﻿                         序列表

<110>  四川大学华西医院

<120>  同时靶向间皮素和FAP的双靶点嵌合抗原受体及其用途

<130>  G20P0008K

<141>  2020-05-27

<150>  201911291969.8
<151>  2019-12-16

<160>  36

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  568
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Ala Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu 
            20                  25                  30          
Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr 
        35                  40                  45              
Thr Phe Thr Glu Asn Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln 
    50                  55                  60                  
Gly Leu Glu Trp Ile Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys 
65                  70                  75                  80  
Tyr Asn Glu Lys Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      
Ser Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         
Val Tyr Phe Cys Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Leu Met Thr 
145                 150                 155                 160 
Gln Ser Pro Ala Ser Ser Val Val Ser Leu Ser Gly Gln Arg Ala Thr 
                165                 170                 175     
Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr 
            180                 185                 190         
Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        195                 200                 205             
Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly 
    210                 215                 220                 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu 
225                 230                 235                 240 
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Tyr 
                245                 250                 255     
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Asp Pro Ala Glu Pro 
            260                 265                 270         
Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
        275                 280                 285             
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 
Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     
Leu Ser Pro Gly Lys Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            500                 505                 510         
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
        515                 520                 525             
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    530                 535                 540                 
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
545                 550                 555                 560 
Glu Glu Glu Gly Gly Cys Glu Leu 
                565             

<210>  2
<211>  1707
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  2
atggagacag atacactgct gctgtgggtg ctgctgctgt gggtgcccgg cagcaccggc        60
gctcaagtgc agctgaaaca gtccggcgcc gaactggtga aacccggcgc cagcgtgaag       120
ctgagctgca agaccagcgg atacaccttc accgagaaca tcatccactg ggtgaagcag       180
aggagcggcc aaggcctcga gtggattgga tggttccatc ccggcagcgg cagcatcaag       240
tacaatgaga agaaagacaa ggccacactg accgctgaca agagctcctc caccgtgtat       300
atggagctgt ctagactgac aagcgaggac agcgccgtgt acttctgcgc tagacatgga       360
ggcaccggaa gaggagccat ggactattgg ggccaaggca caagcgtcac agtgtcctcc       420
ggcggaggag gcagcggagg aggcggaagc ggcggcggag gcagcgacat tctgatgacc       480
caatcccccg cctccagcgt ggtgtccctc tccggacaga gagctaccat cagctgtaga       540
gctagcaagt ccgtgagcac atccgcctac agctacatgc actggtacca gcagaaaccc       600
ggacaacctc ccaagctgct gatctatctg gccagcaatc tcgagagcgg cgtgcctcct       660
agattttccg gctccggcag cggcacagac ttcaccctca acatccatcc cgtggaggaa       720
gaggatgccg ccacatacta ctgccagcat tctagagagc tgccctacac ctttggaggc       780
ggcaccaaac tggagatcaa agatcccgcc gagcctaaga gccccgacaa gacccacaca       840
tgtcctcctt gtcccgcccc tcccgtggct ggacctagcg tgtttctgtt cccccccaag       900
cccaaggaca cactgatgat cgctagaaca cccgaggtga catgcgtcgt ggtggacgtc       960
tcccacgaag accccgaggt gaagttcaac tggtacgtgg acggagtgga agtccacaac      1020
gccaaaacaa agcctagaga ggagcagtac aactccacat atagagtggt gtccgtgctg      1080
acagtgctcc accaagactg gctgaacggc aaggagtaca agtgcaaggt cagcaacaag      1140
gctctgcccg cccctattga gaagaccatc agcaaggcca agggccagcc tagagaaccc      1200
caagtctata ccctccctcc ctctagagac gagctcacca agaatcaagt gtctctgaca      1260
tgtctggtca agggctttta ccctagcgac attgctgtgg agtgggagtc caacggccag      1320
cccgagaaca actacaagac cacacccccc gtgctggata gcgacggcag cttctttctg      1380
tattccaagc tgaccgtgga taagagcaga tggcagcaag gcaacgtgtt tagctgtagc      1440
gtcatgcacg aggctctgca caaccactat acccagaagt ctctgtctct gtcccccggc      1500
aagaagatct acatctgggc tcctctggct ggaacatgcg gcgtgctgct gctgtctctg      1560
gtcatcacac tgtactgtaa gaggggcaga aagaagctgc tctacatctt caagcagccc      1620
ttcatgagac ccgtccagac aacccaagag gaggacggat gcagctgcag atttcccgaa      1680
gaggaggagg gaggatgcga gctctga                                          1707

<210>  3
<211>  527
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
            20                  25                  30          
Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
        35                  40                  45              
Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  
Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
65                  70                  75                  80  
Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro 
                85                  90                  95      
Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
            100                 105                 110         
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr 
        115                 120                 125             
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 
Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala 
                165                 170                 175     
Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile 
            180                 185                 190         
Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser 
        195                 200                 205             
Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln 
    210                 215                 220                 
Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala 
225                 230                 235                 240 
Asn Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
                245                 250                 255     
Asp Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly 
            260                 265                 270         
Gly Thr Gln Leu Thr Val Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 
Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                325                 330                 335     
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            340                 345                 350         
Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        355                 360                 365             
Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    370                 375                 380                 
Arg Asp Phe Ala Ala Tyr Arg Ser Val Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 
Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        435                 440                 445             
Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    450                 455                 460                 
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
465                 470                 475                 480 
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                485                 490                 495     
Tyr Arg His Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe 
            500                 505                 510         
Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        515                 520                 525         

<210>  4
<211>  1504
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
atggctttac ccgttaccgc tctcttatta cctctggctc tgctgctgca tgccgccaga        60
cccgcagcag agcggacccg gtttagtgac ccctagccag actttaagcc tcacatgcgc       120
catttccggc gacagcgtca gcagcaacag cgccacttgg aactggattc gtcaatcccc       180
ctctcgtggt ttagaatggc tgggaaggac ctactatcgt agcaagtggt acaacgacta       240
cgctgtgagc gtgaagtctc gtatgtccat caaccccgac acaagcaaga accagttctc       300
tttacagctc aactccgtca cacccgaaga caccgctgtc tactattgcg ctcgtggcat       360
gatgacatac tattacggca tggacgtgtg gggacaaggc actaccgtga cagtgtcctc       420
cggcatcctc ggttccggcg gcggcggcag cggcggcgga ggctccggcg gtggcggcag       480
ccaacccgtt ctgacacaga gcagcagcct cagcgcttcc cccggagctt ccgcttcttt       540
aacttgtaca ttacgtagcg gaattaacgt gggcccctac agaatctact ggtatcaaca       600
gaagcccgga agcccccccc agtatttact caactacaag agcgactccg acaaacagca       660
aggtagcggc gtgccctctc gtttttccgg ctccaaggat gcctccgcca atgccggcgt       720
gctgctgatt agcggtttaa ggtccgagga tgaggctgat tactactgta tgatttggca       780
tagcagcgcc gccgtgtttg gcggcggaac acagctgacc gtgctgacca caacacccgc       840
tcccagacct cctacccccg ctcctaccat cgccagccag cctctgtctt taagacccga       900
ggcttgtaga cccgctgctg gcggagctgt gcacaccaga ggtttagact ttgcttgtga       960
tttctgggtg ctcgtggtcg tgggaggcgt tttagcttgc tacagcttat tagtgaccgt      1020
ggcctttatc attttctggg tgaggtccaa aagatctcgt ctgctgcact ccgactacat      1080
gaatatgaca cctaggaggc ccggtcccac tcgtaagcac taccagcctt acgccccccc      1140
cagagacttc gccgcttatc gttccgtgag agtgaagttt tctcgttccg ccgatgctcc      1200
cgcttaccag caaggtcaga accagctgta caacgaatta aatctgggtc gtagagagga      1260
gtacgacgtt ttagataaga ggaggggcag agatcccgaa atgggcggca agcccagaag      1320
gaaaaaccct caagagggcc tctacaatga gctgcagaag gacaagatgg ccgaggctta      1380
ttccgaaatc ggcatgaaag gcgagagaag aaggggcaag ggacatgatg gtttatacca      1440
aggtttaagc acagccacca aagacaccta cgacgcctac agacatcaag ctctcccccc      1500
caga                                                                   1504

<210>  5
<211>  22
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
1               5                   10                  15      
Glu Glu Asn Pro Gly Pro 
            20          

<210>  6
<211>  66
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  6
agcggcagcg gcgagggaag aggaagcctg ctgacctgcg gcgatgtgga ggagaatccc        60
ggcccc                                                                   66

<210>  7
<211>  4
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Arg Arg Lys Arg 
1               

<210>  8
<211>  12
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  8
aggaggaaga ga                                                            12

<210>  9
<211>  21
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro 
            20      

<210>  10
<211>  63
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
atggctttac ccgttaccgc tctcttatta cctctggctc tgctgctgca tgccgccaga        60
ccc                                                                      63

<210>  11
<211>  258
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          
Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              
Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  
Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  
Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ile Leu Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 
Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser 
145                 150                 155                 160 
Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr 
                165                 170                 175     
Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu 
            180                 185                 190         
Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro 
        195                 200                 205             
Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu 
    210                 215                 220                 
Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met 
225                 230                 235                 240 
Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr 
                245                 250                 255     
Val Leu 
        

<210>  12
<211>  774
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  12
caagttcaac tgcagcagag cggacccggt ttagtgaccc ctagccagac tttaagcctc        60
acatgcgcca tttccggcga cagcgtcagc agcaacagcg ccacttggaa ctggattcgt       120
caatccccct ctcgtggttt agaatggctg ggaaggacct actatcgtag caagtggtac       180
aacgactacg ctgtgagcgt gaagtctcgt atgtccatca accccgacac aagcaagaac       240
cagttctctt tacagctcaa ctccgtcaca cccgaagaca ccgctgtcta ctattgcgct       300
cgtggcatga tgacatacta ttacggcatg gacgtgtggg gacaaggcac taccgtgaca       360
gtgtcctccg gcatcctcgg ttccggcggc ggcggcagcg gcggcggagg ctccggcggt       420
ggcggcagcc aacccgttct gacacagagc agcagcctca gcgcttcccc cggagcttcc       480
gcttctttaa cttgtacatt acgtagcgga attaacgtgg gcccctacag aatctactgg       540
tatcaacaga agcccggaag ccccccccag tatttactca actacaagag cgactccgac       600
aaacagcaag gtagcggcgt gccctctcgt ttttccggct ccaaggatgc ctccgccaat       660
gccggcgtgc tgctgattag cggtttaagg tccgaggatg aggctgatta ctactgtatg       720
atttggcata gcagcgccgc cgtgtttggc ggcggaacac agctgaccgt gctg             774

<210>  13
<211>  45
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  

<210>  14
<211>  135
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  14
accacaacac ccgctcccag acctcctacc cccgctccta ccatcgccag ccagcctctg        60
tctttaagac ccgaggcttg tagacccgct gctggcggag ctgtgcacac cagaggttta       120
gactttgctt gtgat                                                        135

<210>  15
<211>  68
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          
Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              
Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  
Ala Tyr Arg Ser 
65              

<210>  16
<211>  204
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  16
ttctgggtgc tcgtggtcgt gggaggcgtt ttagcttgct acagcttatt agtgaccgtg        60
gcctttatca ttttctgggt gaggtccaaa agatctcgtc tgctgcactc cgactacatg       120
aatatgacac ctaggaggcc cggtcccact cgtaagcact accagcctta cgcccccccc       180
agagacttcg ccgcttatcg ttcc                                              204

<210>  17
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Tyr Arg His Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210>  18
<211>  339
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  18
gtgagagtga agttttctcg ttccgccgat gctcccgctt accagcaagg tcagaaccag        60
ctgtacaacg aattaaatct gggtcgtaga gaggagtacg acgttttaga taagaggagg       120
ggcagagatc ccgaaatggg cggcaagccc agaaggaaaa accctcaaga gggcctctac       180
aatgagctgc agaaggacaa gatggccgag gcttattccg aaatcggcat gaaaggcgag       240
agaagaaggg gcaagggaca tgatggttta taccaaggtt taagcacagc caccaaagac       300
acctacgacg cctacagaca tcaagctctc ccccccaga                              339

<210>  19
<211>  26
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  19
Arg Arg Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      

<210>  20
<211>  78
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  20
agcggcagcg gcgagggaag aggaagcctg ctgacctgcg gcgatgtgga ggagaatccc        60
ggccccagga ggaagaga                                                      78

<210>  21
<211>  21
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Ala 
            20      

<210>  22
<211>  63
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  22
atggagacag atacactgct gctgtgggtg ctgctgctgt gggtgcccgg cagcaccggc        60
gct                                                                      63

<210>  23
<211>  246
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  23
Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          
Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Lys 
    50                  55                  60                  
Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met 
65                  70                  75                  80  
Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95      
Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ala Ser 
    130                 135                 140                 
Ser Val Val Ser Leu Ser Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 
Ser Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn 
            180                 185                 190         
Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr 
    210                 215                 220                 
Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Ile Lys 
                245     

<210>  24
<211>  738
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  24
caagtgcagc tgaaacagtc cggcgccgaa ctggtgaaac ccggcgccag cgtgaagctg        60
agctgcaaga ccagcggata caccttcacc gagaacatca tccactgggt gaagcagagg       120
agcggccaag gcctcgagtg gattggatgg ttccatcccg gcagcggcag catcaagtac       180
aatgagaaga aagacaaggc cacactgacc gctgacaaga gctcctccac cgtgtatatg       240
gagctgtcta gactgacaag cgaggacagc gccgtgtact tctgcgctag acatggaggc       300
accggaagag gagccatgga ctattggggc caaggcacaa gcgtcacagt gtcctccggc       360
ggaggaggca gcggaggagg cggaagcggc ggcggaggca gcgacattct gatgacccaa       420
tcccccgcct ccagcgtggt gtccctctcc ggacagagag ctaccatcag ctgtagagct       480
agcaagtccg tgagcacatc cgcctacagc tacatgcact ggtaccagca gaaacccgga       540
caacctccca agctgctgat ctatctggcc agcaatctcg agagcggcgt gcctcctaga       600
ttttccggct ccggcagcgg cacagacttc accctcaaca tccatcccgt ggaggaagag       660
gatgccgcca catactactg ccagcattct agagagctgc cctacacctt tggaggcggc       720
accaaactgg agatcaaa                                                     738

<210>  25
<211>  235
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  25
Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      
Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          
Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys 
225                 230                 235 

<210>  26
<211>  705
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  26
gatcccgccg agcctaagag ccccgacaag acccacacat gtcctccttg tcccgcccct        60
cccgtggctg gacctagcgt gtttctgttc ccccccaagc ccaaggacac actgatgatc       120
gctagaacac ccgaggtgac atgcgtcgtg gtggacgtct cccacgaaga ccccgaggtg       180
aagttcaact ggtacgtgga cggagtggaa gtccacaacg ccaaaacaaa gcctagagag       240
gagcagtaca actccacata tagagtggtg tccgtgctga cagtgctcca ccaagactgg       300
ctgaacggca aggagtacaa gtgcaaggtc agcaacaagg ctctgcccgc ccctattgag       360
aagaccatca gcaaggccaa gggccagcct agagaacccc aagtctatac cctccctccc       420
tctagagacg agctcaccaa gaatcaagtg tctctgacat gtctggtcaa gggcttttac       480
cctagcgaca ttgctgtgga gtgggagtcc aacggccagc ccgagaacaa ctacaagacc       540
acaccccccg tgctggatag cgacggcagc ttctttctgt attccaagct gaccgtggat       600
aagagcagat ggcagcaagg caacgtgttt agctgtagcg tcatgcacga ggctctgcac       660
aaccactata cccagaagtc tctgtctctg tcccccggca agaag                       705

<210>  27
<211>  24
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  27
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  

<210>  28
<211>  72
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  28
atctacatct gggctcctct ggctggaaca tgcggcgtgc tgctgctgtc tctggtcatc        60
acactgtact gt                                                            72

<210>  29
<211>  42
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  29
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210>  30
<211>  126
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  30
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa        60
actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt       120
gaactg                                                                  126

<210>  31
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  31
aggtttaaac tacggatggc tttacccgtt accgctc                                 37

<210>  32
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  32
atgactagtc ccgggtcatc tgggggggag agcttga                                 37

<210>  33
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  33
aggtttaaac tacggatgga gacagataca ctgctgc                                 37

<210>  34
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  34
atgactagtc ccgggtcaca gttcacatcc tccttct                                 37

<210>  35
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  35
aggtttaaac tacggatggc tttacccgtt accgctc                                 37

<210>  36
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  36
atgactagtc ccgggtcaca gttcacatcc tccttct                                 37

