                         б

<110>  ͲҽҩϺι˾
 
<120>  -ҩżͶż

<130>  0113-PA-025

<160>  149   

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 HFWR1 Chothia, PR001046 HFWR1 Chothia, PR004433 HFWR1 
       Chothia

<400>  1

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  2
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000184 HFWR1 Chothia

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser 
            20                  25  


<210>  3
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 HFWR1 Chothia

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  4
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000759 HFWR1 Chothia

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  5
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 HFWR1 Chothia

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  6
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004432 HFWR1 Chothia

<400>  6

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser 
            20                  25  


<210>  7
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 HCDR1 Chothia

<400>  7

Gly Leu Asn Val Ser Arg His 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000184 HCDR1 Chothia

<400>  8

Gly Phe Thr Val Ser Lys Asn 
1               5           


<210>  9
<211>  4
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 HCDR1 Chothia

<400>  9

Gly Arg Thr Phe 
1               


<210>  10
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000759 HCDR1 Chothia

<400>  10

Gly Phe Thr Phe Ser Ser Phe 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001046 HCDR1 Chothia

<400>  11

Gly Phe Thr Val Ser Asp Asn 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 HCDR1 Chothia

<400>  12

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004432 HCDR1 Chothia

<400>  13

Gly Asp Ser Val Ser Asn Asn Tyr Ala 
1               5                   


<210>  14
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004433 HCDR1 Chothia

<400>  14

Gly Phe Thr Val Ser Asp Ser 
1               5           


<210>  15
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 HFWR2 Chothia

<400>  15

Tyr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Val Ile 
            


<210>  16
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000184 HFWR2 Chothia

<400>  16

Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ser Val Val 
            


<210>  17
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 HFWR2 Chothia

<400>  17

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
1               5                   10                  15      


Ala Ala Ile 
            


<210>  18
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000759 HFWR2 Chothia

<400>  18

Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
1               5                   10                  15      


Ala Val Ile 
            


<210>  19
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001046 HFWR2 Chothia, PR004433 HFWR2 Chothia

<400>  19

Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ser Val Ile 
            


<210>  20
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 HFWR2 Chothia

<400>  20

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Val Ile 
            


<210>  21
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004432 HFWR2 Chothia

<400>  21

Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
1               5                   10                  15      


Gly Arg Thr 
            


<210>  22
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 HCDR2 Chothia

<400>  22

Tyr Ser Gly Gly Gly 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000184 HCDR2 Chothia

<400>  23

Tyr Ser Gly Gly Ser 
1               5   


<210>  24
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 HCDR2 Chothia

<400>  24

Ser Leu Ser Pro Thr Leu 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000759 HCDR2 Chothia

<400>  25

Trp Tyr Asp Gly Arg Asn 
1               5       


<210>  26
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001046 HCDR2 Chothia

<400>  26

Phe Ser Gly Gly Asn 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 HCDR2 Chothia

<400>  27

Trp Tyr Asp Gly Ser Asn 
1               5       


<210>  28
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004432 HCDR2 Chothia

<400>  28

Tyr Tyr Arg Ser Lys Trp Tyr 
1               5           


<210>  29
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004433 HCDR2 Chothia

<400>  29

Phe Ser Gly Gly Arg 
1               5   


<210>  30
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 HFWR3 Chothia

<400>  30

Ile Glu Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Asn Asn Thr Leu Tyr Leu Gln Met Arg Ser Leu Arg Thr Glu 
            20                  25                  30          


Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  31
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000184 HFWR3 Chothia

<400>  31

Lys Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  32
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 HFWR3 Chothia

<400>  32

Ala Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Thr Val Val Leu Gln Met Asn Ser Leu Lys Pro Glu 
            20                  25                  30          


Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
        35                  40      


<210>  33
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000759 HFWR3 Chothia

<400>  33

Glu Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ser Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  34
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001046 HFWR3 Chothia

<400>  34

Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  35
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 HFWR3 Chothia

<400>  35

Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Thr Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  36
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004432 HFWR3 Chothia

<400>  36

Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Arg Val Thr Pro Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  37
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004433 HFWR3 Chothia

<400>  37

Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  38
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 HCDR3 Chothia

<400>  38

Ala Ile Pro Arg Pro His Gly Ser Asp Ile 
1               5                   10  


<210>  39
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000184 HCDR3 Chothia

<400>  39

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  40
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 HCDR3 Chothia

<400>  40

Asp Arg Lys Ser Val Met Ser Ile Arg Pro Asp Tyr 
1               5                   10          


<210>  41
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000759 HCDR3 Chothia

<400>  41

Gly Arg Gly Val Leu Gly Asp Thr Arg Ala Phe Asp Ile 
1               5                   10              


<210>  42
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001046 HCDR3 Chothia, PR004433 HCDR3 Chothia

<400>  42

Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile 
1               5                   10                  


<210>  43
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 HCDR3 Chothia

<400>  43

Glu Gln Ala Arg Ser Phe Asp Leu 
1               5               


<210>  44
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004432 HCDR3 Chothia

<400>  44

Asp Asn Tyr Tyr Gly Ser Gly Ser Pro Pro Val Asp Ala Leu Asp Ile 
1               5                   10                  15      


<210>  45
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 HFWR4 Chothia, PR000184 HFWR4 Chothia, PR000759 HFWR4 
       Chothia

<400>  45

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 HFWR4 Chothia

<400>  46

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 HFWR4 Chothia

<400>  47

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  48
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 LFWR1 Chothia

<400>  48

Asp Ile Gln Leu Thr Gln Ser Pro Tyr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  49
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 LCDR1 Chothia

<400>  49

Arg Ala Ser Gln Thr Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  50
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 LFWR2 Chothia

<400>  50

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  51
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 LCDR2 Chothia

<400>  51

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  52
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 LFWR3 Chothia

<400>  52

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  53
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 LCDR3 Chothia

<400>  53

Gln Gln Tyr Lys Leu Tyr Ser Pro Met Tyr Thr 
1               5                   10      


<210>  54
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 LFWR4 Chothia

<400>  54

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  55
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 VH

<400>  55

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Asn Val Ser Arg His 
            20                  25                  30          


Tyr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Ser Gly Gly Gly Ile Glu Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Arg Ser Leu Arg Thr Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Ile Pro Arg Pro His Gly Ser Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  56
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000184 VH

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  57
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 VH

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
        35                  40                  45              


Ser Leu Ser Pro Thr Leu Ala Tyr Tyr Ala Glu Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Val Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Asp 
                85                  90                  95      


Arg Lys Ser Val Met Ser Ile Arg Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  58
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000759 VH

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Arg Asn Glu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Val Leu Gly Asp Thr Arg Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  59
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001046 VH

<400>  59

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Asn 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  60
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 VH

<400>  60

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Ala Arg Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  61
<211>  128
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004432 VH

<400>  61

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Asn Asn 
            20                  25                  30          


Tyr Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Arg Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Asn Tyr Tyr Gly Ser Gly Ser Pro Pro Val 
            100                 105                 110         


Asp Ala Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210>  62
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004433 VH

<400>  62

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  63
<211>  109
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 VL

<400>  63

Asp Ile Gln Leu Thr Gln Ser Pro Tyr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Leu Tyr Ser Pro 
                85                  90                  95      


Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  64
<211>  351
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000020 HC

<400>  64

Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Asn Val Ser Arg 
            20                  25                  30          


His Tyr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Tyr Ser Gly Gly Gly Ile Glu Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Arg Thr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ile Pro Arg Pro His Gly Ser Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     


<210>  65
<211>  351
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000184 HC

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His 
        115                 120                 125             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                165                 170                 175     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        195                 200                 205             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    210                 215                 220                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
225                 230                 235                 240 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                245                 250                 255     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            260                 265                 270         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        275                 280                 285             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    290                 295                 300                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
305                 310                 315                 320 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                325                 330                 335     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350     


<210>  66
<211>  350
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000453 HC

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
        35                  40                  45              


Ser Leu Ser Pro Thr Leu Ala Tyr Tyr Ala Glu Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Val Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Asp 
                85                  90                  95      


Arg Lys Ser Val Met Ser Ile Arg Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 


<210>  67
<211>  354
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000759 HC

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Arg Asn Glu Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Val Leu Gly Asp Thr Arg Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  68
<211>  354
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001046 HC

<400>  68

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Asn 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  69
<211>  360
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004432 HC

<400>  69

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Asn Asn 
            20                  25                  30          


Tyr Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Arg Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Asn Tyr Tyr Gly Ser Gly Ser Pro Pro Val 
            100                 105                 110         


Asp Ala Leu Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    130                 135                 140                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            180                 185                 190         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        195                 200                 205             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    210                 215                 220                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                245                 250                 255     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            260                 265                 270         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        275                 280                 285             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    290                 295                 300                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                325                 330                 335     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            340                 345                 350         


Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360 


<210>  70
<211>  354
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR004433 HC

<400>  70

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  71
<211>  478
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR002129 SCFV

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gln Ala Arg Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Tyr Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys 
    210                 215                 220                 


Leu Tyr Ser Pro Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Gly Gly Gly Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  72
<211>  232
<212>  PRT
<213>  ˣHomo sapiens

<220>
<223>   IgG1 Fc ()

<400>  72

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  73
<211>  15
<212>  PRT
<213>  ˣHomo sapiens

<220>
<223>   IgG1 

<400>  73

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  74
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. C220-X3


<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  XaaκȻ

<400>  74

Glu Pro Lys Ser Cys Xaa Xaa Xaa Cys Pro Pro Cys Pro 
1               5                   10              


<210>  75
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. C220-X4


<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  XaaκȻ

<400>  75

Glu Pro Lys Ser Cys Xaa Xaa Xaa Xaa Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  76
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. C220-X5


<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  XaaκȻ

<400>  76

Glu Pro Lys Ser Cys Xaa Xaa Xaa Xaa Xaa Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  77
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. C220-X6


<220>
<221>  misc_feature
<222>  (6)..(11)
<223>  XaaκȻ

<400>  77

Glu Pro Lys Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  78
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. C220-X7


<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  XaaκȻ

<400>  78

Glu Pro Lys Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Pro Pro Cys 
1               5                   10                  15      


Pro 
    


<210>  79
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. C220-X8


<220>
<221>  misc_feature
<222>  (6)..(13)
<223>  XaaκȻ

<400>  79

Glu Pro Lys Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  80
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. C220-X9


<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  XaaκȻ

<400>  80

Glu Pro Lys Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Pro 
1               5                   10                  15      


Pro Cys Pro 
            


<210>  81
<211>  20
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. C220-X10


<220>
<221>  misc_feature
<222>  (6)..(15)
<223>  XaaκȻ

<400>  81

Glu Pro Lys Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  82
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge3_5

<400>  82

Glu Pro Lys Ser Cys Gln Pro Arg Cys Pro Pro Cys Pro 
1               5                   10              


<210>  83
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge3_6

<400>  83

Glu Pro Lys Ser Cys Ala Gly Trp Cys Pro Pro Cys Pro 
1               5                   10              


<210>  84
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge3_18

<400>  84

Glu Pro Lys Ser Cys Asn Val Ala Cys Pro Pro Cys Pro 
1               5                   10              


<210>  85
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge4_1

<400>  85

Glu Pro Lys Ser Cys Thr Gly Lys Met Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  86
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge4_6

<400>  86

Glu Pro Lys Ser Cys Arg Asp Ala Arg Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  87
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge4_15

<400>  87

Glu Pro Lys Ser Cys Arg Gly Thr Leu Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  88
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge5_2

<400>  88

Glu Pro Lys Ser Cys Gln Ala Glu Ser Arg Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge5_12

<400>  89

Glu Pro Lys Ser Cys Lys Asp Tyr Gly Arg Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge5_13

<400>  90

Glu Pro Lys Ser Cys Ser Asp Asn His Asp Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  91
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge6_4

<400>  91

Glu Pro Lys Ser Cys Ala Pro Val Arg Pro Trp Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  92
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge6_15

<400>  92

Glu Pro Lys Ser Cys Ser Gly Pro Ser Thr Leu Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  93
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge6_18

<400>  93

Glu Pro Lys Ser Cys Ser Ala Val Pro Arg Arg Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  94
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge7_2

<400>  94

Glu Pro Lys Ser Cys Ala Val Leu Pro Glu Ile Gly Cys Pro Pro Cys 
1               5                   10                  15      


Pro 
    


<210>  95
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge7_3

<400>  95

Glu Pro Lys Ser Cys Trp Leu Tyr Ile Ser Asp Lys Cys Pro Pro Cys 
1               5                   10                  15      


Pro 
    


<210>  96
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge7_19

<400>  96

Glu Pro Lys Ser Cys Ser Tyr Leu Phe Gly Arg Val Cys Pro Pro Cys 
1               5                   10                  15      


Pro 
    


<210>  97
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge8_8

<400>  97

Glu Pro Lys Ser Cys Met Pro Arg Leu Leu Phe His Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  98
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge8_18

<400>  98

Glu Pro Lys Ser Cys Ser Ser Asp Val Val Gly Gly Arg Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  99
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge8_20

<400>  99

Glu Pro Lys Ser Cys Arg Met Thr Val Tyr Gly Ser Arg Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  100
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge9_5

<400>  100

Glu Pro Lys Ser Cys Leu Ala Leu Pro Gly Val Met Ser Pro Cys Pro 
1               5                   10                  15      


Pro Cys Pro 
            


<210>  101
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge9_7

<400>  101

Glu Pro Lys Ser Cys Ala Ser Met Asn Arg Gly Gly Gly Gly Cys Pro 
1               5                   10                  15      


Pro Cys Pro 
            


<210>  102
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge9_14

<400>  102

Glu Pro Lys Ser Cys Gly Gly Gly Pro Phe Leu Trp Leu Val Cys Pro 
1               5                   10                  15      


Pro Cys Pro 
            


<210>  103
<211>  20
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge10_3

<400>  103

Glu Pro Lys Ser Cys Gln Met Ser Val Phe Ala Arg His Phe Pro Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  104
<211>  20
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge10_5

<400>  104

Glu Pro Lys Ser Cys Ser Val Gly Arg Phe Gly Ser Met Leu Glu Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  105
<211>  20
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Hinge10_7

<400>  105

Glu Pro Lys Ser Cys Ile Thr Glu Trp Ser Val Arg Asp Leu Gln Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  106
<211>  352
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006031 

<400>  106

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Gln 
        115                 120                 125             


Pro Arg Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210>  107
<211>  352
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006032 

<400>  107

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ala 
        115                 120                 125             


Gly Trp Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210>  108
<211>  352
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006033 

<400>  108

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asn 
        115                 120                 125             


Val Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210>  109
<211>  353
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006034 

<400>  109

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Thr 
        115                 120                 125             


Gly Lys Met Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  110
<211>  353
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006035 

<400>  110

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Arg 
        115                 120                 125             


Asp Ala Arg Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  111
<211>  353
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006036 

<400>  111

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Arg 
        115                 120                 125             


Gly Thr Leu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  112
<211>  354
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006037 

<400>  112

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Gln 
        115                 120                 125             


Ala Glu Ser Arg Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  113
<211>  354
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006038 

<400>  113

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Lys 
        115                 120                 125             


Asp Tyr Gly Arg Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  114
<211>  354
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006039 

<400>  114

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ser 
        115                 120                 125             


Asp Asn His Asp Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  115
<211>  355
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006040 

<400>  115

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ala 
        115                 120                 125             


Pro Val Arg Pro Trp Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Lys 
        355 


<210>  116
<211>  355
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006041 

<400>  116

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ser 
        115                 120                 125             


Gly Pro Ser Thr Leu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Lys 
        355 


<210>  117
<211>  355
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006042 

<400>  117

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ser 
        115                 120                 125             


Ala Val Pro Arg Arg Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Lys 
        355 


<210>  118
<211>  356
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006310 

<400>  118

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ala 
        115                 120                 125             


Val Leu Pro Glu Ile Gly Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  119
<211>  356
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006311 

<400>  119

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Trp 
        115                 120                 125             


Leu Tyr Ile Ser Asp Lys Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  120
<211>  356
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006312 

<400>  120

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ser 
        115                 120                 125             


Tyr Leu Phe Gly Arg Val Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  121
<211>  357
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006313 

<400>  121

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Met 
        115                 120                 125             


Pro Arg Leu Leu Phe His Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys 
        355         


<210>  122
<211>  357
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006314 

<400>  122

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ser 
        115                 120                 125             


Ser Asp Val Val Gly Gly Arg Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys 
        355         


<210>  123
<211>  357
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006315 

<400>  123

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Arg 
        115                 120                 125             


Met Thr Val Tyr Gly Ser Arg Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys 
        355         


<210>  124
<211>  358
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006316 

<400>  124

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Leu 
        115                 120                 125             


Ala Leu Pro Gly Val Met Ser Pro Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            260                 265                 270         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         


Ser Leu Ser Pro Gly Lys 
        355             


<210>  125
<211>  358
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006317 

<400>  125

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ala 
        115                 120                 125             


Ser Met Asn Arg Gly Gly Gly Gly Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            260                 265                 270         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         


Ser Leu Ser Pro Gly Lys 
        355             


<210>  126
<211>  358
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006318 

<400>  126

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Gly 
        115                 120                 125             


Gly Gly Pro Phe Leu Trp Leu Val Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            260                 265                 270         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         


Ser Leu Ser Pro Gly Lys 
        355             


<210>  127
<211>  359
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006319 

<400>  127

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Gln 
        115                 120                 125             


Met Ser Val Phe Ala Arg His Phe Pro Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  128
<211>  359
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006320 

<400>  128

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ser 
        115                 120                 125             


Val Gly Arg Phe Gly Ser Met Leu Glu Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  129
<211>  359
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006321 

<400>  129

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys Ile 
        115                 120                 125             


Thr Glu Trp Ser Val Arg Asp Leu Gln Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  130
<211>  128
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000892 VH

<400>  130

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Trp Asn Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Leu Pro Met Ala Ser Leu Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Gly Val Met Asp Ala Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125             


<210>  131
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000892 VL

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Leu Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  132
<211>  458
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000892 HC

<400>  132

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Trp Asn Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Leu Pro Met Ala Ser Leu Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Gly Val Met Asp Ala Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  133
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000892 LC

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Leu Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  134
<211>  231
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR005744 

<400>  134

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Trp Asn Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Leu Pro Met Ala Ser Leu Arg Tyr Phe Asp Trp Leu 
            100                 105                 110         


Gly Val Met Asp Ala Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys 
225                 230     


<210>  135
<211>  568
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR005744 

<400>  135

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Leu Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly 
    210                 215                 220                 


Leu Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
225                 230                 235                 240 


Phe Thr Val Ser Asp Ser Tyr Met Thr Trp Val Arg Gln Ala Pro Gly 
                245                 250                 255     


Lys Gly Leu Glu Trp Val Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr 
            260                 265                 270         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        275                 280                 285             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    290                 295                 300                 


Ala Leu Tyr Tyr Cys Ala Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr 
305                 310                 315                 320 


Asp Val Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                325                 330                 335     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            340                 345                 350         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        355                 360                 365             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    370                 375                 380                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
385                 390                 395                 400 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                405                 410                 415     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            420                 425                 430         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        435                 440                 445             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    450                 455                 460                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
465                 470                 475                 480 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                485                 490                 495     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            500                 505                 510         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        515                 520                 525             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    530                 535                 540                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
545                 550                 555                 560 


Ser Leu Ser Leu Ser Pro Gly Lys 
                565             


<210>  136
<211>  73
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -3


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n  Ϊ a, c, gt

<400>  136
attaggtcac cgtctcctca gagcccaaat cttgtnnknn knnktgccca ccgtgcccag       60

cacctgaact cct                                                          73


<210>  137
<211>  76
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -4


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n  Ϊ a, c, gt

<400>  137
attaggtcac cgtctcctca gagcccaaat cttgtnnknn knnknnktgc ccaccgtgcc       60

cagcacctga actcct                                                       76


<210>  138
<211>  79
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -5


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  n  Ϊ a, c, gt

<400>  138
attaggtcac cgtctcctca gagcccaaat cttgtnnknn knnknnknnk tgcccaccgt       60

gcccagcacc tgaactcct                                                    79


<210>  139
<211>  82
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -6


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  n  Ϊ a, c, gt

<400>  139
attaggtcac cgtctcctca gagcccaaat cttgtnnknn knnknnknnk nnktgcccac       60

cgtgcccagc acctgaactc ct                                                82


<210>  140
<211>  85
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -7


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  n  Ϊ a, c, gt

<400>  140
attaggtcac cgtctcctca gagcccaaat cttgtnnknn knnknnknnk nnknnktgcc       60

caccgtgccc agcacctgaa ctcct                                             85


<210>  141
<211>  88
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -8


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  n  Ϊ a, c, gt

<400>  141
attaggtcac cgtctcctca gagcccaaat cttgtnnknn knnknnknnk nnknnknnkt       60

gcccaccgtg cccagcacct gaactcct                                          88


<210>  142
<211>  91
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -9


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (60)..(61)
<223>  n  Ϊ a, c, gt

<400>  142
attaggtcac cgtctcctca gagcccaaat cttgtnnknn knnknnknnk nnknnknnkn       60

nktgcccacc gtgcccagca cctgaactcc t                                      91


<210>  143
<211>  94
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  -10


<220>
<221>  misc_feature
<222>  (36)..(37)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (45)..(46)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (60)..(61)
<223>  n  Ϊ a, c, gt

<220>
<221>  misc_feature
<222>  (63)..(64)
<223>  n  Ϊ a, c, gt

<400>  143
attaggtcac cgtctcctca gagcccaaat cttgtnnknn knnknnknnk nnknnknnkn       60

nknnktgccc accgtgccca gcacctgaac tcct                                   94


<210>  144
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  

<400>  144
actcgactcg agtcccccgg gatg                                              24


<210>  145
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   IgG1  var. (GS)2-C220

<400>  145

Gly Ser Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  146
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IgG1 var. (G4S)-C220

<400>  146

Gly Gly Gly Gly Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  147
<211>  21
<212>  PRT
<213>  СMus musculus

<220>
<223>  СIgG2c

<400>  147

Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro Pro Leu Lys Glu 
1               5                   10                  15      


Cys Pro Pro Cys Ala 
            20      


<210>  148
<211>  360
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006468 

<400>  148

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Ser 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Phe Ser Gly Gly Arg Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Asp Asp Thr Arg Gly Thr Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Arg Val Pro Ile 
        115                 120                 125             


Thr Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala 
    130                 135                 140                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            180                 185                 190         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        195                 200                 205             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    210                 215                 220                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                245                 250                 255     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            260                 265                 270         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        275                 280                 285             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    290                 295                 300                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                325                 330                 335     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            340                 345                 350         


Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360 


<210>  149
<211>  356
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR006345 

<400>  149

Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Gly Gly Gly Ala Ser Glu Pro Lys Ser 
        115                 120                 125             


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


