                         SEQUENCE LISTING

<110>  Sanofi Biotechnology
 
<120>  METHODS FOR TREATING DIGITALLY-IDENTIFIED IL-4/IL-13 RELATED 
       DISORDERS

<130>  37488-0781WO1 and 37488-0781001

<140>  US 62/945,807
<141>  2019-12-09

<140>  US 63/028,919
<141>  2020-05-22

<140>  EP 20315280.6 
<141>  2020-05-29

<140>  EP 20315281.4
<141>  2020-05-29

<140>  EP 20315450.5
<141>  2020-11-13

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha HC CDR1

<400>  1

Gly Phe Thr Phe Arg Asp Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha HC CDR2

<400>  2

Ile Ser Gly Ser Gly Gly Asn Thr 
1               5               


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha HC CDR3

<400>  3

Ala Lys Asp Arg Leu Ser Ile Thr Ile Arg Pro Arg Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha LC CDR1

<400>  4

Gln Ser Leu Leu Tyr Ser Ile Gly Tyr Asn Tyr 
1               5                   10      


<210>  5
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha LC CDR2

<400>  5

Leu Gly Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha LC CDR3

<400>  6

Met Gln Ala Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  misc_feature
<223>  Anti-IL-4R-alpha HC CDR1

<400>  7
ggattcacct ttagagacta tgcc                                              24


<210>  8
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  misc_feature
<223>  Anti-IL-4R-alpha HC CDR2

<400>  8
attagtggtt ccggtggtaa caca                                              24


<210>  9
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  misc_feature
<223>  Anti-IL-4R-alpha HC CDR3

<400>  9
gcgaaagatc gactctctat aacaattcgc ccacgctatt atggtttgga cgtc             54


<210>  10
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  misc_feature
<223>  Anti-IL-4R-alpha LC CDR1

<400>  10
cagagcctcc tgtatagtat tggatacaac tat                                    33


<210>  11
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  misc_feature
<223>  Anti-IL-4R-alpha LC CDR2

<400>  11
ttgggttct                                                                9


<210>  12
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  misc_feature
<223>  Anti-IL-4R-alpha LC CDR3

<400>  12
atgcaagctc tacaaactcc gtacact                                           27


<210>  13
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha Heavy chain variable region

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Leu Ser Ile Thr Ile Arg Pro Arg Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  14
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha Light chain variable region

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ile Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Ser Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  misc_feature
<223>  Anti-IL-4R-alpha Heavy chain variable region

<400>  15
gaggtgcagc tggtggagtc tgggggaggc ttggaacagc cgggggggtc cctgagactc       60

tcctgtgcag gctctggatt cacctttaga gactatgcca tgacctgggt ccgccaggct      120

ccagggaagg gactggagtg ggtctcatct attagtggtt ccggtggtaa cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcga      300

ctctctataa caattcgccc acgctattat ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cc                                                          372


<210>  16
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  misc_feature
<223>  Anti-IL-4R-alpha Light chain variable region

<400>  16
gacatcgtga tgacccagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg tatagtattg gatacaacta tttggattgg      120

tacctgcaga agtcagggca gtctccacag ctccttatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttgggttt tattactgca tgcaagctct acaaactccg      300

tacacttttg gccaggggac caagctggag atcaaa                                336


<210>  17
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha Heavy Chain

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Glu Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Leu Ser Ile Thr Ile Arg Pro Arg Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly 
    450     


<210>  18
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of peptide that binds IL-4R


<220>
<221>  MISC_FEATURE
<223>  Anti-IL-4R-alpha Light Chain

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ile Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Ser Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  19
<211>  207
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human IL-4R

<400>  19

Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met Ser Ile 
1               5                   10                  15      


Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser Thr Glu 
            20                  25                  30          


Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala His Thr 
        35                  40                  45              


Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His Leu Leu 
    50                  55                  60                  


Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu Trp Ala 
65                  70                  75                  80  


Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu His Val 
                85                  90                  95      


Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val Ser Asp 
            100                 105                 110         


Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn Tyr Leu 
        115                 120                 125             


Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn Asp Pro 
    130                 135                 140                 


Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg 
145                 150                 155                 160 


Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val 
                165                 170                 175     


Arg Ala Trp Ala Gln Cys Tyr Asn Thr Thr Trp Ser Glu Trp Ser Pro 
            180                 185                 190         


Ser Thr Lys Trp His Asn Ser Tyr Arg Glu Pro Phe Glu Gln His 
        195                 200                 205         


