SEQUENCE LISTING

<110> University of Maryland, Baltimore

<120> Inhibitors of Cancer Biomarkers and Uses Thereof

<130> D7993PCT

<141> 2020-12-12

<150> US 63/082,065
<151> 2020-09-23

<150> US 62/947,214
<151> 2019-12-12

<160> 83

<210> 1
<211> 215
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA sequence of X-box binding protein-1 variant XV1
      first exon and C-terminus flanking sequence

<220> 
<221> misc_feature
<222> 1..174
<223> cDNA sequence of the first exon

<220> 
<221> misc_feature
<222> 175..215
<223> cDNA sequence of the C-terminus flanking sequence

<400> 1
ccggactgac cggatccgcc acgctgggaa cctagggcgg cccagggctc  50
ttttctgtac tttttaactc tctcgttaga gatgaccaga gctggggatg 100
cgggcacctg tcttccaggc cctcttgctg tgtggccgca gactggtggt 150
tcagcctctt aactcggaca tgaggaaact gaaaaacaga gtagcagctc 200
agactgccag agatc                                       215

<210> 2
<211> 224
<212> DNA
<213> Artificial Sequence

<220> 
<223> Genomic sequence of X-box binding protein-1 variant XV1
      first exon and C-terminus flanking sequence

<220> 
<221> misc_feature
<222> 1..174
<223> genomic sequence of the first exon

<220> 
<221> misc_feature
<222> 175..224
<223> genomic sequence of the C-terminus flanking sequence

<400> 2
ccggactgac cggatccgcc acgctgggaa cctagggcgg cccagggctc  50
ttttctgtac tttttaactc tctcgttaga gatgaccaga gctggggatg 100
cgggcacctg tcttccaggc cctcttgctg tgtggccgca gactggtggt 150
tcagcctctt aactcggaca tgaggtcgaa taatctgttt tggtttactg 200
ctatttctgg agaggcgcgg agct                             224

<210> 3
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 3
ggauccgccacgcugggaa    19

<210> 4
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 4
ccgccacgcu gggaaccua    19

<210> 5
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 5
cgccacgcug ggaaccuag    19

<210> 6
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 6
cggcccaggg cucuuuucu    19

<210> 7
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 7
gcccagggcu cuuuucugu    19

<210> 8
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 8
cccagggcuc uuuucugua    19

<210> 9
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 9
ccagggcucu uuucuguac    19

<210> 10
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 10
agggcucuuu ucuguacuu    19

<210> 11
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 11
gggcucuuuu cuguacuuu    19

<210> 12
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 12
ggcucuuuuc uguacuuuu    19

<210> 13
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 13
gcucuuuucu guacuuuuu    19
<210> 14
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 14
acuuuuuaac ucucucguu    19

<210> 15
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 15
cuuuuuaacu cucucguua    19

<210> 16
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 16
acucucucgu uagagauga    19

<210> 17
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 17
cucucucguu agagaugac    19

<210> 18
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 18
cucucguuag agaugacca    19

<210> 19
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 19
cucguuagag augaccaga    19

<210> 20
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 20
cguuagagau gaccagagc    19

<210> 21
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 21
agaugaccag agcugggga    19

<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 22
ggaugcgggc accugucuu    19

<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 23
ugcgggcacc ugucuucca    19

<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 24
cugucuucca ggcccucuu    19

<210> 25
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 25
cuugcugugu ggccgcaga    19

<210> 26
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 26
gccgcagacu ggugguuca    19

<210> 27
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 27
cagacuggug guucagccu    19

<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 28
gacugguggu ucagccucu    19

<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 29
acuggugguu cagccucuu    19

<210> 30
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 30
uggugguuca gccucuuaa    19

<210> 31
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 31
ggugguucag ccucuuaac    19

<210> 32
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 32
gugguucagc cucuuaacu    19

<210> 33
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 33
gguucagccu cuuaacucg    19

<210> 34
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 34
agccucuuaa cucggacau    19

<210> 35
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 35
gccucuuaac ucggacaug    19

<210> 36
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 36
ccucuuaacu cggacauga    19

<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 37
cucuuaacuc ggacaugag    19

<210> 38
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 38
ucggacauga ggaaacuga    19

<210> 39
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 39
cggacaugag gaaacugaa    19

<210> 40
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 40
ggacaugagg aaacugaaa    19

<210> 41
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 41
gacaugagga aacugaaaa    19

<210> 42
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sequence for inhibiting X-box binding protein-1
      variant XV1 mRNA

<400> 42
augaggaaac ugaaaaaca    19

<210> 43
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sense sequence for X-box binding protein-1 variant
      XV1 mRNA

<220>
<221>  misc_feature
<222>  20..21
<223>  n is deoxythymidine

<400> 43
ccucuuaacu cggacaugan n 21

<210> 44
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sense sequence for X-box binding protein-1 variant
      XV1 mRNA

<220>
<221>  misc_feature
<222>  20..21
<223>  n is deoxythymidine

<400> 44
cucucguuag agaugaccan n 21

<210> 45
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sense sequence for X-box binding protein-1 mRNA

<220>
<221>  misc_feature
<222>  20..21
<223>  n is deoxythymidine

<400> 45
gaccccuaaa guucugcuun n 21

<210> 46
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sense sequence for Tubulin Tyrosine Ligase Like 6
      (TTLL6) mRNA

<220>
<221>  misc_feature
<222>  20..21
<223>  n is deoxythymidine

<400> 46
gaaacguaug agaaggaaan n 21

<210> 47
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sense sequence for Tubulin Tyrosine Ligase Like 6
      (TTLL6) mRNA

<220>
<221>  misc_feature
<222>  20..21
<223>  n is deoxythymidine

<400> 47
gcuuugcgac gaccucuuan n 21

<210> 48
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA sense sequence for Tubulin Tyrosine Ligase Like 6
      (TTLL6) mRNA

<220>
<221>  misc_feature
<222>  20..21
<223>  n is deoxythymidine

<400> 48
gggauuaaug aaacugccan n 21

<210> 49
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide sequence common to all X-box binding protein-1 
      Proteins and X-box binding protein-1 variant proteins

<220>
<221> SITE
<222> 18
<223> Cysteine is added at position 18 and is conjugated to 
      keyhole limpet hemocyanin

<400> 49
Arg Gln Arg Leu Gly Met Asp Ala Leu Val Ala Glu Glu Glu Ala
1               5                   10                  15
Glu Ala Cys


<210> 50
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1

<400> 50
gaggagaagg cgctgag     17

<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1

<400> 51
cactggcctc acttcattc     19

<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 variant XV1

<400> 52
ggtggttcag cctcttaact c     21

<210> 53
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 variant XV1

<400> 53
cactggcctc acttcattc     19

<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 spliced
      variant XV1s

<400> 54
ggtggttcag cctcttaact c     21

<210> 55
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 spliced
      variant XV1s

<400> 55
ctgcacctgc tgcgtactc     19

<210> 56
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 unspliced
      variant XV1s

<400> 56
ggtggttcag cctcttaact c     21

<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 unspliced
      variant XV1s

<400> 57
gaggtgcacg tagtctgag     19

<210> 58
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for beta-actin

<400> 58
caccaactgg gacgacat     18

<210> 59
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for beta-actin

<400> 59
acagcctgga tagcaacg     18

<210> 60
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for Tubulin Tyrosine Ligase Like 6

<400> 60
gcgaagccct tcagttctc     19

<210> 61
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for Tubulin Tyrosine Ligase Like 6

<400> 61
gctcctctca catccttttt gg     22

<210> 62
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 variant XV1

<400> 62
ggtgcaggcc cagttgtc     18

<210> 63
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 variant XV1

<400> 63
tgctgcggac tcagcagac     19

<210> 64
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 variant XV1 

<400> 64
cgggtctgca gaatccgcag cac     23

<210> 65
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 variant XV1 

<400> 65
gtgctgcgga ttctgcagac ccg     23

<210> 66
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for site-directed mutagenesis to create
      sirna resistant XV1

<400> 66
cctcttaact ctgatatgag gaaactg     27

<210> 67
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for site-directed mutagenesis to create
      sirna resistant XV1

<400> 67
cagtttcctc atatcagagt taagagg     27

<210> 68
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 unspliced
      variant XV1u

<220>
<221> modified_base
<222> 32
<223> Hemagglutinin (HA) tag at position 32

<400> 68
ctttgctagc caccatgcgg gcacctgtct tc     32

<210> 69
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 unspliced
      variant XV1u

<220>
<221> modified_base
<222> 62
<223> Hemagglutinin (HA) tag at position 62

<400> 69
gtttgcggcc gcttaagcgt aatctggaac atcgtatggg tagttcatta  50
atggcttcca gc                                           62

<210> 70
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 variant XV1

<400> 70
ctttgctagc caccatgcgg gcacctgtct tc   32

<210> 71
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1 variant XV1

<400> 71
gaaaggatcc gttagacact aatcagctgg g    31

<210> 72
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for Tubulin Tyrosine Ligase Like 6

<400> 72
cttcactagt gcagccaatg ggagcgttac tccttcatc     39

<210> 73
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for Tubulin Tyrosine Ligase Like 6

<400> 73
gacttgcggc cgcttagctc ctctcacatc ctttttgg   38

<210> 74
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1

<400> 74
gttcactagt gcgtagtctg gagctatg   28

<210> 75
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence for X-box binding protein-1

<400> 75
ctttggatcc agacaggctt ctctgctatc   30

<210> 76
<211> 171
<212> DNA
<213> Artificial Sequence

<220> 
<223> Unique sequence of X-box binding protein-1 alternate
      spliced variant 4 (XBP1AS4)

<400> 76
ccggactgac cggatccgcc acgctgggaa cctagggcgg cccagggctc  50
ttttctgtac tttttaactc tctcgttaga gatgaccaga gctggggatg 100
cgggcacctg tcttccaggc cctcttgctg tgtggccgca gactggtggt 150
tcagcctctt aactcggaca t                                171

<210> 77
<211> 1690
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of full length X-box binding protein-1
      alternate spliced variant 4 (XBP1AS4)

<400> 77
ccggactgac cggatccgcc acgctgggaa cctagggcgg cccagggctc   50
ttttctgtac tttttaactc tctcgttaga gatgaccaga gctggggatg  100
cgggcacctg tcttccaggc cctcttgctg tgtggccgca gactggtggt  150
tcagcctctt aactcggaca tgaggaaact gaaaaacaga gtagcagctc  200
agactgccag agatcgaaag aaggctcgaa tgagtgagct ggaacagcaa  250
gtggtagatt tagaagaaga gaaccaaaaa cttttgctag aaaatcagct  300
tttacgagag aaaactcatg gccttgtagt tgagaaccag gagttaagac  350
agcgcttggg gatggatgcc ctggttgctg aagaggaggc ggaagccaag  400
gggaatgaag tgaggccagt ggccgggtct gctgagtccg cagcactcag  450
actacgtgca cctctgcagc aggtgcaggc ccagttgtca cccctccaga  500
acatctcccc atggattctg gcggtattga ctcttcagat tcagagtctg  550
atatcctgtt gggcattctg gacaacttgg acccagtcat gttcttcaaa  600
tgcccttccc cagagcctgc cagcctggag gagctcccag aggtctaccc  650
agaaggaccc agttccttac cagcctccct ttctctgtca gtggggacgt  700
catcagccaa gctggaagcc attaatgaac taattcgttt tgaccacata  750
tataccaagc ccctagtctt agagataccc tctgagacag agagccaagc  800
taatgtggta gtgaaaatcg aggaagcacc tctcagcccc tcagagaatg  850
atcaccctga attcattgtc tcagtgaagg aagaacctgt agaagatgac  900
ctcgttccgg agctgggtat ctcaaatctg ctttcatcca gccactgccc  950
aaagccatct tcctgcctac tggatgctta cagtgactgt ggatacgggg 1000
gttccctttc cccattcagt gacatgtcct ctctgcttgg tgtaaaccat 1050
tcttgggagg acacttttgc caatgaactc tttccccagc tgattagtgt 1100
ctaaggaatg atccaatact gttgcccttt tccttgacta ttacactgcc 1150
tggaggatag cagagaagcc tgtctgtact tcattcaaaa agccaaaata 1200
gagagtatac agtcctagag aattcctcta tttgttcaga tctcatagat 1250
gacccccagg tattgtcttt tgacatccag cagtccaagg tattgagaca 1300
tattactgga agtaagaaat attactataa ttgagaacta cagcttttaa 1350
gattgtactt ttatcttaaa agggtggtag ttttccctaa aatacttatt 1400
atgtaagggt cattagacaa atgtcttgaa gtagacatgg aatttatgaa 1450
tggttcttta tcatttctct tccccctttt tggcatcctg gcttgcctcc 1500
agttttaggt cctttagttt gcttctgtaa gcaacgggaa cacctgctga 1550
gggggctctt tccctcatgt atacttcaag taagatcaag aatcttttgt 1600
gaaattatag aaatttacta tgtaaatgct tgatggaatt ttttcctgct 1650
agtgtagctt ctgaaaggtg ctttctccat ttatttaaaa            1690

<210> 78
<211> 200
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence for X-box binding protein-1 alternate spliced
      variant 4 (XBP1AS4)

<400> 78
ccggactgac cggatccgcc acgctgggaa cctagggcgg cccagggctc  50
ttttctgtac tttttaactc tctcgttaga gatgaccaga gctggggatg 100
cgggcacctg tcttccaggc cctcttgctg tgtggccgca gactggtggt 150
tcagcctctt aactcggaca tgaggaaact gaaaaacaga gtagcagctc 200

<210> 79
<211> 211
<212> PRT
<213> Artificial Sequence

<220> 
<223> Unspliced form of X-box binding protein-1 alternate
      spliced variant 4 (XBP1AS4)

<400> 79
Met Arg Ala Pro Val Phe Gln Ala Leu Leu Leu Cys Gly Arg Arg
1               5                   10                  15
Leu Val Val Gln Pro Leu Asn Ser Asp Met Arg Lys Leu Lys Asn
                20                  25                  30
Arg Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met
                35                  40                  45
Ser Glu Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln
                50                  55                  60
Lys Leu Leu Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly
                65                  70                  75
Leu Val Val Glu Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp
                80                  85                  90
Ala Leu Val Ala Glu Glu Glu Ala Glu Ala Lys Gly Asn Glu Val
                95                  100                 105
Arg Pro Val Ala Gly Ser Ala Glu Ser Ala Ala Leu Arg Leu Arg
                110                 115                 120
Ala Pro Leu Gln Gln Val Gln Ala Gln Leu Ser Pro Leu Gln Asn
                125                 130                 135
Ile Ser Pro Trp Ile Leu Ala Val Leu Thr Leu Gln Ile Gln Ser
                140                 145                 150
Leu Ile Ser Cys Trp Ala Phe Trp Thr Thr Trp Thr Gln Ser Cys
                155                 160                 165
Ser Ser Asn Ala Leu Pro Gln Ser Leu Pro Ala Trp Arg Ser Ser
                170                 175                 180
Gln Arg Ser Thr Gln Lys Asp Pro Val Pro Tyr Gln Pro Pro Phe
                185                 190                 195
Leu Cys Gln Trp Gly Arg His Gln Pro Ser Trp Lys Pro Leu Met
                200                 205                 210
Asn
   
<210> 80
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> Spliced form of X-box binding protein-1 alternate
      spliced variant 4 (XBP1AS4)

<400> 80
Met Arg Ala Pro Val Phe Gln Ala Leu Leu Leu Cys Gly Arg Arg
1               5                   10                  15
Leu Val Val Gln Pro Leu Asn Ser Asp Met Arg Lys Leu Lys Asn
                20                  25                  30
Arg Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met
                35                  40                  45
Ser Glu Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln
                50                  55                  60
Lys Leu Leu Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly
                65                  70                  75
Leu Val Val Glu Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp
                80                  85                  90
Ala Leu Val Ala Glu Glu Glu Ala Glu Ala Lys Gly Asn Glu Val
                95                  100                 105
Arg Pro Val Ala Gly Ser Ala Glu Ser Ala Ala Gly Ala Gly Pro
                110                 115                 120
Val Val Thr Pro Pro Glu His Leu Pro Met Asp Ser Gly Gly Ile
                125                 130                 135
Asp Ser Ser Asp Ser Glu Ser Asp Ile Leu Leu Gly Ile Leu Asp
                140                 145                 150
Asn Leu Asp Pro Val Met Phe Phe Lys Cys Pro Ser Pro Glu Pro
                155                 160                 165
Ala Ser Leu Glu Glu Leu Pro Glu Val Tyr Pro Glu Gly Pro Ser
                170                 175                 180
Ser Leu Pro Ala Ser Leu Ser Leu Ser Val Gly Thr Ser Ser Ala
                185                 190                 195
Lys Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe Asp His Ile Tyr
                200                 205                 210
Thr Lys Pro Leu Val Leu Glu Ile Pro Ser Glu Thr Glu Ser Gln
                215                 220                 225
Ala Asn Val Val Val Lys Ile Glu Glu Ala Pro Leu Ser Pro Ser
                230                 235                 240
Glu Asn Asp His Pro Glu Phe Ile Val Ser Val Lys Glu Glu Pro
                245                 250                 255
Val Glu Asp Asp Leu Val Pro Glu Leu Gly Ile Ser Asn Leu Leu
                260                 265                 270
Ser Ser Ser His Cys Pro Lys Pro Ser Ser Cys Leu Leu Asp Ala
                275                 280                 285
Tyr Ser Asp Cys Gly Tyr Gly Gly Ser Leu Ser Pro Phe Ser Asp
                290                 295                 300
Met Ser Ser Leu Leu Gly Val Asn His Ser Trp Glu Asp Thr Phe
                305                 310                 315
Ala Asn Glu Leu Phe Pro Gln Leu Ile Ser Val
                320                 325

<210> 81
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> N-terminal aminoacids of X-box binding protein-1
      alternate spliced variant 4 (XBP1AS4)

<400> 81
Met Arg Ala Pro Val Phe Gln Ala Leu Leu Leu Cys Gly Arg Arg
1               5                   10                  15
Leu Val Val Gln Pro Leu Asn Ser Asp Met
                20                  25

<210> 82
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> N-terminal aminoacids of X-box binding protein-1
      alternate spliced variant 4 (XBP1AS4)

<400> 82
Met Arg Ala Pro Val Phe Gln Ala Leu Leu Leu Cys Gly Arg Arg
1               5                   10                  15
Leu Val Val Gln Pro Leu Asn Ser Asp Met Arg Lys Leu Lys Asn
                20                  25                  30
Arg Val Ala Ala Gln Thr
                35

<210> 83
<211> 75
<212> PRT
<213> Artificial Sequence

<220> 
<223> N-terminal amino acids of X-box binding protein-1
      alternate spliced variant 4 (XBP1AS4)

<400> 83
Met Val Val Val Ala Ala Ala Pro Asn Pro Ala Asp Gly Thr Pro
1               5                   10                  15
Lys Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Ala Ala Gly Ala
                20                  25                  30
Pro Ala Gly Gln Ala Leu Pro Leu Met Val Pro Ala Gln Arg Gly
                35                  40                  45
Ala Ser Pro Glu Ala Ala Ser Gly Gly Leu Pro Gln Ala Arg Lys
                50                  55                  60
Arg Gln Arg Leu Thr His Leu Ser Pro Glu Glu Lys Ala Leu Arg
                65                  70                  75