                         б

<110>  ĴƼ޹˾
 
<120>  εDAAOøӦ

<130>  P2020TC1341

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  368
<212>  PRT
<213>  Rhodotorula gracilis

<400>  1

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Asn Trp Thr Pro Phe Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  2
<211>  372
<212>  PRT
<213>  Rhodotorula sp. JG-1b

<400>  2

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Asn Trp Thr Pro Phe Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  3
<211>  372
<212>  PRT
<213>  Rhodotorula taiwanensis

<400>  3

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Asn Trp Thr Pro Phe Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Asn Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  4
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  4

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  5
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  5

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  6
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  6

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  7
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  7

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Asp Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  8
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  8

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  9
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  9

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Trp Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  10
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  10

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Glu Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  11
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  11

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Lys Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  12
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  12

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  13
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  13

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  14
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  14

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  15
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  15

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Thr Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  16
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  16

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Gly Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  17
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  17

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Pro Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  18
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  18

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  19
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  19

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  20
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  20

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Ala Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  21
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  21

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Val Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  22
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  22

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  23
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  23

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Thr Trp Asn Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  24
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  24

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  25
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  25

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  26
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  26

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Leu Trp Asn Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  27
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  27

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  28
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  28

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Val Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  29
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  29

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Val Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  30
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  30

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Cys Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Cys Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Ser Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Tyr Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  31
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  31

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Leu Trp Asn Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  32
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  32

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Thr Trp Asn Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  33
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  33

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  34
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  34

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Met Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  35
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  35

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Leu Trp Asn Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  36
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  36

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Thr Trp Asn Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  37
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  37

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  38
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  38

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  39
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  39

Met Cys Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  40
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  40

Met Ser Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  41
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  41

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Tyr Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  42
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  42

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  43
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  43

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  44
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  44

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Thr Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  45
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  45

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  46
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  46

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Ser Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  47
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  47

Met Ser Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Tyr Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  48
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  48

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Ala Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln His Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  49
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  49

Met Cys Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Tyr Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  50
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  50

Met Cys Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Tyr Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Ala Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  51
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  51

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln His Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  52
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  52

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Tyr Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln His Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  53
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  53

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Thr Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln His Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  54
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  54

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Tyr Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Thr Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln His Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  55
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  55

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Thr Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln His Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  56
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  56

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Thr Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln His Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  57
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  57

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Val Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Thr Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Thr Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ser Gly Tyr Gln Gln His Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  58
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  58

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Asn Trp Thr Pro Lys Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Arg Cys Thr Thr Asp Ser Ser Asp Pro Asn Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  59
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  59

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Leu Trp Asn Pro Gln Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Asn Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  60
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  60

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Thr Trp Asn Pro Gln Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Asn Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  61
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  61

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Asn Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  62
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  62

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Asn Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  63
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  63

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Asn Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  64
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  64

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Asn Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  65
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  65

Met Ala Pro Ser Lys Arg Val Val Val Leu Gly Ser Gly Val Val Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Thr Leu Ala Gln Lys Gly Tyr Ser Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Thr Ala Thr Phe Asn Gln Trp Val Asp 
65                  70                  75                  80  


Leu Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Tyr 
                85                  90                  95      


Ala Gln Asp Glu Ala Gly Leu Leu Gly His Trp Tyr Gln His Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Lys Leu Glu Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Glu Gly Gly Phe Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Asp Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Asn Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Pro Thr Ile Asn Arg Ile Leu 
                245                 250                 255     


Gln His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Val Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Val Glu Arg Val Ala Phe Pro Leu Glu 
    290                 295                 300                 


Arg Gly Lys Ser Lys Leu Ser Leu Gly Thr Ala Arg Ala Asp Ser Ser 
305                 310                 315                 320 


Lys Pro Arg Arg Glu Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Ala Glu Leu 
            340                 345                 350         


Val Glu Gly Ala Ile Gly Ala Ala Pro Ala Arg Ser Ser His Arg Trp 
        355                 360                 365             


Leu Ser Lys Leu 
    370         


<210>  66
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  66

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  67
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  67

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  68
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  68

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  69
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  69

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  70
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  70

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  71
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  71

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  72
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  72

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  73
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  73

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  74
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  74

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  75
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  75

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  76
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  76

Met Gly Ser Gln Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Ser Ala Leu Ile Leu Ala Arg Lys Gly Tyr Ser Val His Ile 
            20                  25                  30          


Leu Ala Arg Asp Leu Pro Glu Asp Val Ser Ser Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Thr Leu Thr Asp Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ser Thr Phe Lys Lys Trp Val Glu 
65                  70                  75                  80  


Leu Val Pro Thr Gly His Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Gln Asn Glu Asp Gly Leu Leu Gly His Trp Tyr Lys Asp Ile Thr 
            100                 105                 110         


Pro Asn Tyr Arg Pro Leu Pro Ser Ser Glu Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val His Ala Pro Lys Tyr Cys Gln 
    130                 135                 140                 


Tyr Leu Ala Arg Glu Leu Gln Lys Leu Gly Ala Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Thr Val Thr Ser Leu Glu Gln Ala Phe Asp Gly Ala Asp Leu Val Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Ile Asp Asp Gln 
            180                 185                 190         


Ala Ala Glu Pro Ile Arg Gly Gln Thr Val Leu Val Lys Ser Pro Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Ala Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Gly Val 
225                 230                 235                 240 


Gly Asp Trp Asp Leu Ser Val Asn Pro Glu Thr Val Gln Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Thr Ile Ser Ser Asp Gly Thr Ile 
            260                 265                 270         


Glu Gly Ile Glu Val Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Ala Glu Arg Ile Val Leu Pro Leu Asp 
    290                 295                 300                 


Arg Thr Lys Ser Pro Leu Ser Leu Gly Arg Gly Ser Ala Arg Ala Ala 
305                 310                 315                 320 


Lys Glu Lys Glu Val Thr Leu Val His Ala Tyr Gly Phe Ser Ser Ala 
                325                 330                 335     


Gly Tyr Gln Gln Ser Trp Gly Ala Ala Glu Asp Val Ala Gln Leu Val 
            340                 345                 350         


Asp Glu Ala Phe Gln Arg Tyr His Gly Ala Ala Arg Glu Ser Lys Leu 
        355                 360                 365             


<210>  77
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  77

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  78
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  78

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  79
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  79

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  80
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  80

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Thr Pro Gln Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  81
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  81

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  82
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  82

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  83
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  83

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Val Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  84
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  84

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Pro Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  85
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  85

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Arg Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


<210>  86
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant DAAO

<400>  86

Met Thr Gln Asn Lys Arg Val Val Val Leu Gly Ser Gly Val Ile Gly 
1               5                   10                  15      


Leu Ser Cys Ala Leu Ala Leu Ala Gln Lys Gly Tyr Lys Val His Val 
            20                  25                  30          


Val Ala Arg Asp Leu Pro Glu Asp Thr Val Ala Gln Thr Phe Ala Ser 
        35                  40                  45              


Pro Trp Ala Gly Ala Ile Trp Asn Pro His Met Ser Lys Glu Ala Gly 
    50                  55                  60                  


Pro Arg Gln Ala Lys Trp Glu Glu Ala Thr Phe Lys Gln Trp Val Asp 
65                  70                  75                  80  


Phe Val Pro Gln Gly Leu Ala Met Trp Leu Lys Gly Thr Arg Arg Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Asp Leu Leu Gly His Trp Tyr Lys Asp Ile Val 
            100                 105                 110         


Pro Asn Tyr Arg His Leu Asn Pro Ser Asp Cys Pro Pro Gly Ala Ile 
        115                 120                 125             


Gly Val Thr Tyr Asp Thr Leu Ser Val Asn Ala Pro Lys Phe Cys Gln 
    130                 135                 140                 


Tyr Leu Gln Arg Glu Ala Gln Lys Leu Gly Val Thr Phe Glu Arg Arg 
145                 150                 155                 160 


Leu Val Thr Ser Leu Glu Gln Ile Ala Asp Gly Ala Asp Leu Ile Val 
                165                 170                 175     


Asn Ala Thr Gly Leu Gly Ala Lys Ser Ile Ala Gly Val Glu Asp Gln 
            180                 185                 190         


Glu Val Glu Pro Ile Arg Gly Gln Thr Val Leu Ile Lys Ser Asn Cys 
        195                 200                 205             


Lys Ala Cys Thr Ser Asp Ser Ser Asp Pro Lys Ser Arg Ala Tyr Ile 
    210                 215                 220                 


Ile Pro Arg Pro Gly Gly Glu Val Ile Cys Gly Gly Thr Tyr Leu Val 
225                 230                 235                 240 


Gly Asn Tyr Asp Leu Ser Val Asp Pro Ala Thr Ile Pro Arg Ile Leu 
                245                 250                 255     


Lys His Cys Leu Arg Leu Asp Pro Ser Ile Ser Thr Asp Gly Thr Leu 
            260                 265                 270         


Glu Gly Ile Glu Ile Leu Arg His Asn Val Gly Leu Arg Pro Ala Arg 
        275                 280                 285             


Arg Gly Gly Pro Arg Val Glu Leu Glu Arg Val Ser Phe Pro Leu Lys 
    290                 295                 300                 


Arg Gly Gln Ser Leu Leu Ala Leu Gly Thr Ala Lys Ala Ala Glu Gly 
305                 310                 315                 320 


Lys Ala Ser Arg Thr Val Pro Val Val His Ala Tyr Gly Phe Ser Ser 
                325                 330                 335     


Ala Gly Tyr Gln Gln Gly Trp Gly Ala Ala Leu Glu Val Arg Asp Leu 
            340                 345                 350         


Val Asp Gln Ala Ile Gly Ser Ser Ser Ser Ala Ser Ser Gly Arg Tyr 
        355                 360                 365             


Leu Ala Lys Leu 
    370         


