                         SEQUENCE LISTING

<110>  Janssen Pharmaceutica NV
       Johnson & Johnson (China) Investment Ltd.

 
<120>  SUBSTITUTED STRAIGHT CHAIN SPIRO DERIVATIVES

<130>  P2020TC1423

<150>  PCT/CN2019/126760
<151>  2019-12-19

<150>  62/961775
<151>  2020-01-16

<150>  PCT/CN2020/126595
<151>  2020-11-04 

<160>  1    

<170>  PatentIn version 3.5

<210>  1
<211>  616
<212>  PRT
<213>  Artificial Sequence

<400>  1

Met Gly Leu Lys Ala Ala Gln Lys Thr Leu Phe Pro Leu Arg Ser Ile 
1               5                   10                  15     
 

Asp Asp Val Val Arg Leu Phe Ala Ala Glu Leu Gly Arg Glu Glu Pro 
            20                  25                  30          


Asp Leu Val Leu Leu Ser Leu Val Leu Gly Phe Val Glu His Phe Leu 
        35                  40                  45              


Ala Val Asn Arg Val Ile Pro Thr Asn Val Pro Glu Leu Thr Phe Gln 
    50                  55                  60                  


Pro Ser Pro Ala Pro Asp Pro Pro Gly Gly Leu Thr Tyr Phe Pro Val 
65                  70                  75                  80  


Ala Asp Leu Ser Ile Ile Ala Ala Leu Tyr Ala Arg Phe Thr Ala Gln 
                85                  90                  95      


Ile Arg Gly Ala Val Asp Leu Ser Leu Tyr Pro Arg Glu Gly Gly Val 
            100                 105                 110         


Ser Ser Arg Glu Leu Val Lys Lys Val Ser Asp Val Ile Trp Asn Ser 
        115                 120                 125             


Leu Ser Arg Ser Tyr Phe Lys Asp Arg Ala His Ile Gln Ser Leu Phe 
    130                 135                 140                 


Ser Phe Ile Thr Gly Thr Lys Leu Asp Ser Ser Gly Val Ala Phe Ala 
145                 150                 155                 160 


Val Val Gly Ala Cys Gln Ala Leu Gly Leu Arg Asp Val His Leu Ala 
                165                 170                 175     


Leu Ser Glu Asp His Ala Trp Val Val Phe Gly Pro Asn Gly Glu Gln 
            180                 185                 190         


Thr Ala Glu Val Thr Trp His Gly Lys Gly Asn Glu Asp Arg Arg Gly 
        195                 200                 205             


Gln Thr Val Asn Ala Gly Val Ala Glu Arg Ser Trp Leu Tyr Leu Lys 
    210                 215                 220                 


Gly Ser Tyr Met Arg Cys Asp Arg Lys Met Glu Val Ala Phe Met Val 
225                 230                 235                 240 


Cys Ala Ile Asn Pro Ser Ile Asp Leu His Thr Asp Ser Leu Glu Leu 
                245                 250                 255     


Leu Gln Leu Gln Gln Lys Leu Leu Trp Leu Leu Tyr Asp Leu Gly His 
            260                 265                 270         


Leu Glu Arg Tyr Pro Met Ala Leu Gly Asn Leu Ala Asp Leu Glu Glu 
        275                 280                 285             


Leu Glu Pro Thr Pro Gly Arg Pro Asp Pro Leu Thr Leu Tyr His Lys 
    290                 295                 300                 


Gly Ile Ala Ser Ala Lys Thr Tyr Tyr Arg Asp Glu His Ile Tyr Pro 
305                 310                 315                 320 


Tyr Met Tyr Leu Ala Gly Tyr His Cys Arg Asn Arg Asn Val Arg Glu 
                325                 330                 335     


Ala Leu Gln Ala Trp Ala Asp Thr Ala Thr Val Ile Gln Asp Tyr Asn 
            340                 345                 350         


Tyr Cys Arg Glu Asp Glu Glu Ile Tyr Lys Glu Phe Phe Glu Val Ala 
        355                 360                 365             


Asn Asp Val Ile Pro Asn Leu Leu Lys Glu Ala Ala Ser Leu Leu Glu 
    370                 375                 380                 


Ala Gly Glu Glu Arg Pro Gly Glu Gln Ser Gln Gly Thr Gln Ser Gln 
385                 390                 395                 400 


Gly Ser Ala Leu Gln Asp Pro Glu Cys Phe Ala His Leu Leu Arg Phe 
                405                 410                 415     


Tyr Asp Gly Ile Cys Lys Trp Glu Glu Gly Ser Pro Thr Pro Val Leu 
            420                 425                 430         


His Val Gly Trp Ala Thr Phe Leu Val Gln Ser Leu Gly Arg Phe Glu 
        435                 440                 445             


Gly Gln Val Arg Gln Lys Val Arg Ile Val Ser Arg Glu Ala Glu Ala 
    450                 455                 460                 


Ala Glu Ala Glu Glu Pro Trp Gly Glu Glu Ala Arg Glu Gly Arg Arg 
465                 470                 475                 480 


Arg Gly Pro Arg Arg Glu Ser Lys Pro Glu Glu Pro Pro Pro Pro Lys 
                485                 490                 495     


Lys Pro Ala Leu Asp Lys Gly Leu Gly Thr Gly Gln Gly Ala Val Ser 
            500                 505                 510         


Gly Pro Pro Arg Lys Pro Pro Gly Thr Val Ala Gly Thr Ala Arg Gly 
        515                 520                 525             


Pro Glu Gly Gly Ser Thr Ala Gln Val Pro Ala Pro Ala Ala Ser Pro 
    530                 535                 540                 


Pro Pro Glu Gly Pro Val Leu Thr Phe Gln Ser Glu Lys Met Lys Gly 
545                 550                 555                 560 


Met Lys Glu Leu Leu Val Ala Thr Lys Ile Asn Ser Ser Ala Ile Lys 
                565                 570                 575     


Leu Gln Leu Thr Ala Gln Ser Gln Val Gln Met Lys Lys Gln Lys Val 
            580                 585                 590         


Ser Thr Pro Ser Asp Tyr Thr Leu Ser Phe Leu Lys Arg Gln Arg Lys 
        595                 600                 605             


Gly Leu His His His His His His 
    610                 615     



