, R, K, I or S

<220> 
<221> VARIANT
<222> 28
<223> X3 = A, G or S

<220> 
<221> VARIANT
<222> 32
<223> X9 = absent or K

<400> 29
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Glu Leu Lys Xaa 
1               5                   10                  15      
Xaa Leu Xaa Xaa Xaa Xaa Glu Xaa Cys Xaa Xaa Xaa Cys Ala Glu Xaa 
            20                  25                  30          



<210> 30
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 1
<223> X13 = absent or D

<220> 
<221> VARIANT
<222> 2
<223> X14 = absent, L or W

<220> 
<221> VARIANT
<222> 3
<223> X15 = absent, A, S, T, E or N

<220> 
<221> VARIANT
<222> 4
<223> X16 = absent, S or T

<220> 
<221> VARIANT
<222> 5
<223> X17 = absent, V or D

<220> 
<221> VARIANT
<222> 6
<223> X18 = absent, D or A

<220> 
<221> VARIANT
<222> 7
<223> X19 = absent or L

<220> 
<221> VARIANT
<222> 8
<223> X20 = absent, R, K, S or W

<220> 
<221> VARIANT
<222> 9
<223> X21 = absent or K

<220> 
<221> VARIANT
<222> 10
<223> X22 = absent, M, L, I or V

<220> 
<221> VARIANT
<222> 11
<223> X23 = absent or R

<220> 
<221> VARIANT
<222> 13
<223> X24 = A, K, T, L or V

<220> 
<221> VARIANT
<222> 17
<223> X25 = Q, K or R

<220> 
<221> VARIANT
<222> 18
<223> X26 = I or V

<220> 
<221> VARIANT
<222> 20
<223> X5 = absent, H, D, Q, R, Y, N or S

<220> 
<221> VARIANT
<222> 21
<223> X6 = absent, S, D, G, N or R

<220> 
<221> VARIANT
<222> 22
<223> X7 = absent or W

<220> 
<221> VARIANT
<222> 23
<223> X8 = absent or G

<220> 
<221> VARIANT
<222> 25
<223> X4 = E, T, V, D, M or G

<220> 
<221> VARIANT
<222> 27
<223> X1 = R, K, I, G, A or S

<220> 
<221> VARIANT
<222> 28
<223> X2 = absent, G, A, R, K, I or S

<220> 
<221> VARIANT
<222> 29
<223> X3 = A, G or S

<400> 30
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Glu Leu Lys 
1               5                   10                  15      
Xaa Xaa Leu Xaa Xaa Xaa Xaa Glu Xaa Cys Xaa Xaa Xaa Cys Ala Glu 
            20                  25                  30          



<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<400> 31
Lys Asp Glu Leu 
1               

<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<400> 32
Cys Arg Ala Cys 
1               

<210> 33
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<400> 33
Cys Lys Gly Cys 
1               

<210> 34
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<220> 
<221> VARIANT
<222> 2
<223> X1 = K or R

<220> 
<221> VARIANT
<222> 3
<223> X2 = G or A

<400> 34
Cys Xaa Xaa Cys 
1               

<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<400> 35
Glu Thr Cys Lys Gly Cys Ala Glu 
1               5               

<210> 36
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> peptide

<400> 36
Thr Cys Lys Gly Cys Ala 
1               5       

<210> 37
<211> 187
<212> PRT
<213> Homo sapiens


<220> 
<223> full length CDNF (NCBI Reference Sequence: NP_001025125.2)

<400> 37
Met Trp Cys Ala Ser Pro Val Ala Val Val Ala Phe Cys Ala Gly Leu 
1               5                   10                  15      
Leu Val Ser His Pro Val Leu Thr Gln Gly Gln Glu Ala Gly Gly Arg 
            20                  25                  30          
Pro Gly Ala Asp Cys Glu Val Cys Lys Glu Phe Leu Asn Arg Phe Tyr 
        35                  40                  45              
Lys Ser Leu Ile Asp Arg Gly Val Asn Phe Ser Leu Asp Thr Ile Glu 
    50                  55                  60                  
Lys Glu Leu Ile Ser Phe Cys Leu Asp Thr Lys Gly Lys Glu Asn Arg 
65                  70                  75                  80  
Leu Cys Tyr Tyr Leu Gly Ala Thr Lys Asp Ala Ala Thr Lys Ile Leu 
                85                  90                  95      
Ser Glu Val Thr Arg Pro Met Ser Val His Met Pro Ala Met Lys Ile 
            100                 105                 110         
Cys Glu Lys Leu Lys Lys Leu Asp Ser Gln Ile Cys Glu Leu Lys Tyr 
        115                 120                 125             
Glu Lys Thr Leu Asp Leu Ala Ser Val Asp Leu Arg Lys Met Arg Val 
    130                 135                 140                 
Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys Arg Ala 
145                 150                 155                 160 
Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Gln Glu Leu Ala Pro 
                165                 170                 175     
Lys Tyr Ala Ala Thr His Pro Lys Thr Glu Leu 
            180                 185         

<210> 38
<211> 182
<212> PRT
<213> Homo sapiens


<220> 
<223> full length MANF (NCBI Reference Sequence: NP_006001.5)

<400> 38
Met Arg Arg Met Trp Ala Thr Gln Gly Leu Ala Val Ala Leu Ala Leu 
1               5                   10                  15      
Ser Val Leu Pro Gly Ser Arg Ala Leu Arg Pro Gly Asp Cys Glu Val 
            20                  25                  30          
Cys Ile Ser Tyr Leu Gly Arg Phe Tyr Gln Asp Leu Lys Asp Arg Asp 
        35                  40                  45              
Val Thr Phe Ser Pro Ala Thr Ile Glu Asn Glu Leu Ile Lys Phe Cys 
    50                  55                  60                  
Arg Glu Ala Arg Gly Lys Glu Asn Arg Leu Cys Tyr Tyr Ile Gly Ala 
65                  70                  75                  80  
Thr Asp Asp Ala Ala Thr Lys Ile Ile Asn Glu Val Ser Lys Pro Leu 
                85                  90                  95      
Ala His His Ile Pro Val Glu Lys Ile Cys Glu Lys Leu Lys Lys Lys 
            100                 105                 110         
Asp Ser Gln Ile Cys Glu Leu Lys Tyr Asp Lys Gln Ile Asp Leu Ser 
        115                 120                 125             
Thr Val Asp Leu Lys Lys Leu Arg Val Lys Glu Leu Lys Lys Ile Leu 
    130                 135                 140                 
Asp Asp Trp Gly Glu Thr Cys Lys Gly Cys Ala Glu Lys Ser Asp Tyr 
145                 150                 155                 160 
Ile Arg Lys Ile Asn Glu Leu Met Pro Lys Tyr Ala Pro Lys Ala Ala 
                165                 170                 175     
Ser Ala Arg Thr Asp Leu 
            180         

<210> 39
<211> 49
<212> PRT
<213> Homo sapiens


<400> 39
Thr Leu Asp Leu Ala Ser Val Asp Leu Arg Lys Met Arg Val Ala Glu 
1               5                   10                  15      
Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys Arg Ala Cys Ala 
            20                  25                  30          
Glu Lys Thr Asp Tyr Val Asn Leu Ile Gln Glu Leu Ala Pro Lys Tyr 
        35                  40                  45              
Ala 
    

<210> 40
<211> 37
<212> PRT
<213> Homo sapiens


<400> 40
Arg Val Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys 
1               5                   10                  15      
Arg Ala Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Gln Glu Leu 
            20                  25                  30          
Ala Pro Lys Tyr Ala 
        35          

<210> 41
<211> 35
<212> PRT
<213> Homo sapiens


<400> 41
Thr Leu Asp Leu Ala Ser Val Asp Leu Arg Lys Met Arg Val Ala Glu 
1               5                   10                  15      
Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys Arg Ala Cys Ala 
            20                  25                  30          
Glu Lys Thr 
        35  

<210> 42
<211> 32
<212> PRT
<213> Homo sapiens


<400> 42
Leu Ala Ser Val Asp Leu Arg Lys Met Arg Val Ala Glu Leu Lys Gln 
1               5                   10                  15      
Ile Leu His Ser Trp Gly Glu Glu Cys Arg Ala Cys Ala Glu Lys Thr 
            20                  25                  30          



<210> 43
<211> 49
<212> PRT
<213> Homo sapiens


<400> 43
Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu Arg Val Lys Glu 
1               5                   10                  15      
Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys Lys Gly Cys Ala 
            20                  25                  30          
Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu Met Pro Lys Tyr 
        35                  40                  45              
Ala 
    

<210> 44
<211> 37
<212> PRT
<213> Homo sapiens


<400> 44
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
1               5                   10                  15      
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
            20                  25                  30          
Met Pro Lys Tyr Ala 
        35          

<210> 45
<211> 35
<212> PRT
<213> Homo sapiens


<400> 45
Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu Arg Val Lys Glu 
1               5                   10                  15      
Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys Lys Gly Cys Ala 
            20                  25                  30          
Glu Lys Ser 
        35  

<210> 46
<211> 32
<212> PRT
<213> Homo sapiens


<400> 46
Leu Ser Thr Val Asp Leu Lys Lys Leu Arg Val Lys Glu Leu Lys Lys 
1               5                   10                  15      
Ile Leu Asp Asp Trp Gly Glu Thr Cys Lys Gly Cys Ala Glu Lys Ser 
            20                  25                  30          



<210> 47
<211> 61
<212> PRT
<213> Homo sapiens


<220> 
<223> Human CDNF (NP_001025125.2)

<400> 47
Lys Tyr Glu Lys Thr Leu Asp Leu Ala Ser Val Asp Leu Arg Lys Met 
1               5                   10                  15      
Arg Val Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys 
            20                  25                  30          
Arg Ala Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Gln Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Ala Ala Thr His Pro Lys Thr Glu Leu 
    50                  55                  60      

<210> 48
<211> 61
<212> PRT
<213> Equus


<220> 
<223> Horse CDNF (XP_001498617.2)

<400> 48
Lys Tyr Glu Lys Lys Leu Asp Leu Ala Ser Val Asp Leu Leu Lys Met 
1               5                   10                  15      
Arg Val Ala Glu Leu Lys Gln Ile Leu Asn Ser Trp Gly Glu Glu Cys 
            20                  25                  30          
Arg Ala Cys Ala Glu Lys Ser Asp Tyr Val Asn Leu Ile Lys Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Ala Ala Met His Pro Lys Thr Glu Leu 
    50                  55                  60      

<210> 49
<211> 61
<212> PRT
<213> Bos


<220> 
<223> Bison CDNF (XP_010858254.1)

<400> 49
Lys Tyr Glu Lys Lys Leu Asp Leu Ala Ser Val Asp Leu Ser Lys Met 
1               5                   10                  15      
Arg Val Ala Glu Leu Lys Gln Ile Leu His Gly Trp Gly Glu Glu Cys 
            20                  25                  30          
Arg Ala Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Lys Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Ala Ala Thr His Pro Gln Thr Glu Leu 
    50                  55                  60      

<210> 50
<211> 61
<212> PRT
<213> Sus


<220> 
<223> Pig CDNF (XP_003130787.1)

<400> 50
Lys Tyr Glu Lys Lys Leu Asp Leu Ala Ser Val Asp Leu Ser Lys Met 
1               5                   10                  15      
Arg Val Ala Glu Leu Lys Gln Ile Leu Tyr Ser Trp Gly Glu Glu Cys 
            20                  25                  30          
Arg Ala Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Lys Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Thr Glu Thr Pro Pro Gln Thr Glu Leu 
    50                  55                  60      

<210> 51
<211> 61
<212> PRT
<213> Canis


<220> 
<223> Dog CDNF (XP_848954.2)

<400> 51
Lys Tyr Glu Lys Lys Leu Asp Leu Ala Ser Val Asp Leu Ser Lys Met 
1               5                   10                  15      
Arg Val Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys 
            20                  25                  30          
Ile Ala Cys Ala Glu Lys Thr Asp Tyr Val Asn Leu Ile Thr Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Ala Ala Ala His Pro Lys Thr Glu Leu 
    50                  55                  60      

<210> 52
<211> 61
<212> PRT
<213> Musculus


<220> 
<223> Mouse CDNF (NP_808315.1)

<400> 52
Lys Tyr Gly Lys Lys Leu Asp Leu Ala Ser Val Asp Leu Trp Lys Met 
1               5                   10                  15      
Arg Val Ala Glu Leu Lys Gln Ile Leu Gln Arg Trp Gly Glu Glu Cys 
            20                  25                  30          
Arg Ala Cys Ala Glu Lys Ser Asp Tyr Val Asn Leu Ile Arg Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Val Glu Ile Tyr Pro Gln Thr Glu Leu 
    50                  55                  60      

<210> 53
<211> 61
<212> PRT
<213> Cricetus


<220> 
<223> Hamster CDNF (XP_027261009.1)

<400> 53
Asn Tyr Glu Lys Lys Leu Asp Leu Ala Ser Val Asp Leu Trp Lys Met 
1               5                   10                  15      
Arg Asp Ala Glu Leu Lys Gln Ile Leu His Ser Trp Gly Glu Glu Cys 
            20                  25                  30          
Arg Ala Cys Ala Glu Lys Asn Asp Tyr Val Asn Leu Ile Lys Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Val Glu Ile His Pro Gln Ile Glu Leu 
    50                  55                  60      

<210> 54
<211> 61
<212> PRT
<213> Alligator


<220> 
<223> Alligator CDNF (XP_019343086.1)

<400> 54
Lys Tyr Glu Arg Lys Leu Asp Leu Thr Ser Val Asp Leu Ser Lys Met 
1               5                   10                  15      
Arg Val Ala Glu Leu Arg Lys Ile Leu Asp Ser Trp Gly Glu Val Cys 
            20                  25                  30          
Lys Ala Cys Ile Glu Lys Thr Glu Phe Val Asn Leu Ile Lys Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Ala Pro Pro Asn Ser Arg Ala Asp Leu 
    50                  55                  60      

<210> 55
<211> 61
<212> PRT
<213> Delphinus


<220> 
<223> Dolphin CDNF (XP_026977721.1)

<400> 55
Lys Tyr Glu Lys Lys Leu Asp Leu Ala Ser Val Asp Leu Ser Lys Met 
1               5                   10                  15      
Arg Val Ala Glu Leu Lys Gln Ile Leu Tyr Ser Trp Gly Glu Glu Cys 
            20                  25                  30          
Arg Ala Cys Val Glu Lys Thr Asp Tyr Val Asn Leu Ile Lys Glu Leu 
        35                  40                  45              
Ala Pro Lys Tyr Thr Ala Thr Tyr Pro Lys Thr Glu Leu 
    50                  55                  60      

<210> 56
<211> 65
<212> PRT
<213> Danio rerio


<220> 
<223> Zebrafish CDNF (NP_001116753.1)

<400> 56
Arg Tyr Glu Arg Leu Val Leu Asp Trp Ser Thr Asp Ala Leu Ser Lys 
1               5                   10                  15      
Met Arg Ala Leu Glu Leu Lys Arg Val Leu Ala Ser Trp Gly Glu Glu 
            20                  25                  30          
Cys Arg Ala Cys Leu Glu Lys Ser Glu Phe Ile Ala Leu Ile Gln Glu 
        35                  40                  45              
Val Ala Pro Lys His Ser Ala Ser Glu His Arg Ala His Thr Glu Glu 
    50                  55                  60                  
Phe 
65  

<210> 57
<211> 63
<212> PRT
<213> Homo sapiens


<220> 
<223> Human MANF (NP_006001.5)

<400> 57
Lys Tyr Asp Lys Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ala Arg Thr Asp Leu 
    50                  55                  60              

<210> 58
<211> 63
<212> PRT
<213> Equus


<220> 
<223> Horse MANF (NP_001184244.1)

<400> 58
Lys Tyr Asp Lys Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ser Arg Thr Asp Leu 
    50                  55                  60              

<210> 59
<211> 63
<212> PRT
<213> Bison


<220> 
<223> Bison MANF (XP_010850093.1)

<400> 59
Lys Tyr Asp Lys Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ser Arg Thr Asp Leu 
    50                  55                  60              

<210> 60
<211> 63
<212> PRT
<213> Sus


<220> 
<223> Pig MANF (NP_001231584.1)

<400> 60
Lys Tyr Asp Lys Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ser Arg Thr Asp Leu 
    50                  55                  60              

<210> 61
<211> 63
<212> PRT
<213> Canis


<220> 
<223> Dog MANF (XP_003639808.2)

<400> 61
Lys Tyr Asp Lys Gln Ile Asp Leu Arg Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Arg Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ser Arg Thr Asp Leu 
    50                  55                  60              

<210> 62
<211> 63
<212> PRT
<213> Musculus


<220> 
<223> Mouse MANF (NP_083379.2)

<400> 62
Lys Tyr Asp Lys Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Met Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ala Arg Thr Asp Leu 
    50                  55                  60              

<210> 63
<211> 63
<212> PRT
<213> Cricetus


<220> 
<223> Hamster MANF (RLQ67668)

<400> 63
Lys Tyr Asp Lys Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Met Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ala Arg Thr Asp Leu 
    50                  55                  60              

<210> 64
<211> 63
<212> PRT
<213> Alligator


<220> 
<223> Alligator MANF (XP_014455597.1)

<400> 64
Lys Tyr Asp Lys Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ser Arg Thr Asp Leu 
    50                  55                  60              

<210> 65
<211> 63
<212> PRT
<213> Delphinus


<220> 
<223> Dolphin MANF (XP_026976745.1)

<400> 65
Lys Tyr Asp Lys Gln Ile Asp Leu Ser Thr Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Arg Val Lys Glu Leu Lys Lys Ile Leu Asp Asp Trp Gly Glu Thr Cys 
            20                  25                  30          
Lys Gly Cys Ala Glu Lys Ser Asp Tyr Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Lys Ala Ala Ser Ser Arg Thr Asp Leu 
    50                  55                  60              

<210> 66
<211> 63
<212> PRT
<213> Danio rerio


<220> 
<223> Zebrafish MANF (NP_001070097.1)

<400> 66
Lys Tyr Asp Lys Gln Val Asp Leu Ser Ser Val Asp Leu Lys Lys Leu 
1               5                   10                  15      
Lys Val Lys Asp Leu Lys Lys Ile Leu Glu Glu Trp Gly Glu Ser Cys 
            20                  25                  30          
Lys Gly Cys Val Glu Lys Ser Asp Phe Ile Arg Lys Ile Asn Glu Leu 
        35                  40                  45              
Met Pro Lys Tyr Ala Pro Ser Ala Ala Lys Ala Arg Thr Asp Leu 
    50                  55                  60              

