                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
 
<120>  NEW ANTIBODY BLOCKING HUMAN FcgammaRIIIA AND FcgammaRIIIB

<130>  B378867PCT D39791

<150>  EP19306617.2
<151>  2019-12-10

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  mus musculus

<400>  1

Gln Asp Ile Ile Lys Asn 
1               5       


<210>  2
<211>  3
<212>  PRT
<213>  mus musculus

<400>  2

Tyr Ala Thr 
1           


<210>  3
<211>  9
<212>  PRT
<213>  mus musculus

<400>  3

Leu Gln Phe Tyr Glu Phe Pro Tyr Thr 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  mus musculus

<400>  4

Gly Tyr Thr Phe Ile Arg Asn Trp 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  mus musculus

<400>  5

Ile Asp Pro Ser Asp Gly Glu Ser 
1               5               


<210>  6
<211>  16
<212>  PRT
<213>  mus musculus

<400>  6

Thr Arg Ser Arg Tyr Tyr Gly Gly Asp Trp Asp Trp Tyr Phe Asp Val 
1               5                   10                  15      


<210>  7
<211>  107
<212>  PRT
<213>  mus musculus

<400>  7

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Ile Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile Ile Lys Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Glu Val Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Phe Tyr Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  123
<212>  PRT
<213>  mus musculus

<400>  8

Gly Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Pro Ser Gly Tyr Thr Phe Ile Arg Asn 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Ser Asp Gly Glu Ser His Tyr Asn His Lys Phe 
    50                  55                  60                  


Thr Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Arg Tyr Tyr Gly Gly Asp Trp Asp Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  9
<211>  321
<212>  DNA
<213>  mus musculus

<400>  9
gacattgtgc tgacccagtc tccatcctct atatctgcat ctctgggaga cagaataacc       60

atcacttgcc aggcaactca agacattatt aagaatttga attggtatca gcagaaacca      120

gggaaacccc cttcattcct gatctattat gcaactgaag tggcagaagg ggtcccatca      180

aggttcagtg gcagtgggtc tgggtcagac tattctctga caatcagcaa cctggagtct      240

gaagattttg cagactatta ctgtctacag ttttatgagt ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  10
<211>  369
<212>  DNA
<213>  mus musculus

<400>  10
ggggtgcagc tgcaggagtc tggggctgaa ctggtgaggc ctgggtcttc agtgaaactg       60

tcctgcaagc cttctggcta caccttcatc agaaattgga tacattgggt gaagcagagg      120

cctatccaag gccttgaatg gattggtgcc attgaccctt ctgatggtga atctcactac      180

aatcacaaat tcacggacaa ggccacattg actgtagaca agtcctccag cacaggctac      240

atgcaactca acagcctgac atctgaggac tctgcggtct actactgtac aagatcgaga      300

tactacggtg gtgactggga ctggtacttc gatgtctggg gcacagggac cacggtcacc      360

gtctcctca                                                              369


<210>  11
<211>  233
<212>  PRT
<213>  artificial

<220>
<223>  aminoacid sequence of the light chain of chimeric antibody 3G4

<400>  11

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Ile Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Ile Thr Ile Thr Cys Gln Ala Thr Gln Asp Ile 
        35                  40                  45              


Ile Lys Asn Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Ser 
    50                  55                  60                  


Phe Leu Ile Tyr Tyr Ala Thr Glu Val Ala Glu Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Phe Tyr Glu 
            100                 105                 110         


Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  12
<211>  472
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of the heavy chain of chimeric 3G4

<400>  12

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Leu Ser Cys Lys Pro Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ile Arg Asn Trp Ile His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Asp Pro Ser Asp Gly Glu Ser His Tyr Asn 
65                  70                  75                  80  


His Lys Phe Thr Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Gly Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser Arg Tyr Tyr Gly Gly Asp Trp Asp Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  13
<211>  702
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence encoding the light chain of chimeric 3G4

<400>  13
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgat       60

attgtcctca ctcaaagtcc ctcctcaatt agcgcctctc ttggcgatag gataaccatc      120

acatgccaag ctactcagga catcatcaag aacctgaact ggtatcagca gaaacctggc      180

aaaccaccga gcttcctcat ctactatgcg acagaagtgg cagaaggggt tcctagcaga      240

ttctctgggt ctggatcagg cagtgactat tccctgacca tatccaatct ggaaagcgag      300

gattttgccg actactactg tctgcagttc tacgagtttc cctatacgtt tggtggtgga      360

accaagttgg agattaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  14
<211>  1419
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence encoding the heavy chain of chimeric 3G4

<400>  14
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgag       60

gtgcaactgc aggaaagtgg agcagaactc gttcgacctg gttcctcagt gaaactgagc      120

tgtaagccat ctgggtatac cttcatccgc aattggatcc attgggtcaa acagaggccc      180

atacagggac ttgagtggat tggagccatt gatccgtctg atggggaaag ccactacaac      240

cacaagttta cggacaaagc caccttgacc gtggataagt cctccagcac aggctatatg      300

cagctgaaca gcctgacaag tgaggactct gctgtgtact actgcaccag atcacggtat      360

tatggcggcg attgggactg gtacttcgac gtttggggta ctgggactac tgtcacagta      420

tccagcgcgt cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga acctgtgacg      540

gtctcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtccccg ggtaaatga                            1419


<210>  15
<211>  472
<212>  PRT
<213>  artificial

<220>
<223>  Heavy chain of chimeric 3G4 N297A

Amino acid sequence

<400>  15

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Leu Ser Cys Lys Pro Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ile Arg Asn Trp Ile His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ala Ile Asp Pro Ser Asp Gly Glu Ser His Tyr Asn 
65                  70                  75                  80  


His Lys Phe Thr Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Gly Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser Arg Tyr Tyr Gly Gly Asp Trp Asp Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  16
<211>  1419
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence encoding the heavy chain of chimeric 3G4 N297A

<400>  16
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattccgag       60

gtgcaactgc aggaaagtgg agcagaactc gttcgacctg gttcctcagt gaaactgagc      120

tgtaagccat ctgggtatac cttcatccgc aattggatcc attgggtcaa acagaggccc      180

atacagggac ttgagtggat tggagccatt gatccgtctg atggggaaag ccactacaac      240

cacaagttta cggacaaagc caccttgacc gtggataagt cctccagcac aggctatatg      300

cagctgaaca gcctgacaag tgaggactct gctgtgtact actgcaccag atcacggtat      360

tatggcggcg attgggactg gtacttcgac gtttggggta ctgggactac tgtcacagta      420

tccagcgcgt cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga acctgtgacg      540

gtctcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacgccagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtccccg ggtaaatga                            1419


<210>  17
<211>  236
<212>  PRT
<213>  artificial

<220>
<223>  Amino Acid sequence of Fc RIIIA F158

<400>  17

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp 
    210                 215                 220                 


His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
225                 230                 235     


<210>  18
<211>  236
<212>  PRT
<213>  artificial

<220>
<223>  Amino Acid sequence of Fc RIIIA V158

<400>  18

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp 
    210                 215                 220                 


His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
225                 230                 235     


<210>  19
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence of Fc RIIIB NA1

<400>  19

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Asn Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Val Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile 
    210                 215 


<210>  20
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  Amino acid sequence of Fc RIIIB NA2

<400>  20

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asn 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile 
    210                 215 


<210>  21
<211>  215
<212>  PRT
<213>  artificial

<220>
<223>  Amino Acid sequence of Fc RIIIB SH

<400>  21

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Asp Ala Thr Val Asn 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile 
    210                 215 


