                         SEQUENCE LISTING

<110>  ͯϺҽе޹˾
 
<120>  ת״ص׽ԼƱμеӦ

<130>  P20406281CF

<150>  201911302937.3
<151>  2019-12-17

<150>  202010506950.7
<151>  2020-06-05

<150>  202010976582.2
<151>  2020-09-16

<150>  202010974997.6
<151>  2020-09-16

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  2
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TTRƬŻĺ

<400>  2
ggtccgaccg gtaccggtga atctaaatgc ccgctgatgg ttaaagttct ggacgctgtt       60

cgtggttctc cggctatcaa cgttgctgtt cacgttttcc gtaaagctgc tgacgacacc      120

tgggaaccgt tcgcttctgg taaaacctct gaatctggtg aactgcacgg tctgaccacc      180

gaagaagaat tcgttgaagg tatctacaaa gttgaaatcg acaccaaatc ttactggaaa      240

gctctgggta tctctccgtt ccacgaacac gctgaagttg ttttcaccgc taacgactct      300

ggtccgcgtc gttacaccat cgctgctctg ctgtctccgt actcttactc taccaccgct      360

gttgttacca acccgaaaga a                                                381


<210>  3
<211>  4693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  

<400>  3
aattcttaag aaggagatat acatatgaga ggatcgcatc atcatcatca tcatggatcc       60

ggtccgaccg gtaccggtga atctaaatgc ccgctgatgg ttaaagttct ggacgctgtt      120

cgtggttctc cggctatcaa cgttgctgtt cacgttttcc gtaaagctgc tgacgacacc      180

tgggaaccgt tcgcttctgg taaaacctct gaatctggtg aactgcacgg tctgaccacc      240

gaagaagaat tcgttgaagg tatctacaaa gttgaaatcg acaccaaatc ttactggaaa      300

gctctgggta tctctccgtt ccacgaacac gctgaagttg ttttcaccgc taacgactct      360

ggtccgcgtc gttacaccat cgctgctctg ctgtctccgt actcttactc taccaccgct      420

gttgttacca acccgaaaga atgaaagctt ctgttttggc ggatgagaga agattttcag      480

cctgatacag attaaatcag aacgcagaag cggtctgata aaacagaatt tgcctggcgg      540

cagtagcgcg gtggtcccac ctgaccccat gccgaactca gaagtgaaac gccgtagcgc      600

cgatggtagt gtggggtctc cccatgcgag agtagggaac tgccaggcat caaataaaac      660

gaaaggctca gtcgaaagac tgggcctttc gttttatctg ttgtttgtcg gtgaacgctc      720

tcctgagtag gacaaatccg ccgggagcgg atttgaacgt tgcgaagcaa cggcccggag      780

ggtggcgggc aggacgcccg ccataaactg ccaggcatca aattaagcag aaggccatcc      840

tgacggatgg cctttttgcg tttctacaaa ctcttttgtt tatttttcta aatacattca      900

aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg      960

aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc     1020

cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg     1080

ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt     1140

cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta     1200

ttatcccgtg ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat     1260

gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga     1320

gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca     1380

acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact     1440

cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc     1500

acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact     1560

ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt     1620

ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt     1680

gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt     1740

atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata     1800

ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag     1860

attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat     1920

ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa     1980

aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca     2040

aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt     2100

ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg     2160

tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc     2220

ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga     2280

cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc     2340

agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc     2400

gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca     2460

ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg     2520

tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta     2580

tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct     2640

cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag     2700

tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa     2760

gcggaagagc gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc     2820

atatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagtatacac     2880

tccgctatcg ctacgtgact gggtcatggc tgcgccccga cacccgccaa cacccgctga     2940

cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc     3000

cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga ggcagctgcg     3060

gtaaagctca tcagcgtggt cgtgaagcga ttcacagatg tctgcctgtt catccgcgtc     3120

cagctcgttg agtttctcca gaagcgttaa tgtctggctt ctgataaagc gggccatgtt     3180

aagggcggtt ttttcctgtt tggtcacttg atgcctccgt gtaaggggga atttctgttc     3240

atgggggtaa tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat     3300

gaacatgccc ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg     3360

gaccagagaa aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt     3420

ccacagggta gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct     3480

gacttccgcg tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct     3540

caggtcgcag acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca     3600

ttctgctaac cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg     3660

atcatgcgca cccgtggcca ggacccaacg ctgcccgaga tgcgccgcgt gcggctgctg     3720

gagatggcgg acgcgatgga tatgttctgc caagggttgg tttgcgcatt cacagttctc     3780

cgcaagaatt gattggctcc aattcttgga gtggtgaatc cgttagcgag gtgccgccgg     3840

cttccattca ggtcgaggtg gcccggctcc atgcaccgcg acgcaacgcg gggaggcaga     3900

caaggtatag ggcggcgcct acaatccatg ccaacccgtt ccatgtgctc gccgaggcgg     3960

cataaatcgc cgtgacgatc agcggtccag tgatcgaagt taggctggta agagccgcga     4020

gcgatccttg aagctgtccc tgatggtcgt catctacctg cctggacagc atggcctgca     4080

acgcgggcat cccgatgccg ccggaagcga gaagaatcat aatggggaag gccatccagc     4140

ctcgcgtcgc gaacgccagc aagacgtagc ccagcgcgtc ggccgccatg ccggcgataa     4200

tggcctgctt ctcgccgaaa cgtttggtgg cgggaccagt gacgaaggct tgagcgaggg     4260

cgtgcaagat tccgaatacc gcaagcgaca ggccgatcat cgtcgcgctc cagcgaaagc     4320

ggtcctcgcc gaaaatgacc cagagcgctg ccggcacctg tcctacgagt tgcatgataa     4380

agaagacagt cataagtgcg gcgacgatag tcatgccccg cgcccaccgg aaggagctga     4440

ctgggttgaa ggctctcaag ggcatcggtc gacgctctcc cttatgcgac tcctgcatta     4500

ggaagcagcc cagtagtagg ttgaggccgt tgagcaccgc cgccgcaagg aatggtgcat     4560

gcatcgatca ccacaattca gcaaattgtg aacatcatca cgttcatctt tccctggttg     4620

ccaatggccc attttcctgt cagtaacgag aaggtcgcga attcaggcgc tttttagact     4680

ggtcgtaatg aac                                                        4693


<210>  4
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tag-TTR

<400>  4
atgagaggat cgcatcatca tcatcatcat ggatccggtc cgaccggtac cggtgaatct       60

aaatgcccgc tgatggttaa agttctggac gctgttcgtg gttctccggc tatcaacgtt      120

gctgttcacg ttttccgtaa agctgctgac gacacctggg aaccgttcgc ttctggtaaa      180

acctctgaat ctggtgaact gcacggtctg accaccgaag aagaattcgt tgaaggtatc      240

tacaaagttg aaatcgacac caaatcttac tggaaagctc tgggtatctc tccgttccac      300

gaacacgctg aagttgtttt caccgctaac gactctggtc cgcgtcgtta caccatcgct      360

gctctgctgt ctccgtactc ttactctacc accgctgttg ttaccaaccc gaaagaatga      420


<210>  5
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tag-TTR-GFP

<400>  5
atgcgtggtt ctcaccacca ccaccaccac ggttctggtc cgaccggtac cggtgaatct       60

aaatgcccgc tgatggttaa agttctggac gctgttcgtg gttctccggc tatcaacgtt      120

gctgttcacg ttttccgtaa agctgctgac gacacctggg aaccgttcgc ttctggtaaa      180

acctctgaat ctggtgaact gcacggtctg accaccgaag aagaatttgt tgaaggtatc      240

tacaaagttg aaatcgacac caaatcttac tggaaagctc tgggtatctc tccgttccac      300

gaacacgctg aagttgtttt caccgctaac gactctggtc cgcgtcgtta caccatcgct      360

gctctgctgt ctccgtactc ttactctacc accgctgttg ttaccaaccc gaaagaaggt      420

tctatgtcta aaggtgaaga actgttcacc ggtgttgttc cgatcctggt tgaactggac      480

ggtgacgtta acggtcacaa attctctgtt tctggtgaag gtgaaggtga cgctacctac      540

ggtaaactga ccctgaaatt catctgcacc accggtaaac tgccggttcc gtggccgacc      600

ctggttacca ccttcaccta cggtgttcag tgcttctctc gttacccgga ccacatgaaa      660

cagcacgact tcttcaaatc tgctatgccg gaaggttacg ttcaggaacg taccatcttc      720

ttcaaagacg acggtaacta caaaacccgt gctgaagtta aattcgaagg tgacaccctg      780

gttaaccgta tcgaactgaa aggtatcgac ttcaaagaag acggtaacat cctgggtcac      840

aaactggaat acaactacaa ctctcacaac gtttacatca tggctgacaa acagaaaaac      900

ggtatcaaag ttaacttcaa aatccgtcac aacatcgaag acggttctgt tcagctggct      960

gaccactacc agcagaacac cccgatcggt gacggtccgg ttctgctgcc ggacaaccac     1020

tacctgtcta cccagtctgc tctgtctaaa gacccgaacg aaaaacgtga ccacatggtt     1080

ctgctggaat ttgttaccgc tgctggtatc acccacggta tggacgaact gtacaaa        1137


<210>  6
<211>  864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tag-TTR-Lysozyme

<400>  6
atgcgtggtt ctcaccacca ccaccaccac ggttctggtc cgaccggtac cggtgaatct       60

aaatgcccgc tgatggttaa agttctggac gctgttcgtg gttctccggc tatcaacgtt      120

gctgttcacg ttttccgtaa agctgctgac gacacctggg aaccgttcgc ttctggtaaa      180

acctctgaat ctggtgaact gcacggtctg accaccgaag aagaatttgt tgaaggtatc      240

tacaaagttg aaatcgacac caaatcttac tggaaagctc tgggtatctc tccgttccac      300

gaacacgctg aagttgtttt caccgctaac gactctggtc cgcgtcgtta caccatcgct      360

gctctgctgt ctccgtactc ttactctacc accgctgttg ttaccaaccc gaaagaaggt      420

tctatgcgtt ctctgctgat cctggttctg tgcttcctgc cgctggctgc tctgggtaaa      480

gttttcggtc gttgcgaact ggctgctgct atgaaacgtc acggtctgga caactaccgt      540

ggttactctc tgggtaactg ggtttgcgct gctaaattcg aatctaactt caacacccag      600

gctaccaacc gtaacaccga cggttctacc gactacggta tcctgcagat caactctcgt      660

tggtggtgca acgacggtcg taccccgggt tctcgtaacc tgtgcaacat cccgtgctct      720

gctctgctgt cttctgacat caccgcttct gttaactgcg ctaaaaaaat cgtttctgac      780

ggtaacggta tgaacgcttg ggttgcttgg cgtaaccgtt gcaaaggtac cgacgttcag      840

gcttggatcc gtggttgccg tctg                                             864


<210>  7
<211>  1581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-tag-TTR-Ovalbumin

<400>  7
atgcgtggtt ctcaccacca ccaccaccac ggttctggtc cgaccggtac cggtgaatct       60

aaatgcccgc tgatggttaa agttctggac gctgttcgtg gttctccggc tatcaacgtt      120

gctgttcacg ttttccgtaa agctgctgac gacacctggg aaccgttcgc ttctggtaaa      180

acctctgaat ctggtgaact gcacggtctg accaccgaag aagaatttgt tgaaggtatc      240

tacaaagttg aaatcgacac caaatcttac tggaaagctc tgggtatctc tccgttccac      300

gaacacgctg aagttgtttt caccgctaac gactctggtc cgcgtcgtta caccatcgct      360

gctctgctgt ctccgtactc ttactctacc accgctgttg ttaccaaccc gaaagaaggt      420

tctatgggtt ctatcggtgc tgcttctatg gaattttgct tcgacgtttt caaagaactg      480

aaagttcacc acgctaacga aaacatcttc tactgcccga tcgctatcat gtctgctctg      540

gctatggttt acctgggtgc taaagactct acccgtaccc agatcaacaa agttgttcgt      600

ttcgacaaac tgccgggttt cggtgactct atcgaagctc agtgcggtac ctctgttaac      660

gttcactctt ctctgcgtga catcctgaac cagatcacca aaccgaacga cgtttactct      720

ttctctctgg cttctcgtct gtacgctgaa gaacgttacc cgatcctgcc ggaatacctg      780

cagtgcgtta aagaactgta ccgtggtggt ctggaaccga tcaacttcca gaccgctgct      840

gaccaggctc gtgaactgat caactcttgg gttgaatctc agaccaacgg tatcatccgt      900

aacgttctgc agccgtcttc tgttgactct cagaccgcta tggttctggt taacgctatc      960

gttttcaaag gtctgtggga aaaagctttc aaagacgaag acacccaggc tatgccgttc     1020

cgtgttaccg aacaggaatc taaaccggtt cagatgatgt accagatcgg tctgttccgt     1080

gttgcttcta tggcttctga aaaaatgaaa atcctggaac tgccgttcgc ttctggtacc     1140

atgtctatgc tggttctgct gccggacgaa gtttctggtc tggaacagct ggaatctatc     1200

atcaacttcg aaaaactgac cgaatggacc tcttctaacg ttatggaaga acgtaaaatc     1260

aaagtttacc tgccgcgtat gaaaatggaa gaaaaataca acctgacctc tgttctgatg     1320

gctatgggta tcaccgacgt tttctcttct tctgctaacc tgtctggtat ctcttctgct     1380

gaatctctga aaatctctca ggctgttcac gctgctcacg ctgaaatcaa cgaagctggt     1440

cgtgaagttg ttggttctgc tgaagctggt gttgacgctg cttctgtttc tgaagaattt     1500

cgtgctgacc acccgttcct gttctgcatc aaacacatcg ctaccaacgc tgttctgttc     1560

ttcggtcgtt gcgtttctcc g                                               1581


<210>  8
<211>  4311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pET-21aع

<400>  8
aattcttaag aaggagatat acatatggga tcccatcatc atcatcatca ttgactgcag       60

ccaagcttct gttttggcgg atgagagaag attttcagcc tgatacagat taaatcagaa      120

cgcagaagcg gtctgataaa acagaatttg cctggcggca gtagcgcggt ggtcccacct      180

gaccccatgc cgaactcaga agtgaaacgc cgtagcgccg atggtagtgt ggggtctccc      240

catgcgagag tagggaactg ccaggcatca aataaaacga aaggctcagt cgaaagactg      300

ggcctttcgt tttatctgtt gtttgtcggt gaacgctctc ctgagtagga caaatccgcc      360

gggagcggat ttgaacgttg cgaagcaacg gcccggaggg tggcgggcag gacgcccgcc      420

ataaactgcc aggcatcaaa ttaagcagaa ggccatcctg acggatggcc tttttgcgtt      480

tctacaaact cttttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac      540

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt      600

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag      660

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg      720

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa      780

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtgtt gacgccgggc      840

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag      900

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa      960

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     1020

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     1080

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     1140

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     1200

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     1260

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag     1320

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     1380

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     1440

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     1500

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     1560

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     1620

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     1680

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     1740

gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga     1800

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     1860

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     1920

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     1980

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa     2040

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     2100

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     2160

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     2220

cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat     2280

cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca     2340

gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ctgatgcggt     2400

attttctcct tacgcatctg tgcggtattt cacaccgcat atatggtgca ctctcagtac     2460

aatctgctct gatgccgcat agttaagcca gtatacactc cgctatcgct acgtgactgg     2520

gtcatggctg cgccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg     2580

ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg     2640

ttttcaccgt catcaccgaa acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg     2700

tgaagcgatt cacagatgtc tgcctgttca tccgcgtcca gctcgttgag tttctccaga     2760

agcgttaatg tctggcttct gataaagcgg gccatgttaa gggcggtttt ttcctgtttg     2820

gtcacttgat gcctccgtgt aagggggaat ttctgttcat gggggtaatg ataccgatga     2880

aacgagagag gatgctcacg atacgggtta ctgatgatga acatgcccgg ttactggaac     2940

gttgtgaggg taaacaactg gcggtatgga tgcggcggga ccagagaaaa atcactcagg     3000

gtcaatgcca gcgcttcgtt aatacagatg taggtgttcc acagggtagc cagcagcatc     3060

ctgcgatgca gatccggaac ataatggtgc agggcgctga cttccgcgtt tccagacttt     3120

acgaaacacg gaaaccgaag accattcatg ttgttgctca ggtcgcagac gttttgcagc     3180

agcagtcgct tcacgttcgc tcgcgtatcg gtgattcatt ctgctaacca gtaaggcaac     3240

cccgccagcc tagccgggtc ctcaacgaca ggagcacgat catgcgcacc cgtggccagg     3300

acccaacgct gcccgagatg cgccgcgtgc ggctgctgga gatggcggac gcgatggata     3360

tgttctgcca agggttggtt tgcgcattca cagttctccg caagaattga ttggctccaa     3420

ttcttggagt ggtgaatccg ttagcgaggt gccgccggct tccattcagg tcgaggtggc     3480

ccggctccat gcaccgcgac gcaacgcggg gaggcagaca aggtataggg cggcgcctac     3540

aatccatgcc aacccgttcc atgtgctcgc cgaggcggca taaatcgccg tgacgatcag     3600

cggtccagtg atcgaagtta ggctggtaag agccgcgagc gatccttgaa gctgtccctg     3660

atggtcgtca tctacctgcc tggacagcat ggcctgcaac gcgggcatcc cgatgccgcc     3720

ggaagcgaga agaatcataa tggggaaggc catccagcct cgcgtcgcga acgccagcaa     3780

gacgtagccc agcgcgtcgg ccgccatgcc ggcgataatg gcctgcttct cgccgaaacg     3840

tttggtggcg ggaccagtga cgaaggcttg agcgagggcg tgcaagattc cgaataccgc     3900

aagcgacagg ccgatcatcg tcgcgctcca gcgaaagcgg tcctcgccga aaatgaccca     3960

gagcgctgcc ggcacctgtc ctacgagttg catgataaag aagacagtca taagtgcggc     4020

gacgatagtc atgccccgcg cccaccggaa ggagctgact gggttgaagg ctctcaaggg     4080

catcggtcga cgctctccct tatgcgactc ctgcattagg aagcagccca gtagtaggtt     4140

gaggccgttg agcaccgccg ccgcaaggaa tggtgcatgc atcgatcacc acaattcagc     4200

aaattgtgaa catcatcacg ttcatctttc cctggttgcc aatggcccat tttcctgtca     4260

gtaacgagaa ggtcgcgaat tcaggcgctt tttagactgg tcgtaatgaa c              4311


<210>  9
<211>  127
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Gly Pro Gly Gly Ala Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Val Asp Val Ala Val Lys Val 
            20                  25                  30          


Phe Lys Lys Thr Ala Asp Gly Ser Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ala Glu Ser Gly Glu Leu His Gly Leu Thr Thr Asp Glu Lys Phe 
    50                  55                  60                  


Thr Glu Gly Val Tyr Arg Val Glu Leu Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu Tyr Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly His Arg His Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Ser Asn Pro Gln Asn 
        115                 120                 125         


<210>  10
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  10

Gly Pro Ala Gly Ala Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Val Asp Val Ala Val Lys Val 
            20                  25                  30          


Phe Lys Lys Thr Ser Glu Gly Ser Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ala Glu Ser Gly Glu Leu His Gly Leu Thr Thr Asp Glu Lys Phe 
    50                  55                  60                  


Val Glu Gly Val Tyr Arg Val Glu Leu Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Thr Leu Gly Ile Ser Pro Phe His Glu Phe Ala Asp Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly His Arg His Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Ser Asn Pro Gln Asn 
        115                 120                 125         


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ԴTTR-CL

<400>  11

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Glu Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val 
        115                 120         


