                         SEQUENCE LISTING

<110>  Bracco Imaging SpA
 
<120>  ANTI-HER2 POLYPEPTIDES DERIVATIVES AS NEW DIAGNOSTIC MOLECULAR 
       PROBES

<130>  B0724

<150>  EP19217647.7
<151>  2019-12-18

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  64
<212>  PRT
<213>  Sulfolobus acidocaldarius

<400>  1

Val Lys Val Lys Phe Trp Gly Ala Gly Val Glu Lys Glu Val Asp Thr 
1               5                   10                  15      


Ser Lys Ile Thr Trp Val Thr Arg Ser Gly Lys Tyr Val Ile Phe Thr 
            20                  25                  30          


Tyr Asp Asp Asn Gly Lys Ala Gly Pro Gly Arg Val Pro Glu Lys Asp 
        35                  40                  45              


Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys 
    50                  55                  60                  


<210>  2
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered HER2 binding polypeptide

<400>  2

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Trp Gly Ala Gly Val Glu Lys Glu Val Asp Thr Ser Lys Ile Thr 
            20                  25                  30          


Trp Val Thr Arg Ser Gly Lys Tyr Val Ile Phe Thr Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Ala Gly Pro Gly Arg Val Pro Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Cys 
65                  70                  75          


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic 6xHis Tag derivative

<400>  3

Met Arg Gly Ser His His His His His His Gly Ser 
1               5                   10          


<210>  4
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered HER2 binding polypeptide

<400>  4

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Trp Gly Ala Gly Val Glu Lys Glu Val Asp Thr Ser Lys Ile Thr 
            20                  25                  30          


Trp Val Thr Arg Ser Gly Lys Tyr Val Ile Phe Thr Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Ala Gly Pro Gly Arg Val Pro Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys 
65                  70                  75      


<210>  5
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered HER2 binding polypeptide

<400>  5

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Trp Gly Ala Gly Val Glu Lys Glu Val Asp Thr Ser Lys Ile Thr 
            20                  25                  30          


Trp Val Thr Arg Ser Gly Lys Tyr Val Ile Phe Thr Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Ala Gly Pro Gly Arg Val Pro Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe Gly Gly Ser Leu Ala Ala 
                85                  90                  95      


Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg 
            100                 105                 110         


His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro 
        115                 120                 125             


Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn 
    130                 135                 140                 


Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly 
145                 150                 155                 160 


Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu 
                165                 170                 175     


Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly 
            180                 185                 190         


Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Gly Pro Ala Asp Ser Gly 
        195                 200                 205             


Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly 
    210                 215                 220                 


Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr 
225                 230                 235                 240 


Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr 
                245                 250                 255     


Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile 
            260                 265                 270         


Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp 
        275                 280                 285             


Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala 
    290                 295                 300                 


Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu 
305                 310                 315                 320 


Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr 
                325                 330                 335     


Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu 
            340                 345                 350         


Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu 
        355                 360                 365             


Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu 
    370                 375                 380                 


Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val 
385                 390                 395                 400 


Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile 
                405                 410                 415     


Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Lys Asp 
            420                 425                 430         


Glu Leu 
        


