                         SEQUENCE LISTING

<110>  Versiti Blood Research Institute Foundation, Inc.
       Cui, Weiguo
 
<120>  BCG CAR CONSTRUCTS AND METHODS OF THEIR MANUFACTURE AND USE

<130>  160180.00151

<150>  62/945,406
<151>  2019-12-09

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  295
<212>  PRT
<213>  Mus musculus

<400>  1

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Ile Cys Pro Met Ser Ser Pro Gln Ser Leu Lys Thr Arg Thr Leu 
    130                 135                 140                 


Thr Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr 
145                 150                 155                 160 


Gly Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
                165                 170                 175     


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 
            180                 185                 190         


Phe Thr Gly Tyr Tyr Met Asn Trp Val Asn Thr Thr Tyr Asn Gln Lys 
        195                 200                 205             


Phe Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                245                 250                 255     


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
            260                 265                 270         


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
        275                 280                 285             


Val Lys Gly Tyr Phe Pro Glu 
    290                 295 


<210>  2
<211>  248
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
    130                 135                 140                 


Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser 
145                 150                 155                 160 


Tyr Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Leu Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu 
            180                 185                 190         


Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe 
        195                 200                 205             


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Gly Gly Leu Arg Arg Gly Asp Tyr Phe Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Leu Thr Val Ser Ser 
                245             


<210>  3
<211>  317
<212>  PRT
<213>  Mus musculus

<400>  3

Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser 
        115                 120                 125             


Thr Ser Gly Ser Gly Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Ile Cys Pro Met Ser Ser Pro Gln Ser 
145                 150                 155                 160 


Leu Lys Thr Arg Thr Leu Thr Met Gly Trp Asn Trp Ile Phe Ile Leu 
                165                 170                 175     


Ile Leu Ser Val Thr Thr Gly Val His Ser Glu Val Gln Leu Gln Gln 
            180                 185                 190         


Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
        195                 200                 205             


Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Tyr Met Asn Trp Val Asn 
    210                 215                 220                 


Thr Thr Tyr Asn Gln Lys Phe Lys Ala Lys Ala Thr Leu Thr Val Asp 
225                 230                 235                 240 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu 
                245                 250                 255     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Arg Asp Phe Asp Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        275                 280                 285             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    290                 295                 300                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
305                 310                 315         


<210>  4
<211>  270
<212>  PRT
<213>  Mus musculus

<400>  4

Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser 
        115                 120                 125             


Thr Ser Gly Ser Gly Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Lys Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Phe Ser Leu Thr Ser Tyr Ala Ile Ser Trp Val Arg Gln Pro Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Thr Gly Gly Gly Thr 
        195                 200                 205             


Asn Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Arg Tyr Tyr Cys Ala Arg Gly Gly Leu Arg Arg Gly Asp Tyr 
                245                 250                 255     


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            260                 265                 270 


<210>  5
<211>  298
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Tyr Thr Ile 
            20                  25                  30          


Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met Glu 
        35                  40                  45              


Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp Thr 
                85                  90                  95      


Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val Thr 
            100                 105                 110         


Val Leu Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
        115                 120                 125             


Ser Thr Lys Gly Ile Cys Pro Met Ser Ser Pro Gln Ser Leu Lys Thr 
    130                 135                 140                 


Arg Thr Leu Thr Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser 
145                 150                 155                 160 


Val Thr Thr Gly Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro 
                165                 170                 175     


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser 
            180                 185                 190         


Gly Tyr Ser Phe Thr Gly Tyr Tyr Met Asn Trp Val Asn Thr Thr Tyr 
        195                 200                 205             


Asn Gln Lys Phe Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
            260                 265                 270         


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
        275                 280                 285             


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
    290                 295             


<210>  6
<211>  251
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Tyr Thr Ile 
            20                  25                  30          


Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met Glu 
        35                  40                  45              


Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp Thr 
                85                  90                  95      


Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val Thr 
            100                 105                 110         


Val Leu Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
        115                 120                 125             


Ser Thr Lys Gly Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Thr Ser Tyr Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Leu Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn 
            180                 185                 190         


Ser Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser 
        195                 200                 205             


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Gly Leu Arg Arg Gly Asp Tyr Phe Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
                245                 250     


<210>  7
<211>  293
<212>  PRT
<213>  Mus musculus

<400>  7

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Thr 
            100                 105                 110         


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Ile 
        115                 120                 125             


Cys Pro Met Ser Ser Pro Gln Ser Leu Lys Thr Arg Thr Leu Thr Met 
    130                 135                 140                 


Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly Val 
145                 150                 155                 160 


His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
                165                 170                 175     


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            180                 185                 190         


Gly Tyr Tyr Met Asn Trp Val Asn Thr Thr Tyr Asn Gln Lys Phe Lys 
        195                 200                 205             


Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
            260                 265                 270         


Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys 
        275                 280                 285             


Gly Tyr Phe Pro Glu 
    290             


<210>  8
<211>  246
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Thr 
            100                 105                 110         


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln 
        115                 120                 125             


Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
    130                 135                 140                 


Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Ala 
145                 150                 155                 160 


Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
                165                 170                 175     


Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys Ser 
            180                 185                 190         


Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Gly Gly Leu Arg Arg Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Thr Leu Thr Val Ser Ser 
                245     


<210>  9
<211>  166
<212>  PRT
<213>  Mus musculus

<400>  9

Ile Cys Pro Met Ser Ser Pro Gln Ser Leu Lys Thr Arg Thr Leu Thr 
1               5                   10                  15      


Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
            20                  25                  30          


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
        35                  40                  45              


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
    50                  55                  60                  


Thr Gly Tyr Tyr Met Asn Trp Val Asn Thr Thr Tyr Asn Gln Lys Phe 
65                  70                  75                  80  


Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
                85                  90                  95      


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            100                 105                 110         


Ala Arg Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
        115                 120                 125             


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
    130                 135                 140                 


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Gly Tyr Phe Pro Glu 
                165     


<210>  10
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  10

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Leu Arg Arg Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  11
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  12
<211>  133
<212>  PRT
<213>  Mus musculus

<400>  12

Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser 
        115                 120                 125             


Thr Ser Gly Ser Gly 
    130             


<210>  13
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  13

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Tyr Thr Ile 
            20                  25                  30          


Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met Glu 
        35                  40                  45              


Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp Thr 
                85                  90                  95      


Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val Thr 
            100                 105                 110         


Val Leu 
        


<210>  14
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  14

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  15
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  16
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  16

Cys Ala Arg Arg Arg Asp Phe Asp Tyr Trp 
1               5                   10  


<210>  17
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  17

Gly Phe Ser Leu Thr Ser Tyr Ala 
1               5               


<210>  18
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  18

Ile Trp Thr Gly Gly Gly Thr 
1               5           


<210>  19
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  19

Cys Ala Arg Gly Gly Leu Arg Arg Gly Asp Tyr Phe Asp Tyr Trp 
1               5                   10                  15  


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr 
1               5                   10  


<210>  21
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  21

Cys Gln His Ser Trp Glu Ile Pro Tyr Thr Phe 
1               5                   10      


<210>  22
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  22

Gln Asp Ile Asn Lys Tyr 
1               5       


<210>  23
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  23

Cys Leu Gln Tyr Asp Asn Leu Tyr Thr Phe 
1               5                   10  


<210>  24
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  24

Ser Gln His Ser Tyr Thr 
1               5       


<210>  25
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  25

Leu Lys Lys Asp Gly Ser His 
1               5           


<210>  26
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  26

Cys Gly Val Gly Asp Thr Ile Lys Glu Gln Phe Val Tyr Val Phe 
1               5                   10                  15  


<210>  27
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  27

Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   


<210>  28
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  28

Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe 
1               5                   10      


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Linker sequence

<400>  29

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  30
<211>  885
<212>  DNA
<213>  Mus musculus

<400>  30
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaaggctcca cctctggatc cggcaagccc      360

ggatctggcg agggatccac caagggcata tgtccaatgt cctctccaca atccctgaag      420

acacggactc taactatggg atggaactgg atctttattt taatcctgtc agtaactaca      480

ggtgtccact ctgaggtcca gctgcagcag tctggacctg agctggtgaa gcctggggct      540

tcagtgaaga tatcctgcaa ggcttctggt tactcattca ctggctacta catgaactgg      600

gtgaatacta cctacaacca gaagttcaag gccaaggcca cattgactgt agacaaatcc      660

tccagcacag cctacatgca gctcaagagc ctgacatctg aggactctgc agtctattac      720

tgtgcaagac ggagggactt tgactactgg ggccaaggca ccactctcac agtctcctca      780

gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac      840

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgag                      885


<210>  31
<211>  744
<212>  DNA
<213>  Mus musculus

<400>  31
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac      300

acgttcggag gggggaccaa gctggaaata aaaggctcca cctctggatc cggcaagccc      360

ggatctggcg agggatccac caagggccag gtgcagctga aggagtcagg acctggcctg      420

gtggcgccct cacagagcct gtccatcaca tgcactgtct ctgggttctc attaaccagc      480

tatgctataa gctgggttcg ccagccacca ggaaagggtc tggagtggct tggagtaata      540

tggactggtg gaggcacaaa ttataattca gctctcaaat ccagactgag catcagcaaa      600

gacaactcca agagtcaagt tttcttaaaa atgaacagtc tgcaaactga tgacacagcc      660

aggtactact gtgccagagg gggattacga cggggggact actttgacta ctggggccaa      720

ggcaccactc tcacagtctc ctca                                             744


<210>  32
<211>  930
<212>  DNA
<213>  Mus musculus

<400>  32
atgagaccgt ctattcagtt cctggggctc ttgttgttct ggcttcatgg tgctcagtgt       60

gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc      120

atcacttgca aggcaagcca agacattaac aagtatatag cttggtacca acacaagcct      180

ggaaaaggtc ctaggctgct catacattac acatctacat tacagccagg catcccatca      240

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      300

gaagatattg caacttatta ttgtctacag tatgataatc tgtacacgtt cggagggggg      360

accaagctgg aaataaaagg ctccacctct ggatccggca agcccggatc tggcgaggga      420

tccaccaagg gcatatgtcc aatgtcctct ccacaatccc tgaagacacg gactctaact      480

atgggatgga actggatctt tattttaatc ctgtcagtaa ctacaggtgt ccactctgag      540

gtccagctgc agcagtctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      600

tgcaaggctt ctggttactc attcactggc tactacatga actgggtgaa tactacctac      660

aaccagaagt tcaaggccaa ggccacattg actgtagaca aatcctccag cacagcctac      720

atgcagctca agagcctgac atctgaggac tctgcagtct attactgtgc aagacggagg      780

gactttgact actggggcca aggcaccact ctcacagtct cctcagccaa aacgacaccc      840

ccatctgtct atccactggc ccctggatct gctgcccaaa ctaactccat ggtgaccctg      900

ggatgcctgg tcaagggcta tttccctgag                                       930


<210>  33
<211>  789
<212>  DNA
<213>  Mus musculus

<400>  33
atgagaccgt ctattcagtt cctggggctc ttgttgttct ggcttcatgg tgctcagtgt       60

gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc      120

atcacttgca aggcaagcca agacattaac aagtatatag cttggtacca acacaagcct      180

ggaaaaggtc ctaggctgct catacattac acatctacat tacagccagg catcccatca      240

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      300

gaagatattg caacttatta ttgtctacag tatgataatc tgtacacgtt cggagggggg      360

accaagctgg aaataaaagg ctccacctct ggatccggca agcccggatc tggcgaggga      420

tccaccaagg gccaggtgca gctgaaggag tcaggacctg gcctggtggc gccctcacag      480

agcctgtcca tcacatgcac tgtctctggg ttctcattaa ccagctatgc tataagctgg      540

gttcgccagc caccaggaaa gggtctggag tggcttggag taatatggac tggtggaggc      600

acaaattata attcagctct caaatccaga ctgagcatca gcaaagacaa ctccaagagt      660

caagttttct taaaaatgaa cagtctgcaa actgatgaca cagccaggta ctactgtgcc      720

agagggggat tacgacgggg ggactacttt gactactggg gccaaggcac cactctcaca      780

gtctcctca                                                              789


<210>  34
<211>  894
<212>  DNA
<213>  Mus musculus

<400>  34
caacttgtgc tcactcagtc atcttcagcc tctttctccc tgggagcctc agcaaaactc       60

acgtgcacct tgagtagtca gcacagttac accattgaat ggtatcagca acagccactc      120

aagcctccta agtatgtgat ggagcttaag aaagatggaa gccacagcac aggtgatggg      180

attcctgatc gcttctctgg atccagctct ggtgctgatc gctaccttag catttccaac      240

atccagcctg aagatgaagc aatatacatc tgtggtgtgg gtgatacaat taaggaacaa      300

tttgtgtatg ttttcggcgg tggaaccaag gtcactgtcc taggctccac ctctggatcc      360

ggcaagcccg gatctggcga gggatccacc aagggcatat gtccaatgtc ctctccacaa      420

tccctgaaga cacggactct aactatggga tggaactgga tctttatttt aatcctgtca      480

gtaactacag gtgtccactc tgaggtccag ctgcagcagt ctggacctga gctggtgaag      540

cctggggctt cagtgaagat atcctgcaag gcttctggtt actcattcac tggctactac      600

atgaactggg tgaatactac ctacaaccag aagttcaagg ccaaggccac attgactgta      660

gacaaatcct ccagcacagc ctacatgcag ctcaagagcc tgacatctga ggactctgca      720

gtctattact gtgcaagacg gagggacttt gactactggg gccaaggcac cactctcaca      780

gtctcctcag ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc      840

caaactaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgag            894


<210>  35
<211>  753
<212>  DNA
<213>  Mus musculus

<400>  35
caacttgtgc tcactcagtc atcttcagcc tctttctccc tgggagcctc agcaaaactc       60

acgtgcacct tgagtagtca gcacagttac accattgaat ggtatcagca acagccactc      120

aagcctccta agtatgtgat ggagcttaag aaagatggaa gccacagcac aggtgatggg      180

attcctgatc gcttctctgg atccagctct ggtgctgatc gctaccttag catttccaac      240

atccagcctg aagatgaagc aatatacatc tgtggtgtgg gtgatacaat taaggaacaa      300

tttgtgtatg ttttcggcgg tggaaccaag gtcactgtcc taggctccac ctctggatcc      360

ggcaagcccg gatctggcga gggatccacc aagggccagg tgcagctgaa ggagtcagga      420

cctggcctgg tggcgccctc acagagcctg tccatcacat gcactgtctc tgggttctca      480

ttaaccagct atgctataag ctgggttcgc cagccaccag gaaagggtct ggagtggctt      540

ggagtaatat ggactggtgg aggcacaaat tataattcag ctctcaaatc cagactgagc      600

atcagcaaag acaactccaa gagtcaagtt ttcttaaaaa tgaacagtct gcaaactgat      660

gacacagcca ggtactactg tgccagaggg ggattacgac ggggggacta ctttgactac      720

tggggccaag gcaccactct cacagtctcc tca                                   753


<210>  36
<211>  879
<212>  DNA
<213>  Mus musculus

<400>  36
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ttgggtgttc      300

ggtggaggaa ccaaactgac tgtcctaggc tccacctctg gatccggcaa gcccggatct      360

ggcgagggat ccaccaaggg catatgtcca atgtcctctc cacaatccct gaagacacgg      420

actctaacta tgggatggaa ctggatcttt attttaatcc tgtcagtaac tacaggtgtc      480

cactctgagg tccagctgca gcagtctgga cctgagctgg tgaagcctgg ggcttcagtg      540

aagatatcct gcaaggcttc tggttactca ttcactggct actacatgaa ctgggtgaat      600

actacctaca accagaagtt caaggccaag gccacattga ctgtagacaa atcctccagc      660

acagcctaca tgcagctcaa gagcctgaca tctgaggact ctgcagtcta ttactgtgca      720

agacggaggg actttgacta ctggggccaa ggcaccactc tcacagtctc ctcagccaaa      780

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg      840

gtgaccctgg gatgcctggt caagggctat ttccctgag                             879


<210>  37
<211>  738
<212>  DNA
<213>  Mus musculus

<400>  37
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ttgggtgttc      300

ggtggaggaa ccaaactgac tgtcctaggc tccacctctg gatccggcaa gcccggatct      360

ggcgagggat ccaccaaggg ccaggtgcag ctgaaggagt caggacctgg cctggtggcg      420

ccctcacaga gcctgtccat cacatgcact gtctctgggt tctcattaac cagctatgct      480

ataagctggg ttcgccagcc accaggaaag ggtctggagt ggcttggagt aatatggact      540

ggtggaggca caaattataa ttcagctctc aaatccagac tgagcatcag caaagacaac      600

tccaagagtc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccaggtac      660

tactgtgcca gagggggatt acgacggggg gactactttg actactgggg ccaaggcacc      720

actctcacag tctcctca                                                    738


