                         SEQUENCE LISTING

<110>  Inserm
 
<120>  ANTIBODIES HAVING SPECIFICITY TO HER4 AND USES THEREOF

<130>  BIO17380 CHARDES/NC

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 mAb VH

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Ser Asp Tyr Phe Gly Gly Gly Met Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 mAb H-CDR1

<400>  2

Gly Phe Thr Phe Ser Asn Tyr Tyr 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 mAb H-CDR2

<400>  3

Ile Ser Gly Ser Ser Arg Tyr Ile 
1               5               


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 mAb H-CDR3

<400>  4

Val Arg Ser Ser Ser Asp Tyr Phe Gly Gly Gly Met Asp Val 
1               5                   10                  


<210>  5
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 mAb VL

<400>  5

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Gly Ser 
            20                  25                  30          


Tyr Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Tyr Asp Ser Tyr Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Ser Thr Tyr Asn 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu Gly 
            100                 105                 110     


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 mAb L-CDR1

<400>  6

Ser Ser Asp Val Gly Gly Ser Tyr Tyr 
1               5                   


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 mAb L-CDR2

<400>  7

Tyr Asp Ser 
1           


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 mAb L-CDR3

<400>  8

Ser Ser Ser Thr Tyr Asn Ser Thr Arg Val 
1               5                   10  


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5 mAb VH

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Asp Gly Ser Ser Arg Tyr Ile Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Ser Asp Tyr Phe Gly Gly Gly Met Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5 mAb H-CDR1

<400>  10

Gly Phe Thr Phe Ser Asn Tyr Tyr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5 mAb H-CDR2

<400>  11

Ile Asp Gly Ser Ser Arg Tyr Ile 
1               5               


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5 mAb H-CDR3

<400>  12

Val Arg Ser Ser Ser Asp Tyr Phe Gly Gly Gly Met Asp Val 
1               5                   10                  


<210>  13
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5 mAb VL

<400>  13

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Gly Ser 
            20                  25                  30          


Ser Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Tyr Asp Ser Tyr Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Asn Thr Tyr Tyr 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu Gly 
            100                 105                 110     


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5 mAb L-CDR1

<400>  14

Ser Ser Asp Val Gly Gly Ser Ser Tyr 
1               5                   


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 16

<400>  15

Tyr Asp Ser 
1           


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D5 mAb  L-CDR3

<400>  16

Ser Ser Asn Thr Tyr Tyr Ser Thr Arg Val 
1               5                   10  


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 mAb VH

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Asn 
            20                  25                  30          


Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Arg Tyr Ile Asn Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Asp Asp Tyr Phe Gly Gly Gly Met Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 mAb H-CDR1

<400>  18

Gly Phe Thr Phe Ser Asn Asn Asp 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 mAb H-CDR2

<400>  19

Ile Ser Gly Ser Ser Arg Tyr Ile 
1               5               


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 mAb H-CDR3

<400>  20

Val Arg Ser Ser Asp Asp Tyr Phe Gly Gly Gly Met Asp Val 
1               5                   10                  


<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 mAb VL

<400>  21

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Ser Gly Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asn Asp Ser Tyr Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Asn Asn 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu Gly 
            100                 105                 110     


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 mAb L-CDR1

<400>  22

Ser Ser Asp Val Gly Gly Tyr Ser Gly 
1               5                   


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 mAb L-CDR2

<400>  23

Asn Asp Ser 
1           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F4 mAb L-CDR3

<400>  24

Ser Ser Tyr Thr Asn Asn Ser Thr Arg Val 
1               5                   10  


<210>  25
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 mAb VH

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Asn 
            20                  25                  30          


Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Asp Ile Asn Gly Ser Ser Arg Tyr Ile Tyr Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Ser Asp Asp Tyr Phe Gly Gly Gly Met Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 mAb H-CDR1

<400>  26

Gly Phe Thr Phe Ser Asn Asn Asp 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 mAb H-CDR2

<400>  27

Ile Asn Gly Ser Ser Arg Tyr Ile 
1               5               


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 mAb H-CDR3

<400>  28

Val Arg Ser Ser Asp Asp Tyr Phe Gly Gly Gly Met Asp Val 
1               5                   10                  


<210>  29
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 mAb VL

<400>  29

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Tyr Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asn Asp Ser Tyr Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Ser Thr Tyr Tyr 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Ala Val Leu Gly 
            100                 105                 110     


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 mAb L-CDR1

<400>  30

Ser Ser Asp Val Gly Gly Tyr Tyr Ser 
1               5                   


<210>  31
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 mAb L-CDR2

<400>  31

Asn Asp Ser 
1           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 mAb L-CDR3

<400>  32

Ser Ser Thr Tyr Tyr Ser Thr Arg Val 
1               5                   


<210>  33
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             


