                         SEQUENCE LISTING

<110>  ILTOO PHARMA et al
 
<120>  interleukin 2 chimeric constructs

<130>  B3164EP

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  3
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Phe Phe Trp Cys Ala Cys Cys Leu Met Val Ala Trp Arg Val Ser 
1               5                   10                  15      


Ala Ser Asp Ala Glu His Cys Pro Glu Leu Pro Pro Val Asp Asn Ser 
            20                  25                  30          


Ile Phe Val Ala Lys Glu Val Glu Gly Gln Ile Leu Gly Thr Tyr Val 
        35                  40                  45              


Cys Ile Lys Gly Tyr His Leu Val Gly Lys Lys Thr Leu Phe Cys Asn 
    50                  55                  60                  


Ala Ser Lys Glu Trp Asp Asn Thr Thr Thr Glu Cys Arg Leu Gly His 
65                  70                  75                  80  


Cys Pro Asp Pro Val Leu Val Asn Gly Glu Phe Ser Ser Ser Gly Pro 
                85                  90                  95      


Val Asn Val Ser Asp Lys Ile Thr Phe Met Cys Asn Asp His Tyr Ile 
            100                 105                 110         


Leu Lys Gly Ser Asn Arg Ser Gln Cys Leu Glu Asp His Thr Trp Ala 
        115                 120                 125             


Pro Pro Phe Pro Ile Cys Lys Ser Arg Asp Cys Asp Pro Pro Gly Asn 
    130                 135                 140                 


Pro Val His Gly Tyr Phe Glu Gly Asn Asn Phe Thr Leu Gly Ser Thr 
145                 150                 155                 160 


Ile Ser Tyr Tyr Cys Glu Asp Arg Tyr Tyr Leu Val Gly Val Gln Glu 
                165                 170                 175     


Gln Gln Cys Val Asp Gly Glu Trp Ser Ser Ala Leu Pro Val Cys Lys 
            180                 185                 190         


Leu Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala Leu Leu Ala 
        195                 200                 205             


Phe Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn Phe Met Gln 
    210                 215                 220                 


Gln Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys Tyr Ser Leu 
225                 230                 235                 240 


Glu Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
                245                 250         


<210>  4
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala Leu Leu Ala Phe 
1               5                   10                  15      


Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn Phe Met Gln Gln 
            20                  25                  30          


Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys Tyr Ser Leu Glu 
        35                  40                  45              


Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
    50                  55                  


<210>  5
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Asp Cys Asp Pro Pro Gly Asn Pro Val His Gly Tyr Phe Glu Gly 
1               5                   10                  15      


Asn Asn Phe Thr Leu Gly Ser Thr Ile Ser Tyr Tyr Cys Glu Asp Arg 
            20                  25                  30          


Tyr Tyr Leu Val Gly Val Gln Glu Gln Gln Cys Val Asp Gly Glu Trp 
        35                  40                  45              


Ser Ser Ala Leu Pro Val Cys Lys Leu Ile Gln Glu Ala Pro Lys Pro 
    50                  55                  60                  


Glu Cys Glu Lys Ala Leu Leu Ala Phe Gln Glu Ser Lys Asn Leu Cys 
65                  70                  75                  80  


Glu Ala Met Glu Asn Phe Met Gln Gln Leu Lys Glu Ser Gly Met Thr 
                85                  90                  95      


Met Glu Glu Leu Lys Tyr Ser Leu Glu Leu Lys Lys Ala Glu Leu Lys 
            100                 105                 110         


Ala Lys Leu Leu 
        115     


<210>  6
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hi2cb fusion protein

<400>  6

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Glu Ala Pro Lys Pro Glu 
                165                 170                 175     


Cys Glu Lys Ala Leu Leu Ala Phe Gln Glu Ser Lys Asn Leu Cys Glu 
            180                 185                 190         


Ala Met Glu Asn Phe Met Gln Gln Leu Lys Glu Ser Gly Met Thr Met 
        195                 200                 205             


Glu Glu Leu Lys Tyr Ser Leu Glu Leu Lys Lys Ala Glu Leu Lys Ala 
    210                 215                 220                 


Lys Leu Leu 
225         


<210>  7
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hi2mcb fusion protein

<400>  7

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Glu Ala Pro Lys Pro Glu 
                165                 170                 175     


Cys Glu Lys Ala Leu Leu Ala Phe Gln Glu Ser Lys Asn Leu Cys Glu 
            180                 185                 190         


Ala Met Glu Asn Phe Met Gln Gln Leu Lys Glu Ser Gly Met Thr Met 
        195                 200                 205             


Glu Glu Leu Lys Tyr Ser Leu Glu Leu Lys Lys Ala Glu Leu Lys Ala 
    210                 215                 220                 


Lys Leu Leu 
225         


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker repeat

<400>  8

Gly Gly Gly Gly Ser 
1               5   


<210>  9
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hi2cb mature

<400>  9

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala 
145                 150                 155                 160 


Leu Leu Ala Phe Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn 
                165                 170                 175     


Phe Met Gln Gln Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys 
            180                 185                 190         


Tyr Ser Leu Glu Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
        195                 200                 205         


<210>  10
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hi2mcb mature

<400>  10

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Ile Gln Glu Ala Pro Lys Pro Glu Cys Glu Lys Ala 
145                 150                 155                 160 


Leu Leu Ala Phe Gln Glu Ser Lys Asn Leu Cys Glu Ala Met Glu Asn 
                165                 170                 175     


Phe Met Gln Gln Leu Lys Glu Ser Gly Met Thr Met Glu Glu Leu Lys 
            180                 185                 190         


Tyr Ser Leu Glu Leu Lys Lys Ala Glu Leu Lys Ala Lys Leu Leu 
        195                 200                 205         


