                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       MUNITZ, Ariel
       BENHAR, Itai
       KARO-ATAR, Danielle
       BITTON, Almog
 
<120>  TARGETING IL-13 RECEPTOR ALPHA 1 IN ATOPIC DERMATITIS AND 
       ALLERGIC DISEASES

<130>  85343

<150>  US 62/945,163
<151>  2019-12-08

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  1

Gly Gly Thr Thr Ala Cys Thr Cys Ala Thr Thr Cys Ala Cys Thr Gly 
1               5                   10                  15      


Gly Cys Thr Ala Cys Thr Ala Cys 
            20                  


<210>  2
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  2

Ala Thr Thr Ala Ala Thr Thr Cys Thr Ala Ala Cys Ala Cys Thr Gly 
1               5                   10                  15      


Gly Thr Gly Gly Thr Ala Cys Thr 
            20                  


<210>  3
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  3

Gly Cys Ala Thr Cys Thr Ala Cys Gly Gly Thr Ala Gly Thr Ala Gly 
1               5                   10                  15      


Ala Cys Thr Gly Gly Thr Thr Cys Thr Thr Cys Gly Ala Thr Gly Thr 
            20                  25                  30          


Cys 
    


<210>  4
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  4

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  5

Ile Asn Ser Asn Thr Gly Gly Thr 
1               5               


<210>  6
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  6

Ala Ser Thr Val Val Asp Trp Phe Phe Asp Val 
1               5                   10      


<210>  7
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  7

Gly Cys Thr Ala Cys Thr Ala Cys Ala Thr Gly Ala Ala Cys 
1               5                   10                  


<210>  8
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  8

Gly Ala Gly Ala Thr Thr Ala Ala Thr Thr Cys Thr Ala Ala Cys Ala 
1               5                   10                  15      


Cys Thr Gly Gly Thr Gly Gly Thr Ala Cys Thr Thr Cys Cys Thr Ala 
            20                  25                  30          


Cys Ala Ala Cys Cys Ala Gly Ala Ala Ala Thr Thr Cys Ala Ala Gly 
        35                  40                  45              


Gly Cys Cys 
    50      


<210>  9
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  9

Ala Cys Gly Gly Thr Ala Gly Thr Ala Gly Ala Cys Thr Gly Gly Thr 
1               5                   10                  15      


Thr Cys Thr Thr Cys Gly Ala Thr Gly Thr Cys 
            20                  25          


<210>  10
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  10

Gly Tyr Tyr Met Asn 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  11

Glu Ile Asn Ser Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  12

Thr Val Val Asp Trp Phe Phe Asp Val 
1               5                   


<210>  13
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  13

Cys Ala Gly Gly Ala Ala Ala Thr Thr Ala Ala Thr Gly Gly Thr Thr 
1               5                   10                  15      


Ala Cys 
        


<210>  14
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  14

Gly Cys Cys Gly Cys Gly Thr Cys Cys 
1               5                   


<210>  15
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  15

Cys Thr Gly Cys Ala Ala Thr Ala Thr Gly Cys Thr Ala Gly Thr Thr 
1               5                   10                  15      


Ala Thr Cys Cys Gly Thr Thr Cys Ala Cys Ala 
            20                  25          


<210>  16
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  16

Gln Glu Ile Asn Gly Tyr 
1               5       


<210>  17
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  17

Ala Ala Ser 
1           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  18

Leu Gln Tyr Ala Ser Tyr Pro Phe Thr 
1               5                   


<210>  19
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  19

Cys Gly Gly Gly Cys Ala Ala Gly Thr Cys Ala Gly Gly Ala Ala Ala 
1               5                   10                  15      


Thr Thr Ala Ala Thr Gly Gly Thr Thr Ala Cys Thr Thr Ala Ala Gly 
            20                  25                  30          


Cys 
    


<210>  20
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  20

Gly Cys Cys Gly Cys Gly Thr Cys Cys Ala Cys Thr Thr Thr Ala Gly 
1               5                   10                  15      


Ala Thr Thr Cys Thr 
            20      


<210>  21
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  21

Cys Thr Gly Cys Ala Ala Thr Ala Thr Gly Cys Thr Ala Gly Thr Thr 
1               5                   10                  15      


Ala Thr Cys Cys Gly Thr Thr Cys Ala Cys Ala 
            20                  25          


<210>  22
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  22

Arg Ala Ser Gln Glu Ile Asn Gly Tyr Leu Ser 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  23

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  24

Leu Gln Tyr Ala Ser Tyr Pro Phe Thr 
1               5                   


<210>  25
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  25

Gly Gly Cys Thr Ala Cys Ala Cys Cys Thr Thr Cys Ala Cys Ala Ala 
1               5                   10                  15      


Ala Cys Thr Ala Thr Gly Gly Thr 
            20                  


<210>  26
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  26

Ala Thr Thr Thr Ala Thr Cys Cys Thr Ala Gly Ala Ala Gly Thr Gly 
1               5                   10                  15      


Gly Thr Thr Ala Thr Ala Cys Thr 
            20                  


<210>  27
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  27

Gly Cys Ala Ala Gly Ala Thr Ala Thr Gly Gly Gly Gly Ala Gly Gly 
1               5                   10                  15      


Ala Thr Thr Ala Cys Thr Ala Thr Cys Cys Thr Ala Thr Gly Gly Ala 
            20                  25                  30          


Cys Thr Ala Cys 
        35      


<210>  28
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide comprising a binding domain which binds specifically 
       to human Interleukin 13 receptor

<400>  28

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide comprising a binding domain which binds specifically 
       to human Interleukin 13 receptor

<400>  29

Ile Tyr Pro Arg Ser Gly Tyr Thr 
1               5               


<210>  30
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide comprising a binding domain which binds specifically 
       to human Interleukin 13 receptor

<400>  30

Ala Arg Tyr Gly Glu Asp Tyr Tyr Pro Met Asp Tyr 
1               5                   10          


<210>  31
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  31

Ala Ala Cys Thr Ala Thr Gly Gly Thr Ala Thr Ala Ala Ala Cys 
1               5                   10                  15  


<210>  32
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  32

Gly Ala Gly Ala Thr Thr Thr Ala Thr Cys Cys Thr Ala Gly Ala Ala 
1               5                   10                  15      


Gly Thr Gly Gly Thr Thr Ala Thr Ala Cys Thr Thr Ala Cys Thr Ala 
            20                  25                  30          


Cys Ala Ala Thr Gly Ala Gly Ala Gly Gly Thr Thr Cys Ala Ala Gly 
        35                  40                  45              


Gly Gly Cys 
    50      


<210>  33
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  33

Thr Ala Thr Gly Gly Gly Gly Ala Gly Gly Ala Thr Thr Ala Cys Thr 
1               5                   10                  15      


Ala Thr Cys Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys 
            20                  25                  30  


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide comprising a binding domain which binds specifically 
       to human Interleukin 13 receptor

<400>  34

Asn Tyr Gly Ile Asn 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide comprising a binding domain which binds specifically 
       to human Interleukin 13 receptor

<400>  35

Glu Ile Tyr Pro Arg Ser Gly Tyr Thr Tyr Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide comprising a binding domain which binds specifically 
       to human Interleukin 13 receptor

<400>  36

Tyr Gly Glu Asp Tyr Tyr Pro Met Asp Tyr 
1               5                   10  


<210>  37
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  37

Ala Gly Cys Thr Cys Cys Ala Ala Cys Ala Thr Thr Gly Gly Gly Ala 
1               5                   10                  15      


Gly Thr Ala Ala Thr Thr Ala Thr 
            20                  


<210>  38
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  38

Gly Gly Thr Ala Ala Thr Gly Ala Thr 
1               5                   


<210>  39
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  39

Gly Gly Ala Ala Cys Ala Thr Gly Gly Gly Ala Thr Ala Gly Cys Ala 
1               5                   10                  15      


Gly Cys Cys Thr Gly Ala Gly Thr Gly Cys Thr Gly Gly Gly Gly Thr 
            20                  25                  30          


Ala 
    


<210>  40
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  40

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  41
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  41

Gly Asn Asp 
1           


<210>  42
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  42

Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 
1               5                   10      


<210>  43
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  43

Thr Cys Thr Gly Gly Ala Ala Gly Cys Ala Gly Cys Thr Cys Cys Ala 
1               5                   10                  15      


Ala Cys Ala Thr Thr Gly Gly Gly Ala Gly Thr Ala Ala Thr Thr Ala 
            20                  25                  30          


Thr Gly Thr Ala Thr Cys Cys 
        35                  


<210>  44
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  44

Gly Gly Thr Ala Ala Thr Gly Ala Thr Cys Ala Gly Cys Gly Gly Cys 
1               5                   10                  15      


Cys Cys Thr Cys Ala 
            20      


<210>  45
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  45

Gly Gly Ala Ala Cys Ala Thr Gly Gly Gly Ala Thr Ala Gly Cys Ala 
1               5                   10                  15      


Gly Cys Cys Thr Gly Ala Gly Thr Gly Cys Thr Gly Gly Gly Gly Thr 
            20                  25                  30          


Ala 
    


<210>  46
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  46

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 
1               5                   10              


<210>  47
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  47

Gly Asn Asp Gln Arg Pro Ser 
1               5           


<210>  48
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity-determining region (CDR) amino acid sequence

<400>  48

Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 
1               5                   10      


<210>  49
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable domains DNA sequences of anti-IL-13Ra1 binding 
       antibodies

<400>  49
gaggttcagc tgcaacaatc tggacctgag ctggtgaagc ctgggacttc agtgaagatt       60

tcctgcaagg cttctggtta ctcattcact ggctactaca tgaactgggt gaagcaaagt      120

cctgaaaaga gccttgagtg gattggagag attaattcta acactggtgg tacttcctac      180

aaccagaaat tcaaggccaa ggccacattg actgtagaca aatcctccag cacagtctac      240

atgcaactca agagcctgac atctgaggac tctgcagtct attactgtgc atctacggta      300

gtagactggt tcttcgatgt ctggggcaca gggacctctc tcacagtctc ctcg            354


<210>  50
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable domains DNA sequences of anti-IL-13Ra1 binding 
       antibodies

<400>  50
gacatccaga tgacacagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggaaattaat ggttacttaa gctggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacgcc gcgtccactt tagattctgg tgtccccaaa      180

aggttcagtg gcagtaggtc tgggtcacat tattctctca ccatcagcgg cctcgagtct      240

gaagattttg cagactatta ctgtctgcaa tatgctagtt atccgttcac attcggaggg      300

gggacaaagc tggaaataaa acgg                                             324


<210>  51
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable domains DNA sequences of anti-IL-13Ra1 binding 
       antibodies

<400>  51
gaggttcagc tgcagcaatc tggagctgag ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcaca aactatggta taaactgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag atttatccta gaagtggtta tacttactac      180

aatgagaggt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac      240

atggacctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagatatggg      300

gaggattact atcctatgga ctactggggt caaggaacca ctctcaccgt ctcctcg         357


<210>  52
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable domains DNA sequences of anti-IL-13Ra1 binding 
       antibodies

<400>  52
cagtccgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacattggg agtaattatg tatcctggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatttat ggtaatgatc agcggccctc aggggtctct      180

gaccggttct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgcgga acatgggata gcagcctgag tgctggggta      300

ttcggcggag gcaccaaggt gaccgtcctc                                       330


<210>  53
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable domains amino acid sequences of anti- IL-13Ra1 binding 
       clones

<400>  53

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Ser Asn Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Val Val Asp Trp Phe Phe Asp Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Ser Leu Thr Val Ser Ser 
        115             


<210>  54
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable domains amino acid sequences of anti- IL-13Ra1 binding 
       clones

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Asn Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser His Tyr Ser Leu Thr Ile Ser Gly Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  55
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable domains amino acid sequences of anti- IL-13Ra1 binding 
       clones

<400>  55

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Tyr Thr Tyr Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Gly Glu Asp Tyr Tyr Pro Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  56
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable domains amino acid sequences of anti- IL-13Ra1 binding 
       clones

<400>  56

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asp Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  57
<211>  972
<212>  DNA
<213>  Mus musculus

<400>  57
gcaaagacca cgcctcccag cgtgtatccc ctcgcaccag gctccgccgc ccagaccaac       60

agcatggtca cattgggctg cctcgtgaag ggctattttc cagaaccggt taccgtgacc      120

tggaactccg gctccctgag cagcggcgtc cacacgttcc cggcagtctt ggaaagcgat      180

ctgtacacac tgtcatcctc agttaccgtg cccagctcac cacgaccctc agagaccgtg      240

acctgcaacg tcgcccatcc agcctcaagc acaaaagtag ataagaagat cgtacccagg      300

gattgtggct gcaagccctg catatgtaca gtccccgaag tttcctcagt ttttatcttt      360

cccccgaagc ccaaagatgt gctgactatc acgctgacgc ccaaagtcac gtgcgttgtg      420

gtcgacataa gcaaggacga tccagaagtg caattcagtt ggtttgtcga tgatgtggaa      480

gtgcacaccg cccaaactca gccccgcgag gagcagttca actccacttt taggagcgtg      540

tccgaactgc ctatcatgca tcaggactgg cttaacggaa aagaattcaa gtgtagagtg      600

aactccgcag cgttcccagc tcccatcgaa aagacaatca gcaagactaa gggcaggcct      660

aaggccccac aggtatatac cattccccct ccaaaggaac agatggccaa ggataaagtg      720

agtcttactt gtatgatcac tgatttcttt cctgaggaca tcaccgtgga gtggcagtgg      780

aacggccagc ccgcggaaaa ctacaagaac acccagccta tcatgaatac gaatggctct      840

tatttcgtat atagtaagct gaatgtacag aaatctaact gggaggctgg taacactttt      900

acatgctcag ttctgcacga aggtctgcac aatcatcata ctgaaaaatc cctcagccac      960

agccccggga aa                                                          972


<210>  58
<211>  324
<212>  PRT
<213>  Mus musculus

<400>  58

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Glu Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  59
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  59
gctgatgcag ccccgacggt cagtatcttc cctccctcaa gcgaacaact gactagtggt       60

ggggcttcag ttgtctgctt ccttaataat ttttatccga aggacatcaa tgtcaagtgg      120

aaaattgacg gtagcgaacg acagaatggg gtgctgaact catggacgga ccaagattca      180

aaagactcca catatagtat gtctagcact cttactctca cgaaagacga gtatgaacgg      240

cacaatagct acacttgtga agccactcac aagacttcta catcccctat cgtaaagtcc      300

ttcaacagga atgaatgc                                                    318


<210>  60
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  60

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
1               5                   10                  15      


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
        35                  40                  45              


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
65                  70                  75                  80  


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
                85                  90                  95      


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105     


<210>  61
<211>  990
<212>  DNA
<213>  homo sapiens

<400>  61
gcaagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgttg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccgagg tcgacaagaa agttgagccc      300

aaatcttgcg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac acctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa                                       990


<210>  62
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  62

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Leu Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Glu Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  63
<211>  318
<212>  DNA
<213>  homo sapiens

<400>  63
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgttct                                                    318


<210>  64
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  65
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


