                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  NOVEL INSULIN ANALOGUES AND USES THEREOF

<130>  190084WO01

<150>  EP19215315.3
<151>  2019-12-11

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain of analogue [A9E] of human insulin of Example 1, 2, 3 and
       4

<400>  3

Gly Ile Val Glu Gln Cys Cys Thr Glu Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-chain analogue [B3E, B26E, desB30] of human insulin of example 
       1

<400>  4

Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Glu Thr Pro Lys 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-chain analogue [B3E, B27E, B28E, desB30] of human insulin of 
       example 2

<400>  5

Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Glu Glu Lys 
            20                  25                  


<210>  6
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-chain analogue [B3E, B26E] of human insulin of example 3

<400>  6

Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Glu Thr Pro Lys Thr 
            20                  25                  30  


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-chain analogue [B3E, B27E, B28E] of human insulin of example 4

<400>  7

Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Glu Glu Lys Thr 
            20                  25                  30  


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain of analogue [A9D] of human insulin of Example 5

<400>  8

Gly Ile Val Glu Gln Cys Cys Thr Asp Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A chain of analogue [A9E, A21A] of human insulin of Example 6

<400>  9

Gly Ile Val Glu Gln Cys Cys Thr Glu Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Ala 
            20      


