                         SEQUENCE LISTING

<110>  ϺĿҽҩƼ޹˾
 
<120>  һַ±øͻ弰Ӧ

<130>  P19405293C

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  304
<212>  PRT
<213>  Rhodopseudomonas palustris

<400>  1

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Trp Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  2
<211>  912
<212>  DNA
<213>  Rhodopseudomonas palustris

<400>  2
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accactggtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  3
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H155W156-


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)
<223>  k is g or t

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (21)
<223>  k is g or t

<400>  3
gcactgaaaa tctatnnknn kagctttctg gcacagc                                37


<210>  4
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H155W156-


<220>
<221>  misc_feature
<222>  (17)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (20)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is a, c, g, or t

<400>  4
gctgtgccag aaagctmnnm nnatagattt tcagtgc                                37


<210>  5
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y219-


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)
<223>  k is g or t

<400>  5
gtgatgtgtg aagatnnkcg tgcgggtgcg tatg                                   34


<210>  6
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y219-


<220>
<221>  misc_feature
<222>  (17)
<223>  m is a or c

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  6
catacgcacc cgcacgmnna tcttcacaca tcac                                   34


<210>  7
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ1(H155IW156SY219F)

<400>  7

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ile Ser Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Phe Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  8
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ1(H155IW156SY219F)

<400>  8
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acatctcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agacttccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  9
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ2(H155VW156MY219L)

<400>  9

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Met Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Leu Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  10
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ2(H155VW156MY219L)

<400>  10
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttatgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agacctgcgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  11
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ3(H155VW156RY219M)

<400>  11

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Arg Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Met Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  12
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ3(H155VW156RY219M)

<400>  12
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttcgttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agacatgcgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  13
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ4(H155IW156S)

<400>  13

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ile Ser Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  14
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ4(H155IW156S)

<400>  14
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acatctcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  15
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ5(H155NW156F)

<400>  15

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Asn Phe Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  16
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ5(H155NW156F)

<400>  16
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acaacttctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  17
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ6(H155VW156T)

<400>  17

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Thr Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  18
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ6(H155VW156T)

<400>  18
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttacctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  19
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ7(W156M)

<400>  19

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Met Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  20
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ7(W156M)

<400>  20
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accacatgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  21
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ8(H155VW156M)

<400>  21

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Met Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  22
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ8(H155VW156M)

<400>  22
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttatgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  23
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ9(H155VW156R)

<400>  23

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Arg Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  24
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ9(H155VW156R)

<400>  24
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttcgttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  25
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ10(H155QW156F)

<400>  25

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Gln Phe Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  26
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ10(H155QW156F)

<400>  26
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accagttctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  27
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ11(H155LW156S)

<400>  27

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Ser Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  28
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ11(H155LW156S)

<400>  28
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgtcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  29
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ12(H155FW156G)

<400>  29

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Phe Gly Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  30
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ12(H155FW156G)

<400>  30
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acttcggttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  31
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ13(H155FW156L)

<400>  31

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Phe Leu Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  32
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ13(H155FW156L)

<400>  32
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acttcctgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  33
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ14(H155QW156L)

<400>  33

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Gln Leu Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  34
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ14(H155QW156L)

<400>  34
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accagctgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  35
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ15(H155VW156D)

<400>  35

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Asp Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  36
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ15(H155VW156D)

<400>  36
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttgactc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  37
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ16(H155MW156A)

<400>  37

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Met Ala Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  38
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ16(H155MW156A)

<400>  38
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acatggcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  39
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ17(H155LW156I)

<400>  39

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Ile Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  40
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ17(H155LW156I)

<400>  40
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgatctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  41
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ18(H155FW156M)

<400>  41

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Phe Met Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  42
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ18(H155FW156M)

<400>  42
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acttcatgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  43
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ19(H155FW156R)

<400>  43

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Phe Arg Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  44
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ19(H155FW156R)

<400>  44
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acttccgttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  45
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ20(H155AW156F)

<400>  45

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ala Phe Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  46
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ20(H155AW156F)

<400>  46
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgctttctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  47
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ21(H155PW156Y)

<400>  47

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Pro Tyr Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  48
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ21(H155PW156Y)

<400>  48
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acccgtactc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  49
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ22(W156T)

<400>  49

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Thr Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  50
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ22(W156T)

<400>  50
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accacacctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  51
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ23(H155V)

<400>  51

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Trp Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  52
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ23(H155V)

<400>  52
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgtttggtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  53
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ24(W156C)

<400>  53

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Cys Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  54
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ24(W156C)

<400>  54
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accactgctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  55
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ25(H155TW156F)

<400>  55

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Thr Phe Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  56
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ25(H155TW156F)

<400>  56
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acaccttctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  57
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ26(H155WW156I)

<400>  57

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Trp Ile Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  58
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ26(H155WW156I)

<400>  58
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct actggatctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  59
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ27(H155LW156L)

<400>  59

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Leu Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  60
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ27(H155LW156L)

<400>  60
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgctgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  61
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ28(H155PW156T)

<400>  61

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Pro Thr Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  62
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ28(H155PW156T)

<400>  62
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acccgacctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  63
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ29(H155CW156M)

<400>  63

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Cys Met Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  64
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ29(H155CW156M)

<400>  64
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct actgcatgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  65
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ30(H155IW156A)

<400>  65

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ile Ala Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  66
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ30(H155IW156A)

<400>  66
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acatcgcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  67
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ31(H155LW156A)

<400>  67

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Ala Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  68
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ31(H155LW156A)

<400>  68
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctggcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  69
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ32(W156F)

<400>  69

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Phe Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  70
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ32(W156F)

<400>  70
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accacttctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  71
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ33(H155TW156L)

<400>  71

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Thr Leu Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  72
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ33(H155TW156L)

<400>  72
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acaccctgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  73
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ34(H155VW156Y)

<400>  73

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Tyr Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  74
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ34(H155VW156Y)

<400>  74
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgtttactc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  75
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ35(H155IW156P)

<400>  75

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ile Pro Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  76
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ35(H155IW156P)

<400>  76
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acatcccgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  77
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ36(H155LW156F)

<400>  77

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Phe Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  78
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ36(H155LW156F)

<400>  78
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgttctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  79
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ37(H155VW156G)

<400>  79

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Gly Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  80
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ37(H155VW156G)

<400>  80
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttggttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  81
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ38(H155FW156T)

<400>  81

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Phe Thr Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  82
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ38(H155FW156T)

<400>  82
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acttcacctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  83
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ39(H155AW156M)

<400>  83

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ala Met Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  84
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ39(H155AW156M)

<400>  84
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgctatgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  85
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ40(H155VW156A)

<400>  85

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Ala Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  86
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ40(H155VW156A)

<400>  86
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttgcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900


<210>  87
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ41(H155LW156P)

<400>  87

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Pro Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  88
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ41(H155LW156P)

<400>  88
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgccgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  89
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ42(H155DW156L)

<400>  89

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Asp Leu Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  90
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ42(H155DW156L)

<400>  90
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgacctgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  91
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ43(H155NW156I)

<400>  91

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Asn Ile Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  92
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ43(H155NW156I)

<400>  92
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acaacatctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  93
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ44(H155HW156L)

<400>  93

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Leu Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  94
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ44(H155HW156L)

<400>  94
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accacctgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  95
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ45(H155VW156I)

<400>  95

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Val Ile Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  96
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ45(H155VW156I)

<400>  96
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgttatctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  97
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ46(H155LW156T)

<400>  97

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Thr Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  98
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ46(H155LW156T)

<400>  98
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgacctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  99
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ47(H155QW156I)

<400>  99

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Gln Ile Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  100
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ47(H155QW156I)

<400>  100
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accagatctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  101
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ48(H155IW156C)

<400>  101

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ile Cys Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  102
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ48(H155IW156C)

<400>  102
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acatctgctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  103
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ49(H155SW156M)

<400>  103

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ser Met Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  104
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ49(H155SW156M)

<400>  104
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct actctatgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  105
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ50(W156S)

<400>  105

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Ser Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  106
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ50(W156S)

<400>  106
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accactcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  107
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ51(W156V)

<400>  107

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Val Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  108
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ51(W156V)

<400>  108
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accacgtttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  109
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ52(H155AW156S)

<400>  109

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Ala Ser Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  110
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ52(H155AW156S)

<400>  110
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgcttcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  111
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ53(H155MW156F)

<400>  111

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Met Phe Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  112
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ53(H155MW156F)

<400>  112
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acatgttctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  113
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ54(H155EW156T)

<400>  113

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Glu Thr Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  114
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ54(H155EW156T)

<400>  114
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgaaacctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  115
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ55(W156A)

<400>  115

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr His Ala Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  116
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ55(W156A)

<400>  116
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct accacgcttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  117
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ56(H155EW156M)

<400>  117

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Glu Met Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  118
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ56(H155EW156M)

<400>  118
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgaaatgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  119
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ57(H155LW156G)

<400>  119

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Gly Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  120
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ57(H155LW156G)

<400>  120
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgggttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  121
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ58(H155LW156F)

<400>  121

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Phe Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  122
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ58(H155LW156F)

<400>  122
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgttctc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  123
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ59(H155EW156P)

<400>  123

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Glu Pro Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  124
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ59(H155EW156P)

<400>  124
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgaaccgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  125
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ60(H155LW156P)

<400>  125

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Leu Pro Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  126
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ60(H155LW156P)

<400>  126
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acctgccgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  127
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ61(H155GW156F)

<400>  127

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Gly Pro Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  128
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ61(H155GW156F)

<400>  128
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acggtccgtc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


<210>  129
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ±øͻ62(H155DW156R)

<400>  129

Met Pro Asp Leu Ala Asp Leu Phe Pro Gly Phe Gly Ser Glu Trp Ile 
1               5                   10                  15      


Asn Thr Ser Ser Gly Arg Ile Phe Ala Arg Val Gly Gly Asp Gly Pro 
            20                  25                  30          


Pro Leu Leu Leu Leu His Gly Phe Pro Gln Thr His Val Met Trp His 
        35                  40                  45              


Arg Val Ala Pro Lys Leu Ala Glu Arg Phe Lys Val Ile Val Ala Asp 
    50                  55                  60                  


Leu Pro Gly Tyr Gly Trp Ser Asp Met Pro Glu Ser Asp Glu Gln His 
65                  70                  75                  80  


Thr Pro Tyr Thr Lys Arg Ala Met Ala Lys Gln Leu Ile Glu Ala Met 
                85                  90                  95      


Glu Gln Leu Gly His Val His Phe Ala Leu Ala Gly His Asp Arg Gly 
            100                 105                 110         


Ala Arg Val Ser Tyr Arg Leu Ala Leu Asp Ser Pro Gly Arg Leu Ser 
        115                 120                 125             


Lys Leu Ala Val Leu Asp Ile Leu Pro Thr Tyr Glu Tyr Trp Gln Arg 
    130                 135                 140                 


Met Asn Arg Ala Tyr Ala Leu Lys Ile Tyr Asp Arg Ser Phe Leu Ala 
145                 150                 155                 160 


Gln Pro Ala Pro Leu Pro Glu Asn Leu Leu Gly Gly Asp Pro Asp Phe 
                165                 170                 175     


Tyr Val Lys Ala Lys Leu Ala Ser Trp Thr Arg Ala Gly Asp Leu Ser 
            180                 185                 190         


Ala Phe Asp Pro Arg Ala Val Glu His Tyr Arg Ile Ala Phe Ala Asp 
        195                 200                 205             


Pro Met Arg Arg His Val Met Cys Glu Asp Tyr Arg Ala Gly Ala Tyr 
    210                 215                 220                 


Ala Asp Phe Glu His Asp Lys Ile Asp Val Glu Ala Gly Asn Lys Ile 
225                 230                 235                 240 


Pro Val Pro Met Leu Ala Leu Trp Gly Ala Ser Gly Ile Ala Gln Ser 
                245                 250                 255     


Ala Ala Thr Pro Leu Asp Val Trp Arg Lys Trp Ala Ser Asp Val Gln 
            260                 265                 270         


Gly Ala Pro Ile Glu Ser Gly His Phe Leu Pro Glu Glu Ala Pro Asp 
        275                 280                 285             


Gln Thr Ala Glu Ala Leu Val Arg Phe Phe Ser Ala Ala Pro Gly Ser 
    290                 295                 300                 


<210>  130
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ±øͻ62(H155DW156R)

<400>  130
atgccggacc tggctgacct gttcccgggt ttcggttctg aatggatcaa cacctcttct       60

ggtcgtatct tcgctcgtgt tggtggtgac ggtccgccgc tgctgctgct gcacggtttc      120

ccgcagaccc acgttatgtg gcaccgtgtt gctccgaaac tggctgaacg tttcaaagtt      180

atcgttgctg acctgccggg ttacggttgg tctgacatgc cggaatctga cgaacagcac      240

accccgtaca ccaaacgtgc tatggctaaa cagctgatcg aagctatgga acagctgggt      300

cacgttcact tcgctctggc tggtcacgac cgtggtgctc gtgtttctta ccgtctggct      360

ctggactctc cgggtcgtct gtctaaactg gctgttctgg acatcctgcc gacctacgaa      420

tactggcagc gtatgaaccg tgcttacgct ctgaaaatct acgaccgttc tttcctggct      480

cagccggctc cgctgccgga aaacctgctg ggtggtgacc cggacttcta cgttaaagct      540

aaactggctt cttggacccg tgctggtgac ctgtctgctt tcgacccgcg tgctgttgaa      600

cactaccgta tcgctttcgc tgacccgatg cgtcgtcacg ttatgtgcga agactaccgt      660

gctggtgctt acgctgactt cgaacacgac aaaatcgacg ttgaagctgg taacaaaatc      720

ccggttccga tgctggctct gtggggtgct tctggtatcg ctcagtctgc tgctaccccg      780

ctggacgttt ggcgtaaatg ggcttctgac gttcagggtg ctccgatcga atctggtcac      840

ttcctgccgg aagaagctcc ggaccagacc gctgaagctc tggttcgttt cttctctgct      900

gctccgggtt ct                                                          912


