                         SEQUENCE LISTING

<110>  Pairwise Plants Services, Inc.
       Hummel, Aaron
       Lawit, Shai Joshua
       Nie, Jingyi
       Fraebel, Sabine
       Guffy, Sharon Leigh
 
<120>  RECRUITMENT METHODS AND COMPOUNDS, COMPOSITIONS AND SYSTEMS FOR 
       RECRUITMENT

<130>  1499.13.WO

<150>  US 62/944,976
<151>  2019-12-06

<160>  224   

<170>  PatentIn version 3.5

<210>  1
<211>  1592
<212>  DNA
<213>  Medicago truncatula

<400>  1
actgttaata atttttaaac gtcagcgcac taaaaaaacg aaaagacgga cacgtgaaaa       60

taaaaaacac acactagttt atgacgcaat actattttac ttatgatttg ggtacattag      120

acaaaaccgt gaaagagatg tatcagctat gaaacctgta tacttcaata cagagactta      180

ctcatatcgg atacgtacgc acgaagtatc atattaatta ttttaatttt taataaatat      240

tttatcggat acttatgtga tactctacat atacacaagg atatttctaa gatactttat      300

agatacgtat cctagaaaaa catgaagagt aaaaaagtga gacaatgttg taaaaattca      360

ttataaatgt atatgattca attttagata tgcatcagta taattgattc tcgatgaaac      420

acttaaaatt atatttcttg tggaagaacg tagcgagaga ggtgattcag ttagacaaca      480

ttaaataaaa ttaatgttaa gttcttttaa tgatgtttct ctcaatatca catcatatga      540

aaatgtaata tgatttataa gaaaattttt aaaaaattta ttttaataat cacatgtact      600

attttttaaa aattgtatct tttataataa tacaataata aagagtaatc agtgttaatt      660

tttcttcaaa tataagtttt attataaatc attgttaacg tatcataagt cattaccgta      720

tcgtatctta attttttttt aaaaaccgct aattcacgta cccgtattgt attgtacccg      780

cacctgtatc acaatcgatc ttagttagaa gaattgtctc gaggcggtgc aagacagcat      840

ataatagacg tggactctct tataccaaac gttgtcgtat cacaaagggt taggtaacaa      900

gtcacagttt gtccacgtgt cacgttttaa ttggaagagg tgccgttggc gtaatataac      960

agccaatcga tttttgctat aaaagcaaat caggtaaact aaacttcttc attcttttct     1020

tccccatcgc tacaaaaccg gttcctttgg aaaagagatt cattcaaacc tagcacccaa     1080

ttccgtttca aggtataatc tactttctat tcttcgatta ttttattatt attagctact     1140

atcgtttaat cgatcttttc ttttgatccg tcaaatttaa attcaattag ggttttgttc     1200

ttttctttca tctgattgaa atccttctga attgaaccgt ttacttgatt ttactgttta     1260

ttgtatgatt taatcctttg tttttcaaag acagtcttta gattgtgatt aggggttcat     1320

ataaattttt agatttggat ttttgtattg tatgattcaa aaaatacgtc ctttaattag     1380

attagtacat ggatattttt tacccgattt attgattgtc agggagaatt tgatgagcaa     1440

gtttttttga tgtctgttgt aaattgaatt gattataatt gctgatctgc tgcttccagt     1500

tttcataacc catattcttt taaccttgtt gtacacacaa tgaaaaattg gtgattgatt     1560

catttgtttt tctttgtttt ggattataca gg                                   1592


<210>  2
<211>  2000
<212>  DNA
<213>  Zea mays

<400>  2
gtcgtgcccc tctctagaga taaagagcat tgcatgtcta aagtataaaa aattaccaca       60

tatttttttg tcacacttat ttgaagtgta gtttatctat ctctatacat atatttaaac      120

ttcactctac aaataatata gtctataata ctaaaataat attagtgttt tagaggatca      180

tataaataaa ctgctagaca tggtctaaag gataattgaa tattttgaca atctacagtt      240

ttatcttttt agtgtgcatg tgatctctct gttttttttg caaatagctt gacctatata      300

atacttcatc cattttatta gtacatccat ttaggattta gggttgatgg tttctataga      360

ctaattttta gtacatccat tttattcttt ttagtctcta aattttttaa aactaaaact      420

ctattttagt tttttattta ataatttaga tataaaatga aataaaataa attgactaca      480

aataaaacaa atacccttta agaaataaaa aaactaagca aacatttttc ttgtttcgag      540

tagataatga caggctgttc aacgccgtcg acgagtctaa cggacaccaa ccagcgaacc      600

agcagcgtcg cgtcgggcca agcgaagcag acggcacggc atctctgtag ctgcctctgg      660

acccctctcg agagttccgc tccaccgttg gacttgctcc gctgtcggca tccagaaatt      720

gcgtggcgga gcggcagacg tgaggcggca cggcaggcgg cctcttcctc ctctcacggc      780

accggcagct acgggggatt cctttcccac cgctccttcg ctttcccttc ctcgcccgcc      840

gtaataaata gacaccccct ccacaccctc tttccccaac ctcgtgttcg ttcggagcgc      900

acacacacgc aaccagatct cccccaaatc cagccgtcgg cacctccgct tcaaggtacg      960

ccgctcatcc tccccccccc cctctctcta ccttctctag atcggcgatc cggtccatgg     1020

ttagggcccg gtagttctac ttctgttcat gtttgtgtta gagcaaacat gttcatgttc     1080

atgtttgtga tgatgtggtc tggttgggcg gtcgttctag atcggagtag gatactgttt     1140

caagctacct ggtggattta ttaattttgt atctgtatgt gtgtgccata catcttcata     1200

gttacgagtt taagatgatg gatggaaata tcgatctagg ataggtatac atgttgatgc     1260

gggttttact gatgcatata cagagatgct ttttttctcg cttggttgtg atgatatggt     1320

ctggttgggc ggtcgttcta gatcggagta gaatactgtt tcaaactacc tggtggattt     1380

attaaaggat aaagggtcgt tctagatcgg agtagaatac tgtttcaaac tacctggtgg     1440

atttattaaa ggatctgtat gtatgtgcct acatcttcat agttacgagt ttaagatgat     1500

ggatggaaat atcgatctag gataggtata catgttgatg cgggttttac tgatgcatat     1560

acagagatgc tttttttcgc ttggttgtga tgatgtggtc tggttgggcg gtcgttctag     1620

atcggagtag aatactgttt caaactacct ggtggattta ttaattttgt atctttatgt     1680

gtgtgccata catcttcata gttacgagtt taagatgatg gatggaaata ttgatctagg     1740

ataggtatac atgttgatgt gggttttact gatgcatata catgatggca tatgcggcat     1800

ctattcatat gctctaacct tgagtaccta tctattataa taaacaagta tgttttataa     1860

ttattttgat cttgatatac ttggatgatg gcatatgcag cagctatatg tggatttttt     1920

agccctgcct tcatacgcta tttatttgct tggtactgtt tcttttgtcc gatgctcacc     1980

ctgttgtttg gtgatacttc                                                 2000


<210>  3
<211>  4101
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  3
gacaagaagt actccattgg cctggcgatt gggacaaact cggtggggtg ggccgtgatt       60

acggatgagt acaaggttcc aagcaagaag ttcaaggtcc tcgggaacac agatcggcat      120

tcgattaaga agaatctcat tggggcgctc ctcttcgact cgggggagac agcggaggct      180

accaggctca agcggacagc caggcggcgg tacacaaggc ggaagaatcg catctgctac      240

ctccaggaga ttttctcgaa tgagatggcg aaggtggacg acagcttctt ccatcggctg      300

gaggagtcct tcctggtgga ggaggataag aagcacgaga ggcatccaat tttcgggaac      360

atcgtggacg aggttgcgta ccatgagaag taccctacaa tctaccatct gcggaagaag      420

ctggttgact ccacagacaa ggcggacctg aggctgatct acctcgctct ggcccacatg      480

attaagttcc gcgggcattt cctgatcgag ggggacctga atcccgacaa ttcggatgtg      540

gacaagctct tcatccagct ggtgcagacc tacaaccagc tgttcgagga gaatcccatc      600

aatgcgtcgg gcgttgacgc taaggccatt ctgtccgcta ggctgtcgaa gagcaggagg      660

ctggagaacc tgatcgccca gctgccaggc gagaagaaga atgggctctt cgggaatctg      720

attgcgctct ccctggggct gacaccgaac ttcaagagca atttcgatct ggctgaggac      780

gcgaagctcc agctctcgaa ggacacttac gacgatgacc tcgataacct cctcgcgcag      840

atcggggacc agtacgctga tctcttcctc gccgctaaga acctctcgga tgctatcctg      900

ctctccgaca ttctccgggt taataccgag attacaaagg ccccactgtc ggcgtccatg      960

atcaagcggt acgatgagca tcatcaggat ctcaccctgc tcaaggccct cgtgcggcag     1020

cagctgcccg agaagtacaa ggagattttc ttcgaccaga gcaagaatgg gtacgctggc     1080

tacattgacg gcggggcctc acaggaggag ttctacaagt tcatcaagcc aatcctggag     1140

aagatggatg ggacagagga gctgctggtg aagctcaacc gggaggatct gctcaggaag     1200

cagcggacgt tcgacaacgg gtcgattccc catcagatcc acctggggga gctgcacgcg     1260

atcctgcgcc ggcaggagga tttctaccct ttcctgaagg ataatcggga gaagatcgag     1320

aagattctca ccttccggat tccctactac gtcgggccac tcgcgcgggg caatagcagg     1380

ttcgcctgga tgacacggaa gagcgaggag acaatcaccc cctggaactt cgaggaggtt     1440

gtcgacaagg gggcgtccgc ccagtcattc attgagcgga tgaccaattt cgacaagaat     1500

ctgccaaatg agaaggttct cccaaagcat agcctcctct acgagtactt cactgtttac     1560

aacgagctga ccaaggtgaa gtatgtgacc gagggcatgc ggaagcccgc gttcctgtcc     1620

ggcgagcaga agaaggccat tgtggacctc ctgttcaaga ccaatcgcaa ggtcacagtc     1680

aagcagctca aggaggatta cttcaagaag atcgagtgct tcgactcggt tgagattagc     1740

ggggtggagg atcggttcaa cgcgagcctc ggcacttacc acgacctcct gaagatcatc     1800

aaggataagg acttcctcga caacgaggag aacgaggata ttctggagga catcgtgctc     1860

accctgacgc tgttcgagga tcgggagatg atcgaggagc gcctgaagac ctacgctcat     1920

ctcttcgatg ataaggtcat gaagcagctg aagaggaggc ggtacaccgg gtggggccgc     1980

ctgagcagga agctcattaa cgggatcagg gacaagcaga gcggcaagac catcctggac     2040

ttcctcaaga gcgatggctt cgccaaccgg aatttcatgc agctcatcca cgacgactcc     2100

ctcaccttca aggaggacat tcagaaggct caggtcagcg gccagggcga ctcgctgcat     2160

gagcacatcg ctaacctggc gggcagccca gccatcaaga agggcatcct ccagacagtg     2220

aaggtcgtgg atgagctggt gaaggtcatg ggccggcata agcccgagaa tattgtgatt     2280

gagatggcgc gggagaatca gaccactcag aagggccaga agaactcgcg ggagcgcatg     2340

aagaggatcg aggaggggat taaggagctg ggcagccaga ttctcaagga gcaccccgtg     2400

gagaataccc agctccagaa cgagaagctg tacctctact acctccagaa tgggcgggac     2460

atgtatgttg atcaggagct ggacatcaat cgcctctcgg attacgacgt ggaccacatc     2520

gtgccccaga gcttcctgaa ggatgatagc atcgacaata aggtcctgac ccgctccgac     2580

aagaatcgcg gcaagagcga caacgtgccg agcgaggagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgcgaagctc attacacagc ggaagttcga taacctgacg     2700

aaggcggaga ggggcggcct ctccgagctg gacaaggcgg gcttcattaa gaggcagctc     2760

gtggagactc gccagatcac caagcacgtg gctcagatcc tcgatagccg gatgaatacg     2820

aagtacgatg agaatgacaa gctcatccgg gaggtgaagg taatcaccct gaagtcaaag     2880

ctcgttagcg atttccggaa ggacttccag ttctacaagg tgcgggagat taacaactac     2940

catcatgcgc acgatgcgta cctcaatgcg gtggtgggca cagccctgat taagaagtac     3000

cccaagctgg agagcgagtt cgtctacggg gactacaagg tgtacgatgt tcggaagatg     3060

atcgccaaga gcgagcagga gattgggaag gccaccgcta agtacttctt ctactcgaat     3120

attatgaatt tcttcaagac cgagatcaca ctcgctaatg gggagattcg gaagcggccc     3180

ctcatcgaga ctaacgggga gactggcgag attgtgtggg acaaggggcg cgacttcgct     3240

accgtgcgca aggtcctctc gatgccccag gttaatattg ttaagaagac agaggtgcag     3300

acgggcgggt tctccaagga gtctatcctg ccgaagcgga actcggacaa gctgatcgcc     3360

cgcaagaagg attgggaccc caagaagtac gggggattcg atagcccaac cgtggcttac     3420

agcgtcctgg tggtcgccaa ggttgagaag gggaagtcga agaagctcaa gagcgttaag     3480

gagctgctgg gcatcaccat catggagcgg tccagcttcg agaagaatcc tatcgacttc     3540

ctggaggcta aggggtacaa ggaggtcaag aaggacctga tcattaagct gcccaagtac     3600

tctctgttcg agctggagaa cgggaggaag cggatgctgg cgtctgctgg cgagctacag     3660

aagggcaatg agctggcgct cccctcgaag tatgtcaact tcctctacct ggcttcccat     3720

tacgagaagc tgaagggctc gcccgaggat aatgagcaga agcagctctt cgtggagcag     3780

cacaagcact acctcgacga gatcattgag cagatttcgg agttctcgaa gcgggtcatt     3840

ctcgcggacg cgaacctcga caaggtcctc tcggcgtaca acaagcaccg ggacaagccc     3900

atccgggagc aggccgagaa cattatccac ctcttcacac tgaccaacct cggcgctccc     3960

gccgcgttca agtacttcga caccaccatt gaccgcaaga gatacacatc caccaaggag     4020

gtgctggacg cgaccctcat ccaccagagc atcacaggcc tctacgagac acggatcgac     4080

ctctcgcagc tcgggggcga t                                               4101


<210>  4
<211>  4092
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  4
gacaagaagt actcgatcgg cctggcgatt ggcacaaaca gcgtggggtg ggctgtgatc       60

actgatgagt acaaggtgcc atcgaagaag ttcaaggtgc tggggaatac agaccggcat      120

tcgatcaaga agaatctcat tggcgctctc ctcttcgatt ccggcgagac tgctgaggcg      180

acccgcctga agcgcaccgc ccggcggcgc tacactcggc ggaagaatag gatttgctac      240

ctccaggaga ttttctcgaa tgagatggcc aaggtggatg acagcttctt ccaccgcctg      300

gaggagtcgt tcctggtcga ggaggacaag aagcatgagc ggcaccctat cttcgggaat      360

atcgttgatg aggtcgccta ccacgagaag taccccacta tctaccatct ccgcaagaag      420

ctcgtggaca gcacagataa ggccgacctc cgcctgatct acctcgccct cgcgcacatg      480

attaagttcc gggggcactt cctcattgag ggggatctga atcccgataa ctccgacgtg      540

gacaagctgt tcatccagct ggtgcagaca tacaaccagc tgttcgagga gaatcccatc      600

aacgcgagcg gcgtggacgc taaggccatt ctgtcggcta ggctctcgaa gtcgaggcgg      660

ctggagaacc tgattgcgca gctccccggc gagaagaaga acgggctgtt cgggaatctc      720

atcgccctct ccctcggcct cacaccaaac ttcaagagca atttcgacct ggctgaggac      780

gctaagctgc aactctcaaa ggatacatac gatgacgacc tggacaatct cctggctcag      840

atcggcgacc agtacgctga cctgttcctc gcggccaaga atctgtcgga cgcgattctc      900

ctcagcgaca tcctgcgcgt caataccgag attacgaagg ctccactgtc tgcgtcaatg      960

attaagcggt acgatgagca tcaccaggat ctgaccctcc tgaaggcgct cgtgcggcag     1020

cagctgcccg agaagtacaa ggagattttc ttcgatcaga gcaagaatgg ctacgccggc     1080

tacatcgacg ggggcgcgag ccaggaggag ttctacaagt tcatcaagcc catcctggag     1140

aagatggacg gcaccgagga gctactcgtg aagctcaatc gggaggatct cctccggaag     1200

cagcggacat tcgataacgg gtctatccca caccagatcc acctcggcga gctgcatgcg     1260

attctgcggc ggcaggagga tttctaccct ttcctgaagg acaaccggga gaagatcgag     1320

aagatcctca cattccggat tccatactac gtcggccccc tggcgagggg caatagccgg     1380

ttcgcgtgga tgacaaggaa gtccgaggag actattaccc cgtggaattt cgaggaggtg     1440

gttgacaagg gcgcttccgc gcagagcttc attgagcgga tgacaaactt cgacaagaat     1500

ctccccaacg agaaggtcct gccgaagcat agcctcctgt acgagtactt caccgtctac     1560

aatgagctaa ctaaggtcaa gtatgtgaca gagggcatga ggaagccagc cttcctctca     1620

ggcgagcaga agaaggccat tgtggacctc ctgttcaaga caaaccgcaa ggtgacagtg     1680

aagcagctga aggaggatta cttcaagaag attgagtgct tcgactcagt ggagatttca     1740

ggcgtggagg atcggttcaa cgcgagcctg gggacttacc acgacctgct gaagattatt     1800

aaggacaagg acttcctgga taacgaggag aatgaggaca tcctggagga tattgtgctc     1860

accctcaccc tgttcgagga cagggagatg attgaggaga ggctcaagac ctacgcgcac     1920

ctgttcgatg acaaggtcat gaagcagctg aagaggcggc gctacactgg gtggggccgc     1980

ctgtcgcgga agctgatcaa cggcattcgg gataagcagt ccgggaagac cattctggat     2040

ttcctgaagt cggacggctt cgccaacagg aatttcatgc agctgatcca cgacgactcc     2100

ctcaccttca aggaggacat tcagaaggcc caggttagcg gccaggggga ctcactccac     2160

gagcatattg ccaatctggc cggctctcca gctatcaaga agggcatcct gcaaacagtt     2220

aaggttgttg acgagctggt taaggtcatg gggcggcata agcccgagaa cattgtcatc     2280

gagatggctc gggagaacca gacaactcag aagggccaga agaactccag ggagcgcatg     2340

aagcggattg aggagggcat taaggagctg gggtcccaga tcctcaagga gcaccctgtc     2400

gagaacactc agctgcaaaa cgagaagctc tacctgtact acctccagaa cgggcgggat     2460

atgtatgtgg atcaggagct ggacatcaac aggctctccg actacgacgt ggatcacatt     2520

gtcccacagt ctttcctcaa ggatgattcc atcgacaaca aggtgctgac gcgcagcgac     2580

aagaataggg ggaagtcgga caacgttccg agcgaggagg tcgtgaagaa gatgaagaat     2640

tactggaggc agctcctgaa tgcgaagctg atcactcaga ggaagttcga caatctgaca     2700

aaggcggaga ggggcgggct ctcggagctg gataaggcgg gcttcatcaa gcggcagctc     2760

gttgaaaccc ggcagatcac caagcatgtc gcccagatcc tcgatagccg catgaacacc     2820

aagtacgatg agaacgacaa gctcattcgg gaggttaagg tcattacgct gaagtccaag     2880

ctcgtcagcg acttcaggaa ggatttccag ttctacaagg ttcgggagat taacaactac     2940

caccacgcgc atgatgcgta cctgaacgct gttgtcggca ctgctctcat caagaagtac     3000

ccaaagctgg agtccgagtt cgtctacggg gactacaagg tctacgatgt ccggaagatg     3060

atcgccaagt cggagcagga gatcgggaag gctactgcga agtacttctt ctacagcaac     3120

attatgaatt tcttcaagac ggagattacg ctggcgaacg gggagattag gaagaggccc     3180

ctcattgaga ctaatgggga gacaggcgag attgtttggg acaagggccg cgacttcgcg     3240

actgtgcgga aggtcctgtc catgccacag gtgaatattg ttaagaagac agaggtgcag     3300

actgggggct tctcgaagga gagcattctc ccaaagcgga acagcgataa gctcatcgcg     3360

cgcaagaagg attgggaccc taagaagtac ggcggcttcg attctcccac tgtggcctac     3420

tccgttctcg tggttgccaa ggttgagaag gggaagtcga agaagctgaa gtcggtcaag     3480

gagctgctcg ggattacaat catggagcgg agcagcttcg agaagaaccc tattgatttc     3540

ctggaggcca agggctacaa ggaggttaag aaggatctca ttatcaagct ccctaagtac     3600

tctctgttcg agctggagaa tggccggaag aggatgctgg cctcggctgg cgagctacag     3660

aaggggaatg agctggccct cccgtcgaag tatgtgaatt tcctgtacct cgcgtcgcac     3720

tacgagaagc tcaagggcag cccggaggat aatgagcaga agcagctctt cgtggagcag     3780

cataagcact acctggacga gatcattgag cagatcagcg agttctcgaa gcgggttatt     3840

ctggctgatg ctaacctgga caaggttctg agcgcctaca ataagcatcg cgacaagccg     3900

attcgcgagc aggcggagaa tattatccac ctgttcaccc tcactaacct cggggctccc     3960

gcggccttca agtacttcga taccacaata gataggaagc ggtacacctc gacgaaggag     4020

gtcctcgacg ccacactcat ccatcagtcg attacaggcc tgtacgagac acggattgac     4080

ctctcgcagc tg                                                         4092


<210>  5
<211>  4101
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  5
gacaagaagt attccatagg cctggctatc ggcaccaaca gcgtgggctg ggccgtcatc       60

accgacgagt acaaagtgcc gagtaaaaag ttcaaagtgc tcggcaacac cgaccgccac      120

tccataaaga aaaacctgat cggggcgctc ctgttcgaca gcggcgagac ggcggaggcc      180

acccgcttga aacgcacggc ccgacggcgc tacacgcggc gcaagaaccg gatctgttac      240

ctacaggaga ttttctctaa cgagatggcg aaggtggacg actcgttctt tcaccgcctc      300

gaagagtcct tcctcgtgga ggaggacaag aaacacgagc gccacccgat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag tacccgacca tctaccacct ccggaagaaa      420

ctcgtggaca gcacggacaa ggccgacctg aggctcatct acctcgccct ggcgcacatg      480

attaagttcc ggggccactt cctgatcgag ggcgacctga acccggacaa cagcgacgtg      540

gacaagctgt tcatccagct agtccagacc tacaaccagc ttttcgagga aaaccccatc      600

aacgccagcg gggtggacgc gaaggcgatc ctgtccgccc ggctgagcaa gtcccggcgg      660

ctggagaacc tcatcgcgca gttgcccggc gagaagaaga acgggctgtt cgggaacctg      720

atcgccctct ccctggggct caccccgaac ttcaagtcca acttcgacct cgccgaggac      780

gccaaactac agctgagcaa ggacacctac gacgacgacc tcgacaacct gctggcccag      840

atcggggacc agtacgcaga cctgttcctc gccgccaaga acctctccga cgccatcctg      900

ctgtcggaca tcctgcgggt gaacacggag atcacgaagg ccccgctctc ggcctcgatg      960

attaaacgct acgacgagca ccaccaggac ttgaccctcc tcaaggcgct ggtccgccag     1020

cagcttcccg agaagtacaa ggaaatcttt ttcgatcaga gcaagaacgg gtacgccggg     1080

tacatcgacg gcggggcgtc ccaggaggag ttctacaagt tcatcaagcc catcctggag     1140

aaaatggacg ggaccgagga gctgctcgtg aagctcaacc gcgaagattt gctccgcaag     1200

cagcgcacgt tcgacaacgg gtcgatcccg caccagatcc acctgggcga gctgcacgcg     1260

atcctcaggc gtcaggaaga cttctacccc ttcctcaagg acaaccgcga gaagatagag     1320

aagattctga ccttcagaat tccttattac gtgggcccgc tggctcgggg caactcgcgc     1380

ttcgcctgga tgacgcgcaa gtccgaggag accatcaccc cgtggaactt cgaggaggtg     1440

gtggataagg gtgcctcggc ccagtccttc atcgagcgga tgaccaactt cgacaagaac     1500

ctgccgaacg agaaggtgct ccccaagcac agcctgctct acgaatattt cacggtgtac     1560

aacgagctga cgaaggtcaa gtacgtgacc gagggaatga ggaaacctgc attcctctcc     1620

ggggagcaga agaaagccat agtcgacctc ctgttcaaga ccaaccggaa ggtcaccgtc     1680

aagcagctca aggaggacta cttcaagaag atcgagtgct tcgattcagt ggagatcagc     1740

ggcgtcgagg accggttcaa cgccagcctg ggcacctacc acgacctgct caagatcatc     1800

aaggacaagg acttcctcga caacgaggag aacgaggaca tcctggagga catcgtgctg     1860

accctgacgc tcttcgagga ccgcgagatg atcgaggagc gcctcaagac ctacgcccac     1920

ctgttcgacg acaaggtgat gaagcagctc aagcggcgga gatatactgg gtggggccgc     1980

ctctcccgga agctcattaa cggtatcagg gataagcagt ccgggaagac gatcctcgac     2040

ttcctcaagt cggacgggtt cgccaaccgc aacttcatgc agctcatcca cgacgactcc     2100

ctgacgttca aggaggacat ccagaaggcc caagtgtctg gtcaaggtga ctcgctccac     2160

gagcacatcg ccaacctcgc gggcagcccg gccatcaaga agggaatact ccagaccgtc     2220

aaggtggtgg acgagctggt gaaggtcatg ggccgccaca agccggagaa catcgtcatc     2280

gagatggcgc gggagaacca gaccacgcag aaggggcaga aaaatagccg tgagcgcatg     2340

aagcgcatcg aggaggggat taaggagttg ggcagccaga tcctcaagga gcaccctgtg     2400

gagaacacgc agttgcaaaa cgagaagctc tacctgtact acctccagaa cgggagggat     2460

atgtacgtgg accaagaact ggacatcaac cgcctgtccg actacgacgt ggaccacatc     2520

gtgccgcaga gcttcctcaa ggacgacagc atcgacaaca aggtgctcac ccggtccgac     2580

aagaatcggg gcaagtccga caacgtgccc agcgaggagg tcgtcaaaaa gatgaaaaac     2640

tactggcgac aactactgaa cgccaagctc atcacccagc gcaagttcga caacctcaca     2700

aaagccgagc gcggcgggtt gagcgagctg gacaaggccg ggttcatcaa gcgccagctc     2760

gtcgagacgc gccagatcac gaagcacgtc gcgcagatac tcgacagccg gatgaacacc     2820

aagtacgacg agaacgacaa gctcatccgg gaggtgaagg tcatcaccct caagtcgaag     2880

ctcgtgagcg acttccgcaa ggacttccag ttctacaagg tccgggagat caacaactac     2940

caccacgccc acgatgctta tcttaacgcc gtggtgggga cggccctcat taagaaatac     3000

ccgaagctgg agtcggagtt cgtgtacggc gactacaagg tgtacgacgt caggaagatg     3060

atcgccaagt ccgaacagga gatcgggaag gccacggcga aatacttctt ctacagcaac     3120

atcatgaact tcttcaagac cgagatcacc ctcgccaacg gcgagatccg caagcgcccg     3180

ctcatcgaga cgaacgggga gaccggcgag atcgtctggg acaaggggcg cgacttcgcc     3240

actgtgcgga aggtgctgtc gatgccccag gtcaacatcg tcaagaagac ggaggtccag     3300

acgggcgggt tcagcaagga gagcatcctg ccgaagcgca acagcgacaa gctgatcgcc     3360

cgcaaaaagg actgggatcc aaaaaagtac ggcggcttcg acagccccac cgtcgcctac     3420

agcgtcctcg tcgtcgctaa agtcgagaag ggcaagtcca aaaagctcaa gagcgtcaag     3480

gagctgctcg ggatcaccat catggagcgg tccagcttcg agaagaaccc aattgatttc     3540

ctggaggcga agggctacaa ggaggtcaag aaagacctca tcataaagct gccgaagtac     3600

tcactcttcg agctggagaa cgggcgcaag cggatgctgg cgtcggccgg agagctccaa     3660

aagggcaacg agctggcgct gccgagcaag tacgtgaact tcctctacct ggcgtcccac     3720

tacgagaagc tcaagggcag tccagaggat aacgagcaga agcagctatt cgtggagcag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gcgcgtcatc     3840

ctggcggacg ccaacctgga caaggtgctg tccgcgtaca acaagcaccg cgacaagccg     3900

atccgcgagc aagccgagaa catcatccac ctgttcaccc tcacgaacct cggggcaccc     3960

gccgccttca aatatttcga cacgaccatc gaccgcaagc gctacaccag cacgaaggag     4020

gtgctcgacg ccaccctgat ccaccagagc atcaccgggc tgtacgagac ccgcatcgac     4080

ctctcgcagc tcggcgggga c                                               4101


<210>  6
<211>  4101
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  6
gacaagaagt acagtattgg attggccatc gggacgaaca gcgtgggctg ggccgtcatc       60

accgacgagt acaaggtgcc atccaagaag tttaaggttc tggggaatac cgaccgccac      120

tcgatcaaga aaaatctcat cggggcgctg cttttcgaca gcggcgagac ggcggaagcg      180

acgcggctca agcggacggc tcgtcgccgt tacacccggc gtaagaaccg catctgttac      240

ctccaggaga tattcagcaa cgagatggcg aaggtggacg actccttttt ccaccgtctt      300

gaggagtcct tcctggtcga ggaggacaag aagcacgagc gccacccgat cttcgggaac      360

atcgtggacg aggtggccta ccacgagaag taccccacga tctaccacct ccgcaaaaaa      420

ctcgtggact caactgacaa ggccgatttg aggcttatct acctcgccct cgcccacatg      480

attaagttcc gtgggcactt cctaatcgag ggtgacctca accccgacaa ctctgacgtg      540

gacaagctgt tcatccagct tgtgcagacc tacaatcagc tctttgagga gaatccgatc      600

aacgcatctg gtgtggacgc aaaggccatc ctcagcgcgc ggctgagcaa gtctaggcgg      660

ttggagaacc tgatcgccca actgcccggc gagaagaaaa atggcctctt cggcaacctg      720

atcgccctgt cgctggggct cacgccgaac ttcaagagta actttgacct ggcggaggac      780

gctaagctcc agctatctaa ggacacatac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctcttccta gccgccaaga acctgtccga cgccatcctc      900

ctcagcgaca tcctgcgcgt gaacacggag atcacgaagg ctccgctcag cgcctccatg      960

attaagcggt acgacgagca ccaccaagac ctaactttac tcaaagccct cgtgcggcag     1020

cagcttcccg agaagtacaa agagatattt tttgatcagt ccaagaacgg ttatgcgggc     1080

tacatcgacg gcggcgcgag ccaggaggag ttctacaagt tcatcaagcc catcctggag     1140

aagatggacg gcacggagga gctgctcgtg aagctcaacc gtgaagacct cctgcgaaag     1200

cagcgaacct tcgacaacgg ttcgatcccg caccagatcc acctcgggga gctgcacgcc     1260

atcctgaggc gacaggagga cttctaccct ttcctaaagg acaaccgcga gaagattgaa     1320

aaaatcctga cgtttcgcat accctactac gtcggcccgc tggcgcgcgg caactcccgg     1380

ttcgcctgga tgacccgtaa gagcgaggag acgatcaccc cgtggaactt cgaggaggtc     1440

gtggacaagg gcgcgagcgc gcagagcttc atcgagcgca tgaccaactt cgacaagaac     1500

ctcccgaacg agaaggtgct cccaaagcac tccctcctgt acgagtattt caccgtgtac     1560

aacgagttga caaaggtgaa gtacgtgacg gagggaatgc ggaagcctgc gttcctctcg     1620

ggcgagcaga agaaggcaat cgtggacctg ctcttcaaga ccaaccggaa ggtgacggtg     1680

aagcagctca aggaggacta cttcaaaaaa atcgagtgct tcgactccgt ggagataagc     1740

ggcgtggagg accgattcaa cgcctccctc ggcacctacc acgacctcct taagatcatc     1800

aaggacaagg acttcctgga caacgaggag aacgaggaca tcctggagga catcgtgctc     1860

accctgaccc tcttcgagga ccgggagatg atcgaggagc gcctcaagac gtacgcccac     1920

ttgttcgacg acaaggtgat gaagcagctc aagcggcggc gatacaccgg gtggggccgc     1980

ctatcccgca aacttatcaa cggcatccgc gacaagcagt ccggcaagac gatcctggat     2040

ttcctcaagt cggacgggtt cgccaaccgg aacttcatgc agctcatcca cgacgacagc     2100

ctcacgttca aggaggacat ccagaaggcc caagtgagcg gtcaagggga cagcctccac     2160

gagcacattg cgaaccttgc tgggagccct gcgatcaaga aggggatatt gcaaaccgtg     2220

aaggtcgtgg acgagttggt gaaggtcatg gggcgacaca agcccgagaa catcgtgatc     2280

gagatggcca gggaaaatca gaccacgcag aagggccaaa aaaacagccg cgagcggatg     2340

aagcggatcg aggagggcat caaggagctg gggtcgcaga tcctcaagga gcacccggtg     2400

gagaacacgc agctccagaa cgagaagctg tacctctatt acctacagaa cgggcgggat     2460

atgtacgtgg accaggagct agacatcaac cgcctgtccg actacgacgt ggaccatatc     2520

gtcccgcagt cgttcttgaa ggacgacagc atcgacaaca aggtgctcac aagatcggat     2580

aagaatcgag gcaagtccga caacgtgccc tcggaggagg tggtcaagaa aatgaaaaac     2640

tactggcggc agttgctgaa cgccaagctc attacgcagc ggaagttcga caacctgacg     2700

aaggctgaac gtggtgggct cagcgagcta gacaaggcgg ggttcatcaa gcggcagctc     2760

gtcgagaccc ggcagatcac caagcacgtg gcgcagatcc tggactcgcg catgaacacc     2820

aagtacgacg agaacgacaa gctcatccgt gaggtgaagg tcatcaccct taagtctaag     2880

ctggtcagtg acttccgcaa ggacttccag ttctacaagg tccgggagat caacaactac     2940

caccacgcgc acgacgccta cctcaacgcg gtggtgggga cggcgcttat taagaaatat     3000

cccaagctgg aaagcgagtt cgtttacggc gactacaagg tgtacgacgt ccgcaagatg     3060

atcgcaaagt cggaacagga aatcggaaag gcgacggcca aatatttctt ttactccaac     3120

atcatgaatt tttttaagac ggagatcacc ctggcgaacg gggagatccg caagcggccc     3180

ctcatcgaga ccaacgggga gacgggcgag atcgtctggg acaagggccg ggacttcgcc     3240

accgtgcgga aggtgctttc tatgcctcaa gtcaatatcg tcaaaaagac agaggtgcag     3300

accggcgggt tcagcaagga gtctatcctg ccgaagcgca actcggacaa gctcatcgcg     3360

cgcaagaaag actgggaccc caaaaaatat ggcgggttcg actcgccgac cgtcgcctac     3420

agcgtcctcg tggtggctaa ggtcgagaag ggcaagagca aaaagctaaa gtcggtgaag     3480

gagctgctgg gcatcaccat catggagcgc tcgtctttcg agaagaatcc aatcgacttc     3540

ctagaggcga aggggtacaa ggaggtcaaa aaggatctta tcatcaaact gccgaagtac     3600

agtctgttcg agctggagaa cgggcggaag cggatgctgg ctagtgcggg cgagttgcag     3660

aagggcaacg agttggcact gccctccaag tacgtgaact tcctgtacct ggcctcccac     3720

tacgagaagc tcaaggggag ccccgaggac aacgagcaga agcagctatt cgtcgagcag     3780

cacaagcact acctggacga gatcatcgag cagatcagtg agttctccaa gcgggtcatc     3840

ctcgcggacg ccaacctgga caaggtgctg agcgcgtaca acaagcacag ggacaagcca     3900

atcagggaac aggccgagaa catcatccac ctgttcaccc tgaccaacct gggtgcaccg     3960

gctgccttca agtactttga cacgaccatc gaccggaagc gctacacctc cacgaaggag     4020

gtgctggacg ccacgctgat ccaccagagc atcaccgggc tctacgagac acggatcgac     4080

ctgagccagc ttggcgggga c                                               4101


<210>  7
<211>  4092
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  7
gacaaaaagt attccattgg actcgctatc ggcacgaaca gcgtcgggtg ggcggtcatc       60

actgacgagt acaaggtgcc gagcaagaag tttaaggtgc tgggaaacac cgacaggcac      120

tcgatcaaga aaaatcttat cggggcccta ctcttcgact ccggagaaac cgccgaggcc      180

acccggttga agcgcacggc ccgccgtcgc tacaccaggc gcaagaaccg gatctgctac      240

ctccaggaga tattcagcaa tgagatggcg aaggtggacg actcgttttt tcacaggcta      300

gaggagtctt tcctcgtgga ggaggacaag aaacacgagc gccaccccat cttcggcaac      360

atcgtggatg aggtggcata tcacgagaag tacccaacca tctaccacct ccgcaaaaag      420

ctcgtggact ctaccgacaa ggccgacctc cgtctgatct acctcgcgct ggcccacatg      480

attaagttcc gaggacactt tctgatcgag ggcgacctga acccagacaa cagcgacgtg      540

gacaagctgt tcatccaact tgtccagacc tacaatcagc tcttcgagga gaaccctatc      600

aacgcctcgg gcgtggacgc gaaggccatc ctgtccgccc gcctgagcaa gtcgcggcgg      660

ctggagaacc tgatcgccca gctccccggc gaaaaaaaga acggcctctt cggcaacctc      720

atcgcgttgt cgctggggct caccccgaac ttcaagtcca acttcgacct ggccgaggac      780

gctaaactcc agctctcgaa ggatacctac gacgacgacc tcgacaacct gctggcccag      840

atcggcgacc agtacgcgga ccttttcctg gcggccaaga acctgagcga cgcgatcctc      900

cttagcgaca tactccgtgt gaacaccgag atcacgaagg ccccgctctc cgcgtccatg      960

attaagcgct acgacgagca ccaccaagac cttaccctgc ttaaggcgct ggtcaggcag     1020

cagttaccgg agaagtacaa ggagatcttt tttgatcaat ctaagaacgg ttacgccggg     1080

tacatcgacg gcggcgcgtc ccaggaggag ttctacaagt tcatcaagcc gatcttggag     1140

aaaatggacg ggaccgagga gctgctcgtg aagctcaacc gcgaagacct cctccgcaag     1200

cagcgcacct tcgacaacgg gagcatcccg caccagatcc acctgggaga gctgcacgcg     1260

atcctgcgga gacaagagga cttctacccc ttcctcaagg acaaccggga gaagattgaa     1320

aaaatactta cttttcgtat cccgtactac gtcgggcccc ttgcgagggg caactccaga     1380

ttcgcgtgga tgacccgcaa gtccgaggag accatcaccc cgtggaactt cgaggaggtg     1440

gtggacaagg gcgcgtcggc ccagtcgttc atcgagcgca tgaccaactt cgacaagaac     1500

cttccgaacg agaaggtgct cccgaagcac agcctgctct acgaatattt tactgtgtac     1560

aacgagctga cgaaggtcaa gtacgttacg gaggggatga ggaagcccgc cttcctctcc     1620

ggcgagcaga agaaagccat tgtggatctc ctgttcaaga ccaaccgcaa ggtgacggtg     1680

aaacagctca aagaggacta cttcaagaag atcgagtgct tcgactccgt agagatcagc     1740

ggggtcgagg accgcttcaa cgcctcgctg ggcacgtacc acgacctgct aaagattatc     1800

aaggacaaag acttcctaga caatgaggag aacgaggaca ttctggagga catcgtgctg     1860

actctgacgc tgttcgaaga ccgcgagatg atcgaggagc ggcttaagac gtacgcccac     1920

ctgttcgacg acaaggtgat gaagcagttg aaacggcggc gctacaccgg gtggggccgc     1980

ctctcccgca agctcatcaa cggcatccgc gacaagcagt cggggaagac gatcctggac     2040

ttcctcaaga gcgacggctt cgccaaccga aacttcatgc agctaatcca cgacgacagc     2100

ctgacgttca aggaggacat ccagaaggcc caagtgagcg gccagggaga ctcgctacac     2160

gagcatatcg ccaacctggc tggcagcccg gcgattaaga aaggaatcct ccaaaccgtc     2220

aaagtggtgg acgagctggt gaaggtgatg ggccgccaca agcccgagaa cattgtgatc     2280

gagatggcgc gggagaacca gacgacgcag aagggccaaa aaaatagcag ggaaaggatg     2340

aagcgaatag aggaggggat caaggagctg gggagccaga ttctcaaaga gcacccggtc     2400

gagaacacac agctccagaa cgagaagctg tacctctact acctccaaaa cggccgcgat     2460

atgtacgtgg accaggaact agacatcaac cggctgagcg actatgacgt ggaccacatc     2520

gtgccgcagt ccttcctcaa ggacgactcg attgacaaca aagtgctcac tagatccgac     2580

aagaacagag gcaagagcga taacgtcccg tcggaggagg tcgtcaagaa aatgaaaaac     2640

tactggcggc agctcctaaa cgccaagctc atcacgcagc gtaagttcga caacctgacg     2700

aaggcggagc ggggcgggct gagcgagctg gacaaagcgg ggttcatcaa gcggcagctc     2760

gttgagacgc ggcagatcac aaagcacgtc gcgcaaatcc tcgactcccg catgaacacc     2820

aagtacgacg agaacgacaa gctcatccgg gaggtgaagg tcattaccct taaatcgaag     2880

ctcgtcagcg actttcgtaa ggacttccag ttctacaagg tcagagagat caacaactac     2940

caccacgccc acgacgccta tctgaacgcc gtggtgggca ccgcgcttat taagaagtac     3000

cccaagctgg agtccgagtt cgtgtacggc gactacaagg tttatgacgt caggaagatg     3060

atcgccaagt cggaacagga gatcggaaaa gctaccgcca aatatttctt ctatagcaac     3120

atcatgaact tcttcaaaac cgagatcacc ctcgccaacg gcgagatccg gaagcgcccg     3180

ctcatcgaga ccaacgggga gaccggggag atcgtctggg acaaggggcg ggacttcgct     3240

actgtccgaa aggtgctctc catgccacaa gtgaatatcg tcaagaaaac agaggtgcag     3300

accggagggt tcagtaagga gtccatcctg cccaagcgga actccgacaa gctaattgct     3360

cgcaaaaagg attgggatcc taaaaaatat ggcggcttcg actcgcccac ggtcgcctac     3420

tctgtgctgg tcgtggcgaa ggtggagaag ggcaagtcca agaagctcaa gagcgtcaag     3480

gagctgctgg ggatcacgat catggagcgt agttcgtttg agaagaatcc catcgacttc     3540

ctggaggcta agggctacaa ggaggtcaaa aaggacctca tcattaagct gccgaagtac     3600

agcctcttcg agctggagaa cgggcggaag cgtatgctcg cctccgctgg ggagttacaa     3660

aaggggaacg agctggcgct gccgtctaag tacgtcaact tcctgtacct ggcctcccac     3720

tacgagaagc tcaaggggtc gccggaggac aacgagcaga agcagctctt cgtagagcag     3780

cacaagcact acctggacga gatcatcgag cagatttcag agttctcaaa gcgggtcatc     3840

ctcgccgacg ccaacctgga caaggtgctc tcggcctaca acaagcaccg ggacaagccg     3900

atccgcgaac aggccgaaaa catcatccac ctgttcacgc tcaccaacct cggtgccccg     3960

gcggccttca agtactttga cacgaccatc gaccggaagc gctatacctc gacgaaggag     4020

gtgctggacg ccaccctgat ccaccagtcc atcaccgggc tttacgagac ccggatcgac     4080

ctctcgcagc ta                                                         4092


<210>  8
<211>  4101
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  8
gacaagaagt atagtattgg actcgccatc ggaaccaact ctgtggggtg ggctgttatt       60

acagatgaat ataaggtgcc atccaaaaag tttaaagttc tgggcaatac tgatagacac      120

tcaatcaaga agaatctgat aggtgcactt ctgtttgata gtggagagac tgccgaggca      180

accagactta aaaggactgc aagaagaaga tataccagaa gaaagaatag gatttgctat      240

ttgcaggaaa tcttcagcaa cgaaatggcc aaggttgatg actcattttt ccataggttg      300

gaggagagtt ttcttgtgga ggaagataag aagcacgaaa gacacccaat tttcgggaat      360

atagtggacg aggtggctta tcatgagaag tatcccacta tctaccacct gagaaagaaa      420

cttgtggact caaccgataa ggctgatctt aggcttatat acttggccct tgcacatatg      480

atcaaattca ggggccattt tcttatcgaa ggcgatctta atcccgataa ctcagatgtg      540

gacaagctgt ttatacaact tgtgcaaacc tacaatcaac tcttcgagga gaatcccatt      600

aacgcctccg gcgtggatgc aaaagccata ctgtcagcca gactgagcaa aagtaggaga      660

ctggagaatc ttatagccca actgcccggt gaaaagaaga atgggctctt cggaaatctg      720

atcgctcttt cattggggtt gacacccaac tttaagagta actttgactt ggcagaagat      780

gcaaagttgc agctcagtaa agacacatat gacgatgacc ttgacaatct cttggcacaa      840

ataggggatc aatacgctga ccttttcctc gctgccaaga acctcagcga cgctatactg      900

ttgtccgaca ttcttagggt taataccgaa attacaaagg cccctcttag tgcaagtatg      960

atcaaaaggt atgatgagca tcaccaagac cttacactgc tgaaggctct ggttagacag     1020

caactccctg aaaagtataa ggaaatattc ttcgaccaaa gtaagaacgg gtacgccggt     1080

tatattgatg ggggcgcaag tcaagaagaa ttttacaaat tcatcaagcc aattcttgaa     1140

aagatggacg ggactgagga attgctggtg aaactgaata gagaggacct tcttagaaaa     1200

cagaggacat ttgacaatgg gtccatccca caccagattc atctggggga actccacgca     1260

atattgagga gacaagaaga cttttaccca ttccttaagg ataatagaga gaaaatcgaa     1320

aaaatcctga ctttcaggat tccttactat gttgggccac tggccagggg gaactcaaga     1380

ttcgcttgga tgacaaggaa gtcagaagaa accataaccc cttggaattt tgaagaggtg     1440

gttgataagg gggcatcagc ccagtctttc atagagagga tgaccaactt tgataaaaat     1500

cttccaaatg agaaggtttt gccaaaacat agtcttttgt acgagtactt tactgtttat     1560

aacgaattga ccaaggtgaa gtatgtgacc gagggaatga ggaagccagc atttttgtcc     1620

ggggagcaaa agaaagcaat cgttgatctt ctcttcaaga ccaacagaaa agtgaccgtg     1680

aaacaactga aggaagacta cttcaaaaag atagaatgtt tcgattcagt ggaaattagc     1740

ggtgttgaag acaggttcaa tgcttcattg ggtacttacc acgacctgtt gaagataatc     1800

aaagacaagg actttctcga taatgaggag aacgaagaca tcttggaaga cattgtgctt     1860

acactcactt tgtttgagga cagggaaatg attgaggaaa gactcaaaac ttacgctcat     1920

ttgtttgatg ataaggttat gaaacaacta aaaagaagaa ggtacaccgg ctggggaaga     1980

ttgagtagga aactgatcaa cggtattaga gataaacaat ccggaaagac tatcctcgat     2040

ttccttaaga gtgatggctt tgcaaatagg aattttatgc agctgattca tgacgactca     2100

cttaccttca aagaagacat ccaaaaagct caggtgtctg ggcaaggcga cagtctgcat     2160

gaacatatag ctaacttggc tgggagtccc gccatcaaga aggggatact tcaaacagtt     2220

aaagttgtgg acgaattggt gaaggtaatg ggaaggcaca agcctgaaaa tatagtgata     2280

gaaatggcaa gggaaaatca aacaacccag aagggacaga agaacagtag ggaaaggatg     2340

aaaaggatag aagaggggat caaagagctt ggtagccaga tcctcaagga acatccagtg     2400

gagaataccc aacttcaaaa cgagaaactc tatttgtact acttgcagaa cggaagagat     2460

atgtatgtgg accaagagct tgatattaac aggctgagcg attatgacgt tgaccacata     2520

gtgccccaat cattcctcaa ggatgactct attgataata aggtgctgac aaggagtgac     2580

aagaatagag ggaaatccga caacgttcca tccgaggaag ttgtgaagaa gatgaagaac     2640

tactggaggc agttgctgaa cgctaagctc attacccaga ggaaattcga taacctgacc     2700

aaagcagaga gaggcgggct gagcgaactc gataaagcag gtttcatcaa gagacaactc     2760

gtggagacta ggcaaattac taagcacgtg gctcaaatac tcgacagcag gatgaacaca     2820

aagtacgacg agaacgacaa gctcattaga gaggttaagg ttattactct gaaaagtaaa     2880

ttggttagcg atttcagaaa ggatttccaa ttctataagg ttagagagat caacaattat     2940

catcatgcac atgatgccta tctgaatgct gtggttggta cagcccttat caagaagtac     3000

cctaagctag agagcgagtt tgtgtacgga gattataagg tgtatgatgt gaggaaaatg     3060

atcgctaaaa gtgagcaaga gattggaaag gctaccgcca aatacttctt ttattccaat     3120

attatgaatt tcttcaagac agaaatcacc ctggctaacg gcgagataag gaagaggccg     3180

cttatcgaaa ctaatgggga gacaggcgaa atagtgtggg acaaagggag ggatttcgca     3240

actgtgagga aggttttgag catgcctcag gtgaatatcg ttaagaaaac cgaagttcaa     3300

actggagggt tctctaagga aagcattctc cccaagagga actccgacaa gctgattgct     3360

agaaagaaag actgggaccc caagaagtat ggcggattcg actcacccac tgtggcatat     3420

agcgttctcg tggtggcaaa ggttgaaaag ggtaaatcca aaaaactcaa atccgtgaag     3480

gaactccttg gcataactat tatggaaagg agtagctttg aaaagaatcc catcgacttt     3540

ctcgaagcta agggctataa ggaagttaag aaggacctta taatcaaact tccaaaatac     3600

tccctttttg agttggaaaa cggcagaaag agaatgttgg ccagtgccgg ggagcttcaa     3660

aagggcaacg aactggctct gcctagcaaa tatgtgaact ttttgtatct ggcatcacac     3720

tacgagaaac ttaaaggctc tcctgaggac aacgagcaaa aacagctctt tgttgaacag     3780

cataagcact acctcgacga gattattgag cagatcagcg agttctcaaa gagagttatt     3840

ctggctgacg ctaatcttga caaggttttg tccgcttaca acaaacacag ggataagcca     3900

atcagggagc aggcagaaaa cataatccat ctctttaccc tgacaaacct cggtgccccc     3960

gctgctttca agtattttga tactaccatt gacaggaaga gatatacttc cactaaggaa     4020

gtgctcgacg caaccctcat acaccaaagt atcacaggcc tctatgaaac taggatagat     4080

ttgtctcaac ttgggggcga t                                               4101


<210>  9
<211>  4101
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  9
gacaaaaagt attccatcgg gcttgctatc ggaaccaact ctgtggggtg ggcagttatt       60

accgacgaat acaaggtgcc cagcaagaag tttaaggttc tggggaacac agatagacat      120

agcataaaga aaaacctgat aggcgcactg ttgttcgact ccggggaaac agccgaagct      180

accaggctga agagaactgc aagaagaagg tacaccagaa gaaaaaacag aatatgttat      240

ctccaagaga ttttctctaa cgagatggcc aaggtggacg actcattctt tcacagactg      300

gaagaatctt tccttgtgga agaagataag aaacacgaga ggcaccctat ttttggcaat      360

atcgtggatg aggtggctta ccacgaaaaa taccctacaa tataccacct caggaaaaaa      420

ttggttgata gtacagacaa ggccgacctc aggctcatct atttggccct ggcccatatg      480

attaaattca gggggcactt tctcatcgag ggagatttga accccgacaa cagtgatgtt      540

gataagctct ttattcagct cgtgcagact tacaatcagt tgtttgagga aaaccccatt      600

aatgcttccg gggtggacgc caaggcaatc ctttctgcaa gactctcaaa gtcaaggaga      660

ctcgaaaatc tgatagcaca gcttccagga gagaagaaga acgggctctt tggaaacctg      720

atcgctctgt cactcggact cacacccaat ttcaaaagca attttgattt ggcagaggac      780

gctaagctgc aactcagtaa ggatacctac gacgatgact tggataatct gctcgcacaa      840

attggggacc agtatgcaga cctgtttctc gcagctaaga acttgagtga cgccatattg      900

ctcagtgaca tcctcagggt taataccgag attacaaaag ctccactctc tgcaagcatg      960

atcaagaggt atgacgagca ccatcaagac ctgacactcc ttaaggcgtt ggttaggcag     1020

caacttcctg aaaagtataa ggaaatcttc ttcgatcaaa gcaaaaacgg ctacgccggc     1080

tatatagacg ggggagcatc ccaagaagaa ttttataagt tcataaaacc tatattggag     1140

aagatggacg ggacagagga attgctcgtg aaactgaaca gggaggatct cctcaggaag     1200

caaaggacct tcgacaatgg ctccatccca catcagattc acctcggcga actgcacgca     1260

atactgagaa gacaagagga cttttatcct ttcctgaagg acaacaggga gaaaatcgag     1320

aaaatcttga cattcagaat cccatactac gttgggcctc tggccagagg taacagtagg     1380

ttcgcctgga tgactaggaa atcagaggag actattacac cctggaactt tgaagaagtt     1440

gttgataagg gagcttcagc acaatcattc atcgaaagaa tgacaaactt tgacaaaaat     1500

ctgcctaatg agaaagtgct cccaaaacat tccctgctgt atgagtattt taccgtttat     1560

aacgagctta ccaaggtgaa atacgttact gaaggtatga gaaagccagc ttttctttca     1620

ggggagcaaa agaaggctat cgtggatctt ctctttaaga ccaacagaaa ggttaccgtg     1680

aagcagctta aggaagacta ctttaaaaag atcgagtgtt ttgactcagt ggaaataagc     1740

ggtgttgaag atagattcaa cgcatccttg ggaacttatc atgatcttct taagataatc     1800

aaggataaag actttctcga caacgaggaa aacgaagata tactggagga catagttctg     1860

acacttactt tgttcgagga tagggagatg atcgaggaaa gactgaaaac atatgctcac     1920

cttttcgacg acaaagttat gaaacaactc aagagaagga gatatacagg gtgggggaga     1980

ttgagcagga aactgattaa tggtatcaga gacaaacagt caggaaaaac aatactcgac     2040

tttttgaaat cagacgggtt cgcaaatagg aatttcatgc agcttataca cgacgattca     2100

cttactttta aagaggacat tcaaaaggct caagttagtg gacaaggtga ctccctccac     2160

gaacacatcg caaatctcgc tggcagccct gcaattaaga agggtatact ccagacagtt     2220

aaggttgttg acgagctggt taaagtgatg ggaagacaca aacccgagaa catagtgata     2280

gagatggcca gggaaaacca aaccactcaa aaagggcaga aaaattccag agagaggatg     2340

aaaaggattg aagaaggtat caaggagctg ggtagccaaa ttctgaaaga acatcctgtg     2400

gaaaacactc aactccagaa tgagaaactc tatctgtact atctgcaaaa tgggagagat     2460

atgtatgtgg accaggaact ggacataaac aggctctcag attacgatgt ggatcatatc     2520

gtgccacagt cctttcttaa ggatgatagc atcgacaata aggtgcttac caggtccgac     2580

aagaacaggg gaaagtcaga taacgtgcct tctgaagaag ttgttaaaaa gatgaagaac     2640

tactggagac agctgcttaa cgctaagctc ataacacaga ggaagtttga caacttgacc     2700

aaggccgaga gaggcggact ctcagaattg gataaggcag ggttcataaa aaggcagctg     2760

gtggaaacaa ggcagataac taaacatgtg gctcagatcc tcgatagtag gatgaataca     2820

aaatacgatg agaacgacaa gctcataagg gaggttaaag tgataactct gaaatccaaa     2880

ctggttagcg attttaggaa ggatttccag ttttacaaag ttagggagat caacaattat     2940

catcacgccc acgatgccta cttgaacgca gttgtgggta ctgcacttat caaaaagtac     3000

cctaagctgg aatccgagtt tgtttatgga gactataagg tgtacgacgt tagaaaaatg     3060

attgcaaagt cagagcagga gatagggaaa gccactgcaa aatatttctt ttatagcaat     3120

atcatgaatt tctttaagac agaaatcaca ctggccaatg gggaaataag gaagaggccc     3180

ctgatcgaaa ctaatggcga gacaggggag attgtgtggg ataaaggtag ggactttgca     3240

acagtgagga aagtgctgag catgccccaa gttaatatcg ttaaaaagac cgaggttcaa     3300

acagggggct ttagtaagga aagcattttg cccaagagga atagtgacaa attgattgct     3360

aggaaaaaag attgggaccc caaaaagtat ggcggatttg atagccccac tgttgcttac     3420

tccgtgctcg tggttgcaaa ggtggagaag ggaaagagca agaaactgaa gtcagttaag     3480

gaactccttg gtatcactat catggaaaga agctcctttg agaagaaccc tattgacttc     3540

ctggaggcta aagggtacaa agaggttaag aaagacctta tcattaaatt gcccaaatat     3600

agtcttttcg agcttgaaaa cggaagaaag aggatgcttg catccgctgg cgaattgcaa     3660

aagggcaatg agcttgctct cccttccaag tatgtgaact tcctttatct tgcctcacac     3720

tatgaaaaac tcaaaggttc acccgaagac aacgaacaaa agcaactatt tgtggaacaa     3780

cacaagcact acctggacga aatcattgag caaatttctg agttttcaaa aagggtaatc     3840

ttggctgacg caaatctcga caaagttttg tcagcttaca acaaacatag agataagcca     3900

attagagagc aagctgagaa tatcatccat ctgtttaccc tgactaacct tggagcgcct     3960

gctgctttta aatatttcga caccacaatc gacaggaaga ggtacactag cactaaggaa     4020

gttctcgacg ccaccctcat ccaccagagt attacaggcc tgtacgagac aagaattgat     4080

ctttctcaac ttggtggtga c                                               4101


<210>  10
<211>  4101
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  10
gataagaagt actcaatcgg tctggcaatc ggaaccaact ctgtgggttg ggcagtgatt       60

acagatgagt ataaggtgcc aagcaaaaaa ttcaaggtgc tgggtaatac cgacagacac      120

agcattaaga agaatttgat tggagcactc ctctttgact caggggaaac agcagaggca      180

acaaggctga agaggacagc aaggcggagg tacacaaggc ggaaaaacag gatatgctac      240

ctccaggaaa tctttagcaa cgagatggct aaagtggatg atagcttttt ccatagactc      300

gaagaatcct ttcttgttga agaggacaaa aagcatgaaa ggcatcccat cttcggcaat      360

atagttgatg aggttgcata ccatgagaag taccccacaa tctaccacct cagaaagaaa      420

cttgtggact ccacagataa agcagacctg aggctcatat acctcgcact cgcacacatg      480

atcaagttca gagggcactt tctcatcgaa ggtgacctga atccagataa ttcagatgtg      540

gataaactgt ttatacagct ggtgcaaaca tacaaccaac ttttcgagga aaacccaatc      600

aatgcctccg gtgttgatgc aaaggccatc ctgtcagcaa gactcagcaa aagcaggcgg      660

ctcgaaaacc tcatcgccca gcttcccggt gaaaagaaga acgggctctt tggtaatctc      720

atcgcattga gccttggtct tactccaaac ttcaagagca attttgatct ggcagaggat      780

gctaaactgc aactctcaaa ggacacatat gacgatgacc ttgacaatct gttggcccag      840

atcggggacc aatatgcaga cctcttcctg gccgcaaaga atctgtcaga tgcaatcctc      900

ttgtccgaca tactgagagt taacactgag atcacaaagg cacctctgtc cgcctccatg      960

attaagagat acgatgagca tcaccaggat ctgactttgc tcaaagccct cgttagacag     1020

cagttgccag aaaagtacaa agaaatattc tttgatcaat caaaaaacgg atatgcaggg     1080

tacatcgacg gtggggcaag ccaggaagag ttctacaaat tcatcaaacc tatcctggaa     1140

aagatggatg ggacagaaga gctgctggtt aagctgaata gggaagacct cctcagaaag     1200

cagaggacat ttgataacgg gagcatccct catcaaatcc acctcggtga actccatgct     1260

atcctgagaa ggcaggaaga cttttatcca tttttgaagg acaataggga gaaaatcgaa     1320

aaaatcctga cattcagaat cccatactac gttggtcctc tggcaagagg taacagtagg     1380

ttcgcatgga tgacaaggaa aagcgaggag acaatcacac cctggaattt tgaggaagtt     1440

gttgacaagg gtgccagcgc acaatccttt atcgaaagaa tgacaaattt cgacaagaat     1500

ctgcctaacg aaaaggttct cccaaagcat tcactcctgt acgaatattt tacagtttat     1560

aacgaactga ctaaagttaa atacgttacc gagggtatga ggaagccagc attcctttcc     1620

ggggaacaga agaaagctat tgtggacctc ctgttcaaga caaatagaaa agtgacagtt     1680

aagcaactca aagaggatta cttcaaaaag atcgaatgtt ttgactctgt ggagatcagc     1740

ggggtggagg atagattcaa cgccagcctg ggtacatatc atgatctcct gaaaatcatt     1800

aaagacaagg acttccttga caacgaggag aacgaggaca ttctggaaga cattgttctg     1860

accctcacac tctttgagga tagggagatg attgaggaaa gactgaagac ctacgcccac     1920

ctctttgacg ataaagtgat gaaacagctc aagagaagaa ggtatacagg ttgggggaga     1980

ctgagcagga agttgatcaa tgggattagg gacaaacagt ccgggaaaac aatcctcgat     2040

tttctgaagt cagacggttt cgcaaacaga aattttatgc agctcattca cgatgacagc     2100

ttgacattca aggaagacat ccaaaaggct caagtgagcg gccaagggga tagcctccac     2160

gagcatattg caaatctggc aggttcacca gccatcaaaa agggcatact tcagacagtt     2220

aaggttgtgg acgaattggt taaagttatg ggcaggcata agccagagaa tatcgttatc     2280

gaaatggcaa gggagaacca aacaactcaa aaagggcaga aaaatagcag agagaggatg     2340

aaaagaatcg aggaagggat caaggaactt gggtcccaaa tcctcaagga gcacccagtt     2400

gaaaatactc aactgcaaaa cgagaagctc tatctctact atctccaaaa cgggagggat     2460

atgtatgttg accaggagct ggatattaac agactgtcag attatgatgt tgatcatatc     2520

gtgccccagt cattcctgaa ggacgattcc atcgacaaca aagttctcac aaggtccgat     2580

aaaaacaggg gcaagtccga taacgttcca agcgaagaag tggtgaaaaa gatgaaaaac     2640

tattggagac aacttctgaa tgcaaagttg attactcaga gaaagtttga caacctcaca     2700

aaagcagaaa gaggcgggct tagcgaactc gataaggcag ggtttatcaa aagacagctg     2760

gttgagacaa ggcagatcac aaaacatgtg gcacagatcc ttgactcaag gatgaatacc     2820

aagtatgatg agaatgataa gttgatcagg gaggttaaag ttatcacact caaatccaaa     2880

ctggtgtcag acttcaggaa agactttcaa ttttataagg tgagggagat caataactac     2940

caccatgcac atgacgccta cctgaacgca gtggtgggta cagcattgat taaaaaatac     3000

cctaagctgg agtctgagtt tgtgtacggg gactacaagg tgtacgacgt gaggaaaatg     3060

atagccaagt ccgagcagga gatcgggaaa gcaacagcta agtatttctt ttacagtaat     3120

atcatgaatt tctttaaaac tgagattact ctggcaaacg gggagatcag gaaaagaccc     3180

ctcatcgaga ctaatggtga aacaggtgag atcgtttggg acaaggggag ggattttgct     3240

actgttagaa aagttctgag tatgccacaa gtgaatattg tgaaaaagac agaagttcag     3300

acaggtgggt tctccaaaga atccatcctg cccaagagaa attcagacaa gctcatcgca     3360

agaaagaagg actgggaccc taagaagtac ggaggatttg acagccccac cgtggcctat     3420

tccgtgcttg ttgtggcaaa ggtggagaaa gggaagagca aaaaactgaa atccgtgaaa     3480

gaactgctgg gaattaccat catggaaaga agctcctttg agaagaaccc aatcgacttc     3540

ctggaagcaa aaggatataa ggaagtgaaa aaggacctca ttatcaagct cccaaaatac     3600

tcacttttcg agttggagaa cggtagaaag aggatgctgg caagcgcagg ggaacttcag     3660

aaaggcaatg agctggcatt gccatcaaag tatgtgaact tcctctactt ggccagccat     3720

tacgagaaac ttaaaggtag cccagaagat aacgagcaaa aacagctctt tgtggaacag     3780

cataagcatt atctggatga gatcatagaa caaatctcag agttttccaa gagagttatc     3840

ctcgcagatg caaacctgga taaggttctc tcagcctata ataagcatag agacaagcca     3900

attagagagc aagcagagaa cattatccac ttgttcactc ttacaaacct gggggcacca     3960

gccgccttca aatatttcga tacaacaata gacagaaaga ggtataccag caccaaagaa     4020

gttctcgacg ccacactgat ccatcaatca atcacaggcc tttacgaaac taggatcgac     4080

ttgtcacaac tgggtgggga t                                               4101


<210>  11
<211>  3307
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  11
gagcaaggac acctacgacg acgacttgga caacctattg gcccagatag gtgaccagta       60

tgcagacctc ttccttgcgg ccaagaactt gagtgacgct atactgctca gtgacatcct      120

gagggtgaac actgagatca ctaaggcccc tctctctgcc tcaatgatta agcgttacga      180

cgagcatcac caggatctca ccctgcttaa ggcccttgtt cggcagcagc tccctgagaa      240

gtacaaggag atattttttg accagtctaa gaacggctac gccggttaca ttgacggtgg      300

ggcaagccag gaggagttct acaagttcat caagccgatc cttgagaaga tggacggcac      360

cgaggagcta cttgtcaagt tgaaccggga agacctgctc cggaaacagc gtacattcga      420

caacggcagc atccctcacc agatccacct gggcgaacta cacgccatcc tccgacgtca      480

ggaggacttc tatccattct tgaaagataa cagggaaaaa atcgaaaaaa tacttacgtt      540

tcgaatacct tactacgtgg ggccccttgc tcggggaaac tccagattcg catggatgac      600

caggaagtca gaggagacca tcacaccctg gaactttgag gaggtggttg acaaaggtgc      660

ttctgcccag tccttcattg agcggatgac taacttcgac aagaacctgc ccaacgagaa      720

ggtgctgcca aagcacagcc tgctctacga atactttact gtgtacaatg agctgacgaa      780

ggtgaagtac gtgacagagg ggatgcggaa gcccgctttc ctgagcggcg agcaaaaaaa      840

agcaatcgtg gacctactgt tcaagaccaa ccgaaaggtg acagtgaagc agctcaagga      900

ggactacttc aaaaaaatcg agtgcttcga ctctgttgag ataagcggcg tggaggaccg      960

attcaacgcc tcattgggaa cctatcacga cctgctcaag atcattaagg acaaggactt     1020

cctggataat gaggagaatg aggacatcct ggaggatatt gtgctgaccc ttactctatt     1080

cgaggacagg gagatgatcg aggagcgact caagacctac gctcacctgt tcgacgacaa     1140

ggttatgaag caattgaagc gtaggcgata cacggggtgg ggaagactct cccgaaaact     1200

gataaacggc atcagggaca agcagtcagg gaagacgatc ttggacttcc tgaaatccga     1260

cgggttcgcc aaccgcaact tcatgcagct cattcacgac gactcactaa cgttcaaaga     1320

ggacattcag aaggctcaag tcagtggaca aggcgactcc ctgcacgagc acattgcaaa     1380

ccttgcgggc tccccggcga ttaaaaaggg cattctccaa acggttaagg tggtggacga     1440

gctggtgaag gtgatgggcc gacacaagcc tgagaacatc gtgatcgaga tggccaggga     1500

gaaccagact acccagaagg gtcagaagaa ctctcgggaa cgtatgaagc gtattgagga     1560

ggggattaag gagttgggct ctcaaatcct caaggagcac cctgtggaga acactcagct     1620

ccaaaacgag aagctgtacc tgtactacct gcaaaacggg cgcgatatgt acgtggatca     1680

ggagttggac atcaacaggc ttagcgatta cgacgtggac cacatcgtgc cacagtcatt     1740

cttaaaggac gacagcatcg acaacaaggt tctgacgagg agcgacaaga atcgagggaa     1800

aagtgacaat gttccatccg aggaggtggt caagaaaatg aagaactatt ggcgtcagct     1860

tctgaacgcc aagctcatca cccagcggaa attcgacaac ctgactaagg ctgagcgagg     1920

cggactctcc gagcttgaca aggctggctt catcaagcgg cagttggtcg aaacccgaca     1980

gataacgaag cacgttgccc agatacttga ctcccgtatg aacaccaagt acgacgagaa     2040

cgacaagctc atcagggagg tgaaggtcat tacccttaag tccaaactcg tcagcgactt     2100

tcgtaaggac ttccagttct acaaggtgcg cgagatcaat aactaccacc acgcacacga     2160

cgcctacctg aacgcagtgg ttggaaccgc gttgattaaa aagtacccca agttggagtc     2220

ggagttcgtt tacggggact acaaggtgta cgacgttcgg aagatgatcg ccaagtctga     2280

acaggagatc gggaaagcaa ccgccaagta tttcttctat agcaacatca tgaacttctt     2340

taaaaccgag atcacacttg ccaatggcga gatccgtaag aggccgctga tcgagacaaa     2400

tggggagact ggcgagatcg tgtgggacaa gggccgcgac ttcgcaaccg ttcggaaagt     2460

cttgtccatg cctcaagtca acatcgtcaa gaagactgag gtgcaaacag gcgggttctc     2520

gaaggagtcc atactgccca agaggaactc agacaagctc atagcacgca aaaaagactg     2580

ggatccaaag aaatacggcg ggttcgactc gccgacagtc gcatactccg tgttagtggt     2640

ggctaaagtg gaaaagggga agtccaagaa gctcaagtcc gtcaaggagt tgctcgggat     2700

caccattatg gaacggtcct cattcgagaa gaatcccatt gacttcctag aggcgaaggg     2760

ctacaaagag gtcaaaaagg acctaattat taagctcccc aagtattcac tcttcgaact     2820

tgaaaatggt cgtaagcgga tgttggcaag cgctggagag cttcagaagg ggaacgagct     2880

tgcactgcct tccaagtacg tgaacttcct gtacctcgcc tctcattacg agaagttgaa     2940

gggctcaccg gaggacaacg agcagaagca gttgttcgtg gagcagcaca agcactacct     3000

cgacgagatc attgagcaga taagtgagtt cagcaaacgg gtgatccttg ccgacgctaa     3060

cctggacaag gtgctgagcg cctacaacaa gcacagagac aagccgatcc gagagcaagc     3120

ggagaacatc atacacctgt tcaccctcac gaacctcggg gctcccgcag ccttcaaata     3180

ttttgacacg accatcgacc gtaaacgcta cactagcacg aaggaggtgc tggacgctac     3240

ccttatccac cagtccatca ccggcctgta cgagacgaga atcgacttgt cgcagctcgg     3300

tggtgac                                                               3307


<210>  12
<211>  4101
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  12
gacaaaaaat actcaattgg tctggcaatt gggaccaaca gtgtcggatg ggccgtgatt       60

accgacgagt acaaggtgcc gtccaaaaaa ttcaaggtgc ttgggaacac cgaccgccac      120

tcgatcaaga aaaacctaat cggtgcgttg cttttcgaca gtggggagac cgccgaggca      180

acacgcttaa aacgcacagc taggaggaga tatacacggc gcaagaaccg aatatgctac      240

ttacaggaga tattctccaa tgagatggcg aaggtggacg actctttctt ccatcggctt      300

gaggaatcct tcctggtcga ggaggacaag aagcacgagc gacacccgat attcgggaac      360

atcgttgatg aggtggcgta ccacgagaag tacccaacga tataccactt acgcaagaag      420

ctcgtggact ctacggacaa ggccgacttg cgccttatct acttggcact ggcccacatg      480

attaagttcc gaggccactt ccttatcgag ggtgacctga accccgataa ctccgacgtg      540

gacaagctct tcatccaact cgtccagaca tacaaccagc tattcgagga gaatcctatc      600

aacgcctctg gggtggacgc taaagctatc ctctcagccc gcctgtcaaa gtcgaggagg      660

ttggagaacc taatcgccca gcttccaggc gagaagaaaa atgggctgtt cggaaacctt      720

atcgcactct cactgggcct aaccccgaac ttcaagtcca acttcgacct ggcagaggac      780

gcgaaattgc agttgtcgaa agacacctat gacgatgacc tggacaacct gttggcccag      840

ataggggacc agtacgccga cctgttccta gcggccaaga acctgtccga cgccatcttg      900

ctgtcggata tactgcgggt gaacaccgag atcactaaag cacctctctc cgccagcatg      960

attaagcgtt acgacgagca ccaccaagat ttgaccctgc taaaggcact tgtacggcag     1020

cagcttcccg agaagtacaa ggagatcttt ttcgaccaaa gcaagaacgg ctacgccggg     1080

tacatcgacg gaggtgccag ccaggaggag ttctacaagt tcattaagcc catcctggag     1140

aagatggacg ggactgagga actacttgtg aagctgaacc gggaagactt actacggaag     1200

cagcgtacct tcgacaacgg ttctatccca catcagatcc atcttgggga gttgcacgcg     1260

atcctgcgac gccaggagga cttttacccc ttcctgaaag acaaccgcga gaaaatcgag     1320

aagatactga ccttcagaat accttactac gtcggacccc ttgcgcgagg caactcaaga     1380

ttcgcgtgga tgaccaggaa atcagaggag accatcacac cctggaattt cgaggaggtg     1440

gttgacaagg gtgcctccgc ccagtccttt atcgaacgaa tgaccaactt cgacaagaac     1500

ttgcccaacg agaaggtgct ccccaaacac agcctcctct acgaatattt cacagtgtac     1560

aacgagctta ctaaagttaa gtatgttact gagggcatga ggaaacccgc cttcctgtca     1620

ggcgagcaga agaaagctat tgtggacctc cttttcaaga ccaaccggaa ggtgacagtg     1680

aagcagctca aggaggacta cttcaagaag atagagtgct tcgacagcgt ggagatcagc     1740

ggggtggagg acagattcaa tgcctctctc ggaacatacc acgacttgct taagatcatc     1800

aaggacaagg acttcctcga caacgaggaa aacgaggata ttctggagga tattgttctg     1860

actcttaccc tgttcgagga ccgggagatg atcgaggagc gtctcaagac ctacgcccac     1920

ctgttcgacg acaaagttat gaagcagctc aagcgtcgga gatataccgg atggggccgt     1980

ctgtctcgga agctcatcaa cgggatcagg gacaagcagt cagggaagac gatcttagac     2040

ttccttaagt ctgacggctt cgccaacagg aacttcatgc agttgatcca cgacgacagc     2100

cttaccttca aggaggacat ccagaaggcc caagtgagtg gccagggtga cagcctccac     2160

gagcatattg ctaatcttgc gggttcccca gcgattaaaa agggcatact tcaaaccgtt     2220

aaggtggtgg acgagcttgt caaggtgatg gggcgacaca agcccgagaa catcgtgatc     2280

gagatggcca gggagaacca gaccacccag aaggggcaga agaatagccg agaacgcatg     2340

aagcgcatcg aggaggggat taaggagcta gggagccaga tcctcaagga acatcccgtc     2400

gagaacaccc agctccagaa cgagaagcta tacctctact acttgcaaaa cgggagggat     2460

atgtacgtgg atcaggagtt ggacattaac cgcctaagcg actacgacgt agatcacatc     2520

gtgcctcagt cattcctcaa agacgacagc attgacaaca aagtcttgac ccgatccgac     2580

aagaaccgag gaaaatccga caatgtgccc tcagaggagg tcgtcaagaa aatgaagaac     2640

tattggaggc agctacttaa cgccaaactc ataacccagc ggaagttcga caacctgaca     2700

aaggctgagc ggggtgggct cagcgagctt gacaaggctg gcttcatcaa gcggcagttg     2760

gtggagacaa gacagataac gaagcacgtg gctcagatcc tggactctcg catgaacacg     2820

aagtacgacg agaacgacaa attgatccgc gaggtcaagg ttattacgct caagagcaaa     2880

cttgtcagcg atttccgcaa ggacttccag ttctacaagg tgagggagat taacaactac     2940

caccatgcac atgatgccta cttgaacgca gtggtgggga ccgcgcttat taaaaagtac     3000

cctaagttgg agtcagagtt cgtttatggg gactacaagg tgtacgacgt ccggaagatg     3060

attgcaaagt ctgaacagga aatcgggaag gccaccgcca aatatttctt ctacagtaac     3120

attatgaatt tttttaagac tgaaattact ctcgcaaacg gcgagatcag gaagcgtccc     3180

ctcatcgaga caaacgggga gaccggggag atagtctggg acaaggggcg ggacttcgct     3240

acggtgagga aggtgctctc gatgccacaa gtgaacatcg tcaaaaagac agaggtgcag     3300

accggtggct tctcaaagga gtcaatcctg ccaaaacgta acagcgacaa gctcatcgcc     3360

cgcaagaaag actgggaccc taagaagtat ggtgggttcg actcaccgac ggtcgcatac     3420

tccgttctgg tcgtggcaaa ggtggaaaag ggcaagtcca aaaaactgaa atccgtgaag     3480

gagttgcttg gcattaccat catggaacgc agcagcttcg agaagaaccc cattgacttc     3540

ctggaggcta aagggtacaa ggaggtcaag aaagatttaa ttattaagct acctaagtac     3600

agcttgttcg agctggagaa cggccgaaaa cgaatgctcg catccgccgg ggaacttcaa     3660

aagggcaacg agcttgcgct gccctccaag tacgtgaact tcctgtactt ggcatcccac     3720

tacgagaaac tcaagggtag cccagaggac aacgagcaga agcagctatt cgtggagcag     3780

cacaagcact acctcgacga gataatcgag cagatcagtg agttcagtaa gcgggtgata     3840

ctcgcggacg ccaacttgga caaggtgctt agtgcctaca acaagcaccg tgacaagccc     3900

atccgagaac aggctgagaa catcatccac cttttcactc tgacaaacct cggtgctccc     3960

gccgccttca aatacttcga cactaccatc gacaggaagc gctacacatc tacgaaggaa     4020

gttcttgacg ctacgcttat tcatcagtct atcacagggc tgtacgagac aaggatcgac     4080

cttagccaac tcggcgggga t                                               4101


<210>  13
<211>  4101
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9 nt sequence

<400>  13
gacaagaagt acagcatcgg gctggcgatc gggaccaact ccgtcggctg ggctgtgatt       60

accgacgagt acaaggtgcc atccaagaag ttcaaggtcc tcggcaacac tgaccggcac      120

agcattaaga agaacctgat tggggcgctg ctgttcgatt cgggggagac tgcggaggcg      180

accaggctga agcggactgc gcgccggagg tacaccagga ggaagaatcg gatctgctac      240

ctccaggaga ttttctcgaa tgagatggcc aaggtggacg attccttctt ccatcgcctg      300

gaggagtcgt tcctcgttga ggaggacaag aagcatgaga ggcatcccat tttcgggaat      360

atcgttgacg aggtggctta ccatgagaag tacccgacca tctaccatct gcggaagaag      420

ctcgtcgatt cgaccgataa ggccgacctg cggctgatct acctggccct cgcgcacatg      480

attaagttcc ggggccattt cctcatcgag ggcgacctca acccggacaa ctcggacgtg      540

gataagctct tcattcagct cgtgcagaca tacaaccagc tcttcgagga gaatcccatt      600

aacgcctcgg gggtcgacgc taaggctatt ctctcggctc ggctgtcgaa gtcgcgccgg      660

ctggagaatc tcattgccca gctcccaggc gagaagaaga acggcctctt cggcaacctg      720

attgccctgt cgctggggct cacaccgaat ttcaagtcga acttcgacct cgccgaggac      780

gctaagctcc agctcagcaa ggatacttac gatgatgacc tcgataacct gctcgcccag      840

attggggatc agtacgcgga tctgttcctc gcggccaaga atctcagcga tgctattctc      900

ctgtcggaca ttctccgcgt caacacagag attactaagg ccccactgtc ggcgagcatg      960

attaagaggt acgatgagca tcatcaggac ctgacactgc tcaaggcgct ggtccggcag     1020

cagctccccg agaagtacaa ggagattttc ttcgatcagt caaagaatgg gtacgcgggc     1080

tacattgatg gcggcgcgtc ccaggaggag ttctacaagt tcattaagcc catcctggag     1140

aagatggacg ggaccgagga gctgctggtg aagctcaatc gggaggacct gctccggaag     1200

cagcgcacat tcgacaatgg ctcgattcct caccagattc acctgggcga gctgcacgcc     1260

attctccgca ggcaggagga cttctacccg ttcctcaagg acaaccgcga gaagatcgag     1320

aagatcctga ccttccggat tccatactac gtggggccgc tcgcgcgggg gaactcccgg     1380

ttcgcgtgga tgactcgcaa gtccgaagaa acgattacac cgtggaattt cgaggaggtc     1440

gtcgacaagg gcgctagtgc gcagtcattc attgagagga tgaccaattt cgataagaac     1500

ctgcctaacg agaaggtgct gccgaagcat tcgctgctct acgagtactt caccgtttac     1560

aatgagctga ccaaggtgaa gtatgtgact gagggcatga ggaagccagc gttcctgagc     1620

ggcgagcaga agaaggctat cgtggacctg ctcttcaaga ctaaccggaa ggtgactgtg     1680

aagcagctca aggaggacta cttcaagaag attgagtgct tcgattccgt tgagattagc     1740

ggggtggagg atcggttcaa tgcttcgctc gggacatacc acgatctcct gaagatcatt     1800

aaggataagg acttcctcga caacgaggag aacgaggaca ttctcgaaga tattgtcctg     1860

accctcaccc tcttcgagga tcgggagatg atcgaggaga ggctcaagac atacgctcat     1920

ctgttcgatg ataaggtcat gaagcagctg aagcgcaggc ggtacacagg gtgggggcgg     1980

ctgagccgga agctgatcaa cgggattcgg gataagcagt ccgggaagac aattctcgac     2040

ttcctcaagt ccgacgggtt cgctaaccgg aacttcatgc agctcattca tgatgactcg     2100

ctgacattca aggaggatat tcagaaggcg caggtttcgg ggcagggcga ctcgctccac     2160

gagcatattg cgaatctggc gggctccccc gcgattaaga agggcattct gcaaaccgtc     2220

aaggtggttg atgagctggt caaggtcatg gggcggcata agccagagaa tattgtcatc     2280

gagatggcgc gggagaatca gaccacacag aaggggcaga agaactcacg ggagcggatg     2340

aagcgcatcg aggagggcat caaggagctg gggtcgcaga tcctgaagga gcatcccgtg     2400

gagaacactc agctgcaaaa tgagaagctg tacctctact acctccagaa cgggagggac     2460

atgtatgtgg atcaggagct ggatattaat aggctgagcg attacgatgt cgaccacatt     2520

gtcccacagt cgttcctgaa ggacgacagc attgacaaca aggtgctgac ccgctcggat     2580

aagaacaggg gcaagagcga taatgttcca agcgaggagg ttgtgaagaa gatgaagaac     2640

tactggcggc agctcctgaa cgcgaagctc atcacacagc ggaagttcga caacctcacc     2700

aaggctgagc gcgggggcct gagcgagctg gacaaggcgg ggttcattaa gaggcagctg     2760

gtcgagacac ggcagattac aaagcatgtt gcgcagattc tcgattcccg gatgaacacc     2820

aagtacgatg agaacgataa gctgattcgg gaggtcaagg taattaccct gaagtccaag     2880

ctggtgtccg acttcaggaa ggacttccag ttctacaagg ttcgggagat caacaactac     2940

caccacgcgc atgatgccta cctcaacgcg gtcgtgggga ccgctctcat caagaagtac     3000

ccaaagctgg agtcagagtt cgtctacggg gattacaagg tttacgacgt gcggaagatg     3060

atcgctaaga gcgagcagga gattggcaag gctaccgcta agtacttctt ctactccaac     3120

atcatgaact tcttcaagac agagattacc ctcgcgaatg gcgagatccg gaagaggccc     3180

ctcatcgaga caaatgggga gacaggggag attgtctggg ataaggggcg ggatttcgcg     3240

accgtccgga aggtcctgtc gatgccccag gttaatattg tcaagaagac tgaggtccag     3300

actggcggct tctcaaagga gtcgattctc ccaaagagga actccgataa gctcattgct     3360

cggaagaagg attgggaccc caagaagtac gggggattcg actcccccac tgttgcttac     3420

tctgttctgg ttgttgctaa ggtggagaag gggaagtcga agaagctgaa gagcgtgaag     3480

gagctgctcg ggattacaat tatggagagg tcatccttcg agaagaatcc catcgacttc     3540

ctggaggcca agggctacaa ggaggtgaag aaggacctga ttattaagct gcccaagtac     3600

tcgctcttcg agctggagaa tgggcggaag cggatgctgg cgtccgcggg ggagctgcaa     3660

aaggggaacg agctggcgct cccctccaag tatgtgaact tcctctacct ggcgtcgcac     3720

tacgagaagc tgaaggggtc cccagaggat aatgagcaga agcagctctt cgtcgagcag     3780

cataagcact acctggacga gattatcgag cagattagcg agttctcgaa gcgggtcatc     3840

ctcgcggatg cgaacctgga taaggtgctc agcgcctaca ataagcaccg ggacaagccg     3900

attcgggagc aggcggagaa tattattcac ctcttcacac tcaccaacct cggggcacca     3960

gctgcgttca agtacttcga cactactatc gaccggaagc ggtacacctc gacgaaggag     4020

gtgctcgacg ccaccctcat tcaccagtcg atcacaggcc tgtacgagac acggattgac     4080

ctgtcccagc tcgggggcga c                                               4101


<210>  14
<211>  1367
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nCas9

<400>  14

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  15
<211>  1367
<212>  PRT
<213>  Artificial sequence

<220>
<223>  enCas9

<400>  15

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Ala Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Ala Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Ala Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  16
<211>  1228
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  16

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Ala 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  17
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp.

<400>  17

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  18
<211>  1241
<212>  PRT
<213>  Butyrivibrio proteoclasticus

<400>  18

Met Leu Leu Tyr Glu Asn Tyr Thr Lys Arg Asn Gln Ile Thr Lys Ser 
1               5                   10                  15      


Leu Arg Leu Glu Leu Arg Pro Gln Gly Lys Thr Leu Arg Asn Ile Lys 
            20                  25                  30          


Glu Leu Asn Leu Leu Glu Gln Asp Lys Ala Ile Tyr Ala Leu Leu Glu 
        35                  40                  45              


Arg Leu Lys Pro Val Ile Asp Glu Gly Ile Lys Asp Ile Ala Arg Asp 
    50                  55                  60                  


Thr Leu Lys Asn Cys Glu Leu Ser Phe Glu Lys Leu Tyr Glu His Phe 
65                  70                  75                  80  


Leu Ser Gly Asp Lys Lys Ala Tyr Ala Lys Glu Ser Glu Arg Leu Lys 
                85                  90                  95      


Lys Glu Ile Val Lys Thr Leu Ile Lys Asn Leu Pro Glu Gly Ile Gly 
            100                 105                 110         


Lys Ile Ser Glu Ile Asn Ser Ala Lys Tyr Leu Asn Gly Val Leu Tyr 
        115                 120                 125             


Asp Phe Ile Asp Lys Thr His Lys Asp Ser Glu Glu Lys Gln Asn Ile 
    130                 135                 140                 


Leu Ser Asp Ile Leu Glu Thr Lys Gly Tyr Leu Ala Leu Phe Ser Lys 
145                 150                 155                 160 


Phe Leu Thr Ser Arg Ile Thr Thr Leu Glu Gln Ser Met Pro Lys Arg 
                165                 170                 175     


Val Ile Glu Asn Phe Glu Ile Tyr Ala Ala Asn Ile Pro Lys Met Gln 
            180                 185                 190         


Asp Ala Leu Glu Arg Gly Ala Val Ser Phe Ala Ile Glu Tyr Glu Ser 
        195                 200                 205             


Ile Cys Ser Val Asp Tyr Tyr Asn Gln Ile Leu Ser Gln Glu Asp Ile 
    210                 215                 220                 


Asp Ser Tyr Asn Arg Leu Ile Ser Gly Ile Met Asp Glu Asp Gly Ala 
225                 230                 235                 240 


Lys Glu Lys Gly Ile Asn Gln Thr Ile Ser Glu Lys Asn Ile Lys Ile 
                245                 250                 255     


Lys Ser Glu His Leu Glu Glu Lys Pro Phe Arg Ile Leu Lys Gln Leu 
            260                 265                 270         


His Lys Gln Ile Leu Glu Glu Arg Glu Lys Ala Phe Thr Ile Asp His 
        275                 280                 285             


Ile Asp Ser Asp Glu Glu Val Val Gln Val Thr Lys Glu Ala Phe Glu 
    290                 295                 300                 


Gln Thr Lys Glu Gln Trp Glu Asn Ile Lys Lys Ile Asn Gly Phe Tyr 
305                 310                 315                 320 


Ala Lys Asp Pro Gly Asp Ile Thr Leu Phe Ile Val Val Gly Pro Asn 
                325                 330                 335     


Gln Thr His Val Leu Ser Gln Leu Ile Tyr Gly Glu His Asp Arg Ile 
            340                 345                 350         


Arg Leu Leu Leu Glu Glu Tyr Glu Lys Asn Thr Leu Glu Val Leu Pro 
        355                 360                 365             


Arg Arg Thr Lys Ser Glu Asp Ala Arg Tyr Asp Lys Phe Val Asn Ala 
    370                 375                 380                 


Val Pro Lys Lys Val Ala Lys Glu Ser His Thr Phe Asp Gly Leu Gln 
385                 390                 395                 400 


Lys Met Thr Gly Asp Asp Arg Leu Phe Ile Leu Tyr Arg Asp Glu Leu 
                405                 410                 415     


Ala Arg Asn Tyr Met Arg Ile Lys Glu Ala Tyr Gly Thr Phe Glu Arg 
            420                 425                 430         


Asp Ile Leu Lys Ser Arg Arg Gly Ile Lys Gly Asn Arg Asp Val Gln 
        435                 440                 445             


Glu Ser Leu Val Ser Phe Tyr Asp Glu Leu Thr Lys Phe Arg Ser Ala 
    450                 455                 460                 


Leu Arg Ile Ile Asn Ser Gly Asn Asp Glu Lys Ala Asp Pro Ile Phe 
465                 470                 475                 480 


Tyr Asn Thr Phe Asp Gly Ile Phe Glu Lys Ala Asn Arg Thr Tyr Lys 
                485                 490                 495     


Ala Glu Asn Leu Cys Arg Asn Tyr Val Thr Lys Ser Pro Ala Asp Asp 
            500                 505                 510         


Ala Arg Ile Met Ala Ser Cys Leu Gly Thr Pro Ala Arg Leu Arg Thr 
        515                 520                 525             


His Trp Trp Asn Gly Glu Glu Asn Phe Ala Ile Asn Asp Val Ala Met 
    530                 535                 540                 


Ile Arg Arg Gly Asp Glu Tyr Tyr Tyr Phe Val Leu Thr Pro Asp Val 
545                 550                 555                 560 


Lys Pro Val Asp Leu Lys Thr Lys Asp Glu Thr Asp Ala Gln Ile Phe 
                565                 570                 575     


Val Gln Arg Lys Gly Ala Lys Ser Phe Leu Gly Leu Pro Lys Ala Leu 
            580                 585                 590         


Phe Lys Cys Ile Leu Glu Pro Tyr Phe Glu Ser Pro Glu His Lys Asn 
        595                 600                 605             


Asp Lys Asn Cys Val Ile Glu Glu Tyr Val Ser Lys Pro Leu Thr Ile 
    610                 615                 620                 


Asp Arg Arg Ala Tyr Asp Ile Phe Lys Asn Gly Thr Phe Lys Lys Thr 
625                 630                 635                 640 


Asn Ile Gly Ile Asp Gly Leu Thr Glu Glu Lys Phe Lys Asp Asp Cys 
                645                 650                 655     


Arg Tyr Leu Ile Asp Val Tyr Lys Glu Phe Ile Ala Val Tyr Thr Arg 
            660                 665                 670         


Tyr Ser Cys Phe Asn Met Ser Gly Leu Lys Arg Ala Asp Glu Tyr Asn 
        675                 680                 685             


Asp Ile Gly Glu Phe Phe Ser Asp Val Asp Thr Arg Leu Cys Thr Met 
    690                 695                 700                 


Glu Trp Ile Pro Val Ser Phe Glu Arg Ile Asn Asp Met Val Asp Lys 
705                 710                 715                 720 


Lys Glu Gly Leu Leu Phe Leu Val Arg Ser Met Phe Leu Tyr Asn Arg 
                725                 730                 735     


Pro Arg Lys Pro Tyr Glu Arg Thr Phe Ile Gln Leu Phe Ser Asp Ser 
            740                 745                 750         


Asn Met Glu His Thr Ser Met Leu Leu Asn Ser Arg Ala Met Ile Gln 
        755                 760                 765             


Tyr Arg Ala Ala Ser Leu Pro Arg Arg Val Thr His Lys Lys Gly Ser 
    770                 775                 780                 


Ile Leu Val Ala Leu Arg Asp Ser Asn Gly Glu His Ile Pro Met His 
785                 790                 795                 800 


Ile Arg Glu Ala Ile Tyr Lys Met Lys Asn Asn Phe Asp Ile Ser Ser 
                805                 810                 815     


Glu Asp Phe Ile Met Ala Lys Ala Tyr Leu Ala Glu His Asp Val Ala 
            820                 825                 830         


Ile Lys Lys Ala Asn Glu Asp Ile Ile Arg Asn Arg Arg Tyr Thr Glu 
        835                 840                 845             


Asp Lys Phe Phe Leu Ser Leu Ser Tyr Thr Lys Asn Ala Asp Ile Ser 
    850                 855                 860                 


Ala Arg Thr Leu Asp Tyr Ile Asn Asp Lys Val Glu Glu Asp Thr Gln 
865                 870                 875                 880 


Asp Ser Arg Met Ala Val Ile Val Thr Arg Asn Leu Lys Asp Leu Thr 
                885                 890                 895     


Tyr Val Ala Val Val Asp Glu Lys Asn Asn Val Leu Glu Glu Lys Ser 
            900                 905                 910         


Leu Asn Glu Ile Asp Gly Val Asn Tyr Arg Glu Leu Leu Lys Glu Arg 
        915                 920                 925             


Thr Lys Ile Lys Tyr His Asp Lys Thr Arg Leu Trp Gln Tyr Asp Val 
    930                 935                 940                 


Ser Ser Lys Gly Leu Lys Glu Ala Tyr Val Glu Leu Ala Val Thr Gln 
945                 950                 955                 960 


Ile Ser Lys Leu Ala Thr Lys Tyr Asn Ala Val Val Val Val Glu Ser 
                965                 970                 975     


Met Ser Ser Thr Phe Lys Asp Lys Phe Ser Phe Leu Asp Glu Gln Ile 
            980                 985                 990         


Phe Lys Ala Phe Glu Ala Arg Leu  Cys Ala Arg Met Ser  Asp Leu Ser 
        995                 1000                 1005             


Phe Asn  Thr Ile Lys Glu Gly  Glu Ala Gly Ser Ile  Ser Asn Pro 
    1010                 1015                 1020             


Ile Gln  Val Ser Asn Asn Asn  Gly Asn Ser Tyr Gln  Asp Gly Val 
    1025                 1030                 1035             


Ile Tyr  Phe Leu Asn Asn Ala  Tyr Thr Arg Thr Leu  Cys Pro Asp 
    1040                 1045                 1050             


Thr Gly  Phe Val Asp Val Phe  Asp Lys Thr Arg Leu  Ile Thr Met 
    1055                 1060                 1065             


Gln Ser  Lys Arg Gln Phe Phe  Ala Lys Met Lys Asp  Ile Arg Ile 
    1070                 1075                 1080             


Asp Asp  Gly Glu Met Leu Phe  Thr Phe Asn Leu Glu  Glu Tyr Pro 
    1085                 1090                 1095             


Thr Lys  Arg Leu Leu Asp Arg  Lys Glu Trp Thr Val  Lys Ile Ala 
    1100                 1105                 1110             


Gly Asp  Gly Ser Tyr Phe Asp  Lys Asp Lys Gly Glu  Tyr Val Tyr 
    1115                 1120                 1125             


Val Asn  Asp Ile Val Arg Glu  Gln Ile Ile Pro Ala  Leu Leu Glu 
    1130                 1135                 1140             


Asp Lys  Ala Val Phe Asp Gly  Asn Met Ala Glu Lys  Phe Leu Asp 
    1145                 1150                 1155             


Lys Thr  Ala Ile Ser Gly Lys  Ser Val Glu Leu Ile  Tyr Lys Trp 
    1160                 1165                 1170             


Phe Ala  Asn Ala Leu Tyr Gly  Ile Ile Thr Lys Lys  Asp Gly Glu 
    1175                 1180                 1185             


Lys Ile  Tyr Arg Ser Pro Ile  Thr Gly Thr Glu Ile  Asp Val Ser 
    1190                 1195                 1200             


Lys Asn  Thr Thr Tyr Asn Phe  Gly Lys Lys Phe Met  Phe Lys Gln 
    1205                 1210                 1215             


Glu Tyr  Arg Gly Asp Gly Asp  Phe Leu Asp Ala Phe  Leu Asn Tyr 
    1220                 1225                 1230             


Met Gln  Ala Gln Asp Ile Ala  Val 
    1235                 1240     


<210>  19
<211>  1238
<212>  PRT
<213>  Candidatus Methanoplasma termitum

<400>  19

Met Asn Asn Tyr Asp Glu Phe Thr Lys Leu Tyr Pro Ile Gln Lys Thr 
1               5                   10                  15      


Ile Arg Phe Glu Leu Lys Pro Gln Gly Arg Thr Met Glu His Leu Glu 
            20                  25                  30          


Thr Phe Asn Phe Phe Glu Glu Asp Arg Asp Arg Ala Glu Lys Tyr Lys 
        35                  40                  45              


Ile Leu Lys Glu Ala Ile Asp Glu Tyr His Lys Lys Phe Ile Asp Glu 
    50                  55                  60                  


His Leu Thr Asn Met Ser Leu Asp Trp Asn Ser Leu Lys Gln Ile Ser 
65                  70                  75                  80  


Glu Lys Tyr Tyr Lys Ser Arg Glu Glu Lys Asp Lys Lys Val Phe Leu 
                85                  90                  95      


Ser Glu Gln Lys Arg Met Arg Gln Glu Ile Val Ser Glu Phe Lys Lys 
            100                 105                 110         


Asp Asp Arg Phe Lys Asp Leu Phe Ser Lys Lys Leu Phe Ser Glu Leu 
        115                 120                 125             


Leu Lys Glu Glu Ile Tyr Lys Lys Gly Asn His Gln Glu Ile Asp Ala 
    130                 135                 140                 


Leu Lys Ser Phe Asp Lys Phe Ser Gly Tyr Phe Ile Gly Leu His Glu 
145                 150                 155                 160 


Asn Arg Lys Asn Met Tyr Ser Asp Gly Asp Glu Ile Thr Ala Ile Ser 
                165                 170                 175     


Asn Arg Ile Val Asn Glu Asn Phe Pro Lys Phe Leu Asp Asn Leu Gln 
            180                 185                 190         


Lys Tyr Gln Glu Ala Arg Lys Lys Tyr Pro Glu Trp Ile Ile Lys Ala 
        195                 200                 205             


Glu Ser Ala Leu Val Ala His Asn Ile Lys Met Asp Ile Val Phe Ser 
    210                 215                 220                 


Leu Glu Tyr Phe Asn Lys Val Leu Asn Gln Glu Gly Ile Gln Arg Tyr 
225                 230                 235                 240 


Asn Leu Ala Leu Gly Gly Tyr Val Thr Lys Ser Gly Glu Lys Met Met 
                245                 250                 255     


Gly Leu Asn Asp Ala Leu Asn Leu Ala His Gln Ser Glu Lys Ser Ser 
            260                 265                 270         


Lys Gly Arg Ile His Met Thr Pro Leu Phe Lys Gln Ile Leu Ser Glu 
        275                 280                 285             


Lys Glu Ser Phe Ser Tyr Ile Pro Asp Val Phe Thr Glu Asp Ser Gln 
    290                 295                 300                 


Leu Leu Pro Ser Ile Gly Gly Phe Phe Ala Gln Ile Glu Asn Asp Lys 
305                 310                 315                 320 


Asp Gly Asn Ile Phe Asp Arg Ala Leu Glu Leu Ile Ser Ser Tyr Ala 
                325                 330                 335     


Glu Tyr Asp Thr Glu Arg Ile Tyr Ile Arg Gln Ala Asp Ile Asn Arg 
            340                 345                 350         


Val Ser Asn Val Ile Phe Gly Glu Trp Gly Thr Leu Gly Gly Leu Met 
        355                 360                 365             


Arg Glu Tyr Lys Ala Asp Ser Ile Asn Asp Ile Asn Leu Glu Arg Thr 
    370                 375                 380                 


Cys Lys Lys Val Asp Lys Trp Leu Asp Ser Lys Glu Phe Ala Leu Ser 
385                 390                 395                 400 


Asp Val Leu Glu Ala Ile Asp Arg Thr Gly Asn Asn Asp Ala Phe Asn 
                405                 410                 415     


Glu Tyr Ile Ser Lys Met Arg Thr Ala Arg Glu Lys Ile Asp Ala Ala 
            420                 425                 430         


Arg Lys Glu Met Lys Phe Ile Ser Glu Lys Ile Ser Gly Asp Glu Glu 
        435                 440                 445             


Ser Ile His Ile Ile Lys Thr Leu Leu Asp Ser Val Gln Gln Phe Leu 
    450                 455                 460                 


His Phe Phe Asn Leu Phe Lys Ala Arg Gln Asp Ile Pro Leu Asp Gly 
465                 470                 475                 480 


Ala Phe Tyr Ala Glu Phe Asp Glu Val His Ser Lys Leu Phe Ala Ile 
                485                 490                 495     


Val Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Lys Asn Asn Leu 
            500                 505                 510         


Asn Thr Lys Lys Ile Lys Leu Asn Phe Lys Asn Pro Thr Leu Ala Asn 
        515                 520                 525             


Gly Trp Asp Gln Asn Lys Val Tyr Asp Tyr Ala Ser Leu Ile Phe Leu 
    530                 535                 540                 


Arg Asp Gly Asn Tyr Tyr Leu Gly Ile Ile Asn Pro Lys Arg Lys Lys 
545                 550                 555                 560 


Asn Ile Lys Phe Glu Gln Gly Ser Gly Asn Gly Pro Phe Tyr Arg Lys 
                565                 570                 575     


Met Val Tyr Lys Gln Ile Pro Gly Pro Asn Lys Asn Leu Arg Pro Val 
            580                 585                 590         


Phe Leu Thr Ser Thr Lys Gly Lys Lys Glu Tyr Lys Pro Ser Lys Glu 
        595                 600                 605             


Ile Ile Glu Gly Tyr Glu Ala Asp Lys His Ile Arg Gly Asp Lys Phe 
    610                 615                 620                 


Asp Leu Asp Phe Cys His Lys Leu Ile Asp Phe Phe Lys Glu Ser Ile 
625                 630                 635                 640 


Glu Lys His Lys Asp Trp Ser Lys Phe Asn Phe Tyr Phe Ser Pro Thr 
                645                 650                 655     


Glu Ser Tyr Gly Asp Ile Ser Glu Phe Tyr Leu Asp Val Glu Lys Gln 
            660                 665                 670         


Gly Tyr Arg Met His Phe Glu Asn Ile Ser Ala Glu Thr Ile Asp Glu 
        675                 680                 685             


Tyr Val Glu Lys Gly Asp Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp 
    690                 695                 700                 


Phe Val Lys Ala Ala Thr Gly Lys Lys Asp Met His Thr Ile Tyr Trp 
705                 710                 715                 720 


Asn Ala Ala Phe Ser Pro Glu Asn Leu Gln Asp Val Val Val Lys Leu 
                725                 730                 735     


Asn Gly Glu Ala Glu Leu Phe Tyr Arg Asp Lys Ser Asp Ile Lys Glu 
            740                 745                 750         


Ile Val His Arg Glu Gly Glu Ile Leu Val Asn Arg Thr Tyr Asn Gly 
        755                 760                 765             


Arg Thr Pro Val Pro Asp Lys Ile His Lys Lys Leu Thr Asp Tyr His 
    770                 775                 780                 


Asn Gly Arg Thr Lys Asp Leu Gly Glu Ala Lys Glu Tyr Leu Asp Lys 
785                 790                 795                 800 


Val Arg Tyr Phe Lys Ala His Tyr Asp Ile Thr Lys Asp Arg Arg Tyr 
                805                 810                 815     


Leu Asn Asp Lys Ile Tyr Phe His Val Pro Leu Thr Leu Asn Phe Lys 
            820                 825                 830         


Ala Asn Gly Lys Lys Asn Leu Asn Lys Met Val Ile Glu Lys Phe Leu 
        835                 840                 845             


Ser Asp Glu Lys Ala His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Tyr Ser Ile Ile Asp Arg Ser Gly Lys Ile Ile Asp Gln 
865                 870                 875                 880 


Gln Ser Leu Asn Val Ile Asp Gly Phe Asp Tyr Arg Glu Lys Leu Asn 
                885                 890                 895     


Gln Arg Glu Ile Glu Met Lys Asp Ala Arg Gln Ser Trp Asn Ala Ile 
            900                 905                 910         


Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Lys Ala Val His 
        915                 920                 925             


Glu Ile Thr Lys Met Ala Ile Gln Tyr Asn Ala Ile Val Val Met Glu 
    930                 935                 940                 


Glu Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln 
945                 950                 955                 960 


Ile Tyr Gln Lys Phe Glu Asn Met Leu Ile Asp Lys Met Asn Tyr Leu 
                965                 970                 975     


Val Phe Lys Asp Ala Pro Asp Glu Ser Pro Gly Gly Val Leu Asn Ala 
            980                 985                 990         


Tyr Gln Leu Thr Asn Pro Leu Glu  Ser Phe Ala Lys Leu  Gly Lys Gln 
        995                 1000                 1005             


Thr Gly  Ile Leu Phe Tyr Val  Pro Ala Ala Tyr Thr  Ser Lys Ile 
    1010                 1015                 1020             


Asp Pro  Thr Thr Gly Phe Val  Asn Leu Phe Asn Thr  Ser Ser Lys 
    1025                 1030                 1035             


Thr Asn  Ala Gln Glu Arg Lys  Glu Phe Leu Gln Lys  Phe Glu Ser 
    1040                 1045                 1050             


Ile Ser  Tyr Ser Ala Lys Asp  Gly Gly Ile Phe Ala  Phe Ala Phe 
    1055                 1060                 1065             


Asp Tyr  Arg Lys Phe Gly Thr  Ser Lys Thr Asp His  Lys Asn Val 
    1070                 1075                 1080             


Trp Thr  Ala Tyr Thr Asn Gly  Glu Arg Met Arg Tyr  Ile Lys Glu 
    1085                 1090                 1095             


Lys Lys  Arg Asn Glu Leu Phe  Asp Pro Ser Lys Glu  Ile Lys Glu 
    1100                 1105                 1110             


Ala Leu  Thr Ser Ser Gly Ile  Lys Tyr Asp Gly Gly  Gln Asn Ile 
    1115                 1120                 1125             


Leu Pro  Asp Ile Leu Arg Ser  Asn Asn Asn Gly Leu  Ile Tyr Thr 
    1130                 1135                 1140             


Met Tyr  Ser Ser Phe Ile Ala  Ala Ile Gln Met Arg  Val Tyr Asp 
    1145                 1150                 1155             


Gly Lys  Glu Asp Tyr Ile Ile  Ser Pro Ile Lys Asn  Ser Lys Gly 
    1160                 1165                 1170             


Glu Phe  Phe Arg Thr Asp Pro  Lys Arg Arg Glu Leu  Pro Ile Asp 
    1175                 1180                 1185             


Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Arg  Gly Glu Leu 
    1190                 1195                 1200             


Thr Met  Arg Ala Ile Ala Glu  Lys Phe Asp Pro Asp  Ser Glu Lys 
    1205                 1210                 1215             


Met Ala  Lys Leu Glu Leu Lys  His Lys Asp Trp Phe  Glu Phe Met 
    1220                 1225                 1230             


Gln Thr  Arg Gly Asp 
    1235             


<210>  20
<211>  1281
<212>  PRT
<213>  Eubacterium eligens

<400>  20

Met Asn Gly Asn Arg Ser Ile Val Tyr Arg Glu Phe Val Gly Val Ile 
1               5                   10                  15      


Pro Val Ala Lys Thr Leu Arg Asn Glu Leu Arg Pro Val Gly His Thr 
            20                  25                  30          


Gln Glu His Ile Ile Gln Asn Gly Leu Ile Gln Glu Asp Glu Leu Arg 
        35                  40                  45              


Gln Glu Lys Ser Thr Glu Leu Lys Asn Ile Met Asp Asp Tyr Tyr Arg 
    50                  55                  60                  


Glu Tyr Ile Asp Lys Ser Leu Ser Gly Val Thr Asp Leu Asp Phe Thr 
65                  70                  75                  80  


Leu Leu Phe Glu Leu Met Asn Leu Val Gln Ser Ser Pro Ser Lys Asp 
                85                  90                  95      


Asn Lys Lys Ala Leu Glu Lys Glu Gln Ser Lys Met Arg Glu Gln Ile 
            100                 105                 110         


Cys Thr His Leu Gln Ser Asp Ser Asn Tyr Lys Asn Ile Phe Asn Ala 
        115                 120                 125             


Lys Leu Leu Lys Glu Ile Leu Pro Asp Phe Ile Lys Asn Tyr Asn Gln 
    130                 135                 140                 


Tyr Asp Val Lys Asp Lys Ala Gly Lys Leu Glu Thr Leu Ala Leu Phe 
145                 150                 155                 160 


Asn Gly Phe Ser Thr Tyr Phe Thr Asp Phe Phe Glu Lys Arg Lys Asn 
                165                 170                 175     


Val Phe Thr Lys Glu Ala Val Ser Thr Ser Ile Ala Tyr Arg Ile Val 
            180                 185                 190         


His Glu Asn Ser Leu Ile Phe Leu Ala Asn Met Thr Ser Tyr Lys Lys 
        195                 200                 205             


Ile Ser Glu Lys Ala Leu Asp Glu Ile Glu Val Ile Glu Lys Asn Asn 
    210                 215                 220                 


Gln Asp Lys Met Gly Asp Trp Glu Leu Asn Gln Ile Phe Asn Pro Asp 
225                 230                 235                 240 


Phe Tyr Asn Met Val Leu Ile Gln Ser Gly Ile Asp Phe Tyr Asn Glu 
                245                 250                 255     


Ile Cys Gly Val Val Asn Ala His Met Asn Leu Tyr Cys Gln Gln Thr 
            260                 265                 270         


Lys Asn Asn Tyr Asn Leu Phe Lys Met Arg Lys Leu His Lys Gln Ile 
        275                 280                 285             


Leu Ala Tyr Thr Ser Thr Ser Phe Glu Val Pro Lys Met Phe Glu Asp 
    290                 295                 300                 


Asp Met Ser Val Tyr Asn Ala Val Asn Ala Phe Ile Asp Glu Thr Glu 
305                 310                 315                 320 


Lys Gly Asn Ile Ile Gly Lys Leu Lys Asp Ile Val Asn Lys Tyr Asp 
                325                 330                 335     


Glu Leu Asp Glu Lys Arg Ile Tyr Ile Ser Lys Asp Phe Tyr Glu Thr 
            340                 345                 350         


Leu Ser Cys Phe Met Ser Gly Asn Trp Asn Leu Ile Thr Gly Cys Val 
        355                 360                 365             


Glu Asn Phe Tyr Asp Glu Asn Ile His Ala Lys Gly Lys Ser Lys Glu 
    370                 375                 380                 


Glu Lys Val Lys Lys Ala Val Lys Glu Asp Lys Tyr Lys Ser Ile Asn 
385                 390                 395                 400 


Asp Val Asn Asp Leu Val Glu Lys Tyr Ile Asp Glu Lys Glu Arg Asn 
                405                 410                 415     


Glu Phe Lys Asn Ser Asn Ala Lys Gln Tyr Ile Arg Glu Ile Ser Asn 
            420                 425                 430         


Ile Ile Thr Asp Thr Glu Thr Ala His Leu Glu Tyr Asp Asp His Ile 
        435                 440                 445             


Ser Leu Ile Glu Ser Glu Glu Lys Ala Asp Glu Met Lys Lys Arg Leu 
    450                 455                 460                 


Asp Met Tyr Met Asn Met Tyr His Trp Ala Lys Ala Phe Ile Val Asp 
465                 470                 475                 480 


Glu Val Leu Asp Arg Asp Glu Met Phe Tyr Ser Asp Ile Asp Asp Ile 
                485                 490                 495     


Tyr Asn Ile Leu Glu Asn Ile Val Pro Leu Tyr Asn Arg Val Arg Asn 
            500                 505                 510         


Tyr Val Thr Gln Lys Pro Tyr Asn Ser Lys Lys Ile Lys Leu Asn Phe 
        515                 520                 525             


Gln Ser Pro Thr Leu Ala Asn Gly Trp Ser Gln Ser Lys Glu Phe Asp 
    530                 535                 540                 


Asn Asn Ala Ile Ile Leu Ile Arg Asp Asn Lys Tyr Tyr Leu Ala Ile 
545                 550                 555                 560 


Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Ile Gln Gly Asn Ser 
                565                 570                 575     


Asp Lys Lys Asn Asp Asn Asp Tyr Lys Lys Met Val Tyr Asn Leu Leu 
            580                 585                 590         


Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Leu Ser Lys Lys Gly 
        595                 600                 605             


Ile Glu Thr Phe Lys Pro Ser Asp Tyr Ile Ile Ser Gly Tyr Asn Ala 
    610                 615                 620                 


His Lys His Ile Lys Thr Ser Glu Asn Phe Asp Ile Ser Phe Cys Arg 
625                 630                 635                 640 


Asp Leu Ile Asp Tyr Phe Lys Asn Ser Ile Glu Lys His Ala Glu Trp 
                645                 650                 655     


Arg Lys Tyr Glu Phe Lys Phe Ser Ala Thr Asp Ser Tyr Ser Asp Ile 
            660                 665                 670         


Ser Glu Phe Tyr Arg Glu Val Glu Met Gln Gly Tyr Arg Ile Asp Trp 
        675                 680                 685             


Thr Tyr Ile Ser Glu Ala Asp Ile Asn Lys Leu Asp Glu Glu Gly Lys 
    690                 695                 700                 


Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Glu Asn Ser Thr 
705                 710                 715                 720 


Gly Lys Glu Asn Leu His Thr Met Tyr Phe Lys Asn Ile Phe Ser Glu 
                725                 730                 735     


Glu Asn Leu Asp Lys Ile Ile Lys Leu Asn Gly Gln Ala Glu Leu Phe 
            740                 745                 750         


Tyr Arg Arg Ala Ser Val Lys Asn Pro Val Lys His Lys Lys Asp Ser 
        755                 760                 765             


Val Leu Val Asn Lys Thr Tyr Lys Asn Gln Leu Asp Asn Gly Asp Val 
    770                 775                 780                 


Val Arg Ile Pro Ile Pro Asp Asp Ile Tyr Asn Glu Ile Tyr Lys Met 
785                 790                 795                 800 


Tyr Asn Gly Tyr Ile Lys Glu Ser Asp Leu Ser Glu Ala Ala Lys Glu 
                805                 810                 815     


Tyr Leu Asp Lys Val Glu Val Arg Thr Ala Gln Lys Asp Ile Val Lys 
            820                 825                 830         


Asp Tyr Arg Tyr Thr Val Asp Lys Tyr Phe Ile His Thr Pro Ile Thr 
        835                 840                 845             


Ile Asn Tyr Lys Val Thr Ala Arg Asn Asn Val Asn Asp Met Val Val 
    850                 855                 860                 


Lys Tyr Ile Ala Gln Asn Asp Asp Ile His Val Ile Gly Ile Asp Arg 
865                 870                 875                 880 


Gly Glu Arg Asn Leu Ile Tyr Ile Ser Val Ile Asp Ser His Gly Asn 
                885                 890                 895     


Ile Val Lys Gln Lys Ser Tyr Asn Ile Leu Asn Asn Tyr Asp Tyr Lys 
            900                 905                 910         


Lys Lys Leu Val Glu Lys Glu Lys Thr Arg Glu Tyr Ala Arg Lys Asn 
        915                 920                 925             


Trp Lys Ser Ile Gly Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser 
    930                 935                 940                 


Gly Val Val His Glu Ile Ala Met Leu Ile Val Glu Tyr Asn Ala Ile 
945                 950                 955                 960 


Ile Ala Met Glu Asp Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys 
                965                 970                 975     


Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn Lys 
            980                 985                 990         


Leu Asn Tyr Phe Ala Ser Lys Glu  Lys Ser Val Asp Glu  Pro Gly Gly 
        995                 1000                 1005             


Leu Leu  Lys Gly Tyr Gln Leu  Thr Tyr Val Pro Asp  Asn Ile Lys 
    1010                 1015                 1020             


Asn Leu  Gly Lys Gln Cys Gly  Val Ile Phe Tyr Val  Pro Ala Ala 
    1025                 1030                 1035             


Phe Thr  Ser Lys Ile Asp Pro  Ser Thr Gly Phe Ile  Ser Ala Phe 
    1040                 1045                 1050             


Asn Phe  Lys Ser Ile Ser Thr  Asn Ala Ser Arg Lys  Gln Phe Phe 
    1055                 1060                 1065             


Met Gln  Phe Asp Glu Ile Arg  Tyr Cys Ala Glu Lys  Asp Met Phe 
    1070                 1075                 1080             


Ser Phe  Gly Phe Asp Tyr Asn  Asn Phe Asp Thr Tyr  Asn Ile Thr 
    1085                 1090                 1095             


Met Gly  Lys Thr Gln Trp Thr  Val Tyr Thr Asn Gly  Glu Arg Leu 
    1100                 1105                 1110             


Gln Ser  Glu Phe Asn Asn Ala  Arg Arg Thr Gly Lys  Thr Lys Ser 
    1115                 1120                 1125             


Ile Asn  Leu Thr Glu Thr Ile  Lys Leu Leu Leu Glu  Asp Asn Glu 
    1130                 1135                 1140             


Ile Asn  Tyr Ala Asp Gly His  Asp Ile Arg Ile Asp  Met Glu Lys 
    1145                 1150                 1155             


Met Asp  Glu Asp Lys Lys Ser  Glu Phe Phe Ala Gln  Leu Leu Ser 
    1160                 1165                 1170             


Leu Tyr  Lys Leu Thr Val Gln  Met Arg Asn Ser Tyr  Thr Glu Ala 
    1175                 1180                 1185             


Glu Glu  Gln Glu Asn Gly Ile  Ser Tyr Asp Lys Ile  Ile Ser Pro 
    1190                 1195                 1200             


Val Ile  Asn Asp Glu Gly Glu  Phe Phe Asp Ser Asp  Asn Tyr Lys 
    1205                 1210                 1215             


Glu Ser  Asp Asp Lys Glu Cys  Lys Met Pro Lys Asp  Ala Asp Ala 
    1220                 1225                 1230             


Asn Gly  Ala Tyr Cys Ile Ala  Leu Lys Gly Leu Tyr  Glu Val Leu 
    1235                 1240                 1245             


Lys Ile  Lys Ser Glu Trp Thr  Glu Asp Gly Phe Asp  Arg Asn Cys 
    1250                 1255                 1260             


Leu Lys  Leu Pro His Ala Glu  Trp Leu Asp Phe Ile  Gln Asn Lys 
    1265                 1270                 1275             


Arg Tyr  Glu 
    1280     


<210>  21
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  21

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Val Asn Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  22
<211>  1206
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  22

Met Tyr Tyr Glu Ser Leu Thr Lys Gln Tyr Pro Val Ser Lys Thr Ile 
1               5                   10                  15      


Arg Asn Glu Leu Ile Pro Ile Gly Lys Thr Leu Asp Asn Ile Arg Gln 
            20                  25                  30          


Asn Asn Ile Leu Glu Ser Asp Val Lys Arg Lys Gln Asn Tyr Glu His 
        35                  40                  45              


Val Lys Gly Ile Leu Asp Glu Tyr His Lys Gln Leu Ile Asn Glu Ala 
    50                  55                  60                  


Leu Asp Asn Cys Thr Leu Pro Ser Leu Lys Ile Ala Ala Glu Ile Tyr 
65                  70                  75                  80  


Leu Lys Asn Gln Lys Glu Val Ser Asp Arg Glu Asp Phe Asn Lys Thr 
                85                  90                  95      


Gln Asp Leu Leu Arg Lys Glu Val Val Glu Lys Leu Lys Ala His Glu 
            100                 105                 110         


Asn Phe Thr Lys Ile Gly Lys Lys Asp Ile Leu Asp Leu Leu Glu Lys 
        115                 120                 125             


Leu Pro Ser Ile Ser Glu Asp Asp Tyr Asn Ala Leu Glu Ser Phe Arg 
    130                 135                 140                 


Asn Phe Tyr Thr Tyr Phe Thr Ser Tyr Asn Lys Val Arg Glu Asn Leu 
145                 150                 155                 160 


Tyr Ser Asp Lys Glu Lys Ser Ser Thr Val Ala Tyr Arg Leu Ile Asn 
                165                 170                 175     


Glu Asn Phe Pro Lys Phe Leu Asp Asn Val Lys Ser Tyr Arg Phe Val 
            180                 185                 190         


Lys Thr Ala Gly Ile Leu Ala Asp Gly Leu Gly Glu Glu Glu Gln Asp 
        195                 200                 205             


Ser Leu Phe Ile Val Glu Thr Phe Asn Lys Thr Leu Thr Gln Asp Gly 
    210                 215                 220                 


Ile Asp Thr Tyr Asn Ser Gln Val Gly Lys Ile Asn Ser Ser Ile Asn 
225                 230                 235                 240 


Leu Tyr Asn Gln Lys Asn Gln Lys Ala Asn Gly Phe Arg Lys Ile Pro 
                245                 250                 255     


Lys Met Lys Met Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Glu Ser 
            260                 265                 270         


Phe Ile Asp Glu Phe Gln Ser Asp Glu Val Leu Ile Asp Asn Val Glu 
        275                 280                 285             


Ser Tyr Gly Ser Val Leu Ile Glu Ser Leu Lys Ser Ser Lys Val Ser 
    290                 295                 300                 


Ala Phe Phe Asp Ala Leu Arg Glu Ser Lys Gly Lys Asn Val Tyr Val 
305                 310                 315                 320 


Lys Asn Asp Leu Ala Lys Thr Ala Met Ser Val Ile Val Phe Glu Asn 
                325                 330                 335     


Trp Arg Thr Phe Asp Asp Leu Leu Asn Gln Glu Tyr Asp Leu Ala Asn 
            340                 345                 350         


Glu Asn Lys Lys Lys Asp Asp Lys Tyr Phe Glu Lys Arg Gln Lys Glu 
        355                 360                 365             


Leu Lys Lys Asn Lys Ser Tyr Ser Leu Glu His Leu Cys Asn Leu Ser 
    370                 375                 380                 


Glu Asp Ser Cys Asn Leu Ile Glu Asn Tyr Ile His Gln Ile Ser Asp 
385                 390                 395                 400 


Asp Ile Glu Asn Ile Ile Ile Asn Asn Glu Thr Phe Leu Arg Ile Val 
                405                 410                 415     


Ile Asn Glu His Asp Arg Ser Arg Lys Leu Ala Lys Asn Arg Lys Ala 
            420                 425                 430         


Val Lys Ala Ile Lys Asp Phe Leu Asp Ser Ile Lys Val Leu Glu Arg 
        435                 440                 445             


Glu Leu Lys Leu Ile Asn Ser Ser Gly Gln Glu Leu Glu Lys Asp Leu 
    450                 455                 460                 


Ile Val Tyr Ser Ala His Glu Glu Leu Leu Val Glu Leu Lys Gln Val 
465                 470                 475                 480 


Asp Ser Leu Tyr Asn Met Thr Arg Asn Tyr Leu Thr Lys Lys Pro Phe 
                485                 490                 495     


Ser Thr Glu Lys Val Lys Leu Asn Phe Asn Arg Ser Thr Leu Leu Asn 
            500                 505                 510         


Gly Trp Asp Arg Asn Lys Glu Thr Asp Asn Leu Gly Val Leu Leu Leu 
        515                 520                 525             


Lys Asp Gly Lys Tyr Tyr Leu Gly Ile Met Asn Thr Ser Ala Asn Lys 
    530                 535                 540                 


Ala Phe Val Asn Pro Pro Val Ala Lys Thr Glu Lys Val Phe Lys Lys 
545                 550                 555                 560 


Val Asp Tyr Lys Leu Leu Pro Val Pro Asn Gln Met Leu Pro Lys Val 
                565                 570                 575     


Phe Phe Ala Lys Ser Asn Ile Asp Phe Tyr Asn Pro Ser Ser Glu Ile 
            580                 585                 590         


Tyr Ser Asn Tyr Lys Lys Gly Thr His Lys Lys Gly Asn Met Phe Ser 
        595                 600                 605             


Leu Glu Asp Cys His Asn Leu Ile Asp Phe Phe Lys Glu Ser Ile Ser 
    610                 615                 620                 


Lys His Glu Asp Trp Ser Lys Phe Gly Phe Lys Phe Asp Thr Gln Ala 
625                 630                 635                 640 


Ser Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val Glu Lys Gln Gly 
                645                 650                 655     


Tyr Lys Leu Thr Tyr Thr Asp Ile Asp Glu Thr Tyr Ile Asn Asp Leu 
            660                 665                 670         


Ile Glu Arg Asn Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
        675                 680                 685             


Ser Met Tyr Ser Lys Gly Lys Leu Asn Leu His Thr Leu Tyr Phe Met 
    690                 695                 700                 


Met Leu Phe Asp Gln Arg Asn Ile Asp Asp Val Val Tyr Lys Leu Asn 
705                 710                 715                 720 


Gly Glu Ala Glu Val Phe Tyr Arg Pro Ala Ser Ile Ser Glu Asp Glu 
                725                 730                 735     


Leu Ile Ile His Lys Ala Gly Glu Glu Ile Lys Asn Lys Asn Pro Asn 
            740                 745                 750         


Arg Ala Arg Thr Lys Glu Thr Ser Thr Phe Ser Tyr Asp Ile Val Lys 
        755                 760                 765             


Asp Lys Arg Tyr Ser Lys Asp Lys Phe Thr Leu His Ile Pro Ile Thr 
    770                 775                 780                 


Met Asn Phe Gly Val Asp Glu Val Lys Arg Phe Asn Asp Ala Val Asn 
785                 790                 795                 800 


Ser Ala Ile Arg Ile Asp Glu Asn Val Asn Val Ile Gly Ile Asp Arg 
                805                 810                 815     


Gly Glu Arg Asn Leu Leu Tyr Val Val Val Ile Asp Ser Lys Gly Asn 
            820                 825                 830         


Ile Leu Glu Gln Ile Ser Leu Asn Ser Ile Ile Asn Lys Glu Tyr Asp 
        835                 840                 845             


Ile Glu Thr Asp Tyr His Ala Leu Leu Asp Glu Arg Glu Gly Gly Arg 
    850                 855                 860                 


Asp Lys Ala Arg Lys Asp Trp Asn Thr Val Glu Asn Ile Arg Asp Leu 
865                 870                 875                 880 


Lys Ala Gly Leu Tyr Leu Gln Val Val Asn Val Val Ala Lys Leu Val 
                885                 890                 895     


Leu Lys Tyr Asn Ala Ile Ile Cys Leu Glu Asp Leu Asn Phe Gly Phe 
            900                 905                 910         


Lys Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu 
        915                 920                 925             


Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Ile Asp Lys Ser Arg 
    930                 935                 940                 


Glu Gln Thr Ser Pro Lys Glu Leu Gly Gly Ala Leu Asn Ala Leu Gln 
945                 950                 955                 960 


Leu Thr Ser Lys Phe Lys Ser Phe Lys Glu Leu Gly Lys Gln Ser Gly 
                965                 970                 975     


Val Ile Tyr Tyr Val Pro Ala Tyr Leu Thr Ser Lys Ile Asp Pro Thr 
            980                 985                 990         


Thr Gly Phe Ala Asn Leu Phe Tyr  Met Lys Cys Glu Asn  Val Glu Lys 
        995                 1000                 1005             


Ser Lys  Arg Phe Phe Asp Gly  Phe Asp Phe Ile Arg  Phe Asn Ala 
    1010                 1015                 1020             


Leu Glu  Asn Val Phe Glu Phe  Gly Phe Asp Tyr Arg  Ser Phe Thr 
    1025                 1030                 1035             


Gln Arg  Ala Cys Gly Ile Asn  Ser Lys Trp Thr Val  Cys Thr Asn 
    1040                 1045                 1050             


Gly Glu  Arg Ile Ile Lys Tyr  Arg Asn Pro Asp Lys  Asn Asn Met 
    1055                 1060                 1065             


Phe Asp  Glu Lys Val Val Val  Val Thr Asp Glu Met  Lys Asn Leu 
    1070                 1075                 1080             


Phe Glu  Gln Tyr Lys Ile Pro  Tyr Glu Asp Gly Arg  Asn Val Lys 
    1085                 1090                 1095             


Asp Met  Ile Ile Ser Asn Glu  Glu Ala Glu Phe Tyr  Arg Arg Leu 
    1100                 1105                 1110             


Tyr Arg  Leu Leu Gln Gln Thr  Leu Gln Met Arg Asn  Ser Thr Ser 
    1115                 1120                 1125             


Asp Gly  Thr Arg Asp Tyr Ile  Ile Ser Pro Val Lys  Asn Lys Arg 
    1130                 1135                 1140             


Glu Ala  Tyr Phe Asn Ser Glu  Leu Ser Asp Gly Ser  Val Pro Lys 
    1145                 1150                 1155             


Asp Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Leu 
    1160                 1165                 1170             


Trp Val  Leu Glu Gln Ile Arg  Gln Lys Ser Glu Gly  Glu Lys Ile 
    1175                 1180                 1185             


Asn Leu  Ala Met Thr Asn Ala  Glu Trp Leu Glu Tyr  Ala Gln Thr 
    1190                 1195                 1200             


His Leu  Leu 
    1205     


<210>  23
<211>  1233
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  23

Met Asp Tyr Gly Asn Gly Gln Phe Glu Arg Arg Ala Pro Leu Thr Lys 
1               5                   10                  15      


Thr Ile Thr Leu Arg Leu Lys Pro Ile Gly Glu Thr Arg Glu Thr Ile 
            20                  25                  30          


Arg Glu Gln Lys Leu Leu Glu Gln Asp Ala Ala Phe Arg Lys Leu Val 
        35                  40                  45              


Glu Thr Val Thr Pro Ile Val Asp Asp Cys Ile Arg Lys Ile Ala Asp 
    50                  55                  60                  


Asn Ala Leu Cys His Phe Gly Thr Glu Tyr Asp Phe Ser Cys Leu Gly 
65                  70                  75                  80  


Asn Ala Ile Ser Lys Asn Asp Ser Lys Ala Ile Lys Lys Glu Thr Glu 
                85                  90                  95      


Lys Val Glu Lys Leu Leu Ala Lys Val Leu Thr Glu Asn Leu Pro Asp 
            100                 105                 110         


Gly Leu Arg Lys Val Asn Asp Ile Asn Ser Ala Ala Phe Ile Gln Asp 
        115                 120                 125             


Thr Leu Thr Ser Phe Val Gln Asp Asp Ala Asp Lys Arg Val Leu Ile 
    130                 135                 140                 


Gln Glu Leu Lys Gly Lys Thr Val Leu Met Gln Arg Phe Leu Thr Thr 
145                 150                 155                 160 


Arg Ile Thr Ala Leu Thr Val Trp Leu Pro Asp Arg Val Phe Glu Asn 
                165                 170                 175     


Phe Asn Ile Phe Ile Glu Asn Ala Glu Lys Met Arg Ile Leu Leu Asp 
            180                 185                 190         


Ser Pro Leu Asn Glu Lys Ile Met Lys Phe Asp Pro Asp Ala Glu Gln 
        195                 200                 205             


Tyr Ala Ser Leu Glu Phe Tyr Gly Gln Cys Leu Ser Gln Lys Asp Ile 
    210                 215                 220                 


Asp Ser Tyr Asn Leu Ile Ile Ser Gly Ile Tyr Ala Asp Asp Glu Val 
225                 230                 235                 240 


Lys Asn Pro Gly Ile Asn Glu Ile Val Lys Glu Tyr Asn Gln Gln Ile 
                245                 250                 255     


Arg Gly Asp Lys Asp Glu Ser Pro Leu Pro Lys Leu Lys Lys Leu His 
            260                 265                 270         


Lys Gln Ile Leu Met Pro Val Glu Lys Ala Phe Phe Val Arg Val Leu 
        275                 280                 285             


Ser Asn Asp Ser Asp Ala Arg Ser Ile Leu Glu Lys Ile Leu Lys Asp 
    290                 295                 300                 


Thr Glu Met Leu Pro Ser Lys Ile Ile Glu Ala Met Lys Glu Ala Asp 
305                 310                 315                 320 


Ala Gly Asp Ile Ala Val Tyr Gly Ser Arg Leu His Glu Leu Ser His 
                325                 330                 335     


Val Ile Tyr Gly Asp His Gly Lys Leu Ser Gln Ile Ile Tyr Asp Lys 
            340                 345                 350         


Glu Ser Lys Arg Ile Ser Glu Leu Met Glu Thr Leu Ser Pro Lys Glu 
        355                 360                 365             


Arg Lys Glu Ser Lys Lys Arg Leu Glu Gly Leu Glu Glu His Ile Arg 
    370                 375                 380                 


Lys Ser Thr Tyr Thr Phe Asp Glu Leu Asn Arg Tyr Ala Glu Lys Asn 
385                 390                 395                 400 


Val Met Ala Ala Tyr Ile Ala Ala Val Glu Glu Ser Cys Ala Glu Ile 
                405                 410                 415     


Met Arg Lys Glu Lys Asp Leu Arg Thr Leu Leu Ser Lys Glu Asp Val 
            420                 425                 430         


Lys Ile Arg Gly Asn Arg His Asn Thr Leu Ile Val Lys Asn Tyr Phe 
        435                 440                 445             


Asn Ala Trp Thr Val Phe Arg Asn Leu Ile Arg Ile Leu Arg Arg Lys 
    450                 455                 460                 


Ser Glu Ala Glu Ile Asp Ser Asp Phe Tyr Asp Val Leu Asp Asp Ser 
465                 470                 475                 480 


Val Glu Val Leu Ser Leu Thr Tyr Lys Gly Glu Asn Leu Cys Arg Ser 
                485                 490                 495     


Tyr Ile Thr Lys Lys Ile Gly Ser Asp Leu Lys Pro Glu Ile Ala Thr 
            500                 505                 510         


Tyr Gly Ser Ala Leu Arg Pro Asn Ser Arg Trp Trp Ser Pro Gly Glu 
        515                 520                 525             


Lys Phe Asn Val Lys Phe His Thr Ile Val Arg Arg Asp Gly Arg Leu 
    530                 535                 540                 


Tyr Tyr Phe Ile Leu Pro Lys Gly Ala Lys Pro Val Glu Leu Glu Asp 
545                 550                 555                 560 


Met Asp Gly Asp Ile Glu Cys Leu Gln Met Arg Lys Ile Pro Asn Pro 
                565                 570                 575     


Thr Ile Phe Leu Pro Lys Leu Val Phe Lys Asp Pro Glu Ala Phe Phe 
            580                 585                 590         


Arg Asp Asn Pro Glu Ala Asp Glu Phe Val Phe Leu Ser Gly Met Lys 
        595                 600                 605             


Ala Pro Val Thr Ile Thr Arg Glu Thr Tyr Glu Ala Tyr Arg Tyr Lys 
    610                 615                 620                 


Leu Tyr Thr Val Gly Lys Leu Arg Asp Gly Glu Val Ser Glu Glu Glu 
625                 630                 635                 640 


Tyr Lys Arg Ala Leu Leu Gln Val Leu Thr Ala Tyr Lys Glu Phe Leu 
                645                 650                 655     


Glu Asn Arg Met Ile Tyr Ala Asp Leu Asn Phe Gly Phe Lys Asp Leu 
            660                 665                 670         


Glu Glu Tyr Lys Asp Ser Ser Glu Phe Ile Lys Gln Val Glu Thr His 
        675                 680                 685             


Asn Thr Phe Met Cys Trp Ala Lys Val Ser Ser Ser Gln Leu Asp Asp 
    690                 695                 700                 


Leu Val Lys Ser Gly Asn Gly Leu Leu Phe Glu Ile Trp Ser Glu Arg 
705                 710                 715                 720 


Leu Glu Ser Tyr Tyr Lys Tyr Gly Asn Glu Lys Val Leu Arg Gly Tyr 
                725                 730                 735     


Glu Gly Val Leu Leu Ser Ile Leu Lys Asp Glu Asn Leu Val Ser Met 
            740                 745                 750         


Arg Thr Leu Leu Asn Ser Arg Pro Met Leu Val Tyr Arg Pro Lys Glu 
        755                 760                 765             


Ser Ser Lys Pro Met Val Val His Arg Asp Gly Ser Arg Val Val Asp 
    770                 775                 780                 


Arg Phe Asp Lys Asp Gly Lys Tyr Ile Pro Pro Glu Val His Asp Glu 
785                 790                 795                 800 


Leu Tyr Arg Phe Phe Asn Asn Leu Leu Ile Lys Glu Lys Leu Gly Glu 
                805                 810                 815     


Lys Ala Arg Lys Ile Leu Asp Asn Lys Lys Val Lys Val Lys Val Leu 
            820                 825                 830         


Glu Ser Glu Arg Val Lys Trp Ser Lys Phe Tyr Asp Glu Gln Phe Ala 
        835                 840                 845             


Val Thr Phe Ser Val Lys Lys Asn Ala Asp Cys Leu Asp Thr Thr Lys 
    850                 855                 860                 


Asp Leu Asn Ala Glu Val Met Glu Gln Tyr Ser Glu Ser Asn Arg Leu 
865                 870                 875                 880 


Ile Leu Ile Arg Asn Thr Thr Asp Ile Leu Tyr Tyr Leu Val Leu Asp 
                885                 890                 895     


Lys Asn Gly Lys Val Leu Lys Gln Arg Ser Leu Asn Ile Ile Asn Asp 
            900                 905                 910         


Gly Ala Arg Asp Val Asp Trp Lys Glu Arg Phe Arg Gln Val Thr Lys 
        915                 920                 925             


Asp Arg Asn Glu Gly Tyr Asn Glu Trp Asp Tyr Ser Arg Thr Ser Asn 
    930                 935                 940                 


Asp Leu Lys Glu Val Tyr Leu Asn Tyr Ala Leu Lys Glu Ile Ala Glu 
945                 950                 955                 960 


Ala Val Ile Glu Tyr Asn Ala Ile Leu Ile Ile Glu Lys Met Ser Asn 
                965                 970                 975     


Ala Phe Lys Asp Lys Tyr Ser Phe Leu Asp Asp Val Thr Phe Lys Gly 
            980                 985                 990         


Phe Glu Thr Lys Lys Leu Ala Lys  Leu Ser Asp Leu His  Phe Arg Gly 
        995                 1000                 1005             


Ile Lys  Asp Gly Glu Pro Cys  Ser Phe Thr Asn Pro  Leu Gln Leu 
    1010                 1015                 1020             


Cys Gln  Asn Asp Ser Asn Lys  Ile Leu Gln Asp Gly  Val Ile Phe 
    1025                 1030                 1035             


Met Val  Pro Asn Ser Met Thr  Arg Ser Leu Asp Pro  Asp Thr Gly 
    1040                 1045                 1050             


Phe Ile  Phe Ala Ile Asn Asp  His Asn Ile Arg Thr  Lys Lys Ala 
    1055                 1060                 1065             


Lys Leu  Asn Phe Leu Ser Lys  Phe Asp Gln Leu Lys  Val Ser Ser 
    1070                 1075                 1080             


Glu Gly  Cys Leu Ile Met Lys  Tyr Ser Gly Asp Ser  Leu Pro Thr 
    1085                 1090                 1095             


His Asn  Thr Asp Asn Arg Val  Trp Asn Cys Cys Cys  Asn His Pro 
    1100                 1105                 1110             


Ile Thr  Asn Tyr Asp Arg Glu  Thr Lys Lys Val Glu  Phe Ile Glu 
    1115                 1120                 1125             


Glu Pro  Val Glu Glu Leu Ser  Arg Val Leu Glu Glu  Asn Gly Ile 
    1130                 1135                 1140             


Glu Thr  Asp Thr Glu Leu Asn  Lys Leu Asn Glu Arg  Glu Asn Val 
    1145                 1150                 1155             


Pro Gly  Lys Val Val Asp Ala  Ile Tyr Ser Leu Val  Leu Asn Tyr 
    1160                 1165                 1170             


Leu Arg  Gly Thr Val Ser Gly  Val Ala Gly Gln Arg  Ala Val Tyr 
    1175                 1180                 1185             


Tyr Ser  Pro Val Thr Gly Lys  Lys Tyr Asp Ile Ser  Phe Ile Gln 
    1190                 1195                 1200             


Ala Met  Asn Leu Asn Arg Lys  Cys Asp Tyr Tyr Arg  Ile Gly Ser 
    1205                 1210                 1215             


Lys Glu  Arg Gly Glu Trp Thr  Asp Phe Val Ala Gln  Leu Ile Asn 
    1220                 1225                 1230             


<210>  24
<211>  1227
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  24

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Asn Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ser Asn Lys  Glu Trp Leu 
    1205                 1210                 1215             


Glu Tyr  Ala Gln Thr Ser Val  Lys His 
    1220                 1225         


<210>  25
<211>  1264
<212>  PRT
<213>  Leptospira inadai

<400>  25

Met Glu Asp Tyr Ser Gly Phe Val Asn Ile Tyr Ser Ile Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu His Ile Glu 
            20                  25                  30          


Lys Lys Gly Phe Leu Lys Lys Asp Lys Ile Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Ala Val Lys Lys Ile Ile Asp Lys Tyr His Arg Ala Tyr Ile Glu Glu 
    50                  55                  60                  


Val Phe Asp Ser Val Leu His Gln Lys Lys Lys Lys Asp Lys Thr Arg 
65                  70                  75                  80  


Phe Ser Thr Gln Phe Ile Lys Glu Ile Lys Glu Phe Ser Glu Leu Tyr 
                85                  90                  95      


Tyr Lys Thr Glu Lys Asn Ile Pro Asp Lys Glu Arg Leu Glu Ala Leu 
            100                 105                 110         


Ser Glu Lys Leu Arg Lys Met Leu Val Gly Ala Phe Lys Gly Glu Phe 
        115                 120                 125             


Ser Glu Glu Val Ala Glu Lys Tyr Asn Lys Asn Leu Phe Ser Lys Glu 
    130                 135                 140                 


Leu Ile Arg Asn Glu Ile Glu Lys Phe Cys Glu Thr Asp Glu Glu Arg 
145                 150                 155                 160 


Lys Gln Val Ser Asn Phe Lys Ser Phe Thr Thr Tyr Phe Thr Gly Phe 
                165                 170                 175     


His Ser Asn Arg Gln Asn Ile Tyr Ser Asp Glu Lys Lys Ser Thr Ala 
            180                 185                 190         


Ile Gly Tyr Arg Ile Ile His Gln Asn Leu Pro Lys Phe Leu Asp Asn 
        195                 200                 205             


Leu Lys Ile Ile Glu Ser Ile Gln Arg Arg Phe Lys Asp Phe Pro Trp 
    210                 215                 220                 


Ser Asp Leu Lys Lys Asn Leu Lys Lys Ile Asp Lys Asn Ile Lys Leu 
225                 230                 235                 240 


Thr Glu Tyr Phe Ser Ile Asp Gly Phe Val Asn Val Leu Asn Gln Lys 
                245                 250                 255     


Gly Ile Asp Ala Tyr Asn Thr Ile Leu Gly Gly Lys Ser Glu Glu Ser 
            260                 265                 270         


Gly Glu Lys Ile Gln Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Arg Gln 
        275                 280                 285             


Lys Asn Asn Ile Asp Arg Lys Asn Pro Leu Asn Val Lys Ile Leu Phe 
    290                 295                 300                 


Lys Gln Ile Leu Gly Asp Arg Glu Thr Lys Ser Phe Ile Pro Glu Ala 
305                 310                 315                 320 


Phe Pro Asp Asp Gln Ser Val Leu Asn Ser Ile Thr Glu Phe Ala Lys 
                325                 330                 335     


Tyr Leu Lys Leu Asp Lys Lys Lys Lys Ser Ile Ile Ala Glu Leu Lys 
            340                 345                 350         


Lys Phe Leu Ser Ser Phe Asn Arg Tyr Glu Leu Asp Gly Ile Tyr Leu 
        355                 360                 365             


Ala Asn Asp Asn Ser Leu Ala Ser Ile Ser Thr Phe Leu Phe Asp Asp 
    370                 375                 380                 


Trp Ser Phe Ile Lys Lys Ser Val Ser Phe Lys Tyr Asp Glu Ser Val 
385                 390                 395                 400 


Gly Asp Pro Lys Lys Lys Ile Lys Ser Pro Leu Lys Tyr Glu Lys Glu 
                405                 410                 415     


Lys Glu Lys Trp Leu Lys Gln Lys Tyr Tyr Thr Ile Ser Phe Leu Asn 
            420                 425                 430         


Asp Ala Ile Glu Ser Tyr Ser Lys Ser Gln Asp Glu Lys Arg Val Lys 
        435                 440                 445             


Ile Arg Leu Glu Ala Tyr Phe Ala Glu Phe Lys Ser Lys Asp Asp Ala 
    450                 455                 460                 


Lys Lys Gln Phe Asp Leu Leu Glu Arg Ile Glu Glu Ala Tyr Ala Ile 
465                 470                 475                 480 


Val Glu Pro Leu Leu Gly Ala Glu Tyr Pro Arg Asp Arg Asn Leu Lys 
                485                 490                 495     


Ala Asp Lys Lys Glu Val Gly Lys Ile Lys Asp Phe Leu Asp Ser Ile 
            500                 505                 510         


Lys Ser Leu Gln Phe Phe Leu Lys Pro Leu Leu Ser Ala Glu Ile Phe 
        515                 520                 525             


Asp Glu Lys Asp Leu Gly Phe Tyr Asn Gln Leu Glu Gly Tyr Tyr Glu 
    530                 535                 540                 


Glu Ile Asp Ile Ser Gly His Leu Tyr Asn Lys Val Arg Asn Tyr Leu 
545                 550                 555                 560 


Thr Gly Lys Ile Tyr Ser Lys Glu Lys Phe Lys Leu Asn Phe Glu Asn 
                565                 570                 575     


Ser Thr Leu Leu Lys Gly Trp Asp Glu Asn Arg Glu Val Ala Asn Leu 
            580                 585                 590         


Cys Val Ile Phe Arg Glu Asp Gln Lys Tyr Tyr Leu Gly Val Met Asp 
        595                 600                 605             


Lys Glu Asn Asn Thr Ile Leu Ser Asp Ile Pro Lys Val Lys Pro Asn 
    610                 615                 620                 


Glu Leu Phe Tyr Glu Lys Met Val Tyr Lys Leu Ile Pro Thr Pro His 
625                 630                 635                 640 


Met Gln Leu Pro Arg Ile Ile Phe Ser Ser Asp Asn Leu Ser Ile Tyr 
                645                 650                 655     


Asn Pro Ser Lys Ser Ile Leu Lys Ile Arg Glu Ala Lys Ser Phe Lys 
            660                 665                 670         


Glu Gly Lys Asn Phe Lys Leu Lys Asp Cys His Lys Phe Ile Asp Phe 
        675                 680                 685             


Tyr Lys Glu Ser Ile Ser Lys Asn Glu Asp Trp Ser Arg Phe Asp Phe 
    690                 695                 700                 


Lys Phe Ser Lys Thr Ser Ser Tyr Glu Asn Ile Ser Glu Phe Tyr Arg 
705                 710                 715                 720 


Glu Val Glu Arg Gln Gly Tyr Asn Leu Asp Phe Lys Lys Val Ser Lys 
                725                 730                 735     


Phe Tyr Ile Asp Ser Leu Val Glu Asp Gly Lys Leu Tyr Leu Phe Gln 
            740                 745                 750         


Ile Tyr Asn Lys Asp Phe Ser Ile Phe Ser Lys Gly Lys Pro Asn Leu 
        755                 760                 765             


His Thr Ile Tyr Phe Arg Ser Leu Phe Ser Lys Glu Asn Leu Lys Asp 
    770                 775                 780                 


Val Cys Leu Lys Leu Asn Gly Glu Ala Glu Met Phe Phe Arg Lys Lys 
785                 790                 795                 800 


Ser Ile Asn Tyr Asp Glu Lys Lys Lys Arg Glu Gly His His Pro Glu 
                805                 810                 815     


Leu Phe Glu Lys Leu Lys Tyr Pro Ile Leu Lys Asp Lys Arg Tyr Ser 
            820                 825                 830         


Glu Asp Lys Phe Gln Phe His Leu Pro Ile Ser Leu Asn Phe Lys Ser 
        835                 840                 845             


Lys Glu Arg Leu Asn Phe Asn Leu Lys Val Asn Glu Phe Leu Lys Arg 
    850                 855                 860                 


Asn Lys Asp Ile Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu 
865                 870                 875                 880 


Leu Tyr Leu Val Met Ile Asn Gln Lys Gly Glu Ile Leu Lys Gln Thr 
                885                 890                 895     


Leu Leu Asp Ser Met Gln Ser Gly Lys Gly Arg Pro Glu Ile Asn Tyr 
            900                 905                 910         


Lys Glu Lys Leu Gln Glu Lys Glu Ile Glu Arg Asp Lys Ala Arg Lys 
        915                 920                 925             


Ser Trp Gly Thr Val Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu 
    930                 935                 940                 


Ser Ile Val Ile His Gln Ile Ser Lys Leu Met Val Glu Asn Asn Ala 
945                 950                 955                 960 


Ile Val Val Leu Glu Asp Leu Asn Ile Gly Phe Lys Arg Gly Arg Gln 
                965                 970                 975     


Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp 
            980                 985                 990         


Lys Leu Asn Phe Leu Val Phe Lys  Glu Asn Lys Pro Thr  Glu Pro Gly 
        995                 1000                 1005             


Gly Val  Leu Lys Ala Tyr Gln  Leu Thr Asp Glu Phe  Gln Ser Phe 
    1010                 1015                 1020             


Glu Lys  Leu Ser Lys Gln Thr  Gly Phe Leu Phe Tyr  Val Pro Ser 
    1025                 1030                 1035             


Trp Asn  Thr Ser Lys Ile Asp  Pro Arg Thr Gly Phe  Ile Asp Phe 
    1040                 1045                 1050             


Leu His  Pro Ala Tyr Glu Asn  Ile Glu Lys Ala Lys  Gln Trp Ile 
    1055                 1060                 1065             


Asn Lys  Phe Asp Ser Ile Arg  Phe Asn Ser Lys Met  Asp Trp Phe 
    1070                 1075                 1080             


Glu Phe  Thr Ala Asp Thr Arg  Lys Phe Ser Glu Asn  Leu Met Leu 
    1085                 1090                 1095             


Gly Lys  Asn Arg Val Trp Val  Ile Cys Thr Thr Asn  Val Glu Arg 
    1100                 1105                 1110             


Tyr Phe  Thr Ser Lys Thr Ala  Asn Ser Ser Ile Gln  Tyr Asn Ser 
    1115                 1120                 1125             


Ile Gln  Ile Thr Glu Lys Leu  Lys Glu Leu Phe Val  Asp Ile Pro 
    1130                 1135                 1140             


Phe Ser  Asn Gly Gln Asp Leu  Lys Pro Glu Ile Leu  Arg Lys Asn 
    1145                 1150                 1155             


Asp Ala  Val Phe Phe Lys Ser  Leu Leu Phe Tyr Ile  Lys Thr Thr 
    1160                 1165                 1170             


Leu Ser  Leu Arg Gln Asn Asn  Gly Lys Lys Gly Glu  Glu Glu Lys 
    1175                 1180                 1185             


Asp Phe  Ile Leu Ser Pro Val  Val Asp Ser Lys Gly  Arg Phe Phe 
    1190                 1195                 1200             


Asn Ser  Leu Glu Ala Ser Asp  Asp Glu Pro Lys Asp  Ala Asp Ala 
    1205                 1210                 1215             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Leu Met  Asn Leu Leu 
    1220                 1225                 1230             


Val Leu  Asn Glu Thr Lys Glu  Glu Asn Leu Ser Arg  Pro Lys Trp 
    1235                 1240                 1245             


Lys Ile  Lys Asn Lys Asp Trp  Leu Glu Phe Val Trp  Glu Arg Asn 
    1250                 1255                 1260             


Arg 
    


<210>  26
<211>  1373
<212>  PRT
<213>  Moraxella bovoculi

<400>  26

Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Phe Ile Asp Arg Thr Leu Glu His Ile His Ala Lys 
            20                  25                  30          


Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met His Gln Lys Val 
        35                  40                  45              


Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met Met 
    50                  55                  60                  


Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr Leu 
65                  70                  75                  80  


Lys Phe Arg Lys Asn Pro Lys Asp Asp Glu Leu Gln Lys Ala Gln Leu 
                85                  90                  95      


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ile Val Lys Pro Ile Gly 
            100                 105                 110         


Asn Gly Gly Lys Tyr Lys Ala Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
        115                 120                 125             


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
    130                 135                 140                 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
145                 150                 155                 160 


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
                165                 170                 175     


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
            180                 185                 190         


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
        195                 200                 205             


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
    210                 215                 220                 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
225                 230                 235                 240 


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Thr Leu Leu 
                245                 250                 255     


Gly Gly Ile Ser Gly Glu Ala Gly Ser Pro Lys Ile Gln Gly Ile Asn 
            260                 265                 270         


Glu Leu Ile Asn Ser His His Asn Gln His Cys His Lys Ser Glu Arg 
        275                 280                 285             


Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser Asp Gly Met 
    290                 295                 300                 


Ser Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser Glu Met Cys 
305                 310                 315                 320 


Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Ala Asp Val Phe Ala Lys 
                325                 330                 335     


Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys Asp Gly Ile 
            340                 345                 350         


Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln Ala Phe Gly 
        355                 360                 365             


Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr Val Asp Val 
    370                 375                 380                 


Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys Thr Asp Asn 
385                 390                 395                 400 


Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile Lys Gly Val 
                405                 410                 415     


His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His Tyr Thr Ala Arg 
            420                 425                 430         


His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln Tyr Phe Lys 
        435                 440                 445             


His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile His Asn Asn 
    450                 455                 460                 


His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro Ala Gly Glu 
465                 470                 475                 480 


Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu Met Thr Gln 
                485                 490                 495     


Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn Val Ala His 
            500                 505                 510         


Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn Gln Asp Gly 
        515                 520                 525             


Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu Ala Lys Ile 
    530                 535                 540                 


Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln Lys Pro Phe 
545                 550                 555                 560 


Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr Leu Leu Asn 
                565                 570                 575     


Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val Ile Leu Gln 
            580                 585                 590         


Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala His Lys Lys 
        595                 600                 605             


Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Ser Ile Tyr Gln Lys Met 
    610                 615                 620                 


Ile Tyr Lys Tyr Leu Glu Val Arg Lys Gln Phe Pro Lys Val Phe Phe 
625                 630                 635                 640 


Ser Lys Glu Ala Ile Ala Ile Asn Tyr His Pro Ser Lys Glu Leu Val 
                645                 650                 655     


Glu Ile Lys Asp Lys Gly Arg Gln Arg Ser Asp Asp Glu Arg Leu Lys 
            660                 665                 670         


Leu Tyr Arg Phe Ile Leu Glu Cys Leu Lys Ile His Pro Lys Tyr Asp 
        675                 680                 685             


Lys Lys Phe Glu Gly Ala Ile Gly Asp Ile Gln Leu Phe Lys Lys Asp 
    690                 695                 700                 


Lys Lys Gly Arg Glu Val Pro Ile Ser Glu Lys Asp Leu Phe Lys Asp 
705                 710                 715                 720 


Ile Asn Gly Ile Phe Ser Ser Lys Pro Lys Leu Glu Met Glu Asp Phe 
                725                 730                 735     


Phe Ile Gly Glu Phe Lys Arg Tyr Asn Pro Ser Gln Asp Leu Val Asp 
            740                 745                 750         


Gln Tyr Asn Ile Tyr Lys Lys Ile Asp Ser Asn Asp Asn Arg Lys Lys 
        755                 760                 765             


Glu Asn Phe Tyr Asn Asn His Pro Lys Phe Lys Lys Asp Leu Val Arg 
    770                 775                 780                 


Tyr Tyr Tyr Glu Ser Met Cys Lys His Glu Glu Trp Glu Glu Ser Phe 
785                 790                 795                 800 


Glu Phe Ser Lys Lys Leu Gln Asp Ile Gly Cys Tyr Val Asp Val Asn 
                805                 810                 815     


Glu Leu Phe Thr Glu Ile Glu Thr Arg Arg Leu Asn Tyr Lys Ile Ser 
            820                 825                 830         


Phe Cys Asn Ile Asn Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly 
        835                 840                 845             


Gln Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala 
    850                 855                 860                 


His Gly Lys Pro Asn Leu His Thr Leu Tyr Phe Lys Ala Leu Phe Ser 
865                 870                 875                 880 


Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln 
                885                 890                 895     


Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met Asn Glu Thr Thr Ile His 
            900                 905                 910         


Arg Ala Gly Glu Val Leu Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys 
        915                 920                 925             


Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Lys 
    930                 935                 940                 


Asp Phe Met Leu His Val Pro Ile Thr Met Asn Phe Gly Val Gln Gly 
945                 950                 955                 960 


Met Thr Ile Lys Glu Phe Asn Lys Lys Val Asn Gln Ser Ile Gln Gln 
                965                 970                 975     


Tyr Asp Glu Val Asn Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu 
            980                 985                 990         


Leu Tyr Leu Thr Val Ile Asn Ser  Lys Gly Glu Ile Leu  Glu Gln Cys 
        995                 1000                 1005             


Ser Leu  Asn Asp Ile Thr Thr  Ala Ser Ala Asn Gly  Thr Gln Met 
    1010                 1015                 1020             


Thr Thr  Pro Tyr His Lys Ile  Leu Asp Lys Arg Glu  Ile Glu Arg 
    1025                 1030                 1035             


Leu Asn  Ala Arg Val Gly Trp  Gly Glu Ile Glu Thr  Ile Lys Glu 
    1040                 1045                 1050             


Leu Lys  Ser Gly Tyr Leu Ser  His Val Val His Gln  Ile Ser Gln 
    1055                 1060                 1065             


Leu Met  Leu Lys Tyr Asn Ala  Ile Val Val Leu Glu  Asp Leu Asn 
    1070                 1075                 1080             


Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Lys  Gln Ile Tyr 
    1085                 1090                 1095             


Gln Asn  Phe Glu Asn Ala Leu  Ile Lys Lys Leu Asn  His Leu Val 
    1100                 1105                 1110             


Leu Lys  Asp Lys Ala Asp Asp  Glu Ile Gly Ser Tyr  Lys Asn Ala 
    1115                 1120                 1125             


Leu Gln  Leu Thr Asn Asn Phe  Thr Asp Leu Lys Ser  Ile Gly Lys 
    1130                 1135                 1140             


Gln Thr  Gly Phe Leu Phe Tyr  Val Pro Ala Trp Asn  Thr Ser Lys 
    1145                 1150                 1155             


Ile Asp  Pro Glu Thr Gly Phe  Val Asp Leu Leu Lys  Pro Arg Tyr 
    1160                 1165                 1170             


Glu Asn  Ile Gln Ala Ser Gln  Ala Phe Phe Gly Lys  Phe Asp Lys 
    1175                 1180                 1185             


Ile Cys  Tyr Asn Ala Asp Lys  Asp Tyr Phe Glu Phe  His Ile Asp 
    1190                 1195                 1200             


Tyr Ala  Lys Phe Thr Asp Lys  Ala Lys Asn Ser Arg  Gln Ile Trp 
    1205                 1210                 1215             


Thr Ile  Cys Ser His Gly Asp  Lys Arg Tyr Val Tyr  Asp Lys Thr 
    1220                 1225                 1230             


Ala Asn  Gln Asn Lys Gly Ala  Ala Lys Gly Ile Asn  Val Asn Asp 
    1235                 1240                 1245             


Ile Leu  Lys Ser Leu Phe Ala  Arg His His Ile Asn  Glu Lys Gln 
    1250                 1255                 1260             


Pro Asn  Leu Val Met Asp Ile  Cys Gln Asn Asn Asp  Lys Glu Phe 
    1265                 1270                 1275             


His Lys  Ser Leu Met Tyr Leu  Leu Lys Thr Leu Leu  Ala Leu Arg 
    1280                 1285                 1290             


Tyr Ser  Asn Ala Ser Ser Asp  Glu Asp Phe Ile Leu  Ser Pro Val 
    1295                 1300                 1305             


Ala Asn  Asp Glu Gly Val Phe  Phe Asn Ser Ala Leu  Ala Asp Asp 
    1310                 1315                 1320             


Thr Gln  Pro Gln Asn Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala 
    1325                 1330                 1335             


Leu Lys  Gly Leu Trp Leu Leu  Asn Glu Leu Lys Asn  Ser Asp Asp 
    1340                 1345                 1350             


Leu Asn  Lys Val Lys Leu Ala  Ile Asp Asn Gln Thr  Trp Leu Asn 
    1355                 1360                 1365             


Phe Ala  Gln Asn Arg 
    1370             


<210>  27
<211>  1352
<212>  PRT
<213>  Unknown

<220>
<223>  Parcubacteria bacterium

<400>  27

Met Glu Asn Ile Phe Asp Gln Phe Ile Gly Lys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Glu Asp Phe Leu 
            20                  25                  30          


Lys Ile Asn Lys Val Phe Glu Lys Asp Gln Thr Ile Asp Asp Ser Tyr 
        35                  40                  45              


Asn Gln Ala Lys Phe Tyr Phe Asp Ser Leu His Gln Lys Phe Ile Asp 
    50                  55                  60                  


Ala Ala Leu Ala Ser Asp Lys Thr Ser Glu Leu Ser Phe Gln Asn Phe 
65                  70                  75                  80  


Ala Asp Val Leu Glu Lys Gln Asn Lys Ile Ile Leu Asp Lys Lys Arg 
                85                  90                  95      


Glu Met Gly Ala Leu Arg Lys Arg Asp Lys Asn Ala Val Gly Ile Asp 
            100                 105                 110         


Arg Leu Gln Lys Glu Ile Asn Asp Ala Glu Asp Ile Ile Gln Lys Glu 
        115                 120                 125             


Lys Glu Lys Ile Tyr Lys Asp Val Arg Thr Leu Phe Asp Asn Glu Ala 
    130                 135                 140                 


Glu Ser Trp Lys Thr Tyr Tyr Gln Glu Arg Glu Val Asp Gly Lys Lys 
145                 150                 155                 160 


Ile Thr Glu Ser Lys Ala Asp Leu Lys Gln Lys Gly Ala Asp Phe Leu 
                165                 170                 175     


Thr Ala Ala Gly Ile Leu Lys Val Leu Lys Tyr Glu Phe Pro Glu Glu 
            180                 185                 190         


Lys Glu Lys Glu Phe Gln Ala Lys Asn Gln Pro Ser Leu Phe Val Glu 
        195                 200                 205             


Glu Lys Glu Asn Pro Gly Gln Lys Arg Tyr Ile Phe Asp Ser Phe Asp 
    210                 215                 220                 


Lys Phe Ala Gly Tyr Leu Thr Lys Phe Gln Gln Thr Lys Lys Asn Leu 
225                 230                 235                 240 


Tyr Ala Ala Asp Gly Thr Ser Thr Ala Val Ala Thr Arg Ile Ala Asp 
                245                 250                 255     


Asn Phe Ile Ile Phe His Gln Asn Thr Lys Val Phe Arg Asp Lys Tyr 
            260                 265                 270         


Lys Asn Asn His Thr Asp Leu Gly Phe Asp Glu Glu Asn Ile Phe Glu 
        275                 280                 285             


Ile Glu Arg Tyr Lys Asn Cys Leu Leu Gln Arg Glu Ile Glu His Ile 
    290                 295                 300                 


Lys Asn Glu Asn Ser Tyr Asn Lys Ile Ile Gly Arg Ile Asn Lys Lys 
305                 310                 315                 320 


Ile Lys Glu Tyr Arg Asp Gln Lys Ala Lys Asp Thr Lys Leu Thr Lys 
                325                 330                 335     


Ser Asp Phe Pro Phe Phe Lys Asn Leu Asp Lys Gln Ile Leu Gly Glu 
            340                 345                 350         


Val Glu Lys Glu Lys Gln Leu Ile Glu Lys Thr Arg Glu Lys Thr Glu 
        355                 360                 365             


Glu Asp Val Leu Ile Glu Arg Phe Lys Glu Phe Ile Glu Asn Asn Glu 
    370                 375                 380                 


Glu Arg Phe Thr Ala Ala Lys Lys Leu Met Asn Ala Phe Cys Asn Gly 
385                 390                 395                 400 


Glu Phe Glu Ser Glu Tyr Glu Gly Ile Tyr Leu Lys Asn Lys Ala Ile 
                405                 410                 415     


Asn Thr Ile Ser Arg Arg Trp Phe Val Ser Asp Arg Asp Phe Glu Leu 
            420                 425                 430         


Lys Leu Pro Gln Gln Lys Ser Lys Asn Lys Ser Glu Lys Asn Glu Pro 
        435                 440                 445             


Lys Val Lys Lys Phe Ile Ser Ile Ala Glu Ile Lys Asn Ala Val Glu 
    450                 455                 460                 


Glu Leu Asp Gly Asp Ile Phe Lys Ala Val Phe Tyr Asp Lys Lys Ile 
465                 470                 475                 480 


Ile Ala Gln Gly Gly Ser Lys Leu Glu Gln Phe Leu Val Ile Trp Lys 
                485                 490                 495     


Tyr Glu Phe Glu Tyr Leu Phe Arg Asp Ile Glu Arg Glu Asn Gly Glu 
            500                 505                 510         


Lys Leu Leu Gly Tyr Asp Ser Cys Leu Lys Ile Ala Lys Gln Leu Gly 
        515                 520                 525             


Ile Phe Pro Gln Glu Lys Glu Ala Arg Glu Lys Ala Thr Ala Val Ile 
    530                 535                 540                 


Lys Asn Tyr Ala Asp Ala Gly Leu Gly Ile Phe Gln Met Met Lys Tyr 
545                 550                 555                 560 


Phe Ser Leu Asp Asp Lys Asp Arg Lys Asn Thr Pro Gly Gln Leu Ser 
                565                 570                 575     


Thr Asn Phe Tyr Ala Glu Tyr Asp Gly Tyr Tyr Lys Asp Phe Glu Phe 
            580                 585                 590         


Ile Lys Tyr Tyr Asn Glu Phe Arg Asn Phe Ile Thr Lys Lys Pro Phe 
        595                 600                 605             


Asp Glu Asp Lys Ile Lys Leu Asn Phe Glu Asn Gly Ala Leu Leu Lys 
    610                 615                 620                 


Gly Trp Asp Glu Asn Lys Glu Tyr Asp Phe Met Gly Val Ile Leu Lys 
625                 630                 635                 640 


Lys Glu Gly Arg Leu Tyr Leu Gly Ile Met His Lys Asn His Arg Lys 
                645                 650                 655     


Leu Phe Gln Ser Met Gly Asn Ala Lys Gly Asp Asn Ala Asn Arg Tyr 
            660                 665                 670         


Gln Lys Met Ile Tyr Lys Gln Ile Ala Asp Ala Ser Lys Asp Val Pro 
        675                 680                 685             


Arg Leu Leu Leu Thr Ser Lys Lys Ala Met Glu Lys Phe Lys Pro Ser 
    690                 695                 700                 


Gln Glu Ile Leu Arg Ile Lys Lys Glu Lys Thr Phe Lys Arg Glu Ser 
705                 710                 715                 720 


Lys Asn Phe Ser Leu Arg Asp Leu His Ala Leu Ile Glu Tyr Tyr Arg 
                725                 730                 735     


Asn Cys Ile Pro Gln Tyr Ser Asn Trp Ser Phe Tyr Asp Phe Gln Phe 
            740                 745                 750         


Gln Asp Thr Gly Lys Tyr Gln Asn Ile Lys Glu Phe Thr Asp Asp Val 
        755                 760                 765             


Gln Lys Tyr Gly Tyr Lys Ile Ser Phe Arg Asp Ile Asp Asp Glu Tyr 
    770                 775                 780                 


Ile Asn Gln Ala Leu Asn Glu Gly Lys Met Tyr Leu Phe Glu Val Val 
785                 790                 795                 800 


Asn Lys Asp Ile Tyr Asn Thr Lys Asn Gly Ser Lys Asn Leu His Thr 
                805                 810                 815     


Leu Tyr Phe Glu His Ile Leu Ser Ala Glu Asn Leu Asn Asp Pro Val 
            820                 825                 830         


Phe Lys Leu Ser Gly Met Ala Glu Ile Phe Gln Arg Gln Pro Ser Val 
        835                 840                 845             


Asn Glu Arg Glu Lys Ile Thr Thr Gln Lys Asn Gln Cys Ile Leu Asp 
    850                 855                 860                 


Lys Gly Asp Arg Ala Tyr Lys Tyr Arg Arg Tyr Thr Glu Lys Lys Ile 
865                 870                 875                 880 


Met Phe His Met Ser Leu Val Leu Asn Thr Gly Lys Gly Glu Ile Lys 
                885                 890                 895     


Gln Val Gln Phe Asn Lys Ile Ile Asn Gln Arg Ile Ser Ser Ser Asp 
            900                 905                 910         


Asn Glu Met Arg Val Asn Val Ile Gly Ile Asp Arg Gly Glu Lys Asn 
        915                 920                 925             


Leu Leu Tyr Tyr Ser Val Val Lys Gln Asn Gly Glu Ile Ile Glu Gln 
    930                 935                 940                 


Ala Ser Leu Asn Glu Ile Asn Gly Val Asn Tyr Arg Asp Lys Leu Ile 
945                 950                 955                 960 


Glu Arg Glu Lys Glu Arg Leu Lys Asn Arg Gln Ser Trp Lys Pro Val 
                965                 970                 975     


Val Lys Ile Lys Asp Leu Lys Lys Gly Tyr Ile Ser His Val Ile His 
            980                 985                 990         


Lys Ile Cys Gln Leu Ile Glu Lys  Tyr Ser Ala Ile Val  Val Leu Glu 
        995                 1000                 1005             


Asp Leu  Asn Met Arg Phe Lys  Gln Ile Arg Gly Gly  Ile Glu Arg 
    1010                 1015                 1020             


Ser Val  Tyr Gln Gln Phe Glu  Lys Ala Leu Ile Asp  Lys Leu Gly 
    1025                 1030                 1035             


Tyr Leu  Val Phe Lys Asp Asn  Arg Asp Leu Arg Ala  Pro Gly Gly 
    1040                 1045                 1050             


Val Leu  Asn Gly Tyr Gln Leu  Ser Ala Pro Phe Val  Ser Phe Glu 
    1055                 1060                 1065             


Lys Met  Arg Lys Gln Thr Gly  Ile Leu Phe Tyr Thr  Gln Ala Glu 
    1070                 1075                 1080             


Tyr Thr  Ser Lys Thr Asp Pro  Ile Thr Gly Phe Arg  Lys Asn Val 
    1085                 1090                 1095             


Tyr Ile  Ser Asn Ser Ala Ser  Leu Asp Lys Ile Lys  Glu Ala Val 
    1100                 1105                 1110             


Lys Lys  Phe Asp Ala Ile Gly  Trp Asp Gly Lys Glu  Gln Ser Tyr 
    1115                 1120                 1125             


Phe Phe  Lys Tyr Asn Pro Tyr  Asn Leu Ala Asp Glu  Lys Tyr Lys 
    1130                 1135                 1140             


Asn Ser  Thr Val Ser Lys Glu  Trp Ala Ile Phe Ala  Ser Ala Pro 
    1145                 1150                 1155             


Arg Ile  Arg Arg Gln Lys Gly  Glu Asp Gly Tyr Trp  Lys Tyr Asp 
    1160                 1165                 1170             


Arg Val  Lys Val Asn Glu Glu  Phe Glu Lys Leu Leu  Lys Val Trp 
    1175                 1180                 1185             


Asn Phe  Val Asn Pro Lys Ala  Thr Asp Ile Lys Gln  Glu Ile Ile 
    1190                 1195                 1200             


Lys Lys  Ile Lys Ala Gly Asp  Leu Gln Gly Glu Lys  Glu Leu Asp 
    1205                 1210                 1215             


Gly Arg  Leu Arg Asn Phe Trp  His Ser Phe Ile Tyr  Leu Phe Asn 
    1220                 1225                 1230             


Leu Val  Leu Glu Leu Arg Asn  Ser Phe Ser Leu Gln  Ile Lys Ile 
    1235                 1240                 1245             


Lys Ala  Gly Glu Val Ile Ala  Val Asp Glu Gly Val  Asp Phe Ile 
    1250                 1255                 1260             


Ala Ser  Pro Val Lys Pro Phe  Phe Thr Thr Pro Asn  Pro Tyr Ile 
    1265                 1270                 1275             


Pro Ser  Asn Leu Cys Trp Leu  Ala Val Glu Asn Ala  Asp Ala Asn 
    1280                 1285                 1290             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Val Met Ile  Leu Lys Lys 
    1295                 1300                 1305             


Ile Arg  Glu His Ala Lys Lys  Asp Pro Glu Phe Lys  Lys Leu Pro 
    1310                 1315                 1320             


Asn Leu  Phe Ile Ser Asn Ala  Glu Trp Asp Glu Ala  Ala Arg Asp 
    1325                 1330                 1335             


Trp Gly  Lys Tyr Ala Gly Thr  Thr Ala Leu Asn Leu  Asp His 
    1340                 1345                 1350         


<210>  28
<211>  1260
<212>  PRT
<213>  Porphyromonas crevioricanis

<400>  28

Met Asp Ser Leu Lys Asp Phe Thr Asn Leu Tyr Pro Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu Asn Ile Glu 
            20                  25                  30          


Lys Ala Gly Ile Leu Lys Glu Asp Glu His Arg Ala Glu Ser Tyr Arg 
        35                  40                  45              


Arg Val Lys Lys Ile Ile Asp Thr Tyr His Lys Val Phe Ile Asp Ser 
    50                  55                  60                  


Ser Leu Glu Asn Met Ala Lys Met Gly Ile Glu Asn Glu Ile Lys Ala 
65                  70                  75                  80  


Met Leu Gln Ser Phe Cys Glu Leu Tyr Lys Lys Asp His Arg Thr Glu 
                85                  90                  95      


Gly Glu Asp Lys Ala Leu Asp Lys Ile Arg Ala Val Leu Arg Gly Leu 
            100                 105                 110         


Ile Val Gly Ala Phe Thr Gly Val Cys Gly Arg Arg Glu Asn Thr Val 
        115                 120                 125             


Gln Asn Glu Lys Tyr Glu Ser Leu Phe Lys Glu Lys Leu Ile Lys Glu 
    130                 135                 140                 


Ile Leu Pro Asp Phe Val Leu Ser Thr Glu Ala Glu Ser Leu Pro Phe 
145                 150                 155                 160 


Ser Val Glu Glu Ala Thr Arg Ser Leu Lys Glu Phe Asp Ser Phe Thr 
                165                 170                 175     


Ser Tyr Phe Ala Gly Phe Tyr Glu Asn Arg Lys Asn Ile Tyr Ser Thr 
            180                 185                 190         


Lys Pro Gln Ser Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu 
        195                 200                 205             


Pro Lys Phe Ile Asp Asn Ile Leu Val Phe Gln Lys Ile Lys Glu Pro 
    210                 215                 220                 


Ile Ala Lys Glu Leu Glu His Ile Arg Ala Asp Phe Ser Ala Gly Gly 
225                 230                 235                 240 


Tyr Ile Lys Lys Asp Glu Arg Leu Glu Asp Ile Phe Ser Leu Asn Tyr 
                245                 250                 255     


Tyr Ile His Val Leu Ser Gln Ala Gly Ile Glu Lys Tyr Asn Ala Leu 
            260                 265                 270         


Ile Gly Lys Ile Val Thr Glu Gly Asp Gly Glu Met Lys Gly Leu Asn 
        275                 280                 285             


Glu His Ile Asn Leu Tyr Asn Gln Gln Arg Gly Arg Glu Asp Arg Leu 
    290                 295                 300                 


Pro Leu Phe Arg Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Gln 
305                 310                 315                 320 


Leu Ser Tyr Leu Pro Glu Ser Phe Glu Lys Asp Glu Glu Leu Leu Arg 
                325                 330                 335     


Ala Leu Lys Glu Phe Tyr Asp His Ile Ala Glu Asp Ile Leu Gly Arg 
            340                 345                 350         


Thr Gln Gln Leu Met Thr Ser Ile Ser Glu Tyr Asp Leu Ser Arg Ile 
        355                 360                 365             


Tyr Val Arg Asn Asp Ser Gln Leu Thr Asp Ile Ser Lys Lys Met Leu 
    370                 375                 380                 


Gly Asp Trp Asn Ala Ile Tyr Met Ala Arg Glu Arg Ala Tyr Asp His 
385                 390                 395                 400 


Glu Gln Ala Pro Lys Arg Ile Thr Ala Lys Tyr Glu Arg Asp Arg Ile 
                405                 410                 415     


Lys Ala Leu Lys Gly Glu Glu Ser Ile Ser Leu Ala Asn Leu Asn Ser 
            420                 425                 430         


Cys Ile Ala Phe Leu Asp Asn Val Arg Asp Cys Arg Val Asp Thr Tyr 
        435                 440                 445             


Leu Ser Thr Leu Gly Gln Lys Glu Gly Pro His Gly Leu Ser Asn Leu 
    450                 455                 460                 


Val Glu Asn Val Phe Ala Ser Tyr His Glu Ala Glu Gln Leu Leu Ser 
465                 470                 475                 480 


Phe Pro Tyr Pro Glu Glu Asn Asn Leu Ile Gln Asp Lys Asp Asn Val 
                485                 490                 495     


Val Leu Ile Lys Asn Leu Leu Asp Asn Ile Ser Asp Leu Gln Arg Phe 
            500                 505                 510         


Leu Lys Pro Leu Trp Gly Met Gly Asp Glu Pro Asp Lys Asp Glu Arg 
        515                 520                 525             


Phe Tyr Gly Glu Tyr Asn Tyr Ile Arg Gly Ala Leu Asp Gln Val Ile 
    530                 535                 540                 


Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Arg Lys Pro Tyr Ser 
545                 550                 555                 560 


Thr Arg Lys Val Lys Leu Asn Phe Gly Asn Ser Gln Leu Leu Ser Gly 
                565                 570                 575     


Trp Asp Arg Asn Lys Glu Lys Asp Asn Ser Cys Val Ile Leu Arg Lys 
            580                 585                 590         


Gly Gln Asn Phe Tyr Leu Ala Ile Met Asn Asn Arg His Lys Arg Ser 
        595                 600                 605             


Phe Glu Asn Lys Met Leu Pro Glu Tyr Lys Glu Gly Glu Pro Tyr Phe 
    610                 615                 620                 


Glu Lys Met Asp Tyr Lys Phe Leu Pro Asp Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Leu Ser Lys Lys Gly Ile Glu Ile Tyr Lys Pro Ser Pro 
                645                 650                 655     


Lys Leu Leu Glu Gln Tyr Gly His Gly Thr His Lys Lys Gly Asp Thr 
            660                 665                 670         


Phe Ser Met Asp Asp Leu His Glu Leu Ile Asp Phe Phe Lys His Ser 
        675                 680                 685             


Ile Glu Ala His Glu Asp Trp Lys Gln Phe Gly Phe Lys Phe Ser Asp 
    690                 695                 700                 


Thr Ala Thr Tyr Glu Asn Val Ser Ser Phe Tyr Arg Glu Val Glu Asp 
705                 710                 715                 720 


Gln Gly Tyr Lys Leu Ser Phe Arg Lys Val Ser Glu Ser Tyr Val Tyr 
                725                 730                 735     


Ser Leu Ile Asp Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ser Pro Cys Ser Lys Gly Thr Pro Asn Leu His Thr Leu Tyr 
        755                 760                 765             


Trp Arg Met Leu Phe Asp Glu Arg Asn Leu Ala Asp Val Ile Tyr Lys 
    770                 775                 780                 


Leu Asp Gly Lys Ala Glu Ile Phe Phe Arg Glu Lys Ser Leu Lys Asn 
785                 790                 795                 800 


Asp His Pro Thr His Pro Ala Gly Lys Pro Ile Lys Lys Lys Ser Arg 
                805                 810                 815     


Gln Lys Lys Gly Glu Glu Ser Leu Phe Glu Tyr Asp Leu Val Lys Asp 
            820                 825                 830         


Arg Arg Tyr Thr Met Asp Lys Phe Gln Phe His Val Pro Ile Thr Met 
        835                 840                 845             


Asn Phe Lys Cys Ser Ala Gly Ser Lys Val Asn Asp Met Val Asn Ala 
    850                 855                 860                 


His Ile Arg Glu Ala Lys Asp Met His Val Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg Asn Leu Leu Tyr Ile Cys Val Ile Asp Ser Arg Gly Thr Ile 
                885                 890                 895     


Leu Asp Gln Ile Ser Leu Asn Thr Ile Asn Asp Ile Asp Tyr His Asp 
            900                 905                 910         


Leu Leu Glu Ser Arg Asp Lys Asp Arg Gln Gln Glu His Arg Asn Trp 
        915                 920                 925             


Gln Thr Ile Glu Gly Ile Lys Glu Leu Lys Gln Gly Tyr Leu Ser Gln 
    930                 935                 940                 


Ala Val His Arg Ile Ala Glu Leu Met Val Ala Tyr Lys Ala Val Val 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Met Gly Phe Lys Arg Gly Arg Gln Lys Val 
                965                 970                 975     


Glu Ser Ser Val Tyr Gln Gln Phe Glu Lys Gln Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Leu Val Asp Lys Lys Lys  Arg Pro Glu Asp Ile  Gly Gly Leu 
        995                 1000                 1005             


Leu Arg  Ala Tyr Gln Phe Thr  Ala Pro Phe Lys Ser  Phe Lys Glu 
    1010                 1015                 1020             


Met Gly  Lys Gln Asn Gly Phe  Leu Phe Tyr Ile Pro  Ala Trp Asn 
    1025                 1030                 1035             


Thr Ser  Asn Ile Asp Pro Thr  Thr Gly Phe Val Asn  Leu Phe His 
    1040                 1045                 1050             


Val Gln  Tyr Glu Asn Val Asp  Lys Ala Lys Ser Phe  Phe Gln Lys 
    1055                 1060                 1065             


Phe Asp  Ser Ile Ser Tyr Asn  Pro Lys Lys Asp Trp  Phe Glu Phe 
    1070                 1075                 1080             


Ala Phe  Asp Tyr Lys Asn Phe  Thr Lys Lys Ala Glu  Gly Ser Arg 
    1085                 1090                 1095             


Ser Met  Trp Ile Leu Cys Thr  His Gly Ser Arg Ile  Lys Asn Phe 
    1100                 1105                 1110             


Arg Asn  Ser Gln Lys Asn Gly  Gln Trp Asp Ser Glu  Glu Phe Ala 
    1115                 1120                 1125             


Leu Thr  Glu Ala Phe Lys Ser  Leu Phe Val Arg Tyr  Glu Ile Asp 
    1130                 1135                 1140             


Tyr Thr  Ala Asp Leu Lys Thr  Ala Ile Val Asp Glu  Lys Gln Lys 
    1145                 1150                 1155             


Asp Phe  Phe Val Asp Leu Leu  Lys Leu Phe Lys Leu  Thr Val Gln 
    1160                 1165                 1170             


Met Arg  Asn Ser Trp Lys Glu  Lys Asp Leu Asp Tyr  Leu Ile Ser 
    1175                 1180                 1185             


Pro Val  Ala Gly Ala Asp Gly  Arg Phe Phe Asp Thr  Arg Glu Gly 
    1190                 1195                 1200             


Asn Lys  Ser Leu Pro Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1205                 1210                 1215             


Ile Ala  Leu Lys Gly Leu Trp  Ala Leu Arg Gln Ile  Arg Gln Thr 
    1220                 1225                 1230             


Ser Glu  Gly Gly Lys Leu Lys  Leu Ala Ile Ser Asn  Lys Glu Trp 
    1235                 1240                 1245             


Leu Gln  Phe Val Gln Glu Arg  Ser Tyr Glu Lys Asp  
    1250                 1255                 1260 


<210>  29
<211>  1324
<212>  PRT
<213>  Prevotella disiens

<400>  29

Met Glu Asn Tyr Gln Glu Phe Thr Asn Leu Phe Gln Leu Asn Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Cys Glu Leu Leu Glu 
            20                  25                  30          


Glu Gly Lys Ile Phe Ala Ser Gly Ser Phe Leu Glu Lys Asp Lys Val 
        35                  40                  45              


Arg Ala Asp Asn Val Ser Tyr Val Lys Lys Glu Ile Asp Lys Lys His 
    50                  55                  60                  


Lys Ile Phe Ile Glu Glu Thr Leu Ser Ser Phe Ser Ile Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Lys Gln Tyr Phe Asp Cys Tyr Asn Glu Leu Lys Ala Phe Lys 
                85                  90                  95      


Lys Asp Cys Lys Ser Asp Glu Glu Glu Val Lys Lys Thr Ala Leu Arg 
            100                 105                 110         


Asn Lys Cys Thr Ser Ile Gln Arg Ala Met Arg Glu Ala Ile Ser Gln 
        115                 120                 125             


Ala Phe Leu Lys Ser Pro Gln Lys Lys Leu Leu Ala Ile Lys Asn Leu 
    130                 135                 140                 


Ile Glu Asn Val Phe Lys Ala Asp Glu Asn Val Gln His Phe Ser Glu 
145                 150                 155                 160 


Phe Thr Ser Tyr Phe Ser Gly Phe Glu Thr Asn Arg Glu Asn Phe Tyr 
                165                 170                 175     


Ser Asp Glu Glu Lys Ser Thr Ser Ile Ala Tyr Arg Leu Val His Asp 
            180                 185                 190         


Asn Leu Pro Ile Phe Ile Lys Asn Ile Tyr Ile Phe Glu Lys Leu Lys 
        195                 200                 205             


Glu Gln Phe Asp Ala Lys Thr Leu Ser Glu Ile Phe Glu Asn Tyr Lys 
    210                 215                 220                 


Leu Tyr Val Ala Gly Ser Ser Leu Asp Glu Val Phe Ser Leu Glu Tyr 
225                 230                 235                 240 


Phe Asn Asn Thr Leu Thr Gln Lys Gly Ile Asp Asn Tyr Asn Ala Val 
                245                 250                 255     


Ile Gly Lys Ile Val Lys Glu Asp Lys Gln Glu Ile Gln Gly Leu Asn 
            260                 265                 270         


Glu His Ile Asn Leu Tyr Asn Gln Lys His Lys Asp Arg Arg Leu Pro 
        275                 280                 285             


Phe Phe Ile Ser Leu Lys Lys Gln Ile Leu Ser Asp Arg Glu Ala Leu 
    290                 295                 300                 


Ser Trp Leu Pro Asp Met Phe Lys Asn Asp Ser Glu Val Ile Asp Ala 
305                 310                 315                 320 


Leu Lys Gly Phe Tyr Ile Glu Asp Gly Phe Glu Asn Asn Val Leu Thr 
                325                 330                 335     


Pro Leu Ala Thr Leu Leu Ser Ser Leu Asp Lys Tyr Asn Leu Asn Gly 
            340                 345                 350         


Ile Phe Ile Arg Asn Asn Glu Ala Leu Ser Ser Leu Ser Gln Asn Val 
        355                 360                 365             


Tyr Arg Asn Phe Ser Ile Asp Glu Ala Ile Asp Ala Gln Asn Ala Glu 
    370                 375                 380                 


Leu Gln Thr Phe Asn Asn Tyr Glu Leu Ile Ala Asn Ala Leu Arg Ala 
385                 390                 395                 400 


Lys Ile Lys Lys Glu Thr Lys Gln Gly Arg Lys Ser Phe Glu Lys Tyr 
                405                 410                 415     


Glu Glu Tyr Ile Asp Lys Lys Val Lys Ala Ile Asp Ser Leu Ser Ile 
            420                 425                 430         


Gln Glu Ile Asn Glu Leu Val Glu Asn Tyr Val Ser Glu Phe Asn Ser 
        435                 440                 445             


Asn Ser Gly Asn Met Pro Arg Lys Val Glu Asp Tyr Phe Ser Leu Met 
    450                 455                 460                 


Arg Lys Gly Asp Phe Gly Ser Asn Asp Leu Ile Glu Asn Ile Lys Thr 
465                 470                 475                 480 


Lys Leu Ser Ala Ala Glu Lys Leu Leu Gly Thr Lys Tyr Gln Glu Thr 
                485                 490                 495     


Ala Lys Asp Ile Phe Lys Lys Asp Glu Asn Ser Lys Leu Ile Lys Glu 
            500                 505                 510         


Leu Leu Asp Ala Thr Lys Gln Phe Gln His Phe Ile Lys Pro Leu Leu 
        515                 520                 525             


Gly Thr Gly Glu Glu Ala Asp Arg Asp Leu Val Phe Tyr Gly Asp Phe 
    530                 535                 540                 


Leu Pro Leu Tyr Glu Lys Phe Glu Glu Leu Thr Leu Leu Tyr Asn Lys 
545                 550                 555                 560 


Val Arg Asn Arg Leu Thr Gln Lys Pro Tyr Ser Lys Asp Lys Ile Arg 
                565                 570                 575     


Leu Cys Phe Asn Lys Pro Lys Leu Met Thr Gly Trp Val Asp Ser Lys 
            580                 585                 590         


Thr Glu Lys Ser Asp Asn Gly Thr Gln Tyr Gly Gly Tyr Leu Phe Arg 
        595                 600                 605             


Lys Lys Asn Glu Ile Gly Glu Tyr Asp Tyr Phe Leu Gly Ile Ser Ser 
    610                 615                 620                 


Lys Ala Gln Leu Phe Arg Lys Asn Glu Ala Val Ile Gly Asp Tyr Glu 
625                 630                 635                 640 


Arg Leu Asp Tyr Tyr Gln Pro Lys Ala Asn Thr Ile Tyr Gly Ser Ala 
                645                 650                 655     


Tyr Glu Gly Glu Asn Ser Tyr Lys Glu Asp Lys Lys Arg Leu Asn Lys 
            660                 665                 670         


Val Ile Ile Ala Tyr Ile Glu Gln Ile Lys Gln Thr Asn Ile Lys Lys 
        675                 680                 685             


Ser Ile Ile Glu Ser Ile Ser Lys Tyr Pro Asn Ile Ser Asp Asp Asp 
    690                 695                 700                 


Lys Val Thr Pro Ser Ser Leu Leu Glu Lys Ile Lys Lys Val Ser Ile 
705                 710                 715                 720 


Asp Ser Tyr Asn Gly Ile Leu Ser Phe Lys Ser Phe Gln Ser Val Asn 
                725                 730                 735     


Lys Glu Val Ile Asp Asn Leu Leu Lys Thr Ile Ser Pro Leu Lys Asn 
            740                 745                 750         


Lys Ala Glu Phe Leu Asp Leu Ile Asn Lys Asp Tyr Gln Ile Phe Thr 
        755                 760                 765             


Glu Val Gln Ala Val Ile Asp Glu Ile Cys Lys Gln Lys Thr Phe Ile 
    770                 775                 780                 


Tyr Phe Pro Ile Ser Asn Val Glu Leu Glu Lys Glu Met Gly Asp Lys 
785                 790                 795                 800 


Asp Lys Pro Leu Cys Leu Phe Gln Ile Ser Asn Lys Asp Leu Ser Phe 
                805                 810                 815     


Ala Lys Thr Phe Ser Ala Asn Leu Arg Lys Lys Arg Gly Ala Glu Asn 
            820                 825                 830         


Leu His Thr Met Leu Phe Lys Ala Leu Met Glu Gly Asn Gln Asp Asn 
        835                 840                 845             


Leu Asp Leu Gly Ser Gly Ala Ile Phe Tyr Arg Ala Lys Ser Leu Asp 
    850                 855                 860                 


Gly Asn Lys Pro Thr His Pro Ala Asn Glu Ala Ile Lys Cys Arg Asn 
865                 870                 875                 880 


Val Ala Asn Lys Asp Lys Val Ser Leu Phe Thr Tyr Asp Ile Tyr Lys 
                885                 890                 895     


Asn Arg Arg Tyr Met Glu Asn Lys Phe Leu Phe His Leu Ser Ile Val 
            900                 905                 910         


Gln Asn Tyr Lys Ala Ala Asn Asp Ser Ala Gln Leu Asn Ser Ser Ala 
        915                 920                 925             


Thr Glu Tyr Ile Arg Lys Ala Asp Asp Leu His Ile Ile Gly Ile Asp 
    930                 935                 940                 


Arg Gly Glu Arg Asn Leu Leu Tyr Tyr Ser Val Ile Asp Met Lys Gly 
945                 950                 955                 960 


Asn Ile Val Glu Gln Asp Ser Leu Asn Ile Ile Arg Asn Asn Asp Leu 
                965                 970                 975     


Glu Thr Asp Tyr His Asp Leu Leu Asp Lys Arg Glu Lys Glu Arg Lys 
            980                 985                 990         


Ala Asn Arg Gln Asn Trp Glu Ala  Val Glu Gly Ile Lys  Asp Leu Lys 
        995                 1000                 1005             


Lys Gly  Tyr Leu Ser Gln Ala  Val His Gln Ile Ala  Gln Leu Met 
    1010                 1015                 1020             


Leu Lys  Tyr Asn Ala Ile Ile  Ala Leu Glu Asp Leu  Gly Gln Met 
    1025                 1030                 1035             


Phe Val  Thr Arg Gly Gln Lys  Ile Glu Lys Ala Val  Tyr Gln Gln 
    1040                 1045                 1050             


Phe Glu  Lys Ser Leu Val Asp  Lys Leu Ser Tyr Leu  Val Asp Lys 
    1055                 1060                 1065             


Lys Arg  Pro Tyr Asn Glu Leu  Gly Gly Ile Leu Lys  Ala Tyr Gln 
    1070                 1075                 1080             


Leu Ala  Ser Ser Ile Thr Lys  Asn Asn Ser Asp Lys  Gln Asn Gly 
    1085                 1090                 1095             


Phe Leu  Phe Tyr Val Pro Ala  Trp Asn Thr Ser Lys  Ile Asp Pro 
    1100                 1105                 1110             


Val Thr  Gly Phe Thr Asp Leu  Leu Arg Pro Lys Ala  Met Thr Ile 
    1115                 1120                 1125             


Lys Glu  Ala Gln Asp Phe Phe  Gly Ala Phe Asp Asn  Ile Ser Tyr 
    1130                 1135                 1140             


Asn Asp  Lys Gly Tyr Phe Glu  Phe Glu Thr Asn Tyr  Asp Lys Phe 
    1145                 1150                 1155             


Lys Ile  Arg Met Lys Ser Ala  Gln Thr Arg Trp Thr  Ile Cys Thr 
    1160                 1165                 1170             


Phe Gly  Asn Arg Ile Lys Arg  Lys Lys Asp Lys Asn  Tyr Trp Asn 
    1175                 1180                 1185             


Tyr Glu  Glu Val Glu Leu Thr  Glu Glu Phe Lys Lys  Leu Phe Lys 
    1190                 1195                 1200             


Asp Ser  Asn Ile Asp Tyr Glu  Asn Cys Asn Leu Lys  Glu Glu Ile 
    1205                 1210                 1215             


Gln Asn  Lys Asp Asn Arg Lys  Phe Phe Asp Asp Leu  Ile Lys Leu 
    1220                 1225                 1230             


Leu Gln  Leu Thr Leu Gln Met  Arg Asn Ser Asp Asp  Lys Gly Asn 
    1235                 1240                 1245             


Asp Tyr  Ile Ile Ser Pro Val  Ala Asn Ala Glu Gly  Gln Phe Phe 
    1250                 1255                 1260             


Asp Ser  Arg Asn Gly Asp Lys  Lys Leu Pro Leu Asp  Ala Asp Ala 
    1265                 1270                 1275             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Gly Leu Trp  Asn Ile Arg 
    1280                 1285                 1290             


Gln Ile  Lys Gln Thr Lys Asn  Lys Asp Asp Leu Asn  Leu Ser Ile 
    1295                 1300                 1305             


Ser Ser  Thr Glu Trp Leu Asp  Phe Val Arg Glu Lys  Pro Tyr Leu 
    1310                 1315                 1320             


Lys 
    


<210>  30
<211>  1484
<212>  PRT
<213>  Unknown

<220>
<223>  Peregrinibacteria bacterium


<220>
<221>  MISC_FEATURE
<222>  (1073)..(1073)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Met Ser Asn Phe Phe Lys Asn Phe Thr Asn Leu Tyr Glu Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Asp Thr Leu Thr Asn Met 
            20                  25                  30          


Lys Asp His Leu Glu Tyr Asp Glu Lys Leu Gln Thr Phe Leu Lys Asp 
        35                  40                  45              


Gln Asn Ile Asp Asp Ala Tyr Gln Ala Leu Lys Pro Gln Phe Asp Glu 
    50                  55                  60                  


Ile His Glu Glu Phe Ile Thr Asp Ser Leu Glu Ser Lys Lys Ala Lys 
65                  70                  75                  80  


Glu Ile Asp Phe Ser Glu Tyr Leu Asp Leu Phe Gln Glu Lys Lys Glu 
                85                  90                  95      


Leu Asn Asp Ser Glu Lys Lys Leu Arg Asn Lys Ile Gly Glu Thr Phe 
            100                 105                 110         


Asn Lys Ala Gly Glu Lys Trp Lys Lys Glu Lys Tyr Pro Gln Tyr Glu 
        115                 120                 125             


Trp Lys Lys Gly Ser Lys Ile Ala Asn Gly Ala Asp Ile Leu Ser Cys 
    130                 135                 140                 


Gln Asp Met Leu Gln Phe Ile Lys Tyr Lys Asn Pro Glu Asp Glu Lys 
145                 150                 155                 160 


Ile Lys Asn Tyr Ile Asp Asp Thr Leu Lys Gly Phe Phe Thr Tyr Phe 
                165                 170                 175     


Gly Gly Phe Asn Gln Asn Arg Ala Asn Tyr Tyr Glu Thr Lys Lys Glu 
            180                 185                 190         


Ala Ser Thr Ala Val Ala Thr Arg Ile Val His Glu Asn Leu Pro Lys 
        195                 200                 205             


Phe Cys Asp Asn Val Ile Gln Phe Lys His Ile Ile Lys Arg Lys Lys 
    210                 215                 220                 


Asp Gly Thr Val Glu Lys Thr Glu Arg Lys Thr Glu Tyr Leu Asn Ala 
225                 230                 235                 240 


Tyr Gln Tyr Leu Lys Asn Asn Asn Lys Ile Thr Gln Ile Lys Asp Ala 
                245                 250                 255     


Glu Thr Glu Lys Met Ile Glu Ser Thr Pro Ile Ala Glu Lys Ile Phe 
            260                 265                 270         


Asp Val Tyr Tyr Phe Ser Ser Cys Leu Ser Gln Lys Gln Ile Glu Glu 
        275                 280                 285             


Tyr Asn Arg Ile Ile Gly His Tyr Asn Leu Leu Ile Asn Leu Tyr Asn 
    290                 295                 300                 


Gln Ala Lys Arg Ser Glu Gly Lys His Leu Ser Ala Asn Glu Lys Lys 
305                 310                 315                 320 


Tyr Lys Asp Leu Pro Lys Phe Lys Thr Leu Tyr Lys Gln Ile Gly Cys 
                325                 330                 335     


Gly Lys Lys Lys Asp Leu Phe Tyr Thr Ile Lys Cys Asp Thr Glu Glu 
            340                 345                 350         


Glu Ala Asn Lys Ser Arg Asn Glu Gly Lys Glu Ser His Ser Val Glu 
        355                 360                 365             


Glu Ile Ile Asn Lys Ala Gln Glu Ala Ile Asn Lys Tyr Phe Lys Ser 
    370                 375                 380                 


Asn Asn Asp Cys Glu Asn Ile Asn Thr Val Pro Asp Phe Ile Asn Tyr 
385                 390                 395                 400 


Ile Leu Thr Lys Glu Asn Tyr Glu Gly Val Tyr Trp Ser Lys Ala Ala 
                405                 410                 415     


Met Asn Thr Ile Ser Asp Lys Tyr Phe Ala Asn Tyr His Asp Leu Gln 
            420                 425                 430         


Asp Arg Leu Lys Glu Ala Lys Val Phe Gln Lys Ala Asp Lys Lys Ser 
        435                 440                 445             


Glu Asp Asp Ile Lys Ile Pro Glu Ala Ile Glu Leu Ser Gly Leu Phe 
    450                 455                 460                 


Gly Val Leu Asp Ser Leu Ala Asp Trp Gln Thr Thr Leu Phe Lys Ser 
465                 470                 475                 480 


Ser Ile Leu Ser Asn Glu Lys Leu Lys Ile Ile Thr Asp Ser Gln Thr 
                485                 490                 495     


Pro Ser Glu Ala Leu Leu Lys Met Ile Phe Asn Asp Ile Glu Lys Asn 
            500                 505                 510         


Met Glu Ser Phe Leu Lys Glu Thr Asn Asp Ile Ile Thr Leu Lys Lys 
        515                 520                 525             


Tyr Lys Gly Asn Lys Glu Gly Thr Glu Lys Ile Lys Gln Trp Phe Asp 
    530                 535                 540                 


Tyr Thr Leu Ala Ile Asn Arg Met Leu Lys Tyr Phe Leu Val Lys Glu 
545                 550                 555                 560 


Asn Lys Ile Lys Gly Asn Ser Leu Asp Thr Asn Ile Ser Glu Ala Leu 
                565                 570                 575     


Lys Thr Leu Ile Tyr Ser Asp Asp Ala Glu Trp Phe Lys Trp Tyr Asp 
            580                 585                 590         


Ala Leu Arg Asn Tyr Leu Thr Gln Lys Pro Gln Asp Glu Ala Lys Glu 
        595                 600                 605             


Asn Lys Leu Lys Leu Asn Phe Asp Asn Pro Ser Leu Ala Gly Gly Trp 
    610                 615                 620                 


Asp Val Asn Lys Glu Cys Ser Asn Phe Cys Val Ile Leu Lys Asp Lys 
625                 630                 635                 640 


Asn Glu Lys Lys Tyr Leu Ala Met Ile Lys Lys Gly Glu Asn Thr Leu 
                645                 650                 655     


Phe Gln Lys Glu Trp Thr Glu Gly Arg Gly Lys Asn Leu Thr Lys Lys 
            660                 665                 670         


Ser Asn Pro Leu Phe Glu Ile Asn Asn Cys Glu Ile Leu Ser Lys Met 
        675                 680                 685             


Glu Tyr Asp Phe Trp Ala Asp Val Ser Lys Met Ile Pro Lys Cys Ser 
    690                 695                 700                 


Thr Gln Leu Lys Ala Val Val Asn His Phe Lys Gln Ser Asp Asn Glu 
705                 710                 715                 720 


Phe Ile Phe Pro Ile Gly Tyr Lys Val Thr Ser Gly Glu Lys Phe Arg 
                725                 730                 735     


Glu Glu Cys Lys Ile Ser Lys Gln Asp Phe Glu Leu Asn Asn Lys Val 
            740                 745                 750         


Phe Asn Lys Asn Glu Leu Ser Val Thr Ala Met Arg Tyr Asp Leu Ser 
        755                 760                 765             


Ser Thr Gln Glu Lys Gln Tyr Ile Lys Ala Phe Gln Lys Glu Tyr Trp 
    770                 775                 780                 


Glu Leu Leu Phe Lys Gln Glu Lys Arg Asp Thr Lys Leu Thr Asn Asn 
785                 790                 795                 800 


Glu Ile Phe Asn Glu Trp Ile Asn Phe Cys Asn Lys Lys Tyr Ser Glu 
                805                 810                 815     


Leu Leu Ser Trp Glu Arg Lys Tyr Lys Asp Ala Leu Thr Asn Trp Ile 
            820                 825                 830         


Asn Phe Cys Lys Tyr Phe Leu Ser Lys Tyr Pro Lys Thr Thr Leu Phe 
        835                 840                 845             


Asn Tyr Ser Phe Lys Glu Ser Glu Asn Tyr Asn Ser Leu Asp Glu Phe 
    850                 855                 860                 


Tyr Arg Asp Val Asp Ile Cys Ser Tyr Lys Leu Asn Ile Asn Thr Thr 
865                 870                 875                 880 


Ile Asn Lys Ser Ile Leu Asp Arg Leu Val Glu Glu Gly Lys Leu Tyr 
                885                 890                 895     


Leu Phe Glu Ile Lys Asn Gln Asp Ser Asn Asp Gly Lys Ser Ile Gly 
            900                 905                 910         


His Lys Asn Asn Leu His Thr Ile Tyr Trp Asn Ala Ile Phe Glu Asn 
        915                 920                 925             


Phe Asp Asn Arg Pro Lys Leu Asn Gly Glu Ala Glu Ile Phe Tyr Arg 
    930                 935                 940                 


Lys Ala Ile Ser Lys Asp Lys Leu Gly Ile Val Lys Gly Lys Lys Thr 
945                 950                 955                 960 


Lys Asn Gly Thr Trp Ile Ile Lys Asn Tyr Arg Phe Ser Lys Glu Lys 
                965                 970                 975     


Phe Ile Leu His Val Pro Ile Thr Leu Asn Phe Cys Ser Asn Asn Glu 
            980                 985                 990         


Tyr Val Asn Asp Ile Val Asn Thr  Lys Phe Tyr Asn Phe  Ser Asn Leu 
        995                 1000                 1005             


His Phe  Leu Gly Ile Asp Arg  Gly Glu Lys His Leu  Ala Tyr Tyr 
    1010                 1015                 1020             


Ser Leu  Val Asn Lys Asn Gly  Glu Ile Val Asp Gln  Gly Thr Leu 
    1025                 1030                 1035             


Asn Leu  Pro Phe Thr Asp Lys  Asp Gly Asn Gln Arg  Ser Ile Lys 
    1040                 1045                 1050             


Lys Glu  Lys Tyr Phe Tyr Asn  Lys Gln Glu Asp Lys  Trp Glu Ala 
    1055                 1060                 1065             


Lys Glu  Val Asp Xaa Trp Asn  Tyr Asn Asp Leu Leu  Asp Ala Met 
    1070                 1075                 1080             


Ala Ser  Asn Arg Asp Met Ala  Arg Lys Asn Trp Gln  Arg Ile Gly 
    1085                 1090                 1095             


Thr Ile  Lys Glu Ala Lys Asn  Gly Tyr Val Ser Leu  Val Ile Arg 
    1100                 1105                 1110             


Lys Ile  Ala Asp Leu Ala Val  Asn Asn Glu Arg Pro  Ala Phe Ile 
    1115                 1120                 1125             


Val Leu  Glu Asp Leu Asn Thr  Gly Phe Lys Arg Ser  Arg Gln Lys 
    1130                 1135                 1140             


Ile Asp  Lys Ser Val Tyr Gln  Lys Phe Glu Leu Ala  Leu Ala Lys 
    1145                 1150                 1155             


Lys Leu  Asn Phe Leu Val Asp  Lys Asn Ala Lys Arg  Asp Glu Ile 
    1160                 1165                 1170             


Gly Ser  Pro Thr Lys Ala Leu  Gln Leu Thr Pro Pro  Val Asn Asn 
    1175                 1180                 1185             


Tyr Gly  Asp Ile Glu Asn Lys  Lys Gln Ala Gly Ile  Met Leu Tyr 
    1190                 1195                 1200             


Thr Arg  Ala Asn Tyr Thr Ser  Gln Thr Asp Pro Ala  Thr Gly Trp 
    1205                 1210                 1215             


Arg Lys  Thr Ile Tyr Leu Lys  Ala Gly Pro Glu Glu  Thr Thr Tyr 
    1220                 1225                 1230             


Lys Lys  Asp Gly Lys Ile Lys  Asn Lys Ser Val Lys  Asp Gln Ile 
    1235                 1240                 1245             


Ile Glu  Thr Phe Thr Asp Ile  Gly Phe Asp Gly Lys  Asp Tyr Tyr 
    1250                 1255                 1260             


Phe Glu  Tyr Asp Lys Gly Glu  Phe Val Asp Glu Lys  Thr Gly Glu 
    1265                 1270                 1275             


Ile Lys  Pro Lys Lys Trp Arg  Leu Tyr Ser Gly Glu  Asn Gly Lys 
    1280                 1285                 1290             


Ser Leu  Asp Arg Phe Arg Gly  Glu Arg Glu Lys Asp  Lys Tyr Glu 
    1295                 1300                 1305             


Trp Lys  Ile Asp Lys Ile Asp  Ile Val Lys Ile Leu  Asp Asp Leu 
    1310                 1315                 1320             


Phe Val  Asn Phe Asp Lys Asn  Ile Ser Leu Leu Lys  Gln Leu Lys 
    1325                 1330                 1335             


Glu Gly  Val Glu Leu Thr Arg  Asn Asn Glu His Gly  Thr Gly Glu 
    1340                 1345                 1350             


Ser Leu  Arg Phe Ala Ile Asn  Leu Ile Gln Gln Ile  Arg Asn Thr 
    1355                 1360                 1365             


Gly Asn  Asn Glu Arg Asp Asn  Asp Phe Ile Leu Ser  Pro Val Arg 
    1370                 1375                 1380             


Asp Glu  Asn Gly Lys His Phe  Asp Ser Arg Glu Tyr  Trp Asp Lys 
    1385                 1390                 1395             


Glu Thr  Lys Gly Glu Lys Ile  Ser Met Pro Ser Ser  Gly Asp Ala 
    1400                 1405                 1410             


Asn Gly  Ala Phe Asn Ile Ala  Arg Lys Gly Ile Ile  Met Asn Ala 
    1415                 1420                 1425             


His Ile  Leu Ala Asn Ser Asp  Ser Lys Asp Leu Ser  Leu Phe Val 
    1430                 1435                 1440             


Ser Asp  Glu Glu Trp Asp Leu  His Leu Asn Asn Lys  Thr Glu Trp 
    1445                 1450                 1455             


Lys Lys  Gln Leu Asn Ile Phe  Ser Ser Arg Lys Ala  Met Ala Lys 
    1460                 1465                 1470             


Arg Lys  Lys Lys Arg Pro Ala  Ala Thr Lys Lys 
    1475                 1480                 


<210>  31
<211>  1245
<212>  PRT
<213>  Porphyromonas macacae

<400>  31

Met Lys Thr Gln His Phe Phe Glu Asp Phe Thr Ser Leu Tyr Ser Leu 
1               5                   10                  15      


Ser Lys Thr Ile Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu 
            20                  25                  30          


Asn Ile Lys Lys Asn Gly Leu Ile Arg Arg Asp Glu Gln Arg Leu Asp 
        35                  40                  45              


Asp Tyr Glu Lys Leu Lys Lys Val Ile Asp Glu Tyr His Glu Asp Phe 
    50                  55                  60                  


Ile Ala Asn Ile Leu Ser Ser Phe Ser Phe Ser Glu Glu Ile Leu Gln 
65                  70                  75                  80  


Ser Tyr Ile Gln Asn Leu Ser Ile Ser Glu Ala Arg Ala Lys Ile Glu 
                85                  90                  95      


Lys Thr Met Arg Asp Thr Leu Ala Lys Ala Phe Ser Glu Asp Glu Arg 
            100                 105                 110         


Tyr Lys Ser Ile Phe Lys Lys Glu Leu Val Lys Lys Asp Ile Pro Val 
        115                 120                 125             


Trp Cys Pro Ala Tyr Lys Ser Leu Cys Lys Lys Phe Asp Asn Phe Thr 
    130                 135                 140                 


Thr Ser Leu Val Pro Phe His Glu Asn Arg Lys Asn Leu Tyr Thr Ser 
145                 150                 155                 160 


Asn Glu Ile Thr Ala Ser Ile Pro Tyr Arg Ile Val His Val Asn Leu 
                165                 170                 175     


Pro Lys Phe Ile Gln Asn Ile Glu Ala Leu Cys Glu Leu Gln Lys Lys 
            180                 185                 190         


Met Gly Ala Asp Leu Tyr Leu Glu Met Met Glu Asn Leu Arg Asn Val 
        195                 200                 205             


Trp Pro Ser Phe Val Lys Thr Pro Asp Asp Leu Cys Asn Leu Lys Thr 
    210                 215                 220                 


Tyr Asn His Leu Met Val Gln Ser Ser Ile Ser Glu Tyr Asn Arg Phe 
225                 230                 235                 240 


Val Gly Gly Tyr Ser Thr Glu Asp Gly Thr Lys His Gln Gly Ile Asn 
                245                 250                 255     


Glu Trp Ile Asn Ile Tyr Arg Gln Arg Asn Lys Glu Met Arg Leu Pro 
            260                 265                 270         


Gly Leu Val Phe Leu His Lys Gln Ile Leu Ala Lys Val Asp Ser Ser 
        275                 280                 285             


Ser Phe Ile Ser Asp Thr Leu Glu Asn Asp Asp Gln Val Phe Cys Val 
    290                 295                 300                 


Leu Arg Gln Phe Arg Lys Leu Phe Trp Asn Thr Val Ser Ser Lys Glu 
305                 310                 315                 320 


Asp Asp Ala Ala Ser Leu Lys Asp Leu Phe Cys Gly Leu Ser Gly Tyr 
                325                 330                 335     


Asp Pro Glu Ala Ile Tyr Val Ser Asp Ala His Leu Ala Thr Ile Ser 
            340                 345                 350         


Lys Asn Ile Phe Asp Arg Trp Asn Tyr Ile Ser Asp Ala Ile Arg Arg 
        355                 360                 365             


Lys Thr Glu Val Leu Met Pro Arg Lys Lys Glu Ser Val Glu Arg Tyr 
    370                 375                 380                 


Ala Glu Lys Ile Ser Lys Gln Ile Lys Lys Arg Gln Ser Tyr Ser Leu 
385                 390                 395                 400 


Ala Glu Leu Asp Asp Leu Leu Ala His Tyr Ser Glu Glu Ser Leu Pro 
                405                 410                 415     


Ala Gly Phe Ser Leu Leu Ser Tyr Phe Thr Ser Leu Gly Gly Gln Lys 
            420                 425                 430         


Tyr Leu Val Ser Asp Gly Glu Val Ile Leu Tyr Glu Glu Gly Ser Asn 
        435                 440                 445             


Ile Trp Asp Glu Val Leu Ile Ala Phe Arg Asp Leu Gln Val Ile Leu 
    450                 455                 460                 


Asp Lys Asp Phe Thr Glu Lys Lys Leu Gly Lys Asp Glu Glu Ala Val 
465                 470                 475                 480 


Ser Val Ile Lys Lys Ala Leu Asp Ser Ala Leu Arg Leu Arg Lys Phe 
                485                 490                 495     


Phe Asp Leu Leu Ser Gly Thr Gly Ala Glu Ile Arg Arg Asp Ser Ser 
            500                 505                 510         


Phe Tyr Ala Leu Tyr Thr Asp Arg Met Asp Lys Leu Lys Gly Leu Leu 
        515                 520                 525             


Lys Met Tyr Asp Lys Val Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser 
    530                 535                 540                 


Ile Glu Lys Phe Lys Leu His Phe Asp Asn Pro Ser Leu Leu Ser Gly 
545                 550                 555                 560 


Trp Asp Lys Asn Lys Glu Leu Asn Asn Leu Ser Val Ile Phe Arg Gln 
                565                 570                 575     


Asn Gly Tyr Tyr Tyr Leu Gly Ile Met Thr Pro Lys Gly Lys Asn Leu 
            580                 585                 590         


Phe Lys Thr Leu Pro Lys Leu Gly Ala Glu Glu Met Phe Tyr Glu Lys 
        595                 600                 605             


Met Glu Tyr Lys Gln Ile Ala Glu Pro Met Leu Met Leu Pro Lys Val 
    610                 615                 620                 


Phe Phe Pro Lys Lys Thr Lys Pro Ala Phe Ala Pro Asp Gln Ser Val 
625                 630                 635                 640 


Val Asp Ile Tyr Asn Lys Lys Thr Phe Lys Thr Gly Gln Lys Gly Phe 
                645                 650                 655     


Asn Lys Lys Asp Leu Tyr Arg Leu Ile Asp Phe Tyr Lys Glu Ala Leu 
            660                 665                 670         


Thr Val His Glu Trp Lys Leu Phe Asn Phe Ser Phe Ser Pro Thr Glu 
        675                 680                 685             


Gln Tyr Arg Asn Ile Gly Glu Phe Phe Asp Glu Val Arg Glu Gln Ala 
    690                 695                 700                 


Tyr Lys Val Ser Met Val Asn Val Pro Ala Ser Tyr Ile Asp Glu Ala 
705                 710                 715                 720 


Val Glu Asn Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
                725                 730                 735     


Ser Pro Tyr Ser Lys Gly Ile Pro Asn Leu His Thr Leu Tyr Trp Lys 
            740                 745                 750         


Ala Leu Phe Ser Glu Gln Asn Gln Ser Arg Val Tyr Lys Leu Cys Gly 
        755                 760                 765             


Gly Gly Glu Leu Phe Tyr Arg Lys Ala Ser Leu His Met Gln Asp Thr 
    770                 775                 780                 


Thr Val His Pro Lys Gly Ile Ser Ile His Lys Lys Asn Leu Asn Lys 
785                 790                 795                 800 


Lys Gly Glu Thr Ser Leu Phe Asn Tyr Asp Leu Val Lys Asp Lys Arg 
                805                 810                 815     


Phe Thr Glu Asp Lys Phe Phe Phe His Val Pro Ile Ser Ile Asn Tyr 
            820                 825                 830         


Lys Asn Lys Lys Ile Thr Asn Val Asn Gln Met Val Arg Asp Tyr Ile 
        835                 840                 845             


Ala Gln Asn Asp Asp Leu Gln His Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Ile Ser Arg Ile Asp Thr Arg Gly Asn Leu Leu Glu Gln 
865                 870                 875                 880 


Phe Ser Leu Asn Val Ile Glu Ser Asp Lys Gly Asp Leu Arg Thr Asp 
                885                 890                 895     


Tyr Gln Lys Ile Leu Gly Asp Arg Glu Gln Glu Arg Leu Arg Arg Arg 
            900                 905                 910         


Gln Glu Trp Lys Ser Ile Glu Ser Ile Lys Asp Leu Lys Asp Gly Tyr 
        915                 920                 925             


Met Ser Gln Val Val His Lys Ile Cys Asn Met Val Val Glu His Lys 
    930                 935                 940                 


Ala Ile Val Val Leu Glu Asn Leu Asn Leu Ser Phe Met Lys Gly Arg 
945                 950                 955                 960 


Lys Lys Val Glu Lys Ser Val Tyr Glu Lys Phe Glu Arg Met Leu Val 
                965                 970                 975     


Asp Lys Leu Asn Tyr Leu Val Val Asp Lys Lys Asn Leu Ser Asn Glu 
            980                 985                 990         


Pro Gly Gly Leu Tyr Ala Ala Tyr  Gln Leu Thr Asn Pro  Leu Phe Ser 
        995                 1000                 1005             


Phe Glu  Glu Leu His Arg Tyr  Pro Gln Ser Gly Ile  Leu Phe Phe 
    1010                 1015                 1020             


Val Asp  Pro Trp Asn Thr Ser  Leu Thr Asp Pro Ser  Thr Gly Phe 
    1025                 1030                 1035             


Val Asn  Leu Leu Gly Arg Ile  Asn Tyr Thr Asn Val  Gly Asp Ala 
    1040                 1045                 1050             


Arg Lys  Phe Phe Asp Arg Phe  Asn Ala Ile Arg Tyr  Asp Gly Lys 
    1055                 1060                 1065             


Gly Asn  Ile Leu Phe Asp Leu  Asp Leu Ser Arg Phe  Asp Val Arg 
    1070                 1075                 1080             


Val Glu  Thr Gln Arg Lys Leu  Trp Thr Leu Thr Thr  Phe Gly Ser 
    1085                 1090                 1095             


Arg Ile  Ala Lys Ser Lys Lys  Ser Gly Lys Trp Met  Val Glu Arg 
    1100                 1105                 1110             


Ile Glu  Asn Leu Ser Leu Cys  Phe Leu Glu Leu Phe  Glu Gln Phe 
    1115                 1120                 1125             


Asn Ile  Gly Tyr Arg Val Glu  Lys Asp Leu Lys Lys  Ala Ile Leu 
    1130                 1135                 1140             


Ser Gln  Asp Arg Lys Glu Phe  Tyr Val Arg Leu Ile  Tyr Leu Phe 
    1145                 1150                 1155             


Asn Leu  Met Met Gln Ile Arg  Asn Ser Asp Gly Glu  Glu Asp Tyr 
    1160                 1165                 1170             


Ile Leu  Ser Pro Ala Leu Asn  Glu Lys Asn Leu Gln  Phe Asp Ser 
    1175                 1180                 1185             


Arg Leu  Ile Glu Ala Lys Asp  Leu Pro Val Asp Ala  Asp Ala Asn 
    1190                 1195                 1200             


Gly Ala  Tyr Asn Val Ala Arg  Lys Gly Leu Met Val  Val Gln Arg 
    1205                 1210                 1215             


Ile Lys  Arg Gly Asp His Glu  Ser Ile His Arg Ile  Gly Arg Ala 
    1220                 1225                 1230             


Gln Trp  Leu Arg Tyr Val Gln  Glu Gly Ile Val Glu  
    1235                 1240                 1245 


<210>  32
<211>  1250
<212>  PRT
<213>  Smithella sp.

<400>  32

Met Gln Thr Leu Phe Glu Asn Phe Thr Asn Gln Tyr Pro Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Lys Asp Phe Ile 
            20                  25                  30          


Glu Gln Lys Gly Leu Leu Lys Lys Asp Glu Asp Arg Ala Glu Lys Tyr 
        35                  40                  45              


Lys Lys Val Lys Asn Ile Ile Asp Glu Tyr His Lys Asp Phe Ile Glu 
    50                  55                  60                  


Lys Ser Leu Asn Gly Leu Lys Leu Asp Gly Leu Glu Lys Tyr Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Lys Gln Glu Lys Asp Asp Lys Asp Lys Lys Ala Phe Asp 
                85                  90                  95      


Lys Glu Lys Glu Asn Leu Arg Lys Gln Ile Ala Asn Ala Phe Arg Asn 
            100                 105                 110         


Asn Glu Lys Phe Lys Thr Leu Phe Ala Lys Glu Leu Ile Lys Asn Asp 
        115                 120                 125             


Leu Met Ser Phe Ala Cys Glu Glu Asp Lys Lys Asn Val Lys Glu Phe 
    130                 135                 140                 


Glu Ala Phe Thr Thr Tyr Phe Thr Gly Phe His Gln Asn Arg Ala Asn 
145                 150                 155                 160 


Met Tyr Val Ala Asp Glu Lys Arg Thr Ala Ile Ala Ser Arg Leu Ile 
                165                 170                 175     


His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Lys Ile Phe Glu Lys 
            180                 185                 190         


Met Lys Lys Glu Ala Pro Glu Leu Leu Ser Pro Phe Asn Gln Thr Leu 
        195                 200                 205             


Lys Asp Met Lys Asp Val Ile Lys Gly Thr Thr Leu Glu Glu Ile Phe 
    210                 215                 220                 


Ser Leu Asp Tyr Phe Asn Lys Thr Leu Thr Gln Ser Gly Ile Asp Ile 
225                 230                 235                 240 


Tyr Asn Ser Val Ile Gly Gly Arg Thr Pro Glu Glu Gly Lys Thr Lys 
                245                 250                 255     


Ile Lys Gly Leu Asn Glu Tyr Ile Asn Thr Asp Phe Asn Gln Lys Gln 
            260                 265                 270         


Thr Asp Lys Lys Lys Arg Gln Pro Lys Phe Lys Gln Leu Tyr Lys Gln 
        275                 280                 285             


Ile Leu Ser Asp Arg Gln Ser Leu Ser Phe Ile Ala Glu Ala Phe Lys 
    290                 295                 300                 


Asn Asp Thr Glu Ile Leu Glu Ala Ile Glu Lys Phe Tyr Val Asn Glu 
305                 310                 315                 320 


Leu Leu His Phe Ser Asn Glu Gly Lys Ser Thr Asn Val Leu Asp Ala 
                325                 330                 335     


Ile Lys Asn Ala Val Ser Asn Leu Glu Ser Phe Asn Leu Thr Lys Met 
            340                 345                 350         


Tyr Phe Arg Ser Gly Ala Ser Leu Thr Asp Val Ser Arg Lys Val Phe 
        355                 360                 365             


Gly Glu Trp Ser Ile Ile Asn Arg Ala Leu Asp Asn Tyr Tyr Ala Thr 
    370                 375                 380                 


Thr Tyr Pro Ile Lys Pro Arg Glu Lys Ser Glu Lys Tyr Glu Glu Arg 
385                 390                 395                 400 


Lys Glu Lys Trp Leu Lys Gln Asp Phe Asn Val Ser Leu Ile Gln Thr 
                405                 410                 415     


Ala Ile Asp Glu Tyr Asp Asn Glu Thr Val Lys Gly Lys Asn Ser Gly 
            420                 425                 430         


Lys Val Ile Ala Asp Tyr Phe Ala Lys Phe Cys Asp Asp Lys Glu Thr 
        435                 440                 445             


Asp Leu Ile Gln Lys Val Asn Glu Gly Tyr Ile Ala Val Lys Asp Leu 
    450                 455                 460                 


Leu Asn Thr Pro Cys Pro Glu Asn Glu Lys Leu Gly Ser Asn Lys Asp 
465                 470                 475                 480 


Gln Val Lys Gln Ile Lys Ala Phe Met Asp Ser Ile Met Asp Ile Met 
                485                 490                 495     


His Phe Val Arg Pro Leu Ser Leu Lys Asp Thr Asp Lys Glu Lys Asp 
            500                 505                 510         


Glu Thr Phe Tyr Ser Leu Phe Thr Pro Leu Tyr Asp His Leu Thr Gln 
        515                 520                 525             


Thr Ile Ala Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Gln Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Asn Ser Thr Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Leu Asn Lys Glu Thr Asp Asn Thr Ala Ile Ile Leu 
                565                 570                 575     


Arg Lys Asp Asn Leu Tyr Tyr Leu Gly Ile Met Asp Lys Arg His Asn 
            580                 585                 590         


Arg Ile Phe Arg Asn Val Pro Lys Ala Asp Lys Lys Asp Phe Cys Tyr 
        595                 600                 605             


Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ser Gln Ser Arg Ile Gln Glu Phe Thr Pro Ser Ala 
625                 630                 635                 640 


Lys Leu Leu Glu Asn Tyr Ala Asn Glu Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Asn His Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser 
            660                 665                 670         


Ile Asn Lys His Glu Asp Trp Lys Asn Phe Asp Phe Arg Phe Ser Ala 
        675                 680                 685             


Thr Ser Thr Tyr Ala Asp Leu Ser Gly Phe Tyr His Glu Val Glu His 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Ser Phe Gln Ser Val Ala Asp Ser Phe Ile Asp 
705                 710                 715                 720 


Asp Leu Val Asn Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Phe Ser Lys Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Trp Lys Met Leu Phe Asp Glu Asn Asn Leu Lys Asp Val Val Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg Lys Lys Ser Ile Ala Glu 
    770                 775                 780                 


Lys Asn Thr Thr Ile His Lys Ala Asn Glu Ser Ile Ile Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Ala Thr Ser Thr Phe Asn Tyr Asp Ile Val Lys 
                805                 810                 815     


Asp Lys Arg Tyr Thr Ile Asp Lys Phe Gln Phe His Ile Pro Ile Thr 
            820                 825                 830         


Met Asn Phe Lys Ala Glu Gly Ile Phe Asn Met Asn Gln Arg Val Asn 
        835                 840                 845             


Gln Phe Leu Lys Ala Asn Pro Asp Ile Asn Ile Ile Gly Ile Asp Arg 
    850                 855                 860                 


Gly Glu Arg His Leu Leu Tyr Tyr Ala Leu Ile Asn Gln Lys Gly Lys 
865                 870                 875                 880 


Ile Leu Lys Gln Asp Thr Leu Asn Val Ile Ala Asn Glu Lys Gln Lys 
                885                 890                 895     


Val Asp Tyr His Asn Leu Leu Asp Lys Lys Glu Gly Asp Arg Ala Thr 
            900                 905                 910         


Ala Arg Gln Glu Trp Gly Val Ile Glu Thr Ile Lys Glu Leu Lys Glu 
        915                 920                 925             


Gly Tyr Leu Ser Gln Val Ile His Lys Leu Thr Asp Leu Met Ile Glu 
    930                 935                 940                 


Asn Asn Ala Ile Ile Val Met Glu Asp Leu Asn Phe Gly Phe Lys Arg 
945                 950                 955                 960 


Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
                965                 970                 975     


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Asn Lys Lys Ala Asn 
            980                 985                 990         


Glu Leu Gly Gly Leu Leu Asn Ala  Phe Gln Leu Ala Asn  Lys Phe Glu 
        995                 1000                 1005             


Ser Phe  Gln Lys Met Gly Lys  Gln Asn Gly Phe Ile  Phe Tyr Val 
    1010                 1015                 1020             


Pro Ala  Trp Asn Thr Ser Lys  Thr Asp Pro Ala Thr  Gly Phe Ile 
    1025                 1030                 1035             


Asp Phe  Leu Lys Pro Arg Tyr  Glu Asn Leu Asn Gln  Ala Lys Asp 
    1040                 1045                 1050             


Phe Phe  Glu Lys Phe Asp Ser  Ile Arg Leu Asn Ser  Lys Ala Asp 
    1055                 1060                 1065             


Tyr Phe  Glu Phe Ala Phe Asp  Phe Lys Asn Phe Thr  Glu Lys Ala 
    1070                 1075                 1080             


Asp Gly  Gly Arg Thr Lys Trp  Thr Val Cys Thr Thr  Asn Glu Asp 
    1085                 1090                 1095             


Arg Tyr  Gln Trp Asn Arg Ala  Leu Asn Asn Asn Arg  Gly Ser Gln 
    1100                 1105                 1110             


Glu Lys  Tyr Asp Ile Thr Ala  Glu Leu Lys Ser Leu  Phe Asp Gly 
    1115                 1120                 1125             


Lys Val  Asp Tyr Lys Ser Gly  Lys Asp Leu Lys Gln  Gln Ile Ala 
    1130                 1135                 1140             


Ser Gln  Glu Ser Ala Asp Phe  Phe Lys Ala Leu Met  Lys Asn Leu 
    1145                 1150                 1155             


Ser Ile  Thr Leu Ser Leu Arg  His Asn Asn Gly Glu  Lys Gly Asp 
    1160                 1165                 1170             


Asn Glu  Gln Asp Tyr Ile Leu  Ser Pro Val Ala Asp  Ser Lys Gly 
    1175                 1180                 1185             


Arg Phe  Phe Asp Ser Arg Lys  Ala Asp Asp Asp Met  Pro Lys Asn 
    1190                 1195                 1200             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1205                 1210                 1215             


Cys Leu  Glu Gln Ile Ser Lys  Thr Asp Asp Leu Lys  Lys Val Lys 
    1220                 1225                 1230             


Leu Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Phe Val  Gln Thr Leu 
    1235                 1240                 1245             


Lys Gly  
    1250 


<210>  33
<211>  3987
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas12a polynucleotide

<400>  33
atggccggga gcaagaagcg ccggataaag caggacacgc agttcgaggg cttcaccaac       60

ctgtaccaag tctccaagac gctccggttc gagcttatcc cgcaagggaa gaccctgaaa      120

cacatccagg aacaaggttt catcgaggag gacaaggccc gcaacgacca ctacaaggag      180

ctcaagccca taatcgatcg gatctacaag acgtacgccg accagtgcct ccaactggtg      240

cagctcgact gggagaacct gagcgccgcc attgacagct accgcaagga aaagacggag      300

gagacgcgca acgcccttat tgaggagcaa gccacctacc gcaacgccat ccacgactac      360

ttcatcgggc gcaccgacaa cctgacggac gcgatcaaca agcgccacgc ggaaatctac      420

aagggccttt tcaaggccga gctcttcaac gggaaggtcc taaaacagct cgggactgtc      480

acgacaaccg agcatgagaa cgccctcctt cgcagcttcg acaagttcac cacatacttc      540

tcgggcttct accggaaccg caagaacgtt ttcagcgccg aggacatctc caccgccatc      600

ccgcacagga tcgtccagga caacttcccc aagttcaagg agaactgcca catcttcacg      660

cgcctgatta cagccgtacc ttcacttcgt gagcacttcg agaacgtcaa aaaggccatc      720

gggatcttcg tctccacgtc catcgaggag gtattctctt tcccgttcta taaccagctc      780

ctgacccaga cgcagatcga cctctacaac cagctactgg gcggcatcag ccgggaggcc      840

gggaccgaga aaataaaggg cctcaacgaa gttctcaacc tggccatcca gaagaacgac      900

gagaccgcgc atatcatcgc atccctgccg catcgcttca ttcctttgtt caagcagata      960

ttgagcgacc ggaacaccct ctcgttcatc ctcgaagaat tcaagagcga cgaggaggtc     1020

attcagtctt tctgcaagta caagacgctc ctacggaatg agaatgtgct ggagaccgcg     1080

gaggcactct tcaatgagct gaactccatt gacctgaccc acatcttcat tagccacaag     1140

aaactggaga cgatctccag cgccctgtgc gaccactggg acactctccg caacgccctc     1200

tacgaacgcc ggatctccga acttaccggc aagataacta agtcggctaa ggagaaggtg     1260

caacggagcc tcaagcacga ggacatcaac cttcaggaaa tcatctcagc cgcgggcaag     1320

gagctgagcg aggcgtttaa gcagaaaaca tcggagatac tgagccacgc gcacgcggcc     1380

ctggatcaac cgctgccgac gactctcaag aagcaagagg agaaggaaat ccttaagtcc     1440

cagctcgact cgctgctcgg cctctatcac ttgctcgact ggttcgcggt tgatgagtcc     1500

aacgaggtgg acccggagtt ctccgcgcgc ctcacgggta ttaagctgga gatggagcca     1560

agcttaagct tctacaacaa ggcccgcaac tacgcgacca aaaaaccgta ctcagtcgag     1620

aaattcaagc tgaatttcca gatgcctaca ttggcgaggg ggtgggacgt gaaccgcgag     1680

aagaacaatg gagccatcct gttcgtcaaa aatgggttgt actacctggg catcatgccc     1740

aagcagaagg gccgttacaa ggccctgtca ttcgagccta ccgagaagac ctcggagggc     1800

ttcgacaaga tgtactacga ctatttcccg gacgccgcca agatgatccc gaagtgctcc     1860

acgcagctca aagccgtcac ggcccacttc cagacgcata ccacgccgat acttctgagc     1920

aacaacttca ttgagccgct agagatcacg aaggagatat acgacctaaa caaccccgaa     1980

aaggagccca agaagttcca gacagcctac gctaagaaga caggtgatca gaagggatat     2040

agggaggcac tctgcaagtg gatcgacttc acgcgcgact tcctgtcgaa atatacaaag     2100

acgaccagca ttgacctaag ttctctccgc ccatcctccc agtacaagga tctgggcgag     2160

tattatgcgg agctgaaccc attgctgtac cacatcagct tccagaggat cgccgagaag     2220

gagattatgg acgcggtgga gacggggaaa ctatacctgt tccaaatata taacaaggac     2280

ttcgctaaag ggcaccacgg gaagcccaac ctgcacacac tctactggac gggcttgttt     2340

tcgccagaaa atttggccaa gacttcgatc aagctcaacg gccaggcgga gttgttttac     2400

cgtcccaagt ctcgcatgaa gcgcatggcg catcgcctcg gagagaaaat gcttaacaag     2460

aagctcaagg atcagaagac gcccatacct gatacgttgt accaggaatt gtacgactac     2520

gtgaaccacc gcctatcgca cgacctctca gacgaggccc gcgccctcct cccaaacgtg     2580

attactaagg aggtttccca tgaaataatc aaggaccgac ggttcaccag cgacaaattt     2640

tttttccacg tgcctatcac gctcaattac caggcggcca actccccatc gaagttcaac     2700

cagcgcgtga acgcctacct taaggagcac ccggagaccc caatcatcgg gatcgaccgt     2760

ggcgagcgga acctgatcta tattacggtg atcgatagca ccgggaagat cctggagcag     2820

cgctccctga acacaatcca gcagtttgac taccagaaga aactcgacaa ccgggagaag     2880

gagcgcgtcg cagcccggca agcatggagt gtggtcggca ccataaagga cctgaaacag     2940

ggttacctaa gtcaagttat ccacgagatc gttgacctga tgatacacta tcaagccgta     3000

gtcgtgctgg agaacctcaa cttcgggttt aagtccaagc gcaccggcat cgcggagaag     3060

gcggtgtacc agcagttcga gaagatgctg atcgacaagc tgaactgcct ggtgctcaag     3120

gactaccctg cggagaaggt cggcggggtc ttgaacccgt accagctaac cgaccagttc     3180

acgagcttcg ccaaaatggg cacgcagtcc ggattcttgt tttatgtccc ggctccatat     3240

acaagtaaga tcgacccgct gacagggttt gttgacccat tcgtgtggaa gaccatcaag     3300

aaccacgaga gcaggaaaca cttcttagag ggcttcgact tcctgcatta cgacgttaag     3360

acaggcgact tcatcctgca cttcaagatg aaccgcaacc tgtcgttcca gaggggcctg     3420

cccggcttca tgcccgcctg ggatatcgtc tttgagaaga atgagacgca gttcgacgcg     3480

aaggggacgc cgttcatcgc tggaaagcgg atcgtgccgg tcatcgagaa ccaccgcttc     3540

acgggtcgct accgagattt ataccccgcc aacgaactaa ttgcgctgct ggaggagaag     3600

gggatcgtgt tccgagatgg cagcaacatt ctcccgaagc tgctggagaa cgacgactcg     3660

cacgctattg acacgatggt cgccctcata cggagcgtgc ttcagatgcg gaacagtaac     3720

gctgccacgg gcgaggacta cattaactcc cccgtccgcg acctcaacgg ggtctgcttc     3780

gatagccgct tccagaaccc ggagtggcct atggatgcgg acgcgaacgg ggcctaccac     3840

atcgccctca agggccaact cctgctcaac cacttgaagg aaagcaaaga cctcaaattg     3900

cagaatggca tcagtaacca ggactggctc gcgtacatcc aggaactgag aaacgggtcc     3960

aagaagcggc gtatcaagca agattga                                         3987


<210>  34
<211>  3987
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas12a polynucleotide

<400>  34
atggcgggaa gcaaaaagcg ccggattaag caagacacgc agttcgaggg cttcacgaac       60

ctctaccaag tcagcaagac cctccggttc gagctgatac cacagggaaa gacgctcaag      120

cacatccagg aacagggctt catcgaggag gacaaggcgc gcaacgacca ctacaaggag      180

ttgaaaccga tcatcgaccg catctacaag acgtacgccg accagtgcct ccagctcgtg      240

cagctcgact gggagaacct ctccgccgcc attgactcgt accggaagga gaagactgag      300

gagacccgca acgccctgat cgaggagcaa gcaacctacc ggaacgccat ccacgactac      360

ttcatcggcc gcaccgacaa cctcaccgac gcgatcaaca agcggcacgc ggagatatac      420

aaagggctgt tcaaggcgga gctgttcaac ggcaaggtgc tcaagcagct agggacggtg      480

accacgaccg agcacgagaa cgcgctcctc cgcagcttcg acaagttcac cacctacttc      540

agcggcttct accggaaccg caagaatgtg ttcagcgcgg aggacatcag cacggccatc      600

ccgcaccgca tcgtccagga caacttcccg aagttcaagg agaactgcca catcttcacc      660

cgcctgataa ccgccgtccc ctccctgcgg gagcacttcg agaacgtcaa aaaggcaatt      720

gggatcttcg tctcgaccag cattgaggag gtgttcagct tccccttcta caaccagctc      780

ctcacccaga cgcagatcga cctgtacaat cagttgctcg gcgggataag ccgcgaggcg      840

ggaaccgaaa aaatcaaggg gctgaacgaa gtgttgaacc tcgccatcca gaagaacgac      900

gagaccgcgc acatcatcgc ctccctgccc caccggttca tcccgctgtt caagcagatc      960

ctctctgacc ggaacaccct gtccttcatt cttgaggagt tcaagtcgga cgaggaggtc     1020

atccagagct tctgcaagta caagacgctg ctacggaacg agaacgtgct ggagacggcg     1080

gaggcactgt tcaacgagct aaacagcatc gacctcacgc acatcttcat cagtcacaag     1140

aaactggaga ccatctcctc cgcgctgtgc gaccactggg acacgctcag gaacgcgctc     1200

tacgagcgcc gaatcagtga gctgacgggc aagatcacga agtccgcgaa ggagaaggtg     1260

cagcggtccc tcaagcacga ggacatcaac ctccaggaga tcatctcagc ggctgggaaa     1320

gagctgtccg aggcgttcaa gcagaaaacg agcgaaatcc tgtcccacgc gcacgcggcc     1380

ctggatcagc ctctgccgac gaccctcaag aaacaagaag aaaaggaaat cctcaagtcg     1440

cagctcgact cgctgctggg cctgtaccat ctcctcgact ggttcgccgt ggacgagagc     1500

aacgaggtgg accccgagtt ctccgcgcgg cttacgggga tcaagctgga gatggagccc     1560

agcctgtcct tctacaacaa ggcgcgcaac tacgccacca agaagcccta cagcgtggag     1620

aagttcaagc tcaacttcca gatgcccact ctcgcacgtg ggtgggacgt caaccgcgaa     1680

aaaaataatg gggcgatcct gttcgtcaag aacggcctgt actacttggg catcatgccg     1740

aaacagaagg gccgctacaa ggccctgagc ttcgaaccga ccgagaaaac gagcgagggg     1800

ttcgacaaga tgtactacga ctacttcccc gacgccgcga agatgattcc aaagtgctcc     1860

acgcagctta aggccgtgac ggcccacttc cagacgcaca cgaccccgat cctcctcagc     1920

aacaacttca tcgagcccct ggagatcacg aaggagatat acgacctgaa caacccggag     1980

aaggagccca agaaattcca gaccgcctac gccaagaaga caggcgacca aaagggttac     2040

agggaggccc tctgcaagtg gatcgacttc actagggact tcctgtccaa gtacaccaag     2100

actacctcta tcgacctgtc cagcctccgc ccgtcgtccc agtacaaaga tttgggcgag     2160

tattacgcgg agctgaaccc actgctctac cacatcagct tccagcgcat cgcggagaag     2220

gagatcatgg acgcagtgga gacgggcaag ctatacctat ttcagatata caacaaagac     2280

ttcgctaagg gacaccacgg caagcctaac ctgcacaccc tctactggac ggggctcttc     2340

agcccggaga acctcgccaa gacctcgatc aagctcaacg gccaggccga gctgttctac     2400

cggcccaagt cccgcatgaa gcggatggcc caccggctcg gggagaaaat gctcaacaag     2460

aaattgaagg accaaaaaac gccgataccc gacaccctat accaggagct gtacgactat     2520

gtgaaccacc gcctgagcca cgacctcagc gacgaggcgc gggccctcct gccgaacgtc     2580

atcacaaagg aggtcagcca cgagatcatc aaggaccggc gcttcacctc cgacaagttt     2640

ttctttcacg tgcccatcac gctcaactac caggccgcca actcgccgtc caagttcaac     2700

cagcgcgtga acgcctacct caaggagcac cccgagaccc cgatcatcgg gattgaccga     2760

ggggagcgga acctcatcta catcaccgtc atcgacagca ccgggaagat ccttgaacag     2820

cggtcgctca acaccatcca gcagttcgac taccagaaga aactcgacaa ccgggagaag     2880

gagagagtgg cggcccgcca ggcttggtcc gtcgtcggga cgattaagga cttgaaacaa     2940

ggttacctgt cgcaagtgat ccacgagatc gttgacctga tgatccacta ccaagccgtc     3000

gtggtcctgg agaacctcaa cttcggcttc aagagcaaac gaaccggcat cgcggagaag     3060

gccgtgtacc agcagttcga aaaaatgctg atcgacaagc tgaactgcct cgtgctcaag     3120

gactaccccg ctgagaaggt cggcggggtg ctgaacccgt accagctcac tgaccagttc     3180

accagcttcg caaagatggg cacccagtcc ggcttcctgt tctacgtgcc tgcgccatac     3240

acctcgaaga tcgacccgct caccgggttc gtggacccct tcgtctggaa gaccatcaag     3300

aaccacgaga gccgcaagca cttcctggag ggcttcgact tcctccacta cgacgtcaag     3360

accggggact tcatcctgca cttcaagatg aaccgcaacc tcagtttcca gcgcggcctg     3420

ccggggttca tgcccgcttg ggatatagtc ttcgagaaga atgagacgca gttcgacgcg     3480

aagggcaccc cgttcatcgc cgggaagcgc atcgtgccgg tcatcgagaa ccaccggttc     3540

accgggcgct accgcgacct atacccggcg aacgagttga tcgccctcct ggaggagaag     3600

ggcatcgtgt tccgcgacgg ctccaacatc ctcccgaagc tgctcgaaaa cgacgactcc     3660

cacgccatcg acacgatggt cgcgctgatc cggtcggtgc tccagatgcg gaactccaac     3720

gccgcgacgg gcgaggacta catcaacagt ccggtccgcg atctgaacgg cgtctgcttc     3780

gactcccggt tccagaaccc cgagtggccg atggacgcgg acgcgaacgg cgcataccac     3840

atcgccctaa aagggcaatt gctgctcaac cacctcaagg aatccaaaga cctaaagctc     3900

cagaacggca tctccaacca ggactggctg gcgtacatcc aggaactgcg gaacgggagc     3960

aaaaaacgtc ggatcaagca agattga                                         3987


<210>  35
<211>  3987
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cas12a polynucleotide

<400>  35
atggcgggct ccaagaaacg ccggattaag caagataccc agttcgaggg gttcacgaac       60

ctctaccaag tgagcaagac cctccgattc gaactgattc ctcaggggaa gaccctcaag      120

cacatccagg agcaagggtt catcgaggag gacaaggcgc ggaacgacca ctacaaggaa      180

ctcaaaccca tcatcgaccg catctacaag acctacgccg atcagtgcct ccagctcgtg      240

cagttggact gggagaacct cagcgcggcc attgactcct accggaagga gaaaacggag      300

gagacgcgca acgcgctcat cgaggaacag gcaacctatc gcaacgccat ccacgactac      360

ttcatcggga ggactgacaa cctcactgac gcgattaaca agcgccacgc ggagatatac      420

aagggactct tcaaagcgga gctgtttaac ggcaaggttc tcaagcaact cggcactgtg      480

accacgaccg agcatgagaa cgccctgctc cgctccttcg acaagttcac cacctacttc      540

tccgggttct accgcaaccg caagaatgtc ttcagcgcgg aggacatcag cacggccatt      600

ccacatcgaa tcgtccaaga taacttcccg aagttcaagg agaactgcca catcttcacc      660

cgactcatta ctgctgtacc gtcgttacgc gaacacttcg agaacgtcaa gaaggcaatt      720

ggaatcttcg tctctacgtc aatagaggag gtgttcagct tccctttcta caaccagctc      780

cttacgcaga cccagataga cctgtacaat cagctcctcg gtgggatcag ccgggaggcg      840

gggactgaga agattaaagg gctcaacgag gtcttgaacc tggccatcca aaaaaacgat      900

gagacggcgc acatcatcgc ctcgctgccc caccggttca tcccgctgtt caagcagatc      960

ctcagtgaca ggaacacctt gagctttatc ctagaggagt tcaagagcga cgaggaggtg     1020

atccagagct tctgcaagta caaaaccctg ctgaggaacg agaacgtcct ggagacggcg     1080

gaggcgctgt tcaacgagct gaactctatc gacttaactc acatattcat ctcgcacaag     1140

aagctggaga ctattagctc tgcactctgc gaccactggg acaccctccg caacgcgctc     1200

tacgagcgcc gcatctcgga gctgaccggg aagatcacca aatccgcgaa ggaaaaggtc     1260

cagcgttccc tcaaacacga ggatattaac ttacaggaga ttatctcagc ggctgggaag     1320

gagttgtcag aggcgttcaa gcagaaaact tccgagatcc tgagccacgc gcacgcagcg     1380

ctcgaccagc ctctgcccac caccctcaaa aagcaggaag aaaaagagat cctcaagagc     1440

cagttggact ccctgctggg gctctatcac cttctcgact ggttcgccgt cgatgagtcg     1500

aacgaggtgg accccgagtt ctccgcccgg ctgaccggca tcaagctaga gatggagccg     1560

tccctcagct tctacaataa ggcccgcaac tacgcgacca aaaaacccta cagcgtggag     1620

aagttcaagc tgaacttcca gatgccgacc ttagcacgcg gttgggacgt aaacagggag     1680

aagaacaatg gagccatcct gttcgtcaag aacgggcttt actacctcgg gataatgccc     1740

aagcagaagg gccgctacaa ggccctttcc ttcgagccga cggagaaaac ctccgagggg     1800

ttcgacaaga tgtactacga ctacttcccc gacgccgcca agatgatccc gaagtgctca     1860

acgcagctaa aagccgtgac cgcccacttc cagacccaca cgacgccgat cctgctgagc     1920

aacaacttca tcgagcccct tgagatcact aaggagatat acgacctgaa caaccccgag     1980

aaggagccca agaagtttca aaccgcctac gccaaaaaaa ctggcgacca aaagggctac     2040

agggaggcgc tgtgtaagtg gatcgacttc acacgcgact tcctttcgaa gtatacgaag     2100

acaacctcta ttgacctgag cagcctgcgt cctagctccc agtacaaaga tttgggcgag     2160

tactacgcgg agcttaatcc actactctac cacatctcat tccagcgcat cgctgagaag     2220

gaaatcatgg acgcggtgga gacaggcaaa ctgtacctct tccagatata caacaaagac     2280

ttcgctaagg ggcaccacgg gaagcccaac cttcatacgc tctactggac gggcctattc     2340

agccccgaaa atctggccaa gacctccatc aagctgaacg gccaagcgga gctgttctac     2400

agacccaaga gccggatgaa gcggatggcc cacaggctcg gcgagaaaat gcttaacaaa     2460

aagttgaagg accagaaaac ccctatcccc gacaccctct accaggaact gtacgactac     2520

gtgaaccaca ggctctcgca cgacctttcc gacgaggccc gtgccctact cccgaacgtc     2580

attaccaaag aggtttcgca cgagatcatc aaggaccggc ggttcacgag cgacaagttt     2640

ttctttcacg tccccatcac ccttaactac caggcggcca actccccatc caagttcaac     2700

cagcgtgtga atgcctacct caaggagcac ccagagaccc cgatcattgg gatcgaccgg     2760

ggcgagcgga acctgatcta catcaccgtc atcgactcga cgggcaagat tcttgagcag     2820

agatcgttga ataccataca gcagttcgac taccagaaga aactcgacaa ccgcgagaag     2880

gagcgcgtgg cggcccgcca ggcgtggtcc gtcgttggga cgattaagga cttgaaacaa     2940

ggttatctgt cccaagtcat ccacgagatc gttgatctga tgatccacta tcaggcagtg     3000

gtggtgctgg agaatctcaa cttcggcttc aagagtaagc ggacgggaat cgccgagaag     3060

gccgtgtacc agcagttcga gaagatgctg atcgacaagc tcaactgcct tgtgctgaaa     3120

gactacccgg ccgagaaggt cggcggcgtc ctcaacccgt accaacttac cgaccagttc     3180

acctccttcg ccaagatggg cactcagtcc gggttcttgt tctacgtccc cgcaccttac     3240

acctctaaga tcgaccctct gactggcttc gtagatccat tcgtgtggaa gaccattaag     3300

aaccacgaga gccgcaagca cttcctggag ggcttcgact tcctgcacta cgacgtgaag     3360

accggggact tcatccttca cttcaagatg aaccggaacc tcagcttcca gcggggcctg     3420

ccggggttca tgcccgcctg ggacatcgtg ttcgagaaga acgagaccca gttcgacgcg     3480

aagggcacgc ccttcatcgc cgggaagcgt atcgtgccgg tgatcgagaa ccatcgtttc     3540

acgggtcgct accgtgacct ctacccggcg aacgagctta tcgcactcct ggaggagaag     3600

ggcatcgtct tccgggacgg ctccaacatc ctcccgaaac tgctggaaaa cgacgactct     3660

cacgccatcg acacgatggt ggccctcatc cggtccgtgc tccaaatgcg gaacagcaac     3720

gccgccaccg gtgaggacta catcaacagc ccggtccggg atctgaacgg ggtgtgcttc     3780

gattcgcggt tccagaatcc tgagtggccg atggacgcgg atgcaaacgg ggcgtaccac     3840

atcgcgctca agggccagtt acttctgaac caccttaagg agtctaaaga tttgaaactc     3900

cagaacggga tctcgaacca ggactggctg gcctacatcc aagagttgcg gaacggcagc     3960

aagaagcggc ggattaagca agattag                                         3987


<210>  36
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RNA Spacer


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  wherein n is A, C, T or G

<400>  36
nnnnnnnnnn nnnnnnnnn                                                    19


<210>  37
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Target strand


<220>
<221>  misc_feature
<222>  (4)..(22)
<223>  wherein n is A, C, T or G

<400>  37
aaannnnnnn nnnnnnnnnn nn                                                22


<210>  38
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Non-target strand


<220>
<221>  misc_feature
<222>  (4)..(22)
<223>  wherein n is A, C, T or G

<400>  38
tttnnnnnnn nnnnnnnnnn nn                                                22


<210>  39
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GCN4 sequence

<400>  39

Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
1               5                   10                  15      


Leu Lys Lys Gly Ser Gly Ser Gly 
            20                  


<210>  40
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GCN4 sequence

<400>  40

Glu Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
1               5                   10                  15      


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
            20                  25                  30          


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
        35                  40                  45              


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
    50                  55                  60                  


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
65                  70                  75                  80  


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
                85                  90                  95      


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
            100                 105                 110         


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
        115                 120                 125             


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
    130                 135                 140                 


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
145                 150                 155                 160 


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
                165                 170                 175     


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
            180                 185                 190         


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
        195                 200                 205             


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
    210                 215                 220                 


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
225                 230                 235                 240 


Gly 
    


<210>  41
<211>  277
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ScFv antibody

<400>  41

Met Gly Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala 
            20                  25                  30          


Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys 
        35                  40                  45              


Leu Phe Lys Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala Leu 
                85                  90                  95      


Trp Tyr Ser Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu 
            100                 105                 110         


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ser Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly 
145                 150                 155                 160 


Phe Ser Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp 
            180                 185                 190         


Tyr Asn Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asn Gly 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr 
    210                 215                 220                 


Ala Leu Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser 
        275         


<210>  42
<211>  66
<212>  DNA
<213>  Saccharomyces bayanus

<400>  42
ttcttgtcgt acttatagat cgctacgtta tttcaatttt gaaaatctga gtcctgggag       60

tgcgga                                                                  66


<210>  43
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser 
                85                  90                  95      


Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly 
            100                 105                 110         


Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln 
        115                 120                 125             


Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser 
    130                 135                 140                 


Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys 
145                 150                 155                 160 


Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His 
                165                 170                 175     


Gly Asn Asp Ser Thr Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp 
            180                 185                 190         


Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro 
        195                 200                 205             


Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala 
    210                 215                 220                 


Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu 
                245                 250                 255     


Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly 
            260                 265                 270         


Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu 
        275                 280                 285             


Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn 
    290                 295                 300                 


Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln 
305                 310                 315                 320 


Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu 
                325                 330                 335     


Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro 
            340                 345                 350         


Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val 
        355                 360                 365             


Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala 
    370                 375                 380                 


Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr 
385                 390                 395                 400 


Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln 
                405                 410                 415     


Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe 
            420                 425                 430         


Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe 
        435                 440                 445             


Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala 
    450                 455                 460                 


Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn 
465                 470                 475                 480 


Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp 
                485                 490                 495     


Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu 
            500                 505                 510         


Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu 
        515                 520                 525             


Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys 
    530                 535                 540                 


His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe 
                565                 570                 575     


Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser 
            580                 585                 590         


Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln 
        595                 600                 605             


Asp 
    


<210>  44
<211>  482
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polypeptide

<400>  44

Met Val Arg Ser Gly Asn Lys Ala Ala Trp Leu Cys Met Asp Val Gly 
1               5                   10                  15      


Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe Glu Gln 
            20                  25                  30          


Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe Ala Glu 
        35                  40                  45              


Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly Thr Asp 
    50                  55                  60                  


Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val His Arg 
65                  70                  75                  80  


His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu Ser Lys 
                85                  90                  95      


Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu Ile Val 
            100                 105                 110         


Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe Glu Lys 
        115                 120                 125             


Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser Lys Ser 
    130                 135                 140                 


Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile Ser Glu 
145                 150                 155                 160 


Arg His Ser Ile His Trp Pro Cys Arg Leu Thr Ile Gly Ser Asn Leu 
                165                 170                 175     


Ser Ile Arg Ile Ala Ala Tyr Lys Ser Ile Leu Gln Glu Arg Val Lys 
            180                 185                 190         


Lys Thr Thr Trp Asp Ala Lys Thr Leu Lys Lys Glu Asp Ile Gln Lys 
        195                 200                 205             


Glu Thr Val Tyr Cys Leu Asn Asp Asp Asp Glu Thr Glu Val Leu Lys 
    210                 215                 220                 


Glu Asp Ile Ile Gln Gly Phe Arg Tyr Gly Ser Asp Ile Val Pro Phe 
225                 230                 235                 240 


Ser Lys Val Asp Glu Glu Gln Met Lys Tyr Lys Ser Glu Gly Lys Cys 
                245                 250                 255     


Phe Ser Val Leu Gly Phe Cys Lys Ser Ser Gln Val Gln Arg Arg Phe 
            260                 265                 270         


Phe Met Gly Asn Gln Val Leu Lys Val Phe Ala Ala Arg Asp Asp Glu 
        275                 280                 285             


Ala Ala Ala Val Ala Leu Ser Ser Leu Ile His Ala Leu Asp Asp Leu 
    290                 295                 300                 


Asp Ile Trp Ala Ile Val Arg Tyr Ala Tyr Asp Lys Arg Ala Asn Pro 
305                 310                 315                 320 


Gln Val Gly Val Ala Phe Pro His Ile Lys His Asn Tyr Glu Cys Leu 
                325                 330                 335     


Val Tyr Val Gln Leu Pro Phe Met Glu Asp Leu Arg Gln Tyr Met Phe 
            340                 345                 350         


Ser Ser Leu Lys Asn Ser Lys Lys Tyr Ala Pro Thr Glu Ala Gln Leu 
        355                 360                 365             


Asn Ala Val Asp Ala Leu Ile Asp Ser Met Ser Leu Ala Lys Lys Asp 
    370                 375                 380                 


Glu Lys Thr Asp Thr Leu Glu Asp Leu Phe Pro Thr Thr Lys Ile Pro 
385                 390                 395                 400 


Asn Pro Arg Phe Gln Arg Leu Phe Gln Cys Leu Leu His Arg Ala Leu 
                405                 410                 415     


His Pro Arg Glu Pro Leu Pro Pro Ile Gln Gln His Ile Trp Asn Met 
            420                 425                 430         


Leu Asn Pro Pro Ala Glu Val Thr Thr Lys Ser Gln Ile Pro Leu Ser 
        435                 440                 445             


Lys Ile Lys Thr Leu Phe Pro Leu Ile Glu Ala Lys Lys Lys Asp Gln 
    450                 455                 460                 


Val Thr Ala Gln Glu Ile Phe Gln Asp Asn His Glu Asp Gly Pro Thr 
465                 470                 475                 480 


Ala Lys 
        


<210>  45
<211>  10
<212>  DNA
<213>  Methanobacterium thermoautotrophicum

<400>  45
aatttttgga                                                              10


<210>  46
<211>  83
<212>  PRT
<213>  Methanobacterium thermoautotrophicum

<400>  46

Gly Ser Val Ile Asp Val Ser Ser Gln Arg Val Asn Val Gln Arg Pro 
1               5                   10                  15      


Leu Asp Ala Leu Gly Asn Ser Leu Asn Ser Pro Val Ile Ile Lys Leu 
            20                  25                  30          


Lys Gly Asp Arg Glu Phe Arg Gly Val Leu Lys Ser Phe Asp Leu His 
        35                  40                  45              


Met Asn Leu Val Leu Asn Asp Ala Glu Glu Leu Glu Asp Gly Glu Val 
    50                  55                  60                  


Thr Arg Arg Leu Gly Thr Val Leu Ile Arg Gly Asp Asn Ile Val Tyr 
65                  70                  75                  80  


Ile Ser Pro 
            


<210>  47
<211>  25
<212>  DNA
<213>  Bacteriophage MS2

<400>  47
gcgcacatga ggatcaccca tgtgc                                             25


<210>  48
<211>  116
<212>  PRT
<213>  Bacteriophage MS2

<400>  48

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val 
        35                  40                  45              


Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val 
    50                  55                  60                  


Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro 
65                  70                  75                  80  


Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln 
                85                  90                  95      


Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn 
            100                 105                 110         


Ser Gly Ile Tyr 
        115     


<210>  49
<211>  26
<212>  DNA
<213>  Bacteriophage PP7

<400>  49
ataaggagtt tatatggaaa ccctta                                            26


<210>  50
<211>  127
<212>  PRT
<213>  Bacteriophage PP7

<400>  50

Met Ser Lys Thr Ile Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu 
1               5                   10                  15      


Thr Glu Ile Gln Ser Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val 
            20                  25                  30          


Gly Pro Leu Val Gly Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn 
        35                  40                  45              


Gly Ala Lys Thr Ala Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp 
    50                  55                  60                  


Trp Asp Cys Ser Thr Ser Val Cys Gly Glu Leu Pro Lys Val Arg Tyr 
65                  70                  75                  80  


Thr Gln Val Trp Ser His Asp Val Thr Ile Val Ala Asn Ser Thr Glu 
                85                  90                  95      


Ala Ser Arg Lys Ser Leu Tyr Asp Leu Thr Lys Ser Leu Val Ala Thr 
            100                 105                 110         


Ser Gln Val Glu Asp Leu Val Val Asn Leu Val Pro Leu Gly Arg 
        115                 120                 125         


<210>  51
<211>  19
<212>  DNA
<213>  Shigella flexneri

<400>  51
ctgaatgcct gcgagcatc                                                    19


<210>  52
<211>  62
<212>  PRT
<213>  Shigella phage

<400>  52

Met Lys Ser Ile Arg Cys Lys Asn Cys Asn Lys Leu Leu Phe Lys Ala 
1               5                   10                  15      


Asp Ser Phe Asp His Ile Glu Ile Arg Cys Pro Arg Cys Lys Arg His 
            20                  25                  30          


Ile Ile Met Leu Asn Ala Cys Glu His Pro Thr Glu Lys His Cys Gly 
        35                  40                  45              


Lys Arg Glu Lys Ile Thr His Ser Asp Glu Thr Val Arg Tyr 
    50                  55                  60          


<210>  53
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic BbaJ23119 promoter to drive transcription / translation
       in gram negative bacteria

<400>  53
ttgacagcta gctcagtcct aggtataatg ctagc                                  35


<210>  54
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic BbaJ23102 promoter to drive transcription / translation
       in gram negative bacteria

<400>  54
ttgacagcta gctcagtcct aggtactgtg ctagcgctag caaagaggag aaa              53


<210>  55
<211>  36
<212>  DNA
<213>  Lachnospiraceae bacterium ND2006

<400>  55
gtttcaaaga ttaaataatt tctactaagt gtagat                                 36


<210>  56
<211>  21
<212>  DNA
<213>  Lachnospiraceae bacterium ND2006

<400>  56
taatttctac taagtgtaga t                                                 21


<210>  57
<211>  48
<212>  DNA
<213>  Phage T7

<400>  57
ctagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttg                    48


<210>  58
<211>  532
<212>  DNA
<213>  Agrobacterium tumefaciens

<400>  58
ggagactcga ccagggtaat cagcacgtct gttcggcgcg cctatagcta tggtttctcg       60

caatcgcttt gggcagtcgg ttgtggcggt gcgtcttctg agacccgaag gttggcgatt      120

atctgctgga ggtcttcgat accgtcttcg aagaacaaga catatgttcg ctgagctcgg      180

acataggata gtcggcatag gcggataccc tcgccacgca aatggcgcga tcgacaccct      240

gatcggagcc tgcgaagtgc cacagtttat tggaaccatc ccccgttcat tccgccctgg      300

aatttcactt cgacggcatt ctagatcctc gccgttgtct tagagagcca tctttcgtcg      360

gcgcaccctt aagtgcatgg aaagccgttt tcgcttcaaa tgaaatcgaa aagaagaaaa      420

caaaaatcct agagtaaccg accctcccga taatcgtgaa catcagatga cagcatttct      480

tccgaccgaa gtggctgtgt tggttatgag cttggggaga tggggaggta cc              532


<210>  59
<211>  23
<212>  DNA
<213>  Saccharomyces cereviciae

<400>  59
tttactaaaa acacatgtgg ata                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Saccharomyces cereviciae

<400>  60
gcggcttaac tgtgccctcc atg                                               23


<210>  61
<211>  23
<212>  DNA
<213>  Nicotiana benthamiana

<400>  61
tgccgttaat ttgagagtcc aag                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Nicotiana benthamiana

<400>  62
agttcccaac gaagacctcg agc                                               23


<210>  63
<211>  23
<212>  DNA
<213>  Arabidopsis thaliana

<400>  63
tatgtcaatg gccgtcgaca tgt                                               23


<210>  64
<211>  23
<212>  DNA
<213>  Arabidopsis thaliana

<400>  64
gtgggttgtt tggaagacat gtc                                               23


<210>  65
<211>  5187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Lachnospiraceae bacterium ND2006 (Cas12a), Agrobacterium 
       tumefaciens (VirD2) fusion

<400>  65
atgagcggct ccaagaagcg ccgcatcaag caagattcaa agctggagaa gttcaccaac       60

tgctactcgc tgagcaagac gctgcggttc aaggccatcc ccgtgggcaa gacccaggag      120

aacatcgaca acaagcgcct cctggtcgag gacgagaagc gcgccgagga ctacaagggc      180

gtcaagaagc tcctggaccg gtattacctc agcttcatca acgacgtgct gcactcgatc      240

aagctcaaga acctgaacaa ctacatcagc ctgttccgca agaaaacgcg caccgagaag      300

gagaacaaag agctggagaa cctggagatc aacctgcgga aggagattgc gaaagctttc      360

aagggcaacg agggctacaa gtcgctcttc aagaaagaca taatcgagac catcctgccg      420

gagttcctgg acgacaagga cgagatcgcg ctcgtcaact cgttcaacgg gttcactacg      480

gccttcacgg gtttcttcga taaccgggag aatatgttta gcgaggaggc caagtccacc      540

tccattgcgt tccgctgcat caacgagaac ctgacccgct acatcagcaa catggacatc      600

ttcgagaagg tggacgccat cttcgacaag cacgaggtcc aggagatcaa ggagaagatt      660

ctgaactcgg actacgacgt ggaagacttc ttcgagggcg agtttttcaa cttcgtcctg      720

acccaggagg ggatcgacgt ttataacgcc atcatcggcg ggttcgtcac ggagtcgggc      780

gaaaagatca agggcctgaa cgagtatatt aacctgtaca accagaagac aaagcagaag      840

ctgccgaagt tcaagccgct gtacaagcaa gtcctgtccg accgcgagtc gctgtcgttc      900

tacggcgaag gctacacctc ggacgaggag gtgctggagg tgttccgcaa caccctgaac      960

aagaatagcg aaatttttag ctccattaag aagctcgaga agctgttcaa gaacttcgac     1020

gagtacagca gcgccgggat cttcgtcaag aacggccccg cgatcagcac catctcgaag     1080

gacatcttcg gcgagtggaa cgtcatccgg gacaagtgga acgccgagta cgacgacatt     1140

caccttaaaa agaaggctgt tgtgacggag aagtacgagg acgaccggcg caagtcgttc     1200

aaaaagatcg gctccttctc cctggagcag ctccaggagt acgccgacgc cgacctctcg     1260

gtcgtcgaga agctcaagga gatcatcatt cagaaggtgg acgaaattta caaagtgtac     1320

ggctccagcg agaagctgtt cgacgccgac ttcgtgctgg aaaagtcgct caagaaaaac     1380

gacgccgtgg tggccatcat gaaggacttg ctggacagcg tgaagtcgtt cgagaactac     1440

attaaggcgt tctttggcga gggcaaggag accaaccgcg acgagtcgtt ctacggcgac     1500

ttcgtgctcg cgtacgacat cctgctcaag gtggatcaca tctacgacgc gatccgcaac     1560

tacgtcacgc agaagccgta ctcgaaggac aagttcaagc tgtacttcca gaacccgcag     1620

ttcatgggcg ggtgggacaa ggacaaggaa acggactacc gcgcgaccat cctgcggtac     1680

ggcagcaagt attatctggc gatcatggac aaaaaatatg ccaagtgcct ccagaaaatc     1740

gacaaggacg acgtgaacgg caactacgag aagattaatt acaagctgct ccccggcccc     1800

aacaagatgc tcccgaaggt gttctttagc aagaagtgga tggcctacta caacccgagc     1860

gaggacatcc agaagatcta taagaatggc accttcaaga agggagacat gtttaacctc     1920

aacgactgcc acaagctgat tgacttcttc aaggactcga tctcgcgcta cccgaagtgg     1980

tcgaacgcct acgacttcaa cttcagcgaa acggagaaat acaaagacat cgcgggcttc     2040

taccgcgagg tcgaggagca aggctacaag gtcagcttcg agtccgccag caagaaggag     2100

gtggacaagc tggtggagga gggcaagctc tacatgtttc agatctacaa caaggatttt     2160

agcgacaagt cgcacggcac gccgaacctg cacacgatgt acttcaagct gctgttcgac     2220

gagaacaacc acggccagat ccggctgtcg ggcggtgcgg agctgttcat gcgccgggcg     2280

tcgctcaaga aggaagagct ggtcgtccac ccggccaaca gccccatcgc caacaagaac     2340

cccgacaacc ccaagaaaac gacgacactc agctatgatg tctataaaga caagcgcttc     2400

tcggaggacc agtacgagct gcacatcccc atcgccatca acaagtgccc caagaacatc     2460

ttcaagatca acacggaggt ccgcgtgctc ctcaagcacg acgacaaccc gtacgtcatc     2520

ggcatcgacc ggggcgagcg caacctgctg tacatcgtcg tcgtcgatgg caagggcaac     2580

atcgtggagc agtattccct gaacgagatc atcaacaact tcaacggcat ccgcatcaag     2640

accgactacc actccctcct cgacaagaag gagaaagagc gcttcgaggc ccgccagaac     2700

tggacctcca tcgagaacat caaggagctt aaggcgggct acatctccca agtcgtccac     2760

aagatctgcg agctggtcga gaagtacgac gcggtgatcg ccctggaaga cctgaactcc     2820

ggcttcaaga actcccgcgt aaaggtggag aagcaagtgt accagaagtt cgagaagatg     2880

ctgatcgaca agctgaacta catggtggac aagaaatcga acccgtgcgc gaccggcggc     2940

gcgctcaagg gctaccagat cacgaacaag ttcgagtcgt tcaagtccat gagcacgcag     3000

aacggcttta tcttctacat cccggcctgg ctgacgtcga agatcgaccc ctcgaccggc     3060

ttcgtgaacc tgctcaagac caagtatact agcattgccg actccaagaa attcatctcg     3120

tccttcgacc gcatcatgta cgtcccggag gaggaccttt ttgagttcgc cctcgactac     3180

aagaacttca gccgcaccga cgccgactac atcaagaagt ggaagctgta ctcgtacggg     3240

aaccgcatcc gtatttttcg caacccgaag aaaaataatg tcttcgactg ggaggaggtg     3300

tgcctgacca gcgcctacaa ggagctgttc aacaagtacg gcatcaacta ccaacagggc     3360

gacatccggg cccttctctg cgagcagagc gacaaggcgt tctactcgtc gttcatggcc     3420

ctgatgagcc tgatgctcca gatgaggaac agcatcaccg gccgcaccga cgtggacttc     3480

ctcatcagcc ccgtcaagaa ctcggacggc atattttatg actcgcggaa ctacgaggcc     3540

caggagaacg ccatcctgcc caagaacgcc gacgccaacg gcgcgtacaa catcgcccgc     3600

aaggtgctct gggccatcgg ccagttcaag aaggcggaag acgagaagct ggacaaggtg     3660

aagatcgcca tctccaacaa ggagtggctg gagtacgcgc agacgtccgt caagcacggc     3720

tccaagaaac ggcggatcaa acaagattcc ggtggaagtt ccggaggttc aagcgggtct     3780

gaaacgccgg gcaccagcga gtcggcgacc ccggaaagca gcggtggttc ttccggcggt     3840

agcatgcccg atcgagctca agttatcatt cgcattgtgc cgggaggtgg caccaagacc     3900

cttcaacaaa ttatcaatca gttggagtat ctatcccgga agggcaggct ggagctgcag     3960

cgttcagccc gacatctcga tattcccctg ccaccggatc aaatccacga acttgcccga     4020

agctgggttc aagagactgg aacttatgac gaaagtcagc cagacgagga aaggcaacag     4080

gagttgacca cccatattat tgtaagcttc cccgccggta caagccaggt agcggcttat     4140

gcggcgagcc gggagtgggc agccgagatg tttgggtcag gcgcaggggg gggccgatac     4200

aactatctta cggccttcca catcgatcgc gaccacccac atctgcatgt cgtcgtcaat     4260

cggcgcgaac ttttaggaca cggctggctg aagatatctc ggcgccatcc ccaactgaat     4320

tacgacgccc tgcgcataaa gatggccgag atttcacttc gtcatggcat tgccctcgat     4380

gcgagccgac gagcagaacg tggcatcacc gagcggccga tcacttatgc ccaatatcgg     4440

cgccttgagc gggagcaggc tcgccaaatc cgtttcgaag acgcggattt ggaacagtcg     4500

tcgccgcaag gagatcatcc agaattcagc caacctttcg atacatcccc atttgaagca     4560

tccgcgggcg gaccggagga catgcctcgg cccaacaatc ggcagaatga gtcgcaagtt     4620

catctccagg agccagctgg tgtcagcaac gaagccggtg tccttgtgcg ggttgcattg     4680

gaaacggagc gccttgctca accattcgtt tccgaaacca ttctcgcgga cgacataggg     4740

agcggctctt cgcgtgttgc cgagggccgt gtggagagcg caaaccgcac tcccgatatt     4800

cctcgcgcag caactgaagc tgccacgcac acgacacacg accggcagcg gcgtgcaaag     4860

cgtcctcatg atgacgacgg agggccgagt ggagcaaaac gtgtgacatt ggaaggcatc     4920

gcggttgggc cccaggcgaa cgccggcgaa caggatggca gtagtggccc cttagtacgg     4980

caagctggaa cgtcacggcc atctccaccg acggccacga cgcgggccag caccgcaacc     5040

gattcattgt ctgctacagc ccacctccag caacggagag gtgtcctttc aaagcgtccg     5100

cgtgaagatg atgatggaga accgagtgaa cgcaaacgcg agagagatga gcgcagcaag     5160

gacgggcgtg ggggaaatag gagatag                                         5187


<210>  66
<211>  1728
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Lachnospiraceae bacterium ND2006 (Cas12a), Agrobacterium 
       tumefaciens (VirD2) fusion

<400>  66

Met Ser Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Ser Lys Leu Glu 
1               5                   10                  15      


Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala 
            20                  25                  30          


Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu 
        35                  40                  45              


Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu 
    50                  55                  60                  


Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile 
65                  70                  75                  80  


Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr 
                85                  90                  95      


Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu 
            100                 105                 110         


Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser 
        115                 120                 125             


Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp 
    130                 135                 140                 


Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr 
145                 150                 155                 160 


Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu 
                165                 170                 175     


Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr 
            180                 185                 190         


Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe 
        195                 200                 205             


Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp 
    210                 215                 220                 


Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu 
225                 230                 235                 240 


Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val 
                245                 250                 255     


Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu 
            260                 265                 270         


Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr 
        275                 280                 285             


Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly 
    290                 295                 300                 


Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn 
305                 310                 315                 320 


Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe 
                325                 330                 335     


Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly 
            340                 345                 350         


Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val 
        355                 360                 365             


Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys 
    370                 375                 380                 


Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe 
385                 390                 395                 400 


Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp 
                405                 410                 415     


Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys 
            420                 425                 430         


Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp 
        435                 440                 445             


Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val 
    450                 455                 460                 


Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr 
465                 470                 475                 480 


Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser 
                485                 490                 495     


Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp 
            500                 505                 510         


His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser 
        515                 520                 525             


Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly 
    530                 535                 540                 


Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr 
545                 550                 555                 560 


Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys 
                565                 570                 575     


Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile 
            580                 585                 590         


Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe 
        595                 600                 605             


Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln 
    610                 615                 620                 


Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu 
625                 630                 635                 640 


Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg 
                645                 650                 655     


Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu 
            660                 665                 670         


Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly 
        675                 680                 685             


Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu 
    690                 695                 700                 


Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe 
705                 710                 715                 720 


Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys 
                725                 730                 735     


Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg Leu Ser Gly Gly 
            740                 745                 750         


Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu Val 
        755                 760                 765             


Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn Pro 
    770                 775                 780                 


Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr Lys Asp Lys Arg Phe 
785                 790                 795                 800 


Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile Ala Ile Asn Lys Cys 
                805                 810                 815     


Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val Arg Val Leu Leu Lys 
            820                 825                 830         


His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn 
        835                 840                 845             


Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly Asn Ile Val Glu Gln 
    850                 855                 860                 


Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn Gly Ile Arg Ile Lys 
865                 870                 875                 880 


Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe Glu 
                885                 890                 895     


Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile Lys Glu Leu Lys Ala 
            900                 905                 910         


Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys Glu Leu Val Glu Lys 
        915                 920                 925             


Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn Ser Gly Phe Lys Asn 
    930                 935                 940                 


Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
945                 950                 955                 960 


Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys Lys Ser Asn Pro Cys 
                965                 970                 975     


Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile Thr Asn Lys Phe Glu 
            980                 985                 990         


Ser Phe Lys Ser Met Ser Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro 
        995                 1000                 1005             


Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn 
    1010                 1015                 1020             


Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe 
    1025                 1030                 1035             


Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu 
    1040                 1045                 1050             


Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala 
    1055                 1060                 1065             


Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile 
    1070                 1075                 1080             


Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu 
    1085                 1090                 1095             


Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr 
    1100                 1105                 1110             


Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu 
    1115                 1120                 1125             


Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser 
    1130                 1135                 1140             


Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr Gly Arg  Thr Asp Val 
    1145                 1150                 1155             


Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr 
    1160                 1165                 1170             


Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys 
    1175                 1180                 1185             


Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu 
    1190                 1195                 1200             


Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp 
    1205                 1210                 1215             


Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala 
    1220                 1225                 1230             


Gln Thr  Ser Val Lys His Gly  Ser Lys Lys Arg Arg  Ile Lys Gln 
    1235                 1240                 1245             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1250                 1255                 1260             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1265                 1270                 1275             


Gly Gly  Ser Met Pro Asp Arg  Ala Gln Val Ile Ile  Arg Ile Val 
    1280                 1285                 1290             


Pro Gly  Gly Gly Thr Lys Thr  Leu Gln Gln Ile Ile  Asn Gln Leu 
    1295                 1300                 1305             


Glu Tyr  Leu Ser Arg Lys Gly  Arg Leu Glu Leu Gln  Arg Ser Ala 
    1310                 1315                 1320             


Arg His  Leu Asp Ile Pro Leu  Pro Pro Asp Gln Ile  His Glu Leu 
    1325                 1330                 1335             


Ala Arg  Ser Trp Val Gln Glu  Thr Gly Thr Tyr Asp  Glu Ser Gln 
    1340                 1345                 1350             


Pro Asp  Glu Glu Arg Gln Gln  Glu Leu Thr Thr His  Ile Ile Val 
    1355                 1360                 1365             


Ser Phe  Pro Ala Gly Thr Ser  Gln Val Ala Ala Tyr  Ala Ala Ser 
    1370                 1375                 1380             


Arg Glu  Trp Ala Ala Glu Met  Phe Gly Ser Gly Ala  Gly Gly Gly 
    1385                 1390                 1395             


Arg Tyr  Asn Tyr Leu Thr Ala  Phe His Ile Asp Arg  Asp His Pro 
    1400                 1405                 1410             


His Leu  His Val Val Val Asn  Arg Arg Glu Leu Leu  Gly His Gly 
    1415                 1420                 1425             


Trp Leu  Lys Ile Ser Arg Arg  His Pro Gln Leu Asn  Tyr Asp Ala 
    1430                 1435                 1440             


Leu Arg  Ile Lys Met Ala Glu  Ile Ser Leu Arg His  Gly Ile Ala 
    1445                 1450                 1455             


Leu Asp  Ala Ser Arg Arg Ala  Glu Arg Gly Ile Thr  Glu Arg Pro 
    1460                 1465                 1470             


Ile Thr  Tyr Ala Gln Tyr Arg  Arg Leu Glu Arg Glu  Gln Ala Arg 
    1475                 1480                 1485             


Gln Ile  Arg Phe Glu Asp Ala  Asp Leu Glu Gln Ser  Ser Pro Gln 
    1490                 1495                 1500             


Gly Asp  His Pro Glu Phe Ser  Gln Pro Phe Asp Thr  Ser Pro Phe 
    1505                 1510                 1515             


Glu Ala  Ser Ala Gly Gly Pro  Glu Asp Met Pro Arg  Pro Asn Asn 
    1520                 1525                 1530             


Arg Gln  Asn Glu Ser Gln Val  His Leu Gln Glu Pro  Ala Gly Val 
    1535                 1540                 1545             


Ser Asn  Glu Ala Gly Val Leu  Val Arg Val Ala Leu  Glu Thr Glu 
    1550                 1555                 1560             


Arg Leu  Ala Gln Pro Phe Val  Ser Glu Thr Ile Leu  Ala Asp Asp 
    1565                 1570                 1575             


Ile Gly  Ser Gly Ser Ser Arg  Val Ala Glu Gly Arg  Val Glu Ser 
    1580                 1585                 1590             


Ala Asn  Arg Thr Pro Asp Ile  Pro Arg Ala Ala Thr  Glu Ala Ala 
    1595                 1600                 1605             


Thr His  Thr Thr His Asp Arg  Gln Arg Arg Ala Lys  Arg Pro His 
    1610                 1615                 1620             


Asp Asp  Asp Gly Gly Pro Ser  Gly Ala Lys Arg Val  Thr Leu Glu 
    1625                 1630                 1635             


Gly Ile  Ala Val Gly Pro Gln  Ala Asn Ala Gly Glu  Gln Asp Gly 
    1640                 1645                 1650             


Ser Ser  Gly Pro Leu Val Arg  Gln Ala Gly Thr Ser  Arg Pro Ser 
    1655                 1660                 1665             


Pro Pro  Thr Ala Thr Thr Arg  Ala Ser Thr Ala Thr  Asp Ser Leu 
    1670                 1675                 1680             


Ser Ala  Thr Ala His Leu Gln  Gln Arg Arg Gly Val  Leu Ser Lys 
    1685                 1690                 1695             


Arg Pro  Arg Glu Asp Asp Asp  Gly Glu Pro Ser Glu  Arg Lys Arg 
    1700                 1705                 1710             


Glu Arg  Asp Glu Arg Ser Lys  Asp Gly Arg Gly Gly  Asn Arg Arg 
    1715                 1720                 1725             


<210>  67
<211>  636
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Agrobacterium tumefaciens, Bacteriophage MS2 (MCP) fusion

<400>  67
atgagcgggt ccaagaagcg ccgcatcaag caggacgcca gcaatttcac tcaattcgtc       60

ctggtcgaca acggcggtac gggtgatgtc accgtagccc cctcgaattt tgccaatgga      120

gtggcggaat ggatctccag caactcgcgg tcccaagcgt ataaagtgac ctgctccgtc      180

cgccagtcat cggcccagaa gcggaagtac accatcaagg tcgaggttcc caaagttgcg      240

acgcagaccg tgggcggcgt tgaactgccg gtggcggcct ggcgcagcta cctgaacatg      300

gaactcacca tcccgatatt cgcaacgaac tccgactgcg aattgatcgt caaggcgatg      360

cagggcctcc tcaaggatgg aaatccgatc ccgtccgcta ttgccgcgaa ctccggcatt      420

tattctgctg gtagcaagaa gcgtcggatc aaacaggatt cgggcggcag cagtggtggc      480

tcttcggcca gcctcgccag aggcggccct aacgcagtgg gccttctgac gacaaacgaa      540

tccttcgaga aaaatatcaa tgaggtctat aaccgcaccc gagcggagct ggatgcctca      600

tcgcgtgacc gctcgcgcag cgggctttcg aggtaa                                636


<210>  68
<211>  211
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Agrobacterium tumefaciens, Bacteriophage MS2 (MCP) fusion

<400>  68

Met Ser Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Ala Ser Asn Phe 
1               5                   10                  15      


Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly Asp Val Thr Val 
            20                  25                  30          


Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu Trp Ile Ser Ser Asn 
        35                  40                  45              


Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val Arg Gln Ser Ser 
    50                  55                  60                  


Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu Val Pro Lys Val Ala 
65                  70                  75                  80  


Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val Ala Ala Trp Arg Ser 
                85                  90                  95      


Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala Thr Asn Ser Asp 
            100                 105                 110         


Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu Lys Asp Gly Asn 
        115                 120                 125             


Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile Tyr Ser Ala Gly 
    130                 135                 140                 


Ser Lys Lys Arg Arg Ile Lys Gln Asp Ser Gly Gly Ser Ser Gly Gly 
145                 150                 155                 160 


Ser Ser Ala Ser Leu Ala Arg Gly Gly Pro Asn Ala Val Gly Leu Leu 
                165                 170                 175     


Thr Thr Asn Glu Ser Phe Glu Lys Asn Ile Asn Glu Val Tyr Asn Arg 
            180                 185                 190         


Thr Arg Ala Glu Leu Asp Ala Ser Ser Arg Asp Arg Ser Arg Ser Gly 
        195                 200                 205             


Leu Ser Arg 
    210     


<210>  69
<211>  5289
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Lachnospiraceae bacterium ND2006 (Cas12a), Agrobacterium 
       tumefaciens fusion

<400>  69
atgcccgatc gagctcaagt tatcattcgc attgtgccgg gaggtggcac caagaccctt       60

caacaaatta tcaatcagtt ggagtatcta tcccggaagg gcaggctgga gctgcagcgt      120

tcagcccgac atctcgatat tcccctgcca ccggatcaaa tccacgaact tgcccgaagc      180

tgggttcaag agactggaac ttatgacgaa agtcagccag acgaggaaag gcaacaggag      240

ttgaccaccc atattattgt aagcttcccc gccggtacaa gccaggtagc ggcttatgcg      300

gcgagccggg agtgggcagc cgagatgttt gggtcaggcg cagggggggg ccgatacaac      360

tatcttacgg ccttccacat cgatcgcgac cacccacatc tgcatgtcgt cgtcaatcgg      420

cgcgaacttt taggacacgg ctggctgaag atatctcggc gccatcccca actgaattac      480

gacgccctgc gcataaagat ggccgagatt tcacttcgtc atggcattgc cctcgatgcg      540

agccgacgag cagaacgtgg catcaccgag cggccgatca cttatgccca atatcggcgc      600

cttgagcggg agcaggctcg ccaaatccgt ttcgaagacg cggatttgga acagtcgtcg      660

ccgcaaggag atcatccaga attcagccaa cctttcgata catccccatt tgaagcatcc      720

gcgggcggac cggaggacat gcctcggccc aacaatcggc agaatgagtc gcaagttcat      780

ctccaggagc cagctggtgt cagcaacgaa gccggtgtcc ttgtgcgggt tgcattggaa      840

acggagcgcc ttgctcaacc attcgtttcc gaaaccattc tcgcggacga catagggagc      900

ggctcttcgc gtgttgccga gggccgtgtg gagagcgcaa accgcactcc cgatattcct      960

cgcgcagcaa ctgaagctgc cacgcacacg acacacgacc ggcagcggcg tgcaaagcgt     1020

cctcatgatg acgacggagg gccgagtgga gcaaaacgtg tgacattgga aggcatcgcg     1080

gttgggcccc aggcgaacgc cggcgaacag gatggcagta gtggcccctt agtacggcaa     1140

gctggaacgt cacggccatc tccaccgacg gccacgacgc gggccagcac cgcaaccgat     1200

tcattgtctg ctacagccca cctccagcaa cggagaggtg tcctttcaaa gcgtccgcgt     1260

gaagatgatg atggagaacc gagtgaacgc aaacgcgaga gagatgagcg cagcaaggac     1320

gggcgtgggg gaaataggag aagcggtggc tcctcgggtg gcagcatgag cggctccaag     1380

aagcgccgca tcaagcaaga ttcaaagctg gagaagttca ccaactgcta ctcgctgagc     1440

aagacgctgc ggttcaaggc catccccgtg ggcaagaccc aggagaacat cgacaacaag     1500

cgcctcctgg tcgaggacga gaagcgcgcc gaggactaca agggcgtcaa gaagctcctg     1560

gaccggtatt acctcagctt catcaacgac gtgctgcact cgatcaagct caagaacctg     1620

aacaactaca tcagcctgtt ccgcaagaaa acgcgcaccg agaaggagaa caaagagctg     1680

gagaacctgg agatcaacct gcggaaggag attgcgaaag ctttcaaggg caacgagggc     1740

tacaagtcgc tcttcaagaa agacataatc gagaccatcc tgccggagtt cctggacgac     1800

aaggacgaga tcgcgctcgt caactcgttc aacgggttca ctacggcctt cacgggtttc     1860

ttcgataacc gggagaatat gtttagcgag gaggccaagt ccacctccat tgcgttccgc     1920

tgcatcaacg agaacctgac ccgctacatc agcaacatgg acatcttcga gaaggtggac     1980

gccatcttcg acaagcacga ggtccaggag atcaaggaga agattctgaa ctcggactac     2040

gacgtggaag acttcttcga gggcgagttt ttcaacttcg tcctgaccca ggaggggatc     2100

gacgtttata acgccatcat cggcgggttc gtcacggagt cgggcgaaaa gatcaagggc     2160

ctgaacgagt atattaacct gtacaaccag aagacaaagc agaagctgcc gaagttcaag     2220

ccgctgtaca agcaagtcct gtccgaccgc gagtcgctgt cgttctacgg cgaaggctac     2280

acctcggacg aggaggtgct ggaggtgttc cgcaacaccc tgaacaagaa tagcgaaatt     2340

tttagctcca ttaagaagct cgagaagctg ttcaagaact tcgacgagta cagcagcgcc     2400

gggatcttcg tcaagaacgg ccccgcgatc agcaccatct cgaaggacat cttcggcgag     2460

tggaacgtca tccgggacaa gtggaacgcc gagtacgacg acattcacct taaaaagaag     2520

gctgttgtga cggagaagta cgaggacgac cggcgcaagt cgttcaaaaa gatcggctcc     2580

ttctccctgg agcagctcca ggagtacgcc gacgccgacc tctcggtcgt cgagaagctc     2640

aaggagatca tcattcagaa ggtggacgaa atttacaaag tgtacggctc cagcgagaag     2700

ctgttcgacg ccgacttcgt gctggaaaag tcgctcaaga aaaacgacgc cgtggtggcc     2760

atcatgaagg acttgctgga cagcgtgaag tcgttcgaga actacattaa ggcgttcttt     2820

ggcgagggca aggagaccaa ccgcgacgag tcgttctacg gcgacttcgt gctcgcgtac     2880

gacatcctgc tcaaggtgga tcacatctac gacgcgatcc gcaactacgt cacgcagaag     2940

ccgtactcga aggacaagtt caagctgtac ttccagaacc cgcagttcat gggcgggtgg     3000

gacaaggaca aggaaacgga ctaccgcgcg accatcctgc ggtacggcag caagtattat     3060

ctggcgatca tggacaaaaa atatgccaag tgcctccaga aaatcgacaa ggacgacgtg     3120

aacggcaact acgagaagat taattacaag ctgctccccg gccccaacaa gatgctcccg     3180

aaggtgttct ttagcaagaa gtggatggcc tactacaacc cgagcgagga catccagaag     3240

atctataaga atggcacctt caagaaggga gacatgttta acctcaacga ctgccacaag     3300

ctgattgact tcttcaagga ctcgatctcg cgctacccga agtggtcgaa cgcctacgac     3360

ttcaacttca gcgaaacgga gaaatacaaa gacatcgcgg gcttctaccg cgaggtcgag     3420

gagcaaggct acaaggtcag cttcgagtcc gccagcaaga aggaggtgga caagctggtg     3480

gaggagggca agctctacat gtttcagatc tacaacaagg attttagcga caagtcgcac     3540

ggcacgccga acctgcacac gatgtacttc aagctgctgt tcgacgagaa caaccacggc     3600

cagatccggc tgtcgggcgg tgcggagctg ttcatgcgcc gggcgtcgct caagaaggaa     3660

gagctggtcg tccacccggc caacagcccc atcgccaaca agaaccccga caaccccaag     3720

aaaacgacga cactcagcta tgatgtctat aaagacaagc gcttctcgga ggaccagtac     3780

gagctgcaca tccccatcgc catcaacaag tgccccaaga acatcttcaa gatcaacacg     3840

gaggtccgcg tgctcctcaa gcacgacgac aacccgtacg tcatcggcat cgaccggggc     3900

gagcgcaacc tgctgtacat cgtcgtcgtc gatggcaagg gcaacatcgt ggagcagtat     3960

tccctgaacg agatcatcaa caacttcaac ggcatccgca tcaagaccga ctaccactcc     4020

ctcctcgaca agaaggagaa agagcgcttc gaggcccgcc agaactggac ctccatcgag     4080

aacatcaagg agcttaaggc gggctacatc tcccaagtcg tccacaagat ctgcgagctg     4140

gtcgagaagt acgacgcggt gatcgccctg gaagacctga actccggctt caagaactcc     4200

cgcgtaaagg tggagaagca agtgtaccag aagttcgaga agatgctgat cgacaagctg     4260

aactacatgg tggacaagaa atcgaacccg tgcgcgaccg gcggcgcgct caagggctac     4320

cagatcacga acaagttcga gtcgttcaag tccatgagca cgcagaacgg ctttatcttc     4380

tacatcccgg cctggctgac gtcgaagatc gacccctcga ccggcttcgt gaacctgctc     4440

aagaccaagt atactagcat tgccgactcc aagaaattca tctcgtcctt cgaccgcatc     4500

atgtacgtcc cggaggagga cctttttgag ttcgccctcg actacaagaa cttcagccgc     4560

accgacgccg actacatcaa gaagtggaag ctgtactcgt acgggaaccg catccgtatt     4620

tttcgcaacc cgaagaaaaa taatgtcttc gactgggagg aggtgtgcct gaccagcgcc     4680

tacaaggagc tgttcaacaa gtacggcatc aactaccaac agggcgacat ccgggccctt     4740

ctctgcgagc agagcgacaa ggcgttctac tcgtcgttca tggccctgat gagcctgatg     4800

ctccagatga ggaacagcat caccggccgc accgacgtgg acttcctcat cagccccgtc     4860

aagaactcgg acggcatatt ttatgactcg cggaactacg aggcccagga gaacgccatc     4920

ctgcccaaga acgccgacgc caacggcgcg tacaacatcg cccgcaaggt gctctgggcc     4980

atcggccagt tcaagaaggc ggaagacgag aagctggaca aggtgaagat cgccatctcc     5040

aacaaggagt ggctggagta cgcgcagacg tccgtcaagc acggctccaa gaaacggcgg     5100

atcaaacaag attccggtgg cagttccggt ggcagcagtg cgtcgttagc aagaggcggt     5160

ccaaatgcag tgggactcct aacgacgaac gaaagctttg agaaaaatat caatgaggtc     5220

tacaaccgta cgcgagccga gctagacgct tcttcacgtg acagaagtcg ctctggacta     5280

tcgcgataa                                                             5289


<210>  70
<211>  1762
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Lachnospiraceae bacterium ND2006 (Cas12a), Agrobacterium 
       tumefaciens

<400>  70

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser 
    370                 375                 380                 


Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp 
385                 390                 395                 400 


Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser 
                405                 410                 415     


Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg 
            420                 425                 430         


Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg Ser 
        435                 440                 445             


Gly Gly Ser Ser Gly Gly Ser Met Ser Gly Ser Lys Lys Arg Arg Ile 
    450                 455                 460                 


Lys Gln Asp Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
465                 470                 475                 480 


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
                485                 490                 495     


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
            500                 505                 510         


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
        515                 520                 525             


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
    530                 535                 540                 


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
545                 550                 555                 560 


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
                565                 570                 575     


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
            580                 585                 590         


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
        595                 600                 605             


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
    610                 615                 620                 


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
625                 630                 635                 640 


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
                645                 650                 655     


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
            660                 665                 670         


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
        675                 680                 685             


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
    690                 695                 700                 


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
705                 710                 715                 720 


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
                725                 730                 735     


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
            740                 745                 750         


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
        755                 760                 765             


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
    770                 775                 780                 


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
785                 790                 795                 800 


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
                805                 810                 815     


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
            820                 825                 830         


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
        835                 840                 845             


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
    850                 855                 860                 


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
865                 870                 875                 880 


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
                885                 890                 895     


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
            900                 905                 910         


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
        915                 920                 925             


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
    930                 935                 940                 


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
945                 950                 955                 960 


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
                965                 970                 975     


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
            980                 985                 990         


Asn Pro Gln Phe Met Gly Gly Trp  Asp Lys Asp Lys Glu  Thr Asp Tyr 
        995                 1000                 1005             


Arg Ala  Thr Ile Leu Arg Tyr  Gly Ser Lys Tyr Tyr  Leu Ala Ile 
    1010                 1015                 1020             


Met Asp  Lys Lys Tyr Ala Lys  Cys Leu Gln Lys Ile  Asp Lys Asp 
    1025                 1030                 1035             


Asp Val  Asn Gly Asn Tyr Glu  Lys Ile Asn Tyr Lys  Leu Leu Pro 
    1040                 1045                 1050             


Gly Pro  Asn Lys Met Leu Pro  Lys Val Phe Phe Ser  Lys Lys Trp 
    1055                 1060                 1065             


Met Ala  Tyr Tyr Asn Pro Ser  Glu Asp Ile Gln Lys  Ile Tyr Lys 
    1070                 1075                 1080             


Asn Gly  Thr Phe Lys Lys Gly  Asp Met Phe Asn Leu  Asn Asp Cys 
    1085                 1090                 1095             


His Lys  Leu Ile Asp Phe Phe  Lys Asp Ser Ile Ser  Arg Tyr Pro 
    1100                 1105                 1110             


Lys Trp  Ser Asn Ala Tyr Asp  Phe Asn Phe Ser Glu  Thr Glu Lys 
    1115                 1120                 1125             


Tyr Lys  Asp Ile Ala Gly Phe  Tyr Arg Glu Val Glu  Glu Gln Gly 
    1130                 1135                 1140             


Tyr Lys  Val Ser Phe Glu Ser  Ala Ser Lys Lys Glu  Val Asp Lys 
    1145                 1150                 1155             


Leu Val  Glu Glu Gly Lys Leu  Tyr Met Phe Gln Ile  Tyr Asn Lys 
    1160                 1165                 1170             


Asp Phe  Ser Asp Lys Ser His  Gly Thr Pro Asn Leu  His Thr Met 
    1175                 1180                 1185             


Tyr Phe  Lys Leu Leu Phe Asp  Glu Asn Asn His Gly  Gln Ile Arg 
    1190                 1195                 1200             


Leu Ser  Gly Gly Ala Glu Leu  Phe Met Arg Arg Ala  Ser Leu Lys 
    1205                 1210                 1215             


Lys Glu  Glu Leu Val Val His  Pro Ala Asn Ser Pro  Ile Ala Asn 
    1220                 1225                 1230             


Lys Asn  Pro Asp Asn Pro Lys  Lys Thr Thr Thr Leu  Ser Tyr Asp 
    1235                 1240                 1245             


Val Tyr  Lys Asp Lys Arg Phe  Ser Glu Asp Gln Tyr  Glu Leu His 
    1250                 1255                 1260             


Ile Pro  Ile Ala Ile Asn Lys  Cys Pro Lys Asn Ile  Phe Lys Ile 
    1265                 1270                 1275             


Asn Thr  Glu Val Arg Val Leu  Leu Lys His Asp Asp  Asn Pro Tyr 
    1280                 1285                 1290             


Val Ile  Gly Ile Asp Arg Gly  Glu Arg Asn Leu Leu  Tyr Ile Val 
    1295                 1300                 1305             


Val Val  Asp Gly Lys Gly Asn  Ile Val Glu Gln Tyr  Ser Leu Asn 
    1310                 1315                 1320             


Glu Ile  Ile Asn Asn Phe Asn  Gly Ile Arg Ile Lys  Thr Asp Tyr 
    1325                 1330                 1335             


His Ser  Leu Leu Asp Lys Lys  Glu Lys Glu Arg Phe  Glu Ala Arg 
    1340                 1345                 1350             


Gln Asn  Trp Thr Ser Ile Glu  Asn Ile Lys Glu Leu  Lys Ala Gly 
    1355                 1360                 1365             


Tyr Ile  Ser Gln Val Val His  Lys Ile Cys Glu Leu  Val Glu Lys 
    1370                 1375                 1380             


Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu Asn Ser  Gly Phe Lys 
    1385                 1390                 1395             


Asn Ser  Arg Val Lys Val Glu  Lys Gln Val Tyr Gln  Lys Phe Glu 
    1400                 1405                 1410             


Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met Val Asp  Lys Lys Ser 
    1415                 1420                 1425             


Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys Gly Tyr  Gln Ile Thr 
    1430                 1435                 1440             


Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser Thr Gln  Asn Gly Phe 
    1445                 1450                 1455             


Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
    1460                 1465                 1470             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1475                 1480                 1485             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1490                 1495                 1500             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1505                 1510                 1515             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1520                 1525                 1530             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1535                 1540                 1545             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1550                 1555                 1560             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1565                 1570                 1575             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1580                 1585                 1590             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1595                 1600                 1605             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1610                 1615                 1620             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1625                 1630                 1635             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1640                 1645                 1650             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1655                 1660                 1665             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1670                 1675                 1680             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Gly  Ser Lys Lys 
    1685                 1690                 1695             


Arg Arg  Ile Lys Gln Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser 
    1700                 1705                 1710             


Ala Ser  Leu Ala Arg Gly Gly  Pro Asn Ala Val Gly  Leu Leu Thr 
    1715                 1720                 1725             


Thr Asn  Glu Ser Phe Glu Lys  Asn Ile Asn Glu Val  Tyr Asn Arg 
    1730                 1735                 1740             


Thr Arg  Ala Glu Leu Asp Ala  Ser Ser Arg Asp Arg  Ser Arg Ser 
    1745                 1750                 1755             


Gly Leu  Ser Arg 
    1760         


<210>  71
<211>  1605
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Agrobacterium tumefaciens (Vir), synthetic (SH3), Simian virus 40
       (NLS) fusion

<400>  71
atgcccgatc gagctcaagt tatcattcgc attgtgccgg gaggtggcac caagaccctt       60

caacaaatta tcaatcagtt ggagtatcta tcccggaagg gcaggctgga gctgcagcgt      120

tcagcccgac atctcgatat tcccctgcca ccggatcaaa tccacgaact tgcccgaagc      180

tgggttcaag agactggaac ttatgacgaa agtcagccag acgaggaaag gcaacaggag      240

ttgaccaccc atattattgt aagcttcccc gccggtacaa gccaggtagc ggcttatgcg      300

gcgagccggg agtgggcagc cgagatgttt gggtcaggcg cagggggggg ccgatacaac      360

tatcttacgg ccttccacat cgatcgcgac cacccacatc tgcatgtcgt cgtcaatcgg      420

cgcgaacttt taggacacgg ctggctgaag atatctcggc gccatcccca actgaattac      480

gacgccctgc gcataaagat ggccgagatt tcacttcgtc atggcattgc cctcgatgcg      540

agccgacgag cagaacgtgg catcaccgag cggccgatca cttatgccca atatcggcgc      600

cttgagcggg agcaggctcg ccaaatccgt ttcgaagacg cggatttgga acagtcgtcg      660

ccgcaaggag atcatccaga attcagccaa cctttcgata catccccatt tgaagcatcc      720

gcgggcggac cggaggacat gcctcggccc aacaatcggc agaatgagtc gcaagttcat      780

ctccaggagc cagctggtgt cagcaacgaa gccggtgtcc ttgtgcgggt tgcattggaa      840

acggagcgcc ttgctcaacc attcgtttcc gaaaccattc tcgcggacga catagggagc      900

ggctcttcgc gtgttgccga gggccgtgtg gagagcgcaa accgcactcc cgatattcct      960

cgcgcagcaa ctgaagctgc cacgcacacg acacacgacc ggcagcggcg tgcaaagcgt     1020

cctcatgatg acgacggagg gccgagtgga gcaaaacgtg tgacattgga aggcatcgcg     1080

gttgggcccc aggcgaacgc cggcgaacag gatggcagta gtgggggctc ctcgggtggc     1140

agcatgagcg gatcaaaaaa aagaaggatc aagcaagatg cggagtacgt gcgtgctttg     1200

tttgatttca acggcaacga tgaagaagac ctgccattca aaaagggcga catcctgcgt     1260

attcgtgata aaccggaaga gcagtggtgg aatgcagagg acagcgaagg taagcgcggt     1320

atgatcccgg ttccgtatgt cgagaagtac tccggtagtg gggggtcctc tggtggaagt     1380

agtggcccct tagtacggca agctggaacg tcacggccat ctccaccgac ggccacgacg     1440

cgggccagca ccgcaaccga ttcattgtct gctacagccc acctccagca acggagaggt     1500

gtcctttcaa agcgtccgcg tgaagatgat gatggagaac cgagtgaacg caaacgcgag     1560

agagatgagc gcagcaagga cgggcgtggg ggaaatagga gatag                     1605


<210>  72
<211>  23
<212>  DNA
<213>  Glycine max

<400>  72
tgtgtgatgt tcgatgttgg att                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Glycine max

<400>  73
ttgtaaccaa catcccctga tga                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Glycine max

<400>  74
acacctactc atctggccat tgt                                               23


<210>  75
<211>  96
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BE4 Linker Agrobacterium codon optimized nucleotide sequence

<400>  75
tccggtggaa gttccggagg ttcaagcggg tctgaaacgc cgggcaccag cgagtcggcg       60

accccggaaa gcagcggtgg ttcttccggc ggtagc                                 96


<210>  76
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BE4 Linker amino acid sequence

<400>  76

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  77
<211>  53
<212>  DNA
<213>  Escherichia coli

<400>  77
ttgacagcta gctcagtcct aggtactgtg ctagcgctag caaagaggag aaa              53


<210>  78
<211>  129
<212>  DNA
<213>  Escherichia coli

<400>  78
ccaggcatca aataaaacga aaggctcagt cgaaagactg ggcctttcgt tttatctgtt       60

gtttgtcggt gaacgctctc tactagagtc acactggctc accttcgggt gggcctttct      120

gcgtttata                                                              129


<210>  79
<211>  10816
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pWISE3104 Full plasmid sequence

<400>  79
cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccggga tgagattatc       60

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag      120

tatatatgtg taacattggt ctagtgattg gatccttgac agctagctca gtcctaggta      180

ctgtgctagc gctagcaaag aggagaaagg taccatgagc ggctccaaga agcgccgcat      240

caagcaagat tcaaagctgg agaagttcac caactgctac tcgctgagca agacgctgcg      300

gttcaaggcc atccccgtgg gcaagaccca ggagaacatc gacaacaagc gcctcctggt      360

cgaggacgag aagcgcgccg aggactacaa gggcgtcaag aagctcctgg accggtatta      420

cctcagcttc atcaacgacg tgctgcactc gatcaagctc aagaacctga acaactacat      480

cagcctgttc cgcaagaaaa cgcgcaccga gaaggagaac aaagagctgg agaacctgga      540

gatcaacctg cggaaggaga ttgcgaaagc tttcaagggc aacgagggct acaagtcgct      600

cttcaagaaa gacataatcg agaccatcct gccggagttc ctggacgaca aggacgagat      660

cgcgctcgtc aactcgttca acgggttcac tacggccttc acgggtttct tcgataaccg      720

ggagaatatg tttagcgagg aggccaagtc cacctccatt gcgttccgct gcatcaacga      780

gaacctgacc cgctacatca gcaacatgga catcttcgag aaggtggacg ccatcttcga      840

caagcacgag gtccaggaga tcaaggagaa gattctgaac tcggactacg acgtggaaga      900

cttcttcgag ggcgagtttt tcaacttcgt cctgacccag gaggggatcg acgtttataa      960

cgccatcatc ggcgggttcg tcacggagtc gggcgaaaag atcaagggcc tgaacgagta     1020

tattaacctg tacaaccaga agacaaagca gaagctgccg aagttcaagc cgctgtacaa     1080

gcaagtcctg tccgaccgcg agtcgctgtc gttctacggc gaaggctaca cctcggacga     1140

ggaggtgctg gaggtgttcc gcaacaccct gaacaagaat agcgaaattt ttagctccat     1200

taagaagctc gagaagctgt tcaagaactt cgacgagtac agcagcgccg ggatcttcgt     1260

caagaacggc cccgcgatca gcaccatctc gaaggacatc ttcggcgagt ggaacgtcat     1320

ccgggacaag tggaacgccg agtacgacga cattcacctt aaaaagaagg ctgttgtgac     1380

ggagaagtac gaggacgacc ggcgcaagtc gttcaaaaag atcggctcct tctccctgga     1440

gcagctccag gagtacgccg acgccgacct ctcggtcgtc gagaagctca aggagatcat     1500

cattcagaag gtggacgaaa tttacaaagt gtacggctcc agcgagaagc tgttcgacgc     1560

cgacttcgtg ctggaaaagt cgctcaagaa aaacgacgcc gtggtggcca tcatgaagga     1620

cttgctggac agcgtgaagt cgttcgagaa ctacattaag gcgttctttg gcgagggcaa     1680

ggagaccaac cgcgacgagt cgttctacgg cgacttcgtg ctcgcgtacg acatcctgct     1740

caaggtggat cacatctacg acgcgatccg caactacgtc acgcagaagc cgtactcgaa     1800

ggacaagttc aagctgtact tccagaaccc gcagttcatg ggcgggtggg acaaggacaa     1860

ggaaacggac taccgcgcga ccatcctgcg gtacggcagc aagtattatc tggcgatcat     1920

ggacaaaaaa tatgccaagt gcctccagaa aatcgacaag gacgacgtga acggcaacta     1980

cgagaagatt aattacaagc tgctccccgg ccccaacaag atgctcccga aggtgttctt     2040

tagcaagaag tggatggcct actacaaccc gagcgaggac atccagaaga tctataagaa     2100

tggcaccttc aagaagggag acatgtttaa cctcaacgac tgccacaagc tgattgactt     2160

cttcaaggac tcgatctcgc gctacccgaa gtggtcgaac gcctacgact tcaacttcag     2220

cgaaacggag aaatacaaag acatcgcggg cttctaccgc gaggtcgagg agcaaggcta     2280

caaggtcagc ttcgagtccg ccagcaagaa ggaggtggac aagctggtgg aggagggcaa     2340

gctctacatg tttcagatct acaacaagga ttttagcgac aagtcgcacg gcacgccgaa     2400

cctgcacacg atgtacttca agctgctgtt cgacgagaac aaccacggcc agatccggct     2460

gtcgggcggt gcggagctgt tcatgcgccg ggcgtcgctc aagaaggaag agctggtcgt     2520

ccacccggcc aacagcccca tcgccaacaa gaaccccgac aaccccaaga aaacgacgac     2580

actcagctat gatgtctata aagacaagcg cttctcggag gaccagtacg agctgcacat     2640

ccccatcgcc atcaacaagt gccccaagaa catcttcaag atcaacacgg aggtccgcgt     2700

gctcctcaag cacgacgaca acccgtacgt catcggcatc gaccggggcg agcgcaacct     2760

gctgtacatc gtcgtcgtcg atggcaaggg caacatcgtg gagcagtatt ccctgaacga     2820

gatcatcaac aacttcaacg gcatccgcat caagaccgac taccactccc tcctcgacaa     2880

gaaggagaaa gagcgcttcg aggcccgcca gaactggacc tccatcgaga acatcaagga     2940

gcttaaggcg ggctacatct cccaagtcgt ccacaagatc tgcgagctgg tcgagaagta     3000

cgacgcggtg atcgccctgg aagacctgaa ctccggcttc aagaactccc gcgtaaaggt     3060

ggagaagcaa gtgtaccaga agttcgagaa gatgctgatc gacaagctga actacatggt     3120

ggacaagaaa tcgaacccgt gcgcgaccgg cggcgcgctc aagggctacc agatcacgaa     3180

caagttcgag tcgttcaagt ccatgagcac gcagaacggc tttatcttct acatcccggc     3240

ctggctgacg tcgaagatcg acccctcgac cggcttcgtg aacctgctca agaccaagta     3300

tactagcatt gccgactcca agaaattcat ctcgtccttc gaccgcatca tgtacgtccc     3360

ggaggaggac ctttttgagt tcgccctcga ctacaagaac ttcagccgca ccgacgccga     3420

ctacatcaag aagtggaagc tgtactcgta cgggaaccgc atccgtattt ttcgcaaccc     3480

gaagaaaaat aatgtcttcg actgggagga ggtgtgcctg accagcgcct acaaggagct     3540

gttcaacaag tacggcatca actaccaaca gggcgacatc cgggcccttc tctgcgagca     3600

gagcgacaag gcgttctact cgtcgttcat ggccctgatg agcctgatgc tccagatgag     3660

gaacagcatc accggccgca ccgacgtgga cttcctcatc agccccgtca agaactcgga     3720

cggcatattt tatgactcgc ggaactacga ggcccaggag aacgccatcc tgcccaagaa     3780

cgccgacgcc aacggcgcgt acaacatcgc ccgcaaggtg ctctgggcca tcggccagtt     3840

caagaaggcg gaagacgaga agctggacaa ggtgaagatc gccatctcca acaaggagtg     3900

gctggagtac gcgcagacgt ccgtcaagca cggctccaag aaacggcgga tcaaacaaga     3960

ttccggtgga agttccggag gttcaagcgg gtctgaaacg ccgggcacca gcgagtcggc     4020

gaccccggaa agcagcggtg gttcttccgg cggtagcatg cccgatcgag ctcaagttat     4080

cattcgcatt gtgccgggag gtggcaccaa gacccttcaa caaattatca atcagttgga     4140

gtatctatcc cggaagggca ggctggagct gcagcgttca gcccgacatc tcgatattcc     4200

cctgccaccg gatcaaatcc acgaacttgc ccgaagctgg gttcaagaga ctggaactta     4260

tgacgaaagt cagccagacg aggaaaggca acaggagttg accacccata ttattgtaag     4320

cttccccgcc ggtacaagcc aggtagcggc ttatgcggcg agccgggagt gggcagccga     4380

gatgtttggg tcaggcgcag gggggggccg atacaactat cttacggcct tccacatcga     4440

tcgcgaccac ccacatctgc atgtcgtcgt caatcggcgc gaacttttag gacacggctg     4500

gctgaagata tctcggcgcc atccccaact gaattacgac gccctgcgca taaagatggc     4560

cgagatttca cttcgtcatg gcattgccct cgatgcgagc cgacgagcag aacgtggcat     4620

caccgagcgg ccgatcactt atgcccaata tcggcgcctt gagcgggagc aggctcgcca     4680

aatccgtttc gaagacgcgg atttggaaca gtcgtcgccg caaggagatc atccagaatt     4740

cagccaacct ttcgatacat ccccatttga agcatccgcg ggcggaccgg aggacatgcc     4800

tcggcccaac aatcggcaga atgagtcgca agttcatctc caggagccag ctggtgtcag     4860

caacgaagcc ggtgtccttg tgcgggttgc attggaaacg gagcgccttg ctcaaccatt     4920

cgtttccgaa accattctcg cggacgacat agggagcggc tcttcgcgtg ttgccgaggg     4980

ccgtgtggag agcgcaaacc gcactcccga tattcctcgc gcagcaactg aagctgccac     5040

gcacacgaca cacgaccggc agcggcgtgc aaagcgtcct catgatgacg acggagggcc     5100

gagtggagca aaacgtgtga cattggaagg catcgcggtt gggccccagg cgaacgccgg     5160

cgaacaggat ggcagtagtg gccccttagt acggcaagct ggaacgtcac ggccatctcc     5220

accgacggcc acgacgcggg ccagcaccgc aaccgattca ttgtctgcta cagcccacct     5280

ccagcaacgg agaggtgtcc tttcaaagcg tccgcgtgaa gatgatgatg gagaaccgag     5340

tgaacgcaaa cgcgagagag atgagcgcag caaggacggg cgtgggggaa ataggagata     5400

gtctagacca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt     5460

atctgttgtt tgtcggtgaa cgctctctac tagagtcaca ctggctcacc ttcgggtggg     5520

cctttctgcg tttatagtac gatatcccaa tggcgcgccg agcttggctc gagcatggtc     5580

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg     5640

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt     5700

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg     5760

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct cgctcactga     5820

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     5880

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     5940

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     6000

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     6060

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     6120

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     6180

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     6240

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     6300

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     6360

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     6420

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     6480

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     6540

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     6600

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     6660

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     6720

gtaaacttgg tctgacagtt agaaaaactc atcgagcatc aaatgaaact gcaatttatt     6780

catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa     6840

ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg     6900

tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa     6960

atcaccatga gtgacgactg aatccggtga gaatggcaaa agtttatgca tttctttcca     7020

gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc     7080

gttattcatt cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt taaaaggaca     7140

attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt     7200

ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccag ggatcgcagt     7260

ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat     7320

aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc     7380

tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt     7440

cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat     7500

gttggaattt aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc tcatactctt     7560

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     7620

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     7680

acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac     7740

gaggcccttt tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct     7800

cccggagact gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg     7860

cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat     7920

tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata     7980

ccgcatcagg cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg     8040

ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg     8100

ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgacgcg     8160

ttgcggctgc atgaaatcct ggccggtttg tctgatgcca agctggcggc ctggccggcc     8220

agcttggccg ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt atttgagtaa     8280

aacagcttgc gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa acaaatacgc     8340

aaggggaacg catgaaggtt atcgctgtac ttaaccagaa aggcgggtca ggcaagacga     8400

ccatcgcaac ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt ctgttagtcg     8460

attccgatcc ccagggcagt gcccgcgatt gggcggccgt gcgggaagat caaccgctaa     8520

ccgttgtcgg catcgaccgc ccgacgattg accgcgacgt gaaggccatc ggccggcgcg     8580

acttcgtagt gatcgacgga gcgccccagg cggcggactt ggctgtgtcc gcgatcaagg     8640

cagccgactt cgtgctgatt ccggtgcagc caagccctta cgacatatgg gccaccgccg     8700

acctggtgga gctggttaag cagcgcattg aggtcacgga tggaaggcta caagcggcct     8760

ttgtcgtgtc gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc gaggcgctgg     8820

ccgggtacga gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc tacccaggca     8880

ctgccgccgc cggcacaacc gttcttgaat cagaacccga gggcgacgct gcccgcgagg     8940

tccaggcgct ggccgctgaa attaaatcaa aactcatttg agttaatgag gtaaagagaa     9000

aatgagcaaa agcacaaaca cgctaagtgc cggccgtccg agcgcacgca gcagcaaggc     9060

tgcaacgttg gccagcctgg cagacacgcc agccatgaag cgggtcaact ttcagttgcc     9120

ggcggaggat cacaccaagc tgaagatgta cgcggtacgc caaggcaaga ccattaccga     9180

gctgctatct gaatacatcg cgcagctacc agagtaaatg agcaaatgaa taaatgagta     9240

gatgaatttt agcggctaaa ggaggcggca tggaaaatca agaacaacca ggcaccgacg     9300

ccgtggaatg ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc ggctgggttg     9360

tctgccggcc ctgcaatggc actggaaccc ccaagcccga ggaatcggcg tgagcggtcg     9420

caaaccatcc ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg tggagaagtt     9480

gaaggccgcg caggccgccc agcggcaacg catcgaggca gaagcacgcc ccggtgaatc     9540

gtggcaagcg gccgctgatc gaatccgcaa agaatcccgg caaccgccgg cagccggtgc     9600

gccgtcgatt aggaagccgc ccaagggcga cgagcaacca gattttttcg ttccgatgct     9660

ctatgacgtg ggcacccgcg atagtcgcag catcatggac gtggccgttt tccgtctgtc     9720

gaagcgtgac cgacgagctg gcgaggtgat ccgctacgag cttccagacg ggcacgtaga     9780

ggtttccgca gggccggccg gcatggccag tgtgtgggat tacgacctgg tactgatggc     9840

ggtttcccat ctaaccgaat ccatgaaccg ataccgggaa gggaagggag acaagcccgg     9900

ccgcgtgttc cgtccacacg ttgcggacgt actcaagttc tgccggcgag ccgatggcgg     9960

aaagcagaaa gacgacctgg tagaaacctg cattcggtta aacaccacgc acgttgccat    10020

gcagcgtacg aagaaggcca agaacggccg cctggtgacg gtatccgagg gtgaagcctt    10080

gattagccgc tacaagatcg taaagagcga aaccgggcgg ccggagtaca tcgagatcga    10140

gctagctgat tggatgtacc gcgagatcac agaaggcaag aacccggacg tgctgacggt    10200

tcaccccgat tactttttga tcgatcccgg catcggccgt tttctctacc gcctggcacg    10260

ccgcgccgca ggcaaggcag aagccagatg gttgttcaag acgatctacg aacgcagtgg    10320

cagcgccgga gagttcaaga agttctgttt caccgtgcgc aagctgatcg ggtcaaatga    10380

cctgccggag tacgatttga aggaggaggc ggggcaggct ggcccgatcc tagtcatgcg    10440

ctaccgcaac ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg agcagatgct    10500

agggcaaatt gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg tggatagcac    10560

gtacattggg aacccaaagc cgtacattgg gaaccggaac ccgtacattg ggaacccaaa    10620

gccgtacatt gggaaccggt cacacatgta agtgactgat ataaaagaga aaaaaggcga    10680

tttttccgcc taaaactctt taaaacttat taaaactctt aaaacccgcc tggcctgtgc    10740

atatgctagt catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg    10800

gcatcggtcg agatcc                                                    10816


<210>  80
<211>  11289
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pWISE3452 Full plasmid sequence

<400>  80
cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccggga tgagattatc       60

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag      120

tatatatgtg taacattggt ctagtgattg gatccggaga ctcgaccagg gtaatcagca      180

cgtctgttcg gcgcgcctat agctatggtt tctcgcaatc gctttgggca gtcggttgtg      240

gcggtgcgtc ttctgagacc cgaaggttgg cgattatctg ctggaggtct tcgataccgt      300

cttcgaagaa caagacatat gttcgctgag ctcggacata ggatagtcgg cataggcgga      360

taccctcgcc acgcaaatgg cgcgatcgac accctgatcg gagcctgcga agtgccacag      420

tttattggaa ccatcccccg ttcattccgc cctggaattt cacttcgacg gcattctaga      480

tcctcgccgt tgtcttagag agccatcttt cgtcggcgca cccttaagtg catggaaagc      540

cgttttcgct tcaaatgaaa tcgaaaagaa gaaaacaaaa atcctagagt aaccgaccct      600

cccgataatc gtgaacatca gatgacagca tttcttccga ccgaagtggc tgtgttggtt      660

atgagcttgg ggagatgggg aggtaccatg agcggctcca agaagcgccg catcaagcaa      720

gattcaaagc tggagaagtt caccaactgc tactcgctga gcaagacgct gcggttcaag      780

gccatccccg tgggcaagac ccaggagaac atcgacaaca agcgcctcct ggtcgaggac      840

gagaagcgcg ccgaggacta caagggcgtc aagaagctcc tggaccggta ttacctcagc      900

ttcatcaacg acgtgctgca ctcgatcaag ctcaagaacc tgaacaacta catcagcctg      960

ttccgcaaga aaacgcgcac cgagaaggag aacaaagagc tggagaacct ggagatcaac     1020

ctgcggaagg agattgcgaa agctttcaag ggcaacgagg gctacaagtc gctcttcaag     1080

aaagacataa tcgagaccat cctgccggag ttcctggacg acaaggacga gatcgcgctc     1140

gtcaactcgt tcaacgggtt cactacggcc ttcacgggtt tcttcgataa ccgggagaat     1200

atgtttagcg aggaggccaa gtccacctcc attgcgttcc gctgcatcaa cgagaacctg     1260

acccgctaca tcagcaacat ggacatcttc gagaaggtgg acgccatctt cgacaagcac     1320

gaggtccagg agatcaagga gaagattctg aactcggact acgacgtgga agacttcttc     1380

gagggcgagt ttttcaactt cgtcctgacc caggagggga tcgacgttta taacgccatc     1440

atcggcgggt tcgtcacgga gtcgggcgaa aagatcaagg gcctgaacga gtatattaac     1500

ctgtacaacc agaagacaaa gcagaagctg ccgaagttca agccgctgta caagcaagtc     1560

ctgtccgacc gcgagtcgct gtcgttctac ggcgaaggct acacctcgga cgaggaggtg     1620

ctggaggtgt tccgcaacac cctgaacaag aatagcgaaa tttttagctc cattaagaag     1680

ctcgagaagc tgttcaagaa cttcgacgag tacagcagcg ccgggatctt cgtcaagaac     1740

ggccccgcga tcagcaccat ctcgaaggac atcttcggcg agtggaacgt catccgggac     1800

aagtggaacg ccgagtacga cgacattcac cttaaaaaga aggctgttgt gacggagaag     1860

tacgaggacg accggcgcaa gtcgttcaaa aagatcggct ccttctccct ggagcagctc     1920

caggagtacg ccgacgccga cctctcggtc gtcgagaagc tcaaggagat catcattcag     1980

aaggtggacg aaatttacaa agtgtacggc tccagcgaga agctgttcga cgccgacttc     2040

gtgctggaaa agtcgctcaa gaaaaacgac gccgtggtgg ccatcatgaa ggacttgctg     2100

gacagcgtga agtcgttcga gaactacatt aaggcgttct ttggcgaggg caaggagacc     2160

aaccgcgacg agtcgttcta cggcgacttc gtgctcgcgt acgacatcct gctcaaggtg     2220

gatcacatct acgacgcgat ccgcaactac gtcacgcaga agccgtactc gaaggacaag     2280

ttcaagctgt acttccagaa cccgcagttc atgggcgggt gggacaagga caaggaaacg     2340

gactaccgcg cgaccatcct gcggtacggc agcaagtatt atctggcgat catggacaaa     2400

aaatatgcca agtgcctcca gaaaatcgac aaggacgacg tgaacggcaa ctacgagaag     2460

attaattaca agctgctccc cggccccaac aagatgctcc cgaaggtgtt ctttagcaag     2520

aagtggatgg cctactacaa cccgagcgag gacatccaga agatctataa gaatggcacc     2580

ttcaagaagg gagacatgtt taacctcaac gactgccaca agctgattga cttcttcaag     2640

gactcgatct cgcgctaccc gaagtggtcg aacgcctacg acttcaactt cagcgaaacg     2700

gagaaataca aagacatcgc gggcttctac cgcgaggtcg aggagcaagg ctacaaggtc     2760

agcttcgagt ccgccagcaa gaaggaggtg gacaagctgg tggaggaggg caagctctac     2820

atgtttcaga tctacaacaa ggattttagc gacaagtcgc acggcacgcc gaacctgcac     2880

acgatgtact tcaagctgct gttcgacgag aacaaccacg gccagatccg gctgtcgggc     2940

ggtgcggagc tgttcatgcg ccgggcgtcg ctcaagaagg aagagctggt cgtccacccg     3000

gccaacagcc ccatcgccaa caagaacccc gacaacccca agaaaacgac gacactcagc     3060

tatgatgtct ataaagacaa gcgcttctcg gaggaccagt acgagctgca catccccatc     3120

gccatcaaca agtgccccaa gaacatcttc aagatcaaca cggaggtccg cgtgctcctc     3180

aagcacgacg acaacccgta cgtcatcggc atcgaccggg gcgagcgcaa cctgctgtac     3240

atcgtcgtcg tcgatggcaa gggcaacatc gtggagcagt attccctgaa cgagatcatc     3300

aacaacttca acggcatccg catcaagacc gactaccact ccctcctcga caagaaggag     3360

aaagagcgct tcgaggcccg ccagaactgg acctccatcg agaacatcaa ggagcttaag     3420

gcgggctaca tctcccaagt cgtccacaag atctgcgagc tggtcgagaa gtacgacgcg     3480

gtgatcgccc tggaagacct gaactccggc ttcaagaact cccgcgtaaa ggtggagaag     3540

caagtgtacc agaagttcga gaagatgctg atcgacaagc tgaactacat ggtggacaag     3600

aaatcgaacc cgtgcgcgac cggcggcgcg ctcaagggct accagatcac gaacaagttc     3660

gagtcgttca agtccatgag cacgcagaac ggctttatct tctacatccc ggcctggctg     3720

acgtcgaaga tcgacccctc gaccggcttc gtgaacctgc tcaagaccaa gtatactagc     3780

attgccgact ccaagaaatt catctcgtcc ttcgaccgca tcatgtacgt cccggaggag     3840

gacctttttg agttcgccct cgactacaag aacttcagcc gcaccgacgc cgactacatc     3900

aagaagtgga agctgtactc gtacgggaac cgcatccgta tttttcgcaa cccgaagaaa     3960

aataatgtct tcgactggga ggaggtgtgc ctgaccagcg cctacaagga gctgttcaac     4020

aagtacggca tcaactacca acagggcgac atccgggccc ttctctgcga gcagagcgac     4080

aaggcgttct actcgtcgtt catggccctg atgagcctga tgctccagat gaggaacagc     4140

atcaccggcc gcaccgacgt ggacttcctc atcagccccg tcaagaactc ggacggcata     4200

ttttatgact cgcggaacta cgaggcccag gagaacgcca tcctgcccaa gaacgccgac     4260

gccaacggcg cgtacaacat cgcccgcaag gtgctctggg ccatcggcca gttcaagaag     4320

gcggaagacg agaagctgga caaggtgaag atcgccatct ccaacaagga gtggctggag     4380

tacgcgcaga cgtccgtcaa gcacggctcc aagaaacggc ggatcaaaca agattccggt     4440

ggaagttccg gaggttcaag cgggtctgaa acgccgggca ccagcgagtc ggcgaccccg     4500

gaaagcagcg gtggttcttc cggcggtagc atgcccgatc gagctcaagt tatcattcgc     4560

attgtgccgg gaggtggcac caagaccctt caacaaatta tcaatcagtt ggagtatcta     4620

tcccggaagg gcaggctgga gctgcagcgt tcagcccgac atctcgatat tcccctgcca     4680

ccggatcaaa tccacgaact tgcccgaagc tgggttcaag agactggaac ttatgacgaa     4740

agtcagccag acgaggaaag gcaacaggag ttgaccaccc atattattgt aagcttcccc     4800

gccggtacaa gccaggtagc ggcttatgcg gcgagccggg agtgggcagc cgagatgttt     4860

gggtcaggcg cagggggggg ccgatacaac tatcttacgg ccttccacat cgatcgcgac     4920

cacccacatc tgcatgtcgt cgtcaatcgg cgcgaacttt taggacacgg ctggctgaag     4980

atatctcggc gccatcccca actgaattac gacgccctgc gcataaagat ggccgagatt     5040

tcacttcgtc atggcattgc cctcgatgcg agccgacgag cagaacgtgg catcaccgag     5100

cggccgatca cttatgccca atatcggcgc cttgagcggg agcaggctcg ccaaatccgt     5160

ttcgaagacg cggatttgga acagtcgtcg ccgcaaggag atcatccaga attcagccaa     5220

cctttcgata catccccatt tgaagcatcc gcgggcggac cggaggacat gcctcggccc     5280

aacaatcggc agaatgagtc gcaagttcat ctccaggagc cagctggtgt cagcaacgaa     5340

gccggtgtcc ttgtgcgggt tgcattggaa acggagcgcc ttgctcaacc attcgtttcc     5400

gaaaccattc tcgcggacga catagggagc ggctcttcgc gtgttgccga gggccgtgtg     5460

gagagcgcaa accgcactcc cgatattcct cgcgcagcaa ctgaagctgc cacgcacacg     5520

acacacgacc ggcagcggcg tgcaaagcgt cctcatgatg acgacggagg gccgagtgga     5580

gcaaaacgtg tgacattgga aggcatcgcg gttgggcccc aggcgaacgc cggcgaacag     5640

gatggcagta gtggcccctt agtacggcaa gctggaacgt cacggccatc tccaccgacg     5700

gccacgacgc gggccagcac cgcaaccgat tcattgtctg ctacagccca cctccagcaa     5760

cggagaggtg tcctttcaaa gcgtccgcgt gaagatgatg atggagaacc gagtgaacgc     5820

aaacgcgaga gagatgagcg cagcaaggac gggcgtgggg gaaataggag atagtctaga     5880

ccaggcatca aataaaacga aaggctcagt cgaaagactg ggcctttcgt tttatctgtt     5940

gtttgtcggt gaacgctctc tactagagtc acactggctc accttcgggt gggcctttct     6000

gcgtttatag tacgatatcc caatggcgcg ccgagcttgg ctcgagcatg gtcatagctg     6060

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata     6120

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca     6180

ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc     6240

gcggggagag gcggtttgcg tattgggcgc tgttccgctt cctcgctcac tgactcgctg     6300

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta     6360

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc     6420

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     6480

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     6540

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     6600

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     6660

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     6720

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     6780

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     6840

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     6900

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     6960

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     7020

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     7080

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     7140

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     7200

tggtctgaca gttagaaaaa ctcatcgagc atcaaatgaa actgcaattt attcatatca     7260

ggattatcaa taccatattt ttgaaaaagc cgtttctgta atgaaggaga aaactcaccg     7320

aggcagttcc ataggatggc aagatcctgg tatcggtctg cgattccgac tcgtccaaca     7380

tcaatacaac ctattaattt cccctcgtca aaaataaggt tatcaagtga gaaatcacca     7440

tgagtgacga ctgaatccgg tgagaatggc aaaagtttat gcatttcttt ccagacttgt     7500

tcaacaggcc agccattacg ctcgtcatca aaatcactcg catcaaccaa accgttattc     7560

attcgtgatt gcgcctgagc gaaacgaaat acgcgatcgc tgttaaaagg acaattacaa     7620

acaggaatcg aatgcaaccg gcgcaggaac actgccagcg catcaacaat attttcacct     7680

gaatcaggat attcttctaa tacctggaat gctgttttcc cagggatcgc agtggtgagt     7740

aaccatgcat catcaggagt acggataaaa tgcttgatgg tcggaagagg cataaattcc     7800

gtcagccagt ttagtctgac catctcatct gtaacatcat tggcaacgct acctttgcca     7860

tgtttcagaa acaactctgg cgcatcgggc ttcccataca atcgatagat tgtcgcacct     7920

gattgcccga cattatcgcg agcccattta tacccatata aatcagcatc catgttggaa     7980

tttaatcgcg gcctagagca agacgtttcc cgttgaatat ggctcatact cttccttttt     8040

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     8100

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac     8160

gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc     8220

ttttgtctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca gctcccggag     8280

actgtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca gggcgcgtca     8340

gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg catcagagca gattgtactg     8400

agagtgcacc atatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc     8460

aggcgccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct     8520

tcgctattac gccagctggc gaaaggggga tgtgctgcaa ggcgattaag ttgggtaacg     8580

ccagggtttt cccagtcacg acgttgtaaa acgacggcca gtgaattgac gcgttgcggc     8640

tgcatgaaat cctggccggt ttgtctgatg ccaagctggc ggcctggccg gccagcttgg     8700

ccgctgaaga aaccgagcgc cgccgtctaa aaaggtgatg tgtatttgag taaaacagct     8760

tgcgtcatgc ggtcgctgcg tatatgatgc gatgagtaaa taaacaaata cgcaagggga     8820

acgcatgaag gttatcgctg tacttaacca gaaaggcggg tcaggcaaga cgaccatcgc     8880

aacccatcta gcccgcgccc tgcaactcgc cggggccgat gttctgttag tcgattccga     8940

tccccagggc agtgcccgcg attgggcggc cgtgcgggaa gatcaaccgc taaccgttgt     9000

cggcatcgac cgcccgacga ttgaccgcga cgtgaaggcc atcggccggc gcgacttcgt     9060

agtgatcgac ggagcgcccc aggcggcgga cttggctgtg tccgcgatca aggcagccga     9120

cttcgtgctg attccggtgc agccaagccc ttacgacata tgggccaccg ccgacctggt     9180

ggagctggtt aagcagcgca ttgaggtcac ggatggaagg ctacaagcgg cctttgtcgt     9240

gtcgcgggcg atcaaaggca cgcgcatcgg cggtgaggtt gccgaggcgc tggccgggta     9300

cgagctgccc attcttgagt cccgtatcac gcagcgcgtg agctacccag gcactgccgc     9360

cgccggcaca accgttcttg aatcagaacc cgagggcgac gctgcccgcg aggtccaggc     9420

gctggccgct gaaattaaat caaaactcat ttgagttaat gaggtaaaga gaaaatgagc     9480

aaaagcacaa acacgctaag tgccggccgt ccgagcgcac gcagcagcaa ggctgcaacg     9540

ttggccagcc tggcagacac gccagccatg aagcgggtca actttcagtt gccggcggag     9600

gatcacacca agctgaagat gtacgcggta cgccaaggca agaccattac cgagctgcta     9660

tctgaataca tcgcgcagct accagagtaa atgagcaaat gaataaatga gtagatgaat     9720

tttagcggct aaaggaggcg gcatggaaaa tcaagaacaa ccaggcaccg acgccgtgga     9780

atgccccatg tgtggaggaa cgggcggttg gccaggcgta agcggctggg ttgtctgccg     9840

gccctgcaat ggcactggaa cccccaagcc cgaggaatcg gcgtgagcgg tcgcaaacca     9900

tccggcccgg tacaaatcgg cgcggcgctg ggtgatgacc tggtggagaa gttgaaggcc     9960

gcgcaggccg cccagcggca acgcatcgag gcagaagcac gccccggtga atcgtggcaa    10020

gcggccgctg atcgaatccg caaagaatcc cggcaaccgc cggcagccgg tgcgccgtcg    10080

attaggaagc cgcccaaggg cgacgagcaa ccagattttt tcgttccgat gctctatgac    10140

gtgggcaccc gcgatagtcg cagcatcatg gacgtggccg ttttccgtct gtcgaagcgt    10200

gaccgacgag ctggcgaggt gatccgctac gagcttccag acgggcacgt agaggtttcc    10260

gcagggccgg ccggcatggc cagtgtgtgg gattacgacc tggtactgat ggcggtttcc    10320

catctaaccg aatccatgaa ccgataccgg gaagggaagg gagacaagcc cggccgcgtg    10380

ttccgtccac acgttgcgga cgtactcaag ttctgccggc gagccgatgg cggaaagcag    10440

aaagacgacc tggtagaaac ctgcattcgg ttaaacacca cgcacgttgc catgcagcgt    10500

acgaagaagg ccaagaacgg ccgcctggtg acggtatccg agggtgaagc cttgattagc    10560

cgctacaaga tcgtaaagag cgaaaccggg cggccggagt acatcgagat cgagctagct    10620

gattggatgt accgcgagat cacagaaggc aagaacccgg acgtgctgac ggttcacccc    10680

gattactttt tgatcgatcc cggcatcggc cgttttctct accgcctggc acgccgcgcc    10740

gcaggcaagg cagaagccag atggttgttc aagacgatct acgaacgcag tggcagcgcc    10800

ggagagttca agaagttctg tttcaccgtg cgcaagctga tcgggtcaaa tgacctgccg    10860

gagtacgatt tgaaggagga ggcggggcag gctggcccga tcctagtcat gcgctaccgc    10920

aacctgatcg agggcgaagc atccgccggt tcctaatgta cggagcagat gctagggcaa    10980

attgccctag caggggaaaa aggtcgaaaa ggtctctttc ctgtggatag cacgtacatt    11040

gggaacccaa agccgtacat tgggaaccgg aacccgtaca ttgggaaccc aaagccgtac    11100

attgggaacc ggtcacacat gtaagtgact gatataaaag agaaaaaagg cgatttttcc    11160

gcctaaaact ctttaaaact tattaaaact cttaaaaccc gcctggcctg tgcatatgct    11220

agtcatgccc cgcgcccacc ggaaggagct gactgggttg aaggctctca agggcatcgg    11280

tcgagatcc                                                            11289


<210>  81
<211>  7707
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pWISE3592 Full plasmid sequence

<400>  81
accggaagga gctgactggg ttgaaggctc tcaagggcat cggtcgagat cccggtgcct       60

aatgagtgag ctaacttaca ttaattgcgt tgcgccccgg gatgagatta tcaaaaagga      120

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg      180

tgtaacattg gtctagtgat tggatccgga gactcgacca gggtaatcag cacgtctgtt      240

cggcgcgcct atagctatgg tttctcgcaa tcgctttggg cagtcggttg tggcggtgcg      300

tcttctgaga cccgaaggtt ggcgattatc tgctggaggt cttcgatacc gtcttcgaag      360

aacaagacat atgttcgctg agctcggaca taggatagtc ggcataggcg gataccctcg      420

ccacgcaaat ggcgcgatcg acaccctgat cggagcctgc gaagtgccac agtttattgg      480

aaccatcccc cgttcattcc gccctggaat ttcacttcga cggcattcta gatcctcgcc      540

gttgtcttag agagccatct ttcgtcggcg cacccttaag tgcatggaaa gccgttttcg      600

cttcaaatga aatcgaaaag aagaaaacaa aaatcctaga gtaaccgacc ctcccgataa      660

tcgtgaacat cagatgacag catttcttcc gaccgaagtg gctgtgttgg ttatgagctt      720

ggggagatgg ggaggtacca tgcccgatcg agctcaagtt atcattcgca ttgtgccggg      780

aggtggcacc aagacccttc aacaaattat caatcagttg gagtatctat cccggaaggg      840

caggctggag ctgcagcgtt cagcccgaca tctcgatatt cccctgccac cggatcaaat      900

ccacgaactt gcccgaagct gggttcaaga gactggaact tatgacgaaa gtcagccaga      960

cgaggaaagg caacaggagt tgaccaccca tattattgta agcttccccg ccggtacaag     1020

ccaggtagcg gcttatgcgg cgagccggga gtgggcagcc gagatgtttg ggtcaggcgc     1080

aggggggggc cgatacaact atcttacggc cttccacatc gatcgcgacc acccacatct     1140

gcatgtcgtc gtcaatcggc gcgaactttt aggacacggc tggctgaaga tatctcggcg     1200

ccatccccaa ctgaattacg acgccctgcg cataaagatg gccgagattt cacttcgtca     1260

tggcattgcc ctcgatgcga gccgacgagc agaacgtggc atcaccgagc ggccgatcac     1320

ttatgcccaa tatcggcgcc ttgagcggga gcaggctcgc caaatccgtt tcgaagacgc     1380

ggatttggaa cagtcgtcgc cgcaaggaga tcatccagaa ttcagccaac ctttcgatac     1440

atccccattt gaagcatccg cgggcggacc ggaggacatg cctcggccca acaatcggca     1500

gaatgagtcg caagttcatc tccaggagcc agctggtgtc agcaacgaag ccggtgtcct     1560

tgtgcgggtt gcattggaaa cggagcgcct tgctcaacca ttcgtttccg aaaccattct     1620

cgcggacgac atagggagcg gctcttcgcg tgttgccgag ggccgtgtgg agagcgcaaa     1680

ccgcactccc gatattcctc gcgcagcaac tgaagctgcc acgcacacga cacacgaccg     1740

gcagcggcgt gcaaagcgtc ctcatgatga cgacggaggg ccgagtggag caaaacgtgt     1800

gacattggaa ggcatcgcgg ttgggcccca ggcgaacgcc ggcgaacagg atggcagtag     1860

tgggggctcc tcgggtggca gcatgagcgg atcaaaaaaa agaaggatca agcaagatgc     1920

ggagtacgtg cgtgctttgt ttgatttcaa cggcaacgat gaagaagacc tgccattcaa     1980

aaagggcgac atcctgcgta ttcgtgataa accggaagag cagtggtgga atgcagagga     2040

cagcgaaggt aagcgcggta tgatcccggt tccgtatgtc gagaagtact ccggtagtgg     2100

ggggtcctct ggtggaagta gtggcccctt agtacggcaa gctggaacgt cacggccatc     2160

tccaccgacg gccacgacgc gggccagcac cgcaaccgat tcattgtctg ctacagccca     2220

cctccagcaa cggagaggtg tcctttcaaa gcgtccgcgt gaagatgatg atggagaacc     2280

gagtgaacgc aaacgcgaga gagatgagcg cagcaaggac gggcgtgggg gaaataggag     2340

atagtctaga ccaggcatca aataaaacga aaggctcagt cgaaagactg ggcctttcgt     2400

tttatctgtt gtttgtcggt gaacgctctc tactagagtc acactggctc accttcgggt     2460

gggcctttct gcgtttatag tacgatatcc caatggcgcg ccgagcttgg ctcgagcatg     2520

gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc     2580

cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc     2640

gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat     2700

cggccaacgc gcggggagag gcggtttgcg tattgggcgc tgttccgctt cctcgctcac     2760

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     2820

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     2880

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     2940

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     3000

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     3060

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     3120

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     3180

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     3240

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     3300

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     3360

aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     3420

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     3480

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     3540

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     3600

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     3660

tgagtaaact tggtctgaca gttagaaaaa ctcatcgagc atcaaatgaa actgcaattt     3720

attcatatca ggattatcaa taccatattt ttgaaaaagc cgtttctgta atgaaggaga     3780

aaactcaccg aggcagttcc ataggatggc aagatcctgg tatcggtctg cgattccgac     3840

tcgtccaaca tcaatacaac ctattaattt cccctcgtca aaaataaggt tatcaagtga     3900

gaaatcacca tgagtgacga ctgaatccgg tgagaatggc aaaagtttat gcatttcttt     3960

ccagacttgt tcaacaggcc agccattacg ctcgtcatca aaatcactcg catcaaccaa     4020

accgttattc attcgtgatt gcgcctgagc gaaacgaaat acgcgatcgc tgttaaaagg     4080

acaattacaa acaggaatcg aatgcaaccg gcgcaggaac actgccagcg catcaacaat     4140

attttcacct gaatcaggat attcttctaa tacctggaat gctgttttcc cagggatcgc     4200

agtggtgagt aaccatgcat catcaggagt acggataaaa tgcttgatgg tcggaagagg     4260

cataaattcc gtcagccagt ttagtctgac catctcatct gtaacatcat tggcaacgct     4320

acctttgcca tgtttcagaa acaactctgg cgcatcgggc ttcccataca atcgatagat     4380

tgtcgcacct gattgcccga cattatcgcg agcccattta tacccatata aatcagcatc     4440

catgttggaa tttaatcgcg gcctagagca agacgtttcc cgttgaatat ggctcatact     4500

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat     4560

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt     4620

gccacctgac gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat     4680

cacgaggccc ttttgtctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca     4740

gctcccggag actgtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca     4800

gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg catcagagca     4860

gattgtactg agagtgcacc atatgcggtg tgaaataccg cacagatgcg taaggagaaa     4920

ataccgcatc aggcgccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt     4980

gcgggcctct tcgctattac gccagctggc gaaaggggga tgtgctgcaa ggcgattaag     5040

ttgggtaacg ccagggtttt cccagtcacg acgttgtaaa acgacggcca gtgaattgac     5100

gcgttgcggc tgcatgaaat cctggccggt ttgtctgatg ccaagctggc ggcctggccg     5160

gccagcttgg ccgctgaaga aaccgagcgc cgccgtctaa aaaggtgatg tgtatttgag     5220

taaaacagct tgcgtcatgc ggtcgctgcg tatatgatgc gatgagtaaa taaacaaata     5280

cgcaagggga acgcatgaag gttatcgctg tacttaacca gaaaggcggg tcaggcaaga     5340

cgaccatcgc aacccatcta gcccgcgccc tgcaactcgc cggggccgat gttctgttag     5400

tcgattccga tccccagggc agtgcccgcg attgggcggc cgtgcgggaa gatcaaccgc     5460

taaccgttgt cggcatcgac cgcccgacga ttgaccgcga cgtgaaggcc atcggccggc     5520

gcgacttcgt agtgatcgac ggagcgcccc aggcggcgga cttggctgtg tccgcgatca     5580

aggcagccga cttcgtgctg attccggtgc agccaagccc ttacgacata tgggccaccg     5640

ccgacctggt ggagctggtt aagcagcgca ttgaggtcac ggatggaagg ctacaagcgg     5700

cctttgtcgt gtcgcgggcg atcaaaggca cgcgcatcgg cggtgaggtt gccgaggcgc     5760

tggccgggta cgagctgccc attcttgagt cccgtatcac gcagcgcgtg agctacccag     5820

gcactgccgc cgccggcaca accgttcttg aatcagaacc cgagggcgac gctgcccgcg     5880

aggtccaggc gctggccgct gaaattaaat caaaactcat ttgagttaat gaggtaaaga     5940

gaaaatgagc aaaagcacaa acacgctaag tgccggccgt ccgagcgcac gcagcagcaa     6000

ggctgcaacg ttggccagcc tggcagacac gccagccatg aagcgggtca actttcagtt     6060

gccggcggag gatcacacca agctgaagat gtacgcggta cgccaaggca agaccattac     6120

cgagctgcta tctgaataca tcgcgcagct accagagtaa atgagcaaat gaataaatga     6180

gtagatgaat tttagcggct aaaggaggcg gcatggaaaa tcaagaacaa ccaggcaccg     6240

acgccgtgga atgccccatg tgtggaggaa cgggcggttg gccaggcgta agcggctggg     6300

ttgtctgccg gccctgcaat ggcactggaa cccccaagcc cgaggaatcg gcgtgagcgg     6360

tcgcaaacca tccggcccgg tacaaatcgg cgcggcgctg ggtgatgacc tggtggagaa     6420

gttgaaggcc gcgcaggccg cccagcggca acgcatcgag gcagaagcac gccccggtga     6480

atcgtggcaa gcggccgctg atcgaatccg caaagaatcc cggcaaccgc cggcagccgg     6540

tgcgccgtcg attaggaagc cgcccaaggg cgacgagcaa ccagattttt tcgttccgat     6600

gctctatgac gtgggcaccc gcgatagtcg cagcatcatg gacgtggccg ttttccgtct     6660

gtcgaagcgt gaccgacgag ctggcgaggt gatccgctac gagcttccag acgggcacgt     6720

agaggtttcc gcagggccgg ccggcatggc cagtgtgtgg gattacgacc tggtactgat     6780

ggcggtttcc catctaaccg aatccatgaa ccgataccgg gaagggaagg gagacaagcc     6840

cggccgcgtg ttccgtccac acgttgcgga cgtactcaag ttctgccggc gagccgatgg     6900

cggaaagcag aaagacgacc tggtagaaac ctgcattcgg ttaaacacca cgcacgttgc     6960

catgcagcgt acgaagaagg ccaagaacgg ccgcctggtg acggtatccg agggtgaagc     7020

cttgattagc cgctacaaga tcgtaaagag cgaaaccggg cggccggagt acatcgagat     7080

cgagctagct gattggatgt accgcgagat cacagaaggc aagaacccgg acgtgctgac     7140

ggttcacccc gattactttt tgatcgatcc cggcatcggc cgttttctct accgcctggc     7200

acgccgcgcc gcaggcaagg cagaagccag atggttgttc aagacgatct acgaacgcag     7260

tggcagcgcc ggagagttca agaagttctg tttcaccgtg cgcaagctga tcgggtcaaa     7320

tgacctgccg gagtacgatt tgaaggagga ggcggggcag gctggcccga tcctagtcat     7380

gcgctaccgc aacctgatcg agggcgaagc atccgccggt tcctaatgta cggagcagat     7440

gctagggcaa attgccctag caggggaaaa aggtcgaaaa ggtctctttc ctgtggatag     7500

cacgtacatt gggaacccaa agccgtacat tgggaaccgg aacccgtaca ttgggaaccc     7560

aaagccgtac attgggaacc ggtcacacat gtaagtgact gatataaaag agaaaaaagg     7620

cgatttttcc gcctaaaact ctttaaaact tattaaaact cttaaaaccc gcctggcctg     7680

tgcatatgct agtcatgccc cgcgccc                                         7707


<210>  82
<211>  7276
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pWISE3108 Full plasmid sequence

<400>  82
gcgcccaccg gaaggagctg actgggttga aggctctcaa gggcatcggt cgagatcccg       60

gtgcctaatg agtgagctaa cttacattaa ttgcgttgcg ccccgggatg agattatcaa      120

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta      180

tatatgtgta acattggtct agtgattgga tccttgacag ctagctcagt cctaggtact      240

gtgctagcgc tagcaaagag gagaaaggta ccatgagcgg atcaaaaaaa agaaggatca      300

agcaagatgc ggagtacgtg cgtgctttgt ttgatttcaa cggcaacgat gaagaagacc      360

tgccattcaa aaagggcgac atcctgcgta ttcgtgataa accggaagag cagtggtgga      420

atgcagagga cagcgaaggt aagcgcggta tgatcccggt tccgtatgtc gagaagtact      480

ccggtggaag ttccggaggt tcaagcgggt ctgaaacgcc gggcaccagc gagtcggcga      540

ccccggaaag cagcggtggt tcttccggcg gtagcatgcc cgatcgagct caagttatca      600

ttcgcattgt gccgggaggt ggcaccaaga cccttcaaca aattatcaat cagttggagt      660

atctatcccg gaagggcagg ctggagctgc agcgttcagc ccgacatctc gatattcccc      720

tgccaccgga tcaaatccac gaacttgccc gaagctgggt tcaagagact ggaacttatg      780

acgaaagtca gccagacgag gaaaggcaac aggagttgac cacccatatt attgtaagct      840

tccccgccgg tacaagccag gtagcggctt atgcggcgag ccgggagtgg gcagccgaga      900

tgtttgggtc aggcgcaggg gggggccgat acaactatct tacggccttc cacatcgatc      960

gcgaccaccc acatctgcat gtcgtcgtca atcggcgcga acttttagga cacggctggc     1020

tgaagatatc tcggcgccat ccccaactga attacgacgc cctgcgcata aagatggccg     1080

agatttcact tcgtcatggc attgccctcg atgcgagccg acgagcagaa cgtggcatca     1140

ccgagcggcc gatcacttat gcccaatatc ggcgccttga gcgggagcag gctcgccaaa     1200

tccgtttcga agacgcggat ttggaacagt cgtcgccgca aggagatcat ccagaattca     1260

gccaaccttt cgatacatcc ccatttgaag catccgcggg cggaccggag gacatgcctc     1320

ggcccaacaa tcggcagaat gagtcgcaag ttcatctcca ggagccagct ggtgtcagca     1380

acgaagccgg tgtccttgtg cgggttgcat tggaaacgga gcgccttgct caaccattcg     1440

tttccgaaac cattctcgcg gacgacatag ggagcggctc ttcgcgtgtt gccgagggcc     1500

gtgtggagag cgcaaaccgc actcccgata ttcctcgcgc agcaactgaa gctgccacgc     1560

acacgacaca cgaccggcag cggcgtgcaa agcgtcctca tgatgacgac ggagggccga     1620

gtggagcaaa acgtgtgaca ttggaaggca tcgcggttgg gccccaggcg aacgccggcg     1680

aacaggatgg cagtagtggc cccttagtac ggcaagctgg aacgtcacgg ccatctccac     1740

cgacggccac gacgcgggcc agcaccgcaa ccgattcatt gtctgctaca gcccacctcc     1800

agcaacggag aggtgtcctt tcaaagcgtc cgcgtgaaga tgatgatgga gaaccgagtg     1860

aacgcaaacg cgagagagat gagcgcagca aggacgggcg tgggggaaat aggagatagt     1920

ctagaccagg catcaaataa aacgaaaggc tcagtcgaaa gactgggcct ttcgttttat     1980

ctgttgtttg tcggtgaacg ctctctacta gagtcacact ggctcacctt cgggtgggcc     2040

tttctgcgtt tatagtacga tatcccaatg gcgcgccgag cttggctcga gcatggtcat     2100

agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata cgagccggaa     2160

gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta attgcgttgc     2220

gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc     2280

aacgcgcggg gagaggcggt ttgcgtattg ggcgctgttc cgcttcctcg ctcactgact     2340

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     2400

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     2460

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     2520

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     2580

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     2640

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     2700

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     2760

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     2820

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     2880

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagaa     2940

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     3000

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     3060

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     3120

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     3180

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     3240

aaacttggtc tgacagttag aaaaactcat cgagcatcaa atgaaactgc aatttattca     3300

tatcaggatt atcaatacca tatttttgaa aaagccgttt ctgtaatgaa ggagaaaact     3360

caccgaggca gttccatagg atggcaagat cctggtatcg gtctgcgatt ccgactcgtc     3420

caacatcaat acaacctatt aatttcccct cgtcaaaaat aaggttatca agtgagaaat     3480

caccatgagt gacgactgaa tccggtgaga atggcaaaag tttatgcatt tctttccaga     3540

cttgttcaac aggccagcca ttacgctcgt catcaaaatc actcgcatca accaaaccgt     3600

tattcattcg tgattgcgcc tgagcgaaac gaaatacgcg atcgctgtta aaaggacaat     3660

tacaaacagg aatcgaatgc aaccggcgca ggaacactgc cagcgcatca acaatatttt     3720

cacctgaatc aggatattct tctaatacct ggaatgctgt tttcccaggg atcgcagtgg     3780

tgagtaacca tgcatcatca ggagtacgga taaaatgctt gatggtcgga agaggcataa     3840

attccgtcag ccagtttagt ctgaccatct catctgtaac atcattggca acgctacctt     3900

tgccatgttt cagaaacaac tctggcgcat cgggcttccc atacaatcga tagattgtcg     3960

cacctgattg cccgacatta tcgcgagccc atttataccc atataaatca gcatccatgt     4020

tggaatttaa tcgcggccta gagcaagacg tttcccgttg aatatggctc atactcttcc     4080

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg     4140

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac     4200

ctgacgtcta agaaaccatt attatcatga cattaaccta taaaaatagg cgtatcacga     4260

ggcccttttg tctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc     4320

cggagactgt cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg     4380

cgtcagcggg tgttggcggg tgtcggggct ggcttaacta tgcggcatca gagcagattg     4440

tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc     4500

gcatcaggcg ccattcgcca ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg     4560

cctcttcgct attacgccag ctggcgaaag ggggatgtgc tgcaaggcga ttaagttggg     4620

taacgccagg gttttcccag tcacgacgtt gtaaaacgac ggccagtgaa ttgacgcgtt     4680

gcggctgcat gaaatcctgg ccggtttgtc tgatgccaag ctggcggcct ggccggccag     4740

cttggccgct gaagaaaccg agcgccgccg tctaaaaagg tgatgtgtat ttgagtaaaa     4800

cagcttgcgt catgcggtcg ctgcgtatat gatgcgatga gtaaataaac aaatacgcaa     4860

ggggaacgca tgaaggttat cgctgtactt aaccagaaag gcgggtcagg caagacgacc     4920

atcgcaaccc atctagcccg cgccctgcaa ctcgccgggg ccgatgttct gttagtcgat     4980

tccgatcccc agggcagtgc ccgcgattgg gcggccgtgc gggaagatca accgctaacc     5040

gttgtcggca tcgaccgccc gacgattgac cgcgacgtga aggccatcgg ccggcgcgac     5100

ttcgtagtga tcgacggagc gccccaggcg gcggacttgg ctgtgtccgc gatcaaggca     5160

gccgacttcg tgctgattcc ggtgcagcca agcccttacg acatatgggc caccgccgac     5220

ctggtggagc tggttaagca gcgcattgag gtcacggatg gaaggctaca agcggccttt     5280

gtcgtgtcgc gggcgatcaa aggcacgcgc atcggcggtg aggttgccga ggcgctggcc     5340

gggtacgagc tgcccattct tgagtcccgt atcacgcagc gcgtgagcta cccaggcact     5400

gccgccgccg gcacaaccgt tcttgaatca gaacccgagg gcgacgctgc ccgcgaggtc     5460

caggcgctgg ccgctgaaat taaatcaaaa ctcatttgag ttaatgaggt aaagagaaaa     5520

tgagcaaaag cacaaacacg ctaagtgccg gccgtccgag cgcacgcagc agcaaggctg     5580

caacgttggc cagcctggca gacacgccag ccatgaagcg ggtcaacttt cagttgccgg     5640

cggaggatca caccaagctg aagatgtacg cggtacgcca aggcaagacc attaccgagc     5700

tgctatctga atacatcgcg cagctaccag agtaaatgag caaatgaata aatgagtaga     5760

tgaattttag cggctaaagg aggcggcatg gaaaatcaag aacaaccagg caccgacgcc     5820

gtggaatgcc ccatgtgtgg aggaacgggc ggttggccag gcgtaagcgg ctgggttgtc     5880

tgccggccct gcaatggcac tggaaccccc aagcccgagg aatcggcgtg agcggtcgca     5940

aaccatccgg cccggtacaa atcggcgcgg cgctgggtga tgacctggtg gagaagttga     6000

aggccgcgca ggccgcccag cggcaacgca tcgaggcaga agcacgcccc ggtgaatcgt     6060

ggcaagcggc cgctgatcga atccgcaaag aatcccggca accgccggca gccggtgcgc     6120

cgtcgattag gaagccgccc aagggcgacg agcaaccaga ttttttcgtt ccgatgctct     6180

atgacgtggg cacccgcgat agtcgcagca tcatggacgt ggccgttttc cgtctgtcga     6240

agcgtgaccg acgagctggc gaggtgatcc gctacgagct tccagacggg cacgtagagg     6300

tttccgcagg gccggccggc atggccagtg tgtgggatta cgacctggta ctgatggcgg     6360

tttcccatct aaccgaatcc atgaaccgat accgggaagg gaagggagac aagcccggcc     6420

gcgtgttccg tccacacgtt gcggacgtac tcaagttctg ccggcgagcc gatggcggaa     6480

agcagaaaga cgacctggta gaaacctgca ttcggttaaa caccacgcac gttgccatgc     6540

agcgtacgaa gaaggccaag aacggccgcc tggtgacggt atccgagggt gaagccttga     6600

ttagccgcta caagatcgta aagagcgaaa ccgggcggcc ggagtacatc gagatcgagc     6660

tagctgattg gatgtaccgc gagatcacag aaggcaagaa cccggacgtg ctgacggttc     6720

accccgatta ctttttgatc gatcccggca tcggccgttt tctctaccgc ctggcacgcc     6780

gcgccgcagg caaggcagaa gccagatggt tgttcaagac gatctacgaa cgcagtggca     6840

gcgccggaga gttcaagaag ttctgtttca ccgtgcgcaa gctgatcggg tcaaatgacc     6900

tgccggagta cgatttgaag gaggaggcgg ggcaggctgg cccgatccta gtcatgcgct     6960

accgcaacct gatcgagggc gaagcatccg ccggttccta atgtacggag cagatgctag     7020

ggcaaattgc cctagcaggg gaaaaaggtc gaaaaggtct ctttcctgtg gatagcacgt     7080

acattgggaa cccaaagccg tacattggga accggaaccc gtacattggg aacccaaagc     7140

cgtacattgg gaaccggtca cacatgtaag tgactgatat aaaagagaaa aaaggcgatt     7200

tttccgccta aaactcttta aaacttatta aaactcttaa aacccgcctg gcctgtgcat     7260

atgctagtca tgcccc                                                     7276


<210>  83
<211>  18916
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pWISE3776 Full plasmid sequence

<400>  83
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt gtgtgatgtt      480

cgatgttgga tttaatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggttaggatt ttttttcacg aaattgcttc ttgaaattac     6240

gtgatggatt ttgattctga tttatcttgt gattgttgac tctacagatg cagatcttcg     6300

tcaagaccct caccggaaag accatcaccc ttgaggtgga aagctctgac accatcgaca     6360

acgtcaaggc caagatccag gacaaggaag gaattccccc ggatcagcaa cgtctcatct     6420

tcgccggaaa gcagctcgag gacggccgta ccctcgccga ctacaacatc cagaaggagt     6480

caacccttca ccttgtcctt cgtctccgtg gtggcatgca gatcttcgtc aagactctca     6540

ctggcaaaac cataacccta gaggtcgaaa gctctgacac cattgacaac gtcaaggcca     6600

agatccagga caaggaggga atccccccag accagcaacg tctcatcttc gccggaaagc     6660

aacttgagga cgggcgcacc ctcgccgact acaacatcca gaaggaatca acccttcacc     6720

tcgtcctccg tctccgtggt ggcatgcaga tcttcgttaa gaccctcacc ggcaagacta     6780

taaccctaga agtcgagagc tccgacacca tcgacaacgt caaggctaag atccaggaca     6840

aggagggtat ccccccagac cagcagaggc tgatcttcgc cggcaagcag ctcgaggacg     6900

gacgtaccct tgctgactac aacatccaga aggagtcaac tctccacttg gtgttgcgtc     6960

ttcgtggtgg tatgcagatc ttcgtcaaga cccttacggg taagactatt accctcgagg     7020

tggagagctc cgacaccatt gacaatgtga aggcgaagat ccaggacaag gaaggaatcc     7080

caccggacca gcagaggctt atttttgctg gcaaacagct agaggatgga aggaccctcg     7140

ctgactacaa catccagaag gagtcaactc tgcacttggt gttgcgtctt cgtggggggt     7200

tttcaaatgc tgctgatgaa gtggcaactc aattactgaa ttttgacctc ttgaagcttg     7260

ccggtgatgt tgagtctaac cctggaccaa tggcgcaagt tagcagaatc tgcaatggtg     7320

tgcagaaccc atctcttatc tccaatctct cgaaatccag tcaacgcaaa tctcccttat     7380

cggtttctct gaagacgcag cagcatccac gagcttatcc gatttcgtcg tcgtggggat     7440

tgaagaagag tgggatgacg ttaattggct ctgagcttcg tcctcttaag gtcatgtctt     7500

ctgtttccac ggcgtgcatg ggggaagcgg tgatcgccga agtatcgact caactatcag     7560

aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta catttgtacg     7620

gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg gttacggtga     7680

ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg gaaacttcgg     7740

cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt gtgcacgacg     7800

acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa tggcagcgca     7860

atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg gctatcttgc     7920

tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag gaactctttg     7980

atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg ctatggaact     8040

cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc cgcatttggt     8100

acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg gcaatggagc     8160

gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat cttggacaag     8220

aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac tacgtgaaag     8280

gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg atgtctgatg     8340

ttggattttc ccagacattt taagaagaaa tgtgatgtgt aatgggtctg taatgacctt     8400

tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact actgtttgtt     8460

atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg tgtttgaatt     8520

ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc atgcttatca     8580

cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga attattagat     8640

tttggtatta taggttaaag atatttatta ggtagggaga actcttggat tagattctaa     8700

agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat gatccctagt     8760

ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg tgaagcatat     8820

ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta attggcttgc     8880

ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc aattttagtt     8940

atgcaatctt tctgcttcag gtagtccttg tcttacagaa agcacattga gatgatcccc     9000

acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt aaaagatgta     9060

atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc aaaaaatacc     9120

aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat ttgattacca     9180

aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac tggaccccaa     9240

attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt taaaatccca     9300

tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacct aggctggcag     9360

cacatccccc gttcgcgagc tggcgtaaca gcgaagaggc ccgggcgcgc cactgttaat     9420

aatttttaaa cgtcagcgca ctaaaaaaac gaaaagacgg acacgtgaaa ataaaaaaca     9480

cacactagtt tatgacgcaa tactatttta cttatgattt gggtacatta gacaaaaccg     9540

tgaaagagat gtatcagcta tgaaacctgt atacttcaat acagagactt actcatatcg     9600

gatacgtacg cacgaagtat catattaatt attttaattt ttaataaata ttttatcgga     9660

tacttatgtg atactctaca tatacacaag gatatttcta agatacttta tagatacgta     9720

tcctagaaaa acatgaagag taaaaaagtg agacaatgtt gtaaaaattc attataaatg     9780

tatatgattc aattttagat atgcatcagt ataattgatt ctcgatgaaa cacttaaaat     9840

tatatttctt gtggaagaac gtagcgagag aggtgattca gttagacaac attaaataaa     9900

attaatgtta agttctttta atgatgtttc tctcaatatc acatcatatg aaaatgtaat     9960

atgatttata agaaaatttt taaaaaattt attttaataa tcacatgtac tattttttaa    10020

aaattgtatc ttttataata atacaataat aaagagtaat cagtgttaat ttttcttcaa    10080

atataagttt tattataaat cattgttaac gtatcataag tcattaccgt atcgtatctt    10140

aatttttttt taaaaaccgc taattcacgt acccgtattg tattgtaccc gcacctgtat    10200

cacaatcgat cttagttaga agaattgtct cgaggcggtg caagacagca tataatagac    10260

gtggactctc ttataccaaa cgttgtcgta tcacaaaggg ttaggtaaca agtcacagtt    10320

tgtccacgtg tcacgtttta attggaagag gtgccgttgg cgtaatataa cagccaatcg    10380

atttttgcta taaaagcaaa tcaggtaaac taaacttctt cattcttttc ttccccatcg    10440

ctacaaaacc ggttcctttg gaaaagagat tcattcaaac ctagcaccca attccgtttc    10500

aaggtataat ctactttcta ttcttcgatt attttattat tattagctac tatcgtttaa    10560

tcgatctttt cttttgatcc gtcaaattta aattcaatta gggttttgtt cttttctttc    10620

atctgattga aatccttctg aattgaaccg tttacttgat tttactgttt attgtatgat    10680

ttaatccttt gtttttcaaa gacagtcttt agattgtgat taggggttca tataaatttt    10740

tagatttgga tttttgtatt gtatgattca aaaaatacgt cctttaatta gattagtaca    10800

tggatatttt ttacccgatt tattgattgt cagggagaat ttgatgagca agtttttttg    10860

atgtctgttg taaattgaat tgattataat tgctgatctg ctgcttccag ttttcataac    10920

ccatattctt ttaaccttgt tgtacacaca atgaaaaatt ggtgattgat tcatttgttt    10980

ttctttgttt tggattatac agggtggtac caaaaaatgg cgggatctaa gaagagaaga    11040

attaaacaag attccaagct ggagaagttt acaaactgtt acagcctctc caaaaccctc    11100

aggtttaaag cgatcccggt gggcaagacc caggagaaca tcgacaacaa gaggctcctg    11160

gtggaagacg agaagcgcgc cgaagactac aagggcgtga agaagctgct cgataggtac    11220

tacctcagct ttattaacga cgtgctgcac agcatcaaac tcaagaatct caacaactac    11280

atctccctct tccgcaaaaa gacccgcacc gagaaggaga acaaggagct ggagaacctg    11340

gagatcaacc tccgcaagga aatcgccaaa gcgttcaagg gcaatgaagg gtacaagagc    11400

ctcttcaaga aagacatcat cgaaactatc ctcccagagt ttctcgatga caaggacgag    11460

atcgcgctgg tgaactcctt taacgggttc acaaccgcgt ttaccggctt ctttgataac    11520

agggaaaata tgttctccga ggaggccaag tccaccagca tcgccttcag gtgtatcaac    11580

gagaacctca cccgctacat ttccaatatg gacattttcg agaaggtgga tgcgatcttc    11640

gataagcacg aggtgcagga gatcaaagag aagattctca attccgatta tgacgtcgag    11700

gatttcttcg aaggggagtt ctttaatttt gtgctcacac aagagggcat tgacgtgtac    11760

aacgcgatta tcgggggctt cgtcacagag tccggggaga agattaaggg gctgaatgag    11820

tacatcaatc tgtacaatca gaagaccaag cagaaactgc cgaaattcaa gccgctctac    11880

aagcaagtcc tgtccgatag ggaaagcctc tccttctacg gcgagggcta taccagcgac    11940

gaggaggtgc tggaagtctt ccgcaacaca ctgaataaga atagcgagat tttctcctcc    12000

atcaagaagc tcgagaagct ctttaagaac tttgacgagt acagctccgc cgggattttc    12060

gtgaagaacg ggccggcgat cagcaccatc tccaaggaca tctttggcga gtggaacgtc    12120

atcagggaca agtggaacgc cgagtacgac gacatccacc tgaagaagaa ggcggtggtg    12180

accgagaagt atgaggacga tcgcaggaag tccttcaaaa aaatcggctc cttcagcctc    12240

gaacagctcc aggagtatgc cgatgcggat ctgtccgtcg tcgagaagct gaaggaaatc    12300

atcattcaga aggtcgacga gatctataaa gtgtacgggt ccagcgagaa gctgttcgac    12360

gccgactttg tgctcgagaa gtccctcaaa aagaatgacg ccgtggtggc cattatgaaa    12420

gacctgctcg actccgtgaa gtccttcgaa aattacatta aagcgttctt tggggagggg    12480

aaggaaacta acagggatga gtccttctat ggcgactttg tcctcgcgta cgacatcctg    12540

ctgaaggtcg accacattta cgacgcgatc cgcaactacg tgacacagaa gccgtactcc    12600

aaagacaagt tcaagctgta cttccagaac ccgcaattta tggggggctg ggacaaggat    12660

aaagagacag actaccgcgc gacaattctc cgctatggct ccaaatacta tctggccatc    12720

atggacaaga agtacgcgaa gtgcctgcag aagatcgaca aagacgacgt caatggcaac    12780

tatgaaaaga tcaactacaa gctgctgccg ggcccgaaca agatgctccc gaaggtgttc    12840

ttcagcaaga agtggatggc ctactacaat ccaagcgagg atattcagaa aatctataaa    12900

aacgggacct tcaagaaggg ggacatgttt aacctcaacg actgccacaa gctcattgat    12960

ttcttcaagg atagcatttc ccgctacccg aaatggtcca atgcgtacga ttttaacttc    13020

tccgagacag aaaagtacaa agacatcgcg ggcttttaca gggaggtgga ggagcaaggg    13080

tataaagttt cttttgaatc cgcgagcaag aaggaagtcg acaagctcgt cgaggagggc    13140

aagctctaca tgttccaaat ttataacaag gacttttccg acaagagcca tgggacccca    13200

aacctccaca ccatgtactt caaactgctc tttgacgaga acaaccacgg gcaaatcagg    13260

ctgagcggcg gcgccgaatt attcatgcgc agggcctccc tcaagaagga agagctggtc    13320

gtccatccag ccaattcccc gatcgcgaac aagaacccgg acaatccgaa aaagaccacc    13380

accctgtcct acgacgtcta caaggacaaa cgcttcagcg aagaccagta cgaattacac    13440

atcccaattg cgattaataa gtgcccaaag aatatcttca aaattaatac agaggtcagg    13500

gtgctgctca aacacgacga caatccgtat gtcatcggca ttgacagggg cgagcgcaat    13560

ctgctctata tcgtggtcgt ggatgggaag ggcaatattg tggagcagta ctccctgaac    13620

gagattatca acaacttcaa tgggattagg attaagaccg actatcacag cctgctcgac    13680

aagaaagaaa aagagaggtt tgaggcccgc caaaactgga cctccattga gaatatcaaa    13740

gaattaaagg ccggctatat ttcccaagtc gtccacaaga tctgcgagct ggtggagaaa    13800

tatgacgccg tgattgcgct cgaagactta aattctgggt tcaagaactc ccgcgtgaag    13860

gtggaaaaac aggtgtatca gaaattcgag aaaatgctga tcgacaaact caattatatg    13920

gtggataaga agtccaaccc gtgtgccaca gggggcgcgc tgaagggcta tcagatcacc    13980

aacaagttcg agagcttcaa gagcatgagc acccagaacg ggtttatttt ctacatcccg    14040

gcgtggctca cctccaagat tgacccgagc accggcttcg tgaacctcct gaagacaaag    14100

tatacctcca ttgccgacag caagaagttt atctcctcct tcgaccgcat tatgtatgtg    14160

ccggaggagg acctcttcga gttcgccctc gactacaaaa acttcagccg cacagatgcg    14220

gattacatca agaagtggaa gctgtactcc tacgggaaca ggatccgcat cttcaggaat    14280

ccaaaaaaaa ataacgtctt tgactgggag gaagtgtgcc tgacatccgc ctacaaggaa    14340

ctgttcaata aatacggcat caattaccag cagggcgaca ttcgcgccct cctctgtgag    14400

cagtccgaca aagcgtttta ctccagcttc atggccctca tgtccctgat gctccaaatg    14460

aggaatagca tcacagggcg caccgacgtc gacttcctca tcagcccggt gaagaactcc    14520

gacgggatct tttacgactc ccgcaactat gaggcgcaag agaatgcgat cctcccgaag    14580

aacgccgatg cgaacggggc ctataatatc gccaggaaag tgctctgggc catcgggcag    14640

ttcaaaaagg cggaggatga gaagctcgac aaggtgaaaa ttgccatttc caacaaggag    14700

tggctggagt acgcgcagac ctccgtgaag cacggatcta agaagagaag aattaaacaa    14760

gattgactta attaaagggc tctctgtcat gatttcatac tttcattatt gagctctgta    14820

attacaatta tgaccatgag aacatctctt attgtgtggc cttttaattg ctgatgttag    14880

tactgaacca aagcttatcg tgatgatgta aaagcaataa gtacttgttt gtagcttctt    14940

tgtgtctccc tttgggctta atacatctgt ttagtgttgt ggctttggca tagacttctc    15000

ttggtaataa tgccttgcaa tgcaaaattt caattatcaa attctattat gttctcacct    15060

tatggtaaca gcttaccctg tggaagatga gattcttgag ttgagtcatt gccaattttt    15120

ggcattagct tttgaattag tgaattttga caaaaattac cgtgacactg attttgttga    15180

agctcttaag tgtagttttt acaaaatttc agtggctcgt tgtgattatg tcaaactcac    15240

ggcgaatgta gttcttacag aatttcagtg gctcgggccc ggccgtgacg gccacgagcg    15300

aactcctgca ggctcgaggt cattcatatg cttgagaaga gagtcgggat agtccaaaat    15360

aaaacaaagg taagattacc tggtcaaaag tgaaaacatc agttaaaagg tggtataaag    15420

taaaatatcg gtaataaaag gtggcccaaa gtgaaattta ctcttttcta ctattataaa    15480

aattgaggat gtttttgtcg gtactttgat acgtcatttt tgtatgaatt ggtttttaag    15540

tttattcgct tttggaaatg catatctgta tttgagtcgg gttttaagtt cgtttgcttt    15600

tgtaaataca gagggatttg tataagaaat atctttagaa aaacccatat gctaatttga    15660

cataattttt gagaaaaata tatattcagg cgaattctca caatgaacaa taataagatt    15720

aaaatagctt tcccccgttg cagcgcatgg gtattttttc tagtaaaaat aaaagataaa    15780

cttagactca aaacatttac aaaaacaacc cctaaagttc ctaaagccca aagtgctatc    15840

cacgatccat agcaagccca gcccaaccca acccaaccca acccacccca gtccagccaa    15900

ctggacaata gtctccacac ccccccacta tcaccgtgag ttgtccgcac gcaccgcacg    15960

tctcgcagcc aaaaaaaaaa agaaagaaaa aaaagaaaaa gaaaaaacag caggtgggtc    16020

cgggtcgtgg gggccggaaa cgcgaggagg atcgcgagcc agcgacgagg agcttaggcc    16080

tcatcgttga agatgcctct gccgacagtg gtcccaaaga tggaccccca cccacgagga    16140

gcatcgtgga aaaagaagac gttccaacca cgtcttcaaa gcaagtggat tgatgtgata    16200

tctccactga cgtaagggat gacgcacaat cccactatcc ttcgaggcct catcgttgaa    16260

gatgcctctg ccgacagtgg tcccaaagat ggacccccac ccacgaggag catcgtggaa    16320

aaagaagacg ttccaaccac gtcttcaaag caagtggatt gatgtgatat ctccactgac    16380

gtaagggatg acgcacaatc ccactatcct tcgaagctcc ctccctccgc ttccaaagaa    16440

acgcccccca tcgccactat atacataccc ccccctctcc tcccatcccc ccaacccttc    16500

tagaaccatc ttccacacac tcaagccaca ctattggaga acacacaggg acaacacacc    16560

ataagatcca agggaggcct ccgccgccgc cggtaaccac cccgcccctc tcctctttct    16620

ttctccgttt ttttttccgt ctcggtctcg atctttggcc ttggtagttt gggtgggcga    16680

gaggcggctt cgtgcgcgcc cagatcggtg cgcgggaggg gcgggatctc gcggctgggg    16740

ctctcgccgg cgtggatccg gcccggatct cgcggggaat ggggctctcg gatgtagatc    16800

tgcgatccgc cgttgttggg ggagatgatg gggggtttaa aatttccgcc gtgctaaaca    16860

agatcaggaa gaggggaaaa gggcactatg gtttatattt ttatatattt ctgctgcttc    16920

gtcaggctta gatgtgctag atctttcttt cttctttttg tgggtagaat ttgaatccct    16980

cagcattgtt catcggtagt ttttcttttc atgatttgtg acaaatgcag cctcgtgcgg    17040

agcttttttg taggtagaag gcggccgcat ggcccagtct aagcacgggt tgacgaagga    17100

gatgactatg aagtatcgca tggaaggctg cgttgacggc cacaaattcg tcattaccgg    17160

cgagggcatc ggctacccct ttaaggtaag tttctgcttc tacctttgat atatatataa    17220

taattatcat taattagtag taatataata tttcaaatat ttttttcaaa ataaaagaat    17280

gtagtatata gcaattgctt ttctgtagtt tataagtgtg tatattttaa tttataactt    17340

ttctaatata tgaccaaaat ttgttgatgt gcagggcaag caagcgataa acctgtgcgt    17400

ggtggagggt ggccctctgc ccttcgccga ggatatactc tcagccgcct tcatgtacgg    17460

gaatcgggtg ttcacggagt acccgcaaga catcgtggac tacttcaaga actcctgccc    17520

cgccggatac acatgggacc gttccttcct cttcgaggac ggagccgttt gcatctgcaa    17580

cgcggacatc accgtgtccg tcgaggagaa ctgcatgtac cacgagtcaa agttctatgg    17640

agtgaacttc ccggccgatg gtcccgtgat gaagaaaatg acggacaact gggagccgtc    17700

gtgcgagaaa atcattcccg tcccaaaaca gggaatcctc aagggcgacg tgtcgatgta    17760

cctacttctc aaggacggtg gacggctacg gtgccagttc gacactgttt acaaggcgaa    17820

gtcggtgccg aggaagatgc cggactggca ctttatccag cacaagctga caagggagga    17880

cagaagcgac gctaagaacc agaaatggca cctcaccgag cacgccatcg ccagtggctc    17940

tgcgctgccc gggtgaccct gcaatgtgac cctagacttg tccatcttct ggattggcca    18000

acttaattaa tgtatgaaat aaaaggatgc acacatagtg acatgctaat cactataatg    18060

tgggcatcaa agttgtgtgt tatgtgtaat tactaattat ctgaataaga gaaagagatc    18120

atccatattt cttatcctaa atgaatgtca cgtgtcttta taattctttg atgaaccaga    18180

tgcattttat taaccaattc catatacata taaatattaa tcatatataa ttaatatcaa    18240

ttgggttagc aaaacaaatc tagtctaggt gtgttttgct aattattggg ggatagtgca    18300

aaaagaaatc tacgttctca ataattcaga tagaaaactt aataaagtga gataatttac    18360

atagattgct tttatccttt gatatatgtg aaaccatgca tgatataagg aaaatagata    18420

gagaaataat tttttacatc gttgaatatg taaacaattt aattcaagaa gctaggaata    18480

taaatattga ggagtttatg attattatta ttattttgat gttcaatgaa gtttttttta    18540

atttcatatg aagtatacaa aaattcttca tagatttttg tttctatgcc gtagttatct    18600

ttaatatatt tgtggttgaa gaaatttatt gctagaaacg aatggattgt caattttttt    18660

ttaaagcaaa tatatatgaa attatactgt atattatttt agtcatgatt aaaatgtggc    18720

cttaattgaa tcatctttct cattcatttt ttcaaaagca tatcaggatg attgatattt    18780

atctatttta aaaattaatt taagggttca aattaaattt aacttaaaag tgtcctaacc    18840

gtagttaaag gtttacttta aaaaaatact atgaaaaatc taatcttcta tgaatcgagg    18900

gcccttagct agttag                                                    18916


<210>  84
<211>  18920
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3777 Full plasmid sequence

<400>  84
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt tgtaaccaac      480

atcccctgat gataatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggttggtgtg aaacagatga tttgctgctg taacaaagta     6240

aattatgtct cgacttttaa ggcccctttc attttattag attattttat tttaattaat     6300

gttcttgtcc cattttgcaa cagatggatg ctactacacc caagtattcc aaggccaggt     6360

atgatgaaat tgtgaaggaa gtctcttcct acttgaagaa agtaggatac aaccctgaca     6420

agattccttt tgttcctatc tctggttttg agggagacaa catgattgag aggtccacaa     6480

accttgactg gtacaagggt ccaactctgc ttgatgcact tgaccagatt agtgagccca     6540

agaggccctc tgacaagccc ctcaggcttc cccttcagga tgtgtacaag attggaggta     6600

ttggaactgt gccagtggga cgtgttgaga ccggtgtctt gaagcctgga atggtggtga     6660

cttttgcacc aactggactg acaactgaag tcaagtctgt ggagatgcac catgaatctc     6720

ttacagaggc acatcctggt gacaatgtgg gattcaatgt taagaatgtt gctgttaagg     6780

atttgaagcg tggttatgtt gcctcaaact caaaggatga ccctgcaaag gaggctgcta     6840

acttcacagc ccaagtcatc atcatgaacc accctggtca gattggaaat ggctatgccc     6900

ctgtcctcga ctgccacact tctcacattg ctgtcaagtt tgctgaactc atgaccaaga     6960

ttgacaggcg atccggcaaa gagcttgaga aggagcccaa gtttttgaag aacggtgatg     7020

ctggttttgt taagatgatt ccaaccaaac ccatggttgt tgaaactttc tccgagtatc     7080

ctccacttgg taggtttgct gttagggaca tgcgtcaaac tgttgctgtg ggagtcatca     7140

agaacgttga gaagaaggat cctaccggag ccaaggtcac caaggctgcc cagaagaaga     7200

agtcaaatgc tgctgatgaa gtggcaactc aattactgaa ttttgacctc ttgaagcttg     7260

ccggtgatgt tgagtctaac cctggaccaa tggcgcaagt tagcagaatc tgcaatggtg     7320

tgcagaaccc atctcttatc tccaatctct cgaaatccag tcaacgcaaa tctcccttat     7380

cggtttctct gaagacgcag cagcatccac gagcttatcc gatttcgtcg tcgtggggat     7440

tgaagaagag tgggatgacg ttaattggct ctgagcttcg tcctcttaag gtcatgtctt     7500

ctgtttccac ggcgtgcatg ggggaagcgg tgatcgccga agtatcgact caactatcag     7560

aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta catttgtacg     7620

gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg gttacggtga     7680

ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg gaaacttcgg     7740

cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt gtgcacgacg     7800

acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa tggcagcgca     7860

atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg gctatcttgc     7920

tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag gaactctttg     7980

atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg ctatggaact     8040

cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc cgcatttggt     8100

acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg gcaatggagc     8160

gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat cttggacaag     8220

aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac tacgtgaaag     8280

gcgagatcac caaggtagtc ggcaaatgaa tcgtgcgggc tggttcatca gggaatgttg     8340

gctacaatca atgttggttt cttttctgta ctcttgtgtc ttcttttcta ggtagcttgt     8400

ttttcggaca aagtttgaag tctccaccat catctcgcaa ctgttgttcc cagaactggg     8460

ttcttgatcg acggtggcaa aattgctttt atttatctgt gttttaatgt gttgtgtttg     8520

tcggaacccc tgattacatt tttgttaagc gcagcgagtt tcaggacttt gctgcgttgt     8580

gttgctttgg tttattaaat gtcaactttc tatttgtagt gttcaatttt tggcttggtt     8640

tgctttttct ttataatttg tgttcaaatt ttggcttggt ttgcttttac tataatttgt     8700

gttcaaattt tgggttggat tttttaacga tcggctgttt gctcttcttc ctctgttttg     8760

atgtgttcgt gactatgcaa gaatcttcaa ttttgctaaa ataaacttgc tttgacaaca     8820

tagaatcaaa tccgagtgct ttaatattcg gtggtttgtt tttatttttg gttttatgaa     8880

agttaaaatt ttaaaagtaa atcgataagg tataattgtg gtttttattt atcgagaatt     8940

ttttaagtga atcgatataa tttatttccc ctaaaataaa ataccaaaga atcgaattcg     9000

aactttgtct ttaataaaac tactaattta atcattattt gttctgtgta agcatgagaa     9060

ataaattcta cttatctttt agtttaaaac caaaacaggt taagaataat ttttctaagg     9120

ccgttatcaa ggtcaccaaa aatctattcg atctgaccat atattttcga tacttgtacg     9180

attcgcagat gttgattgga aattgcaatg aataaattac aaatgccaaa tccgattatg     9240

caatgaatga attacaagtg catttatccg ttttgaatct gttcatgtct accaatggga     9300

gagatttttt tcctgcatct gccatacata tgggaagacc gaaaatactt tcctaggctg     9360

gcagcacatc ccccgttcgc gagctggcgt aacagcgaag aggcccgggc gcgccactgt     9420

taataatttt taaacgtcag cgcactaaaa aaacgaaaag acggacacgt gaaaataaaa     9480

aacacacact agtttatgac gcaatactat tttacttatg atttgggtac attagacaaa     9540

accgtgaaag agatgtatca gctatgaaac ctgtatactt caatacagag acttactcat     9600

atcggatacg tacgcacgaa gtatcatatt aattatttta atttttaata aatattttat     9660

cggatactta tgtgatactc tacatataca caaggatatt tctaagatac tttatagata     9720

cgtatcctag aaaaacatga agagtaaaaa agtgagacaa tgttgtaaaa attcattata     9780

aatgtatatg attcaatttt agatatgcat cagtataatt gattctcgat gaaacactta     9840

aaattatatt tcttgtggaa gaacgtagcg agagaggtga ttcagttaga caacattaaa     9900

taaaattaat gttaagttct tttaatgatg tttctctcaa tatcacatca tatgaaaatg     9960

taatatgatt tataagaaaa tttttaaaaa atttatttta ataatcacat gtactatttt    10020

ttaaaaattg tatcttttat aataatacaa taataaagag taatcagtgt taatttttct    10080

tcaaatataa gttttattat aaatcattgt taacgtatca taagtcatta ccgtatcgta    10140

tcttaatttt tttttaaaaa ccgctaattc acgtacccgt attgtattgt acccgcacct    10200

gtatcacaat cgatcttagt tagaagaatt gtctcgaggc ggtgcaagac agcatataat    10260

agacgtggac tctcttatac caaacgttgt cgtatcacaa agggttaggt aacaagtcac    10320

agtttgtcca cgtgtcacgt tttaattgga agaggtgccg ttggcgtaat ataacagcca    10380

atcgattttt gctataaaag caaatcaggt aaactaaact tcttcattct tttcttcccc    10440

atcgctacaa aaccggttcc tttggaaaag agattcattc aaacctagca cccaattccg    10500

tttcaaggta taatctactt tctattcttc gattatttta ttattattag ctactatcgt    10560

ttaatcgatc ttttcttttg atccgtcaaa tttaaattca attagggttt tgttcttttc    10620

tttcatctga ttgaaatcct tctgaattga accgtttact tgattttact gtttattgta    10680

tgatttaatc ctttgttttt caaagacagt ctttagattg tgattagggg ttcatataaa    10740

tttttagatt tggatttttg tattgtatga ttcaaaaaat acgtccttta attagattag    10800

tacatggata ttttttaccc gatttattga ttgtcaggga gaatttgatg agcaagtttt    10860

tttgatgtct gttgtaaatt gaattgatta taattgctga tctgctgctt ccagttttca    10920

taacccatat tcttttaacc ttgttgtaca cacaatgaaa aattggtgat tgattcattt    10980

gtttttcttt gttttggatt atacagggtg gtaccaaaaa atggcgggat ctaagaagag    11040

aagaattaaa caagattcca agctggagaa gtttacaaac tgttacagcc tctccaaaac    11100

cctcaggttt aaagcgatcc cggtgggcaa gacccaggag aacatcgaca acaagaggct    11160

cctggtggaa gacgagaagc gcgccgaaga ctacaagggc gtgaagaagc tgctcgatag    11220

gtactacctc agctttatta acgacgtgct gcacagcatc aaactcaaga atctcaacaa    11280

ctacatctcc ctcttccgca aaaagacccg caccgagaag gagaacaagg agctggagaa    11340

cctggagatc aacctccgca aggaaatcgc caaagcgttc aagggcaatg aagggtacaa    11400

gagcctcttc aagaaagaca tcatcgaaac tatcctccca gagtttctcg atgacaagga    11460

cgagatcgcg ctggtgaact cctttaacgg gttcacaacc gcgtttaccg gcttctttga    11520

taacagggaa aatatgttct ccgaggaggc caagtccacc agcatcgcct tcaggtgtat    11580

caacgagaac ctcacccgct acatttccaa tatggacatt ttcgagaagg tggatgcgat    11640

cttcgataag cacgaggtgc aggagatcaa agagaagatt ctcaattccg attatgacgt    11700

cgaggatttc ttcgaagggg agttctttaa ttttgtgctc acacaagagg gcattgacgt    11760

gtacaacgcg attatcgggg gcttcgtcac agagtccggg gagaagatta aggggctgaa    11820

tgagtacatc aatctgtaca atcagaagac caagcagaaa ctgccgaaat tcaagccgct    11880

ctacaagcaa gtcctgtccg atagggaaag cctctccttc tacggcgagg gctataccag    11940

cgacgaggag gtgctggaag tcttccgcaa cacactgaat aagaatagcg agattttctc    12000

ctccatcaag aagctcgaga agctctttaa gaactttgac gagtacagct ccgccgggat    12060

tttcgtgaag aacgggccgg cgatcagcac catctccaag gacatctttg gcgagtggaa    12120

cgtcatcagg gacaagtgga acgccgagta cgacgacatc cacctgaaga agaaggcggt    12180

ggtgaccgag aagtatgagg acgatcgcag gaagtccttc aaaaaaatcg gctccttcag    12240

cctcgaacag ctccaggagt atgccgatgc ggatctgtcc gtcgtcgaga agctgaagga    12300

aatcatcatt cagaaggtcg acgagatcta taaagtgtac gggtccagcg agaagctgtt    12360

cgacgccgac tttgtgctcg agaagtccct caaaaagaat gacgccgtgg tggccattat    12420

gaaagacctg ctcgactccg tgaagtcctt cgaaaattac attaaagcgt tctttgggga    12480

ggggaaggaa actaacaggg atgagtcctt ctatggcgac tttgtcctcg cgtacgacat    12540

cctgctgaag gtcgaccaca tttacgacgc gatccgcaac tacgtgacac agaagccgta    12600

ctccaaagac aagttcaagc tgtacttcca gaacccgcaa tttatggggg gctgggacaa    12660

ggataaagag acagactacc gcgcgacaat tctccgctat ggctccaaat actatctggc    12720

catcatggac aagaagtacg cgaagtgcct gcagaagatc gacaaagacg acgtcaatgg    12780

caactatgaa aagatcaact acaagctgct gccgggcccg aacaagatgc tcccgaaggt    12840

gttcttcagc aagaagtgga tggcctacta caatccaagc gaggatattc agaaaatcta    12900

taaaaacggg accttcaaga agggggacat gtttaacctc aacgactgcc acaagctcat    12960

tgatttcttc aaggatagca tttcccgcta cccgaaatgg tccaatgcgt acgattttaa    13020

cttctccgag acagaaaagt acaaagacat cgcgggcttt tacagggagg tggaggagca    13080

agggtataaa gtttcttttg aatccgcgag caagaaggaa gtcgacaagc tcgtcgagga    13140

gggcaagctc tacatgttcc aaatttataa caaggacttt tccgacaaga gccatgggac    13200

cccaaacctc cacaccatgt acttcaaact gctctttgac gagaacaacc acgggcaaat    13260

caggctgagc ggcggcgccg aattattcat gcgcagggcc tccctcaaga aggaagagct    13320

ggtcgtccat ccagccaatt ccccgatcgc gaacaagaac ccggacaatc cgaaaaagac    13380

caccaccctg tcctacgacg tctacaagga caaacgcttc agcgaagacc agtacgaatt    13440

acacatccca attgcgatta ataagtgccc aaagaatatc ttcaaaatta atacagaggt    13500

cagggtgctg ctcaaacacg acgacaatcc gtatgtcatc ggcattgaca ggggcgagcg    13560

caatctgctc tatatcgtgg tcgtggatgg gaagggcaat attgtggagc agtactccct    13620

gaacgagatt atcaacaact tcaatgggat taggattaag accgactatc acagcctgct    13680

cgacaagaaa gaaaaagaga ggtttgaggc ccgccaaaac tggacctcca ttgagaatat    13740

caaagaatta aaggccggct atatttccca agtcgtccac aagatctgcg agctggtgga    13800

gaaatatgac gccgtgattg cgctcgaaga cttaaattct gggttcaaga actcccgcgt    13860

gaaggtggaa aaacaggtgt atcagaaatt cgagaaaatg ctgatcgaca aactcaatta    13920

tatggtggat aagaagtcca acccgtgtgc cacagggggc gcgctgaagg gctatcagat    13980

caccaacaag ttcgagagct tcaagagcat gagcacccag aacgggttta ttttctacat    14040

cccggcgtgg ctcacctcca agattgaccc gagcaccggc ttcgtgaacc tcctgaagac    14100

aaagtatacc tccattgccg acagcaagaa gtttatctcc tccttcgacc gcattatgta    14160

tgtgccggag gaggacctct tcgagttcgc cctcgactac aaaaacttca gccgcacaga    14220

tgcggattac atcaagaagt ggaagctgta ctcctacggg aacaggatcc gcatcttcag    14280

gaatccaaaa aaaaataacg tctttgactg ggaggaagtg tgcctgacat ccgcctacaa    14340

ggaactgttc aataaatacg gcatcaatta ccagcagggc gacattcgcg ccctcctctg    14400

tgagcagtcc gacaaagcgt tttactccag cttcatggcc ctcatgtccc tgatgctcca    14460

aatgaggaat agcatcacag ggcgcaccga cgtcgacttc ctcatcagcc cggtgaagaa    14520

ctccgacggg atcttttacg actcccgcaa ctatgaggcg caagagaatg cgatcctccc    14580

gaagaacgcc gatgcgaacg gggcctataa tatcgccagg aaagtgctct gggccatcgg    14640

gcagttcaaa aaggcggagg atgagaagct cgacaaggtg aaaattgcca tttccaacaa    14700

ggagtggctg gagtacgcgc agacctccgt gaagcacgga tctaagaaga gaagaattaa    14760

acaagattga cttaattaaa gggctctctg tcatgatttc atactttcat tattgagctc    14820

tgtaattaca attatgacca tgagaacatc tcttattgtg tggcctttta attgctgatg    14880

ttagtactga accaaagctt atcgtgatga tgtaaaagca ataagtactt gtttgtagct    14940

tctttgtgtc tccctttggg cttaatacat ctgtttagtg ttgtggcttt ggcatagact    15000

tctcttggta ataatgcctt gcaatgcaaa atttcaatta tcaaattcta ttatgttctc    15060

accttatggt aacagcttac cctgtggaag atgagattct tgagttgagt cattgccaat    15120

ttttggcatt agcttttgaa ttagtgaatt ttgacaaaaa ttaccgtgac actgattttg    15180

ttgaagctct taagtgtagt ttttacaaaa tttcagtggc tcgttgtgat tatgtcaaac    15240

tcacggcgaa tgtagttctt acagaatttc agtggctcgg gcccggccgt gacggccacg    15300

agcgaactcc tgcaggctcg aggtcattca tatgcttgag aagagagtcg ggatagtcca    15360

aaataaaaca aaggtaagat tacctggtca aaagtgaaaa catcagttaa aaggtggtat    15420

aaagtaaaat atcggtaata aaaggtggcc caaagtgaaa tttactcttt tctactatta    15480

taaaaattga ggatgttttt gtcggtactt tgatacgtca tttttgtatg aattggtttt    15540

taagtttatt cgcttttgga aatgcatatc tgtatttgag tcgggtttta agttcgtttg    15600

cttttgtaaa tacagaggga tttgtataag aaatatcttt agaaaaaccc atatgctaat    15660

ttgacataat ttttgagaaa aatatatatt caggcgaatt ctcacaatga acaataataa    15720

gattaaaata gctttccccc gttgcagcgc atgggtattt tttctagtaa aaataaaaga    15780

taaacttaga ctcaaaacat ttacaaaaac aacccctaaa gttcctaaag cccaaagtgc    15840

tatccacgat ccatagcaag cccagcccaa cccaacccaa cccaacccac cccagtccag    15900

ccaactggac aatagtctcc acaccccccc actatcaccg tgagttgtcc gcacgcaccg    15960

cacgtctcgc agccaaaaaa aaaaagaaag aaaaaaaaga aaaagaaaaa acagcaggtg    16020

ggtccgggtc gtgggggccg gaaacgcgag gaggatcgcg agccagcgac gaggagctta    16080

ggcctcatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc cccacccacg    16140

aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt ggattgatgt    16200

gatatctcca ctgacgtaag ggatgacgca caatcccact atccttcgag gcctcatcgt    16260

tgaagatgcc tctgccgaca gtggtcccaa agatggaccc ccacccacga ggagcatcgt    16320

ggaaaaagaa gacgttccaa ccacgtcttc aaagcaagtg gattgatgtg atatctccac    16380

tgacgtaagg gatgacgcac aatcccacta tccttcgaag ctccctccct ccgcttccaa    16440

agaaacgccc cccatcgcca ctatatacat acccccccct ctcctcccat ccccccaacc    16500

cttctagaac catcttccac acactcaagc cacactattg gagaacacac agggacaaca    16560

caccataaga tccaagggag gcctccgccg ccgccggtaa ccaccccgcc cctctcctct    16620

ttctttctcc gttttttttt ccgtctcggt ctcgatcttt ggccttggta gtttgggtgg    16680

gcgagaggcg gcttcgtgcg cgcccagatc ggtgcgcggg aggggcggga tctcgcggct    16740

ggggctctcg ccggcgtgga tccggcccgg atctcgcggg gaatggggct ctcggatgta    16800

gatctgcgat ccgccgttgt tgggggagat gatggggggt ttaaaatttc cgccgtgcta    16860

aacaagatca ggaagagggg aaaagggcac tatggtttat atttttatat atttctgctg    16920

cttcgtcagg cttagatgtg ctagatcttt ctttcttctt tttgtgggta gaatttgaat    16980

ccctcagcat tgttcatcgg tagtttttct tttcatgatt tgtgacaaat gcagcctcgt    17040

gcggagcttt tttgtaggta gaaggcggcc gcatggccca gtctaagcac gggttgacga    17100

aggagatgac tatgaagtat cgcatggaag gctgcgttga cggccacaaa ttcgtcatta    17160

ccggcgaggg catcggctac ccctttaagg taagtttctg cttctacctt tgatatatat    17220

ataataatta tcattaatta gtagtaatat aatatttcaa atattttttt caaaataaaa    17280

gaatgtagta tatagcaatt gcttttctgt agtttataag tgtgtatatt ttaatttata    17340

acttttctaa tatatgacca aaatttgttg atgtgcaggg caagcaagcg ataaacctgt    17400

gcgtggtgga gggtggccct ctgcccttcg ccgaggatat actctcagcc gccttcatgt    17460

acgggaatcg ggtgttcacg gagtacccgc aagacatcgt ggactacttc aagaactcct    17520

gccccgccgg atacacatgg gaccgttcct tcctcttcga ggacggagcc gtttgcatct    17580

gcaacgcgga catcaccgtg tccgtcgagg agaactgcat gtaccacgag tcaaagttct    17640

atggagtgaa cttcccggcc gatggtcccg tgatgaagaa aatgacggac aactgggagc    17700

cgtcgtgcga gaaaatcatt cccgtcccaa aacagggaat cctcaagggc gacgtgtcga    17760

tgtacctact tctcaaggac ggtggacggc tacggtgcca gttcgacact gtttacaagg    17820

cgaagtcggt gccgaggaag atgccggact ggcactttat ccagcacaag ctgacaaggg    17880

aggacagaag cgacgctaag aaccagaaat ggcacctcac cgagcacgcc atcgccagtg    17940

gctctgcgct gcccgggtga ccctgcaatg tgaccctaga cttgtccatc ttctggattg    18000

gccaacttaa ttaatgtatg aaataaaagg atgcacacat agtgacatgc taatcactat    18060

aatgtgggca tcaaagttgt gtgttatgtg taattactaa ttatctgaat aagagaaaga    18120

gatcatccat atttcttatc ctaaatgaat gtcacgtgtc tttataattc tttgatgaac    18180

cagatgcatt ttattaacca attccatata catataaata ttaatcatat ataattaata    18240

tcaattgggt tagcaaaaca aatctagtct aggtgtgttt tgctaattat tgggggatag    18300

tgcaaaaaga aatctacgtt ctcaataatt cagatagaaa acttaataaa gtgagataat    18360

ttacatagat tgcttttatc ctttgatata tgtgaaacca tgcatgatat aaggaaaata    18420

gatagagaaa taatttttta catcgttgaa tatgtaaaca atttaattca agaagctagg    18480

aatataaata ttgaggagtt tatgattatt attattattt tgatgttcaa tgaagttttt    18540

tttaatttca tatgaagtat acaaaaattc ttcatagatt tttgtttcta tgccgtagtt    18600

atctttaata tatttgtggt tgaagaaatt tattgctaga aacgaatgga ttgtcaattt    18660

ttttttaaag caaatatata tgaaattata ctgtatatta ttttagtcat gattaaaatg    18720

tggccttaat tgaatcatct ttctcattca ttttttcaaa agcatatcag gatgattgat    18780

atttatctat tttaaaaatt aatttaaggg ttcaaattaa atttaactta aaagtgtcct    18840

aaccgtagtt aaaggtttac tttaaaaaaa tactatgaaa aatctaatct tctatgaatc    18900

gagggccctt agctagttag                                                18920


<210>  85
<211>  12883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3387 Full plasmid sequence

<400>  85
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctaaaaga ttgacacatt gcctatacta cattctagcg taggttaaat     8160

ttatatcaga taatgtggga gaaagagatc agttaccatt gcatgacaat agctgacccc     8220

agatatgagt tgttgaaaga agaaacgagc ctgtggcatg acaatgggtt aatagttaca     8280

caggaaatag agagctagca caagcaaaag taaacaaatt gtataagaac ctcatcctca     8340

ttaaaacgcc ctgcattgca gattttctca aatagttctc caccagatgc atattccatt     8400

acaatgtcta gatgagtcgg tgttagaata acctgagtca aatatcaaag aacattttcc     8460

atgaatatga ttattgtacc tctgaacata aaaatatata aatacaaata tataccaacc     8520

tccttaaacc tgataatgtt aggatgtctt agagacctgt gattaatgat ttctctttta     8580

acattttcat caatctgtga cacacagcaa atgatagggg gcgcgcctag ctaactagct     8640

agccacgtga ctcgcagaac gttgtgtggc gagacggaaa gaaagtcacg cctccaaaga     8700

gtgcagcatc tcttctggct ctcacggtcc tctgtggatc catcgatatc gaattcctgc     8760

aggctcgagg tcattcatat gcttgagaag agagtcggga tagtccaaaa taaaacaaag     8820

gtaagattac ctggtcaaaa gtgaaaacat cagttaaaag gtggtataaa gtaaaatatc     8880

ggtaataaaa ggtggcccaa agtgaaattt actcttttct actattataa aaattgagga     8940

tgtttttgtc ggtactttga tacgtcattt ttgtatgaat tggtttttaa gtttattcgc     9000

ttttggaaat gcatatctgt atttgagtcg ggttttaagt tcgtttgctt ttgtaaatac     9060

agagggattt gtataagaaa tatctttaga aaaacccata tgctaatttg acataatttt     9120

tgagaaaaat atatattcag gcgaattctc acaatgaaca ataataagat taaaatagct     9180

ttcccccgtt gcagcgcatg ggtatttttt ctagtaaaaa taaaagataa acttagactc     9240

aaaacattta caaaaacaac ccctaaagtt cctaaagccc aaagtgctat ccacgatcca     9300

tagcaagccc agcccaaccc aacccaaccc aacccacccc agtccagcca actggacaat     9360

agtctccaca cccccccact atcaccgtga gttgtccgca cgcaccgcac gtctcgcagc     9420

caaaaaaaaa aagaaagaaa aaaaagaaaa agaaaaaaca gcaggtgggt ccgggtcgtg     9480

ggggccggaa acgcgaggag gatcgcgagc cagcgacgag gagcttaggc ctcatcgttg     9540

aagatgcctc tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg     9600

aaaaagaaga cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg     9660

acgtaaggga tgacgcacaa tcccactatc cttcgaggcc tcatcgttga agatgcctct     9720

gccgacagtg gtcccaaaga tggaccccca cccacgagga gcatcgtgga aaaagaagac     9780

gttccaacca cgtcttcaaa gcaagtggat tgatgtgata tctccactga cgtaagggat     9840

gacgcacaat cccactatcc ttcgaagctc cctccctccg cttccaaaga aacgcccccc     9900

atcgccacta tatacatacc cccccctctc ctcccatccc cccaaccctt ctagaaccat     9960

cttccacaca ctcaagccac actattggag aacacacagg gacaacacac cataagatcc    10020

aagggaggcc tccgccgccg ccggtaacca ccccgcccct ctcctctttc tttctccgtt    10080

tttttttccg tctcggtctc gatctttggc cttggtagtt tgggtgggcg agaggcggct    10140

tcgtgcgcgc ccagatcggt gcgcgggagg ggcgggatct cgcggctggg gctctcgccg    10200

gcgtggatcc ggcccggatc tcgcggggaa tggggctctc ggatgtagat ctgcgatccg    10260

ccgttgttgg gggagatgat ggggggttta aaatttccgc cgtgctaaac aagatcagga    10320

agaggggaaa agggcactat ggtttatatt tttatatatt tctgctgctt cgtcaggctt    10380

agatgtgcta gatctttctt tcttcttttt gtgggtagaa tttgaatccc tcagcattgt    10440

tcatcggtag tttttctttt catgatttgt gacaaatgca gcctcgtgcg gagctttttt    10500

gtaggtagaa ggcggccgca tggcccagtc taagcacggg ttgacgaagg agatgactat    10560

gaagtatcgc atggaaggct gcgttgacgg ccacaaattc gtcattaccg gcgagggcat    10620

cggctacccc tttaaggtaa gtttctgctt ctacctttga tatatatata ataattatca    10680

ttaattagta gtaatataat atttcaaata tttttttcaa aataaaagaa tgtagtatat    10740

agcaattgct tttctgtagt ttataagtgt gtatatttta atttataact tttctaatat    10800

atgaccaaaa tttgttgatg tgcagggcaa gcaagcgata aacctgtgcg tggtggaggg    10860

tggccctctg cccttcgccg aggatatact ctcagccgcc ttcatgtacg ggaatcgggt    10920

gttcacggag tacccgcaag acatcgtgga ctacttcaag aactcctgcc ccgccggata    10980

cacatgggac cgttccttcc tcttcgagga cggagccgtt tgcatctgca acgcggacat    11040

caccgtgtcc gtcgaggaga actgcatgta ccacgagtca aagttctatg gagtgaactt    11100

cccggccgat ggtcccgtga tgaagaaaat gacggacaac tgggagccgt cgtgcgagaa    11160

aatcattccc gtcccaaaac agggaatcct caagggcgac gtgtcgatgt acctacttct    11220

caaggacggt ggacggctac ggtgccagtt cgacactgtt tacaaggcga agtcggtgcc    11280

gaggaagatg ccggactggc actttatcca gcacaagctg acaagggagg acagaagcga    11340

cgctaagaac cagaaatggc acctcaccga gcacgccatc gccagtggct ctgcgctgcc    11400

cgggtgaccc tgcaatgtga ccctagactt gtccatcttc tggattggcc aacttaatta    11460

atgtatgaaa taaaaggatg cacacatagt gacatgctaa tcactataat gtgggcatca    11520

aagttgtgtg ttatgtgtaa ttactaatta tctgaataag agaaagagat catccatatt    11580

tcttatccta aatgaatgtc acgtgtcttt ataattcttt gatgaaccag atgcatttta    11640

ttaaccaatt ccatatacat ataaatatta atcatatata attaatatca attgggttag    11700

caaaacaaat ctagtctagg tgtgttttgc taattattgg gggatagtgc aaaaagaaat    11760

ctacgttctc aataattcag atagaaaact taataaagtg agataattta catagattgc    11820

ttttatcctt tgatatatgt gaaaccatgc atgatataag gaaaatagat agagaaataa    11880

ttttttacat cgttgaatat gtaaacaatt taattcaaga agctaggaat ataaatattg    11940

aggagtttat gattattatt attattttga tgttcaatga agtttttttt aatttcatat    12000

gaagtataca aaaattcttc atagattttt gtttctatgc cgtagttatc tttaatatat    12060

ttgtggttga agaaatttat tgctagaaac gaatggattg tcaatttttt tttaaagcaa    12120

atatatatga aattatactg tatattattt tagtcatgat taaaatgtgg ccttaattga    12180

atcatctttc tcattcattt tttcaaaagc atatcaggat gattgatatt tatctatttt    12240

aaaaattaat ttaagggttc aaattaaatt taacttaaaa gtgtcctaac cgtagttaaa    12300

ggtttacttt aaaaaaatac tatgaaaaat ctaatcttct atgaatcgag ggcccttagc    12360

tagttagacg ataaaaatgt tttaaacgat atatattata aaaaaaaacg tttcaaaaat    12420

aaatacaaaa atgtttttaa atatatataa tttaactcat taaagaaaat aaaaatgcaa    12480

gtgcggtgac aagacaagct aaaagttgca aaagaaatgg cagggctata aggctcacct    12540

actcctggat ttaccaaatt ttggttcgtc cctatactcg aaaaataaaa caaaataaat    12600

ttcagtatct tcgtttttgt atgctttgac tgtgaggcga ggccaacttt cttcttctgt    12660

ctgagatgaa ttttgtttgc ctcctgtgaa ggatgtatca ttcaaagtga atgttttgca    12720

actgccagta gtcccacatc gaccaaatat tcttattaca gtgtgtttat atagcacctg    12780

gagaaggaat gggttgtttc aaagattaaa taatttctac taagtgtaga tacacctact    12840

catctggcca ttgttaattt ctactaagtg tagatttttt tta                      12883


<210>  86
<211>  12883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3388 Full plasmid sequence

<400>  86
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctccctat catttgctgt gtgtcacaga ttgatgaaaa tgttaaaaga     8160

gaaatcatta atcacaggtc tctaagacat cctaacatta tcaggtttaa ggaggttggt     8220

atatatttgt atttatatat ttttatgttc agaggtacaa taatcatatt catggaaaat     8280

gttctttgat atttgactca ggttattcta acaccgactc atctagacat tgtaatggaa     8340

tatgcatctg gtggagaact atttgagaaa atctgcaatg cagggcgttt taatgaggat     8400

gaggttctta tacaatttgt ttacttttgc ttgtgctagc tctctatttc ctgtgtaact     8460

attaacccat tgtcatgcca caggctcgtt tcttctttca acaactcata tctggggtca     8520

gctattgtca tgcaatggta actgatctct ttctcccaca ttatctgata taaatttaac     8580

ctacgctaga atgtagtata ggcaatgtgt caatcttttg gcgcgcctag ctaactagct     8640

agccacgtga ctcgcagaac gttgtgtggc gagacggaaa gaaagtcacg cctccaaaga     8700

gtgcagcatc tcttctggct ctcacggtcc tctgtggatc catcgatatc gaattcctgc     8760

aggctcgagg tcattcatat gcttgagaag agagtcggga tagtccaaaa taaaacaaag     8820

gtaagattac ctggtcaaaa gtgaaaacat cagttaaaag gtggtataaa gtaaaatatc     8880

ggtaataaaa ggtggcccaa agtgaaattt actcttttct actattataa aaattgagga     8940

tgtttttgtc ggtactttga tacgtcattt ttgtatgaat tggtttttaa gtttattcgc     9000

ttttggaaat gcatatctgt atttgagtcg ggttttaagt tcgtttgctt ttgtaaatac     9060

agagggattt gtataagaaa tatctttaga aaaacccata tgctaatttg acataatttt     9120

tgagaaaaat atatattcag gcgaattctc acaatgaaca ataataagat taaaatagct     9180

ttcccccgtt gcagcgcatg ggtatttttt ctagtaaaaa taaaagataa acttagactc     9240

aaaacattta caaaaacaac ccctaaagtt cctaaagccc aaagtgctat ccacgatcca     9300

tagcaagccc agcccaaccc aacccaaccc aacccacccc agtccagcca actggacaat     9360

agtctccaca cccccccact atcaccgtga gttgtccgca cgcaccgcac gtctcgcagc     9420

caaaaaaaaa aagaaagaaa aaaaagaaaa agaaaaaaca gcaggtgggt ccgggtcgtg     9480

ggggccggaa acgcgaggag gatcgcgagc cagcgacgag gagcttaggc ctcatcgttg     9540

aagatgcctc tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg     9600

aaaaagaaga cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg     9660

acgtaaggga tgacgcacaa tcccactatc cttcgaggcc tcatcgttga agatgcctct     9720

gccgacagtg gtcccaaaga tggaccccca cccacgagga gcatcgtgga aaaagaagac     9780

gttccaacca cgtcttcaaa gcaagtggat tgatgtgata tctccactga cgtaagggat     9840

gacgcacaat cccactatcc ttcgaagctc cctccctccg cttccaaaga aacgcccccc     9900

atcgccacta tatacatacc cccccctctc ctcccatccc cccaaccctt ctagaaccat     9960

cttccacaca ctcaagccac actattggag aacacacagg gacaacacac cataagatcc    10020

aagggaggcc tccgccgccg ccggtaacca ccccgcccct ctcctctttc tttctccgtt    10080

tttttttccg tctcggtctc gatctttggc cttggtagtt tgggtgggcg agaggcggct    10140

tcgtgcgcgc ccagatcggt gcgcgggagg ggcgggatct cgcggctggg gctctcgccg    10200

gcgtggatcc ggcccggatc tcgcggggaa tggggctctc ggatgtagat ctgcgatccg    10260

ccgttgttgg gggagatgat ggggggttta aaatttccgc cgtgctaaac aagatcagga    10320

agaggggaaa agggcactat ggtttatatt tttatatatt tctgctgctt cgtcaggctt    10380

agatgtgcta gatctttctt tcttcttttt gtgggtagaa tttgaatccc tcagcattgt    10440

tcatcggtag tttttctttt catgatttgt gacaaatgca gcctcgtgcg gagctttttt    10500

gtaggtagaa ggcggccgca tggcccagtc taagcacggg ttgacgaagg agatgactat    10560

gaagtatcgc atggaaggct gcgttgacgg ccacaaattc gtcattaccg gcgagggcat    10620

cggctacccc tttaaggtaa gtttctgctt ctacctttga tatatatata ataattatca    10680

ttaattagta gtaatataat atttcaaata tttttttcaa aataaaagaa tgtagtatat    10740

agcaattgct tttctgtagt ttataagtgt gtatatttta atttataact tttctaatat    10800

atgaccaaaa tttgttgatg tgcagggcaa gcaagcgata aacctgtgcg tggtggaggg    10860

tggccctctg cccttcgccg aggatatact ctcagccgcc ttcatgtacg ggaatcgggt    10920

gttcacggag tacccgcaag acatcgtgga ctacttcaag aactcctgcc ccgccggata    10980

cacatgggac cgttccttcc tcttcgagga cggagccgtt tgcatctgca acgcggacat    11040

caccgtgtcc gtcgaggaga actgcatgta ccacgagtca aagttctatg gagtgaactt    11100

cccggccgat ggtcccgtga tgaagaaaat gacggacaac tgggagccgt cgtgcgagaa    11160

aatcattccc gtcccaaaac agggaatcct caagggcgac gtgtcgatgt acctacttct    11220

caaggacggt ggacggctac ggtgccagtt cgacactgtt tacaaggcga agtcggtgcc    11280

gaggaagatg ccggactggc actttatcca gcacaagctg acaagggagg acagaagcga    11340

cgctaagaac cagaaatggc acctcaccga gcacgccatc gccagtggct ctgcgctgcc    11400

cgggtgaccc tgcaatgtga ccctagactt gtccatcttc tggattggcc aacttaatta    11460

atgtatgaaa taaaaggatg cacacatagt gacatgctaa tcactataat gtgggcatca    11520

aagttgtgtg ttatgtgtaa ttactaatta tctgaataag agaaagagat catccatatt    11580

tcttatccta aatgaatgtc acgtgtcttt ataattcttt gatgaaccag atgcatttta    11640

ttaaccaatt ccatatacat ataaatatta atcatatata attaatatca attgggttag    11700

caaaacaaat ctagtctagg tgtgttttgc taattattgg gggatagtgc aaaaagaaat    11760

ctacgttctc aataattcag atagaaaact taataaagtg agataattta catagattgc    11820

ttttatcctt tgatatatgt gaaaccatgc atgatataag gaaaatagat agagaaataa    11880

ttttttacat cgttgaatat gtaaacaatt taattcaaga agctaggaat ataaatattg    11940

aggagtttat gattattatt attattttga tgttcaatga agtttttttt aatttcatat    12000

gaagtataca aaaattcttc atagattttt gtttctatgc cgtagttatc tttaatatat    12060

ttgtggttga agaaatttat tgctagaaac gaatggattg tcaatttttt tttaaagcaa    12120

atatatatga aattatactg tatattattt tagtcatgat taaaatgtgg ccttaattga    12180

atcatctttc tcattcattt tttcaaaagc atatcaggat gattgatatt tatctatttt    12240

aaaaattaat ttaagggttc aaattaaatt taacttaaaa gtgtcctaac cgtagttaaa    12300

ggtttacttt aaaaaaatac tatgaaaaat ctaatcttct atgaatcgag ggcccttagc    12360

tagttagacg ataaaaatgt tttaaacgat atatattata aaaaaaaacg tttcaaaaat    12420

aaatacaaaa atgtttttaa atatatataa tttaactcat taaagaaaat aaaaatgcaa    12480

gtgcggtgac aagacaagct aaaagttgca aaagaaatgg cagggctata aggctcacct    12540

actcctggat ttaccaaatt ttggttcgtc cctatactcg aaaaataaaa caaaataaat    12600

ttcagtatct tcgtttttgt atgctttgac tgtgaggcga ggccaacttt cttcttctgt    12660

ctgagatgaa ttttgtttgc ctcctgtgaa ggatgtatca ttcaaagtga atgttttgca    12720

actgccagta gtcccacatc gaccaaatat tcttattaca gtgtgtttat atagcacctg    12780

gagaaggaat gggttgtttc aaagattaaa taatttctac taagtgtaga tacacctact    12840

catctggcca ttgttaattt ctactaagtg tagatttttt tta                      12883


<210>  87
<211>  13155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3352 Full plasmid sequence

<400>  87
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt tgtaaccaac      480

atcccctgat gataatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggttggtgtg aaacagatga tttgctgctg taacaaagta     6240

aattatgtct cgacttttaa ggcccctttc attttattag attattttat tttaattaat     6300

gttcttgtcc cattttgcaa cagatggatg ctactacacc caagtattcc aaggccaggt     6360

atgatgaaat tgtgaaggaa gtctcttcct acttgaagaa agtaggatac aaccctgaca     6420

agattccttt tgttcctatc tctggttttg agggagacaa catgattgag aggtccacaa     6480

accttgactg gtacaagggt ccaactctgc ttgatgcact tgaccagatt agtgagccca     6540

agaggccctc tgacaagccc ctcaggcttc cccttcagga tgtgtacaag attggaggta     6600

ttggaactgt gccagtggga cgtgttgaga ccggtgtctt gaagcctgga atggtggtga     6660

cttttgcacc aactggactg acaactgaag tcaagtctgt ggagatgcac catgaatctc     6720

ttacagaggc acatcctggt gacaatgtgg gattcaatgt taagaatgtt gctgttaagg     6780

atttgaagcg tggttatgtt gcctcaaact caaaggatga ccctgcaaag gaggctgcta     6840

acttcacagc ccaagtcatc atcatgaacc accctggtca gattggaaat ggctatgccc     6900

ctgtcctcga ctgccacact tctcacattg ctgtcaagtt tgctgaactc atgaccaaga     6960

ttgacaggcg atccggcaaa gagcttgaga aggagcccaa gtttttgaag aacggtgatg     7020

ctggttttgt taagatgatt ccaaccaaac ccatggttgt tgaaactttc tccgagtatc     7080

ctccacttgg taggtttgct gttagggaca tgcgtcaaac tgttgctgtg ggagtcatca     7140

agaacgttga gaagaaggat cctaccggag ccaaggtcac caaggctgcc cagaagaaga     7200

agtcaaatgc tgctgatgaa gtggcaactc aattactgaa ttttgacctc ttgaagcttg     7260

ccggtgatgt tgagtctaac cctggaccaa tggcgcaagt tagcagaatc tgcaatggtg     7320

tgcagaaccc atctcttatc tccaatctct cgaaatccag tcaacgcaaa tctcccttat     7380

cggtttctct gaagacgcag cagcatccac gagcttatcc gatttcgtcg tcgtggggat     7440

tgaagaagag tgggatgacg ttaattggct ctgagcttcg tcctcttaag gtcatgtctt     7500

ctgtttccac ggcgtgcatg ggggaagcgg tgatcgccga agtatcgact caactatcag     7560

aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta catttgtacg     7620

gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg gttacggtga     7680

ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg gaaacttcgg     7740

cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt gtgcacgacg     7800

acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa tggcagcgca     7860

atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg gctatcttgc     7920

tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag gaactctttg     7980

atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg ctatggaact     8040

cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc cgcatttggt     8100

acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg gcaatggagc     8160

gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat cttggacaag     8220

aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac tacgtgaaag     8280

gcgagatcac caaggtagtc ggcaaatgaa tcgtgcgggc tggttcatca gggaatgttg     8340

gctacaatca atgttggttt cttttctgta ctcttgtgtc ttcttttcta ggtagcttgt     8400

ttttcggaca aagtttgaag tctccaccat catctcgcaa ctgttgttcc cagaactggg     8460

ttcttgatcg acggtggcaa aattgctttt atttatctgt gttttaatgt gttgtgtttg     8520

tcggaacccc tgattacatt tttgttaagc gcagcgagtt tcaggacttt gctgcgttgt     8580

gttgctttgg tttattaaat gtcaactttc tatttgtagt gttcaatttt tggcttggtt     8640

tgctttttct ttataatttg tgttcaaatt ttggcttggt ttgcttttac tataatttgt     8700

gttcaaattt tgggttggat tttttaacga tcggctgttt gctcttcttc ctctgttttg     8760

atgtgttcgt gactatgcaa gaatcttcaa ttttgctaaa ataaacttgc tttgacaaca     8820

tagaatcaaa tccgagtgct ttaatattcg gtggtttgtt tttatttttg gttttatgaa     8880

agttaaaatt ttaaaagtaa atcgataagg tataattgtg gtttttattt atcgagaatt     8940

ttttaagtga atcgatataa tttatttccc ctaaaataaa ataccaaaga atcgaattcg     9000

aactttgtct ttaataaaac tactaattta atcattattt gttctgtgta agcatgagaa     9060

ataaattcta cttatctttt agtttaaaac caaaacaggt taagaataat ttttctaagg     9120

ccgttatcaa ggtcaccaaa aatctattcg atctgaccat atattttcga tacttgtacg     9180

attcgcagat gttgattgga aattgcaatg aataaattac aaatgccaaa tccgattatg     9240

caatgaatga attacaagtg catttatccg ttttgaatct gttcatgtct accaatggga     9300

gagatttttt tcctgcatct gccatacata tgggaagacc gaaaatactt tcctaggctg     9360

gcagcacatc ccccgttcgc gagctggcgt aacagcgaag aggcccgggc gcgcctagct     9420

aactagctag ccacgtgact cgcagaacgt tgtgtggcga gacggaaaga aagtcacgcc     9480

tccaaagagt gcagcatctc ttctggctct cacggtcctc tgtggatcca tcgatatcga     9540

attcctgcag gctcgaggtc attcatatgc ttgagaagag agtcgggata gtccaaaata     9600

aaacaaaggt aagattacct ggtcaaaagt gaaaacatca gttaaaaggt ggtataaagt     9660

aaaatatcgg taataaaagg tggcccaaag tgaaatttac tcttttctac tattataaaa     9720

attgaggatg tttttgtcgg tactttgata cgtcattttt gtatgaattg gtttttaagt     9780

ttattcgctt ttggaaatgc atatctgtat ttgagtcggg ttttaagttc gtttgctttt     9840

gtaaatacag agggatttgt ataagaaata tctttagaaa aacccatatg ctaatttgac     9900

ataatttttg agaaaaatat atattcaggc gaattctcac aatgaacaat aataagatta     9960

aaatagcttt cccccgttgc agcgcatggg tattttttct agtaaaaata aaagataaac    10020

ttagactcaa aacatttaca aaaacaaccc ctaaagttcc taaagcccaa agtgctatcc    10080

acgatccata gcaagcccag cccaacccaa cccaacccaa cccaccccag tccagccaac    10140

tggacaatag tctccacacc cccccactat caccgtgagt tgtccgcacg caccgcacgt    10200

ctcgcagcca aaaaaaaaaa gaaagaaaaa aaagaaaaag aaaaaacagc aggtgggtcc    10260

gggtcgtggg ggccggaaac gcgaggagga tcgcgagcca gcgacgagga gcttaggcct    10320

catcgttgaa gatgcctctg ccgacagtgg tcccaaagat ggacccccac ccacgaggag    10380

catcgtggaa aaagaagacg ttccaaccac gtcttcaaag caagtggatt gatgtgatat    10440

ctccactgac gtaagggatg acgcacaatc ccactatcct tcgaggcctc atcgttgaag    10500

atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc atcgtggaaa    10560

aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc tccactgacg    10620

taagggatga cgcacaatcc cactatcctt cgaagctccc tccctccgct tccaaagaaa    10680

cgccccccat cgccactata tacatacccc cccctctcct cccatccccc caacccttct    10740

agaaccatct tccacacact caagccacac tattggagaa cacacaggga caacacacca    10800

taagatccaa gggaggcctc cgccgccgcc ggtaaccacc ccgcccctct cctctttctt    10860

tctccgtttt tttttccgtc tcggtctcga tctttggcct tggtagtttg ggtgggcgag    10920

aggcggcttc gtgcgcgccc agatcggtgc gcgggagggg cgggatctcg cggctggggc    10980

tctcgccggc gtggatccgg cccggatctc gcggggaatg gggctctcgg atgtagatct    11040

gcgatccgcc gttgttgggg gagatgatgg ggggtttaaa atttccgccg tgctaaacaa    11100

gatcaggaag aggggaaaag ggcactatgg tttatatttt tatatatttc tgctgcttcg    11160

tcaggcttag atgtgctaga tctttctttc ttctttttgt gggtagaatt tgaatccctc    11220

agcattgttc atcggtagtt tttcttttca tgatttgtga caaatgcagc ctcgtgcgga    11280

gcttttttgt aggtagaagg cggccgcatg gcccagtcta agcacgggtt gacgaaggag    11340

atgactatga agtatcgcat ggaaggctgc gttgacggcc acaaattcgt cattaccggc    11400

gagggcatcg gctacccctt taaggtaagt ttctgcttct acctttgata tatatataat    11460

aattatcatt aattagtagt aatataatat ttcaaatatt tttttcaaaa taaaagaatg    11520

tagtatatag caattgcttt tctgtagttt ataagtgtgt atattttaat ttataacttt    11580

tctaatatat gaccaaaatt tgttgatgtg cagggcaagc aagcgataaa cctgtgcgtg    11640

gtggagggtg gccctctgcc cttcgccgag gatatactct cagccgcctt catgtacggg    11700

aatcgggtgt tcacggagta cccgcaagac atcgtggact acttcaagaa ctcctgcccc    11760

gccggataca catgggaccg ttccttcctc ttcgaggacg gagccgtttg catctgcaac    11820

gcggacatca ccgtgtccgt cgaggagaac tgcatgtacc acgagtcaaa gttctatgga    11880

gtgaacttcc cggccgatgg tcccgtgatg aagaaaatga cggacaactg ggagccgtcg    11940

tgcgagaaaa tcattcccgt cccaaaacag ggaatcctca agggcgacgt gtcgatgtac    12000

ctacttctca aggacggtgg acggctacgg tgccagttcg acactgttta caaggcgaag    12060

tcggtgccga ggaagatgcc ggactggcac tttatccagc acaagctgac aagggaggac    12120

agaagcgacg ctaagaacca gaaatggcac ctcaccgagc acgccatcgc cagtggctct    12180

gcgctgcccg ggtgaccctg caatgtgacc ctagacttgt ccatcttctg gattggccaa    12240

cttaattaat gtatgaaata aaaggatgca cacatagtga catgctaatc actataatgt    12300

gggcatcaaa gttgtgtgtt atgtgtaatt actaattatc tgaataagag aaagagatca    12360

tccatatttc ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat    12420

gcattttatt aaccaattcc atatacatat aaatattaat catatataat taatatcaat    12480

tgggttagca aaacaaatct agtctaggtg tgttttgcta attattgggg gatagtgcaa    12540

aaagaaatct acgttctcaa taattcagat agaaaactta ataaagtgag ataatttaca    12600

tagattgctt ttatcctttg atatatgtga aaccatgcat gatataagga aaatagatag    12660

agaaataatt ttttacatcg ttgaatatgt aaacaattta attcaagaag ctaggaatat    12720

aaatattgag gagtttatga ttattattat tattttgatg ttcaatgaag ttttttttaa    12780

tttcatatga agtatacaaa aattcttcat agatttttgt ttctatgccg tagttatctt    12840

taatatattt gtggttgaag aaatttattg ctagaaacga atggattgtc aatttttttt    12900

taaagcaaat atatatgaaa ttatactgta tattatttta gtcatgatta aaatgtggcc    12960

ttaattgaat catctttctc attcattttt tcaaaagcat atcaggatga ttgatattta    13020

tctattttaa aaattaattt aagggttcaa attaaattta acttaaaagt gtcctaaccg    13080

tagttaaagg tttactttaa aaaaatacta tgaaaaatct aatcttctat gaatcgaggg    13140

cccttagcta gttag                                                     13155


<210>  88
<211>  13155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3358 Full plasmid sequence

<400>  88
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt tgtaaccaac      480

atcccctgat gataatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggaaagtatt ttcggtcttc ccatatgtat ggcagatgca     6240

ggaaaaaaat ctctcccatt ggtagacatg aacagattca aaacggataa atgcacttgt     6300

aattcattca ttgcataatc ggatttggca tttgtaattt attcattgca atttccaatc     6360

aacatctgcg aatcgtacaa gtatcgaaaa tatatggtca gatcgaatag atttttggtg     6420

accttgataa cggccttaga aaaattattc ttaacctgtt ttggttttaa actaaaagat     6480

aagtagaatt tatttctcat gcttacacag aacaaataat gattaaatta gtagttttat     6540

taaagacaaa gttcgaattc gattctttgg tattttattt taggggaaat aaattatatc     6600

gattcactta aaaaattctc gataaataaa aaccacaatt ataccttatc gatttacttt     6660

taaaatttta actttcataa aaccaaaaat aaaaacaaac caccgaatat taaagcactc     6720

ggatttgatt ctatgttgtc aaagcaagtt tattttagca aaattgaaga ttcttgcata     6780

gtcacgaaca catcaaaaca gaggaagaag agcaaacagc cgatcgttaa aaaatccaac     6840

ccaaaatttg aacacaaatt atagtaaaag caaaccaagc caaaatttga acacaaatta     6900

taaagaaaaa gcaaaccaag ccaaaaattg aacactacaa atagaaagtt gacatttaat     6960

aaaccaaagc aacacaacgc agcaaagtcc tgaaactcgc tgcgcttaac aaaaatgtaa     7020

tcaggggttc cgacaaacac aacacattaa aacacagata aataaaagca attttgccac     7080

cgtcgatcaa gaacccagtt ctgggaacaa cagttgcgag atgatggtgg agacttcaaa     7140

ctttgtccga aaaacaagct acctagaaaa gaagacacaa gagtacagaa aagaaaccaa     7200

cattgattgt agccaacatt ccctgatgaa ccagcccgca cgattcattt gccgactacc     7260

ttggtgatct cgcctttcac gtagtggaca aattcttcca actgatctgc gcgcgaggcc     7320

aagcgatctt cttcttgtcc aagataagcc tgtctagctt caagtatgac gggctgatac     7380

tgggccggca ggcgctccat tgcccagtcg gcagcgacat ccttcggcgc gattttgccg     7440

gttactgcgc tgtaccaaat gcgggacaac gtaagcacta catttcgctc atcgccagcc     7500

cagtcgggcg gcgagttcca tagcgttaag gtttcattta gcgcctcaaa tagatcctgt     7560

tcaggaaccg gatcaaagag ttcctccgcc gctggaccta ccaaggcaac gctatgttct     7620

cttgcttttg tcagcaagat agccagatca atgtcgatcg tggctggctc gaagatacct     7680

gcaagaatgt cattgcgctg ccattctcca aattgcagtt cgcgcttagc tggataacgc     7740

cacggaatga tgtcgtcgtg cacaacaatg gtgacttcta cagcgcggag aatctcgctc     7800

tctccagggg aagccgaagt ttccaaaagg tcgttgatca aagctcgccg cgttgtttca     7860

tcaagcctta cggtcaccgt aaccagcaaa tcaatatcac tgtgtggctt caggccgcca     7920

tccactgcgg agccgtacaa atgtacggcc agcaacgtcg gttcgagatg gcgctcgatg     7980

acgccaacta cctctgatag ttgagtcgat acttcggcga tcaccgcttc ccccatgcac     8040

gccgtggaaa cagaagacat gaccttaaga ggacgaagct cagagccaat taacgtcatc     8100

ccactcttct tcaatcccca cgacgacgaa atcggataag ctcgtggatg ctgctgcgtc     8160

ttcagagaaa ccgataaggg agatttgcgt tgactggatt tcgagagatt ggagataaga     8220

gatgggttct gcacaccatt gcagattctg ctaacttgcg ccattggtcc agggttagac     8280

tcaacatcac cggcaagctt caagaggtca aaattcagta attgagttgc cacttcatca     8340

gcagcatttg acttcttctt ctgggcagcc ttggtgacct tggctccggt aggatccttc     8400

ttctcaacgt tcttgatgac tcccacagca acagtttgac gcatgtccct aacagcaaac     8460

ctaccaagtg gaggatactc ggagaaagtt tcaacaacca tgggtttggt tggaatcatc     8520

ttaacaaaac cagcatcacc gttcttcaaa aacttgggct ccttctcaag ctctttgccg     8580

gatcgcctgt caatcttggt catgagttca gcaaacttga cagcaatgtg agaagtgtgg     8640

cagtcgagga caggggcata gccatttcca atctgaccag ggtggttcat gatgatgact     8700

tgggctgtga agttagcagc ctcctttgca gggtcatcct ttgagtttga ggcaacataa     8760

ccacgcttca aatccttaac agcaacattc ttaacattga atcccacatt gtcaccagga     8820

tgtgcctctg taagagattc atggtgcatc tccacagact tgacttcagt tgtcagtcca     8880

gttggtgcaa aagtcaccac cattccaggc ttcaagacac cggtctcaac acgtcccact     8940

ggcacagttc caatacctcc aatcttgtac acatcctgaa ggggaagcct gaggggcttg     9000

tcagagggcc tcttgggctc actaatctgg tcaagtgcat caagcagagt tggacccttg     9060

taccagtcaa ggtttgtgga cctctcaatc atgttgtctc cctcaaaacc agagatagga     9120

acaaaaggaa tcttgtcagg gttgtatcct actttcttca agtaggaaga gacttccttc     9180

acaatttcat catacctggc cttggaatac ttgggtgtag tagcatccat ctgttgcaaa     9240

atgggacaag aacattaatt aaaataaaat aatctaataa aatgaaaggg gccttaaaag     9300

tcgagacata atttactttg ttacagcagc aaatcatctg tttcacacca acctaggctg     9360

gcagcacatc ccccgttcgc gagctggcgt aacagcgaag aggcccgggc gcgcctagct     9420

aactagctag ccacgtgact cgcagaacgt tgtgtggcga gacggaaaga aagtcacgcc     9480

tccaaagagt gcagcatctc ttctggctct cacggtcctc tgtggatcca tcgatatcga     9540

attcctgcag gctcgaggtc attcatatgc ttgagaagag agtcgggata gtccaaaata     9600

aaacaaaggt aagattacct ggtcaaaagt gaaaacatca gttaaaaggt ggtataaagt     9660

aaaatatcgg taataaaagg tggcccaaag tgaaatttac tcttttctac tattataaaa     9720

attgaggatg tttttgtcgg tactttgata cgtcattttt gtatgaattg gtttttaagt     9780

ttattcgctt ttggaaatgc atatctgtat ttgagtcggg ttttaagttc gtttgctttt     9840

gtaaatacag agggatttgt ataagaaata tctttagaaa aacccatatg ctaatttgac     9900

ataatttttg agaaaaatat atattcaggc gaattctcac aatgaacaat aataagatta     9960

aaatagcttt cccccgttgc agcgcatggg tattttttct agtaaaaata aaagataaac    10020

ttagactcaa aacatttaca aaaacaaccc ctaaagttcc taaagcccaa agtgctatcc    10080

acgatccata gcaagcccag cccaacccaa cccaacccaa cccaccccag tccagccaac    10140

tggacaatag tctccacacc cccccactat caccgtgagt tgtccgcacg caccgcacgt    10200

ctcgcagcca aaaaaaaaaa gaaagaaaaa aaagaaaaag aaaaaacagc aggtgggtcc    10260

gggtcgtggg ggccggaaac gcgaggagga tcgcgagcca gcgacgagga gcttaggcct    10320

catcgttgaa gatgcctctg ccgacagtgg tcccaaagat ggacccccac ccacgaggag    10380

catcgtggaa aaagaagacg ttccaaccac gtcttcaaag caagtggatt gatgtgatat    10440

ctccactgac gtaagggatg acgcacaatc ccactatcct tcgaggcctc atcgttgaag    10500

atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc atcgtggaaa    10560

aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc tccactgacg    10620

taagggatga cgcacaatcc cactatcctt cgaagctccc tccctccgct tccaaagaaa    10680

cgccccccat cgccactata tacatacccc cccctctcct cccatccccc caacccttct    10740

agaaccatct tccacacact caagccacac tattggagaa cacacaggga caacacacca    10800

taagatccaa gggaggcctc cgccgccgcc ggtaaccacc ccgcccctct cctctttctt    10860

tctccgtttt tttttccgtc tcggtctcga tctttggcct tggtagtttg ggtgggcgag    10920

aggcggcttc gtgcgcgccc agatcggtgc gcgggagggg cgggatctcg cggctggggc    10980

tctcgccggc gtggatccgg cccggatctc gcggggaatg gggctctcgg atgtagatct    11040

gcgatccgcc gttgttgggg gagatgatgg ggggtttaaa atttccgccg tgctaaacaa    11100

gatcaggaag aggggaaaag ggcactatgg tttatatttt tatatatttc tgctgcttcg    11160

tcaggcttag atgtgctaga tctttctttc ttctttttgt gggtagaatt tgaatccctc    11220

agcattgttc atcggtagtt tttcttttca tgatttgtga caaatgcagc ctcgtgcgga    11280

gcttttttgt aggtagaagg cggccgcatg gcccagtcta agcacgggtt gacgaaggag    11340

atgactatga agtatcgcat ggaaggctgc gttgacggcc acaaattcgt cattaccggc    11400

gagggcatcg gctacccctt taaggtaagt ttctgcttct acctttgata tatatataat    11460

aattatcatt aattagtagt aatataatat ttcaaatatt tttttcaaaa taaaagaatg    11520

tagtatatag caattgcttt tctgtagttt ataagtgtgt atattttaat ttataacttt    11580

tctaatatat gaccaaaatt tgttgatgtg cagggcaagc aagcgataaa cctgtgcgtg    11640

gtggagggtg gccctctgcc cttcgccgag gatatactct cagccgcctt catgtacggg    11700

aatcgggtgt tcacggagta cccgcaagac atcgtggact acttcaagaa ctcctgcccc    11760

gccggataca catgggaccg ttccttcctc ttcgaggacg gagccgtttg catctgcaac    11820

gcggacatca ccgtgtccgt cgaggagaac tgcatgtacc acgagtcaaa gttctatgga    11880

gtgaacttcc cggccgatgg tcccgtgatg aagaaaatga cggacaactg ggagccgtcg    11940

tgcgagaaaa tcattcccgt cccaaaacag ggaatcctca agggcgacgt gtcgatgtac    12000

ctacttctca aggacggtgg acggctacgg tgccagttcg acactgttta caaggcgaag    12060

tcggtgccga ggaagatgcc ggactggcac tttatccagc acaagctgac aagggaggac    12120

agaagcgacg ctaagaacca gaaatggcac ctcaccgagc acgccatcgc cagtggctct    12180

gcgctgcccg ggtgaccctg caatgtgacc ctagacttgt ccatcttctg gattggccaa    12240

cttaattaat gtatgaaata aaaggatgca cacatagtga catgctaatc actataatgt    12300

gggcatcaaa gttgtgtgtt atgtgtaatt actaattatc tgaataagag aaagagatca    12360

tccatatttc ttatcctaaa tgaatgtcac gtgtctttat aattctttga tgaaccagat    12420

gcattttatt aaccaattcc atatacatat aaatattaat catatataat taatatcaat    12480

tgggttagca aaacaaatct agtctaggtg tgttttgcta attattgggg gatagtgcaa    12540

aaagaaatct acgttctcaa taattcagat agaaaactta ataaagtgag ataatttaca    12600

tagattgctt ttatcctttg atatatgtga aaccatgcat gatataagga aaatagatag    12660

agaaataatt ttttacatcg ttgaatatgt aaacaattta attcaagaag ctaggaatat    12720

aaatattgag gagtttatga ttattattat tattttgatg ttcaatgaag ttttttttaa    12780

tttcatatga agtatacaaa aattcttcat agatttttgt ttctatgccg tagttatctt    12840

taatatattt gtggttgaag aaatttattg ctagaaacga atggattgtc aatttttttt    12900

taaagcaaat atatatgaaa ttatactgta tattatttta gtcatgatta aaatgtggcc    12960

ttaattgaat catctttctc attcattttt tcaaaagcat atcaggatga ttgatattta    13020

tctattttaa aaattaattt aagggttcaa attaaattta acttaaaagt gtcctaaccg    13080

tagttaaagg tttactttaa aaaaatacta tgaaaaatct aatcttctat gaatcgaggg    13140

cccttagcta gttag                                                     13155


<210>  89
<211>  13151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3361 Full plasmid sequence

<400>  89
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt gtgtgatgtt      480

cgatgttgga tttaatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggttaggatt ttttttcacg aaattgcttc ttgaaattac     6240

gtgatggatt ttgattctga tttatcttgt gattgttgac tctacagatg cagatcttcg     6300

tcaagaccct caccggaaag accatcaccc ttgaggtgga aagctctgac accatcgaca     6360

acgtcaaggc caagatccag gacaaggaag gaattccccc ggatcagcaa cgtctcatct     6420

tcgccggaaa gcagctcgag gacggccgta ccctcgccga ctacaacatc cagaaggagt     6480

caacccttca ccttgtcctt cgtctccgtg gtggcatgca gatcttcgtc aagactctca     6540

ctggcaaaac cataacccta gaggtcgaaa gctctgacac cattgacaac gtcaaggcca     6600

agatccagga caaggaggga atccccccag accagcaacg tctcatcttc gccggaaagc     6660

aacttgagga cgggcgcacc ctcgccgact acaacatcca gaaggaatca acccttcacc     6720

tcgtcctccg tctccgtggt ggcatgcaga tcttcgttaa gaccctcacc ggcaagacta     6780

taaccctaga agtcgagagc tccgacacca tcgacaacgt caaggctaag atccaggaca     6840

aggagggtat ccccccagac cagcagaggc tgatcttcgc cggcaagcag ctcgaggacg     6900

gacgtaccct tgctgactac aacatccaga aggagtcaac tctccacttg gtgttgcgtc     6960

ttcgtggtgg tatgcagatc ttcgtcaaga cccttacggg taagactatt accctcgagg     7020

tggagagctc cgacaccatt gacaatgtga aggcgaagat ccaggacaag gaaggaatcc     7080

caccggacca gcagaggctt atttttgctg gcaaacagct agaggatgga aggaccctcg     7140

ctgactacaa catccagaag gagtcaactc tgcacttggt gttgcgtctt cgtggggggt     7200

tttcaaatgc tgctgatgaa gtggcaactc aattactgaa ttttgacctc ttgaagcttg     7260

ccggtgatgt tgagtctaac cctggaccaa tggcgcaagt tagcagaatc tgcaatggtg     7320

tgcagaaccc atctcttatc tccaatctct cgaaatccag tcaacgcaaa tctcccttat     7380

cggtttctct gaagacgcag cagcatccac gagcttatcc gatttcgtcg tcgtggggat     7440

tgaagaagag tgggatgacg ttaattggct ctgagcttcg tcctcttaag gtcatgtctt     7500

ctgtttccac ggcgtgcatg ggggaagcgg tgatcgccga agtatcgact caactatcag     7560

aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta catttgtacg     7620

gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg gttacggtga     7680

ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg gaaacttcgg     7740

cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt gtgcacgacg     7800

acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa tggcagcgca     7860

atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg gctatcttgc     7920

tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag gaactctttg     7980

atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg ctatggaact     8040

cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc cgcatttggt     8100

acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg gcaatggagc     8160

gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat cttggacaag     8220

aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac tacgtgaaag     8280

gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg atgtctgatg     8340

ttggattttc ccagacattt taagaagaaa tgtgatgtgt aatgggtctg taatgacctt     8400

tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact actgtttgtt     8460

atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg tgtttgaatt     8520

ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc atgcttatca     8580

cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga attattagat     8640

tttggtatta taggttaaag atatttatta ggtagggaga actcttggat tagattctaa     8700

agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat gatccctagt     8760

ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg tgaagcatat     8820

ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta attggcttgc     8880

ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc aattttagtt     8940

atgcaatctt tctgcttcag gtagtccttg tcttacagaa agcacattga gatgatcccc     9000

acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt aaaagatgta     9060

atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc aaaaaatacc     9120

aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat ttgattacca     9180

aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac tggaccccaa     9240

attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt taaaatccca     9300

tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacct aggctggcag     9360

cacatccccc gttcgcgagc tggcgtaaca gcgaagaggc ccgggcgcgc ctagctaact     9420

agctagccac gtgactcgca gaacgttgtg tggcgagacg gaaagaaagt cacgcctcca     9480

aagagtgcag catctcttct ggctctcacg gtcctctgtg gatccatcga tatcgaattc     9540

ctgcaggctc gaggtcattc atatgcttga gaagagagtc gggatagtcc aaaataaaac     9600

aaaggtaaga ttacctggtc aaaagtgaaa acatcagtta aaaggtggta taaagtaaaa     9660

tatcggtaat aaaaggtggc ccaaagtgaa atttactctt ttctactatt ataaaaattg     9720

aggatgtttt tgtcggtact ttgatacgtc atttttgtat gaattggttt ttaagtttat     9780

tcgcttttgg aaatgcatat ctgtatttga gtcgggtttt aagttcgttt gcttttgtaa     9840

atacagaggg atttgtataa gaaatatctt tagaaaaacc catatgctaa tttgacataa     9900

tttttgagaa aaatatatat tcaggcgaat tctcacaatg aacaataata agattaaaat     9960

agctttcccc cgttgcagcg catgggtatt ttttctagta aaaataaaag ataaacttag    10020

actcaaaaca tttacaaaaa caacccctaa agttcctaaa gcccaaagtg ctatccacga    10080

tccatagcaa gcccagccca acccaaccca acccaaccca ccccagtcca gccaactgga    10140

caatagtctc cacacccccc cactatcacc gtgagttgtc cgcacgcacc gcacgtctcg    10200

cagccaaaaa aaaaaagaaa gaaaaaaaag aaaaagaaaa aacagcaggt gggtccgggt    10260

cgtgggggcc ggaaacgcga ggaggatcgc gagccagcga cgaggagctt aggcctcatc    10320

gttgaagatg cctctgccga cagtggtccc aaagatggac ccccacccac gaggagcatc    10380

gtggaaaaag aagacgttcc aaccacgtct tcaaagcaag tggattgatg tgatatctcc    10440

actgacgtaa gggatgacgc acaatcccac tatccttcga ggcctcatcg ttgaagatgc    10500

ctctgccgac agtggtccca aagatggacc cccacccacg aggagcatcg tggaaaaaga    10560

agacgttcca accacgtctt caaagcaagt ggattgatgt gatatctcca ctgacgtaag    10620

ggatgacgca caatcccact atccttcgaa gctccctccc tccgcttcca aagaaacgcc    10680

ccccatcgcc actatataca tacccccccc tctcctccca tccccccaac ccttctagaa    10740

ccatcttcca cacactcaag ccacactatt ggagaacaca cagggacaac acaccataag    10800

atccaaggga ggcctccgcc gccgccggta accaccccgc ccctctcctc tttctttctc    10860

cgtttttttt tccgtctcgg tctcgatctt tggccttggt agtttgggtg ggcgagaggc    10920

ggcttcgtgc gcgcccagat cggtgcgcgg gaggggcggg atctcgcggc tggggctctc    10980

gccggcgtgg atccggcccg gatctcgcgg ggaatggggc tctcggatgt agatctgcga    11040

tccgccgttg ttgggggaga tgatgggggg tttaaaattt ccgccgtgct aaacaagatc    11100

aggaagaggg gaaaagggca ctatggttta tatttttata tatttctgct gcttcgtcag    11160

gcttagatgt gctagatctt tctttcttct ttttgtgggt agaatttgaa tccctcagca    11220

ttgttcatcg gtagtttttc ttttcatgat ttgtgacaaa tgcagcctcg tgcggagctt    11280

ttttgtaggt agaaggcggc cgcatggccc agtctaagca cgggttgacg aaggagatga    11340

ctatgaagta tcgcatggaa ggctgcgttg acggccacaa attcgtcatt accggcgagg    11400

gcatcggcta cccctttaag gtaagtttct gcttctacct ttgatatata tataataatt    11460

atcattaatt agtagtaata taatatttca aatatttttt tcaaaataaa agaatgtagt    11520

atatagcaat tgcttttctg tagtttataa gtgtgtatat tttaatttat aacttttcta    11580

atatatgacc aaaatttgtt gatgtgcagg gcaagcaagc gataaacctg tgcgtggtgg    11640

agggtggccc tctgcccttc gccgaggata tactctcagc cgccttcatg tacgggaatc    11700

gggtgttcac ggagtacccg caagacatcg tggactactt caagaactcc tgccccgccg    11760

gatacacatg ggaccgttcc ttcctcttcg aggacggagc cgtttgcatc tgcaacgcgg    11820

acatcaccgt gtccgtcgag gagaactgca tgtaccacga gtcaaagttc tatggagtga    11880

acttcccggc cgatggtccc gtgatgaaga aaatgacgga caactgggag ccgtcgtgcg    11940

agaaaatcat tcccgtccca aaacagggaa tcctcaaggg cgacgtgtcg atgtacctac    12000

ttctcaagga cggtggacgg ctacggtgcc agttcgacac tgtttacaag gcgaagtcgg    12060

tgccgaggaa gatgccggac tggcacttta tccagcacaa gctgacaagg gaggacagaa    12120

gcgacgctaa gaaccagaaa tggcacctca ccgagcacgc catcgccagt ggctctgcgc    12180

tgcccgggtg accctgcaat gtgaccctag acttgtccat cttctggatt ggccaactta    12240

attaatgtat gaaataaaag gatgcacaca tagtgacatg ctaatcacta taatgtgggc    12300

atcaaagttg tgtgttatgt gtaattacta attatctgaa taagagaaag agatcatcca    12360

tatttcttat cctaaatgaa tgtcacgtgt ctttataatt ctttgatgaa ccagatgcat    12420

tttattaacc aattccatat acatataaat attaatcata tataattaat atcaattggg    12480

ttagcaaaac aaatctagtc taggtgtgtt ttgctaatta ttgggggata gtgcaaaaag    12540

aaatctacgt tctcaataat tcagatagaa aacttaataa agtgagataa tttacataga    12600

ttgcttttat cctttgatat atgtgaaacc atgcatgata taaggaaaat agatagagaa    12660

ataatttttt acatcgttga atatgtaaac aatttaattc aagaagctag gaatataaat    12720

attgaggagt ttatgattat tattattatt ttgatgttca atgaagtttt ttttaatttc    12780

atatgaagta tacaaaaatt cttcatagat ttttgtttct atgccgtagt tatctttaat    12840

atatttgtgg ttgaagaaat ttattgctag aaacgaatgg attgtcaatt tttttttaaa    12900

gcaaatatat atgaaattat actgtatatt attttagtca tgattaaaat gtggccttaa    12960

ttgaatcatc tttctcattc attttttcaa aagcatatca ggatgattga tatttatcta    13020

ttttaaaaat taatttaagg gttcaaatta aatttaactt aaaagtgtcc taaccgtagt    13080

taaaggttta ctttaaaaaa atactatgaa aaatctaatc ttctatgaat cgagggccct    13140

tagctagtta g                                                         13151


<210>  90
<211>  13151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3362 Full plasmid sequence

<400>  90
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt gtgtgatgtt      480

cgatgttgga tttaatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggtaatgaca tttgtttcat gtataaacct gcgttgttat     6240

ttgtaaaaat gggattttaa cccgatcgct tttgttttta tctgttaaac ggatccgatt     6300

ctgattaatt tggggtccag tattggagca gaaaaatacc actgaatagt gtttttattt     6360

tttggtattt ggtaatcaaa tttatattgg agcagaaaaa tatcactgaa taacttgttt     6420

tttctttttg gtattttttg gggtccagta tacaaaaact tgcacaaaaa ttagggatta     6480

gtatggcatt acatctttta atgattttca agttattatt gattaggaat tttttatgtg     6540

gatctgtgtg gggatcatct caatgtgctt tctgtaagac aaggactacc tgaagcagaa     6600

agattgcata actaaaattg attaggaatt tttatgtgga cctgtgtgga tcatctaaat     6660

gtgcattccg caagccaatt aatgttccaa ctgaagcaga ttgcttacat aatttatata     6720

cgataccaaa tatgcttcac gagcataatt tttaagttgc tacctcttgg taaggggcag     6780

ctaattgaaa ctagggatca tgatctccgt ttgttcaaaa atcctttggt gtgttttcaa     6840

aatatcactt tagaatctaa tccaagagtt ctccctacct aataaatatc tttaacctat     6900

aataccaaaa tctaataatt cgtgggatga tcaccatcct tcacacaact catccctgct     6960

tttcctccgt gataagcatg aagaataaaa aacccactaa tatacgccaa ttcactggat     7020

tgagaacaaa attcaaacac aatatgccag catacagttg ataattatat atcagctcca     7080

caaattgata acaaacagta gtaacattaa tgggacaata gagttcaaca caaaccaaac     7140

ttattttcaa aggtcattac agacccatta cacatcacat ttcttcttaa aatgtctggg     7200

aaaatccaac atcagacatc acacagacat cagctccagc ttatttgccg actaccttgg     7260

tgatctcgcc tttcacgtag tggacaaatt cttccaactg atctgcgcgc gaggccaagc     7320

gatcttcttc ttgtccaaga taagcctgtc tagcttcaag tatgacgggc tgatactggg     7380

ccggcaggcg ctccattgcc cagtcggcag cgacatcctt cggcgcgatt ttgccggtta     7440

ctgcgctgta ccaaatgcgg gacaacgtaa gcactacatt tcgctcatcg ccagcccagt     7500

cgggcggcga gttccatagc gttaaggttt catttagcgc ctcaaataga tcctgttcag     7560

gaaccggatc aaagagttcc tccgccgctg gacctaccaa ggcaacgcta tgttctcttg     7620

cttttgtcag caagatagcc agatcaatgt cgatcgtggc tggctcgaag atacctgcaa     7680

gaatgtcatt gcgctgccat tctccaaatt gcagttcgcg cttagctgga taacgccacg     7740

gaatgatgtc gtcgtgcaca acaatggtga cttctacagc gcggagaatc tcgctctctc     7800

caggggaagc cgaagtttcc aaaaggtcgt tgatcaaagc tcgccgcgtt gtttcatcaa     7860

gccttacggt caccgtaacc agcaaatcaa tatcactgtg tggcttcagg ccgccatcca     7920

ctgcggagcc gtacaaatgt acggccagca acgtcggttc gagatggcgc tcgatgacgc     7980

caactacctc tgatagttga gtcgatactt cggcgatcac cgcttccccc atgcacgccg     8040

tggaaacaga agacatgacc ttaagaggac gaagctcaga gccaattaac gtcatcccac     8100

tcttcttcaa tccccacgac gacgaaatcg gataagctcg tggatgctgc tgcgtcttca     8160

gagaaaccga taagggagat ttgcgttgac tggatttcga gagattggag ataagagatg     8220

ggttctgcac accattgcag attctgctaa cttgcgccat tggtccaggg ttagactcaa     8280

catcaccggc aagcttcaag aggtcaaaat tcagtaattg agttgccact tcatcagcag     8340

catttgaaaa ccccccacga agacgcaaca ccaagtgcag agttgactcc ttctggatgt     8400

tgtagtcagc gagggtcctt ccatcctcta gctgtttgcc agcaaaaata agcctctgct     8460

ggtccggtgg gattccttcc ttgtcctgga tcttcgcctt cacattgtca atggtgtcgg     8520

agctctccac ctcgagggta atagtcttac ccgtaagggt cttgacgaag atctgcatac     8580

caccacgaag acgcaacacc aagtggagag ttgactcctt ctggatgttg tagtcagcaa     8640

gggtacgtcc gtcctcgagc tgcttgccgg cgaagatcag cctctgctgg tctgggggga     8700

taccctcctt gtcctggatc ttagccttga cgttgtcgat ggtgtcggag ctctcgactt     8760

ctagggttat agtcttgccg gtgagggtct taacgaagat ctgcatgcca ccacggagac     8820

ggaggacgag gtgaagggtt gattccttct ggatgttgta gtcggcgagg gtgcgcccgt     8880

cctcaagttg ctttccggcg aagatgagac gttgctggtc tggggggatt ccctccttgt     8940

cctggatctt ggccttgacg ttgtcaatgg tgtcagagct ttcgacctct agggttatgg     9000

ttttgccagt gagagtcttg acgaagatct gcatgccacc acggagacga aggacaaggt     9060

gaagggttga ctccttctgg atgttgtagt cggcgagggt acggccgtcc tcgagctgct     9120

ttccggcgaa gatgagacgt tgctgatccg ggggaattcc ttccttgtcc tggatcttgg     9180

ccttgacgtt gtcgatggtg tcagagcttt ccacctcaag ggtgatggtc tttccggtga     9240

gggtcttgac gaagatctgc atctgtagag tcaacaatca caagataaat cagaatcaaa     9300

atccatcacg taatttcaag aagcaatttc gtgaaaaaaa atcctaacct aggctggcag     9360

cacatccccc gttcgcgagc tggcgtaaca gcgaagaggc ccgggcgcgc ctagctaact     9420

agctagccac gtgactcgca gaacgttgtg tggcgagacg gaaagaaagt cacgcctcca     9480

aagagtgcag catctcttct ggctctcacg gtcctctgtg gatccatcga tatcgaattc     9540

ctgcaggctc gaggtcattc atatgcttga gaagagagtc gggatagtcc aaaataaaac     9600

aaaggtaaga ttacctggtc aaaagtgaaa acatcagtta aaaggtggta taaagtaaaa     9660

tatcggtaat aaaaggtggc ccaaagtgaa atttactctt ttctactatt ataaaaattg     9720

aggatgtttt tgtcggtact ttgatacgtc atttttgtat gaattggttt ttaagtttat     9780

tcgcttttgg aaatgcatat ctgtatttga gtcgggtttt aagttcgttt gcttttgtaa     9840

atacagaggg atttgtataa gaaatatctt tagaaaaacc catatgctaa tttgacataa     9900

tttttgagaa aaatatatat tcaggcgaat tctcacaatg aacaataata agattaaaat     9960

agctttcccc cgttgcagcg catgggtatt ttttctagta aaaataaaag ataaacttag    10020

actcaaaaca tttacaaaaa caacccctaa agttcctaaa gcccaaagtg ctatccacga    10080

tccatagcaa gcccagccca acccaaccca acccaaccca ccccagtcca gccaactgga    10140

caatagtctc cacacccccc cactatcacc gtgagttgtc cgcacgcacc gcacgtctcg    10200

cagccaaaaa aaaaaagaaa gaaaaaaaag aaaaagaaaa aacagcaggt gggtccgggt    10260

cgtgggggcc ggaaacgcga ggaggatcgc gagccagcga cgaggagctt aggcctcatc    10320

gttgaagatg cctctgccga cagtggtccc aaagatggac ccccacccac gaggagcatc    10380

gtggaaaaag aagacgttcc aaccacgtct tcaaagcaag tggattgatg tgatatctcc    10440

actgacgtaa gggatgacgc acaatcccac tatccttcga ggcctcatcg ttgaagatgc    10500

ctctgccgac agtggtccca aagatggacc cccacccacg aggagcatcg tggaaaaaga    10560

agacgttcca accacgtctt caaagcaagt ggattgatgt gatatctcca ctgacgtaag    10620

ggatgacgca caatcccact atccttcgaa gctccctccc tccgcttcca aagaaacgcc    10680

ccccatcgcc actatataca tacccccccc tctcctccca tccccccaac ccttctagaa    10740

ccatcttcca cacactcaag ccacactatt ggagaacaca cagggacaac acaccataag    10800

atccaaggga ggcctccgcc gccgccggta accaccccgc ccctctcctc tttctttctc    10860

cgtttttttt tccgtctcgg tctcgatctt tggccttggt agtttgggtg ggcgagaggc    10920

ggcttcgtgc gcgcccagat cggtgcgcgg gaggggcggg atctcgcggc tggggctctc    10980

gccggcgtgg atccggcccg gatctcgcgg ggaatggggc tctcggatgt agatctgcga    11040

tccgccgttg ttgggggaga tgatgggggg tttaaaattt ccgccgtgct aaacaagatc    11100

aggaagaggg gaaaagggca ctatggttta tatttttata tatttctgct gcttcgtcag    11160

gcttagatgt gctagatctt tctttcttct ttttgtgggt agaatttgaa tccctcagca    11220

ttgttcatcg gtagtttttc ttttcatgat ttgtgacaaa tgcagcctcg tgcggagctt    11280

ttttgtaggt agaaggcggc cgcatggccc agtctaagca cgggttgacg aaggagatga    11340

ctatgaagta tcgcatggaa ggctgcgttg acggccacaa attcgtcatt accggcgagg    11400

gcatcggcta cccctttaag gtaagtttct gcttctacct ttgatatata tataataatt    11460

atcattaatt agtagtaata taatatttca aatatttttt tcaaaataaa agaatgtagt    11520

atatagcaat tgcttttctg tagtttataa gtgtgtatat tttaatttat aacttttcta    11580

atatatgacc aaaatttgtt gatgtgcagg gcaagcaagc gataaacctg tgcgtggtgg    11640

agggtggccc tctgcccttc gccgaggata tactctcagc cgccttcatg tacgggaatc    11700

gggtgttcac ggagtacccg caagacatcg tggactactt caagaactcc tgccccgccg    11760

gatacacatg ggaccgttcc ttcctcttcg aggacggagc cgtttgcatc tgcaacgcgg    11820

acatcaccgt gtccgtcgag gagaactgca tgtaccacga gtcaaagttc tatggagtga    11880

acttcccggc cgatggtccc gtgatgaaga aaatgacgga caactgggag ccgtcgtgcg    11940

agaaaatcat tcccgtccca aaacagggaa tcctcaaggg cgacgtgtcg atgtacctac    12000

ttctcaagga cggtggacgg ctacggtgcc agttcgacac tgtttacaag gcgaagtcgg    12060

tgccgaggaa gatgccggac tggcacttta tccagcacaa gctgacaagg gaggacagaa    12120

gcgacgctaa gaaccagaaa tggcacctca ccgagcacgc catcgccagt ggctctgcgc    12180

tgcccgggtg accctgcaat gtgaccctag acttgtccat cttctggatt ggccaactta    12240

attaatgtat gaaataaaag gatgcacaca tagtgacatg ctaatcacta taatgtgggc    12300

atcaaagttg tgtgttatgt gtaattacta attatctgaa taagagaaag agatcatcca    12360

tatttcttat cctaaatgaa tgtcacgtgt ctttataatt ctttgatgaa ccagatgcat    12420

tttattaacc aattccatat acatataaat attaatcata tataattaat atcaattggg    12480

ttagcaaaac aaatctagtc taggtgtgtt ttgctaatta ttgggggata gtgcaaaaag    12540

aaatctacgt tctcaataat tcagatagaa aacttaataa agtgagataa tttacataga    12600

ttgcttttat cctttgatat atgtgaaacc atgcatgata taaggaaaat agatagagaa    12660

ataatttttt acatcgttga atatgtaaac aatttaattc aagaagctag gaatataaat    12720

attgaggagt ttatgattat tattattatt ttgatgttca atgaagtttt ttttaatttc    12780

atatgaagta tacaaaaatt cttcatagat ttttgtttct atgccgtagt tatctttaat    12840

atatttgtgg ttgaagaaat ttattgctag aaacgaatgg attgtcaatt tttttttaaa    12900

gcaaatatat atgaaattat actgtatatt attttagtca tgattaaaat gtggccttaa    12960

ttgaatcatc tttctcattc attttttcaa aagcatatca ggatgattga tatttatcta    13020

ttttaaaaat taatttaagg gttcaaatta aatttaactt aaaagtgtcc taaccgtagt    13080

taaaggttta ctttaaaaaa atactatgaa aaatctaatc ttctatgaat cgagggccct    13140

tagctagtta g                                                         13151


<210>  91
<211>  19084
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3587 Full plasmid sequence

<400>  91
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt tgtaaccaac      480

atcccctgat gataatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggttggtgtg aaacagatga tttgctgctg taacaaagta     6240

aattatgtct cgacttttaa ggcccctttc attttattag attattttat tttaattaat     6300

gttcttgtcc cattttgcaa cagatggatg ctactacacc caagtattcc aaggccaggt     6360

atgatgaaat tgtgaaggaa gtctcttcct acttgaagaa agtaggatac aaccctgaca     6420

agattccttt tgttcctatc tctggttttg agggagacaa catgattgag aggtccacaa     6480

accttgactg gtacaagggt ccaactctgc ttgatgcact tgaccagatt agtgagccca     6540

agaggccctc tgacaagccc ctcaggcttc cccttcagga tgtgtacaag attggaggta     6600

ttggaactgt gccagtggga cgtgttgaga ccggtgtctt gaagcctgga atggtggtga     6660

cttttgcacc aactggactg acaactgaag tcaagtctgt ggagatgcac catgaatctc     6720

ttacagaggc acatcctggt gacaatgtgg gattcaatgt taagaatgtt gctgttaagg     6780

atttgaagcg tggttatgtt gcctcaaact caaaggatga ccctgcaaag gaggctgcta     6840

acttcacagc ccaagtcatc atcatgaacc accctggtca gattggaaat ggctatgccc     6900

ctgtcctcga ctgccacact tctcacattg ctgtcaagtt tgctgaactc atgaccaaga     6960

ttgacaggcg atccggcaaa gagcttgaga aggagcccaa gtttttgaag aacggtgatg     7020

ctggttttgt taagatgatt ccaaccaaac ccatggttgt tgaaactttc tccgagtatc     7080

ctccacttgg taggtttgct gttagggaca tgcgtcaaac tgttgctgtg ggagtcatca     7140

agaacgttga gaagaaggat cctaccggag ccaaggtcac caaggctgcc cagaagaaga     7200

agtcaaatgc tgctgatgaa gtggcaactc aattactgaa ttttgacctc ttgaagcttg     7260

ccggtgatgt tgagtctaac cctggaccaa tggcgcaagt tagcagaatc tgcaatggtg     7320

tgcagaaccc atctcttatc tccaatctct cgaaatccag tcaacgcaaa tctcccttat     7380

cggtttctct gaagacgcag cagcatccac gagcttatcc gatttcgtcg tcgtggggat     7440

tgaagaagag tgggatgacg ttaattggct ctgagcttcg tcctcttaag gtcatgtctt     7500

ctgtttccac ggcgtgcatg ggggaagcgg tgatcgccga agtatcgact caactatcag     7560

aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta catttgtacg     7620

gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg gttacggtga     7680

ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg gaaacttcgg     7740

cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt gtgcacgacg     7800

acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa tggcagcgca     7860

atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg gctatcttgc     7920

tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag gaactctttg     7980

atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg ctatggaact     8040

cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc cgcatttggt     8100

acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg gcaatggagc     8160

gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat cttggacaag     8220

aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac tacgtgaaag     8280

gcgagatcac caaggtagtc ggcaaatgaa tcgtgcgggc tggttcatca gggaatgttg     8340

gctacaatca atgttggttt cttttctgta ctcttgtgtc ttcttttcta ggtagcttgt     8400

ttttcggaca aagtttgaag tctccaccat catctcgcaa ctgttgttcc cagaactggg     8460

ttcttgatcg acggtggcaa aattgctttt atttatctgt gttttaatgt gttgtgtttg     8520

tcggaacccc tgattacatt tttgttaagc gcagcgagtt tcaggacttt gctgcgttgt     8580

gttgctttgg tttattaaat gtcaactttc tatttgtagt gttcaatttt tggcttggtt     8640

tgctttttct ttataatttg tgttcaaatt ttggcttggt ttgcttttac tataatttgt     8700

gttcaaattt tgggttggat tttttaacga tcggctgttt gctcttcttc ctctgttttg     8760

atgtgttcgt gactatgcaa gaatcttcaa ttttgctaaa ataaacttgc tttgacaaca     8820

tagaatcaaa tccgagtgct ttaatattcg gtggtttgtt tttatttttg gttttatgaa     8880

agttaaaatt ttaaaagtaa atcgataagg tataattgtg gtttttattt atcgagaatt     8940

ttttaagtga atcgatataa tttatttccc ctaaaataaa ataccaaaga atcgaattcg     9000

aactttgtct ttaataaaac tactaattta atcattattt gttctgtgta agcatgagaa     9060

ataaattcta cttatctttt agtttaaaac caaaacaggt taagaataat ttttctaagg     9120

ccgttatcaa ggtcaccaaa aatctattcg atctgaccat atattttcga tacttgtacg     9180

attcgcagat gttgattgga aattgcaatg aataaattac aaatgccaaa tccgattatg     9240

caatgaatga attacaagtg catttatccg ttttgaatct gttcatgtct accaatggga     9300

gagatttttt tcctgcatct gccatacata tgggaagacc gaaaatactt tcctaggctg     9360

gcagcacatc ccccgttcgc gagctggcgt aacagcgaag aggcccgggc gcgccactgt     9420

taataatttt taaacgtcag cgcactaaaa aaacgaaaag acggacacgt gaaaataaaa     9480

aacacacact agtttatgac gcaatactat tttacttatg atttgggtac attagacaaa     9540

accgtgaaag agatgtatca gctatgaaac ctgtatactt caatacagag acttactcat     9600

atcggatacg tacgcacgaa gtatcatatt aattatttta atttttaata aatattttat     9660

cggatactta tgtgatactc tacatataca caaggatatt tctaagatac tttatagata     9720

cgtatcctag aaaaacatga agagtaaaaa agtgagacaa tgttgtaaaa attcattata     9780

aatgtatatg attcaatttt agatatgcat cagtataatt gattctcgat gaaacactta     9840

aaattatatt tcttgtggaa gaacgtagcg agagaggtga ttcagttaga caacattaaa     9900

taaaattaat gttaagttct tttaatgatg tttctctcaa tatcacatca tatgaaaatg     9960

taatatgatt tataagaaaa tttttaaaaa atttatttta ataatcacat gtactatttt    10020

ttaaaaattg tatcttttat aataatacaa taataaagag taatcagtgt taatttttct    10080

tcaaatataa gttttattat aaatcattgt taacgtatca taagtcatta ccgtatcgta    10140

tcttaatttt tttttaaaaa ccgctaattc acgtacccgt attgtattgt acccgcacct    10200

gtatcacaat cgatcttagt tagaagaatt gtctcgaggc ggtgcaagac agcatataat    10260

agacgtggac tctcttatac caaacgttgt cgtatcacaa agggttaggt aacaagtcac    10320

agtttgtcca cgtgtcacgt tttaattgga agaggtgccg ttggcgtaat ataacagcca    10380

atcgattttt gctataaaag caaatcaggt aaactaaact tcttcattct tttcttcccc    10440

atcgctacaa aaccggttcc tttggaaaag agattcattc aaacctagca cccaattccg    10500

tttcaaggta taatctactt tctattcttc gattatttta ttattattag ctactatcgt    10560

ttaatcgatc ttttcttttg atccgtcaaa tttaaattca attagggttt tgttcttttc    10620

tttcatctga ttgaaatcct tctgaattga accgtttact tgattttact gtttattgta    10680

tgatttaatc ctttgttttt caaagacagt ctttagattg tgattagggg ttcatataaa    10740

tttttagatt tggatttttg tattgtatga ttcaaaaaat acgtccttta attagattag    10800

tacatggata ttttttaccc gatttattga ttgtcaggga gaatttgatg agcaagtttt    10860

tttgatgtct gttgtaaatt gaattgatta taattgctga tctgctgctt ccagttttca    10920

taacccatat tcttttaacc ttgttgtaca cacaatgaaa aattggtgat tgattcattt    10980

gtttttcttt gttttggatt atacagggta tggcgccgcc gcctgccctc cctccaaaga    11040

ggcgaagaag tggtggatct tccggggggt ccccccctcc tgctttacct ccaaaaagac    11100

gtcgttctgg tggttcaagt ggaggttctc cacctcctgc acttcctccc aagagaagaa    11160

ggagcggcgg cagctcagga ggatcaccac caccagcttt gccacccaaa aggcgccggg    11220

gctcctccga gacaccaggc acctccgaga gcgcgacgcc cgagggcggc tccggcggct    11280

ccggcagctc caagctggag aagtttacaa actgttacag cctctccaaa accctcaggt    11340

ttaaagcgat cccggtgggc aagacccagg agaacatcga caacaagagg ctcctggtgg    11400

aagacgagaa gcgcgccgaa gactacaagg gcgtgaagaa gctgctcgat aggtactacc    11460

tcagctttat taacgacgtg ctgcacagca tcaaactcaa gaatctcaac aactacatct    11520

ccctcttccg caaaaagacc cgcaccgaga aggagaacaa ggagctggag aacctggaga    11580

tcaacctccg caaggaaatc gccaaagcgt tcaagggcaa tgaagggtac aagagcctct    11640

tcaagaaaga catcatcgaa actatcctcc cagagtttct cgatgacaag gacgagatcg    11700

cgctggtgaa ctcctttaac gggttcacaa ccgcgtttac cggcttcttt gataacaggg    11760

aaaatatgtt ctccgaggag gccaagtcca ccagcatcgc cttcaggtgt atcaacgaga    11820

acctcacccg ctacatttcc aatatggaca ttttcgagaa ggtggatgcg atcttcgata    11880

agcacgaggt gcaggagatc aaagagaaga ttctcaattc cgattatgac gtcgaggatt    11940

tcttcgaagg ggagttcttt aattttgtgc tcacacaaga gggcattgac gtgtacaacg    12000

cgattatcgg gggcttcgtc acagagtccg gggagaagat taaggggctg aatgagtaca    12060

tcaatctgta caatcagaag accaagcaga aactgccgaa attcaagccg ctctacaagc    12120

aagtcctgtc cgatagggaa agcctctcct tctacggcga gggctatacc agcgacgagg    12180

aggtgctgga agtcttccgc aacacactga ataagaatag cgagattttc tcctccatca    12240

agaagctcga gaagctcttt aagaactttg acgagtacag ctccgccggg attttcgtga    12300

agaacgggcc ggcgatcagc accatctcca aggacatctt tggcgagtgg aacgtcatca    12360

gggacaagtg gaacgccgag tacgacgaca tccacctgaa gaagaaggcg gtggtgaccg    12420

agaagtatga ggacgatcgc aggaagtcct tcaaaaaaat cggctccttc agcctcgaac    12480

agctccagga gtatgccgat gcggatctgt ccgtcgtcga gaagctgaag gaaatcatca    12540

ttcagaaggt cgacgagatc tataaagtgt acgggtccag cgagaagctg ttcgacgccg    12600

actttgtgct cgagaagtcc ctcaaaaaga atgacgccgt ggtggccatt atgaaagacc    12660

tgctcgactc cgtgaagtcc ttcgaaaatt acattaaagc gttctttggg gaggggaagg    12720

aaactaacag ggatgagtcc ttctatggcg actttgtcct cgcgtacgac atcctgctga    12780

aggtcgacca catttacgac gcgatccgca actacgtgac acagaagccg tactccaaag    12840

acaagttcaa gctgtacttc cagaacccgc aatttatggg gggctgggac aaggataaag    12900

agacagacta ccgcgcgaca attctccgct atggctccaa atactatctg gccatcatgg    12960

acaagaagta cgcgaagtgc ctgcagaaga tcgacaaaga cgacgtcaat ggcaactatg    13020

aaaagatcaa ctacaagctg ctgccgggtc cgaacaagat gctcccgaag gtgttcttca    13080

gcaagaagtg gatggcctac tacaatccaa gcgaggatat tcagaaaatc tataaaaacg    13140

ggaccttcaa gaagggggac atgtttaacc tcaacgactg ccacaagctc attgatttct    13200

tcaaggatag catttcccgc tacccgaaat ggtccaatgc gtacgatttt aacttctccg    13260

agacagaaaa gtacaaagac atcgcgggct tttacaggga ggtggaggag caagggtata    13320

aagtttcttt tgaatccgcg agcaagaagg aagtcgacaa gctcgtcgag gagggcaagc    13380

tctacatgtt ccaaatttat aacaaggact tttccgacaa gagccatggg accccaaacc    13440

tccacaccat gtacttcaaa ctgctctttg acgagaacaa ccacgggcaa atcaggctga    13500

gcggcggcgc cgaattattc atgcgcaggg cctccctcaa gaaggaagag ctggtcgtcc    13560

atccagccaa ttccccgatc gcgaacaaga acccggacaa tccgaaaaag accaccaccc    13620

tgtcctacga cgtctacaag gacaaacgct tcagcgaaga ccagtacgaa ttacacatcc    13680

caattgcgat taataagtgc ccaaagaata tcttcaaaat taatacagag gtcagggtgc    13740

tgctcaaaca cgacgacaat ccgtatgtca tcggcattga caggggcgag cgcaatctgc    13800

tctatatcgt ggtcgtggat gggaagggca atattgtgga gcagtactcc ctgaacgaga    13860

ttatcaacaa cttcaatggg attaggatta agaccgacta tcacagcctg ctcgacaaga    13920

aagaaaaaga gaggtttgag gcccgccaaa actggacctc cattgagaat atcaaagaat    13980

taaaggccgg ctatatttcc caagtcgtcc acaagatctg cgagctggtg gagaaatatg    14040

acgccgtgat tgcgctcgaa gacttaaatt ctgggttcaa gaactcccgc gtgaaggtgg    14100

aaaaacaggt gtatcagaaa ttcgagaaaa tgctgatcga caaactcaat tatatggtgg    14160

ataagaagtc caacccgtgt gccacagggg gcgcgctgaa gggctatcag atcaccaaca    14220

agttcgagag cttcaagagc atgagcaccc agaacgggtt tattttctac atcccggcgt    14280

ggctcacctc caagattgac ccgagcaccg gcttcgtgaa cctcctgaag acaaagtata    14340

cctccattgc cgacagcaag aagtttatct cctccttcga ccgcattatg tatgtgccgg    14400

aggaggacct cttcgagttc gccctcgact acaaaaactt cagccgcaca gatgcggatt    14460

acatcaagaa gtggaagctg tactcctacg ggaacaggat ccgcatcttc aggaatccaa    14520

aaaaaaataa cgtctttgac tgggaggaag tgtgcctgac atccgcctac aaggaactgt    14580

tcaataaata cggcatcaat taccagcagg gcgacattcg cgccctcctc tgtgagcagt    14640

ccgacaaagc gttttactcc agcttcatgg ccctcatgtc cctgatgctc caaatgagga    14700

atagcatcac agggcgcacc gacgtcgact tcctcatcag cccggtgaag aactccgacg    14760

ggatctttta cgactcccgc aactatgagg cgcaagagaa tgcgatcctc ccgaagaacg    14820

ccgatgcgaa cggggcctat aatatcgcca ggaaagtgct ctgggccatc gggcagttca    14880

aaaaggcgga ggatgagaag ctcgacaagg tgaaaattgc catttccaac aaggagtggc    14940

tggagtacgc gcagacctcc gtgaagcact gaaagggctc tctgtcatga tttcatactt    15000

tcattattga gctctgtaat tacaattatg accatgagaa catctcttat tgtgtggcct    15060

tttaattgct gatgttagta ctgaaccaaa gcttatcgtg atgatgtaaa agcaataagt    15120

acttgtttgt agcttctttg tgtctccctt tgggcttaat acatctgttt agtgttgtgg    15180

ctttggcata gacttctctt ggtaataatg ccttgcaatg caaaatttca attatcaaat    15240

tctattatgt tctcacctta tggtaacagc ttaccctgtg gaagatgaga ttcttgagtt    15300

gagtcattgc caatttttgg cattagcttt tgaattagtg aattttgaca aaaattaccg    15360

tgacactgat tttgttgaag ctcttaagtg tagtttttac aaaatttcag tggctcgttg    15420

tgattatgtc aaactcacgg cgaatgtagt tcttacagaa tttcagtggc tccctgcagg    15480

ctcgaggtca ttcatatgct tgagaagaga gtcgggatag tccaaaataa aacaaaggta    15540

agattacctg gtcaaaagtg aaaacatcag ttaaaaggtg gtataaagta aaatatcggt    15600

aataaaaggt ggcccaaagt gaaatttact cttttctact attataaaaa ttgaggatgt    15660

ttttgtcggt actttgatac gtcatttttg tatgaattgg tttttaagtt tattcgcttt    15720

tggaaatgca tatctgtatt tgagtcgggt tttaagttcg tttgcttttg taaatacaga    15780

gggatttgta taagaaatat ctttagaaaa acccatatgc taatttgaca taatttttga    15840

gaaaaatata tattcaggcg aattctcaca atgaacaata ataagattaa aatagctttc    15900

ccccgttgca gcgcatgggt attttttcta gtaaaaataa aagataaact tagactcaaa    15960

acatttacaa aaacaacccc taaagttcct aaagcccaaa gtgctatcca cgatccatag    16020

caagcccagc ccaacccaac ccaacccaac ccaccccagt ccagccaact ggacaatagt    16080

ctccacaccc ccccactatc accgtgagtt gtccgcacgc accgcacgtc tcgcagccaa    16140

aaaaaaaaag aaagaaaaaa aagaaaaaga aaaaacagca ggtgggtccg ggtcgtgggg    16200

gccggaaacg cgaggaggat cgcgagccag cgacgaggag cttaggcctc atcgttgaag    16260

atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc atcgtggaaa    16320

aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc tccactgacg    16380

taagggatga cgcacaatcc cactatcctt cgaggcctca tcgttgaaga tgcctctgcc    16440

gacagtggtc ccaaagatgg acccccaccc acgaggagca tcgtggaaaa agaagacgtt    16500

ccaaccacgt cttcaaagca agtggattga tgtgatatct ccactgacgt aagggatgac    16560

gcacaatccc actatccttc gaagctccct ccctccgctt ccaaagaaac gccccccatc    16620

gccactatat acataccccc ccctctcctc ccatcccccc aacccttcta gaaccatctt    16680

ccacacactc aagccacact attggagaac acacagggac aacacaccat aagatccaag    16740

ggaggcctcc gccgccgccg gtaaccaccc cgcccctctc ctctttcttt ctccgttttt    16800

ttttccgtct cggtctcgat ctttggcctt ggtagtttgg gtgggcgaga ggcggcttcg    16860

tgcgcgccca gatcggtgcg cgggaggggc gggatctcgc ggctggggct ctcgccggcg    16920

tggatccggc ccggatctcg cggggaatgg ggctctcgga tgtagatctg cgatccgccg    16980

ttgttggggg agatgatggg gggtttaaaa tttccgccgt gctaaacaag atcaggaaga    17040

ggggaaaagg gcactatggt ttatattttt atatatttct gctgcttcgt caggcttaga    17100

tgtgctagat ctttctttct tctttttgtg ggtagaattt gaatccctca gcattgttca    17160

tcggtagttt ttcttttcat gatttgtgac aaatgcagcc tcgtgcggag cttttttgta    17220

ggtagaaggc ggccgcatgg cccagtctaa gcacgggttg acgaaggaga tgactatgaa    17280

gtatcgcatg gaaggctgcg ttgacggcca caaattcgtc attaccggcg agggcatcgg    17340

ctaccccttt aaggtaagtt tctgcttcta cctttgatat atatataata attatcatta    17400

attagtagta atataatatt tcaaatattt ttttcaaaat aaaagaatgt agtatatagc    17460

aattgctttt ctgtagttta taagtgtgta tattttaatt tataactttt ctaatatatg    17520

accaaaattt gttgatgtgc agggcaagca agcgataaac ctgtgcgtgg tggagggtgg    17580

ccctctgccc ttcgccgagg atatactctc agccgccttc atgtacggga atcgggtgtt    17640

cacggagtac ccgcaagaca tcgtggacta cttcaagaac tcctgccccg ccggatacac    17700

atgggaccgt tccttcctct tcgaggacgg agccgtttgc atctgcaacg cggacatcac    17760

cgtgtccgtc gaggagaact gcatgtacca cgagtcaaag ttctatggag tgaacttccc    17820

ggccgatggt cccgtgatga agaaaatgac ggacaactgg gagccgtcgt gcgagaaaat    17880

cattcccgtc ccaaaacagg gaatcctcaa gggcgacgtg tcgatgtacc tacttctcaa    17940

ggacggtgga cggctacggt gccagttcga cactgtttac aaggcgaagt cggtgccgag    18000

gaagatgccg gactggcact ttatccagca caagctgaca agggaggaca gaagcgacgc    18060

taagaaccag aaatggcacc tcaccgagca cgccatcgcc agtggctctg cgctgcccgg    18120

gtgaccctgc aatgtgaccc tagacttgtc catcttctgg attggccaac ttaattaatg    18180

tatgaaataa aaggatgcac acatagtgac atgctaatca ctataatgtg ggcatcaaag    18240

ttgtgtgtta tgtgtaatta ctaattatct gaataagaga aagagatcat ccatatttct    18300

tatcctaaat gaatgtcacg tgtctttata attctttgat gaaccagatg cattttatta    18360

accaattcca tatacatata aatattaatc atatataatt aatatcaatt gggttagcaa    18420

aacaaatcta gtctaggtgt gttttgctaa ttattggggg atagtgcaaa aagaaatcta    18480

cgttctcaat aattcagata gaaaacttaa taaagtgaga taatttacat agattgcttt    18540

tatcctttga tatatgtgaa accatgcatg atataaggaa aatagataga gaaataattt    18600

tttacatcgt tgaatatgta aacaatttaa ttcaagaagc taggaatata aatattgagg    18660

agtttatgat tattattatt attttgatgt tcaatgaagt tttttttaat ttcatatgaa    18720

gtatacaaaa attcttcata gatttttgtt tctatgccgt agttatcttt aatatatttg    18780

tggttgaaga aatttattgc tagaaacgaa tggattgtca attttttttt aaagcaaata    18840

tatatgaaat tatactgtat attattttag tcatgattaa aatgtggcct taattgaatc    18900

atctttctca ttcatttttt caaaagcata tcaggatgat tgatatttat ctattttaaa    18960

aattaattta agggttcaaa ttaaatttaa cttaaaagtg tcctaaccgt agttaaaggt    19020

ttactttaaa aaaatactat gaaaaatcta atcttctatg aatcgagggc ccttagctag    19080

ttag                                                                 19084


<210>  92
<211>  19084
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3588 Full plasmid sequence

<400>  92
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt tgtaaccaac      480

atcccctgat gataatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggaaagtatt ttcggtcttc ccatatgtat ggcagatgca     6240

ggaaaaaaat ctctcccatt ggtagacatg aacagattca aaacggataa atgcacttgt     6300

aattcattca ttgcataatc ggatttggca tttgtaattt attcattgca atttccaatc     6360

aacatctgcg aatcgtacaa gtatcgaaaa tatatggtca gatcgaatag atttttggtg     6420

accttgataa cggccttaga aaaattattc ttaacctgtt ttggttttaa actaaaagat     6480

aagtagaatt tatttctcat gcttacacag aacaaataat gattaaatta gtagttttat     6540

taaagacaaa gttcgaattc gattctttgg tattttattt taggggaaat aaattatatc     6600

gattcactta aaaaattctc gataaataaa aaccacaatt ataccttatc gatttacttt     6660

taaaatttta actttcataa aaccaaaaat aaaaacaaac caccgaatat taaagcactc     6720

ggatttgatt ctatgttgtc aaagcaagtt tattttagca aaattgaaga ttcttgcata     6780

gtcacgaaca catcaaaaca gaggaagaag agcaaacagc cgatcgttaa aaaatccaac     6840

ccaaaatttg aacacaaatt atagtaaaag caaaccaagc caaaatttga acacaaatta     6900

taaagaaaaa gcaaaccaag ccaaaaattg aacactacaa atagaaagtt gacatttaat     6960

aaaccaaagc aacacaacgc agcaaagtcc tgaaactcgc tgcgcttaac aaaaatgtaa     7020

tcaggggttc cgacaaacac aacacattaa aacacagata aataaaagca attttgccac     7080

cgtcgatcaa gaacccagtt ctgggaacaa cagttgcgag atgatggtgg agacttcaaa     7140

ctttgtccga aaaacaagct acctagaaaa gaagacacaa gagtacagaa aagaaaccaa     7200

cattgattgt agccaacatt ccctgatgaa ccagcccgca cgattcattt gccgactacc     7260

ttggtgatct cgcctttcac gtagtggaca aattcttcca actgatctgc gcgcgaggcc     7320

aagcgatctt cttcttgtcc aagataagcc tgtctagctt caagtatgac gggctgatac     7380

tgggccggca ggcgctccat tgcccagtcg gcagcgacat ccttcggcgc gattttgccg     7440

gttactgcgc tgtaccaaat gcgggacaac gtaagcacta catttcgctc atcgccagcc     7500

cagtcgggcg gcgagttcca tagcgttaag gtttcattta gcgcctcaaa tagatcctgt     7560

tcaggaaccg gatcaaagag ttcctccgcc gctggaccta ccaaggcaac gctatgttct     7620

cttgcttttg tcagcaagat agccagatca atgtcgatcg tggctggctc gaagatacct     7680

gcaagaatgt cattgcgctg ccattctcca aattgcagtt cgcgcttagc tggataacgc     7740

cacggaatga tgtcgtcgtg cacaacaatg gtgacttcta cagcgcggag aatctcgctc     7800

tctccagggg aagccgaagt ttccaaaagg tcgttgatca aagctcgccg cgttgtttca     7860

tcaagcctta cggtcaccgt aaccagcaaa tcaatatcac tgtgtggctt caggccgcca     7920

tccactgcgg agccgtacaa atgtacggcc agcaacgtcg gttcgagatg gcgctcgatg     7980

acgccaacta cctctgatag ttgagtcgat acttcggcga tcaccgcttc ccccatgcac     8040

gccgtggaaa cagaagacat gaccttaaga ggacgaagct cagagccaat taacgtcatc     8100

ccactcttct tcaatcccca cgacgacgaa atcggataag ctcgtggatg ctgctgcgtc     8160

ttcagagaaa ccgataaggg agatttgcgt tgactggatt tcgagagatt ggagataaga     8220

gatgggttct gcacaccatt gcagattctg ctaacttgcg ccattggtcc agggttagac     8280

tcaacatcac cggcaagctt caagaggtca aaattcagta attgagttgc cacttcatca     8340

gcagcatttg acttcttctt ctgggcagcc ttggtgacct tggctccggt aggatccttc     8400

ttctcaacgt tcttgatgac tcccacagca acagtttgac gcatgtccct aacagcaaac     8460

ctaccaagtg gaggatactc ggagaaagtt tcaacaacca tgggtttggt tggaatcatc     8520

ttaacaaaac cagcatcacc gttcttcaaa aacttgggct ccttctcaag ctctttgccg     8580

gatcgcctgt caatcttggt catgagttca gcaaacttga cagcaatgtg agaagtgtgg     8640

cagtcgagga caggggcata gccatttcca atctgaccag ggtggttcat gatgatgact     8700

tgggctgtga agttagcagc ctcctttgca gggtcatcct ttgagtttga ggcaacataa     8760

ccacgcttca aatccttaac agcaacattc ttaacattga atcccacatt gtcaccagga     8820

tgtgcctctg taagagattc atggtgcatc tccacagact tgacttcagt tgtcagtcca     8880

gttggtgcaa aagtcaccac cattccaggc ttcaagacac cggtctcaac acgtcccact     8940

ggcacagttc caatacctcc aatcttgtac acatcctgaa ggggaagcct gaggggcttg     9000

tcagagggcc tcttgggctc actaatctgg tcaagtgcat caagcagagt tggacccttg     9060

taccagtcaa ggtttgtgga cctctcaatc atgttgtctc cctcaaaacc agagatagga     9120

acaaaaggaa tcttgtcagg gttgtatcct actttcttca agtaggaaga gacttccttc     9180

acaatttcat catacctggc cttggaatac ttgggtgtag tagcatccat ctgttgcaaa     9240

atgggacaag aacattaatt aaaataaaat aatctaataa aatgaaaggg gccttaaaag     9300

tcgagacata atttactttg ttacagcagc aaatcatctg tttcacacca acctaggctg     9360

gcagcacatc ccccgttcgc gagctggcgt aacagcgaag aggcccgggc gcgccactgt     9420

taataatttt taaacgtcag cgcactaaaa aaacgaaaag acggacacgt gaaaataaaa     9480

aacacacact agtttatgac gcaatactat tttacttatg atttgggtac attagacaaa     9540

accgtgaaag agatgtatca gctatgaaac ctgtatactt caatacagag acttactcat     9600

atcggatacg tacgcacgaa gtatcatatt aattatttta atttttaata aatattttat     9660

cggatactta tgtgatactc tacatataca caaggatatt tctaagatac tttatagata     9720

cgtatcctag aaaaacatga agagtaaaaa agtgagacaa tgttgtaaaa attcattata     9780

aatgtatatg attcaatttt agatatgcat cagtataatt gattctcgat gaaacactta     9840

aaattatatt tcttgtggaa gaacgtagcg agagaggtga ttcagttaga caacattaaa     9900

taaaattaat gttaagttct tttaatgatg tttctctcaa tatcacatca tatgaaaatg     9960

taatatgatt tataagaaaa tttttaaaaa atttatttta ataatcacat gtactatttt    10020

ttaaaaattg tatcttttat aataatacaa taataaagag taatcagtgt taatttttct    10080

tcaaatataa gttttattat aaatcattgt taacgtatca taagtcatta ccgtatcgta    10140

tcttaatttt tttttaaaaa ccgctaattc acgtacccgt attgtattgt acccgcacct    10200

gtatcacaat cgatcttagt tagaagaatt gtctcgaggc ggtgcaagac agcatataat    10260

agacgtggac tctcttatac caaacgttgt cgtatcacaa agggttaggt aacaagtcac    10320

agtttgtcca cgtgtcacgt tttaattgga agaggtgccg ttggcgtaat ataacagcca    10380

atcgattttt gctataaaag caaatcaggt aaactaaact tcttcattct tttcttcccc    10440

atcgctacaa aaccggttcc tttggaaaag agattcattc aaacctagca cccaattccg    10500

tttcaaggta taatctactt tctattcttc gattatttta ttattattag ctactatcgt    10560

ttaatcgatc ttttcttttg atccgtcaaa tttaaattca attagggttt tgttcttttc    10620

tttcatctga ttgaaatcct tctgaattga accgtttact tgattttact gtttattgta    10680

tgatttaatc ctttgttttt caaagacagt ctttagattg tgattagggg ttcatataaa    10740

tttttagatt tggatttttg tattgtatga ttcaaaaaat acgtccttta attagattag    10800

tacatggata ttttttaccc gatttattga ttgtcaggga gaatttgatg agcaagtttt    10860

tttgatgtct gttgtaaatt gaattgatta taattgctga tctgctgctt ccagttttca    10920

taacccatat tcttttaacc ttgttgtaca cacaatgaaa aattggtgat tgattcattt    10980

gtttttcttt gttttggatt atacagggta tggcgccgcc gcctgccctc cctccaaaga    11040

ggcgaagaag tggtggatct tccggggggt ccccccctcc tgctttacct ccaaaaagac    11100

gtcgttctgg tggttcaagt ggaggttctc cacctcctgc acttcctccc aagagaagaa    11160

ggagcggcgg cagctcagga ggatcaccac caccagcttt gccacccaaa aggcgccggg    11220

gctcctccga gacaccaggc acctccgaga gcgcgacgcc cgagggcggc tccggcggct    11280

ccggcagctc caagctggag aagtttacaa actgttacag cctctccaaa accctcaggt    11340

ttaaagcgat cccggtgggc aagacccagg agaacatcga caacaagagg ctcctggtgg    11400

aagacgagaa gcgcgccgaa gactacaagg gcgtgaagaa gctgctcgat aggtactacc    11460

tcagctttat taacgacgtg ctgcacagca tcaaactcaa gaatctcaac aactacatct    11520

ccctcttccg caaaaagacc cgcaccgaga aggagaacaa ggagctggag aacctggaga    11580

tcaacctccg caaggaaatc gccaaagcgt tcaagggcaa tgaagggtac aagagcctct    11640

tcaagaaaga catcatcgaa actatcctcc cagagtttct cgatgacaag gacgagatcg    11700

cgctggtgaa ctcctttaac gggttcacaa ccgcgtttac cggcttcttt gataacaggg    11760

aaaatatgtt ctccgaggag gccaagtcca ccagcatcgc cttcaggtgt atcaacgaga    11820

acctcacccg ctacatttcc aatatggaca ttttcgagaa ggtggatgcg atcttcgata    11880

agcacgaggt gcaggagatc aaagagaaga ttctcaattc cgattatgac gtcgaggatt    11940

tcttcgaagg ggagttcttt aattttgtgc tcacacaaga gggcattgac gtgtacaacg    12000

cgattatcgg gggcttcgtc acagagtccg gggagaagat taaggggctg aatgagtaca    12060

tcaatctgta caatcagaag accaagcaga aactgccgaa attcaagccg ctctacaagc    12120

aagtcctgtc cgatagggaa agcctctcct tctacggcga gggctatacc agcgacgagg    12180

aggtgctgga agtcttccgc aacacactga ataagaatag cgagattttc tcctccatca    12240

agaagctcga gaagctcttt aagaactttg acgagtacag ctccgccggg attttcgtga    12300

agaacgggcc ggcgatcagc accatctcca aggacatctt tggcgagtgg aacgtcatca    12360

gggacaagtg gaacgccgag tacgacgaca tccacctgaa gaagaaggcg gtggtgaccg    12420

agaagtatga ggacgatcgc aggaagtcct tcaaaaaaat cggctccttc agcctcgaac    12480

agctccagga gtatgccgat gcggatctgt ccgtcgtcga gaagctgaag gaaatcatca    12540

ttcagaaggt cgacgagatc tataaagtgt acgggtccag cgagaagctg ttcgacgccg    12600

actttgtgct cgagaagtcc ctcaaaaaga atgacgccgt ggtggccatt atgaaagacc    12660

tgctcgactc cgtgaagtcc ttcgaaaatt acattaaagc gttctttggg gaggggaagg    12720

aaactaacag ggatgagtcc ttctatggcg actttgtcct cgcgtacgac atcctgctga    12780

aggtcgacca catttacgac gcgatccgca actacgtgac acagaagccg tactccaaag    12840

acaagttcaa gctgtacttc cagaacccgc aatttatggg gggctgggac aaggataaag    12900

agacagacta ccgcgcgaca attctccgct atggctccaa atactatctg gccatcatgg    12960

acaagaagta cgcgaagtgc ctgcagaaga tcgacaaaga cgacgtcaat ggcaactatg    13020

aaaagatcaa ctacaagctg ctgccgggtc cgaacaagat gctcccgaag gtgttcttca    13080

gcaagaagtg gatggcctac tacaatccaa gcgaggatat tcagaaaatc tataaaaacg    13140

ggaccttcaa gaagggggac atgtttaacc tcaacgactg ccacaagctc attgatttct    13200

tcaaggatag catttcccgc tacccgaaat ggtccaatgc gtacgatttt aacttctccg    13260

agacagaaaa gtacaaagac atcgcgggct tttacaggga ggtggaggag caagggtata    13320

aagtttcttt tgaatccgcg agcaagaagg aagtcgacaa gctcgtcgag gagggcaagc    13380

tctacatgtt ccaaatttat aacaaggact tttccgacaa gagccatggg accccaaacc    13440

tccacaccat gtacttcaaa ctgctctttg acgagaacaa ccacgggcaa atcaggctga    13500

gcggcggcgc cgaattattc atgcgcaggg cctccctcaa gaaggaagag ctggtcgtcc    13560

atccagccaa ttccccgatc gcgaacaaga acccggacaa tccgaaaaag accaccaccc    13620

tgtcctacga cgtctacaag gacaaacgct tcagcgaaga ccagtacgaa ttacacatcc    13680

caattgcgat taataagtgc ccaaagaata tcttcaaaat taatacagag gtcagggtgc    13740

tgctcaaaca cgacgacaat ccgtatgtca tcggcattga caggggcgag cgcaatctgc    13800

tctatatcgt ggtcgtggat gggaagggca atattgtgga gcagtactcc ctgaacgaga    13860

ttatcaacaa cttcaatggg attaggatta agaccgacta tcacagcctg ctcgacaaga    13920

aagaaaaaga gaggtttgag gcccgccaaa actggacctc cattgagaat atcaaagaat    13980

taaaggccgg ctatatttcc caagtcgtcc acaagatctg cgagctggtg gagaaatatg    14040

acgccgtgat tgcgctcgaa gacttaaatt ctgggttcaa gaactcccgc gtgaaggtgg    14100

aaaaacaggt gtatcagaaa ttcgagaaaa tgctgatcga caaactcaat tatatggtgg    14160

ataagaagtc caacccgtgt gccacagggg gcgcgctgaa gggctatcag atcaccaaca    14220

agttcgagag cttcaagagc atgagcaccc agaacgggtt tattttctac atcccggcgt    14280

ggctcacctc caagattgac ccgagcaccg gcttcgtgaa cctcctgaag acaaagtata    14340

cctccattgc cgacagcaag aagtttatct cctccttcga ccgcattatg tatgtgccgg    14400

aggaggacct cttcgagttc gccctcgact acaaaaactt cagccgcaca gatgcggatt    14460

acatcaagaa gtggaagctg tactcctacg ggaacaggat ccgcatcttc aggaatccaa    14520

aaaaaaataa cgtctttgac tgggaggaag tgtgcctgac atccgcctac aaggaactgt    14580

tcaataaata cggcatcaat taccagcagg gcgacattcg cgccctcctc tgtgagcagt    14640

ccgacaaagc gttttactcc agcttcatgg ccctcatgtc cctgatgctc caaatgagga    14700

atagcatcac agggcgcacc gacgtcgact tcctcatcag cccggtgaag aactccgacg    14760

ggatctttta cgactcccgc aactatgagg cgcaagagaa tgcgatcctc ccgaagaacg    14820

ccgatgcgaa cggggcctat aatatcgcca ggaaagtgct ctgggccatc gggcagttca    14880

aaaaggcgga ggatgagaag ctcgacaagg tgaaaattgc catttccaac aaggagtggc    14940

tggagtacgc gcagacctcc gtgaagcact gaaagggctc tctgtcatga tttcatactt    15000

tcattattga gctctgtaat tacaattatg accatgagaa catctcttat tgtgtggcct    15060

tttaattgct gatgttagta ctgaaccaaa gcttatcgtg atgatgtaaa agcaataagt    15120

acttgtttgt agcttctttg tgtctccctt tgggcttaat acatctgttt agtgttgtgg    15180

ctttggcata gacttctctt ggtaataatg ccttgcaatg caaaatttca attatcaaat    15240

tctattatgt tctcacctta tggtaacagc ttaccctgtg gaagatgaga ttcttgagtt    15300

gagtcattgc caatttttgg cattagcttt tgaattagtg aattttgaca aaaattaccg    15360

tgacactgat tttgttgaag ctcttaagtg tagtttttac aaaatttcag tggctcgttg    15420

tgattatgtc aaactcacgg cgaatgtagt tcttacagaa tttcagtggc tccctgcagg    15480

ctcgaggtca ttcatatgct tgagaagaga gtcgggatag tccaaaataa aacaaaggta    15540

agattacctg gtcaaaagtg aaaacatcag ttaaaaggtg gtataaagta aaatatcggt    15600

aataaaaggt ggcccaaagt gaaatttact cttttctact attataaaaa ttgaggatgt    15660

ttttgtcggt actttgatac gtcatttttg tatgaattgg tttttaagtt tattcgcttt    15720

tggaaatgca tatctgtatt tgagtcgggt tttaagttcg tttgcttttg taaatacaga    15780

gggatttgta taagaaatat ctttagaaaa acccatatgc taatttgaca taatttttga    15840

gaaaaatata tattcaggcg aattctcaca atgaacaata ataagattaa aatagctttc    15900

ccccgttgca gcgcatgggt attttttcta gtaaaaataa aagataaact tagactcaaa    15960

acatttacaa aaacaacccc taaagttcct aaagcccaaa gtgctatcca cgatccatag    16020

caagcccagc ccaacccaac ccaacccaac ccaccccagt ccagccaact ggacaatagt    16080

ctccacaccc ccccactatc accgtgagtt gtccgcacgc accgcacgtc tcgcagccaa    16140

aaaaaaaaag aaagaaaaaa aagaaaaaga aaaaacagca ggtgggtccg ggtcgtgggg    16200

gccggaaacg cgaggaggat cgcgagccag cgacgaggag cttaggcctc atcgttgaag    16260

atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc atcgtggaaa    16320

aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc tccactgacg    16380

taagggatga cgcacaatcc cactatcctt cgaggcctca tcgttgaaga tgcctctgcc    16440

gacagtggtc ccaaagatgg acccccaccc acgaggagca tcgtggaaaa agaagacgtt    16500

ccaaccacgt cttcaaagca agtggattga tgtgatatct ccactgacgt aagggatgac    16560

gcacaatccc actatccttc gaagctccct ccctccgctt ccaaagaaac gccccccatc    16620

gccactatat acataccccc ccctctcctc ccatcccccc aacccttcta gaaccatctt    16680

ccacacactc aagccacact attggagaac acacagggac aacacaccat aagatccaag    16740

ggaggcctcc gccgccgccg gtaaccaccc cgcccctctc ctctttcttt ctccgttttt    16800

ttttccgtct cggtctcgat ctttggcctt ggtagtttgg gtgggcgaga ggcggcttcg    16860

tgcgcgccca gatcggtgcg cgggaggggc gggatctcgc ggctggggct ctcgccggcg    16920

tggatccggc ccggatctcg cggggaatgg ggctctcgga tgtagatctg cgatccgccg    16980

ttgttggggg agatgatggg gggtttaaaa tttccgccgt gctaaacaag atcaggaaga    17040

ggggaaaagg gcactatggt ttatattttt atatatttct gctgcttcgt caggcttaga    17100

tgtgctagat ctttctttct tctttttgtg ggtagaattt gaatccctca gcattgttca    17160

tcggtagttt ttcttttcat gatttgtgac aaatgcagcc tcgtgcggag cttttttgta    17220

ggtagaaggc ggccgcatgg cccagtctaa gcacgggttg acgaaggaga tgactatgaa    17280

gtatcgcatg gaaggctgcg ttgacggcca caaattcgtc attaccggcg agggcatcgg    17340

ctaccccttt aaggtaagtt tctgcttcta cctttgatat atatataata attatcatta    17400

attagtagta atataatatt tcaaatattt ttttcaaaat aaaagaatgt agtatatagc    17460

aattgctttt ctgtagttta taagtgtgta tattttaatt tataactttt ctaatatatg    17520

accaaaattt gttgatgtgc agggcaagca agcgataaac ctgtgcgtgg tggagggtgg    17580

ccctctgccc ttcgccgagg atatactctc agccgccttc atgtacggga atcgggtgtt    17640

cacggagtac ccgcaagaca tcgtggacta cttcaagaac tcctgccccg ccggatacac    17700

atgggaccgt tccttcctct tcgaggacgg agccgtttgc atctgcaacg cggacatcac    17760

cgtgtccgtc gaggagaact gcatgtacca cgagtcaaag ttctatggag tgaacttccc    17820

ggccgatggt cccgtgatga agaaaatgac ggacaactgg gagccgtcgt gcgagaaaat    17880

cattcccgtc ccaaaacagg gaatcctcaa gggcgacgtg tcgatgtacc tacttctcaa    17940

ggacggtgga cggctacggt gccagttcga cactgtttac aaggcgaagt cggtgccgag    18000

gaagatgccg gactggcact ttatccagca caagctgaca agggaggaca gaagcgacgc    18060

taagaaccag aaatggcacc tcaccgagca cgccatcgcc agtggctctg cgctgcccgg    18120

gtgaccctgc aatgtgaccc tagacttgtc catcttctgg attggccaac ttaattaatg    18180

tatgaaataa aaggatgcac acatagtgac atgctaatca ctataatgtg ggcatcaaag    18240

ttgtgtgtta tgtgtaatta ctaattatct gaataagaga aagagatcat ccatatttct    18300

tatcctaaat gaatgtcacg tgtctttata attctttgat gaaccagatg cattttatta    18360

accaattcca tatacatata aatattaatc atatataatt aatatcaatt gggttagcaa    18420

aacaaatcta gtctaggtgt gttttgctaa ttattggggg atagtgcaaa aagaaatcta    18480

cgttctcaat aattcagata gaaaacttaa taaagtgaga taatttacat agattgcttt    18540

tatcctttga tatatgtgaa accatgcatg atataaggaa aatagataga gaaataattt    18600

tttacatcgt tgaatatgta aacaatttaa ttcaagaagc taggaatata aatattgagg    18660

agtttatgat tattattatt attttgatgt tcaatgaagt tttttttaat ttcatatgaa    18720

gtatacaaaa attcttcata gatttttgtt tctatgccgt agttatcttt aatatatttg    18780

tggttgaaga aatttattgc tagaaacgaa tggattgtca attttttttt aaagcaaata    18840

tatatgaaat tatactgtat attattttag tcatgattaa aatgtggcct taattgaatc    18900

atctttctca ttcatttttt caaaagcata tcaggatgat tgatatttat ctattttaaa    18960

aattaattta agggttcaaa ttaaatttaa cttaaaagtg tcctaaccgt agttaaaggt    19020

ttactttaaa aaaatactat gaaaaatcta atcttctatg aatcgagggc ccttagctag    19080

ttag                                                                 19084


<210>  93
<211>  19080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3767 Full plasmid sequence

<400>  93
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt gtgtgatgtt      480

cgatgttgga tttaatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggttaggatt ttttttcacg aaattgcttc ttgaaattac     6240

gtgatggatt ttgattctga tttatcttgt gattgttgac tctacagatg cagatcttcg     6300

tcaagaccct caccggaaag accatcaccc ttgaggtgga aagctctgac accatcgaca     6360

acgtcaaggc caagatccag gacaaggaag gaattccccc ggatcagcaa cgtctcatct     6420

tcgccggaaa gcagctcgag gacggccgta ccctcgccga ctacaacatc cagaaggagt     6480

caacccttca ccttgtcctt cgtctccgtg gtggcatgca gatcttcgtc aagactctca     6540

ctggcaaaac cataacccta gaggtcgaaa gctctgacac cattgacaac gtcaaggcca     6600

agatccagga caaggaggga atccccccag accagcaacg tctcatcttc gccggaaagc     6660

aacttgagga cgggcgcacc ctcgccgact acaacatcca gaaggaatca acccttcacc     6720

tcgtcctccg tctccgtggt ggcatgcaga tcttcgttaa gaccctcacc ggcaagacta     6780

taaccctaga agtcgagagc tccgacacca tcgacaacgt caaggctaag atccaggaca     6840

aggagggtat ccccccagac cagcagaggc tgatcttcgc cggcaagcag ctcgaggacg     6900

gacgtaccct tgctgactac aacatccaga aggagtcaac tctccacttg gtgttgcgtc     6960

ttcgtggtgg tatgcagatc ttcgtcaaga cccttacggg taagactatt accctcgagg     7020

tggagagctc cgacaccatt gacaatgtga aggcgaagat ccaggacaag gaaggaatcc     7080

caccggacca gcagaggctt atttttgctg gcaaacagct agaggatgga aggaccctcg     7140

ctgactacaa catccagaag gagtcaactc tgcacttggt gttgcgtctt cgtggggggt     7200

tttcaaatgc tgctgatgaa gtggcaactc aattactgaa ttttgacctc ttgaagcttg     7260

ccggtgatgt tgagtctaac cctggaccaa tggcgcaagt tagcagaatc tgcaatggtg     7320

tgcagaaccc atctcttatc tccaatctct cgaaatccag tcaacgcaaa tctcccttat     7380

cggtttctct gaagacgcag cagcatccac gagcttatcc gatttcgtcg tcgtggggat     7440

tgaagaagag tgggatgacg ttaattggct ctgagcttcg tcctcttaag gtcatgtctt     7500

ctgtttccac ggcgtgcatg ggggaagcgg tgatcgccga agtatcgact caactatcag     7560

aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta catttgtacg     7620

gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg gttacggtga     7680

ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg gaaacttcgg     7740

cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt gtgcacgacg     7800

acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa tggcagcgca     7860

atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg gctatcttgc     7920

tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag gaactctttg     7980

atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg ctatggaact     8040

cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc cgcatttggt     8100

acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg gcaatggagc     8160

gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat cttggacaag     8220

aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac tacgtgaaag     8280

gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg atgtctgatg     8340

ttggattttc ccagacattt taagaagaaa tgtgatgtgt aatgggtctg taatgacctt     8400

tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact actgtttgtt     8460

atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg tgtttgaatt     8520

ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc atgcttatca     8580

cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga attattagat     8640

tttggtatta taggttaaag atatttatta ggtagggaga actcttggat tagattctaa     8700

agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat gatccctagt     8760

ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg tgaagcatat     8820

ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta attggcttgc     8880

ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc aattttagtt     8940

atgcaatctt tctgcttcag gtagtccttg tcttacagaa agcacattga gatgatcccc     9000

acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt aaaagatgta     9060

atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc aaaaaatacc     9120

aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat ttgattacca     9180

aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac tggaccccaa     9240

attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt taaaatccca     9300

tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacct aggctggcag     9360

cacatccccc gttcgcgagc tggcgtaaca gcgaagaggc ccgggcgcgc cactgttaat     9420

aatttttaaa cgtcagcgca ctaaaaaaac gaaaagacgg acacgtgaaa ataaaaaaca     9480

cacactagtt tatgacgcaa tactatttta cttatgattt gggtacatta gacaaaaccg     9540

tgaaagagat gtatcagcta tgaaacctgt atacttcaat acagagactt actcatatcg     9600

gatacgtacg cacgaagtat catattaatt attttaattt ttaataaata ttttatcgga     9660

tacttatgtg atactctaca tatacacaag gatatttcta agatacttta tagatacgta     9720

tcctagaaaa acatgaagag taaaaaagtg agacaatgtt gtaaaaattc attataaatg     9780

tatatgattc aattttagat atgcatcagt ataattgatt ctcgatgaaa cacttaaaat     9840

tatatttctt gtggaagaac gtagcgagag aggtgattca gttagacaac attaaataaa     9900

attaatgtta agttctttta atgatgtttc tctcaatatc acatcatatg aaaatgtaat     9960

atgatttata agaaaatttt taaaaaattt attttaataa tcacatgtac tattttttaa    10020

aaattgtatc ttttataata atacaataat aaagagtaat cagtgttaat ttttcttcaa    10080

atataagttt tattataaat cattgttaac gtatcataag tcattaccgt atcgtatctt    10140

aatttttttt taaaaaccgc taattcacgt acccgtattg tattgtaccc gcacctgtat    10200

cacaatcgat cttagttaga agaattgtct cgaggcggtg caagacagca tataatagac    10260

gtggactctc ttataccaaa cgttgtcgta tcacaaaggg ttaggtaaca agtcacagtt    10320

tgtccacgtg tcacgtttta attggaagag gtgccgttgg cgtaatataa cagccaatcg    10380

atttttgcta taaaagcaaa tcaggtaaac taaacttctt cattcttttc ttccccatcg    10440

ctacaaaacc ggttcctttg gaaaagagat tcattcaaac ctagcaccca attccgtttc    10500

aaggtataat ctactttcta ttcttcgatt attttattat tattagctac tatcgtttaa    10560

tcgatctttt cttttgatcc gtcaaattta aattcaatta gggttttgtt cttttctttc    10620

atctgattga aatccttctg aattgaaccg tttacttgat tttactgttt attgtatgat    10680

ttaatccttt gtttttcaaa gacagtcttt agattgtgat taggggttca tataaatttt    10740

tagatttgga tttttgtatt gtatgattca aaaaatacgt cctttaatta gattagtaca    10800

tggatatttt ttacccgatt tattgattgt cagggagaat ttgatgagca agtttttttg    10860

atgtctgttg taaattgaat tgattataat tgctgatctg ctgcttccag ttttcataac    10920

ccatattctt ttaaccttgt tgtacacaca atgaaaaatt ggtgattgat tcatttgttt    10980

ttctttgttt tggattatac agggtatggc gccgccgcct gccctccctc caaagaggcg    11040

aagaagtggt ggatcttccg gggggtcccc ccctcctgct ttacctccaa aaagacgtcg    11100

ttctggtggt tcaagtggag gttctccacc tcctgcactt cctcccaaga gaagaaggag    11160

cggcggcagc tcaggaggat caccaccacc agctttgcca cccaaaaggc gccggggctc    11220

ctccgagaca ccaggcacct ccgagagcgc gacgcccgag ggcggctccg gcggctccgg    11280

cagctccaag ctggagaagt ttacaaactg ttacagcctc tccaaaaccc tcaggtttaa    11340

agcgatcccg gtgggcaaga cccaggagaa catcgacaac aagaggctcc tggtggaaga    11400

cgagaagcgc gccgaagact acaagggcgt gaagaagctg ctcgataggt actacctcag    11460

ctttattaac gacgtgctgc acagcatcaa actcaagaat ctcaacaact acatctccct    11520

cttccgcaaa aagacccgca ccgagaagga gaacaaggag ctggagaacc tggagatcaa    11580

cctccgcaag gaaatcgcca aagcgttcaa gggcaatgaa gggtacaaga gcctcttcaa    11640

gaaagacatc atcgaaacta tcctcccaga gtttctcgat gacaaggacg agatcgcgct    11700

ggtgaactcc tttaacgggt tcacaaccgc gtttaccggc ttctttgata acagggaaaa    11760

tatgttctcc gaggaggcca agtccaccag catcgccttc aggtgtatca acgagaacct    11820

cacccgctac atttccaata tggacatttt cgagaaggtg gatgcgatct tcgataagca    11880

cgaggtgcag gagatcaaag agaagattct caattccgat tatgacgtcg aggatttctt    11940

cgaaggggag ttctttaatt ttgtgctcac acaagagggc attgacgtgt acaacgcgat    12000

tatcgggggc ttcgtcacag agtccgggga gaagattaag gggctgaatg agtacatcaa    12060

tctgtacaat cagaagacca agcagaaact gccgaaattc aagccgctct acaagcaagt    12120

cctgtccgat agggaaagcc tctccttcta cggcgagggc tataccagcg acgaggaggt    12180

gctggaagtc ttccgcaaca cactgaataa gaatagcgag attttctcct ccatcaagaa    12240

gctcgagaag ctctttaaga actttgacga gtacagctcc gccgggattt tcgtgaagaa    12300

cgggccggcg atcagcacca tctccaagga catctttggc gagtggaacg tcatcaggga    12360

caagtggaac gccgagtacg acgacatcca cctgaagaag aaggcggtgg tgaccgagaa    12420

gtatgaggac gatcgcagga agtccttcaa aaaaatcggc tccttcagcc tcgaacagct    12480

ccaggagtat gccgatgcgg atctgtccgt cgtcgagaag ctgaaggaaa tcatcattca    12540

gaaggtcgac gagatctata aagtgtacgg gtccagcgag aagctgttcg acgccgactt    12600

tgtgctcgag aagtccctca aaaagaatga cgccgtggtg gccattatga aagacctgct    12660

cgactccgtg aagtccttcg aaaattacat taaagcgttc tttggggagg ggaaggaaac    12720

taacagggat gagtccttct atggcgactt tgtcctcgcg tacgacatcc tgctgaaggt    12780

cgaccacatt tacgacgcga tccgcaacta cgtgacacag aagccgtact ccaaagacaa    12840

gttcaagctg tacttccaga acccgcaatt tatggggggc tgggacaagg ataaagagac    12900

agactaccgc gcgacaattc tccgctatgg ctccaaatac tatctggcca tcatggacaa    12960

gaagtacgcg aagtgcctgc agaagatcga caaagacgac gtcaatggca actatgaaaa    13020

gatcaactac aagctgctgc cgggtccgaa caagatgctc ccgaaggtgt tcttcagcaa    13080

gaagtggatg gcctactaca atccaagcga ggatattcag aaaatctata aaaacgggac    13140

cttcaagaag ggggacatgt ttaacctcaa cgactgccac aagctcattg atttcttcaa    13200

ggatagcatt tcccgctacc cgaaatggtc caatgcgtac gattttaact tctccgagac    13260

agaaaagtac aaagacatcg cgggctttta cagggaggtg gaggagcaag ggtataaagt    13320

ttcttttgaa tccgcgagca agaaggaagt cgacaagctc gtcgaggagg gcaagctcta    13380

catgttccaa atttataaca aggacttttc cgacaagagc catgggaccc caaacctcca    13440

caccatgtac ttcaaactgc tctttgacga gaacaaccac gggcaaatca ggctgagcgg    13500

cggcgccgaa ttattcatgc gcagggcctc cctcaagaag gaagagctgg tcgtccatcc    13560

agccaattcc ccgatcgcga acaagaaccc ggacaatccg aaaaagacca ccaccctgtc    13620

ctacgacgtc tacaaggaca aacgcttcag cgaagaccag tacgaattac acatcccaat    13680

tgcgattaat aagtgcccaa agaatatctt caaaattaat acagaggtca gggtgctgct    13740

caaacacgac gacaatccgt atgtcatcgg cattgacagg ggcgagcgca atctgctcta    13800

tatcgtggtc gtggatggga agggcaatat tgtggagcag tactccctga acgagattat    13860

caacaacttc aatgggatta ggattaagac cgactatcac agcctgctcg acaagaaaga    13920

aaaagagagg tttgaggccc gccaaaactg gacctccatt gagaatatca aagaattaaa    13980

ggccggctat atttcccaag tcgtccacaa gatctgcgag ctggtggaga aatatgacgc    14040

cgtgattgcg ctcgaagact taaattctgg gttcaagaac tcccgcgtga aggtggaaaa    14100

acaggtgtat cagaaattcg agaaaatgct gatcgacaaa ctcaattata tggtggataa    14160

gaagtccaac ccgtgtgcca cagggggcgc gctgaagggc tatcagatca ccaacaagtt    14220

cgagagcttc aagagcatga gcacccagaa cgggtttatt ttctacatcc cggcgtggct    14280

cacctccaag attgacccga gcaccggctt cgtgaacctc ctgaagacaa agtatacctc    14340

cattgccgac agcaagaagt ttatctcctc cttcgaccgc attatgtatg tgccggagga    14400

ggacctcttc gagttcgccc tcgactacaa aaacttcagc cgcacagatg cggattacat    14460

caagaagtgg aagctgtact cctacgggaa caggatccgc atcttcagga atccaaaaaa    14520

aaataacgtc tttgactggg aggaagtgtg cctgacatcc gcctacaagg aactgttcaa    14580

taaatacggc atcaattacc agcagggcga cattcgcgcc ctcctctgtg agcagtccga    14640

caaagcgttt tactccagct tcatggccct catgtccctg atgctccaaa tgaggaatag    14700

catcacaggg cgcaccgacg tcgacttcct catcagcccg gtgaagaact ccgacgggat    14760

cttttacgac tcccgcaact atgaggcgca agagaatgcg atcctcccga agaacgccga    14820

tgcgaacggg gcctataata tcgccaggaa agtgctctgg gccatcgggc agttcaaaaa    14880

ggcggaggat gagaagctcg acaaggtgaa aattgccatt tccaacaagg agtggctgga    14940

gtacgcgcag acctccgtga agcactgaaa gggctctctg tcatgatttc atactttcat    15000

tattgagctc tgtaattaca attatgacca tgagaacatc tcttattgtg tggcctttta    15060

attgctgatg ttagtactga accaaagctt atcgtgatga tgtaaaagca ataagtactt    15120

gtttgtagct tctttgtgtc tccctttggg cttaatacat ctgtttagtg ttgtggcttt    15180

ggcatagact tctcttggta ataatgcctt gcaatgcaaa atttcaatta tcaaattcta    15240

ttatgttctc accttatggt aacagcttac cctgtggaag atgagattct tgagttgagt    15300

cattgccaat ttttggcatt agcttttgaa ttagtgaatt ttgacaaaaa ttaccgtgac    15360

actgattttg ttgaagctct taagtgtagt ttttacaaaa tttcagtggc tcgttgtgat    15420

tatgtcaaac tcacggcgaa tgtagttctt acagaatttc agtggctccc tgcaggctcg    15480

aggtcattca tatgcttgag aagagagtcg ggatagtcca aaataaaaca aaggtaagat    15540

tacctggtca aaagtgaaaa catcagttaa aaggtggtat aaagtaaaat atcggtaata    15600

aaaggtggcc caaagtgaaa tttactcttt tctactatta taaaaattga ggatgttttt    15660

gtcggtactt tgatacgtca tttttgtatg aattggtttt taagtttatt cgcttttgga    15720

aatgcatatc tgtatttgag tcgggtttta agttcgtttg cttttgtaaa tacagaggga    15780

tttgtataag aaatatcttt agaaaaaccc atatgctaat ttgacataat ttttgagaaa    15840

aatatatatt caggcgaatt ctcacaatga acaataataa gattaaaata gctttccccc    15900

gttgcagcgc atgggtattt tttctagtaa aaataaaaga taaacttaga ctcaaaacat    15960

ttacaaaaac aacccctaaa gttcctaaag cccaaagtgc tatccacgat ccatagcaag    16020

cccagcccaa cccaacccaa cccaacccac cccagtccag ccaactggac aatagtctcc    16080

acaccccccc actatcaccg tgagttgtcc gcacgcaccg cacgtctcgc agccaaaaaa    16140

aaaaagaaag aaaaaaaaga aaaagaaaaa acagcaggtg ggtccgggtc gtgggggccg    16200

gaaacgcgag gaggatcgcg agccagcgac gaggagctta ggcctcatcg ttgaagatgc    16260

ctctgccgac agtggtccca aagatggacc cccacccacg aggagcatcg tggaaaaaga    16320

agacgttcca accacgtctt caaagcaagt ggattgatgt gatatctcca ctgacgtaag    16380

ggatgacgca caatcccact atccttcgag gcctcatcgt tgaagatgcc tctgccgaca    16440

gtggtcccaa agatggaccc ccacccacga ggagcatcgt ggaaaaagaa gacgttccaa    16500

ccacgtcttc aaagcaagtg gattgatgtg atatctccac tgacgtaagg gatgacgcac    16560

aatcccacta tccttcgaag ctccctccct ccgcttccaa agaaacgccc cccatcgcca    16620

ctatatacat acccccccct ctcctcccat ccccccaacc cttctagaac catcttccac    16680

acactcaagc cacactattg gagaacacac agggacaaca caccataaga tccaagggag    16740

gcctccgccg ccgccggtaa ccaccccgcc cctctcctct ttctttctcc gttttttttt    16800

ccgtctcggt ctcgatcttt ggccttggta gtttgggtgg gcgagaggcg gcttcgtgcg    16860

cgcccagatc ggtgcgcggg aggggcggga tctcgcggct ggggctctcg ccggcgtgga    16920

tccggcccgg atctcgcggg gaatggggct ctcggatgta gatctgcgat ccgccgttgt    16980

tgggggagat gatggggggt ttaaaatttc cgccgtgcta aacaagatca ggaagagggg    17040

aaaagggcac tatggtttat atttttatat atttctgctg cttcgtcagg cttagatgtg    17100

ctagatcttt ctttcttctt tttgtgggta gaatttgaat ccctcagcat tgttcatcgg    17160

tagtttttct tttcatgatt tgtgacaaat gcagcctcgt gcggagcttt tttgtaggta    17220

gaaggcggcc gcatggccca gtctaagcac gggttgacga aggagatgac tatgaagtat    17280

cgcatggaag gctgcgttga cggccacaaa ttcgtcatta ccggcgaggg catcggctac    17340

ccctttaagg taagtttctg cttctacctt tgatatatat ataataatta tcattaatta    17400

gtagtaatat aatatttcaa atattttttt caaaataaaa gaatgtagta tatagcaatt    17460

gcttttctgt agtttataag tgtgtatatt ttaatttata acttttctaa tatatgacca    17520

aaatttgttg atgtgcaggg caagcaagcg ataaacctgt gcgtggtgga gggtggccct    17580

ctgcccttcg ccgaggatat actctcagcc gccttcatgt acgggaatcg ggtgttcacg    17640

gagtacccgc aagacatcgt ggactacttc aagaactcct gccccgccgg atacacatgg    17700

gaccgttcct tcctcttcga ggacggagcc gtttgcatct gcaacgcgga catcaccgtg    17760

tccgtcgagg agaactgcat gtaccacgag tcaaagttct atggagtgaa cttcccggcc    17820

gatggtcccg tgatgaagaa aatgacggac aactgggagc cgtcgtgcga gaaaatcatt    17880

cccgtcccaa aacagggaat cctcaagggc gacgtgtcga tgtacctact tctcaaggac    17940

ggtggacggc tacggtgcca gttcgacact gtttacaagg cgaagtcggt gccgaggaag    18000

atgccggact ggcactttat ccagcacaag ctgacaaggg aggacagaag cgacgctaag    18060

aaccagaaat ggcacctcac cgagcacgcc atcgccagtg gctctgcgct gcccgggtga    18120

ccctgcaatg tgaccctaga cttgtccatc ttctggattg gccaacttaa ttaatgtatg    18180

aaataaaagg atgcacacat agtgacatgc taatcactat aatgtgggca tcaaagttgt    18240

gtgttatgtg taattactaa ttatctgaat aagagaaaga gatcatccat atttcttatc    18300

ctaaatgaat gtcacgtgtc tttataattc tttgatgaac cagatgcatt ttattaacca    18360

attccatata catataaata ttaatcatat ataattaata tcaattgggt tagcaaaaca    18420

aatctagtct aggtgtgttt tgctaattat tgggggatag tgcaaaaaga aatctacgtt    18480

ctcaataatt cagatagaaa acttaataaa gtgagataat ttacatagat tgcttttatc    18540

ctttgatata tgtgaaacca tgcatgatat aaggaaaata gatagagaaa taatttttta    18600

catcgttgaa tatgtaaaca atttaattca agaagctagg aatataaata ttgaggagtt    18660

tatgattatt attattattt tgatgttcaa tgaagttttt tttaatttca tatgaagtat    18720

acaaaaattc ttcatagatt tttgtttcta tgccgtagtt atctttaata tatttgtggt    18780

tgaagaaatt tattgctaga aacgaatgga ttgtcaattt ttttttaaag caaatatata    18840

tgaaattata ctgtatatta ttttagtcat gattaaaatg tggccttaat tgaatcatct    18900

ttctcattca ttttttcaaa agcatatcag gatgattgat atttatctat tttaaaaatt    18960

aatttaaggg ttcaaattaa atttaactta aaagtgtcct aaccgtagtt aaaggtttac    19020

tttaaaaaaa tactatgaaa aatctaatct tctatgaatc gagggccctt agctagttag    19080


<210>  94
<211>  19080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3768 Full plasmid sequence

<400>  94
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt gtgtgatgtt      480

cgatgttgga tttaatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggtaatgaca tttgtttcat gtataaacct gcgttgttat     6240

ttgtaaaaat gggattttaa cccgatcgct tttgttttta tctgttaaac ggatccgatt     6300

ctgattaatt tggggtccag tattggagca gaaaaatacc actgaatagt gtttttattt     6360

tttggtattt ggtaatcaaa tttatattgg agcagaaaaa tatcactgaa taacttgttt     6420

tttctttttg gtattttttg gggtccagta tacaaaaact tgcacaaaaa ttagggatta     6480

gtatggcatt acatctttta atgattttca agttattatt gattaggaat tttttatgtg     6540

gatctgtgtg gggatcatct caatgtgctt tctgtaagac aaggactacc tgaagcagaa     6600

agattgcata actaaaattg attaggaatt tttatgtgga cctgtgtgga tcatctaaat     6660

gtgcattccg caagccaatt aatgttccaa ctgaagcaga ttgcttacat aatttatata     6720

cgataccaaa tatgcttcac gagcataatt tttaagttgc tacctcttgg taaggggcag     6780

ctaattgaaa ctagggatca tgatctccgt ttgttcaaaa atcctttggt gtgttttcaa     6840

aatatcactt tagaatctaa tccaagagtt ctccctacct aataaatatc tttaacctat     6900

aataccaaaa tctaataatt cgtgggatga tcaccatcct tcacacaact catccctgct     6960

tttcctccgt gataagcatg aagaataaaa aacccactaa tatacgccaa ttcactggat     7020

tgagaacaaa attcaaacac aatatgccag catacagttg ataattatat atcagctcca     7080

caaattgata acaaacagta gtaacattaa tgggacaata gagttcaaca caaaccaaac     7140

ttattttcaa aggtcattac agacccatta cacatcacat ttcttcttaa aatgtctggg     7200

aaaatccaac atcagacatc acacagacat cagctccagc ttatttgccg actaccttgg     7260

tgatctcgcc tttcacgtag tggacaaatt cttccaactg atctgcgcgc gaggccaagc     7320

gatcttcttc ttgtccaaga taagcctgtc tagcttcaag tatgacgggc tgatactggg     7380

ccggcaggcg ctccattgcc cagtcggcag cgacatcctt cggcgcgatt ttgccggtta     7440

ctgcgctgta ccaaatgcgg gacaacgtaa gcactacatt tcgctcatcg ccagcccagt     7500

cgggcggcga gttccatagc gttaaggttt catttagcgc ctcaaataga tcctgttcag     7560

gaaccggatc aaagagttcc tccgccgctg gacctaccaa ggcaacgcta tgttctcttg     7620

cttttgtcag caagatagcc agatcaatgt cgatcgtggc tggctcgaag atacctgcaa     7680

gaatgtcatt gcgctgccat tctccaaatt gcagttcgcg cttagctgga taacgccacg     7740

gaatgatgtc gtcgtgcaca acaatggtga cttctacagc gcggagaatc tcgctctctc     7800

caggggaagc cgaagtttcc aaaaggtcgt tgatcaaagc tcgccgcgtt gtttcatcaa     7860

gccttacggt caccgtaacc agcaaatcaa tatcactgtg tggcttcagg ccgccatcca     7920

ctgcggagcc gtacaaatgt acggccagca acgtcggttc gagatggcgc tcgatgacgc     7980

caactacctc tgatagttga gtcgatactt cggcgatcac cgcttccccc atgcacgccg     8040

tggaaacaga agacatgacc ttaagaggac gaagctcaga gccaattaac gtcatcccac     8100

tcttcttcaa tccccacgac gacgaaatcg gataagctcg tggatgctgc tgcgtcttca     8160

gagaaaccga taagggagat ttgcgttgac tggatttcga gagattggag ataagagatg     8220

ggttctgcac accattgcag attctgctaa cttgcgccat tggtccaggg ttagactcaa     8280

catcaccggc aagcttcaag aggtcaaaat tcagtaattg agttgccact tcatcagcag     8340

catttgaaaa ccccccacga agacgcaaca ccaagtgcag agttgactcc ttctggatgt     8400

tgtagtcagc gagggtcctt ccatcctcta gctgtttgcc agcaaaaata agcctctgct     8460

ggtccggtgg gattccttcc ttgtcctgga tcttcgcctt cacattgtca atggtgtcgg     8520

agctctccac ctcgagggta atagtcttac ccgtaagggt cttgacgaag atctgcatac     8580

caccacgaag acgcaacacc aagtggagag ttgactcctt ctggatgttg tagtcagcaa     8640

gggtacgtcc gtcctcgagc tgcttgccgg cgaagatcag cctctgctgg tctgggggga     8700

taccctcctt gtcctggatc ttagccttga cgttgtcgat ggtgtcggag ctctcgactt     8760

ctagggttat agtcttgccg gtgagggtct taacgaagat ctgcatgcca ccacggagac     8820

ggaggacgag gtgaagggtt gattccttct ggatgttgta gtcggcgagg gtgcgcccgt     8880

cctcaagttg ctttccggcg aagatgagac gttgctggtc tggggggatt ccctccttgt     8940

cctggatctt ggccttgacg ttgtcaatgg tgtcagagct ttcgacctct agggttatgg     9000

ttttgccagt gagagtcttg acgaagatct gcatgccacc acggagacga aggacaaggt     9060

gaagggttga ctccttctgg atgttgtagt cggcgagggt acggccgtcc tcgagctgct     9120

ttccggcgaa gatgagacgt tgctgatccg ggggaattcc ttccttgtcc tggatcttgg     9180

ccttgacgtt gtcgatggtg tcagagcttt ccacctcaag ggtgatggtc tttccggtga     9240

gggtcttgac gaagatctgc atctgtagag tcaacaatca caagataaat cagaatcaaa     9300

atccatcacg taatttcaag aagcaatttc gtgaaaaaaa atcctaacct aggctggcag     9360

cacatccccc gttcgcgagc tggcgtaaca gcgaagaggc ccgggcgcgc cactgttaat     9420

aatttttaaa cgtcagcgca ctaaaaaaac gaaaagacgg acacgtgaaa ataaaaaaca     9480

cacactagtt tatgacgcaa tactatttta cttatgattt gggtacatta gacaaaaccg     9540

tgaaagagat gtatcagcta tgaaacctgt atacttcaat acagagactt actcatatcg     9600

gatacgtacg cacgaagtat catattaatt attttaattt ttaataaata ttttatcgga     9660

tacttatgtg atactctaca tatacacaag gatatttcta agatacttta tagatacgta     9720

tcctagaaaa acatgaagag taaaaaagtg agacaatgtt gtaaaaattc attataaatg     9780

tatatgattc aattttagat atgcatcagt ataattgatt ctcgatgaaa cacttaaaat     9840

tatatttctt gtggaagaac gtagcgagag aggtgattca gttagacaac attaaataaa     9900

attaatgtta agttctttta atgatgtttc tctcaatatc acatcatatg aaaatgtaat     9960

atgatttata agaaaatttt taaaaaattt attttaataa tcacatgtac tattttttaa    10020

aaattgtatc ttttataata atacaataat aaagagtaat cagtgttaat ttttcttcaa    10080

atataagttt tattataaat cattgttaac gtatcataag tcattaccgt atcgtatctt    10140

aatttttttt taaaaaccgc taattcacgt acccgtattg tattgtaccc gcacctgtat    10200

cacaatcgat cttagttaga agaattgtct cgaggcggtg caagacagca tataatagac    10260

gtggactctc ttataccaaa cgttgtcgta tcacaaaggg ttaggtaaca agtcacagtt    10320

tgtccacgtg tcacgtttta attggaagag gtgccgttgg cgtaatataa cagccaatcg    10380

atttttgcta taaaagcaaa tcaggtaaac taaacttctt cattcttttc ttccccatcg    10440

ctacaaaacc ggttcctttg gaaaagagat tcattcaaac ctagcaccca attccgtttc    10500

aaggtataat ctactttcta ttcttcgatt attttattat tattagctac tatcgtttaa    10560

tcgatctttt cttttgatcc gtcaaattta aattcaatta gggttttgtt cttttctttc    10620

atctgattga aatccttctg aattgaaccg tttacttgat tttactgttt attgtatgat    10680

ttaatccttt gtttttcaaa gacagtcttt agattgtgat taggggttca tataaatttt    10740

tagatttgga tttttgtatt gtatgattca aaaaatacgt cctttaatta gattagtaca    10800

tggatatttt ttacccgatt tattgattgt cagggagaat ttgatgagca agtttttttg    10860

atgtctgttg taaattgaat tgattataat tgctgatctg ctgcttccag ttttcataac    10920

ccatattctt ttaaccttgt tgtacacaca atgaaaaatt ggtgattgat tcatttgttt    10980

ttctttgttt tggattatac agggtatggc gccgccgcct gccctccctc caaagaggcg    11040

aagaagtggt ggatcttccg gggggtcccc ccctcctgct ttacctccaa aaagacgtcg    11100

ttctggtggt tcaagtggag gttctccacc tcctgcactt cctcccaaga gaagaaggag    11160

cggcggcagc tcaggaggat caccaccacc agctttgcca cccaaaaggc gccggggctc    11220

ctccgagaca ccaggcacct ccgagagcgc gacgcccgag ggcggctccg gcggctccgg    11280

cagctccaag ctggagaagt ttacaaactg ttacagcctc tccaaaaccc tcaggtttaa    11340

agcgatcccg gtgggcaaga cccaggagaa catcgacaac aagaggctcc tggtggaaga    11400

cgagaagcgc gccgaagact acaagggcgt gaagaagctg ctcgataggt actacctcag    11460

ctttattaac gacgtgctgc acagcatcaa actcaagaat ctcaacaact acatctccct    11520

cttccgcaaa aagacccgca ccgagaagga gaacaaggag ctggagaacc tggagatcaa    11580

cctccgcaag gaaatcgcca aagcgttcaa gggcaatgaa gggtacaaga gcctcttcaa    11640

gaaagacatc atcgaaacta tcctcccaga gtttctcgat gacaaggacg agatcgcgct    11700

ggtgaactcc tttaacgggt tcacaaccgc gtttaccggc ttctttgata acagggaaaa    11760

tatgttctcc gaggaggcca agtccaccag catcgccttc aggtgtatca acgagaacct    11820

cacccgctac atttccaata tggacatttt cgagaaggtg gatgcgatct tcgataagca    11880

cgaggtgcag gagatcaaag agaagattct caattccgat tatgacgtcg aggatttctt    11940

cgaaggggag ttctttaatt ttgtgctcac acaagagggc attgacgtgt acaacgcgat    12000

tatcgggggc ttcgtcacag agtccgggga gaagattaag gggctgaatg agtacatcaa    12060

tctgtacaat cagaagacca agcagaaact gccgaaattc aagccgctct acaagcaagt    12120

cctgtccgat agggaaagcc tctccttcta cggcgagggc tataccagcg acgaggaggt    12180

gctggaagtc ttccgcaaca cactgaataa gaatagcgag attttctcct ccatcaagaa    12240

gctcgagaag ctctttaaga actttgacga gtacagctcc gccgggattt tcgtgaagaa    12300

cgggccggcg atcagcacca tctccaagga catctttggc gagtggaacg tcatcaggga    12360

caagtggaac gccgagtacg acgacatcca cctgaagaag aaggcggtgg tgaccgagaa    12420

gtatgaggac gatcgcagga agtccttcaa aaaaatcggc tccttcagcc tcgaacagct    12480

ccaggagtat gccgatgcgg atctgtccgt cgtcgagaag ctgaaggaaa tcatcattca    12540

gaaggtcgac gagatctata aagtgtacgg gtccagcgag aagctgttcg acgccgactt    12600

tgtgctcgag aagtccctca aaaagaatga cgccgtggtg gccattatga aagacctgct    12660

cgactccgtg aagtccttcg aaaattacat taaagcgttc tttggggagg ggaaggaaac    12720

taacagggat gagtccttct atggcgactt tgtcctcgcg tacgacatcc tgctgaaggt    12780

cgaccacatt tacgacgcga tccgcaacta cgtgacacag aagccgtact ccaaagacaa    12840

gttcaagctg tacttccaga acccgcaatt tatggggggc tgggacaagg ataaagagac    12900

agactaccgc gcgacaattc tccgctatgg ctccaaatac tatctggcca tcatggacaa    12960

gaagtacgcg aagtgcctgc agaagatcga caaagacgac gtcaatggca actatgaaaa    13020

gatcaactac aagctgctgc cgggtccgaa caagatgctc ccgaaggtgt tcttcagcaa    13080

gaagtggatg gcctactaca atccaagcga ggatattcag aaaatctata aaaacgggac    13140

cttcaagaag ggggacatgt ttaacctcaa cgactgccac aagctcattg atttcttcaa    13200

ggatagcatt tcccgctacc cgaaatggtc caatgcgtac gattttaact tctccgagac    13260

agaaaagtac aaagacatcg cgggctttta cagggaggtg gaggagcaag ggtataaagt    13320

ttcttttgaa tccgcgagca agaaggaagt cgacaagctc gtcgaggagg gcaagctcta    13380

catgttccaa atttataaca aggacttttc cgacaagagc catgggaccc caaacctcca    13440

caccatgtac ttcaaactgc tctttgacga gaacaaccac gggcaaatca ggctgagcgg    13500

cggcgccgaa ttattcatgc gcagggcctc cctcaagaag gaagagctgg tcgtccatcc    13560

agccaattcc ccgatcgcga acaagaaccc ggacaatccg aaaaagacca ccaccctgtc    13620

ctacgacgtc tacaaggaca aacgcttcag cgaagaccag tacgaattac acatcccaat    13680

tgcgattaat aagtgcccaa agaatatctt caaaattaat acagaggtca gggtgctgct    13740

caaacacgac gacaatccgt atgtcatcgg cattgacagg ggcgagcgca atctgctcta    13800

tatcgtggtc gtggatggga agggcaatat tgtggagcag tactccctga acgagattat    13860

caacaacttc aatgggatta ggattaagac cgactatcac agcctgctcg acaagaaaga    13920

aaaagagagg tttgaggccc gccaaaactg gacctccatt gagaatatca aagaattaaa    13980

ggccggctat atttcccaag tcgtccacaa gatctgcgag ctggtggaga aatatgacgc    14040

cgtgattgcg ctcgaagact taaattctgg gttcaagaac tcccgcgtga aggtggaaaa    14100

acaggtgtat cagaaattcg agaaaatgct gatcgacaaa ctcaattata tggtggataa    14160

gaagtccaac ccgtgtgcca cagggggcgc gctgaagggc tatcagatca ccaacaagtt    14220

cgagagcttc aagagcatga gcacccagaa cgggtttatt ttctacatcc cggcgtggct    14280

cacctccaag attgacccga gcaccggctt cgtgaacctc ctgaagacaa agtatacctc    14340

cattgccgac agcaagaagt ttatctcctc cttcgaccgc attatgtatg tgccggagga    14400

ggacctcttc gagttcgccc tcgactacaa aaacttcagc cgcacagatg cggattacat    14460

caagaagtgg aagctgtact cctacgggaa caggatccgc atcttcagga atccaaaaaa    14520

aaataacgtc tttgactggg aggaagtgtg cctgacatcc gcctacaagg aactgttcaa    14580

taaatacggc atcaattacc agcagggcga cattcgcgcc ctcctctgtg agcagtccga    14640

caaagcgttt tactccagct tcatggccct catgtccctg atgctccaaa tgaggaatag    14700

catcacaggg cgcaccgacg tcgacttcct catcagcccg gtgaagaact ccgacgggat    14760

cttttacgac tcccgcaact atgaggcgca agagaatgcg atcctcccga agaacgccga    14820

tgcgaacggg gcctataata tcgccaggaa agtgctctgg gccatcgggc agttcaaaaa    14880

ggcggaggat gagaagctcg acaaggtgaa aattgccatt tccaacaagg agtggctgga    14940

gtacgcgcag acctccgtga agcactgaaa gggctctctg tcatgatttc atactttcat    15000

tattgagctc tgtaattaca attatgacca tgagaacatc tcttattgtg tggcctttta    15060

attgctgatg ttagtactga accaaagctt atcgtgatga tgtaaaagca ataagtactt    15120

gtttgtagct tctttgtgtc tccctttggg cttaatacat ctgtttagtg ttgtggcttt    15180

ggcatagact tctcttggta ataatgcctt gcaatgcaaa atttcaatta tcaaattcta    15240

ttatgttctc accttatggt aacagcttac cctgtggaag atgagattct tgagttgagt    15300

cattgccaat ttttggcatt agcttttgaa ttagtgaatt ttgacaaaaa ttaccgtgac    15360

actgattttg ttgaagctct taagtgtagt ttttacaaaa tttcagtggc tcgttgtgat    15420

tatgtcaaac tcacggcgaa tgtagttctt acagaatttc agtggctccc tgcaggctcg    15480

aggtcattca tatgcttgag aagagagtcg ggatagtcca aaataaaaca aaggtaagat    15540

tacctggtca aaagtgaaaa catcagttaa aaggtggtat aaagtaaaat atcggtaata    15600

aaaggtggcc caaagtgaaa tttactcttt tctactatta taaaaattga ggatgttttt    15660

gtcggtactt tgatacgtca tttttgtatg aattggtttt taagtttatt cgcttttgga    15720

aatgcatatc tgtatttgag tcgggtttta agttcgtttg cttttgtaaa tacagaggga    15780

tttgtataag aaatatcttt agaaaaaccc atatgctaat ttgacataat ttttgagaaa    15840

aatatatatt caggcgaatt ctcacaatga acaataataa gattaaaata gctttccccc    15900

gttgcagcgc atgggtattt tttctagtaa aaataaaaga taaacttaga ctcaaaacat    15960

ttacaaaaac aacccctaaa gttcctaaag cccaaagtgc tatccacgat ccatagcaag    16020

cccagcccaa cccaacccaa cccaacccac cccagtccag ccaactggac aatagtctcc    16080

acaccccccc actatcaccg tgagttgtcc gcacgcaccg cacgtctcgc agccaaaaaa    16140

aaaaagaaag aaaaaaaaga aaaagaaaaa acagcaggtg ggtccgggtc gtgggggccg    16200

gaaacgcgag gaggatcgcg agccagcgac gaggagctta ggcctcatcg ttgaagatgc    16260

ctctgccgac agtggtccca aagatggacc cccacccacg aggagcatcg tggaaaaaga    16320

agacgttcca accacgtctt caaagcaagt ggattgatgt gatatctcca ctgacgtaag    16380

ggatgacgca caatcccact atccttcgag gcctcatcgt tgaagatgcc tctgccgaca    16440

gtggtcccaa agatggaccc ccacccacga ggagcatcgt ggaaaaagaa gacgttccaa    16500

ccacgtcttc aaagcaagtg gattgatgtg atatctccac tgacgtaagg gatgacgcac    16560

aatcccacta tccttcgaag ctccctccct ccgcttccaa agaaacgccc cccatcgcca    16620

ctatatacat acccccccct ctcctcccat ccccccaacc cttctagaac catcttccac    16680

acactcaagc cacactattg gagaacacac agggacaaca caccataaga tccaagggag    16740

gcctccgccg ccgccggtaa ccaccccgcc cctctcctct ttctttctcc gttttttttt    16800

ccgtctcggt ctcgatcttt ggccttggta gtttgggtgg gcgagaggcg gcttcgtgcg    16860

cgcccagatc ggtgcgcggg aggggcggga tctcgcggct ggggctctcg ccggcgtgga    16920

tccggcccgg atctcgcggg gaatggggct ctcggatgta gatctgcgat ccgccgttgt    16980

tgggggagat gatggggggt ttaaaatttc cgccgtgcta aacaagatca ggaagagggg    17040

aaaagggcac tatggtttat atttttatat atttctgctg cttcgtcagg cttagatgtg    17100

ctagatcttt ctttcttctt tttgtgggta gaatttgaat ccctcagcat tgttcatcgg    17160

tagtttttct tttcatgatt tgtgacaaat gcagcctcgt gcggagcttt tttgtaggta    17220

gaaggcggcc gcatggccca gtctaagcac gggttgacga aggagatgac tatgaagtat    17280

cgcatggaag gctgcgttga cggccacaaa ttcgtcatta ccggcgaggg catcggctac    17340

ccctttaagg taagtttctg cttctacctt tgatatatat ataataatta tcattaatta    17400

gtagtaatat aatatttcaa atattttttt caaaataaaa gaatgtagta tatagcaatt    17460

gcttttctgt agtttataag tgtgtatatt ttaatttata acttttctaa tatatgacca    17520

aaatttgttg atgtgcaggg caagcaagcg ataaacctgt gcgtggtgga gggtggccct    17580

ctgcccttcg ccgaggatat actctcagcc gccttcatgt acgggaatcg ggtgttcacg    17640

gagtacccgc aagacatcgt ggactacttc aagaactcct gccccgccgg atacacatgg    17700

gaccgttcct tcctcttcga ggacggagcc gtttgcatct gcaacgcgga catcaccgtg    17760

tccgtcgagg agaactgcat gtaccacgag tcaaagttct atggagtgaa cttcccggcc    17820

gatggtcccg tgatgaagaa aatgacggac aactgggagc cgtcgtgcga gaaaatcatt    17880

cccgtcccaa aacagggaat cctcaagggc gacgtgtcga tgtacctact tctcaaggac    17940

ggtggacggc tacggtgcca gttcgacact gtttacaagg cgaagtcggt gccgaggaag    18000

atgccggact ggcactttat ccagcacaag ctgacaaggg aggacagaag cgacgctaag    18060

aaccagaaat ggcacctcac cgagcacgcc atcgccagtg gctctgcgct gcccgggtga    18120

ccctgcaatg tgaccctaga cttgtccatc ttctggattg gccaacttaa ttaatgtatg    18180

aaataaaagg atgcacacat agtgacatgc taatcactat aatgtgggca tcaaagttgt    18240

gtgttatgtg taattactaa ttatctgaat aagagaaaga gatcatccat atttcttatc    18300

ctaaatgaat gtcacgtgtc tttataattc tttgatgaac cagatgcatt ttattaacca    18360

attccatata catataaata ttaatcatat ataattaata tcaattgggt tagcaaaaca    18420

aatctagtct aggtgtgttt tgctaattat tgggggatag tgcaaaaaga aatctacgtt    18480

ctcaataatt cagatagaaa acttaataaa gtgagataat ttacatagat tgcttttatc    18540

ctttgatata tgtgaaacca tgcatgatat aaggaaaata gatagagaaa taatttttta    18600

catcgttgaa tatgtaaaca atttaattca agaagctagg aatataaata ttgaggagtt    18660

tatgattatt attattattt tgatgttcaa tgaagttttt tttaatttca tatgaagtat    18720

acaaaaattc ttcatagatt tttgtttcta tgccgtagtt atctttaata tatttgtggt    18780

tgaagaaatt tattgctaga aacgaatgga ttgtcaattt ttttttaaag caaatatata    18840

tgaaattata ctgtatatta ttttagtcat gattaaaatg tggccttaat tgaatcatct    18900

ttctcattca ttttttcaaa agcatatcag gatgattgat atttatctat tttaaaaatt    18960

aatttaaggg ttcaaattaa atttaactta aaagtgtcct aaccgtagtt aaaggtttac    19020

tttaaaaaaa tactatgaaa aatctaatct tctatgaatc gagggccctt agctagttag    19080


<210>  95
<211>  18812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3788 Full plasmid sequence

<400>  95
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctaaaaga ttgacacatt gcctatacta cattctagcg taggttaaat     8160

ttatatcaga taatgtggga gaaagagatc agttaccatt gcatgacaat agctgacccc     8220

agatatgagt tgttgaaaga agaaacgagc ctgtggcatg acaatgggtt aatagttaca     8280

caggaaatag agagctagca caagcaaaag taaacaaatt gtataagaac ctcatcctca     8340

ttaaaacgcc ctgcattgca gattttctca aatagttctc caccagatgc atattccatt     8400

acaatgtcta gatgagtcgg tgttagaata acctgagtca aatatcaaag aacattttcc     8460

atgaatatga ttattgtacc tctgaacata aaaatatata aatacaaata tataccaacc     8520

tccttaaacc tgataatgtt aggatgtctt agagacctgt gattaatgat ttctctttta     8580

acattttcat caatctgtga cacacagcaa atgatagggg gcgcgccact gttaataatt     8640

tttaaacgtc agcgcactaa aaaaacgaaa agacggacac gtgaaaataa aaaacacaca     8700

ctagtttatg acgcaatact attttactta tgatttgggt acattagaca aaaccgtgaa     8760

agagatgtat cagctatgaa acctgtatac ttcaatacag agacttactc atatcggata     8820

cgtacgcacg aagtatcata ttaattattt taatttttaa taaatatttt atcggatact     8880

tatgtgatac tctacatata cacaaggata tttctaagat actttataga tacgtatcct     8940

agaaaaacat gaagagtaaa aaagtgagac aatgttgtaa aaattcatta taaatgtata     9000

tgattcaatt ttagatatgc atcagtataa ttgattctcg atgaaacact taaaattata     9060

tttcttgtgg aagaacgtag cgagagaggt gattcagtta gacaacatta aataaaatta     9120

atgttaagtt cttttaatga tgtttctctc aatatcacat catatgaaaa tgtaatatga     9180

tttataagaa aatttttaaa aaatttattt taataatcac atgtactatt ttttaaaaat     9240

tgtatctttt ataataatac aataataaag agtaatcagt gttaattttt cttcaaatat     9300

aagttttatt ataaatcatt gttaacgtat cataagtcat taccgtatcg tatcttaatt     9360

tttttttaaa aaccgctaat tcacgtaccc gtattgtatt gtacccgcac ctgtatcaca     9420

atcgatctta gttagaagaa ttgtctcgag gcggtgcaag acagcatata atagacgtgg     9480

actctcttat accaaacgtt gtcgtatcac aaagggttag gtaacaagtc acagtttgtc     9540

cacgtgtcac gttttaattg gaagaggtgc cgttggcgta atataacagc caatcgattt     9600

ttgctataaa agcaaatcag gtaaactaaa cttcttcatt cttttcttcc ccatcgctac     9660

aaaaccggtt cctttggaaa agagattcat tcaaacctag cacccaattc cgtttcaagg     9720

tataatctac tttctattct tcgattattt tattattatt agctactatc gtttaatcga     9780

tcttttcttt tgatccgtca aatttaaatt caattagggt tttgttcttt tctttcatct     9840

gattgaaatc cttctgaatt gaaccgttta cttgatttta ctgtttattg tatgatttaa     9900

tcctttgttt ttcaaagaca gtctttagat tgtgattagg ggttcatata aatttttaga     9960

tttggatttt tgtattgtat gattcaaaaa atacgtcctt taattagatt agtacatgga    10020

tattttttac ccgatttatt gattgtcagg gagaatttga tgagcaagtt tttttgatgt    10080

ctgttgtaaa ttgaattgat tataattgct gatctgctgc ttccagtttt cataacccat    10140

attcttttaa ccttgttgta cacacaatga aaaattggtg attgattcat ttgtttttct    10200

ttgttttgga ttatacaggg tatggcgccg ccgcctgccc tccctccaaa gaggcgaaga    10260

agtggtggat cttccggggg gtccccccct cctgctttac ctccaaaaag acgtcgttct    10320

ggtggttcaa gtggaggttc tccacctcct gcacttcctc ccaagagaag aaggagcggc    10380

ggcagctcag gaggatcacc accaccagct ttgccaccca aaaggcgccg gggctcctcc    10440

gagacaccag gcacctccga gagcgcgacg cccgagggcg gctccggcgg ctccggcagc    10500

tccaagctgg agaagtttac aaactgttac agcctctcca aaaccctcag gtttaaagcg    10560

atcccggtgg gcaagaccca ggagaacatc gacaacaaga ggctcctggt ggaagacgag    10620

aagcgcgccg aagactacaa gggcgtgaag aagctgctcg ataggtacta cctcagcttt    10680

attaacgacg tgctgcacag catcaaactc aagaatctca acaactacat ctccctcttc    10740

cgcaaaaaga cccgcaccga gaaggagaac aaggagctgg agaacctgga gatcaacctc    10800

cgcaaggaaa tcgccaaagc gttcaagggc aatgaagggt acaagagcct cttcaagaaa    10860

gacatcatcg aaactatcct cccagagttt ctcgatgaca aggacgagat cgcgctggtg    10920

aactccttta acgggttcac aaccgcgttt accggcttct ttgataacag ggaaaatatg    10980

ttctccgagg aggccaagtc caccagcatc gccttcaggt gtatcaacga gaacctcacc    11040

cgctacattt ccaatatgga cattttcgag aaggtggatg cgatcttcga taagcacgag    11100

gtgcaggaga tcaaagagaa gattctcaat tccgattatg acgtcgagga tttcttcgaa    11160

ggggagttct ttaattttgt gctcacacaa gagggcattg acgtgtacaa cgcgattatc    11220

gggggcttcg tcacagagtc cggggagaag attaaggggc tgaatgagta catcaatctg    11280

tacaatcaga agaccaagca gaaactgccg aaattcaagc cgctctacaa gcaagtcctg    11340

tccgataggg aaagcctctc cttctacggc gagggctata ccagcgacga ggaggtgctg    11400

gaagtcttcc gcaacacact gaataagaat agcgagattt tctcctccat caagaagctc    11460

gagaagctct ttaagaactt tgacgagtac agctccgccg ggattttcgt gaagaacggg    11520

ccggcgatca gcaccatctc caaggacatc tttggcgagt ggaacgtcat cagggacaag    11580

tggaacgccg agtacgacga catccacctg aagaagaagg cggtggtgac cgagaagtat    11640

gaggacgatc gcaggaagtc cttcaaaaaa atcggctcct tcagcctcga acagctccag    11700

gagtatgccg atgcggatct gtccgtcgtc gagaagctga aggaaatcat cattcagaag    11760

gtcgacgaga tctataaagt gtacgggtcc agcgagaagc tgttcgacgc cgactttgtg    11820

ctcgagaagt ccctcaaaaa gaatgacgcc gtggtggcca ttatgaaaga cctgctcgac    11880

tccgtgaagt ccttcgaaaa ttacattaaa gcgttctttg gggaggggaa ggaaactaac    11940

agggatgagt ccttctatgg cgactttgtc ctcgcgtacg acatcctgct gaaggtcgac    12000

cacatttacg acgcgatccg caactacgtg acacagaagc cgtactccaa agacaagttc    12060

aagctgtact tccagaaccc gcaatttatg gggggctggg acaaggataa agagacagac    12120

taccgcgcga caattctccg ctatggctcc aaatactatc tggccatcat ggacaagaag    12180

tacgcgaagt gcctgcagaa gatcgacaaa gacgacgtca atggcaacta tgaaaagatc    12240

aactacaagc tgctgccggg tccgaacaag atgctcccga aggtgttctt cagcaagaag    12300

tggatggcct actacaatcc aagcgaggat attcagaaaa tctataaaaa cgggaccttc    12360

aagaaggggg acatgtttaa cctcaacgac tgccacaagc tcattgattt cttcaaggat    12420

agcatttccc gctacccgaa atggtccaat gcgtacgatt ttaacttctc cgagacagaa    12480

aagtacaaag acatcgcggg cttttacagg gaggtggagg agcaagggta taaagtttct    12540

tttgaatccg cgagcaagaa ggaagtcgac aagctcgtcg aggagggcaa gctctacatg    12600

ttccaaattt ataacaagga cttttccgac aagagccatg ggaccccaaa cctccacacc    12660

atgtacttca aactgctctt tgacgagaac aaccacgggc aaatcaggct gagcggcggc    12720

gccgaattat tcatgcgcag ggcctccctc aagaaggaag agctggtcgt ccatccagcc    12780

aattccccga tcgcgaacaa gaacccggac aatccgaaaa agaccaccac cctgtcctac    12840

gacgtctaca aggacaaacg cttcagcgaa gaccagtacg aattacacat cccaattgcg    12900

attaataagt gcccaaagaa tatcttcaaa attaatacag aggtcagggt gctgctcaaa    12960

cacgacgaca atccgtatgt catcggcatt gacaggggcg agcgcaatct gctctatatc    13020

gtggtcgtgg atgggaaggg caatattgtg gagcagtact ccctgaacga gattatcaac    13080

aacttcaatg ggattaggat taagaccgac tatcacagcc tgctcgacaa gaaagaaaaa    13140

gagaggtttg aggcccgcca aaactggacc tccattgaga atatcaaaga attaaaggcc    13200

ggctatattt cccaagtcgt ccacaagatc tgcgagctgg tggagaaata tgacgccgtg    13260

attgcgctcg aagacttaaa ttctgggttc aagaactccc gcgtgaaggt ggaaaaacag    13320

gtgtatcaga aattcgagaa aatgctgatc gacaaactca attatatggt ggataagaag    13380

tccaacccgt gtgccacagg gggcgcgctg aagggctatc agatcaccaa caagttcgag    13440

agcttcaaga gcatgagcac ccagaacggg tttattttct acatcccggc gtggctcacc    13500

tccaagattg acccgagcac cggcttcgtg aacctcctga agacaaagta tacctccatt    13560

gccgacagca agaagtttat ctcctccttc gaccgcatta tgtatgtgcc ggaggaggac    13620

ctcttcgagt tcgccctcga ctacaaaaac ttcagccgca cagatgcgga ttacatcaag    13680

aagtggaagc tgtactccta cgggaacagg atccgcatct tcaggaatcc aaaaaaaaat    13740

aacgtctttg actgggagga agtgtgcctg acatccgcct acaaggaact gttcaataaa    13800

tacggcatca attaccagca gggcgacatt cgcgccctcc tctgtgagca gtccgacaaa    13860

gcgttttact ccagcttcat ggccctcatg tccctgatgc tccaaatgag gaatagcatc    13920

acagggcgca ccgacgtcga cttcctcatc agcccggtga agaactccga cgggatcttt    13980

tacgactccc gcaactatga ggcgcaagag aatgcgatcc tcccgaagaa cgccgatgcg    14040

aacggggcct ataatatcgc caggaaagtg ctctgggcca tcgggcagtt caaaaaggcg    14100

gaggatgaga agctcgacaa ggtgaaaatt gccatttcca acaaggagtg gctggagtac    14160

gcgcagacct ccgtgaagca ctgaaagggc tctctgtcat gatttcatac tttcattatt    14220

gagctctgta attacaatta tgaccatgag aacatctctt attgtgtggc cttttaattg    14280

ctgatgttag tactgaacca aagcttatcg tgatgatgta aaagcaataa gtacttgttt    14340

gtagcttctt tgtgtctccc tttgggctta atacatctgt ttagtgttgt ggctttggca    14400

tagacttctc ttggtaataa tgccttgcaa tgcaaaattt caattatcaa attctattat    14460

gttctcacct tatggtaaca gcttaccctg tggaagatga gattcttgag ttgagtcatt    14520

gccaattttt ggcattagct tttgaattag tgaattttga caaaaattac cgtgacactg    14580

attttgttga agctcttaag tgtagttttt acaaaatttc agtggctcgt tgtgattatg    14640

tcaaactcac ggcgaatgta gttcttacag aatttcagtg gctccctgca ggctcgaggt    14700

cattcatatg cttgagaaga gagtcgggat agtccaaaat aaaacaaagg taagattacc    14760

tggtcaaaag tgaaaacatc agttaaaagg tggtataaag taaaatatcg gtaataaaag    14820

gtggcccaaa gtgaaattta ctcttttcta ctattataaa aattgaggat gtttttgtcg    14880

gtactttgat acgtcatttt tgtatgaatt ggtttttaag tttattcgct tttggaaatg    14940

catatctgta tttgagtcgg gttttaagtt cgtttgcttt tgtaaataca gagggatttg    15000

tataagaaat atctttagaa aaacccatat gctaatttga cataattttt gagaaaaata    15060

tatattcagg cgaattctca caatgaacaa taataagatt aaaatagctt tcccccgttg    15120

cagcgcatgg gtattttttc tagtaaaaat aaaagataaa cttagactca aaacatttac    15180

aaaaacaacc cctaaagttc ctaaagccca aagtgctatc cacgatccat agcaagccca    15240

gcccaaccca acccaaccca acccacccca gtccagccaa ctggacaata gtctccacac    15300

ccccccacta tcaccgtgag ttgtccgcac gcaccgcacg tctcgcagcc aaaaaaaaaa    15360

agaaagaaaa aaaagaaaaa gaaaaaacag caggtgggtc cgggtcgtgg gggccggaaa    15420

cgcgaggagg atcgcgagcc agcgacgagg agcttaggcc tcatcgttga agatgcctct    15480

gccgacagtg gtcccaaaga tggaccccca cccacgagga gcatcgtgga aaaagaagac    15540

gttccaacca cgtcttcaaa gcaagtggat tgatgtgata tctccactga cgtaagggat    15600

gacgcacaat cccactatcc ttcgaggcct catcgttgaa gatgcctctg ccgacagtgg    15660

tcccaaagat ggacccccac ccacgaggag catcgtggaa aaagaagacg ttccaaccac    15720

gtcttcaaag caagtggatt gatgtgatat ctccactgac gtaagggatg acgcacaatc    15780

ccactatcct tcgaagctcc ctccctccgc ttccaaagaa acgcccccca tcgccactat    15840

atacataccc ccccctctcc tcccatcccc ccaacccttc tagaaccatc ttccacacac    15900

tcaagccaca ctattggaga acacacaggg acaacacacc ataagatcca agggaggcct    15960

ccgccgccgc cggtaaccac cccgcccctc tcctctttct ttctccgttt ttttttccgt    16020

ctcggtctcg atctttggcc ttggtagttt gggtgggcga gaggcggctt cgtgcgcgcc    16080

cagatcggtg cgcgggaggg gcgggatctc gcggctgggg ctctcgccgg cgtggatccg    16140

gcccggatct cgcggggaat ggggctctcg gatgtagatc tgcgatccgc cgttgttggg    16200

ggagatgatg gggggtttaa aatttccgcc gtgctaaaca agatcaggaa gaggggaaaa    16260

gggcactatg gtttatattt ttatatattt ctgctgcttc gtcaggctta gatgtgctag    16320

atctttcttt cttctttttg tgggtagaat ttgaatccct cagcattgtt catcggtagt    16380

ttttcttttc atgatttgtg acaaatgcag cctcgtgcgg agcttttttg taggtagaag    16440

gcggccgcat ggcccagtct aagcacgggt tgacgaagga gatgactatg aagtatcgca    16500

tggaaggctg cgttgacggc cacaaattcg tcattaccgg cgagggcatc ggctacccct    16560

ttaaggtaag tttctgcttc tacctttgat atatatataa taattatcat taattagtag    16620

taatataata tttcaaatat ttttttcaaa ataaaagaat gtagtatata gcaattgctt    16680

ttctgtagtt tataagtgtg tatattttaa tttataactt ttctaatata tgaccaaaat    16740

ttgttgatgt gcagggcaag caagcgataa acctgtgcgt ggtggagggt ggccctctgc    16800

ccttcgccga ggatatactc tcagccgcct tcatgtacgg gaatcgggtg ttcacggagt    16860

acccgcaaga catcgtggac tacttcaaga actcctgccc cgccggatac acatgggacc    16920

gttccttcct cttcgaggac ggagccgttt gcatctgcaa cgcggacatc accgtgtccg    16980

tcgaggagaa ctgcatgtac cacgagtcaa agttctatgg agtgaacttc ccggccgatg    17040

gtcccgtgat gaagaaaatg acggacaact gggagccgtc gtgcgagaaa atcattcccg    17100

tcccaaaaca gggaatcctc aagggcgacg tgtcgatgta cctacttctc aaggacggtg    17160

gacggctacg gtgccagttc gacactgttt acaaggcgaa gtcggtgccg aggaagatgc    17220

cggactggca ctttatccag cacaagctga caagggagga cagaagcgac gctaagaacc    17280

agaaatggca cctcaccgag cacgccatcg ccagtggctc tgcgctgccc gggtgaccct    17340

gcaatgtgac cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat    17400

aaaaggatgc acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt    17460

tatgtgtaat tactaattat ctgaataaga gaaagagatc atccatattt cttatcctaa    17520

atgaatgtca cgtgtcttta taattctttg atgaaccaga tgcattttat taaccaattc    17580

catatacata taaatattaa tcatatataa ttaatatcaa ttgggttagc aaaacaaatc    17640

tagtctaggt gtgttttgct aattattggg ggatagtgca aaaagaaatc tacgttctca    17700

ataattcaga tagaaaactt aataaagtga gataatttac atagattgct tttatccttt    17760

gatatatgtg aaaccatgca tgatataagg aaaatagata gagaaataat tttttacatc    17820

gttgaatatg taaacaattt aattcaagaa gctaggaata taaatattga ggagtttatg    17880

attattatta ttattttgat gttcaatgaa gtttttttta atttcatatg aagtatacaa    17940

aaattcttca tagatttttg tttctatgcc gtagttatct ttaatatatt tgtggttgaa    18000

gaaatttatt gctagaaacg aatggattgt caattttttt ttaaagcaaa tatatatgaa    18060

attatactgt atattatttt agtcatgatt aaaatgtggc cttaattgaa tcatctttct    18120

cattcatttt ttcaaaagca tatcaggatg attgatattt atctatttta aaaattaatt    18180

taagggttca aattaaattt aacttaaaag tgtcctaacc gtagttaaag gtttacttta    18240

aaaaaatact atgaaaaatc taatcttcta tgaatcgagg gcccttagct agttagacga    18300

taaaaatgtt ttaaacgata tatattataa aaaaaaacgt ttcaaaaata aatacaaaaa    18360

tgtttttaaa tatatataat ttaactcatt aaagaaaata aaaatgcaag tgcggtgaca    18420

agacaagcta aaagttgcaa aagaaatggc agggctataa ggctcaccta ctcctggatt    18480

taccaaattt tggttcgtcc ctatactcga aaaataaaac aaaataaatt tcagtatctt    18540

cgtttttgta tgctttgact gtgaggcgag gccaactttc ttcttctgtc tgagatgaat    18600

tttgtttgcc tcctgtgaag gatgtatcat tcaaagtgaa tgttttgcaa ctgccagtag    18660

tcccacatcg accaaatatt cttattacag tgtgtttata tagcacctgg agaaggaatg    18720

ggttgtttca aagattaaat aatttctact aagtgtagat acacctactc atctggccat    18780

tgttaatttc tactaagtgt agattttttt ta                                  18812


<210>  96
<211>  19080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3771 Full plasmid sequence

<400>  96
aagcttcgat aaaaatgttt taaacgatat atattataaa aaaaaacgtt tcaaaaataa       60

atacaaaaat gtttttaaat atatataatt taactcatta aagaaaataa aaatgcaagt      120

gcggtgacaa gacaagctaa aagttgcaaa agaaatggca gggctataag gctcacctac      180

tcctggattt accaaatttt ggttcgtccc tatactcgaa aaataaaaca aaataaattt      240

cagtatcttc gtttttgtat gctttgactg tgaggcgagg ccaactttct tcttctgtct      300

gagatgaatt ttgtttgcct cctgtgaagg atgtatcatt caaagtgaat gttttgcaac      360

tgccagtagt cccacatcga ccaaatattc ttattacagt gtgtttatat agcacctgga      420

gaaggaatgg gttgtttcaa agattaaata atttctacta agtgtagatt gtgtgatgtt      480

cgatgttgga tttaatttct actaagtgta gatttttttt actagtgata tccgtcgact      540

ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt ggacgtgaat      600

gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc tttcgcctat      660

aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt ataataacgc      720

tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc tttttctcca      780

tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa gccatttaca      840

attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca tgttggtttc      900

tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc atgtgcacct      960

tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact tttcctagct     1020

tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc tggggggatg     1080

ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc cttcggcgtg     1140

cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa tattggttta     1200

aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc cttgcaaatg     1260

ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc tcatctgtca     1320

gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt cgcgcccctc     1380

aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg tgggaaactc     1440

gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt cgccggccga     1500

aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc tcaagtgtca     1560

acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc acaacgccgg     1620

cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt ttgcagggcc     1680

atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg gaaagggtcg     1740

atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg gcgcggggca     1800

tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta ggacaggtgc     1860

cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg acgatgatcg     1920

gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc gtcactggtc     1980

ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg gccgacgcgc     2040

tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc attatgattc     2100

ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc aggcaggtag     2160

atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc ctaacttcga     2220

tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca tggaacgggt     2280

tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg cgtcgcggtg     2340

catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta acggattcac     2400

cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc aaaccaaccc     2460

ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc gcatctcggg     2520

cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga ggacccggct     2580

aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg agcgaacgtg     2640

aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg tcttcggttt     2700

ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta tgttccggat     2760

ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat taacgaagcg     2820

ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg ccagttgttt     2880

accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta tcgtgagcat     2940

cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt acacggaggc     3000

atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca gaagccagac     3060

attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag acatctgtga     3120

atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt tcggtgatga     3180

cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga     3240

tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggcgc     3300

agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta tgcggcatca     3360

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     3420

agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc     3480

gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt atccacagaa     3540

tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3600

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3660

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     3720

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     3780

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     3840

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     3900

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     3960

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4020

acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt atttggtatc     4080

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4140

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4200

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4260

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     4320

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     4380

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     4440

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     4500

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     4560

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     4620

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     4680

aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa ttcattcaag     4740

ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagt attcaacatt     4800

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4860

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4920

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4980

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     5040

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     5100

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     5160

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     5220

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     5280

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     5340

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     5400

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5460

gctggtttat tgctgataaa tctggagccg gtgagcgtgg ttctcgcggt atcattgcag     5520

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5580

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5640

ggtaatgtct aacaattcgt tcaagccgac gccgcttcgc ggcgcggctt aactcaagcg     5700

ttagatgctg caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     5760

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     5820

tccttcggtc ctccgatcga ggatttttcg gcgctgcgct acgtccgcga ccgcgttgag     5880

ggatcaagcc acagcagccc actcgacctt ctagccgacc cagacgagcc aagggatctt     5940

tttggaatgc tgctccgtcg tcaggctttc cgacgtttgg gtggttgaac agaagtcatt     6000

atcgcacgga atgccaagca ctcccgaggg gaaccctgtg gttggcatgc acatacaaat     6060

ggacgaacgg ataaaccttt tcacgccctt ttaaatatcc gattattcta ataaacgctc     6120

ttttctctta ggtttacccg ccaatatatc ctgtcaaaca ctgatagttt aaactgaagg     6180

cgggaaacga caatctccta ggttaggatt ttttttcacg aaattgcttc ttgaaattac     6240

gtgatggatt ttgattctga tttatcttgt gattgttgac tctacagatg cagatcttcg     6300

tcaagaccct caccggaaag accatcaccc ttgaggtgga aagctctgac accatcgaca     6360

acgtcaaggc caagatccag gacaaggaag gaattccccc ggatcagcaa cgtctcatct     6420

tcgccggaaa gcagctcgag gacggccgta ccctcgccga ctacaacatc cagaaggagt     6480

caacccttca ccttgtcctt cgtctccgtg gtggcatgca gatcttcgtc aagactctca     6540

ctggcaaaac cataacccta gaggtcgaaa gctctgacac cattgacaac gtcaaggcca     6600

agatccagga caaggaggga atccccccag accagcaacg tctcatcttc gccggaaagc     6660

aacttgagga cgggcgcacc ctcgccgact acaacatcca gaaggaatca acccttcacc     6720

tcgtcctccg tctccgtggt ggcatgcaga tcttcgttaa gaccctcacc ggcaagacta     6780

taaccctaga agtcgagagc tccgacacca tcgacaacgt caaggctaag atccaggaca     6840

aggagggtat ccccccagac cagcagaggc tgatcttcgc cggcaagcag ctcgaggacg     6900

gacgtaccct tgctgactac aacatccaga aggagtcaac tctccacttg gtgttgcgtc     6960

ttcgtggtgg tatgcagatc ttcgtcaaga cccttacggg taagactatt accctcgagg     7020

tggagagctc cgacaccatt gacaatgtga aggcgaagat ccaggacaag gaaggaatcc     7080

caccggacca gcagaggctt atttttgctg gcaaacagct agaggatgga aggaccctcg     7140

ctgactacaa catccagaag gagtcaactc tgcacttggt gttgcgtctt cgtggggggt     7200

tttcaaatgc tgctgatgaa gtggcaactc aattactgaa ttttgacctc ttgaagcttg     7260

ccggtgatgt tgagtctaac cctggaccaa tggcgcaagt tagcagaatc tgcaatggtg     7320

tgcagaaccc atctcttatc tccaatctct cgaaatccag tcaacgcaaa tctcccttat     7380

cggtttctct gaagacgcag cagcatccac gagcttatcc gatttcgtcg tcgtggggat     7440

tgaagaagag tgggatgacg ttaattggct ctgagcttcg tcctcttaag gtcatgtctt     7500

ctgtttccac ggcgtgcatg ggggaagcgg tgatcgccga agtatcgact caactatcag     7560

aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta catttgtacg     7620

gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg gttacggtga     7680

ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg gaaacttcgg     7740

cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt gtgcacgacg     7800

acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa tggcagcgca     7860

atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg gctatcttgc     7920

tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag gaactctttg     7980

atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg ctatggaact     8040

cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc cgcatttggt     8100

acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg gcaatggagc     8160

gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat cttggacaag     8220

aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac tacgtgaaag     8280

gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg atgtctgatg     8340

ttggattttc ccagacattt taagaagaaa tgtgatgtgt aatgggtctg taatgacctt     8400

tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact actgtttgtt     8460

atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg tgtttgaatt     8520

ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc atgcttatca     8580

cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga attattagat     8640

tttggtatta taggttaaag atatttatta ggtagggaga actcttggat tagattctaa     8700

agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat gatccctagt     8760

ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg tgaagcatat     8820

ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta attggcttgc     8880

ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc aattttagtt     8940

atgcaatctt tctgcttcag gtagtccttg tcttacagaa agcacattga gatgatcccc     9000

acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt aaaagatgta     9060

atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc aaaaaatacc     9120

aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat ttgattacca     9180

aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac tggaccccaa     9240

attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt taaaatccca     9300

tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacct aggctggcag     9360

cacatccccc gttcgcgagc tggcgtaaca gcgaagaggc ccgggcgcgc cactgttaat     9420

aatttttaaa cgtcagcgca ctaaaaaaac gaaaagacgg acacgtgaaa ataaaaaaca     9480

cacactagtt tatgacgcaa tactatttta cttatgattt gggtacatta gacaaaaccg     9540

tgaaagagat gtatcagcta tgaaacctgt atacttcaat acagagactt actcatatcg     9600

gatacgtacg cacgaagtat catattaatt attttaattt ttaataaata ttttatcgga     9660

tacttatgtg atactctaca tatacacaag gatatttcta agatacttta tagatacgta     9720

tcctagaaaa acatgaagag taaaaaagtg agacaatgtt gtaaaaattc attataaatg     9780

tatatgattc aattttagat atgcatcagt ataattgatt ctcgatgaaa cacttaaaat     9840

tatatttctt gtggaagaac gtagcgagag aggtgattca gttagacaac attaaataaa     9900

attaatgtta agttctttta atgatgtttc tctcaatatc acatcatatg aaaatgtaat     9960

atgatttata agaaaatttt taaaaaattt attttaataa tcacatgtac tattttttaa    10020

aaattgtatc ttttataata atacaataat aaagagtaat cagtgttaat ttttcttcaa    10080

atataagttt tattataaat cattgttaac gtatcataag tcattaccgt atcgtatctt    10140

aatttttttt taaaaaccgc taattcacgt acccgtattg tattgtaccc gcacctgtat    10200

cacaatcgat cttagttaga agaattgtct cgaggcggtg caagacagca tataatagac    10260

gtggactctc ttataccaaa cgttgtcgta tcacaaaggg ttaggtaaca agtcacagtt    10320

tgtccacgtg tcacgtttta attggaagag gtgccgttgg cgtaatataa cagccaatcg    10380

atttttgcta taaaagcaaa tcaggtaaac taaacttctt cattcttttc ttccccatcg    10440

ctacaaaacc ggttcctttg gaaaagagat tcattcaaac ctagcaccca attccgtttc    10500

aaggtataat ctactttcta ttcttcgatt attttattat tattagctac tatcgtttaa    10560

tcgatctttt cttttgatcc gtcaaattta aattcaatta gggttttgtt cttttctttc    10620

atctgattga aatccttctg aattgaaccg tttacttgat tttactgttt attgtatgat    10680

ttaatccttt gtttttcaaa gacagtcttt agattgtgat taggggttca tataaatttt    10740

tagatttgga tttttgtatt gtatgattca aaaaatacgt cctttaatta gattagtaca    10800

tggatatttt ttacccgatt tattgattgt cagggagaat ttgatgagca agtttttttg    10860

atgtctgttg taaattgaat tgattataat tgctgatctg ctgcttccag ttttcataac    10920

ccatattctt ttaaccttgt tgtacacaca atgaaaaatt ggtgattgat tcatttgttt    10980

ttctttgttt tggattatac agggtatggc gtccaagctg gagaagttta caaactgtta    11040

cagcctctcc aaaaccctca ggtttaaagc gatcccggtg ggcaagaccc aggagaacat    11100

cgacaacaag aggctcctgg tggaagacga gaagcgcgcc gaagactaca agggcgtgaa    11160

gaagctgctc gataggtact acctcagctt tattaacgac gtgctgcaca gcatcaaact    11220

caagaatctc aacaactaca tctccctctt ccgcaaaaag acccgcaccg agaaggagaa    11280

caaggagctg gagaacctgg agatcaacct ccgcaaggaa atcgccaaag cgttcaaggg    11340

caatgaaggg tacaagagcc tcttcaagaa agacatcatc gaaactatcc tcccagagtt    11400

tctcgatgac aaggacgaga tcgcgctggt gaactccttt aacgggttca caaccgcgtt    11460

taccggcttc tttgataaca gggaaaatat gttctccgag gaggccaagt ccaccagcat    11520

cgccttcagg tgtatcaacg agaacctcac ccgctacatt tccaatatgg acattttcga    11580

gaaggtggat gcgatcttcg ataagcacga ggtgcaggag atcaaagaga agattctcaa    11640

ttccgattat gacgtcgagg atttcttcga aggggagttc tttaattttg tgctcacaca    11700

agagggcatt gacgtgtaca acgcgattat cgggggcttc gtcacagagt ccggggagaa    11760

gattaagggg ctgaatgagt acatcaatct gtacaatcag aagaccaagc agaaactgcc    11820

gaaattcaag ccgctctaca agcaagtcct gtccgatagg gaaagcctct ccttctacgg    11880

cgagggctat accagcgacg aggaggtgct ggaagtcttc cgcaacacac tgaataagaa    11940

tagcgagatt ttctcctcca tcaagaagct cgagaagctc tttaagaact ttgacgagta    12000

cagctccgcc gggattttcg tgaagaacgg gccggcgatc agcaccatct ccaaggacat    12060

ctttggcgag tggaacgtca tcagggacaa gtggaacgcc gagtacgacg acatccacct    12120

gaagaagaag gcggtggtga ccgagaagta tgaggacgat cgcaggaagt ccttcaaaaa    12180

aatcggctcc ttcagcctcg aacagctcca ggagtatgcc gatgcggatc tgtccgtcgt    12240

cgagaagctg aaggaaatca tcattcagaa ggtcgacgag atctataaag tgtacgggtc    12300

cagcgagaag ctgttcgacg ccgactttgt gctcgagaag tccctcaaaa agaatgacgc    12360

cgtggtggcc attatgaaag acctgctcga ctccgtgaag tccttcgaaa attacattaa    12420

agcgttcttt ggggagggga aggaaactaa cagggatgag tccttctatg gcgactttgt    12480

cctcgcgtac gacatcctgc tgaaggtcga ccacatttac gacgcgatcc gcaactacgt    12540

gacacagaag ccgtactcca aagacaagtt caagctgtac ttccagaacc cgcaatttat    12600

ggggggctgg gacaaggata aagagacaga ctaccgcgcg acaattctcc gctatggctc    12660

caaatactat ctggccatca tggacaagaa gtacgcgaag tgcctgcaga agatcgacaa    12720

agacgacgtc aatggcaact atgaaaagat caactacaag ctgctgccgg gtccgaacaa    12780

gatgctcccg aaggtgttct tcagcaagaa gtggatggcc tactacaatc caagcgagga    12840

tattcagaaa atctataaaa acgggacctt caagaagggg gacatgttta acctcaacga    12900

ctgccacaag ctcattgatt tcttcaagga tagcatttcc cgctacccga aatggtccaa    12960

tgcgtacgat tttaacttct ccgagacaga aaagtacaaa gacatcgcgg gcttttacag    13020

ggaggtggag gagcaagggt ataaagtttc ttttgaatcc gcgagcaaga aggaagtcga    13080

caagctcgtc gaggagggca agctctacat gttccaaatt tataacaagg acttttccga    13140

caagagccat gggaccccaa acctccacac catgtacttc aaactgctct ttgacgagaa    13200

caaccacggg caaatcaggc tgagcggcgg cgccgaatta ttcatgcgca gggcctccct    13260

caagaaggaa gagctggtcg tccatccagc caattccccg atcgcgaaca agaacccgga    13320

caatccgaaa aagaccacca ccctgtccta cgacgtctac aaggacaaac gcttcagcga    13380

agaccagtac gaattacaca tcccaattgc gattaataag tgcccaaaga atatcttcaa    13440

aattaataca gaggtcaggg tgctgctcaa acacgacgac aatccgtatg tcatcggcat    13500

tgacaggggc gagcgcaatc tgctctatat cgtggtcgtg gatgggaagg gcaatattgt    13560

ggagcagtac tccctgaacg agattatcaa caacttcaat gggattagga ttaagaccga    13620

ctatcacagc ctgctcgaca agaaagaaaa agagaggttt gaggcccgcc aaaactggac    13680

ctccattgag aatatcaaag aattaaaggc cggctatatt tcccaagtcg tccacaagat    13740

ctgcgagctg gtggagaaat atgacgccgt gattgcgctc gaagacttaa attctgggtt    13800

caagaactcc cgcgtgaagg tggaaaaaca ggtgtatcag aaattcgaga aaatgctgat    13860

cgacaaactc aattatatgg tggataagaa gtccaacccg tgtgccacag ggggcgcgct    13920

gaagggctat cagatcacca acaagttcga gagcttcaag agcatgagca cccagaacgg    13980

gtttattttc tacatcccgg cgtggctcac ctccaagatt gacccgagca ccggcttcgt    14040

gaacctcctg aagacaaagt atacctccat tgccgacagc aagaagttta tctcctcctt    14100

cgaccgcatt atgtatgtgc cggaggagga cctcttcgag ttcgccctcg actacaaaaa    14160

cttcagccgc acagatgcgg attacatcaa gaagtggaag ctgtactcct acgggaacag    14220

gatccgcatc ttcaggaatc caaaaaaaaa taacgtcttt gactgggagg aagtgtgcct    14280

gacatccgcc tacaaggaac tgttcaataa atacggcatc aattaccagc agggcgacat    14340

tcgcgccctc ctctgtgagc agtccgacaa agcgttttac tccagcttca tggccctcat    14400

gtccctgatg ctccaaatga ggaatagcat cacagggcgc accgacgtcg acttcctcat    14460

cagcccggtg aagaactccg acgggatctt ttacgactcc cgcaactatg aggcgcaaga    14520

gaatgcgatc ctcccgaaga acgccgatgc gaacggggcc tataatatcg ccaggaaagt    14580

gctctgggcc atcgggcagt tcaaaaaggc ggaggatgag aagctcgaca aggtgaaaat    14640

tgccatttcc aacaaggagt ggctggagta cgcgcagacc tccgtgaagc acggctcctc    14700

cgagacacca ggcacctccg agagcgcgac gcccgagggc ggctccggcg gctccggcag    14760

cccgccgcct gccctccctc caaagaggcg aagaagtggt ggatcttccg gggggtcccc    14820

ccctcctgct ttacctccaa aaagacgtcg ttctggtggt tcaagtggag gttctccacc    14880

tcctgcactt cctcccaaga gaagaaggag cggcggcagc tcaggaggat caccaccacc    14940

agctttgcca cccaaaaggc gccggtgaaa gggctctctg tcatgatttc atactttcat    15000

tattgagctc tgtaattaca attatgacca tgagaacatc tcttattgtg tggcctttta    15060

attgctgatg ttagtactga accaaagctt atcgtgatga tgtaaaagca ataagtactt    15120

gtttgtagct tctttgtgtc tccctttggg cttaatacat ctgtttagtg ttgtggcttt    15180

ggcatagact tctcttggta ataatgcctt gcaatgcaaa atttcaatta tcaaattcta    15240

ttatgttctc accttatggt aacagcttac cctgtggaag atgagattct tgagttgagt    15300

cattgccaat ttttggcatt agcttttgaa ttagtgaatt ttgacaaaaa ttaccgtgac    15360

actgattttg ttgaagctct taagtgtagt ttttacaaaa tttcagtggc tcgttgtgat    15420

tatgtcaaac tcacggcgaa tgtagttctt acagaatttc agtggctccc tgcaggctcg    15480

aggtcattca tatgcttgag aagagagtcg ggatagtcca aaataaaaca aaggtaagat    15540

tacctggtca aaagtgaaaa catcagttaa aaggtggtat aaagtaaaat atcggtaata    15600

aaaggtggcc caaagtgaaa tttactcttt tctactatta taaaaattga ggatgttttt    15660

gtcggtactt tgatacgtca tttttgtatg aattggtttt taagtttatt cgcttttgga    15720

aatgcatatc tgtatttgag tcgggtttta agttcgtttg cttttgtaaa tacagaggga    15780

tttgtataag aaatatcttt agaaaaaccc atatgctaat ttgacataat ttttgagaaa    15840

aatatatatt caggcgaatt ctcacaatga acaataataa gattaaaata gctttccccc    15900

gttgcagcgc atgggtattt tttctagtaa aaataaaaga taaacttaga ctcaaaacat    15960

ttacaaaaac aacccctaaa gttcctaaag cccaaagtgc tatccacgat ccatagcaag    16020

cccagcccaa cccaacccaa cccaacccac cccagtccag ccaactggac aatagtctcc    16080

acaccccccc actatcaccg tgagttgtcc gcacgcaccg cacgtctcgc agccaaaaaa    16140

aaaaagaaag aaaaaaaaga aaaagaaaaa acagcaggtg ggtccgggtc gtgggggccg    16200

gaaacgcgag gaggatcgcg agccagcgac gaggagctta ggcctcatcg ttgaagatgc    16260

ctctgccgac agtggtccca aagatggacc cccacccacg aggagcatcg tggaaaaaga    16320

agacgttcca accacgtctt caaagcaagt ggattgatgt gatatctcca ctgacgtaag    16380

ggatgacgca caatcccact atccttcgag gcctcatcgt tgaagatgcc tctgccgaca    16440

gtggtcccaa agatggaccc ccacccacga ggagcatcgt ggaaaaagaa gacgttccaa    16500

ccacgtcttc aaagcaagtg gattgatgtg atatctccac tgacgtaagg gatgacgcac    16560

aatcccacta tccttcgaag ctccctccct ccgcttccaa agaaacgccc cccatcgcca    16620

ctatatacat acccccccct ctcctcccat ccccccaacc cttctagaac catcttccac    16680

acactcaagc cacactattg gagaacacac agggacaaca caccataaga tccaagggag    16740

gcctccgccg ccgccggtaa ccaccccgcc cctctcctct ttctttctcc gttttttttt    16800

ccgtctcggt ctcgatcttt ggccttggta gtttgggtgg gcgagaggcg gcttcgtgcg    16860

cgcccagatc ggtgcgcggg aggggcggga tctcgcggct ggggctctcg ccggcgtgga    16920

tccggcccgg atctcgcggg gaatggggct ctcggatgta gatctgcgat ccgccgttgt    16980

tgggggagat gatggggggt ttaaaatttc cgccgtgcta aacaagatca ggaagagggg    17040

aaaagggcac tatggtttat atttttatat atttctgctg cttcgtcagg cttagatgtg    17100

ctagatcttt ctttcttctt tttgtgggta gaatttgaat ccctcagcat tgttcatcgg    17160

tagtttttct tttcatgatt tgtgacaaat gcagcctcgt gcggagcttt tttgtaggta    17220

gaaggcggcc gcatggccca gtctaagcac gggttgacga aggagatgac tatgaagtat    17280

cgcatggaag gctgcgttga cggccacaaa ttcgtcatta ccggcgaggg catcggctac    17340

ccctttaagg taagtttctg cttctacctt tgatatatat ataataatta tcattaatta    17400

gtagtaatat aatatttcaa atattttttt caaaataaaa gaatgtagta tatagcaatt    17460

gcttttctgt agtttataag tgtgtatatt ttaatttata acttttctaa tatatgacca    17520

aaatttgttg atgtgcaggg caagcaagcg ataaacctgt gcgtggtgga gggtggccct    17580

ctgcccttcg ccgaggatat actctcagcc gccttcatgt acgggaatcg ggtgttcacg    17640

gagtacccgc aagacatcgt ggactacttc aagaactcct gccccgccgg atacacatgg    17700

gaccgttcct tcctcttcga ggacggagcc gtttgcatct gcaacgcgga catcaccgtg    17760

tccgtcgagg agaactgcat gtaccacgag tcaaagttct atggagtgaa cttcccggcc    17820

gatggtcccg tgatgaagaa aatgacggac aactgggagc cgtcgtgcga gaaaatcatt    17880

cccgtcccaa aacagggaat cctcaagggc gacgtgtcga tgtacctact tctcaaggac    17940

ggtggacggc tacggtgcca gttcgacact gtttacaagg cgaagtcggt gccgaggaag    18000

atgccggact ggcactttat ccagcacaag ctgacaaggg aggacagaag cgacgctaag    18060

aaccagaaat ggcacctcac cgagcacgcc atcgccagtg gctctgcgct gcccgggtga    18120

ccctgcaatg tgaccctaga cttgtccatc ttctggattg gccaacttaa ttaatgtatg    18180

aaataaaagg atgcacacat agtgacatgc taatcactat aatgtgggca tcaaagttgt    18240

gtgttatgtg taattactaa ttatctgaat aagagaaaga gatcatccat atttcttatc    18300

ctaaatgaat gtcacgtgtc tttataattc tttgatgaac cagatgcatt ttattaacca    18360

attccatata catataaata ttaatcatat ataattaata tcaattgggt tagcaaaaca    18420

aatctagtct aggtgtgttt tgctaattat tgggggatag tgcaaaaaga aatctacgtt    18480

ctcaataatt cagatagaaa acttaataaa gtgagataat ttacatagat tgcttttatc    18540

ctttgatata tgtgaaacca tgcatgatat aaggaaaata gatagagaaa taatttttta    18600

catcgttgaa tatgtaaaca atttaattca agaagctagg aatataaata ttgaggagtt    18660

tatgattatt attattattt tgatgttcaa tgaagttttt tttaatttca tatgaagtat    18720

acaaaaattc ttcatagatt tttgtttcta tgccgtagtt atctttaata tatttgtggt    18780

tgaagaaatt tattgctaga aacgaatgga ttgtcaattt ttttttaaag caaatatata    18840

tgaaattata ctgtatatta ttttagtcat gattaaaatg tggccttaat tgaatcatct    18900

ttctcattca ttttttcaaa agcatatcag gatgattgat atttatctat tttaaaaatt    18960

aatttaaggg ttcaaattaa atttaactta aaagtgtcct aaccgtagtt aaaggtttac    19020

tttaaaaaaa tactatgaaa aatctaatct tctatgaatc gagggccctt agctagttag    19080


<210>  97
<211>  526
<212>  DNA
<213>  Agrobacterium tumefaciens

<400>  97
ggagactcga ccagggtaat cagcacgtct gttcggcgcg cctatagcta tggtttctcg       60

caatcgcttt gggcagtcgg ttgtggcggt gcgtcttctg agacccgaag gttggcgatt      120

atctgctgga ggtcttcgat accgtcttcg aagaacaaga catatgttcg ctgagctcgg      180

acataggata gtcggcatag gcggataccc tcgccacgca aatggcgcga tcgacaccct      240

gatcggagcc tgcgaagtgc cacagtttat tggaaccatc ccccgttcat tccgccctgg      300

aatttcactt cgacggcatt ctagatcctc gccgttgtct tagagagcca tctttcgtcg      360

gcgcaccctt aagtgcatgg aaagccgttt tcgcttcaaa tgaaatcgaa aagaagaaaa      420

caaaaatcct agagtaaccg accctcccga taatcgtgaa catcagatga cagcatttct      480

tccgaccgaa gtggctgtgt tggttatgag cttggggaga tgggga                     526


<210>  98
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Simian virus 40 (NLS) , Agrobacterium tumefaciens (VirD2), 
       synthetic (Linker and SH3) fusion

<400>  98
atgagcggat caaaaaaaag aaggatcaag caagatgcgg agtacgtgcg tgctttgttt       60

gatttcaacg gcaacgatga agaagacctg ccattcaaaa agggcgacat cctgcgtatt      120

cgtgataaac cggaagagca gtggtggaat gcagaggaca gcgaaggtaa gcgcggtatg      180

atcccggttc cgtatgtcga gaagtactcc ggtggaagtt ccggaggttc aagcgggtct      240

gaaacgccgg gcaccagcga gtcggcgacc ccggaaagca gcggtggttc ttccggcggt      300

agcatgcccg atcgagctca agttatcatt cgcattgtgc cgggaggtgg caccaagacc      360

cttcaacaaa ttatcaatca gttggagtat ctatcccgga agggcaggct ggagctgcag      420

cgttcagccc gacatctcga tattcccctg ccaccggatc aaatccacga acttgcccga      480

agctgggttc aagagactgg aacttatgac gaaagtcagc cagacgagga aaggcaacag      540

gagttgacca cccatattat tgtaagcttc cccgccggta caagccaggt agcggcttat      600

gcggcgagcc gggagtgggc agccgagatg tttgggtcag gcgcaggggg gggccgatac      660

aactatctta cggccttcca catcgatcgc gaccacccac atctgcatgt cgtcgtcaat      720

cggcgcgaac ttttaggaca cggctggctg aagatatctc ggcgccatcc ccaactgaat      780

tacgacgccc tgcgcataaa gatggccgag atttcacttc gtcatggcat tgccctcgat      840

gcgagccgac gagcagaacg tggcatcacc gagcggccga tcacttatgc ccaatatcgg      900

cgccttgagc gggagcaggc tcgccaaatc cgtttcgaag acgcggattt ggaacagtcg      960

tcgccgcaag gagatcatcc agaattcagc caacctttcg atacatcccc atttgaagca     1020

tccgcgggcg gaccggagga catgcctcgg cccaacaatc ggcagaatga gtcgcaagtt     1080

catctccagg agccagctgg tgtcagcaac gaagccggtg tccttgtgcg ggttgcattg     1140

gaaacggagc gccttgctca accattcgtt tccgaaacca ttctcgcgga cgacataggg     1200

agcggctctt cgcgtgttgc cgagggccgt gtggagagcg caaaccgcac tcccgatatt     1260

cctcgcgcag caactgaagc tgccacgcac acgacacacg accggcagcg gcgtgcaaag     1320

cgtcctcatg atgacgacgg agggccgagt ggagcaaaac gtgtgacatt ggaaggcatc     1380

gcggttgggc cccaggcgaa cgccggcgaa caggatggca gtagtggccc cttagtacgg     1440

caagctggaa cgtcacggcc atctccaccg acggccacga cgcgggccag caccgcaacc     1500

gattcattgt ctgctacagc ccacctccag caacggagag gtgtcctttc aaagcgtccg     1560

cgtgaagatg atgatggaga accgagtgaa cgcaaacgcg agagagatga gcgcagcaag     1620

gacgggcgtg ggggaaatag gagatag                                         1647


<210>  99
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Simian virus 40 (NLS) , Agrobacterium tumefaciens (VirD2), 
       synthetic (Linker), Homo sapiens (SH3) fusion

<400>  99

Met Ser Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Ala Glu Tyr Val 
1               5                   10                  15      


Arg Ala Leu Phe Asp Phe Asn Gly Asn Asp Glu Glu Asp Leu Pro Phe 
            20                  25                  30          


Lys Lys Gly Asp Ile Leu Arg Ile Arg Asp Lys Pro Glu Glu Gln Trp 
        35                  40                  45              


Trp Asn Ala Glu Asp Ser Glu Gly Lys Arg Gly Met Ile Pro Val Pro 
    50                  55                  60                  


Tyr Val Glu Lys Tyr Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser 
65                  70                  75                  80  


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly 
                85                  90                  95      


Ser Ser Gly Gly Ser Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile 
            100                 105                 110         


Val Pro Gly Gly Gly Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu 
        115                 120                 125             


Glu Tyr Leu Ser Arg Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg 
    130                 135                 140                 


His Leu Asp Ile Pro Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg 
145                 150                 155                 160 


Ser Trp Val Gln Glu Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu 
                165                 170                 175     


Glu Arg Gln Gln Glu Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala 
            180                 185                 190         


Gly Thr Ser Gln Val Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala 
        195                 200                 205             


Glu Met Phe Gly Ser Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr 
    210                 215                 220                 


Ala Phe His Ile Asp Arg Asp His Pro His Leu His Val Val Val Asn 
225                 230                 235                 240 


Arg Arg Glu Leu Leu Gly His Gly Trp Leu Lys Ile Ser Arg Arg His 
                245                 250                 255     


Pro Gln Leu Asn Tyr Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser 
            260                 265                 270         


Leu Arg His Gly Ile Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly 
        275                 280                 285             


Ile Thr Glu Arg Pro Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg 
    290                 295                 300                 


Glu Gln Ala Arg Gln Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser 
305                 310                 315                 320 


Ser Pro Gln Gly Asp His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser 
                325                 330                 335     


Pro Phe Glu Ala Ser Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn 
            340                 345                 350         


Asn Arg Gln Asn Glu Ser Gln Val His Leu Gln Glu Pro Ala Gly Val 
        355                 360                 365             


Ser Asn Glu Ala Gly Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg 
    370                 375                 380                 


Leu Ala Gln Pro Phe Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly 
385                 390                 395                 400 


Ser Gly Ser Ser Arg Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg 
                405                 410                 415     


Thr Pro Asp Ile Pro Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr 
            420                 425                 430         


His Asp Arg Gln Arg Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly 
        435                 440                 445             


Pro Ser Gly Ala Lys Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro 
    450                 455                 460                 


Gln Ala Asn Ala Gly Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg 
465                 470                 475                 480 


Gln Ala Gly Thr Ser Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala 
                485                 490                 495     


Ser Thr Ala Thr Asp Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg 
            500                 505                 510         


Arg Gly Val Leu Ser Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro 
        515                 520                 525             


Ser Glu Arg Lys Arg Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly 
    530                 535                 540                 


Gly Asn Arg Arg 
545             


<210>  100
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ost1 HDR template - sense orientation

<400>  100
aaaagattga cacattgcct atactacatt ctagcgtagg ttaaatttat atcagataat       60

gtgggagaaa gagatcagtt accattgcat gacaatagct gaccccagat atgagttgtt      120

gaaagaagaa acgagcctgt ggcatgacaa tgggttaata gttacacagg aaatagagag      180

ctagcacaag caaaagtaaa caaattgtat aagaacctca tcctcattaa aacgccctgc      240

attgcagatt ttctcaaata gttctccacc agatgcatat tccattacaa tgtctagatg      300

agtcggtgtt agaataacct gagtcaaata tcaaagaaca ttttccatga atatgattat      360

tgtacctctg aacataaaaa tatataaata caaatatata ccaacctcct taaacctgat      420

aatgttagga tgtcttagag acctgtgatt aatgatttct cttttaacat tttcatcaat      480

ctgtgacaca cagcaaatga taggg                                            505


<210>  101
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ost1 HDR template - antisense orientation

<400>  101
ccctatcatt tgctgtgtgt cacagattga tgaaaatgtt aaaagagaaa tcattaatca       60

caggtctcta agacatccta acattatcag gtttaaggag gttggtatat atttgtattt      120

atatattttt atgttcagag gtacaataat catattcatg gaaaatgttc tttgatattt      180

gactcaggtt attctaacac cgactcatct agacattgta atggaatatg catctggtgg      240

agaactattt gagaaaatct gcaatgcagg gcgttttaat gaggatgagg ttcttataca      300

atttgtttac ttttgcttgt gctagctctc tatttcctgt gtaactatta acccattgtc      360

atgccacagg ctcgtttctt ctttcaacaa ctcatatctg gggtcagcta ttgtcatgca      420

atggtaactg atctctttct cccacattat ctgatataaa tttaacctac gctagaatgt      480

agtataggca atgtgtcaat ctttt                                            505


<210>  102
<211>  3149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha HDR template with aadA insertion

<400>  102
ttggtgtgaa acagatgatt tgctgctgta acaaagtaaa ttatgtctcg acttttaagg       60

cccctttcat tttattagat tattttattt taattaatgt tcttgtccca ttttgcaaca      120

gatggatgct actacaccca agtattccaa ggccaggtat gatgaaattg tgaaggaagt      180

ctcttcctac ttgaagaaag taggatacaa ccctgacaag attccttttg ttcctatctc      240

tggttttgag ggagacaaca tgattgagag gtccacaaac cttgactggt acaagggtcc      300

aactctgctt gatgcacttg accagattag tgagcccaag aggccctctg acaagcccct      360

caggcttccc cttcaggatg tgtacaagat tggaggtatt ggaactgtgc cagtgggacg      420

tgttgagacc ggtgtcttga agcctggaat ggtggtgact tttgcaccaa ctggactgac      480

aactgaagtc aagtctgtgg agatgcacca tgaatctctt acagaggcac atcctggtga      540

caatgtggga ttcaatgtta agaatgttgc tgttaaggat ttgaagcgtg gttatgttgc      600

ctcaaactca aaggatgacc ctgcaaagga ggctgctaac ttcacagccc aagtcatcat      660

catgaaccac cctggtcaga ttggaaatgg ctatgcccct gtcctcgact gccacacttc      720

tcacattgct gtcaagtttg ctgaactcat gaccaagatt gacaggcgat ccggcaaaga      780

gcttgagaag gagcccaagt ttttgaagaa cggtgatgct ggttttgtta agatgattcc      840

aaccaaaccc atggttgttg aaactttctc cgagtatcct ccacttggta ggtttgctgt      900

tagggacatg cgtcaaactg ttgctgtggg agtcatcaag aacgttgaga agaaggatcc      960

taccggagcc aaggtcacca aggctgccca gaagaagaag tcaaatgctg ctgatgaagt     1020

ggcaactcaa ttactgaatt ttgacctctt gaagcttgcc ggtgatgttg agtctaaccc     1080

tggaccaatg gcgcaagtta gcagaatctg caatggtgtg cagaacccat ctcttatctc     1140

caatctctcg aaatccagtc aacgcaaatc tcccttatcg gtttctctga agacgcagca     1200

gcatccacga gcttatccga tttcgtcgtc gtggggattg aagaagagtg ggatgacgtt     1260

aattggctct gagcttcgtc ctcttaaggt catgtcttct gtttccacgg cgtgcatggg     1320

ggaagcggtg atcgccgaag tatcgactca actatcagag gtagttggcg tcatcgagcg     1380

ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc tccgcagtgg atggcggcct     1440

gaagccacac agtgatattg atttgctggt tacggtgacc gtaaggcttg atgaaacaac     1500

gcggcgagct ttgatcaacg accttttgga aacttcggct tcccctggag agagcgagat     1560

tctccgcgct gtagaagtca ccattgttgt gcacgacgac atcattccgt ggcgttatcc     1620

agctaagcgc gaactgcaat ttggagaatg gcagcgcaat gacattcttg caggtatctt     1680

cgagccagcc acgatcgaca ttgatctggc tatcttgctg acaaaagcaa gagaacatag     1740

cgttgccttg gtaggtccag cggcggagga actctttgat ccggttcctg aacaggatct     1800

atttgaggcg ctaaatgaaa ccttaacgct atggaactcg ccgcccgact gggctggcga     1860

tgagcgaaat gtagtgctta cgttgtcccg catttggtac agcgcagtaa ccggcaaaat     1920

cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc ctgccggccc agtatcagcc     1980

cgtcatactt gaagctagac aggcttatct tggacaagaa gaagatcgct tggcctcgcg     2040

cgcagatcag ttggaagaat ttgtccacta cgtgaaaggc gagatcacca aggtagtcgg     2100

caaatgaatc gtgcgggctg gttcatcagg gaatgttggc tacaatcaat gttggtttct     2160

tttctgtact cttgtgtctt cttttctagg tagcttgttt ttcggacaaa gtttgaagtc     2220

tccaccatca tctcgcaact gttgttccca gaactgggtt cttgatcgac ggtggcaaaa     2280

ttgcttttat ttatctgtgt tttaatgtgt tgtgtttgtc ggaacccctg attacatttt     2340

tgttaagcgc agcgagtttc aggactttgc tgcgttgtgt tgctttggtt tattaaatgt     2400

caactttcta tttgtagtgt tcaatttttg gcttggtttg ctttttcttt ataatttgtg     2460

ttcaaatttt ggcttggttt gcttttacta taatttgtgt tcaaattttg ggttggattt     2520

tttaacgatc ggctgtttgc tcttcttcct ctgttttgat gtgttcgtga ctatgcaaga     2580

atcttcaatt ttgctaaaat aaacttgctt tgacaacata gaatcaaatc cgagtgcttt     2640

aatattcggt ggtttgtttt tatttttggt tttatgaaag ttaaaatttt aaaagtaaat     2700

cgataaggta taattgtggt ttttatttat cgagaatttt ttaagtgaat cgatataatt     2760

tatttcccct aaaataaaat accaaagaat cgaattcgaa ctttgtcttt aataaaacta     2820

ctaatttaat cattatttgt tctgtgtaag catgagaaat aaattctact tatcttttag     2880

tttaaaacca aaacaggtta agaataattt ttctaaggcc gttatcaagg tcaccaaaaa     2940

tctattcgat ctgaccatat attttcgata cttgtacgat tcgcagatgt tgattggaaa     3000

ttgcaatgaa taaattacaa atgccaaatc cgattatgca atgaatgaat tacaagtgca     3060

tttatccgtt ttgaatctgt tcatgtctac caatgggaga gatttttttc ctgcatctgc     3120

catacatatg ggaagaccga aaatacttt                                       3149


<210>  103
<211>  3149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha HDR template with aadA insertion

<400>  103
aaagtatttt cggtcttccc atatgtatgg cagatgcagg aaaaaaatct ctcccattgg       60

tagacatgaa cagattcaaa acggataaat gcacttgtaa ttcattcatt gcataatcgg      120

atttggcatt tgtaatttat tcattgcaat ttccaatcaa catctgcgaa tcgtacaagt      180

atcgaaaata tatggtcaga tcgaatagat ttttggtgac cttgataacg gccttagaaa      240

aattattctt aacctgtttt ggttttaaac taaaagataa gtagaattta tttctcatgc      300

ttacacagaa caaataatga ttaaattagt agttttatta aagacaaagt tcgaattcga      360

ttctttggta ttttatttta ggggaaataa attatatcga ttcacttaaa aaattctcga      420

taaataaaaa ccacaattat accttatcga tttactttta aaattttaac tttcataaaa      480

ccaaaaataa aaacaaacca ccgaatatta aagcactcgg atttgattct atgttgtcaa      540

agcaagttta ttttagcaaa attgaagatt cttgcatagt cacgaacaca tcaaaacaga      600

ggaagaagag caaacagccg atcgttaaaa aatccaaccc aaaatttgaa cacaaattat      660

agtaaaagca aaccaagcca aaatttgaac acaaattata aagaaaaagc aaaccaagcc      720

aaaaattgaa cactacaaat agaaagttga catttaataa accaaagcaa cacaacgcag      780

caaagtcctg aaactcgctg cgcttaacaa aaatgtaatc aggggttccg acaaacacaa      840

cacattaaaa cacagataaa taaaagcaat tttgccaccg tcgatcaaga acccagttct      900

gggaacaaca gttgcgagat gatggtggag acttcaaact ttgtccgaaa aacaagctac      960

ctagaaaaga agacacaaga gtacagaaaa gaaaccaaca ttgattgtag ccaacattcc     1020

ctgatgaacc agcccgcacg attcatttgc cgactacctt ggtgatctcg cctttcacgt     1080

agtggacaaa ttcttccaac tgatctgcgc gcgaggccaa gcgatcttct tcttgtccaa     1140

gataagcctg tctagcttca agtatgacgg gctgatactg ggccggcagg cgctccattg     1200

cccagtcggc agcgacatcc ttcggcgcga ttttgccggt tactgcgctg taccaaatgc     1260

gggacaacgt aagcactaca tttcgctcat cgccagccca gtcgggcggc gagttccata     1320

gcgttaaggt ttcatttagc gcctcaaata gatcctgttc aggaaccgga tcaaagagtt     1380

cctccgccgc tggacctacc aaggcaacgc tatgttctct tgcttttgtc agcaagatag     1440

ccagatcaat gtcgatcgtg gctggctcga agatacctgc aagaatgtca ttgcgctgcc     1500

attctccaaa ttgcagttcg cgcttagctg gataacgcca cggaatgatg tcgtcgtgca     1560

caacaatggt gacttctaca gcgcggagaa tctcgctctc tccaggggaa gccgaagttt     1620

ccaaaaggtc gttgatcaaa gctcgccgcg ttgtttcatc aagccttacg gtcaccgtaa     1680

ccagcaaatc aatatcactg tgtggcttca ggccgccatc cactgcggag ccgtacaaat     1740

gtacggccag caacgtcggt tcgagatggc gctcgatgac gccaactacc tctgatagtt     1800

gagtcgatac ttcggcgatc accgcttccc ccatgcacgc cgtggaaaca gaagacatga     1860

ccttaagagg acgaagctca gagccaatta acgtcatccc actcttcttc aatccccacg     1920

acgacgaaat cggataagct cgtggatgct gctgcgtctt cagagaaacc gataagggag     1980

atttgcgttg actggatttc gagagattgg agataagaga tgggttctgc acaccattgc     2040

agattctgct aacttgcgcc attggtccag ggttagactc aacatcaccg gcaagcttca     2100

agaggtcaaa attcagtaat tgagttgcca cttcatcagc agcatttgac ttcttcttct     2160

gggcagcctt ggtgaccttg gctccggtag gatccttctt ctcaacgttc ttgatgactc     2220

ccacagcaac agtttgacgc atgtccctaa cagcaaacct accaagtgga ggatactcgg     2280

agaaagtttc aacaaccatg ggtttggttg gaatcatctt aacaaaacca gcatcaccgt     2340

tcttcaaaaa cttgggctcc ttctcaagct ctttgccgga tcgcctgtca atcttggtca     2400

tgagttcagc aaacttgaca gcaatgtgag aagtgtggca gtcgaggaca ggggcatagc     2460

catttccaat ctgaccaggg tggttcatga tgatgacttg ggctgtgaag ttagcagcct     2520

cctttgcagg gtcatccttt gagtttgagg caacataacc acgcttcaaa tccttaacag     2580

caacattctt aacattgaat cccacattgt caccaggatg tgcctctgta agagattcat     2640

ggtgcatctc cacagacttg acttcagttg tcagtccagt tggtgcaaaa gtcaccacca     2700

ttccaggctt caagacaccg gtctcaacac gtcccactgg cacagttcca atacctccaa     2760

tcttgtacac atcctgaagg ggaagcctga ggggcttgtc agagggcctc ttgggctcac     2820

taatctggtc aagtgcatca agcagagttg gacccttgta ccagtcaagg tttgtggacc     2880

tctcaatcat gttgtctccc tcaaaaccag agataggaac aaaaggaatc ttgtcagggt     2940

tgtatcctac tttcttcaag taggaagaga cttccttcac aatttcatca tacctggcct     3000

tggaatactt gggtgtagta gcatccatct gttgcaaaat gggacaagaa cattaattaa     3060

aataaaataa tctaataaaa tgaaaggggc cttaaaagtc gagacataat ttactttgtt     3120

acagcagcaa atcatctgtt tcacaccaa                                       3149


<210>  104
<211>  3145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin HDR template with aadA insertion

<400>  104
ttaggatttt ttttcacgaa attgcttctt gaaattacgt gatggatttt gattctgatt       60

tatcttgtga ttgttgactc tacagatgca gatcttcgtc aagaccctca ccggaaagac      120

catcaccctt gaggtggaaa gctctgacac catcgacaac gtcaaggcca agatccagga      180

caaggaagga attcccccgg atcagcaacg tctcatcttc gccggaaagc agctcgagga      240

cggccgtacc ctcgccgact acaacatcca gaaggagtca acccttcacc ttgtccttcg      300

tctccgtggt ggcatgcaga tcttcgtcaa gactctcact ggcaaaacca taaccctaga      360

ggtcgaaagc tctgacacca ttgacaacgt caaggccaag atccaggaca aggagggaat      420

ccccccagac cagcaacgtc tcatcttcgc cggaaagcaa cttgaggacg ggcgcaccct      480

cgccgactac aacatccaga aggaatcaac ccttcacctc gtcctccgtc tccgtggtgg      540

catgcagatc ttcgttaaga ccctcaccgg caagactata accctagaag tcgagagctc      600

cgacaccatc gacaacgtca aggctaagat ccaggacaag gagggtatcc ccccagacca      660

gcagaggctg atcttcgccg gcaagcagct cgaggacgga cgtacccttg ctgactacaa      720

catccagaag gagtcaactc tccacttggt gttgcgtctt cgtggtggta tgcagatctt      780

cgtcaagacc cttacgggta agactattac cctcgaggtg gagagctccg acaccattga      840

caatgtgaag gcgaagatcc aggacaagga aggaatccca ccggaccagc agaggcttat      900

ttttgctggc aaacagctag aggatggaag gaccctcgct gactacaaca tccagaagga      960

gtcaactctg cacttggtgt tgcgtcttcg tggggggttt tcaaatgctg ctgatgaagt     1020

ggcaactcaa ttactgaatt ttgacctctt gaagcttgcc ggtgatgttg agtctaaccc     1080

tggaccaatg gcgcaagtta gcagaatctg caatggtgtg cagaacccat ctcttatctc     1140

caatctctcg aaatccagtc aacgcaaatc tcccttatcg gtttctctga agacgcagca     1200

gcatccacga gcttatccga tttcgtcgtc gtggggattg aagaagagtg ggatgacgtt     1260

aattggctct gagcttcgtc ctcttaaggt catgtcttct gtttccacgg cgtgcatggg     1320

ggaagcggtg atcgccgaag tatcgactca actatcagag gtagttggcg tcatcgagcg     1380

ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc tccgcagtgg atggcggcct     1440

gaagccacac agtgatattg atttgctggt tacggtgacc gtaaggcttg atgaaacaac     1500

gcggcgagct ttgatcaacg accttttgga aacttcggct tcccctggag agagcgagat     1560

tctccgcgct gtagaagtca ccattgttgt gcacgacgac atcattccgt ggcgttatcc     1620

agctaagcgc gaactgcaat ttggagaatg gcagcgcaat gacattcttg caggtatctt     1680

cgagccagcc acgatcgaca ttgatctggc tatcttgctg acaaaagcaa gagaacatag     1740

cgttgccttg gtaggtccag cggcggagga actctttgat ccggttcctg aacaggatct     1800

atttgaggcg ctaaatgaaa ccttaacgct atggaactcg ccgcccgact gggctggcga     1860

tgagcgaaat gtagtgctta cgttgtcccg catttggtac agcgcagtaa ccggcaaaat     1920

cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc ctgccggccc agtatcagcc     1980

cgtcatactt gaagctagac aggcttatct tggacaagaa gaagatcgct tggcctcgcg     2040

cgcagatcag ttggaagaat ttgtccacta cgtgaaaggc gagatcacca aggtagtcgg     2100

caaataagct ggagctgatg tctgtgtgat gtctgatgtt ggattttccc agacatttta     2160

agaagaaatg tgatgtgtaa tgggtctgta atgacctttg aaaataagtt tggtttgtgt     2220

tgaactctat tgtcccatta atgttactac tgtttgttat caatttgtgg agctgatata     2280

taattatcaa ctgtatgctg gcatattgtg tttgaatttt gttctcaatc cagtgaattg     2340

gcgtatatta gtgggttttt tattcttcat gcttatcacg gaggaaaagc agggatgagt     2400

tgtgtgaagg atggtgatca tcccacgaat tattagattt tggtattata ggttaaagat     2460

atttattagg tagggagaac tcttggatta gattctaaag tgatattttg aaaacacacc     2520

aaaggatttt tgaacaaacg gagatcatga tccctagttt caattagctg ccccttacca     2580

agaggtagca acttaaaaat tatgctcgtg aagcatattt ggtatcgtat ataaattatg     2640

taagcaatct gcttcagttg gaacattaat tggcttgcgg aatgcacatt tagatgatcc     2700

acacaggtcc acataaaaat tcctaatcaa ttttagttat gcaatctttc tgcttcaggt     2760

agtccttgtc ttacagaaag cacattgaga tgatccccac acagatccac ataaaaaatt     2820

cctaatcaat aataacttga aaatcattaa aagatgtaat gccatactaa tccctaattt     2880

ttgtgcaagt ttttgtatac tggaccccaa aaaataccaa aaagaaaaaa caagttattc     2940

agtgatattt ttctgctcca atataaattt gattaccaaa taccaaaaaa taaaaacact     3000

attcagtggt atttttctgc tccaatactg gaccccaaat taatcagaat cggatccgtt     3060

taacagataa aaacaaaagc gatcgggtta aaatcccatt tttacaaata acaacgcagg     3120

tttatacatg aaacaaatgt catta                                           3145


<210>  105
<211>  3145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin HDR template with aadA insertion

<400>  105
taatgacatt tgtttcatgt ataaacctgc gttgttattt gtaaaaatgg gattttaacc       60

cgatcgcttt tgtttttatc tgttaaacgg atccgattct gattaatttg gggtccagta      120

ttggagcaga aaaataccac tgaatagtgt ttttattttt tggtatttgg taatcaaatt      180

tatattggag cagaaaaata tcactgaata acttgttttt tctttttggt attttttggg      240

gtccagtata caaaaacttg cacaaaaatt agggattagt atggcattac atcttttaat      300

gattttcaag ttattattga ttaggaattt tttatgtgga tctgtgtggg gatcatctca      360

atgtgctttc tgtaagacaa ggactacctg aagcagaaag attgcataac taaaattgat      420

taggaatttt tatgtggacc tgtgtggatc atctaaatgt gcattccgca agccaattaa      480

tgttccaact gaagcagatt gcttacataa tttatatacg ataccaaata tgcttcacga      540

gcataatttt taagttgcta cctcttggta aggggcagct aattgaaact agggatcatg      600

atctccgttt gttcaaaaat cctttggtgt gttttcaaaa tatcacttta gaatctaatc      660

caagagttct ccctacctaa taaatatctt taacctataa taccaaaatc taataattcg      720

tgggatgatc accatccttc acacaactca tccctgcttt tcctccgtga taagcatgaa      780

gaataaaaaa cccactaata tacgccaatt cactggattg agaacaaaat tcaaacacaa      840

tatgccagca tacagttgat aattatatat cagctccaca aattgataac aaacagtagt      900

aacattaatg ggacaataga gttcaacaca aaccaaactt attttcaaag gtcattacag      960

acccattaca catcacattt cttcttaaaa tgtctgggaa aatccaacat cagacatcac     1020

acagacatca gctccagctt atttgccgac taccttggtg atctcgcctt tcacgtagtg     1080

gacaaattct tccaactgat ctgcgcgcga ggccaagcga tcttcttctt gtccaagata     1140

agcctgtcta gcttcaagta tgacgggctg atactgggcc ggcaggcgct ccattgccca     1200

gtcggcagcg acatccttcg gcgcgatttt gccggttact gcgctgtacc aaatgcggga     1260

caacgtaagc actacatttc gctcatcgcc agcccagtcg ggcggcgagt tccatagcgt     1320

taaggtttca tttagcgcct caaatagatc ctgttcagga accggatcaa agagttcctc     1380

cgccgctgga cctaccaagg caacgctatg ttctcttgct tttgtcagca agatagccag     1440

atcaatgtcg atcgtggctg gctcgaagat acctgcaaga atgtcattgc gctgccattc     1500

tccaaattgc agttcgcgct tagctggata acgccacgga atgatgtcgt cgtgcacaac     1560

aatggtgact tctacagcgc ggagaatctc gctctctcca ggggaagccg aagtttccaa     1620

aaggtcgttg atcaaagctc gccgcgttgt ttcatcaagc cttacggtca ccgtaaccag     1680

caaatcaata tcactgtgtg gcttcaggcc gccatccact gcggagccgt acaaatgtac     1740

ggccagcaac gtcggttcga gatggcgctc gatgacgcca actacctctg atagttgagt     1800

cgatacttcg gcgatcaccg cttcccccat gcacgccgtg gaaacagaag acatgacctt     1860

aagaggacga agctcagagc caattaacgt catcccactc ttcttcaatc cccacgacga     1920

cgaaatcgga taagctcgtg gatgctgctg cgtcttcaga gaaaccgata agggagattt     1980

gcgttgactg gatttcgaga gattggagat aagagatggg ttctgcacac cattgcagat     2040

tctgctaact tgcgccattg gtccagggtt agactcaaca tcaccggcaa gcttcaagag     2100

gtcaaaattc agtaattgag ttgccacttc atcagcagca tttgaaaacc ccccacgaag     2160

acgcaacacc aagtgcagag ttgactcctt ctggatgttg tagtcagcga gggtccttcc     2220

atcctctagc tgtttgccag caaaaataag cctctgctgg tccggtggga ttccttcctt     2280

gtcctggatc ttcgccttca cattgtcaat ggtgtcggag ctctccacct cgagggtaat     2340

agtcttaccc gtaagggtct tgacgaagat ctgcatacca ccacgaagac gcaacaccaa     2400

gtggagagtt gactccttct ggatgttgta gtcagcaagg gtacgtccgt cctcgagctg     2460

cttgccggcg aagatcagcc tctgctggtc tggggggata ccctccttgt cctggatctt     2520

agccttgacg ttgtcgatgg tgtcggagct ctcgacttct agggttatag tcttgccggt     2580

gagggtctta acgaagatct gcatgccacc acggagacgg aggacgaggt gaagggttga     2640

ttccttctgg atgttgtagt cggcgagggt gcgcccgtcc tcaagttgct ttccggcgaa     2700

gatgagacgt tgctggtctg gggggattcc ctccttgtcc tggatcttgg ccttgacgtt     2760

gtcaatggtg tcagagcttt cgacctctag ggttatggtt ttgccagtga gagtcttgac     2820

gaagatctgc atgccaccac ggagacgaag gacaaggtga agggttgact ccttctggat     2880

gttgtagtcg gcgagggtac ggccgtcctc gagctgcttt ccggcgaaga tgagacgttg     2940

ctgatccggg ggaattcctt ccttgtcctg gatcttggcc ttgacgttgt cgatggtgtc     3000

agagctttcc acctcaaggg tgatggtctt tccggtgagg gtcttgacga agatctgcat     3060

ctgtagagtc aacaatcaca agataaatca gaatcaaaat ccatcacgta atttcaagaa     3120

gcaatttcgt gaaaaaaaat cctaa                                           3145


<210>  106
<211>  3149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha HDR template with aadA insertion

<400>  106
ttggtgtgaa acagatgatt tgctgctgta acaaagtaaa ttatgtctcg acttttaagg       60

cccctttcat tttattagat tattttattt taattaatgt tcttgtccca ttttgcaaca      120

gatggatgct actacaccca agtattccaa ggccaggtat gatgaaattg tgaaggaagt      180

ctcttcctac ttgaagaaag taggatacaa ccctgacaag attccttttg ttcctatctc      240

tggttttgag ggagacaaca tgattgagag gtccacaaac cttgactggt acaagggtcc      300

aactctgctt gatgcacttg accagattag tgagcccaag aggccctctg acaagcccct      360

caggcttccc cttcaggatg tgtacaagat tggaggtatt ggaactgtgc cagtgggacg      420

tgttgagacc ggtgtcttga agcctggaat ggtggtgact tttgcaccaa ctggactgac      480

aactgaagtc aagtctgtgg agatgcacca tgaatctctt acagaggcac atcctggtga      540

caatgtggga ttcaatgtta agaatgttgc tgttaaggat ttgaagcgtg gttatgttgc      600

ctcaaactca aaggatgacc ctgcaaagga ggctgctaac ttcacagccc aagtcatcat      660

catgaaccac cctggtcaga ttggaaatgg ctatgcccct gtcctcgact gccacacttc      720

tcacattgct gtcaagtttg ctgaactcat gaccaagatt gacaggcgat ccggcaaaga      780

gcttgagaag gagcccaagt ttttgaagaa cggtgatgct ggttttgtta agatgattcc      840

aaccaaaccc atggttgttg aaactttctc cgagtatcct ccacttggta ggtttgctgt      900

tagggacatg cgtcaaactg ttgctgtggg agtcatcaag aacgttgaga agaaggatcc      960

taccggagcc aaggtcacca aggctgccca gaagaagaag tcaaatgctg ctgatgaagt     1020

ggcaactcaa ttactgaatt ttgacctctt gaagcttgcc ggtgatgttg agtctaaccc     1080

tggaccaatg gcgcaagtta gcagaatctg caatggtgtg cagaacccat ctcttatctc     1140

caatctctcg aaatccagtc aacgcaaatc tcccttatcg gtttctctga agacgcagca     1200

gcatccacga gcttatccga tttcgtcgtc gtggggattg aagaagagtg ggatgacgtt     1260

aattggctct gagcttcgtc ctcttaaggt catgtcttct gtttccacgg cgtgcatggg     1320

ggaagcggtg atcgccgaag tatcgactca actatcagag gtagttggcg tcatcgagcg     1380

ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc tccgcagtgg atggcggcct     1440

gaagccacac agtgatattg atttgctggt tacggtgacc gtaaggcttg atgaaacaac     1500

gcggcgagct ttgatcaacg accttttgga aacttcggct tcccctggag agagcgagat     1560

tctccgcgct gtagaagtca ccattgttgt gcacgacgac atcattccgt ggcgttatcc     1620

agctaagcgc gaactgcaat ttggagaatg gcagcgcaat gacattcttg caggtatctt     1680

cgagccagcc acgatcgaca ttgatctggc tatcttgctg acaaaagcaa gagaacatag     1740

cgttgccttg gtaggtccag cggcggagga actctttgat ccggttcctg aacaggatct     1800

atttgaggcg ctaaatgaaa ccttaacgct atggaactcg ccgcccgact gggctggcga     1860

tgagcgaaat gtagtgctta cgttgtcccg catttggtac agcgcagtaa ccggcaaaat     1920

cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc ctgccggccc agtatcagcc     1980

cgtcatactt gaagctagac aggcttatct tggacaagaa gaagatcgct tggcctcgcg     2040

cgcagatcag ttggaagaat ttgtccacta cgtgaaaggc gagatcacca aggtagtcgg     2100

caaatgaatc gtgcgggctg gttcatcagg gaatgttggc tacaatcaat gttggtttct     2160

tttctgtact cttgtgtctt cttttctagg tagcttgttt ttcggacaaa gtttgaagtc     2220

tccaccatca tctcgcaact gttgttccca gaactgggtt cttgatcgac ggtggcaaaa     2280

ttgcttttat ttatctgtgt tttaatgtgt tgtgtttgtc ggaacccctg attacatttt     2340

tgttaagcgc agcgagtttc aggactttgc tgcgttgtgt tgctttggtt tattaaatgt     2400

caactttcta tttgtagtgt tcaatttttg gcttggtttg ctttttcttt ataatttgtg     2460

ttcaaatttt ggcttggttt gcttttacta taatttgtgt tcaaattttg ggttggattt     2520

tttaacgatc ggctgtttgc tcttcttcct ctgttttgat gtgttcgtga ctatgcaaga     2580

atcttcaatt ttgctaaaat aaacttgctt tgacaacata gaatcaaatc cgagtgcttt     2640

aatattcggt ggtttgtttt tatttttggt tttatgaaag ttaaaatttt aaaagtaaat     2700

cgataaggta taattgtggt ttttatttat cgagaatttt ttaagtgaat cgatataatt     2760

tatttcccct aaaataaaat accaaagaat cgaattcgaa ctttgtcttt aataaaacta     2820

ctaatttaat cattatttgt tctgtgtaag catgagaaat aaattctact tatcttttag     2880

tttaaaacca aaacaggtta agaataattt ttctaaggcc gttatcaagg tcaccaaaaa     2940

tctattcgat ctgaccatat attttcgata cttgtacgat tcgcagatgt tgattggaaa     3000

ttgcaatgaa taaattacaa atgccaaatc cgattatgca atgaatgaat tacaagtgca     3060

tttatccgtt ttgaatctgt tcatgtctac caatgggaga gatttttttc ctgcatctgc     3120

catacatatg ggaagaccga aaatacttt                                       3149


<210>  107
<211>  3149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EF1alpha HDR template with aadA insertion

<400>  107
aaagtatttt cggtcttccc atatgtatgg cagatgcagg aaaaaaatct ctcccattgg       60

tagacatgaa cagattcaaa acggataaat gcacttgtaa ttcattcatt gcataatcgg      120

atttggcatt tgtaatttat tcattgcaat ttccaatcaa catctgcgaa tcgtacaagt      180

atcgaaaata tatggtcaga tcgaatagat ttttggtgac cttgataacg gccttagaaa      240

aattattctt aacctgtttt ggttttaaac taaaagataa gtagaattta tttctcatgc      300

ttacacagaa caaataatga ttaaattagt agttttatta aagacaaagt tcgaattcga      360

ttctttggta ttttatttta ggggaaataa attatatcga ttcacttaaa aaattctcga      420

taaataaaaa ccacaattat accttatcga tttactttta aaattttaac tttcataaaa      480

ccaaaaataa aaacaaacca ccgaatatta aagcactcgg atttgattct atgttgtcaa      540

agcaagttta ttttagcaaa attgaagatt cttgcatagt cacgaacaca tcaaaacaga      600

ggaagaagag caaacagccg atcgttaaaa aatccaaccc aaaatttgaa cacaaattat      660

agtaaaagca aaccaagcca aaatttgaac acaaattata aagaaaaagc aaaccaagcc      720

aaaaattgaa cactacaaat agaaagttga catttaataa accaaagcaa cacaacgcag      780

caaagtcctg aaactcgctg cgcttaacaa aaatgtaatc aggggttccg acaaacacaa      840

cacattaaaa cacagataaa taaaagcaat tttgccaccg tcgatcaaga acccagttct      900

gggaacaaca gttgcgagat gatggtggag acttcaaact ttgtccgaaa aacaagctac      960

ctagaaaaga agacacaaga gtacagaaaa gaaaccaaca ttgattgtag ccaacattcc     1020

ctgatgaacc agcccgcacg attcatttgc cgactacctt ggtgatctcg cctttcacgt     1080

agtggacaaa ttcttccaac tgatctgcgc gcgaggccaa gcgatcttct tcttgtccaa     1140

gataagcctg tctagcttca agtatgacgg gctgatactg ggccggcagg cgctccattg     1200

cccagtcggc agcgacatcc ttcggcgcga ttttgccggt tactgcgctg taccaaatgc     1260

gggacaacgt aagcactaca tttcgctcat cgccagccca gtcgggcggc gagttccata     1320

gcgttaaggt ttcatttagc gcctcaaata gatcctgttc aggaaccgga tcaaagagtt     1380

cctccgccgc tggacctacc aaggcaacgc tatgttctct tgcttttgtc agcaagatag     1440

ccagatcaat gtcgatcgtg gctggctcga agatacctgc aagaatgtca ttgcgctgcc     1500

attctccaaa ttgcagttcg cgcttagctg gataacgcca cggaatgatg tcgtcgtgca     1560

caacaatggt gacttctaca gcgcggagaa tctcgctctc tccaggggaa gccgaagttt     1620

ccaaaaggtc gttgatcaaa gctcgccgcg ttgtttcatc aagccttacg gtcaccgtaa     1680

ccagcaaatc aatatcactg tgtggcttca ggccgccatc cactgcggag ccgtacaaat     1740

gtacggccag caacgtcggt tcgagatggc gctcgatgac gccaactacc tctgatagtt     1800

gagtcgatac ttcggcgatc accgcttccc ccatgcacgc cgtggaaaca gaagacatga     1860

ccttaagagg acgaagctca gagccaatta acgtcatccc actcttcttc aatccccacg     1920

acgacgaaat cggataagct cgtggatgct gctgcgtctt cagagaaacc gataagggag     1980

atttgcgttg actggatttc gagagattgg agataagaga tgggttctgc acaccattgc     2040

agattctgct aacttgcgcc attggtccag ggttagactc aacatcaccg gcaagcttca     2100

agaggtcaaa attcagtaat tgagttgcca cttcatcagc agcatttgac ttcttcttct     2160

gggcagcctt ggtgaccttg gctccggtag gatccttctt ctcaacgttc ttgatgactc     2220

ccacagcaac agtttgacgc atgtccctaa cagcaaacct accaagtgga ggatactcgg     2280

agaaagtttc aacaaccatg ggtttggttg gaatcatctt aacaaaacca gcatcaccgt     2340

tcttcaaaaa cttgggctcc ttctcaagct ctttgccgga tcgcctgtca atcttggtca     2400

tgagttcagc aaacttgaca gcaatgtgag aagtgtggca gtcgaggaca ggggcatagc     2460

catttccaat ctgaccaggg tggttcatga tgatgacttg ggctgtgaag ttagcagcct     2520

cctttgcagg gtcatccttt gagtttgagg caacataacc acgcttcaaa tccttaacag     2580

caacattctt aacattgaat cccacattgt caccaggatg tgcctctgta agagattcat     2640

ggtgcatctc cacagacttg acttcagttg tcagtccagt tggtgcaaaa gtcaccacca     2700

ttccaggctt caagacaccg gtctcaacac gtcccactgg cacagttcca atacctccaa     2760

tcttgtacac atcctgaagg ggaagcctga ggggcttgtc agagggcctc ttgggctcac     2820

taatctggtc aagtgcatca agcagagttg gacccttgta ccagtcaagg tttgtggacc     2880

tctcaatcat gttgtctccc tcaaaaccag agataggaac aaaaggaatc ttgtcagggt     2940

tgtatcctac tttcttcaag taggaagaga cttccttcac aatttcatca tacctggcct     3000

tggaatactt gggtgtagta gcatccatct gttgcaaaat gggacaagaa cattaattaa     3060

aataaaataa tctaataaaa tgaaaggggc cttaaaagtc gagacataat ttactttgtt     3120

acagcagcaa atcatctgtt tcacaccaa                                       3149


<210>  108
<211>  3145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin HDR template with aadA insertion

<400>  108
ttaggatttt ttttcacgaa attgcttctt gaaattacgt gatggatttt gattctgatt       60

tatcttgtga ttgttgactc tacagatgca gatcttcgtc aagaccctca ccggaaagac      120

catcaccctt gaggtggaaa gctctgacac catcgacaac gtcaaggcca agatccagga      180

caaggaagga attcccccgg atcagcaacg tctcatcttc gccggaaagc agctcgagga      240

cggccgtacc ctcgccgact acaacatcca gaaggagtca acccttcacc ttgtccttcg      300

tctccgtggt ggcatgcaga tcttcgtcaa gactctcact ggcaaaacca taaccctaga      360

ggtcgaaagc tctgacacca ttgacaacgt caaggccaag atccaggaca aggagggaat      420

ccccccagac cagcaacgtc tcatcttcgc cggaaagcaa cttgaggacg ggcgcaccct      480

cgccgactac aacatccaga aggaatcaac ccttcacctc gtcctccgtc tccgtggtgg      540

catgcagatc ttcgttaaga ccctcaccgg caagactata accctagaag tcgagagctc      600

cgacaccatc gacaacgtca aggctaagat ccaggacaag gagggtatcc ccccagacca      660

gcagaggctg atcttcgccg gcaagcagct cgaggacgga cgtacccttg ctgactacaa      720

catccagaag gagtcaactc tccacttggt gttgcgtctt cgtggtggta tgcagatctt      780

cgtcaagacc cttacgggta agactattac cctcgaggtg gagagctccg acaccattga      840

caatgtgaag gcgaagatcc aggacaagga aggaatccca ccggaccagc agaggcttat      900

ttttgctggc aaacagctag aggatggaag gaccctcgct gactacaaca tccagaagga      960

gtcaactctg cacttggtgt tgcgtcttcg tggggggttt tcaaatgctg ctgatgaagt     1020

ggcaactcaa ttactgaatt ttgacctctt gaagcttgcc ggtgatgttg agtctaaccc     1080

tggaccaatg gcgcaagtta gcagaatctg caatggtgtg cagaacccat ctcttatctc     1140

caatctctcg aaatccagtc aacgcaaatc tcccttatcg gtttctctga agacgcagca     1200

gcatccacga gcttatccga tttcgtcgtc gtggggattg aagaagagtg ggatgacgtt     1260

aattggctct gagcttcgtc ctcttaaggt catgtcttct gtttccacgg cgtgcatggg     1320

ggaagcggtg atcgccgaag tatcgactca actatcagag gtagttggcg tcatcgagcg     1380

ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc tccgcagtgg atggcggcct     1440

gaagccacac agtgatattg atttgctggt tacggtgacc gtaaggcttg atgaaacaac     1500

gcggcgagct ttgatcaacg accttttgga aacttcggct tcccctggag agagcgagat     1560

tctccgcgct gtagaagtca ccattgttgt gcacgacgac atcattccgt ggcgttatcc     1620

agctaagcgc gaactgcaat ttggagaatg gcagcgcaat gacattcttg caggtatctt     1680

cgagccagcc acgatcgaca ttgatctggc tatcttgctg acaaaagcaa gagaacatag     1740

cgttgccttg gtaggtccag cggcggagga actctttgat ccggttcctg aacaggatct     1800

atttgaggcg ctaaatgaaa ccttaacgct atggaactcg ccgcccgact gggctggcga     1860

tgagcgaaat gtagtgctta cgttgtcccg catttggtac agcgcagtaa ccggcaaaat     1920

cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc ctgccggccc agtatcagcc     1980

cgtcatactt gaagctagac aggcttatct tggacaagaa gaagatcgct tggcctcgcg     2040

cgcagatcag ttggaagaat ttgtccacta cgtgaaaggc gagatcacca aggtagtcgg     2100

caaataagct ggagctgatg tctgtgtgat gtctgatgtt ggattttccc agacatttta     2160

agaagaaatg tgatgtgtaa tgggtctgta atgacctttg aaaataagtt tggtttgtgt     2220

tgaactctat tgtcccatta atgttactac tgtttgttat caatttgtgg agctgatata     2280

taattatcaa ctgtatgctg gcatattgtg tttgaatttt gttctcaatc cagtgaattg     2340

gcgtatatta gtgggttttt tattcttcat gcttatcacg gaggaaaagc agggatgagt     2400

tgtgtgaagg atggtgatca tcccacgaat tattagattt tggtattata ggttaaagat     2460

atttattagg tagggagaac tcttggatta gattctaaag tgatattttg aaaacacacc     2520

aaaggatttt tgaacaaacg gagatcatga tccctagttt caattagctg ccccttacca     2580

agaggtagca acttaaaaat tatgctcgtg aagcatattt ggtatcgtat ataaattatg     2640

taagcaatct gcttcagttg gaacattaat tggcttgcgg aatgcacatt tagatgatcc     2700

acacaggtcc acataaaaat tcctaatcaa ttttagttat gcaatctttc tgcttcaggt     2760

agtccttgtc ttacagaaag cacattgaga tgatccccac acagatccac ataaaaaatt     2820

cctaatcaat aataacttga aaatcattaa aagatgtaat gccatactaa tccctaattt     2880

ttgtgcaagt ttttgtatac tggaccccaa aaaataccaa aaagaaaaaa caagttattc     2940

agtgatattt ttctgctcca atataaattt gattaccaaa taccaaaaaa taaaaacact     3000

attcagtggt atttttctgc tccaatactg gaccccaaat taatcagaat cggatccgtt     3060

taacagataa aaacaaaagc gatcgggtta aaatcccatt tttacaaata acaacgcagg     3120

tttatacatg aaacaaatgt catta                                           3145


<210>  109
<211>  3145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin HDR template with aadA insertion

<400>  109
taatgacatt tgtttcatgt ataaacctgc gttgttattt gtaaaaatgg gattttaacc       60

cgatcgcttt tgtttttatc tgttaaacgg atccgattct gattaatttg gggtccagta      120

ttggagcaga aaaataccac tgaatagtgt ttttattttt tggtatttgg taatcaaatt      180

tatattggag cagaaaaata tcactgaata acttgttttt tctttttggt attttttggg      240

gtccagtata caaaaacttg cacaaaaatt agggattagt atggcattac atcttttaat      300

gattttcaag ttattattga ttaggaattt tttatgtgga tctgtgtggg gatcatctca      360

atgtgctttc tgtaagacaa ggactacctg aagcagaaag attgcataac taaaattgat      420

taggaatttt tatgtggacc tgtgtggatc atctaaatgt gcattccgca agccaattaa      480

tgttccaact gaagcagatt gcttacataa tttatatacg ataccaaata tgcttcacga      540

gcataatttt taagttgcta cctcttggta aggggcagct aattgaaact agggatcatg      600

atctccgttt gttcaaaaat cctttggtgt gttttcaaaa tatcacttta gaatctaatc      660

caagagttct ccctacctaa taaatatctt taacctataa taccaaaatc taataattcg      720

tgggatgatc accatccttc acacaactca tccctgcttt tcctccgtga taagcatgaa      780

gaataaaaaa cccactaata tacgccaatt cactggattg agaacaaaat tcaaacacaa      840

tatgccagca tacagttgat aattatatat cagctccaca aattgataac aaacagtagt      900

aacattaatg ggacaataga gttcaacaca aaccaaactt attttcaaag gtcattacag      960

acccattaca catcacattt cttcttaaaa tgtctgggaa aatccaacat cagacatcac     1020

acagacatca gctccagctt atttgccgac taccttggtg atctcgcctt tcacgtagtg     1080

gacaaattct tccaactgat ctgcgcgcga ggccaagcga tcttcttctt gtccaagata     1140

agcctgtcta gcttcaagta tgacgggctg atactgggcc ggcaggcgct ccattgccca     1200

gtcggcagcg acatccttcg gcgcgatttt gccggttact gcgctgtacc aaatgcggga     1260

caacgtaagc actacatttc gctcatcgcc agcccagtcg ggcggcgagt tccatagcgt     1320

taaggtttca tttagcgcct caaatagatc ctgttcagga accggatcaa agagttcctc     1380

cgccgctgga cctaccaagg caacgctatg ttctcttgct tttgtcagca agatagccag     1440

atcaatgtcg atcgtggctg gctcgaagat acctgcaaga atgtcattgc gctgccattc     1500

tccaaattgc agttcgcgct tagctggata acgccacgga atgatgtcgt cgtgcacaac     1560

aatggtgact tctacagcgc ggagaatctc gctctctcca ggggaagccg aagtttccaa     1620

aaggtcgttg atcaaagctc gccgcgttgt ttcatcaagc cttacggtca ccgtaaccag     1680

caaatcaata tcactgtgtg gcttcaggcc gccatccact gcggagccgt acaaatgtac     1740

ggccagcaac gtcggttcga gatggcgctc gatgacgcca actacctctg atagttgagt     1800

cgatacttcg gcgatcaccg cttcccccat gcacgccgtg gaaacagaag acatgacctt     1860

aagaggacga agctcagagc caattaacgt catcccactc ttcttcaatc cccacgacga     1920

cgaaatcgga taagctcgtg gatgctgctg cgtcttcaga gaaaccgata agggagattt     1980

gcgttgactg gatttcgaga gattggagat aagagatggg ttctgcacac cattgcagat     2040

tctgctaact tgcgccattg gtccagggtt agactcaaca tcaccggcaa gcttcaagag     2100

gtcaaaattc agtaattgag ttgccacttc atcagcagca tttgaaaacc ccccacgaag     2160

acgcaacacc aagtgcagag ttgactcctt ctggatgttg tagtcagcga gggtccttcc     2220

atcctctagc tgtttgccag caaaaataag cctctgctgg tccggtggga ttccttcctt     2280

gtcctggatc ttcgccttca cattgtcaat ggtgtcggag ctctccacct cgagggtaat     2340

agtcttaccc gtaagggtct tgacgaagat ctgcatacca ccacgaagac gcaacaccaa     2400

gtggagagtt gactccttct ggatgttgta gtcagcaagg gtacgtccgt cctcgagctg     2460

cttgccggcg aagatcagcc tctgctggtc tggggggata ccctccttgt cctggatctt     2520

agccttgacg ttgtcgatgg tgtcggagct ctcgacttct agggttatag tcttgccggt     2580

gagggtctta acgaagatct gcatgccacc acggagacgg aggacgaggt gaagggttga     2640

ttccttctgg atgttgtagt cggcgagggt gcgcccgtcc tcaagttgct ttccggcgaa     2700

gatgagacgt tgctggtctg gggggattcc ctccttgtcc tggatcttgg ccttgacgtt     2760

gtcaatggtg tcagagcttt cgacctctag ggttatggtt ttgccagtga gagtcttgac     2820

gaagatctgc atgccaccac ggagacgaag gacaaggtga agggttgact ccttctggat     2880

gttgtagtcg gcgagggtac ggccgtcctc gagctgcttt ccggcgaaga tgagacgttg     2940

ctgatccggg ggaattcctt ccttgtcctg gatcttggcc ttgacgttgt cgatggtgtc     3000

agagctttcc acctcaaggg tgatggtctt tccggtgagg gtcttgacga agatctgcat     3060

ctgtagagtc aacaatcaca agataaatca gaatcaaaat ccatcacgta atttcaagaa     3120

gcaatttcgt gaaaaaaaat cctaa                                           3145


<210>  110
<211>  505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ost1 HDR template - antisense orientation

<400>  110
aaaagattga cacattgcct atactacatt ctagcgtagg ttaaatttat atcagataat       60

gtgggagaaa gagatcagtt accattgcat gacaatagct gaccccagat atgagttgtt      120

gaaagaagaa acgagcctgt ggcatgacaa tgggttaata gttacacagg aaatagagag      180

ctagcacaag caaaagtaaa caaattgtat aagaacctca tcctcattaa aacgccctgc      240

attgcagatt ttctcaaata gttctccacc agatgcatat tccattacaa tgtctagatg      300

agtcggtgtt agaataacct gagtcaaata tcaaagaaca ttttccatga atatgattat      360

tgtacctctg aacataaaaa tatataaata caaatatata ccaacctcct taaacctgat      420

aatgttagga tgtcttagag acctgtgatt aatgatttct cttttaacat tttcatcaat      480

ctgtgacaca cagcaaatga taggg                                            505


<210>  111
<211>  3145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin HDR template with aadA insertion

<400>  111
ttaggatttt ttttcacgaa attgcttctt gaaattacgt gatggatttt gattctgatt       60

tatcttgtga ttgttgactc tacagatgca gatcttcgtc aagaccctca ccggaaagac      120

catcaccctt gaggtggaaa gctctgacac catcgacaac gtcaaggcca agatccagga      180

caaggaagga attcccccgg atcagcaacg tctcatcttc gccggaaagc agctcgagga      240

cggccgtacc ctcgccgact acaacatcca gaaggagtca acccttcacc ttgtccttcg      300

tctccgtggt ggcatgcaga tcttcgtcaa gactctcact ggcaaaacca taaccctaga      360

ggtcgaaagc tctgacacca ttgacaacgt caaggccaag atccaggaca aggagggaat      420

ccccccagac cagcaacgtc tcatcttcgc cggaaagcaa cttgaggacg ggcgcaccct      480

cgccgactac aacatccaga aggaatcaac ccttcacctc gtcctccgtc tccgtggtgg      540

catgcagatc ttcgttaaga ccctcaccgg caagactata accctagaag tcgagagctc      600

cgacaccatc gacaacgtca aggctaagat ccaggacaag gagggtatcc ccccagacca      660

gcagaggctg atcttcgccg gcaagcagct cgaggacgga cgtacccttg ctgactacaa      720

catccagaag gagtcaactc tccacttggt gttgcgtctt cgtggtggta tgcagatctt      780

cgtcaagacc cttacgggta agactattac cctcgaggtg gagagctccg acaccattga      840

caatgtgaag gcgaagatcc aggacaagga aggaatccca ccggaccagc agaggcttat      900

ttttgctggc aaacagctag aggatggaag gaccctcgct gactacaaca tccagaagga      960

gtcaactctg cacttggtgt tgcgtcttcg tggggggttt tcaaatgctg ctgatgaagt     1020

ggcaactcaa ttactgaatt ttgacctctt gaagcttgcc ggtgatgttg agtctaaccc     1080

tggaccaatg gcgcaagtta gcagaatctg caatggtgtg cagaacccat ctcttatctc     1140

caatctctcg aaatccagtc aacgcaaatc tcccttatcg gtttctctga agacgcagca     1200

gcatccacga gcttatccga tttcgtcgtc gtggggattg aagaagagtg ggatgacgtt     1260

aattggctct gagcttcgtc ctcttaaggt catgtcttct gtttccacgg cgtgcatggg     1320

ggaagcggtg atcgccgaag tatcgactca actatcagag gtagttggcg tcatcgagcg     1380

ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc tccgcagtgg atggcggcct     1440

gaagccacac agtgatattg atttgctggt tacggtgacc gtaaggcttg atgaaacaac     1500

gcggcgagct ttgatcaacg accttttgga aacttcggct tcccctggag agagcgagat     1560

tctccgcgct gtagaagtca ccattgttgt gcacgacgac atcattccgt ggcgttatcc     1620

agctaagcgc gaactgcaat ttggagaatg gcagcgcaat gacattcttg caggtatctt     1680

cgagccagcc acgatcgaca ttgatctggc tatcttgctg acaaaagcaa gagaacatag     1740

cgttgccttg gtaggtccag cggcggagga actctttgat ccggttcctg aacaggatct     1800

atttgaggcg ctaaatgaaa ccttaacgct atggaactcg ccgcccgact gggctggcga     1860

tgagcgaaat gtagtgctta cgttgtcccg catttggtac agcgcagtaa ccggcaaaat     1920

cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc ctgccggccc agtatcagcc     1980

cgtcatactt gaagctagac aggcttatct tggacaagaa gaagatcgct tggcctcgcg     2040

cgcagatcag ttggaagaat ttgtccacta cgtgaaaggc gagatcacca aggtagtcgg     2100

caaataagct ggagctgatg tctgtgtgat gtctgatgtt ggattttccc agacatttta     2160

agaagaaatg tgatgtgtaa tgggtctgta atgacctttg aaaataagtt tggtttgtgt     2220

tgaactctat tgtcccatta atgttactac tgtttgttat caatttgtgg agctgatata     2280

taattatcaa ctgtatgctg gcatattgtg tttgaatttt gttctcaatc cagtgaattg     2340

gcgtatatta gtgggttttt tattcttcat gcttatcacg gaggaaaagc agggatgagt     2400

tgtgtgaagg atggtgatca tcccacgaat tattagattt tggtattata ggttaaagat     2460

atttattagg tagggagaac tcttggatta gattctaaag tgatattttg aaaacacacc     2520

aaaggatttt tgaacaaacg gagatcatga tccctagttt caattagctg ccccttacca     2580

agaggtagca acttaaaaat tatgctcgtg aagcatattt ggtatcgtat ataaattatg     2640

taagcaatct gcttcagttg gaacattaat tggcttgcgg aatgcacatt tagatgatcc     2700

acacaggtcc acataaaaat tcctaatcaa ttttagttat gcaatctttc tgcttcaggt     2760

agtccttgtc ttacagaaag cacattgaga tgatccccac acagatccac ataaaaaatt     2820

cctaatcaat aataacttga aaatcattaa aagatgtaat gccatactaa tccctaattt     2880

ttgtgcaagt ttttgtatac tggaccccaa aaaataccaa aaagaaaaaa caagttattc     2940

agtgatattt ttctgctcca atataaattt gattaccaaa taccaaaaaa taaaaacact     3000

attcagtggt atttttctgc tccaatactg gaccccaaat taatcagaat cggatccgtt     3060

taacagataa aaacaaaagc gatcgggtta aaatcccatt tttacaaata acaacgcagg     3120

tttatacatg aaacaaatgt catta                                           3145


<210>  112
<211>  5382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin Locus with aadA insertion

<400>  112
tttcatcgat tataaatttt cataatcaga agattcagct tttattaatg caagaacgtc       60

cttaattgat gattttataa ccgtaaatta ggtctaatta gagttttttt cataaagatt      120

ttcagatccg tttacaacaa gccttaattg ttgattctgt agtcgtagat taaggttttt      180

ttcatgaact acttcagatc cgttaaacaa cagccttatt tgttgatact tcagtcgttt      240

ttcaagaaat tgttcagatc cgttgataaa agccttattc gttgattctg tatggtattt      300

caagagatat tgctcaggtc ctttagcaac taccttattt gttgattctg tggccataga      360

ttaggatttt ttttcacgaa attgcttctt gaaattacgt gatggatttt gattctgatt      420

tatcttgtga ttgttgactc tacagatgca gatcttcgtc aagaccctca ccggaaagac      480

catcaccctt gaggtggaaa gctctgacac catcgacaac gtcaaggcca agatccagga      540

caaggaagga attcccccgg atcagcaacg tctcatcttc gccggaaagc agctcgagga      600

cggccgtacc ctcgccgact acaacatcca gaaggagtca acccttcacc ttgtccttcg      660

tctccgtggt ggcatgcaga tcttcgtcaa gactctcact ggcaaaacca taaccctaga      720

ggtcgaaagc tctgacacca ttgacaacgt caaggccaag atccaggaca aggagggaat      780

ccccccagac cagcaacgtc tcatcttcgc cggaaagcaa cttgaggacg ggcgcaccct      840

cgccgactac aacatccaga aggaatcaac ccttcacctc gtcctccgtc tccgtggtgg      900

catgcagatc ttcgttaaga ccctcaccgg caagactata accctagaag tcgagagctc      960

cgacaccatc gacaacgtca aggctaagat ccaggacaag gagggtatcc ccccagacca     1020

gcagaggctg atcttcgccg gcaagcagct cgaggacgga cgtacccttg ctgactacaa     1080

catccagaag gagtcaactc tccacttggt gttgcgtctt cgtggtggta tgcagatctt     1140

cgtcaagacc cttacgggta agactattac cctcgaggtg gagagctccg acaccattga     1200

caatgtgaag gcgaagatcc aggacaagga aggaatccca ccggaccagc agaggcttat     1260

ttttgctggc aaacagctag aggatggaag gaccctcgct gactacaaca tccagaagga     1320

gtcaactctg cacttggtgt tgcgtcttcg tggggggttt tcaaatgctg ctgatgaagt     1380

ggcaactcaa ttactgaatt ttgacctctt gaagcttgcc ggtgatgttg agtctaaccc     1440

tggaccaatg gcgcaagtta gcagaatctg caatggtgtg cagaacccat ctcttatctc     1500

caatctctcg aaatccagtc aacgcaaatc tcccttatcg gtttctctga agacgcagca     1560

gcatccacga gcttatccga tttcgtcgtc gtggggattg aagaagagtg ggatgacgtt     1620

aattggctct gagcttcgtc ctcttaaggt catgtcttct gtttccacgg cgtgcatggg     1680

ggaagcggtg atcgccgaag tatcgactca actatcagag gtagttggcg tcatcgagcg     1740

ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc tccgcagtgg atggcggcct     1800

gaagccacac agtgatattg atttgctggt tacggtgacc gtaaggcttg atgaaacaac     1860

gcggcgagct ttgatcaacg accttttgga aacttcggct tcccctggag agagcgagat     1920

tctccgcgct gtagaagtca ccattgttgt gcacgacgac atcattccgt ggcgttatcc     1980

agctaagcgc gaactgcaat ttggagaatg gcagcgcaat gacattcttg caggtatctt     2040

cgagccagcc acgatcgaca ttgatctggc tatcttgctg acaaaagcaa gagaacatag     2100

cgttgccttg gtaggtccag cggcggagga actctttgat ccggttcctg aacaggatct     2160

atttgaggcg ctaaatgaaa ccttaacgct atggaactcg ccgcccgact gggctggcga     2220

tgagcgaaat gtagtgctta cgttgtcccg catttggtac agcgcagtaa ccggcaaaat     2280

cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc ctgccggccc agtatcagcc     2340

cgtcatactt gaagctagac aggcttatct tggacaagaa gaagatcgct tggcctcgcg     2400

cgcagatcag ttggaagaat ttgtccacta cgtgaaaggc gagatcacca aggtagtcgg     2460

caaataagct ggagctgatg tctgtgtgat gtctgatgtt ggattttccc agacatttta     2520

agaagaaatg tgatgtgtaa tgggtctgta atgacctttg aaaataagtt tggtttgtgt     2580

tgaactctat tgtcccatta atgttactac tgtttgttat caatttgtgg agctgatata     2640

taattatcaa ctgtatgctg gcatattgtg tttgaatttt gttctcaatc cagtgaattg     2700

gcgtatatta gtgggttttt tattcttcat gcttatcacg gaggaaaagc agggatgagt     2760

tgtgtgaagg atggtgatca tcccacgaat tattagattt tggtattata ggttaaagat     2820

atttattagg tagggagaac tcttggatta gattctaaag tgatattttg aaaacacacc     2880

aaaggatttt tgaacaaacg gagatcatga tccctagttt caattagctg ccccttacca     2940

agaggtagca acttaaaaat tatgctcgtg aagcatattt ggtatcgtat ataaattatg     3000

taagcaatct gcttcagttg gaacattaat tggcttgcgg aatgcacatt tagatgatcc     3060

acacaggtcc acataaaaat tcctaatcaa ttttagttat gcaatctttc tgcttcaggt     3120

agtccttgtc ttacagaaag cacattgaga tgatccccac acagatccac ataaaaaatt     3180

cctaatcaat aataacttga aaatcattaa aagatgtaat gccatactaa tccctaattt     3240

ttgtgcaagt ttttgtatac tggaccccaa aaaataccaa aaagaaaaaa caagttattc     3300

agtgatattt ttctgctcca atataaattt gattaccaaa taccaaaaaa taaaaacact     3360

attcagtggt atttttctgc tccaatactg gaccccaaat taatcagaat cggatccgtt     3420

taacagataa aaacaaaagc gatcgggtta aaatcccatt tttacaaata acaacgcagg     3480

tttatacatg aaacaaatgt cattaccaag tgatattttt ctgctccgat ataaatttga     3540

ttacaacgaa aaaaagtggt ctactcacat gtttctccat tttacttgtg tataaaactc     3600

atttcaagtt gtatctgatt cgtcgaaaaa acaaaacaga atagtaatac tctataccct     3660

ttttatcatc attaattttg taattatatg gattaataaa aggttcctcc cagagttaaa     3720

ttgttgtgtt ggcgtgcgtg tagagcttct cttccaacaa gagacaagct tgagatcgtg     3780

gagtaacctg tcccttaacg tgctctttgt tctctttgtg cgagggtggc attgaaaata     3840

catttcacgt gcttacagtt tgcccgagga tcatggaatg ctggcagaag ttggggttga     3900

gcagcagaag ttgatagaat tcttcttcaa actcatgctt tctattgaat cttatcaaca     3960

atgtagagta gctataactc tctggagagt gcttggagat gtcactatga tgctgtttga     4020

ggagggacta tcacggattc cgccatcgtg atcagcagag atgacatgtt ttatcaagat     4080

tgggttcgtg cacaactagc aaataaattt agacaggttg cagaattgat ggagatgaat     4140

gattcttgga gtccaccggc cattggaagg ttaaaatgta acgttgatgc atctctcaat     4200

catattcaaa actgcacagt ttttggttta tgcattcggg catcttattg ttgccagaat     4260

tgatgttgtg aaaccatgca tgcctgttat ggagggagag gcgttagggt tgctgttggc     4320

gattcagttt tttctatatg cgggaatgca aaatgtggac tttgaaacag attgtaaagg     4380

gtgtgttgat agaaaaataa aataaaatac ccacccttga tattagcaga ggaaatattt     4440

tctgtaaatg taaaattttg ttacaacccg ctcttttatt ttcttttata gagcaattct     4500

ctacacttgt ctaagaatct ataatactta cattactaat cttactaaca caagcttctt     4560

gtaggtatgt ctggatggag aattttagaa gaaaagtgat ttttttttaa ttttttaatt     4620

aaaggagttg tacaatgttg tgagaaaaaa actaggaaat attaaatgat ttcatcataa     4680

aacatcgttt tactattttt tttattttgg taaattgctc caataaataa atcttatgta     4740

aaccactttt tagtatatat taaaaaaata ttatttatga gtgctacatt ctctaagagg     4800

aagatggtct attattactt gggagcccat ttcttcagca tacgatgcac aaataagccg     4860

ctagtgctaa ttcaattttg gggttatcta actatccttc cggcgaaact tgatgcagga     4920

aaacgtttgt ttaatacttg acatgaattc aacgaacaac ctctttgagg ggacaatcag     4980

aagcacaaac caagcaccga atcatccaag tttgctatct tacgcaaggc attaggtata     5040

aacctagttt gaataaattt ttcaagtact cgtaggaaat aaatacaggt aaaataaatc     5100

aaacatctat aagatcaatc caacttatag acactttagt ttttctagaa gttagacgaa     5160

aaaacttgta aaaaagacaa aatgctgcac aagttaattt taatttatga ccaaagtttt     5220

attcatttta tcaaccttat tttcttcttc cataaatatt tgttgaaaag cttattcaaa     5280

ttggaccata gagcatgttg gaatgagaat tttagcacgt tactcaatcc aacagcatca     5340

taacaactta atggaaccgg aattttcacg ccatggcata tg                        5382


<210>  113
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin left flank primer

<400>  113
ggtatttcaa gagatattgc tcaggtcctt tagcaactac                             40


<210>  114
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aadA specific primer for left flank PCR

<400>  114
gggttctgca caccattgca gattctg                                           27


<210>  115
<211>  18505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3091 Full Plasmid Sequence

<400>  115
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cgccgccgcc tgccctccct ccaaagaggc gaagaagtgg tggatcttcc ggggggtccc     9780

cccctcctgc tttacctcca aaaagacgtc gttctggtgg ttcaagtgga ggttctccac     9840

ctcctgcact tcctcccaag agaagaagga gcggcggcag ctcaggagga tcaccaccac     9900

cagctttgcc acccaaaagg cgccggggct cctccgagac accaggcacc tccgagagcg     9960

cgacgcccga gggcggctcc ggcggctccg gcagctccaa gctggagaag tttacaaact    10020

gttacagcct ctccaaaacc ctcaggttta aagcgatccc ggtgggcaag acccaggaga    10080

acatcgacaa caagaggctc ctggtggaag acgagaagcg cgccgaagac tacaagggcg    10140

tgaagaagct gctcgatagg tactacctca gctttattaa cgacgtgctg cacagcatca    10200

aactcaagaa tctcaacaac tacatctccc tcttccgcaa aaagacccgc accgagaagg    10260

agaacaagga gctggagaac ctggagatca acctccgcaa ggaaatcgcc aaagcgttca    10320

agggcaatga agggtacaag agcctcttca agaaagacat catcgaaact atcctcccag    10380

agtttctcga tgacaaggac gagatcgcgc tggtgaactc ctttaacggg ttcacaaccg    10440

cgtttaccgg cttctttgat aacagggaaa atatgttctc cgaggaggcc aagtccacca    10500

gcatcgcctt caggtgtatc aacgagaacc tcacccgcta catttccaat atggacattt    10560

tcgagaaggt ggatgcgatc ttcgataagc acgaggtgca ggagatcaaa gagaagattc    10620

tcaattccga ttatgacgtc gaggatttct tcgaagggga gttctttaat tttgtgctca    10680

cacaagaggg cattgacgtg tacaacgcga ttatcggggg cttcgtcaca gagtccgggg    10740

agaagattaa ggggctgaat gagtacatca atctgtacaa tcagaagacc aagcagaaac    10800

tgccgaaatt caagccgctc tacaagcaag tcctgtccga tagggaaagc ctctccttct    10860

acggcgaggg ctataccagc gacgaggagg tgctggaagt cttccgcaac acactgaata    10920

agaatagcga gattttctcc tccatcaaga agctcgagaa gctctttaag aactttgacg    10980

agtacagctc cgccgggatt ttcgtgaaga acgggccggc gatcagcacc atctccaagg    11040

acatctttgg cgagtggaac gtcatcaggg acaagtggaa cgccgagtac gacgacatcc    11100

acctgaagaa gaaggcggtg gtgaccgaga agtatgagga cgatcgcagg aagtccttca    11160

aaaaaatcgg ctccttcagc ctcgaacagc tccaggagta tgccgatgcg gatctgtccg    11220

tcgtcgagaa gctgaaggaa atcatcattc agaaggtcga cgagatctat aaagtgtacg    11280

ggtccagcga gaagctgttc gacgccgact ttgtgctcga gaagtccctc aaaaagaatg    11340

acgccgtggt ggccattatg aaagacctgc tcgactccgt gaagtccttc gaaaattaca    11400

ttaaagcgtt ctttggggag gggaaggaaa ctaacaggga tgagtccttc tatggcgact    11460

ttgtcctcgc gtacgacatc ctgctgaagg tcgaccacat ttacgacgcg atccgcaact    11520

acgtgacaca gaagccgtac tccaaagaca agttcaagct gtacttccag aacccgcaat    11580

ttatgggggg ctgggacaag gataaagaga cagactaccg cgcgacaatt ctccgctatg    11640

gctccaaata ctatctggcc atcatggaca agaagtacgc gaagtgcctg cagaagatcg    11700

acaaagacga cgtcaatggc aactatgaaa agatcaacta caagctgctg ccgggtccga    11760

acaagatgct cccgaaggtg ttcttcagca agaagtggat ggcctactac aatccaagcg    11820

aggatattca gaaaatctat aaaaacggga ccttcaagaa gggggacatg tttaacctca    11880

acgactgcca caagctcatt gatttcttca aggatagcat ttcccgctac ccgaaatggt    11940

ccaatgcgta cgattttaac ttctccgaga cagaaaagta caaagacatc gcgggctttt    12000

acagggaggt ggaggagcaa gggtataaag tttcttttga atccgcgagc aagaaggaag    12060

tcgacaagct cgtcgaggag ggcaagctct acatgttcca aatttataac aaggactttt    12120

ccgacaagag ccatgggacc ccaaacctcc acaccatgta cttcaaactg ctctttgacg    12180

agaacaacca cgggcaaatc aggctgagcg gcggcgccga attattcatg cgcagggcct    12240

ccctcaagaa ggaagagctg gtcgtccatc cagccaattc cccgatcgcg aacaagaacc    12300

cggacaatcc gaaaaagacc accaccctgt cctacgacgt ctacaaggac aaacgcttca    12360

gcgaagacca gtacgaatta cacatcccaa ttgcgattaa taagtgccca aagaatatct    12420

tcaaaattaa tacagaggtc agggtgctgc tcaaacacga cgacaatccg tatgtcatcg    12480

gcattgacag gggcgagcgc aatctgctct atatcgtggt cgtggatggg aagggcaata    12540

ttgtggagca gtactccctg aacgagatta tcaacaactt caatgggatt aggattaaga    12600

ccgactatca cagcctgctc gacaagaaag aaaaagagag gtttgaggcc cgccaaaact    12660

ggacctccat tgagaatatc aaagaattaa aggccggcta tatttcccaa gtcgtccaca    12720

agatctgcga gctggtggag aaatatgacg ccgtgattgc gctcgaagac ttaaattctg    12780

ggttcaagaa ctcccgcgtg aaggtggaaa aacaggtgta tcagaaattc gagaaaatgc    12840

tgatcgacaa actcaattat atggtggata agaagtccaa cccgtgtgcc acagggggcg    12900

cgctgaaggg ctatcagatc accaacaagt tcgagagctt caagagcatg agcacccaga    12960

acgggtttat tttctacatc ccggcgtggc tcacctccaa gattgacccg agcaccggct    13020

tcgtgaacct cctgaagaca aagtatacct ccattgccga cagcaagaag tttatctcct    13080

ccttcgaccg cattatgtat gtgccggagg aggacctctt cgagttcgcc ctcgactaca    13140

aaaacttcag ccgcacagat gcggattaca tcaagaagtg gaagctgtac tcctacggga    13200

acaggatccg catcttcagg aatccaaaaa aaaataacgt ctttgactgg gaggaagtgt    13260

gcctgacatc cgcctacaag gaactgttca ataaatacgg catcaattac cagcagggcg    13320

acattcgcgc cctcctctgt gagcagtccg acaaagcgtt ttactccagc ttcatggccc    13380

tcatgtccct gatgctccaa atgaggaata gcatcacagg gcgcaccgac gtcgacttcc    13440

tcatcagccc ggtgaagaac tccgacggga tcttttacga ctcccgcaac tatgaggcgc    13500

aagagaatgc gatcctcccg aagaacgccg atgcgaacgg ggcctataat atcgccagga    13560

aagtgctctg ggccatcggg cagttcaaaa aggcggagga tgagaagctc gacaaggtga    13620

aaattgccat ttccaacaag gagtggctgg agtacgcgca gacctccgtg aagcactgaa    13680

agggctctct gtcatgattt catactttca ttattgagct ctgtaattac aattatgacc    13740

atgagaacat ctcttattgt gtggcctttt aattgctgat gttagtactg aaccaaagct    13800

tatcgtgatg atgtaaaagc aataagtact tgtttgtagc ttctttgtgt ctccctttgg    13860

gcttaataca tctgtttagt gttgtggctt tggcatagac ttctcttggt aataatgcct    13920

tgcaatgcaa aatttcaatt atcaaattct attatgttct caccttatgg taacagctta    13980

ccctgtggaa gatgagattc ttgagttgag tcattgccaa tttttggcat tagcttttga    14040

attagtgaat tttgacaaaa attaccgtga cactgatttt gttgaagctc ttaagtgtag    14100

tttttacaaa atttcagtgg ctcgttgtga ttatgtcaaa ctcacggcga atgtagttct    14160

tacagaattt cagtggctcc ctgcaggatc ccaatggcgc gcctagctaa ctagctagcc    14220

acgtgactcg cagaacgttg tgtggcgaga cggaaagaaa gtcacgcctc caaagagtgc    14280

agcatctctt ctggctctca cggtcctctg tggatccatc gatatcgaat tcctgcaggc    14340

tcgaggtcat tcatatgctt gagaagagag tcgggatagt ccaaaataaa acaaaggtaa    14400

gattacctgg tcaaaagtga aaacatcagt taaaaggtgg tataaagtaa aatatcggta    14460

ataaaaggtg gcccaaagtg aaatttactc ttttctacta ttataaaaat tgaggatgtt    14520

tttgtcggta ctttgatacg tcatttttgt atgaattggt ttttaagttt attcgctttt    14580

ggaaatgcat atctgtattt gagtcgggtt ttaagttcgt ttgcttttgt aaatacagag    14640

ggatttgtat aagaaatatc tttagaaaaa cccatatgct aatttgacat aatttttgag    14700

aaaaatatat attcaggcga attctcacaa tgaacaataa taagattaaa atagctttcc    14760

cccgttgcag cgcatgggta ttttttctag taaaaataaa agataaactt agactcaaaa    14820

catttacaaa aacaacccct aaagttccta aagcccaaag tgctatccac gatccatagc    14880

aagcccagcc caacccaacc caacccaacc caccccagtc cagccaactg gacaatagtc    14940

tccacacccc cccactatca ccgtgagttg tccgcacgca ccgcacgtct cgcagccaaa    15000

aaaaaaaaga aagaaaaaaa agaaaaagaa aaaacagcag gtgggtccgg gtcgtggggg    15060

ccggaaacgc gaggaggatc gcgagccagc gacgaggagc ttaggcctca tcgttgaaga    15120

tgcctctgcc gacagtggtc ccaaagatgg acccccaccc acgaggagca tcgtggaaaa    15180

agaagacgtt ccaaccacgt cttcaaagca agtggattga tgtgatatct ccactgacgt    15240

aagggatgac gcacaatccc actatccttc gaggcctcat cgttgaagat gcctctgccg    15300

acagtggtcc caaagatgga cccccaccca cgaggagcat cgtggaaaaa gaagacgttc    15360

caaccacgtc ttcaaagcaa gtggattgat gtgatatctc cactgacgta agggatgacg    15420

cacaatccca ctatccttcg aagctccctc cctccgcttc caaagaaacg ccccccatcg    15480

ccactatata catacccccc cctctcctcc catcccccca acccttctag aaccatcttc    15540

cacacactca agccacacta ttggagaaca cacagggaca acacaccata agatccaagg    15600

gaggcctccg ccgccgccgg taaccacccc gcccctctcc tctttctttc tccgtttttt    15660

tttccgtctc ggtctcgatc tttggccttg gtagtttggg tgggcgagag gcggcttcgt    15720

gcgcgcccag atcggtgcgc gggaggggcg ggatctcgcg gctggggctc tcgccggcgt    15780

ggatccggcc cggatctcgc ggggaatggg gctctcggat gtagatctgc gatccgccgt    15840

tgttggggga gatgatgggg ggtttaaaat ttccgccgtg ctaaacaaga tcaggaagag    15900

gggaaaaggg cactatggtt tatattttta tatatttctg ctgcttcgtc aggcttagat    15960

gtgctagatc tttctttctt ctttttgtgg gtagaatttg aatccctcag cattgttcat    16020

cggtagtttt tcttttcatg atttgtgaca aatgcagcct cgtgcggagc ttttttgtag    16080

gtagaaggcg gccgcatggc ccagtctaag cacgggttga cgaaggagat gactatgaag    16140

tatcgcatgg aaggctgcgt tgacggccac aaattcgtca ttaccggcga gggcatcggc    16200

taccccttta aggtaagttt ctgcttctac ctttgatata tatataataa ttatcattaa    16260

ttagtagtaa tataatattt caaatatttt tttcaaaata aaagaatgta gtatatagca    16320

attgcttttc tgtagtttat aagtgtgtat attttaattt ataacttttc taatatatga    16380

ccaaaatttg ttgatgtgca gggcaagcaa gcgataaacc tgtgcgtggt ggagggtggc    16440

cctctgccct tcgccgagga tatactctca gccgccttca tgtacgggaa tcgggtgttc    16500

acggagtacc cgcaagacat cgtggactac ttcaagaact cctgccccgc cggatacaca    16560

tgggaccgtt ccttcctctt cgaggacgga gccgtttgca tctgcaacgc ggacatcacc    16620

gtgtccgtcg aggagaactg catgtaccac gagtcaaagt tctatggagt gaacttcccg    16680

gccgatggtc ccgtgatgaa gaaaatgacg gacaactggg agccgtcgtg cgagaaaatc    16740

attcccgtcc caaaacaggg aatcctcaag ggcgacgtgt cgatgtacct acttctcaag    16800

gacggtggac ggctacggtg ccagttcgac actgtttaca aggcgaagtc ggtgccgagg    16860

aagatgccgg actggcactt tatccagcac aagctgacaa gggaggacag aagcgacgct    16920

aagaaccaga aatggcacct caccgagcac gccatcgcca gtggctctgc gctgcccggg    16980

tgaccctgca atgtgaccct agacttgtcc atcttctgga ttggccaact taattaatgt    17040

atgaaataaa aggatgcaca catagtgaca tgctaatcac tataatgtgg gcatcaaagt    17100

tgtgtgttat gtgtaattac taattatctg aataagagaa agagatcatc catatttctt    17160

atcctaaatg aatgtcacgt gtctttataa ttctttgatg aaccagatgc attttattaa    17220

ccaattccat atacatataa atattaatca tatataatta atatcaattg ggttagcaaa    17280

acaaatctag tctaggtgtg ttttgctaat tattggggga tagtgcaaaa agaaatctac    17340

gttctcaata attcagatag aaaacttaat aaagtgagat aatttacata gattgctttt    17400

atcctttgat atatgtgaaa ccatgcatga tataaggaaa atagatagag aaataatttt    17460

ttacatcgtt gaatatgtaa acaatttaat tcaagaagct aggaatataa atattgagga    17520

gtttatgatt attattatta ttttgatgtt caatgaagtt ttttttaatt tcatatgaag    17580

tatacaaaaa ttcttcatag atttttgttt ctatgccgta gttatcttta atatatttgt    17640

ggttgaagaa atttattgct agaaacgaat ggattgtcaa ttttttttta aagcaaatat    17700

atatgaaatt atactgtata ttattttagt catgattaaa atgtggcctt aattgaatca    17760

tctttctcat tcattttttc aaaagcatat caggatgatt gatatttatc tattttaaaa    17820

attaatttaa gggttcaaat taaatttaac ttaaaagtgt cctaaccgta gttaaaggtt    17880

tactttaaaa aaatactatg aaaaatctaa tcttctatga atcgagggcc cggccgtgac    17940

ggccacgagc gaactcctgc aggcgataaa aatgttttaa acgatatata ttataaaaaa    18000

aaacgtttca aaaataaata caaaaatgtt tttaaatata tataatttaa ctcattaaag    18060

aaaataaaaa tgcaagtgcg gtgacaagac aagctaaaag ttgcaaaaga aatggcaggg    18120

ctataaggct cacctactcc tggatttacc aaattttggt tcgtccctat actcgaaaaa    18180

taaaacaaaa taaatttcag tatcttcgtt tttgtatgct ttgactgtga ggcgaggcca    18240

actttcttct tctgtctgag atgaattttg tttgcctcct gtgaaggatg tatcattcaa    18300

agtgaatgtt ttgcaactgc cagtagtccc acatcgacca aatattctta ttacagtgtg    18360

tttatatagc acctggagaa ggaatgggtt gtttcaaaga ttaaataatt tctactaagt    18420

gtagattgcc gttaatttga gagtccaagt aatttctact aagtgtagat ttttttttgc    18480

ggccgcacaa caaacgcgcc ggcga                                          18505


<210>  116
<211>  18472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3095 Full Plasmid Sequence

<400>  116
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cgtccaagct ggagaagttt acaaactgtt acagcctctc caaaaccctc aggtttaaag     9780

cgatcccggt gggcaagacc caggagaaca tcgacaacaa gaggctcctg gtggaagacg     9840

agaagcgcgc cgaagactac aagggcgtga agaagctgct cgataggtac tacctcagct     9900

ttattaacga cgtgctgcac agcatcaaac tcaagaatct caacaactac atctccctct     9960

tccgcaaaaa gacccgcacc gagaaggaga acaaggagct ggagaacctg gagatcaacc    10020

tccgcaagga aatcgccaaa gcgttcaagg gcaatgaagg gtacaagagc ctcttcaaga    10080

aagacatcat cgaaactatc ctcccagagt ttctcgatga caaggacgag atcgcgctgg    10140

tgaactcctt taacgggttc acaaccgcgt ttaccggctt ctttgataac agggaaaata    10200

tgttctccga ggaggccaag tccaccagca tcgccttcag gtgtatcaac gagaacctca    10260

cccgctacat ttccaatatg gacattttcg agaaggtgga tgcgatcttc gataagcacg    10320

aggtgcagga gatcaaagag aagattctca attccgatta tgacgtcgag gatttcttcg    10380

aaggggagtt ctttaatttt gtgctcacac aagagggcat tgacgtgtac aacgcgatta    10440

tcgggggctt cgtcacagag tccggggaga agattaaggg gctgaatgag tacatcaatc    10500

tgtacaatca gaagaccaag cagaaactgc cgaaattcaa gccgctctac aagcaagtcc    10560

tgtccgatag ggaaagcctc tccttctacg gcgagggcta taccagcgac gaggaggtgc    10620

tggaagtctt ccgcaacaca ctgaataaga atagcgagat tttctcctcc atcaagaagc    10680

tcgagaagct ctttaagaac tttgacgagt acagctccgc cgggattttc gtgaagaacg    10740

ggccggcgat cagcaccatc tccaaggaca tctttggcga gtggaacgtc atcagggaca    10800

agtggaacgc cgagtacgac gacatccacc tgaagaagaa ggcggtggtg accgagaagt    10860

atgaggacga tcgcaggaag tccttcaaaa aaatcggctc cttcagcctc gaacagctcc    10920

aggagtatgc cgatgcggat ctgtccgtcg tcgagaagct gaaggaaatc atcattcaga    10980

aggtcgacga gatctataaa gtgtacgggt ccagcgagaa gctgttcgac gccgactttg    11040

tgctcgagaa gtccctcaaa aagaatgacg ccgtggtggc cattatgaaa gacctgctcg    11100

actccgtgaa gtccttcgaa aattacatta aagcgttctt tggggagggg aaggaaacta    11160

acagggatga gtccttctat ggcgactttg tcctcgcgta cgacatcctg ctgaaggtcg    11220

accacattta cgacgcgatc cgcaactacg tgacacagaa gccgtactcc aaagacaagt    11280

tcaagctgta cttccagaac ccgcaattta tggggggctg ggacaaggat aaagagacag    11340

actaccgcgc gacaattctc cgctatggct ccaaatacta tctggccatc atggacaaga    11400

agtacgcgaa gtgcctgcag aagatcgaca aagacgacgt caatggcaac tatgaaaaga    11460

tcaactacaa gctgctgccg ggtccgaaca agatgctccc gaaggtgttc ttcagcaaga    11520

agtggatggc ctactacaat ccaagcgagg atattcagaa aatctataaa aacgggacct    11580

tcaagaaggg ggacatgttt aacctcaacg actgccacaa gctcattgat ttcttcaagg    11640

atagcatttc ccgctacccg aaatggtcca atgcgtacga ttttaacttc tccgagacag    11700

aaaagtacaa agacatcgcg ggcttttaca gggaggtgga ggagcaaggg tataaagttt    11760

cttttgaatc cgcgagcaag aaggaagtcg acaagctcgt cgaggagggc aagctctaca    11820

tgttccaaat ttataacaag gacttttccg acaagagcca tgggacccca aacctccaca    11880

ccatgtactt caaactgctc tttgacgaga acaaccacgg gcaaatcagg ctgagcggcg    11940

gcgccgaatt attcatgcgc agggcctccc tcaagaagga agagctggtc gtccatccag    12000

ccaattcccc gatcgcgaac aagaacccgg acaatccgaa aaagaccacc accctgtcct    12060

acgacgtcta caaggacaaa cgcttcagcg aagaccagta cgaattacac atcccaattg    12120

cgattaataa gtgcccaaag aatatcttca aaattaatac agaggtcagg gtgctgctca    12180

aacacgacga caatccgtat gtcatcggca ttgacagggg cgagcgcaat ctgctctata    12240

tcgtggtcgt ggatgggaag ggcaatattg tggagcagta ctccctgaac gagattatca    12300

acaacttcaa tgggattagg attaagaccg actatcacag cctgctcgac aagaaagaaa    12360

aagagaggtt tgaggcccgc caaaactgga cctccattga gaatatcaaa gaattaaagg    12420

ccggctatat ttcccaagtc gtccacaaga tctgcgagct ggtggagaaa tatgacgccg    12480

tgattgcgct cgaagactta aattctgggt tcaagaactc ccgcgtgaag gtggaaaaac    12540

aggtgtatca gaaattcgag aaaatgctga tcgacaaact caattatatg gtggataaga    12600

agtccaaccc gtgtgccaca gggggcgcgc tgaagggcta tcagatcacc aacaagttcg    12660

agagcttcaa gagcatgagc acccagaacg ggtttatttt ctacatcccg gcgtggctca    12720

cctccaagat tgacccgagc accggcttcg tgaacctcct gaagacaaag tatacctcca    12780

ttgccgacag caagaagttt atctcctcct tcgaccgcat tatgtatgtg ccggaggagg    12840

acctcttcga gttcgccctc gactacaaaa acttcagccg cacagatgcg gattacatca    12900

agaagtggaa gctgtactcc tacgggaaca ggatccgcat cttcaggaat ccaaaaaaaa    12960

ataacgtctt tgactgggag gaagtgtgcc tgacatccgc ctacaaggaa ctgttcaata    13020

aatacggcat caattaccag cagggcgaca ttcgcgccct cctctgtgag cagtccgaca    13080

aagcgtttta ctccagcttc atggccctca tgtccctgat gctccaaatg aggaatagca    13140

tcacagggcg caccgacgtc gacttcctca tcagcccggt gaagaactcc gacgggatct    13200

tttacgactc ccgcaactat gaggcgcaag agaatgcgat cctcccgaag aacgccgatg    13260

cgaacggggc ctataatatc gccaggaaag tgctctgggc catcgggcag ttcaaaaagg    13320

cggaggatga gaagctcgac aaggtgaaaa ttgccatttc caacaaggag tggctggagt    13380

acgcgcagac ctccgtgaag cacggctcct ccgagacacc aggcacctcc gagagcgcga    13440

cgcccgaggg cggctccggc ggctccggca gcgcagagta tgttcgtgcc ctttttgatt    13500

ttaacggcaa tgatgaagag gatttgccct tcaagaaagg tgacatcctc cgaataaggg    13560

acaaaccaga agaacaatgg tggaatgctg aagattctga agggaagaga ggaatgattc    13620

ctgtccctta tgtggagaag tactgaaagg gctctctgtc atgatttcat actttcatta    13680

ttgagctctg taattacaat tatgaccatg agaacatctc ttattgtgtg gccttttaat    13740

tgctgatgtt agtactgaac caaagcttat cgtgatgatg taaaagcaat aagtacttgt    13800

ttgtagcttc tttgtgtctc cctttgggct taatacatct gtttagtgtt gtggctttgg    13860

catagacttc tcttggtaat aatgccttgc aatgcaaaat ttcaattatc aaattctatt    13920

atgttctcac cttatggtaa cagcttaccc tgtggaagat gagattcttg agttgagtca    13980

ttgccaattt ttggcattag cttttgaatt agtgaatttt gacaaaaatt accgtgacac    14040

tgattttgtt gaagctctta agtgtagttt ttacaaaatt tcagtggctc gttgtgatta    14100

tgtcaaactc acggcgaatg tagttcttac agaatttcag tggctccctg caggatccca    14160

atggcgcgcc tagctaacta gctagccacg tgactcgcag aacgttgtgt ggcgagacgg    14220

aaagaaagtc acgcctccaa agagtgcagc atctcttctg gctctcacgg tcctctgtgg    14280

atccatcgat atcgaattcc tgcaggctcg aggtcattca tatgcttgag aagagagtcg    14340

ggatagtcca aaataaaaca aaggtaagat tacctggtca aaagtgaaaa catcagttaa    14400

aaggtggtat aaagtaaaat atcggtaata aaaggtggcc caaagtgaaa tttactcttt    14460

tctactatta taaaaattga ggatgttttt gtcggtactt tgatacgtca tttttgtatg    14520

aattggtttt taagtttatt cgcttttgga aatgcatatc tgtatttgag tcgggtttta    14580

agttcgtttg cttttgtaaa tacagaggga tttgtataag aaatatcttt agaaaaaccc    14640

atatgctaat ttgacataat ttttgagaaa aatatatatt caggcgaatt ctcacaatga    14700

acaataataa gattaaaata gctttccccc gttgcagcgc atgggtattt tttctagtaa    14760

aaataaaaga taaacttaga ctcaaaacat ttacaaaaac aacccctaaa gttcctaaag    14820

cccaaagtgc tatccacgat ccatagcaag cccagcccaa cccaacccaa cccaacccac    14880

cccagtccag ccaactggac aatagtctcc acaccccccc actatcaccg tgagttgtcc    14940

gcacgcaccg cacgtctcgc agccaaaaaa aaaaagaaag aaaaaaaaga aaaagaaaaa    15000

acagcaggtg ggtccgggtc gtgggggccg gaaacgcgag gaggatcgcg agccagcgac    15060

gaggagctta ggcctcatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc    15120

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt    15180

ggattgatgt gatatctcca ctgacgtaag ggatgacgca caatcccact atccttcgag    15240

gcctcatcgt tgaagatgcc tctgccgaca gtggtcccaa agatggaccc ccacccacga    15300

ggagcatcgt ggaaaaagaa gacgttccaa ccacgtcttc aaagcaagtg gattgatgtg    15360

atatctccac tgacgtaagg gatgacgcac aatcccacta tccttcgaag ctccctccct    15420

ccgcttccaa agaaacgccc cccatcgcca ctatatacat acccccccct ctcctcccat    15480

ccccccaacc cttctagaac catcttccac acactcaagc cacactattg gagaacacac    15540

agggacaaca caccataaga tccaagggag gcctccgccg ccgccggtaa ccaccccgcc    15600

cctctcctct ttctttctcc gttttttttt ccgtctcggt ctcgatcttt ggccttggta    15660

gtttgggtgg gcgagaggcg gcttcgtgcg cgcccagatc ggtgcgcggg aggggcggga    15720

tctcgcggct ggggctctcg ccggcgtgga tccggcccgg atctcgcggg gaatggggct    15780

ctcggatgta gatctgcgat ccgccgttgt tgggggagat gatggggggt ttaaaatttc    15840

cgccgtgcta aacaagatca ggaagagggg aaaagggcac tatggtttat atttttatat    15900

atttctgctg cttcgtcagg cttagatgtg ctagatcttt ctttcttctt tttgtgggta    15960

gaatttgaat ccctcagcat tgttcatcgg tagtttttct tttcatgatt tgtgacaaat    16020

gcagcctcgt gcggagcttt tttgtaggta gaaggcggcc gcatggccca gtctaagcac    16080

gggttgacga aggagatgac tatgaagtat cgcatggaag gctgcgttga cggccacaaa    16140

ttcgtcatta ccggcgaggg catcggctac ccctttaagg taagtttctg cttctacctt    16200

tgatatatat ataataatta tcattaatta gtagtaatat aatatttcaa atattttttt    16260

caaaataaaa gaatgtagta tatagcaatt gcttttctgt agtttataag tgtgtatatt    16320

ttaatttata acttttctaa tatatgacca aaatttgttg atgtgcaggg caagcaagcg    16380

ataaacctgt gcgtggtgga gggtggccct ctgcccttcg ccgaggatat actctcagcc    16440

gccttcatgt acgggaatcg ggtgttcacg gagtacccgc aagacatcgt ggactacttc    16500

aagaactcct gccccgccgg atacacatgg gaccgttcct tcctcttcga ggacggagcc    16560

gtttgcatct gcaacgcgga catcaccgtg tccgtcgagg agaactgcat gtaccacgag    16620

tcaaagttct atggagtgaa cttcccggcc gatggtcccg tgatgaagaa aatgacggac    16680

aactgggagc cgtcgtgcga gaaaatcatt cccgtcccaa aacagggaat cctcaagggc    16740

gacgtgtcga tgtacctact tctcaaggac ggtggacggc tacggtgcca gttcgacact    16800

gtttacaagg cgaagtcggt gccgaggaag atgccggact ggcactttat ccagcacaag    16860

ctgacaaggg aggacagaag cgacgctaag aaccagaaat ggcacctcac cgagcacgcc    16920

atcgccagtg gctctgcgct gcccgggtga ccctgcaatg tgaccctaga cttgtccatc    16980

ttctggattg gccaacttaa ttaatgtatg aaataaaagg atgcacacat agtgacatgc    17040

taatcactat aatgtgggca tcaaagttgt gtgttatgtg taattactaa ttatctgaat    17100

aagagaaaga gatcatccat atttcttatc ctaaatgaat gtcacgtgtc tttataattc    17160

tttgatgaac cagatgcatt ttattaacca attccatata catataaata ttaatcatat    17220

ataattaata tcaattgggt tagcaaaaca aatctagtct aggtgtgttt tgctaattat    17280

tgggggatag tgcaaaaaga aatctacgtt ctcaataatt cagatagaaa acttaataaa    17340

gtgagataat ttacatagat tgcttttatc ctttgatata tgtgaaacca tgcatgatat    17400

aaggaaaata gatagagaaa taatttttta catcgttgaa tatgtaaaca atttaattca    17460

agaagctagg aatataaata ttgaggagtt tatgattatt attattattt tgatgttcaa    17520

tgaagttttt tttaatttca tatgaagtat acaaaaattc ttcatagatt tttgtttcta    17580

tgccgtagtt atctttaata tatttgtggt tgaagaaatt tattgctaga aacgaatgga    17640

ttgtcaattt ttttttaaag caaatatata tgaaattata ctgtatatta ttttagtcat    17700

gattaaaatg tggccttaat tgaatcatct ttctcattca ttttttcaaa agcatatcag    17760

gatgattgat atttatctat tttaaaaatt aatttaaggg ttcaaattaa atttaactta    17820

aaagtgtcct aaccgtagtt aaaggtttac tttaaaaaaa tactatgaaa aatctaatct    17880

tctatgaatc gagggcccgg ccgtgacggc cacgagcgaa ctcctgcagg cgataaaaat    17940

gttttaaacg atatatatta taaaaaaaaa cgtttcaaaa ataaatacaa aaatgttttt    18000

aaatatatat aatttaactc attaaagaaa ataaaaatgc aagtgcggtg acaagacaag    18060

ctaaaagttg caaaagaaat ggcagggcta taaggctcac ctactcctgg atttaccaaa    18120

ttttggttcg tccctatact cgaaaaataa aacaaaataa atttcagtat cttcgttttt    18180

gtatgctttg actgtgaggc gaggccaact ttcttcttct gtctgagatg aattttgttt    18240

gcctcctgtg aaggatgtat cattcaaagt gaatgttttg caactgccag tagtcccaca    18300

tcgaccaaat attcttatta cagtgtgttt atatagcacc tggagaagga atgggttgtt    18360

tcaaagatta aataatttct actaagtgta gattgccgtt aatttgagag tccaagtaat    18420

ttctactaag tgtagatttt tttttgcggc cgcacaacaa acgcgccggc ga            18472


<210>  117
<211>  19066
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3097 Full Plasmid Sequence

<400>  117
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cgtccaagct ggagaagttt acaaactgtt acagcctctc caaaaccctc aggtttaaag     9780

cgatcccggt gggcaagacc caggagaaca tcgacaacaa gaggctcctg gtggaagacg     9840

agaagcgcgc cgaagactac aagggcgtga agaagctgct cgataggtac tacctcagct     9900

ttattaacga cgtgctgcac agcatcaaac tcaagaatct caacaactac atctccctct     9960

tccgcaaaaa gacccgcacc gagaaggaga acaaggagct ggagaacctg gagatcaacc    10020

tccgcaagga aatcgccaaa gcgttcaagg gcaatgaagg gtacaagagc ctcttcaaga    10080

aagacatcat cgaaactatc ctcccagagt ttctcgatga caaggacgag atcgcgctgg    10140

tgaactcctt taacgggttc acaaccgcgt ttaccggctt ctttgataac agggaaaata    10200

tgttctccga ggaggccaag tccaccagca tcgccttcag gtgtatcaac gagaacctca    10260

cccgctacat ttccaatatg gacattttcg agaaggtgga tgcgatcttc gataagcacg    10320

aggtgcagga gatcaaagag aagattctca attccgatta tgacgtcgag gatttcttcg    10380

aaggggagtt ctttaatttt gtgctcacac aagagggcat tgacgtgtac aacgcgatta    10440

tcgggggctt cgtcacagag tccggggaga agattaaggg gctgaatgag tacatcaatc    10500

tgtacaatca gaagaccaag cagaaactgc cgaaattcaa gccgctctac aagcaagtcc    10560

tgtccgatag ggaaagcctc tccttctacg gcgagggcta taccagcgac gaggaggtgc    10620

tggaagtctt ccgcaacaca ctgaataaga atagcgagat tttctcctcc atcaagaagc    10680

tcgagaagct ctttaagaac tttgacgagt acagctccgc cgggattttc gtgaagaacg    10740

ggccggcgat cagcaccatc tccaaggaca tctttggcga gtggaacgtc atcagggaca    10800

agtggaacgc cgagtacgac gacatccacc tgaagaagaa ggcggtggtg accgagaagt    10860

atgaggacga tcgcaggaag tccttcaaaa aaatcggctc cttcagcctc gaacagctcc    10920

aggagtatgc cgatgcggat ctgtccgtcg tcgagaagct gaaggaaatc atcattcaga    10980

aggtcgacga gatctataaa gtgtacgggt ccagcgagaa gctgttcgac gccgactttg    11040

tgctcgagaa gtccctcaaa aagaatgacg ccgtggtggc cattatgaaa gacctgctcg    11100

actccgtgaa gtccttcgaa aattacatta aagcgttctt tggggagggg aaggaaacta    11160

acagggatga gtccttctat ggcgactttg tcctcgcgta cgacatcctg ctgaaggtcg    11220

accacattta cgacgcgatc cgcaactacg tgacacagaa gccgtactcc aaagacaagt    11280

tcaagctgta cttccagaac ccgcaattta tggggggctg ggacaaggat aaagagacag    11340

actaccgcgc gacaattctc cgctatggct ccaaatacta tctggccatc atggacaaga    11400

agtacgcgaa gtgcctgcag aagatcgaca aagacgacgt caatggcaac tatgaaaaga    11460

tcaactacaa gctgctgccg ggtccgaaca agatgctccc gaaggtgttc ttcagcaaga    11520

agtggatggc ctactacaat ccaagcgagg atattcagaa aatctataaa aacgggacct    11580

tcaagaaggg ggacatgttt aacctcaacg actgccacaa gctcattgat ttcttcaagg    11640

atagcatttc ccgctacccg aaatggtcca atgcgtacga ttttaacttc tccgagacag    11700

aaaagtacaa agacatcgcg ggcttttaca gggaggtgga ggagcaaggg tataaagttt    11760

cttttgaatc cgcgagcaag aaggaagtcg acaagctcgt cgaggagggc aagctctaca    11820

tgttccaaat ttataacaag gacttttccg acaagagcca tgggacccca aacctccaca    11880

ccatgtactt caaactgctc tttgacgaga acaaccacgg gcaaatcagg ctgagcggcg    11940

gcgccgaatt attcatgcgc agggcctccc tcaagaagga agagctggtc gtccatccag    12000

ccaattcccc gatcgcgaac aagaacccgg acaatccgaa aaagaccacc accctgtcct    12060

acgacgtcta caaggacaaa cgcttcagcg aagaccagta cgaattacac atcccaattg    12120

cgattaataa gtgcccaaag aatatcttca aaattaatac agaggtcagg gtgctgctca    12180

aacacgacga caatccgtat gtcatcggca ttgacagggg cgagcgcaat ctgctctata    12240

tcgtggtcgt ggatgggaag ggcaatattg tggagcagta ctccctgaac gagattatca    12300

acaacttcaa tgggattagg attaagaccg actatcacag cctgctcgac aagaaagaaa    12360

aagagaggtt tgaggcccgc caaaactgga cctccattga gaatatcaaa gaattaaagg    12420

ccggctatat ttcccaagtc gtccacaaga tctgcgagct ggtggagaaa tatgacgccg    12480

tgattgcgct cgaagactta aattctgggt tcaagaactc ccgcgtgaag gtggaaaaac    12540

aggtgtatca gaaattcgag aaaatgctga tcgacaaact caattatatg gtggataaga    12600

agtccaaccc gtgtgccaca gggggcgcgc tgaagggcta tcagatcacc aacaagttcg    12660

agagcttcaa gagcatgagc acccagaacg ggtttatttt ctacatcccg gcgtggctca    12720

cctccaagat tgacccgagc accggcttcg tgaacctcct gaagacaaag tatacctcca    12780

ttgccgacag caagaagttt atctcctcct tcgaccgcat tatgtatgtg ccggaggagg    12840

acctcttcga gttcgccctc gactacaaaa acttcagccg cacagatgcg gattacatca    12900

agaagtggaa gctgtactcc tacgggaaca ggatccgcat cttcaggaat ccaaaaaaaa    12960

ataacgtctt tgactgggag gaagtgtgcc tgacatccgc ctacaaggaa ctgttcaata    13020

aatacggcat caattaccag cagggcgaca ttcgcgccct cctctgtgag cagtccgaca    13080

aagcgtttta ctccagcttc atggccctca tgtccctgat gctccaaatg aggaatagca    13140

tcacagggcg caccgacgtc gacttcctca tcagcccggt gaagaactcc gacgggatct    13200

tttacgactc ccgcaactat gaggcgcaag agaatgcgat cctcccgaag aacgccgatg    13260

cgaacggggc ctataatatc gccaggaaag tgctctgggc catcgggcag ttcaaaaagg    13320

cggaggatga gaagctcgac aaggtgaaaa ttgccatttc caacaaggag tggctggagt    13380

acgcgcagac ctccgtgaag cacggctcct ccgagacacc aggcacctcc gagagcgcga    13440

cgcccgaggg cggctccggc ggctccggca gcggtccaga catcgttatg actcaatccc    13500

cctcaagcct ttcagcctcc gtgggcgaca gagttaccat tacctgccgc tcaagcactg    13560

gagcagtgac cacttctaac tacgctagct gggtgcagga gaagccagga aagctgttca    13620

aggggctgat tggaggcaca aacaatagag cccctggcgt gccatccagg ttttctggaa    13680

gcctgattgg cgataaggca acactgacca tctctagcct gcagcccgag gacttcgcta    13740

cctacttttg cgccctgtgg tatagcaatc actgggtgtt cggtcagggg actaaggtgg    13800

aactgaagag aggtggggga ggctccggtg ggggaggctc aggtggggga ggctcctcag    13860

gtgggggatc tgaggtgaag ctgctggaaa gcggcggtgg gctggtgcag cccggaggct    13920

ccctgaagct gtcatgtgcc gtgtctggat tttcactgac cgattacggc gtgaactggg    13980

tgagacaggc ccctggaagg ggactggagt ggattggagt gatttgggga gatgggatca    14040

cagactacaa ttccgcactg aaggatagat tcattatctc aaaggacaac ggaaagaaca    14100

ccgtgtatct gcagatgtct aaggtgagga gcgatgacac tgccctgtac tattgcgtga    14160

cagggctgtt tgactattgg gggcaaggca ctctggttac cgtgagcagc tatccatacg    14220

atgttcccga ctacgcttga aagggctctc tgtcatgatt tcatactttc attattgagc    14280

tctgtaatta caattatgac catgagaaca tctcttattg tgtggccttt taattgctga    14340

tgttagtact gaaccaaagc ttatcgtgat gatgtaaaag caataagtac ttgtttgtag    14400

cttctttgtg tctccctttg ggcttaatac atctgtttag tgttgtggct ttggcataga    14460

cttctcttgg taataatgcc ttgcaatgca aaatttcaat tatcaaattc tattatgttc    14520

tcaccttatg gtaacagctt accctgtgga agatgagatt cttgagttga gtcattgcca    14580

atttttggca ttagcttttg aattagtgaa ttttgacaaa aattaccgtg acactgattt    14640

tgttgaagct cttaagtgta gtttttacaa aatttcagtg gctcgttgtg attatgtcaa    14700

actcacggcg aatgtagttc ttacagaatt tcagtggctc cctgcaggat cccaatggcg    14760

cgcctagcta actagctagc cacgtgactc gcagaacgtt gtgtggcgag acggaaagaa    14820

agtcacgcct ccaaagagtg cagcatctct tctggctctc acggtcctct gtggatccat    14880

cgatatcgaa ttcctgcagg ctcgaggtca ttcatatgct tgagaagaga gtcgggatag    14940

tccaaaataa aacaaaggta agattacctg gtcaaaagtg aaaacatcag ttaaaaggtg    15000

gtataaagta aaatatcggt aataaaaggt ggcccaaagt gaaatttact cttttctact    15060

attataaaaa ttgaggatgt ttttgtcggt actttgatac gtcatttttg tatgaattgg    15120

tttttaagtt tattcgcttt tggaaatgca tatctgtatt tgagtcgggt tttaagttcg    15180

tttgcttttg taaatacaga gggatttgta taagaaatat ctttagaaaa acccatatgc    15240

taatttgaca taatttttga gaaaaatata tattcaggcg aattctcaca atgaacaata    15300

ataagattaa aatagctttc ccccgttgca gcgcatgggt attttttcta gtaaaaataa    15360

aagataaact tagactcaaa acatttacaa aaacaacccc taaagttcct aaagcccaaa    15420

gtgctatcca cgatccatag caagcccagc ccaacccaac ccaacccaac ccaccccagt    15480

ccagccaact ggacaatagt ctccacaccc ccccactatc accgtgagtt gtccgcacgc    15540

accgcacgtc tcgcagccaa aaaaaaaaag aaagaaaaaa aagaaaaaga aaaaacagca    15600

ggtgggtccg ggtcgtgggg gccggaaacg cgaggaggat cgcgagccag cgacgaggag    15660

cttaggcctc atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc    15720

cacgaggagc atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg    15780

atgtgatatc tccactgacg taagggatga cgcacaatcc cactatcctt cgaggcctca    15840

tcgttgaaga tgcctctgcc gacagtggtc ccaaagatgg acccccaccc acgaggagca    15900

tcgtggaaaa agaagacgtt ccaaccacgt cttcaaagca agtggattga tgtgatatct    15960

ccactgacgt aagggatgac gcacaatccc actatccttc gaagctccct ccctccgctt    16020

ccaaagaaac gccccccatc gccactatat acataccccc ccctctcctc ccatcccccc    16080

aacccttcta gaaccatctt ccacacactc aagccacact attggagaac acacagggac    16140

aacacaccat aagatccaag ggaggcctcc gccgccgccg gtaaccaccc cgcccctctc    16200

ctctttcttt ctccgttttt ttttccgtct cggtctcgat ctttggcctt ggtagtttgg    16260

gtgggcgaga ggcggcttcg tgcgcgccca gatcggtgcg cgggaggggc gggatctcgc    16320

ggctggggct ctcgccggcg tggatccggc ccggatctcg cggggaatgg ggctctcgga    16380

tgtagatctg cgatccgccg ttgttggggg agatgatggg gggtttaaaa tttccgccgt    16440

gctaaacaag atcaggaaga ggggaaaagg gcactatggt ttatattttt atatatttct    16500

gctgcttcgt caggcttaga tgtgctagat ctttctttct tctttttgtg ggtagaattt    16560

gaatccctca gcattgttca tcggtagttt ttcttttcat gatttgtgac aaatgcagcc    16620

tcgtgcggag cttttttgta ggtagaaggc ggccgcatgg cccagtctaa gcacgggttg    16680

acgaaggaga tgactatgaa gtatcgcatg gaaggctgcg ttgacggcca caaattcgtc    16740

attaccggcg agggcatcgg ctaccccttt aaggtaagtt tctgcttcta cctttgatat    16800

atatataata attatcatta attagtagta atataatatt tcaaatattt ttttcaaaat    16860

aaaagaatgt agtatatagc aattgctttt ctgtagttta taagtgtgta tattttaatt    16920

tataactttt ctaatatatg accaaaattt gttgatgtgc agggcaagca agcgataaac    16980

ctgtgcgtgg tggagggtgg ccctctgccc ttcgccgagg atatactctc agccgccttc    17040

atgtacggga atcgggtgtt cacggagtac ccgcaagaca tcgtggacta cttcaagaac    17100

tcctgccccg ccggatacac atgggaccgt tccttcctct tcgaggacgg agccgtttgc    17160

atctgcaacg cggacatcac cgtgtccgtc gaggagaact gcatgtacca cgagtcaaag    17220

ttctatggag tgaacttccc ggccgatggt cccgtgatga agaaaatgac ggacaactgg    17280

gagccgtcgt gcgagaaaat cattcccgtc ccaaaacagg gaatcctcaa gggcgacgtg    17340

tcgatgtacc tacttctcaa ggacggtgga cggctacggt gccagttcga cactgtttac    17400

aaggcgaagt cggtgccgag gaagatgccg gactggcact ttatccagca caagctgaca    17460

agggaggaca gaagcgacgc taagaaccag aaatggcacc tcaccgagca cgccatcgcc    17520

agtggctctg cgctgcccgg gtgaccctgc aatgtgaccc tagacttgtc catcttctgg    17580

attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac atgctaatca    17640

ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctaattatct gaataagaga    17700

aagagatcat ccatatttct tatcctaaat gaatgtcacg tgtctttata attctttgat    17760

gaaccagatg cattttatta accaattcca tatacatata aatattaatc atatataatt    17820

aatatcaatt gggttagcaa aacaaatcta gtctaggtgt gttttgctaa ttattggggg    17880

atagtgcaaa aagaaatcta cgttctcaat aattcagata gaaaacttaa taaagtgaga    17940

taatttacat agattgcttt tatcctttga tatatgtgaa accatgcatg atataaggaa    18000

aatagataga gaaataattt tttacatcgt tgaatatgta aacaatttaa ttcaagaagc    18060

taggaatata aatattgagg agtttatgat tattattatt attttgatgt tcaatgaagt    18120

tttttttaat ttcatatgaa gtatacaaaa attcttcata gatttttgtt tctatgccgt    18180

agttatcttt aatatatttg tggttgaaga aatttattgc tagaaacgaa tggattgtca    18240

attttttttt aaagcaaata tatatgaaat tatactgtat attattttag tcatgattaa    18300

aatgtggcct taattgaatc atctttctca ttcatttttt caaaagcata tcaggatgat    18360

tgatatttat ctattttaaa aattaattta agggttcaaa ttaaatttaa cttaaaagtg    18420

tcctaaccgt agttaaaggt ttactttaaa aaaatactat gaaaaatcta atcttctatg    18480

aatcgagggc ccggccgtga cggccacgag cgaactcctg caggcgataa aaatgtttta    18540

aacgatatat attataaaaa aaaacgtttc aaaaataaat acaaaaatgt ttttaaatat    18600

atataattta actcattaaa gaaaataaaa atgcaagtgc ggtgacaaga caagctaaaa    18660

gttgcaaaag aaatggcagg gctataaggc tcacctactc ctggatttac caaattttgg    18720

ttcgtcccta tactcgaaaa ataaaacaaa ataaatttca gtatcttcgt ttttgtatgc    18780

tttgactgtg aggcgaggcc aactttcttc ttctgtctga gatgaatttt gtttgcctcc    18840

tgtgaaggat gtatcattca aagtgaatgt tttgcaactg ccagtagtcc cacatcgacc    18900

aaatattctt attacagtgt gtttatatag cacctggaga aggaatgggt tgtttcaaag    18960

attaaataat ttctactaag tgtagattgc cgttaatttg agagtccaag taatttctac    19020

taagtgtaga tttttttttg cggccgcaca acaaacgcgc cggcga                   19066


<210>  118
<211>  16312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE768 Full Plasmid Sequence

<400>  118
cccataatag ctgtttgcca atcgttcttc ttggcgcgcc actgttaata atttttaaac       60

gtcagcgcac taaaaaaacg aaaagacgga cacgtgaaaa taaaaaacac acactagttt      120

atgacgcaat actattttac ttatgatttg ggtacattag acaaaaccgt gaaagagatg      180

tatcagctat gaaacctgta tacttcaata cagagactta ctcatatcgg atacgtacgc      240

acgaagtatc atattaatta ttttaatttt taataaatat tttatcggat acttatgtga      300

tactctacat atacacaagg atatttctaa gatactttat agatacgtat cctagaaaaa      360

catgaagagt aaaaaagtga gacaatgttg taaaaattca ttataaatgt atatgattca      420

attttagata tgcatcagta taattgattc tcgatgaaac acttaaaatt atatttcttg      480

tggaagaacg tagcgagaga ggtgattcag ttagacaaca ttaaataaaa ttaatgttaa      540

gttcttttaa tgatgtttct ctcaatatca catcatatga aaatgtaata tgatttataa      600

gaaaattttt aaaaaattta ttttaataat cacatgtact attttttaaa aattgtatct      660

tttataataa tacaataata aagagtaatc agtgttaatt tttcttcaaa tataagtttt      720

attataaatc attgttaacg tatcataagt cattaccgta tcgtatctta attttttttt      780

aaaaaccgct aattcacgta cccgtattgt attgtacccg cacctgtatc acaatcgatc      840

ttagttagaa gaattgtctc gaggcggtgc aagacagcat ataatagacg tggactctct      900

tataccaaac gttgtcgtat cacaaagggt taggtaacaa gtcacagttt gtccacgtgt      960

cacgttttaa ttggaagagg tgccgttggc gtaatataac agccaatcga tttttgctat     1020

aaaagcaaat caggtaaact aaacttcttc attcttttct tccccatcgc tacaaaaccg     1080

gttcctttgg aaaagagatt cattcaaacc tagcacccaa ttccgtttca aggtataatc     1140

tactttctat tcttcgatta ttttattatt attagctact atcgtttaat cgatcttttc     1200

ttttgatccg tcaaatttaa attcaattag ggttttgttc ttttctttca tctgattgaa     1260

atccttctga attgaaccgt ttacttgatt ttactgttta ttgtatgatt taatcctttg     1320

tttttcaaag acagtcttta gattgtgatt aggggttcat ataaattttt agatttggat     1380

ttttgtattg tatgattcaa aaaatacgtc ctttaattag attagtacat ggatattttt     1440

tacccgattt attgattgtc agggagaatt tgatgagcaa gtttttttga tgtctgttgt     1500

aaattgaatt gattataatt gctgatctgc tgcttccagt tttcataacc catattcttt     1560

taaccttgtt gtacacacaa tgaaaaattg gtgattgatt catttgtttt tctttgtttt     1620

ggattataca gggtggtacc aaaaaatggc gggatctaag aagagaagaa ttaaacaaga     1680

ttccaagctg gagaagttta caaactgtta cagcctctcc aaaaccctca ggtttaaagc     1740

gatcccggtg ggcaagaccc aggagaacat cgacaacaag aggctcctgg tggaagacga     1800

gaagcgcgcc gaagactaca agggcgtgaa gaagctgctc gataggtact acctcagctt     1860

tattaacgac gtgctgcaca gcatcaaact caagaatctc aacaactaca tctccctctt     1920

ccgcaaaaag acccgcaccg agaaggagaa caaggagctg gagaacctgg agatcaacct     1980

ccgcaaggaa atcgccaaag cgttcaaggg caatgaaggg tacaagagcc tcttcaagaa     2040

agacatcatc gaaactatcc tcccagagtt tctcgatgac aaggacgaga tcgcgctggt     2100

gaactccttt aacgggttca caaccgcgtt taccggcttc tttgataaca gggaaaatat     2160

gttctccgag gaggccaagt ccaccagcat cgccttcagg tgtatcaacg agaacctcac     2220

ccgctacatt tccaatatgg acattttcga gaaggtggat gcgatcttcg ataagcacga     2280

ggtgcaggag atcaaagaga agattctcaa ttccgattat gacgtcgagg atttcttcga     2340

aggggagttc tttaattttg tgctcacaca agagggcatt gacgtgtaca acgcgattat     2400

cgggggcttc gtcacagagt ccggggagaa gattaagggg ctgaatgagt acatcaatct     2460

gtacaatcag aagaccaagc agaaactgcc gaaattcaag ccgctctaca agcaagtcct     2520

gtccgatagg gaaagcctct ccttctacgg cgagggctat accagcgacg aggaggtgct     2580

ggaagtcttc cgcaacacac tgaataagaa tagcgagatt ttctcctcca tcaagaagct     2640

cgagaagctc tttaagaact ttgacgagta cagctccgcc gggattttcg tgaagaacgg     2700

gccggcgatc agcaccatct ccaaggacat ctttggcgag tggaacgtca tcagggacaa     2760

gtggaacgcc gagtacgacg acatccacct gaagaagaag gcggtggtga ccgagaagta     2820

tgaggacgat cgcaggaagt ccttcaaaaa aatcggctcc ttcagcctcg aacagctcca     2880

ggagtatgcc gatgcggatc tgtccgtcgt cgagaagctg aaggaaatca tcattcagaa     2940

ggtcgacgag atctataaag tgtacgggtc cagcgagaag ctgttcgacg ccgactttgt     3000

gctcgagaag tccctcaaaa agaatgacgc cgtggtggcc attatgaaag acctgctcga     3060

ctccgtgaag tccttcgaaa attacattaa agcgttcttt ggggagggga aggaaactaa     3120

cagggatgag tccttctatg gcgactttgt cctcgcgtac gacatcctgc tgaaggtcga     3180

ccacatttac gacgcgatcc gcaactacgt gacacagaag ccgtactcca aagacaagtt     3240

caagctgtac ttccagaacc cgcaatttat ggggggctgg gacaaggata aagagacaga     3300

ctaccgcgcg acaattctcc gctatggctc caaatactat ctggccatca tggacaagaa     3360

gtacgcgaag tgcctgcaga agatcgacaa agacgacgtc aatggcaact atgaaaagat     3420

caactacaag ctgctgccgg gcccgaacaa gatgctcccg aaggtgttct tcagcaagaa     3480

gtggatggcc tactacaatc caagcgagga tattcagaaa atctataaaa acgggacctt     3540

caagaagggg gacatgttta acctcaacga ctgccacaag ctcattgatt tcttcaagga     3600

tagcatttcc cgctacccga aatggtccaa tgcgtacgat tttaacttct ccgagacaga     3660

aaagtacaaa gacatcgcgg gcttttacag ggaggtggag gagcaagggt ataaagtttc     3720

ttttgaatcc gcgagcaaga aggaagtcga caagctcgtc gaggagggca agctctacat     3780

gttccaaatt tataacaagg acttttccga caagagccat gggaccccaa acctccacac     3840

catgtacttc aaactgctct ttgacgagaa caaccacggg caaatcaggc tgagcggcgg     3900

cgccgaatta ttcatgcgca gggcctccct caagaaggaa gagctggtcg tccatccagc     3960

caattccccg atcgcgaaca agaacccgga caatccgaaa aagaccacca ccctgtccta     4020

cgacgtctac aaggacaaac gcttcagcga agaccagtac gaattacaca tcccaattgc     4080

gattaataag tgcccaaaga atatcttcaa aattaataca gaggtcaggg tgctgctcaa     4140

acacgacgac aatccgtatg tcatcggcat tgacaggggc gagcgcaatc tgctctatat     4200

cgtggtcgtg gatgggaagg gcaatattgt ggagcagtac tccctgaacg agattatcaa     4260

caacttcaat gggattagga ttaagaccga ctatcacagc ctgctcgaca agaaagaaaa     4320

agagaggttt gaggcccgcc aaaactggac ctccattgag aatatcaaag aattaaaggc     4380

cggctatatt tcccaagtcg tccacaagat ctgcgagctg gtggagaaat atgacgccgt     4440

gattgcgctc gaagacttaa attctgggtt caagaactcc cgcgtgaagg tggaaaaaca     4500

ggtgtatcag aaattcgaga aaatgctgat cgacaaactc aattatatgg tggataagaa     4560

gtccaacccg tgtgccacag ggggcgcgct gaagggctat cagatcacca acaagttcga     4620

gagcttcaag agcatgagca cccagaacgg gtttattttc tacatcccgg cgtggctcac     4680

ctccaagatt gacccgagca ccggcttcgt gaacctcctg aagacaaagt atacctccat     4740

tgccgacagc aagaagttta tctcctcctt cgaccgcatt atgtatgtgc cggaggagga     4800

cctcttcgag ttcgccctcg actacaaaaa cttcagccgc acagatgcgg attacatcaa     4860

gaagtggaag ctgtactcct acgggaacag gatccgcatc ttcaggaatc caaaaaaaaa     4920

taacgtcttt gactgggagg aagtgtgcct gacatccgcc tacaaggaac tgttcaataa     4980

atacggcatc aattaccagc agggcgacat tcgcgccctc ctctgtgagc agtccgacaa     5040

agcgttttac tccagcttca tggccctcat gtccctgatg ctccaaatga ggaatagcat     5100

cacagggcgc accgacgtcg acttcctcat cagcccggtg aagaactccg acgggatctt     5160

ttacgactcc cgcaactatg aggcgcaaga gaatgcgatc ctcccgaaga acgccgatgc     5220

gaacggggcc tataatatcg ccaggaaagt gctctgggcc atcgggcagt tcaaaaaggc     5280

ggaggatgag aagctcgaca aggtgaaaat tgccatttcc aacaaggagt ggctggagta     5340

cgcgcagacc tccgtgaagc acggatctaa gaagagaaga attaaacaag attgacttaa     5400

ttaaagggct ctctgtcatg atttcatact ttcattattg agctctgtaa ttacaattat     5460

gaccatgaga acatctctta ttgtgtggcc ttttaattgc tgatgttagt actgaaccaa     5520

agcttatcgt gatgatgtaa aagcaataag tacttgtttg tagcttcttt gtgtctccct     5580

ttgggcttaa tacatctgtt tagtgttgtg gctttggcat agacttctct tggtaataat     5640

gccttgcaat gcaaaatttc aattatcaaa ttctattatg ttctcacctt atggtaacag     5700

cttaccctgt ggaagatgag attcttgagt tgagtcattg ccaatttttg gcattagctt     5760

ttgaattagt gaattttgac aaaaattacc gtgacactga ttttgttgaa gctcttaagt     5820

gtagttttta caaaatttca gtggctcgtt gtgattatgt caaactcacg gcgaatgtag     5880

ttcttacaga atttcagtgg ctcgggcccg gccgtgacgg ccacgagcga actcctgcag     5940

gcgataaaaa tgttttaaac gatatatatt ataaaaaaaa acgtttcaaa aataaataca     6000

aaaatgtttt taaatatata taatttaact cattaaagaa aataaaaatg caagtgcggt     6060

gacaagacaa gctaaaagtt gcaaaagaaa tggcagggct ataaggctca cctactcctg     6120

gatttaccaa attttggttc gtccctatac tcgaaaaata aaacaaaata aatttcagta     6180

tcttcgtttt tgtatgcttt gactgtgagg cgaggccaac tttcttcttc tgtctgagat     6240

gaattttgtt tgcctcctgt gaaggatgta tcattcaaag tgaatgtttt gcaactgcca     6300

gtagtcccac atcgaccaaa tattcttatt acagtgtgtt tatatagcac ctggagaagg     6360

aatgggttgt ttcaaagatt aaataatttc tactaagtgt agattgccgt taatttgaga     6420

gtccaagtaa tttctactaa gtgtagattt ttttttgcgg ccgcacaaca aacgcgccgg     6480

cgctctctta aggtagcaag gatccctgaa agcgacgttg gatgttaaca tctacaaatt     6540

gccttttctt atcgaccatg tacgtaagcg cttacgtttt tggtggaccc ttgaggaaac     6600

tggtagctgt tgtgggcctg tggtctcaag atggatcatt aatttccacc ttcacctacg     6660

atggggggca tcgcaccggt gagtaatatt gtacggctaa gagcgaattt ggcctgtaga     6720

cctcaattgc gagctttcta atttcaaact attcgggcct aacttttggt gtgatgatgc     6780

tgactggcag gatatatacc gttgtaattt gagctcgtgt gaataagtcg ctgtgtatgt     6840

ttgtttgatt gtttctgttg gagtgcagcc catttcaccg gacaagtcgg ctagattgat     6900

ttagccctga tgaactgccg aggggaagcc atcttgagcg cggaatggga atggatttcg     6960

ttgtacaacg agacgacaga acacccacgg gaccgagctt cgaagcttta acgcttgagt     7020

taagccgcgc cgcgaagcgg cgtcggcttg aacgaattgt tagacatcag aagaactcgt     7080

caagaaggcg atagaaggcg atgcgctgcg aatcgggagc ggcgataccg taaagcacga     7140

ggaagcggtc agcccattcg ccgccaagct cttcagcaat atcacgggta gccaacgcta     7200

tgtcctgata gcggtccgcc acacccagcc ggccacagtc gatgaatcca gaaaagcggc     7260

cattttccac catgatattc ggcaagcagg catcgccatg ggtcacgacg agatcctcgc     7320

cgtcgggcat gcgcgccttg agcctggcga acagttcggc tggcgcgagc ccctgatgct     7380

cttcgtccag atcatcctga tcgacaagac cggcttccat ccgagtacgt gctcgctcga     7440

tgcgatgttt cgcttggtgg tcgaatgggc aggtagccgg atcaagcgta tgcagccgcc     7500

gcattgcatc agccatgatg gatactttct cggcaggagc aaggtgagat gacaggagat     7560

cctgccccgg cacttcgccc aatagcagcc agtcccttcc cgcttcagtg acaacgtcga     7620

gcacagctgc gcaaggaacg cccgtcgtgg ccagccacga tagccgcgct gcctcgtcct     7680

gcagttcatt cagggcaccg gacaggtcgg tcttgacaaa aagaaccggg cgcccctgcg     7740

ctgacagccg gaacacggcg gcatcagagc agccgattgt ctgttgtgcc cagtcatagc     7800

cgaatagcct ctccacccaa gcggccggag aacctgcgtg caatccatct tgttcaatca     7860

tggctttgtt tctccttcaa tcattgacta ttgtcacgtt attctgaatc gacgagaact     7920

cacatcaatc tcaacaagca tctctgctcg cgaaattggt gttgtctcat taaaacgtga     7980

ccgtcaaagt ctattcacta ggacccaaat ctctccaggt cccgcaagct agcttcgccg     8040

cccacgtttc tctttcttct catattcaat tgtcaaaaaa cagacctcat gaccaaaatc     8100

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     8160

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     8220

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactt tttttccgaa ggtaactggc     8280

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     8340

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     8400

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     8460

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     8520

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     8580

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     8640

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     8700

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     8760

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct     8820

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct     8880

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg     8940

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc     9000

agtacaatct gctctgatgc cgcatagtta agccagtata caggctctcc ttcacgatca     9060

acgatcggca tggggccttc gtgcttgttg agtaatgtta tcgctcccat cagagcacgc     9120

ttggtactcc gggaatcgga tggtctgtcg atcatccaaa aaacgctcat gttttcaacc     9180

tattaggtct gtggtcagct gaccacagac catcctgctc catactcgct aattctagcc     9240

aaaccgcaac gtcccctgcc cgctagcctt caagagcgcc attatcatcg ggccaagtga     9300

aaacttcccg agctcgctcc gccgtgtcag atctcggaga tagcccccgg gcgaattgat     9360

gaagttcgct cgctccaaaa tgcacgccat cgctgctgcc gcattctccg gtcccattgc     9420

ctcacacgcg tcttggtaag ccgacgggct gacccccagc atagaccgaa ccaccaccgc     9480

agccgacatg aggtcacgcc agctagcaac cgcaccgctc ggcccataat tgccaatggt     9540

cgggcatgct ttcaggatca tcccgagggg gaacgctttt atcggctcgc tccttgcccg     9600

gtctatttca ctcggcttag cgccctgctc cttttcagag cgaggttcaa gttcattaac     9660

ggattcgggt tttgaattct gtatgtgctg ctcgctctgg gcagcattgg tgctattatt     9720

ttctgaattg tctctaattt ccaaccggtt gattatctct tcctggagca tccacatctc     9780

ttcgagaatt gactctacat cagcaagcgt cggggcgcgt ggaattctac ccacaagttc     9840

cacatagact tcctcgacag cttgccagtc gccctccgct ccctcttcca tagctgccgt     9900

aattagcttc cgaacgtccc gtcggcaaat cgtcagactt tctttggcca tcctgaatgc     9960

tgctcgatcg gccatcacct gctgtgccat catcgctagc tcttcggacc gcgcgagaag    10020

cggagacaaa tcgaagccaa acgcgcgctc gatctgacca gcgccatcct tacgagcgta    10080

acgctttccg ttggcgctat ccttccggac gatcaagcct gactccacga gcatggcgat    10140

gtgcctacgc aaagtcgcgc cagccatccc atgcgcccga agggcaagct gagcattcga    10200

cgggaagacg atcagctgtg cctcctgacg caactccgtt tccgggtgaa agctcaatag    10260

cgcatcaagg acggcaagac tgttggactg gattccaagt agttccatgg ccgcggacgc    10320

gtctctaaag accttccact tgtccgctgt cttgccttgt ttgatatcgg ccagcgccgt    10380

ctggcgccgc acaagcgcaa gcgtcattgg ccgccgcccg aatggcgtcg ttacacttcc    10440

tgtctgcatc atctttcacc tttcagcagg caaaggaaat cagctcacca aaacggcgct    10500

aaaaactctt gacgaggatt cgaggaaatg cgattctgtt cgcgctagag agacagaagg    10560

gcttccgcga cggcgacgtt gagggggctc ttttcttttg cggtttactc tccccgtttc    10620

cgttggttct cagcgtggta cgcttgatac agcgctggca catgatcgag cacgaaggtc    10680

gcaaaatcgg gcgtcgcctt cctgtcaatc gtgatttcca gtttggcctt gctctgcgtc    10740

acctgtgcaa ttctggtgcc gtctggggtg gccatgacct cgggaagtcc acgcgcaacc    10800

cgactgggct tcagactagc gatcaccgcc ttgaatcgtt ctgccgatgg cagcgcttga    10860

acttcctccg acatagcata tttagccacg tcggccggtg aagaaacttt ctcaatcagc    10920

tcggcaagtt gttgccaact cggccgtcca acaccaggag cggcaccaat agcatcggtc    10980

agttcagagg ggagggcgtc gacgagcaga agcatcttgg acaaattgct cttgtcgatc    11040

gacatcgcgg cgatgacaat ctctcgagaa aactgcctgt tcaggcgatg tgcgaagcgc    11100

gccttttcga tgaaggtaag atcttcgcgc tcattgtttt cctgaccctg tgctacgacc    11160

acttgctcgt ccgtcagttc gcgaacgacc gctctgaccg gaagtccgag ttctgaaacg    11220

gcgcgtagcc ggcggtggcc gaaggcaacc tgatatcggc ccggctggct cggatgcggt    11280

cgcacaagga ttgggacttg ctgtccttgt tcccggatcg aagtaaggag cccgtcaatg    11340

tcccctcgca tacgatcctg cacgaaagac ggttctattg acgaggcatc caactctatc    11400

actgcctgac cttcagcgag acgccgctcg atctcttcgg cacggctaag acgatcgttt    11460

tgctctcgca gtgcgttacc aatgttcgct gtgagcttcg ttgccggatc gcgctccttc    11520

cttgttacgc cgaggagcgg catggagcgg ttctttgccg tcctattgtc ggcgggcgac    11580

gtctcagggg cgtcagttga gacgccaagg atgtgcttcc ggctcatgtg ggcctacccc    11640

atgctttttt gatcagtgtt tcgatctcgt cgttgacggc gttcatcgcc tccaaggctc    11700

gatcataggt cgagcgcgtg aacaggccac gctccacttc gaatagagtc tggtttgtca    11760

ggccagcgtc cgaaaccgcg gtggttttaa gcatcggaaa attgaggaca ttttcgccaa    11820

aaatcgaccg cagataacct accatttggt tctgtggtcc gtcgctcggt tcgaaacggg    11880

ttatcagata gcgcatccaa ttaaacttga acttggcgcc agcattctcg atttcacgca    11940

aaaggttcga tgtcattgcc agaaactggt tcatcgacat cacatccagc atctgcggat    12000

ggaccgtgac aagaatggac gtcgccgcag tcaatgcgga tagcgtgaga tacccaagct    12060

ggggagggca gtcgatgacc acgacgtcat agttatccgc gatatcttca attacttggc    12120

tgatgcgacc ataaaagagc gtgtcgccct ctttgcggtt catcagcgcg cgtggcgtat    12180

cgtgttcaaa ctccatcagc tcaaggttac caggaatcag gtggaggtcg ggaatgtaag    12240

tccctcggac gactcgttcg attgccacct gctcatcatc ataccttata gcgccgtaga    12300

gcgtttcgtt cgggccaacg tccgtctccg gttggctccc aaagagtgca gaaaggctcg    12360

cttgaggatc gagatcaatg gccaagactc gatatccgcg catagcgagg tactgcgcca    12420

gatgcgcggc ggtggtggtc ttacccgacc cacctttgaa attcatcaca gagataacct    12480

gaagctgctc gccgcctcga cgatgtggca ggtagcgccg gttcccgcgg ccgacctgat    12540

ccatatactt ccgaatcaca tggatatctt caattgagaa cattcgcctg ccacccgggc    12600

tcatgctaac attcaactct ggcatctcag acgcggtctg ccgtaaatat gactcgccaa    12660

cgccgagcag cttggacgcc tccgatggcc cgaatgttcg aatgcccttc tcggaatgcg    12720

gcgggaaaac cttaagatga tgtgcttgaa gttggctcga gagggcatcg gcatgacgct    12780

ccatcaaggc cgtcaaccct acaactacag gcgctgcttt taggacagac ttcgccatct    12840

caaacccatt ccttgccagt ggcgatattt ttcgcgaaac tggaaaagtt ccgccgctgg    12900

caattagcgc cgattctgct gtttgggcaa gagcttttag gttaacagaa ggttaacgcc    12960

ctcaggtcga aaaactccac ccaactgtta tttgtattta tttccaatgc cttagagaga    13020

ttgccatttg aatatgttca tgtattgttt tagtgataat cctacaatcg taacccaaaa    13080

agaggtcgcc ctctgcgcgc cgtcgtccaa tataggcgaa gtcacccttg cgactcaggc    13140

ggattctacc ttgtacacgt gtcgagtgga aaagtcccat gtggatcact ccgttgcccc    13200

gtcgctcacc gtgttggggg gaaggtgcac atggctcagt tctcaatgga aattatctgc    13260

ctaaccggct cagttctgcg tagaaaccaa catgcaagct ccaccgggtg caaagcggca    13320

gcggcggcag gatatattca attgtaaatg gcttcatgtc cgggaaatct acatggatca    13380

gcaatgagta tgatggtcaa tatggagaaa aagaaagagt aattaccaat tttttttcaa    13440

ttcaaaaatg tagatgtccg cagcgttatt ataaaatgaa agtacatttt gataaaacga    13500

caaattacga tccgtcgtat ttataggcga aagcaataaa caaattattc taattcggaa    13560

atctttattt cgacgtgtct acattcacgt ccaaatgggg gcttagatga gaaacttcac    13620

gatcgatgcg gccctaggcg tacgataact tcgtataatg tatgctatac gaagttatca    13680

ctagtcaaca attggccaat ctttgttcta aattgctaat aaacgaccat ttccgtcaat    13740

tctccttggt tgcaacagtc tacccgtcaa atgtttacta atttataagt gtgaagtttg    13800

aattatgaaa gacgaaatcg tattaaaaat tcacaagaat aaacaactcc atagattttc    13860

aaaaaaacag tcacgagaaa aaaaccacag tccgtttgtc tgctcttcta gtttttatta    13920

tttttctatt aatagttttt tgttatttcg agaataaaat ttgaacgatg tccgaaccac    13980

aaaagccgag ccgataaatc ctaagccgag cctaacttta gccgtaacca tcagtcacgg    14040

ctcccgggct aattcatttg aaccgaatca taatcaacgg tttagatcaa actcaaaaca    14100

atctaacggc aacatagacg cgtcggtgag ctaaaaagag tgtgaaagcc aggtcaccat    14160

agcattgtct ctcccagatt ttttatttgg gaaataatag aagaaataga aaaaaataaa    14220

agagtgagaa aaatcgtaga gctatatatt cgcacatgta ctcgtttcgc tttccttagt    14280

gttagctgct gccgctgttg tttctcctcc atttctctat ctttctctct cgctgcttct    14340

cgaatcttct gtatcatctt cttcttcttc aaggtgagtc tctagatccg ttcgcttgat    14400

tttgctgctc gttagtcgtt attgttgatt ctctatgccg atttcgctag atctgtttag    14460

catgcgttgt ggttttatga gaaaatcttt gttttggggg ttgcttgtta tgtgattcga    14520

tccgtgcttg ttggatcgat ctgagctaat tcttaaggtt tatgtgttag atctatggag    14580

tttgaggatt cttctcgctt ctgtcgatct ctcgctgtta tttttgtttt tttcagtgaa    14640

gtgaagttgt ttagttcgaa atgacttcgt gtatgctcga ttgatctggt tttaatcttc    14700

gatctgttag gtgttgatgt ttacaagtga attctagtgt tttctcgttg agatctgtga    14760

agtttgaacc tagttttctc aataatcaac atatgaagcg atgtttgagt ttcaataaac    14820

gctgctaatc ttcgaaacta agttgtgatc tgattcgtgt ttacttcatg agcttatcca    14880

attcatttcg gtttcatttt actttttttt tagtgaacca tggcgcaagt tagcagaatc    14940

tgcaatggtg tgcagaaccc atctcttatc tccaatctct cgaaatccag tcaacgcaaa    15000

tctcccttat cggtttctct gaagacgcag cagcatccac gagcttatcc gatttcgtcg    15060

tcgtggggat tgaagaagag tgggatgacg ttaattggct ctgagcttcg tcctcttaag    15120

gtcatgtctt ctgtttccac ggcgtgcatg ggggaagcgg tgatcgccga agtatcgact    15180

caactatcag aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt gctggccgta    15240

catttgtacg gctccgcagt ggatggcggc ctgaagccac acagtgatat tgatttgctg    15300

gttacggtga ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa cgaccttttg    15360

gaaacttcgg cttcccctgg agagagcgag attctccgcg ctgtagaagt caccattgtt    15420

gtgcacgacg acatcattcc gtggcgttat ccagctaagc gcgaactgca atttggagaa    15480

tggcagcgca atgacattct tgcaggtatc ttcgagccag ccacgatcga cattgatctg    15540

gctatcttgc tgacaaaagc aagagaacat agcgttgcct tggtaggtcc agcggcggag    15600

gaactctttg atccggttcc tgaacaggat ctatttgagg cgctaaatga aaccttaacg    15660

ctatggaact cgccgcccga ctgggctggc gatgagcgaa atgtagtgct tacgttgtcc    15720

cgcatttggt acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc tgccgactgg    15780

gcaatggagc gcctgccggc ccagtatcag cccgtcatac ttgaagctag acaggcttat    15840

cttggacaag aagaagatcg cttggcctcg cgcgcagatc agttggaaga atttgtccac    15900

tacgtgaaag gcgagatcac caaggtagtc ggcaaataag gatcaattcc cgatcgttca    15960

aacatttggc aataaagttt cttaagattg aatcctgttg ccggtcttgc gatgattatc    16020

atataatttc tgttgaatta cgttaagcat gtaataatta acatgtaatg catgacgtta    16080

tttatgagat gggtttttat gattagagtc ccgcaattat acatttaata cgcgatagaa    16140

aacaaaatat agcgcgcaaa ctaggataaa ttatcgcgcg cggtgtcatc tatgttacta    16200

gatcggggat ccaacgttat aacttcgtat aatgtatgct atacgaagtt attaactata    16260

acggtcctaa ggtagcgact taggctgagc ccgggcaggc ctacccataa ta            16312


<210>  119
<211>  6973
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3030 Full Plasmid Sequence

<400>  119
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagactgtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt gacgcgttgc ggctgcatga      420

aatcctggcc ggtttgtctg atgccaagct ggcggcctgg ccggccagct tggccgctga      480

agaaaccgag cgccgccgtc taaaaaggtg atgtgtattt gagtaaaaca gcttgcgtca      540

tgcggtcgct gcgtatatga tgcgatgagt aaataaacaa atacgcaagg ggaacgcatg      600

aaggttatcg ctgtacttaa ccagaaaggc gggtcaggca agacgaccat cgcaacccat      660

ctagcccgcg ccctgcaact cgccggggcc gatgttctgt tagtcgattc cgatccccag      720

ggcagtgccc gcgattgggc ggccgtgcgg gaagatcaac cgctaaccgt tgtcggcatc      780

gaccgcccga cgattgaccg cgacgtgaag gccatcggcc ggcgcgactt cgtagtgatc      840

gacggagcgc cccaggcggc ggacttggct gtgtccgcga tcaaggcagc cgacttcgtg      900

ctgattccgg tgcagccaag cccttacgac atatgggcca ccgccgacct ggtggagctg      960

gttaagcagc gcattgaggt cacggatgga aggctacaag cggcctttgt cgtgtcgcgg     1020

gcgatcaaag gcacgcgcat cggcggtgag gttgccgagg cgctggccgg gtacgagctg     1080

cccattcttg agtcccgtat cacgcagcgc gtgagctacc caggcactgc cgccgccggc     1140

acaaccgttc ttgaatcaga acccgagggc gacgctgccc gcgaggtcca ggcgctggcc     1200

gctgaaatta aatcaaaact catttgagtt aatgaggtaa agagaaaatg agcaaaagca     1260

caaacacgct aagtgccggc cgtccgagcg cacgcagcag caaggctgca acgttggcca     1320

gcctggcaga cacgccagcc atgaagcggg tcaactttca gttgccggcg gaggatcaca     1380

ccaagctgaa gatgtacgcg gtacgccaag gcaagaccat taccgagctg ctatctgaat     1440

acatcgcgca gctaccagag taaatgagca aatgaataaa tgagtagatg aattttagcg     1500

gctaaaggag gcggcatgga aaatcaagaa caaccaggca ccgacgccgt ggaatgcccc     1560

atgtgtggag gaacgggcgg ttggccaggc gtaagcggct gggttgtctg ccggccctgc     1620

aatggcactg gaacccccaa gcccgaggaa tcggcgtgag cggtcgcaaa ccatccggcc     1680

cggtacaaat cggcgcggcg ctgggtgatg acctggtgga gaagttgaag gccgcgcagg     1740

ccgcccagcg gcaacgcatc gaggcagaag cacgccccgg tgaatcgtgg caagcggccg     1800

ctgatcgaat ccgcaaagaa tcccggcaac cgccggcagc cggtgcgccg tcgattagga     1860

agccgcccaa gggcgacgag caaccagatt ttttcgttcc gatgctctat gacgtgggca     1920

cccgcgatag tcgcagcatc atggacgtgg ccgttttccg tctgtcgaag cgtgaccgac     1980

gagctggcga ggtgatccgc tacgagcttc cagacgggca cgtagaggtt tccgcagggc     2040

cggccggcat ggccagtgtg tgggattacg acctggtact gatggcggtt tcccatctaa     2100

ccgaatccat gaaccgatac cgggaaggga agggagacaa gcccggccgc gtgttccgtc     2160

cacacgttgc ggacgtactc aagttctgcc ggcgagccga tggcggaaag cagaaagacg     2220

acctggtaga aacctgcatt cggttaaaca ccacgcacgt tgccatgcag cgtacgaaga     2280

aggccaagaa cggccgcctg gtgacggtat ccgagggtga agccttgatt agccgctaca     2340

agatcgtaaa gagcgaaacc gggcggccgg agtacatcga gatcgagcta gctgattgga     2400

tgtaccgcga gatcacagaa ggcaagaacc cggacgtgct gacggttcac cccgattact     2460

ttttgatcga tcccggcatc ggccgttttc tctaccgcct ggcacgccgc gccgcaggca     2520

aggcagaagc cagatggttg ttcaagacga tctacgaacg cagtggcagc gccggagagt     2580

tcaagaagtt ctgtttcacc gtgcgcaagc tgatcgggtc aaatgacctg ccggagtacg     2640

atttgaagga ggaggcgggg caggctggcc cgatcctagt catgcgctac cgcaacctga     2700

tcgagggcga agcatccgcc ggttcctaat gtacggagca gatgctaggg caaattgccc     2760

tagcagggga aaaaggtcga aaaggtctct ttcctgtgga tagcacgtac attgggaacc     2820

caaagccgta cattgggaac cggaacccgt acattgggaa cccaaagccg tacattggga     2880

accggtcaca catgtaagtg actgatataa aagagaaaaa aggcgatttt tccgcctaaa     2940

actctttaaa acttattaaa actcttaaaa cccgcctggc ctgtgcatat gctagtcatg     3000

ccccgcgccc accggaagga gctgactggg ttgaaggctc tcaagggcat cggtcgagat     3060

cccggtgcct aatgagtgag ctaacttaca ttaattgcgt tgcgccccgg gatgagatta     3120

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     3180

agtatatatg tgtaacattg gtctagtgat tggatccttg acagctagct cagtcctagg     3240

tactgtgcta gcgctagcaa agaggagaaa ggtaccatgc ccgatcgagc tcaagttatc     3300

attcgcattg tgccgggagg tggcaccaag acccttcaac aaattatcaa tcagttggag     3360

tatctatccc ggaagggcag gctggagctg cagcgttcag cccgacatct cgatattccc     3420

ctgccaccgg atcaaatcca cgaacttgcc cgaagctggg ttcaagagac tggaacttat     3480

gacgaaagtc agccagacga ggaaaggcaa caggagttga ccacccatat tattgtaagc     3540

ttccccgccg gtacaagcca ggtagcggct tatgcggcga gccgggagtg ggcagccgag     3600

atgtttgggt caggcgcagg ggggggccga tacaactatc ttacggcctt ccacatcgat     3660

cgcgaccacc cacatctgca tgtcgtcgtc aatcggcgcg aacttttagg acacggctgg     3720

ctgaagatat ctcggcgcca tccccaactg aattacgacg ccctgcgcat aaagatggcc     3780

gagatttcac ttcgtcatgg cattgccctc gatgcgagcc gacgagcaga acgtggcatc     3840

accgagcggc cgatcactta tgcccaatat cggcgccttg agcgggagca ggctcgccaa     3900

atccgtttcg aagacgcgga tttggaacag tcgtcgccgc aaggagatca tccagaattc     3960

agccaacctt tcgatacatc cccatttgaa gcatccgcgg gcggaccgga ggacatgcct     4020

cggcccaaca atcggcagaa tgagtcgcaa gttcatctcc aggagccagc tggtgtcagc     4080

aacgaagccg gtgtccttgt gcgggttgca ttggaaacgg agcgccttgc tcaaccattc     4140

gtttccgaaa ccattctcgc ggacgacata gggagcggct cttcgcgtgt tgccgagggc     4200

cgtgtggaga gcgcaaaccg cactcccgat attcctcgcg cagcaactga agctgccacg     4260

cacacgacac acgaccggca gcggcgtgca aagcgtcctc atgatgacga cggagggccg     4320

agtggagcaa aacgtgtgac attggaaggc atcgcggttg ggccccaggc gaacgccggc     4380

gaacaggatg gcagtagtgg ccccttagta cggcaagctg gaacgtcacg gccatctcca     4440

ccgacggcca cgacgcgggc cagcaccgca accgattcat tgtctgctac agcccacctc     4500

cagcaacgga gaggtgtcct ttcaaagcgt ccgcgtgaag atgatgatgg agaaccgagt     4560

gaacgcaaac gcgagagaga tgagcgcagc aaggacgggc gtgggggaaa taggagatag     4620

tctagaccag gcatcaaata aaacgaaagg ctcagtcgaa agactgggcc tttcgtttta     4680

tctgttgttt gtcggtgaac gctctctact agagtcacac tggctcacct tcgggtgggc     4740

ctttctgcgt ttatagtacg atatcccaat ggcgcgccga gcttggctcg agcatggtca     4800

tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga     4860

agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg     4920

cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc     4980

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctgtt ccgcttcctc gctcactgac     5040

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     5100

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     5160

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     5220

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     5280

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     5340

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     5400

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     5460

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     5520

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     5580

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga     5640

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     5700

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     5760

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     5820

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     5880

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     5940

taaacttggt ctgacagtta gaaaaactca tcgagcatca aatgaaactg caatttattc     6000

atatcaggat tatcaatacc atatttttga aaaagccgtt tctgtaatga aggagaaaac     6060

tcaccgaggc agttccatag gatggcaaga tcctggtatc ggtctgcgat tccgactcgt     6120

ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa taaggttatc aagtgagaaa     6180

tcaccatgag tgacgactga atccggtgag aatggcaaaa gtttatgcat ttctttccag     6240

acttgttcaa caggccagcc attacgctcg tcatcaaaat cactcgcatc aaccaaaccg     6300

ttattcattc gtgattgcgc ctgagcgaaa cgaaatacgc gatcgctgtt aaaaggacaa     6360

ttacaaacag gaatcgaatg caaccggcgc aggaacactg ccagcgcatc aacaatattt     6420

tcacctgaat caggatattc ttctaatacc tggaatgctg ttttcccagg gatcgcagtg     6480

gtgagtaacc atgcatcatc aggagtacgg ataaaatgct tgatggtcgg aagaggcata     6540

aattccgtca gccagtttag tctgaccatc tcatctgtaa catcattggc aacgctacct     6600

ttgccatgtt tcagaaacaa ctctggcgca tcgggcttcc catacaatcg atagattgtc     6660

gcacctgatt gcccgacatt atcgcgagcc catttatacc catataaatc agcatccatg     6720

ttggaattta atcgcggcct agagcaagac gtttcccgtt gaatatggct catactcttc     6780

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     6840

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     6900

cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg     6960

aggccctttt gtc                                                        6973


<210>  120
<211>  7378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3115 Full Plasmid Sequence

<400>  120
gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt       60

gcctaatgag tgagctaact tacattaatt gcgttgcgcc ccgggatgag attatcaaaa      120

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata      180

tatgtgtaac attggtctag tgattggatc cttgacagct agctcagtcc taggtactgt      240

gctagcgcta gcaaagagga gaaaggtacc atgcccgatc gagctcaagt tatcattcgc      300

attgtgccgg gaggtggcac caagaccctt caacaaatta tcaatcagtt ggagtatcta      360

tcccggaagg gcaggctgga gctgcagcgt tcagcccgac atctcgatat tcccctgcca      420

ccggatcaaa tccacgaact tgcccgaagc tgggttcaag agactggaac ttatgacgaa      480

agtcagccag acgaggaaag gcaacaggag ttgaccaccc atattattgt aagcttcccc      540

gccggtacaa gccaggtagc ggcttatgcg gcgagccggg agtgggcagc cgagatgttt      600

gggtcaggcg cagggggggg ccgatacaac tatcttacgg ccttccacat cgatcgcgac      660

cacccacatc tgcatgtcgt cgtcaatcgg cgcgaacttt taggacacgg ctggctgaag      720

atatctcggc gccatcccca actgaattac gacgccctgc gcataaagat ggccgagatt      780

tcacttcgtc atggcattgc cctcgatgcg agccgacgag cagaacgtgg catcaccgag      840

cggccgatca cttatgccca atatcggcgc cttgagcggg agcaggctcg ccaaatccgt      900

ttcgaagacg cggatttgga acagtcgtcg ccgcaaggag atcatccaga attcagccaa      960

cctttcgata catccccatt tgaagcatcc gcgggcggac cggaggacat gcctcggccc     1020

aacaatcggc agaatgagtc gcaagttcat ctccaggagc cagctggtgt cagcaacgaa     1080

gccggtgtcc ttgtgcgggt tgcattggaa acggagcgcc ttgctcaacc attcgtttcc     1140

gaaaccattc tcgcggacga catagggagc ggctcttcgc gtgttgccga gggccgtgtg     1200

gagagcgcaa accgcactcc cgatattcct cgcgcagcaa ctgaagctgc cacgcacacg     1260

acacacgacc ggcagcggcg tgcaaagcgt cctcatgatg acgacggagg gccgagtgga     1320

gcaaaacgtg tgacattgga aggcatcgcg gttgggcccc aggcgaacgc cggcgaacag     1380

gatggcagta gtggcccctt agtacggcaa gctggaacgt cacggccatc tccaccgacg     1440

gccacgacgc gggccagcac cgcaaccgat tcattgtctg ctacagccca cctccagcaa     1500

cggagaggtg tcctttcaaa gcgtccgcgt gaagatgatg atggagaacc gagtgaacgc     1560

aaacgcgaga gagatgagcg cagcaaggac gggcgtgggg gaaataggag aagcggtggc     1620

tcctcgggtg gcagcatgag cggatcaaaa aaaagaagga tcaagcaaga tgcggagtac     1680

gtgcgtgctt tgtttgattt caacggcaac gatgaagaag acctgccatt caaaaagggc     1740

gacatcctgc gtattcgtga taaaccggaa gagcagtggt ggaatgcaga ggacagcgaa     1800

ggtaagcgcg gtatgatccc ggttccgtat gtcgagaagt actccggtgg cagttccggt     1860

ggcagcagtg cgtcgttagc aagaggcggt ccaaatgcag tgggactcct aacgacgaac     1920

gaaagctttg agaaaaatat caatgaggtc tacaaccgta cgcgagccga gctagacgct     1980

tcttcacgtg acagaagtcg ctctggacta tcgcgataat ctagaccagg catcaaataa     2040

aacgaaaggc tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg     2100

ctctctacta gagtcacact ggctcacctt cgggtgggcc tttctgcgtt tatagtacga     2160

tatcccaatg gcgcgccgag cttggctcga gcatggtcat agctgtttcc tgtgtgaaat     2220

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg     2280

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag     2340

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     2400

ttgcgtattg ggcgctgttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg     2460

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg     2520

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     2580

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     2640

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     2700

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     2760

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg     2820

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     2880

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     2940

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     3000

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct     3060

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     3120

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     3180

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     3240

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     3300

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttag     3360

aaaaactcat cgagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca     3420

tatttttgaa aaagccgttt ctgtaatgaa ggagaaaact caccgaggca gttccatagg     3480

atggcaagat cctggtatcg gtctgcgatt ccgactcgtc caacatcaat acaacctatt     3540

aatttcccct cgtcaaaaat aaggttatca agtgagaaat caccatgagt gacgactgaa     3600

tccggtgaga atggcaaaag tttatgcatt tctttccaga cttgttcaac aggccagcca     3660

ttacgctcgt catcaaaatc actcgcatca accaaaccgt tattcattcg tgattgcgcc     3720

tgagcgaaac gaaatacgcg atcgctgtta aaaggacaat tacaaacagg aatcgaatgc     3780

aaccggcgca ggaacactgc cagcgcatca acaatatttt cacctgaatc aggatattct     3840

tctaatacct ggaatgctgt tttcccaggg atcgcagtgg tgagtaacca tgcatcatca     3900

ggagtacgga taaaatgctt gatggtcgga agaggcataa attccgtcag ccagtttagt     3960

ctgaccatct catctgtaac atcattggca acgctacctt tgccatgttt cagaaacaac     4020

tctggcgcat cgggcttccc atacaatcga tagattgtcg cacctgattg cccgacatta     4080

tcgcgagccc atttataccc atataaatca gcatccatgt tggaatttaa tcgcggccta     4140

gagcaagacg tttcccgttg aatatggctc atactcttcc tttttcaata ttattgaagc     4200

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     4260

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt     4320

attatcatga cattaaccta taaaaatagg cgtatcacga ggcccttttg tctcgcgcgt     4380

ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagactgt cacagcttgt     4440

ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg     4500

tgtcggggct ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatatg     4560

cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ccattcgcca     4620

ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag     4680

ctggcgaaag ggggatgtgc tgcaaggcga ttaagttggg taacgccagg gttttcccag     4740

tcacgacgtt gtaaaacgac ggccagtgaa ttgacgcgtt gcggctgcat gaaatcctgg     4800

ccggtttgtc tgatgccaag ctggcggcct ggccggccag cttggccgct gaagaaaccg     4860

agcgccgccg tctaaaaagg tgatgtgtat ttgagtaaaa cagcttgcgt catgcggtcg     4920

ctgcgtatat gatgcgatga gtaaataaac aaatacgcaa ggggaacgca tgaaggttat     4980

cgctgtactt aaccagaaag gcgggtcagg caagacgacc atcgcaaccc atctagcccg     5040

cgccctgcaa ctcgccgggg ccgatgttct gttagtcgat tccgatcccc agggcagtgc     5100

ccgcgattgg gcggccgtgc gggaagatca accgctaacc gttgtcggca tcgaccgccc     5160

gacgattgac cgcgacgtga aggccatcgg ccggcgcgac ttcgtagtga tcgacggagc     5220

gccccaggcg gcggacttgg ctgtgtccgc gatcaaggca gccgacttcg tgctgattcc     5280

ggtgcagcca agcccttacg acatatgggc caccgccgac ctggtggagc tggttaagca     5340

gcgcattgag gtcacggatg gaaggctaca agcggccttt gtcgtgtcgc gggcgatcaa     5400

aggcacgcgc atcggcggtg aggttgccga ggcgctggcc gggtacgagc tgcccattct     5460

tgagtcccgt atcacgcagc gcgtgagcta cccaggcact gccgccgccg gcacaaccgt     5520

tcttgaatca gaacccgagg gcgacgctgc ccgcgaggtc caggcgctgg ccgctgaaat     5580

taaatcaaaa ctcatttgag ttaatgaggt aaagagaaaa tgagcaaaag cacaaacacg     5640

ctaagtgccg gccgtccgag cgcacgcagc agcaaggctg caacgttggc cagcctggca     5700

gacacgccag ccatgaagcg ggtcaacttt cagttgccgg cggaggatca caccaagctg     5760

aagatgtacg cggtacgcca aggcaagacc attaccgagc tgctatctga atacatcgcg     5820

cagctaccag agtaaatgag caaatgaata aatgagtaga tgaattttag cggctaaagg     5880

aggcggcatg gaaaatcaag aacaaccagg caccgacgcc gtggaatgcc ccatgtgtgg     5940

aggaacgggc ggttggccag gcgtaagcgg ctgggttgtc tgccggccct gcaatggcac     6000

tggaaccccc aagcccgagg aatcggcgtg agcggtcgca aaccatccgg cccggtacaa     6060

atcggcgcgg cgctgggtga tgacctggtg gagaagttga aggccgcgca ggccgcccag     6120

cggcaacgca tcgaggcaga agcacgcccc ggtgaatcgt ggcaagcggc cgctgatcga     6180

atccgcaaag aatcccggca accgccggca gccggtgcgc cgtcgattag gaagccgccc     6240

aagggcgacg agcaaccaga ttttttcgtt ccgatgctct atgacgtggg cacccgcgat     6300

agtcgcagca tcatggacgt ggccgttttc cgtctgtcga agcgtgaccg acgagctggc     6360

gaggtgatcc gctacgagct tccagacggg cacgtagagg tttccgcagg gccggccggc     6420

atggccagtg tgtgggatta cgacctggta ctgatggcgg tttcccatct aaccgaatcc     6480

atgaaccgat accgggaagg gaagggagac aagcccggcc gcgtgttccg tccacacgtt     6540

gcggacgtac tcaagttctg ccggcgagcc gatggcggaa agcagaaaga cgacctggta     6600

gaaacctgca ttcggttaaa caccacgcac gttgccatgc agcgtacgaa gaaggccaag     6660

aacggccgcc tggtgacggt atccgagggt gaagccttga ttagccgcta caagatcgta     6720

aagagcgaaa ccgggcggcc ggagtacatc gagatcgagc tagctgattg gatgtaccgc     6780

gagatcacag aaggcaagaa cccggacgtg ctgacggttc accccgatta ctttttgatc     6840

gatcccggca tcggccgttt tctctaccgc ctggcacgcc gcgccgcagg caaggcagaa     6900

gccagatggt tgttcaagac gatctacgaa cgcagtggca gcgccggaga gttcaagaag     6960

ttctgtttca ccgtgcgcaa gctgatcggg tcaaatgacc tgccggagta cgatttgaag     7020

gaggaggcgg ggcaggctgg cccgatccta gtcatgcgct accgcaacct gatcgagggc     7080

gaagcatccg ccggttccta atgtacggag cagatgctag ggcaaattgc cctagcaggg     7140

gaaaaaggtc gaaaaggtct ctttcctgtg gatagcacgt acattgggaa cccaaagccg     7200

tacattggga accggaaccc gtacattggg aacccaaagc cgtacattgg gaaccggtca     7260

cacatgtaag tgactgatat aaaagagaaa aaaggcgatt tttccgccta aaactcttta     7320

aaacttatta aaactcttaa aacccgcctg gcctgtgcat atgctagtca tgccccgc       7378


<210>  121
<211>  7234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3122 Full Plasmid Sequence

<400>  121
accggaagga gctgactggg ttgaaggctc tcaagggcat cggtcgagat cccggtgcct       60

aatgagtgag ctaacttaca ttaattgcgt tgcgccccgg gatgagatta tcaaaaagga      120

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg      180

tgtaacattg gtctagtgat tggatccttg acagctagct cagtcctagg tactgtgcta      240

gcgctagcaa agaggagaaa ggtaccatgc ccgatcgagc tcaagttatc attcgcattg      300

tgccgggagg tggcaccaag acccttcaac aaattatcaa tcagttggag tatctatccc      360

ggaagggcag gctggagctg cagcgttcag cccgacatct cgatattccc ctgccaccgg      420

atcaaatcca cgaacttgcc cgaagctggg ttcaagagac tggaacttat gacgaaagtc      480

agccagacga ggaaaggcaa caggagttga ccacccatat tattgtaagc ttccccgccg      540

gtacaagcca ggtagcggct tatgcggcga gccgggagtg ggcagccgag atgtttgggt      600

caggcgcagg ggggggccga tacaactatc ttacggcctt ccacatcgat cgcgaccacc      660

cacatctgca tgtcgtcgtc aatcggcgcg aacttttagg acacggctgg ctgaagatat      720

ctcggcgcca tccccaactg aattacgacg ccctgcgcat aaagatggcc gagatttcac      780

ttcgtcatgg cattgccctc gatgcgagcc gacgagcaga acgtggcatc accgagcggc      840

cgatcactta tgcccaatat cggcgccttg agcgggagca ggctcgccaa atccgtttcg      900

aagacgcgga tttggaacag tcgtcgccgc aaggagatca tccagaattc agccaacctt      960

tcgatacatc cccatttgaa gcatccgcgg gcggaccgga ggacatgcct cggcccaaca     1020

atcggcagaa tgagtcgcaa gttcatctcc aggagccagc tggtgtcagc aacgaagccg     1080

gtgtccttgt gcgggttgca ttggaaacgg agcgccttgc tcaaccattc gtttccgaaa     1140

ccattctcgc ggacgacata gggagcggct cttcgcgtgt tgccgagggc cgtgtggaga     1200

gcgcaaaccg cactcccgat attcctcgcg cagcaactga agctgccacg cacacgacac     1260

acgaccggca gcggcgtgca aagcgtcctc atgatgacga cggagggccg agtggagcaa     1320

aacgtgtgac attggaaggc atcgcggttg ggccccaggc gaacgccggc gaacaggatg     1380

gcagtagtgg gggctcctcg ggtggcagca tgagcggatc aaaaaaaaga aggatcaagc     1440

aagatgcgga gtacgtgcgt gctttgtttg atttcaacgg caacgatgaa gaagacctgc     1500

cattcaaaaa gggcgacatc ctgcgtattc gtgataaacc ggaagagcag tggtggaatg     1560

cagaggacag cgaaggtaag cgcggtatga tcccggttcc gtatgtcgag aagtactccg     1620

gtagtggggg gtcctctggt ggaagtagtg gccccttagt acggcaagct ggaacgtcac     1680

ggccatctcc accgacggcc acgacgcggg ccagcaccgc aaccgattca ttgtctgcta     1740

cagcccacct ccagcaacgg agaggtgtcc tttcaaagcg tccgcgtgaa gatgatgatg     1800

gagaaccgag tgaacgcaaa cgcgagagag atgagcgcag caaggacggg cgtgggggaa     1860

ataggagata gtctagacca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc     1920

ctttcgtttt atctgttgtt tgtcggtgaa cgctctctac tagagtcaca ctggctcacc     1980

ttcgggtggg cctttctgcg tttatagtac gatatcccaa tggcgcgccg agcttggctc     2040

gagcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca     2100

tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat     2160

taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt     2220

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct     2280

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     2340

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     2400

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     2460

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     2520

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     2580

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     2640

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     2700

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     2760

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     2820

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     2880

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     2940

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     3000

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     3060

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     3120

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     3180

gtatatatga gtaaacttgg tctgacagtt agaaaaactc atcgagcatc aaatgaaact     3240

gcaatttatt catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg     3300

aaggagaaaa ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga     3360

ttccgactcg tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat     3420

caagtgagaa atcaccatga gtgacgactg aatccggtga gaatggcaaa agtttatgca     3480

tttctttcca gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat     3540

caaccaaacc gttattcatt cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt     3600

taaaaggaca attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat     3660

caacaatatt ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccag     3720

ggatcgcagt ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg     3780

gaagaggcat aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg     3840

caacgctacc tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc     3900

gatagattgt cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat     3960

cagcatccat gttggaattt aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc     4020

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg     4080

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     4140

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata     4200

ggcgtatcac gaggcccttt tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac     4260

acatgcagct cccggagact gtcacagctt gtctgtaagc ggatgccggg agcagacaag     4320

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat     4380

cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa     4440

ggagaaaata ccgcatcagg cgccattcgc cattcaggct gcgcaactgt tgggaagggc     4500

gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc     4560

gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg     4620

aattgacgcg ttgcggctgc atgaaatcct ggccggtttg tctgatgcca agctggcggc     4680

ctggccggcc agcttggccg ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt     4740

atttgagtaa aacagcttgc gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa     4800

acaaatacgc aaggggaacg catgaaggtt atcgctgtac ttaaccagaa aggcgggtca     4860

ggcaagacga ccatcgcaac ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt     4920

ctgttagtcg attccgatcc ccagggcagt gcccgcgatt gggcggccgt gcgggaagat     4980

caaccgctaa ccgttgtcgg catcgaccgc ccgacgattg accgcgacgt gaaggccatc     5040

ggccggcgcg acttcgtagt gatcgacgga gcgccccagg cggcggactt ggctgtgtcc     5100

gcgatcaagg cagccgactt cgtgctgatt ccggtgcagc caagccctta cgacatatgg     5160

gccaccgccg acctggtgga gctggttaag cagcgcattg aggtcacgga tggaaggcta     5220

caagcggcct ttgtcgtgtc gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc     5280

gaggcgctgg ccgggtacga gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc     5340

tacccaggca ctgccgccgc cggcacaacc gttcttgaat cagaacccga gggcgacgct     5400

gcccgcgagg tccaggcgct ggccgctgaa attaaatcaa aactcatttg agttaatgag     5460

gtaaagagaa aatgagcaaa agcacaaaca cgctaagtgc cggccgtccg agcgcacgca     5520

gcagcaaggc tgcaacgttg gccagcctgg cagacacgcc agccatgaag cgggtcaact     5580

ttcagttgcc ggcggaggat cacaccaagc tgaagatgta cgcggtacgc caaggcaaga     5640

ccattaccga gctgctatct gaatacatcg cgcagctacc agagtaaatg agcaaatgaa     5700

taaatgagta gatgaatttt agcggctaaa ggaggcggca tggaaaatca agaacaacca     5760

ggcaccgacg ccgtggaatg ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc     5820

ggctgggttg tctgccggcc ctgcaatggc actggaaccc ccaagcccga ggaatcggcg     5880

tgagcggtcg caaaccatcc ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg     5940

tggagaagtt gaaggccgcg caggccgccc agcggcaacg catcgaggca gaagcacgcc     6000

ccggtgaatc gtggcaagcg gccgctgatc gaatccgcaa agaatcccgg caaccgccgg     6060

cagccggtgc gccgtcgatt aggaagccgc ccaagggcga cgagcaacca gattttttcg     6120

ttccgatgct ctatgacgtg ggcacccgcg atagtcgcag catcatggac gtggccgttt     6180

tccgtctgtc gaagcgtgac cgacgagctg gcgaggtgat ccgctacgag cttccagacg     6240

ggcacgtaga ggtttccgca gggccggccg gcatggccag tgtgtgggat tacgacctgg     6300

tactgatggc ggtttcccat ctaaccgaat ccatgaaccg ataccgggaa gggaagggag     6360

acaagcccgg ccgcgtgttc cgtccacacg ttgcggacgt actcaagttc tgccggcgag     6420

ccgatggcgg aaagcagaaa gacgacctgg tagaaacctg cattcggtta aacaccacgc     6480

acgttgccat gcagcgtacg aagaaggcca agaacggccg cctggtgacg gtatccgagg     6540

gtgaagcctt gattagccgc tacaagatcg taaagagcga aaccgggcgg ccggagtaca     6600

tcgagatcga gctagctgat tggatgtacc gcgagatcac agaaggcaag aacccggacg     6660

tgctgacggt tcaccccgat tactttttga tcgatcccgg catcggccgt tttctctacc     6720

gcctggcacg ccgcgccgca ggcaaggcag aagccagatg gttgttcaag acgatctacg     6780

aacgcagtgg cagcgccgga gagttcaaga agttctgttt caccgtgcgc aagctgatcg     6840

ggtcaaatga cctgccggag tacgatttga aggaggaggc ggggcaggct ggcccgatcc     6900

tagtcatgcg ctaccgcaac ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg     6960

agcagatgct agggcaaatt gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg     7020

tggatagcac gtacattggg aacccaaagc cgtacattgg gaaccggaac ccgtacattg     7080

ggaacccaaa gccgtacatt gggaaccggt cacacatgta agtgactgat ataaaagaga     7140

aaaaaggcga tttttccgcc taaaactctt taaaacttat taaaactctt aaaacccgcc     7200

tggcctgtgc atatgctagt catgccccgc gccc                                 7234


<210>  122
<211>  7309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3109 Full Plasmid Sequence

<400>  122
cgcccaccgg aaggagctga ctgggttgaa ggctctcaag ggcatcggtc gagatcccgg       60

tgcctaatga gtgagctaac ttacattaat tgcgttgcgc cccgggatga gattatcaaa      120

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat      180

atatgtgtaa cattggtcta gtgattggat ccttgacagc tagctcagtc ctaggtactg      240

tgctagcgct agcaaagagg agaaaggtac catgagcgga tcaaaaaaaa gaaggatcaa      300

gcaagatccg ccgccagcgc tgccgcccaa gcgccgtcgc tccggcggta gcagcggtgg      360

ttccccgccg ccggctctgc cgccgaagcg ccgtagaagc ggcggttcaa gcggtggctc      420

tccgccaccg gcactgcctc cgaaacgtcg tcgttctggc ggtagcagcg gtggctcgcc      480

gccgccggcg ttgccgccga aacgccgtcg ttccggtgga agttccggag gttcaagcgg      540

gtctgaaacg ccgggcacca gcgagtcggc gaccccggaa agcagcggtg gttcttccgg      600

cggtagcatg cccgatcgag ctcaagttat cattcgcatt gtgccgggag gtggcaccaa      660

gacccttcaa caaattatca atcagttgga gtatctatcc cggaagggca ggctggagct      720

gcagcgttca gcccgacatc tcgatattcc cctgccaccg gatcaaatcc acgaacttgc      780

ccgaagctgg gttcaagaga ctggaactta tgacgaaagt cagccagacg aggaaaggca      840

acaggagttg accacccata ttattgtaag cttccccgcc ggtacaagcc aggtagcggc      900

ttatgcggcg agccgggagt gggcagccga gatgtttggg tcaggcgcag gggggggccg      960

atacaactat cttacggcct tccacatcga tcgcgaccac ccacatctgc atgtcgtcgt     1020

caatcggcgc gaacttttag gacacggctg gctgaagata tctcggcgcc atccccaact     1080

gaattacgac gccctgcgca taaagatggc cgagatttca cttcgtcatg gcattgccct     1140

cgatgcgagc cgacgagcag aacgtggcat caccgagcgg ccgatcactt atgcccaata     1200

tcggcgcctt gagcgggagc aggctcgcca aatccgtttc gaagacgcgg atttggaaca     1260

gtcgtcgccg caaggagatc atccagaatt cagccaacct ttcgatacat ccccatttga     1320

agcatccgcg ggcggaccgg aggacatgcc tcggcccaac aatcggcaga atgagtcgca     1380

agttcatctc caggagccag ctggtgtcag caacgaagcc ggtgtccttg tgcgggttgc     1440

attggaaacg gagcgccttg ctcaaccatt cgtttccgaa accattctcg cggacgacat     1500

agggagcggc tcttcgcgtg ttgccgaggg ccgtgtggag agcgcaaacc gcactcccga     1560

tattcctcgc gcagcaactg aagctgccac gcacacgaca cacgaccggc agcggcgtgc     1620

aaagcgtcct catgatgacg acggagggcc gagtggagca aaacgtgtga cattggaagg     1680

catcgcggtt gggccccagg cgaacgccgg cgaacaggat ggcagtagtg gccccttagt     1740

acggcaagct ggaacgtcac ggccatctcc accgacggcc acgacgcggg ccagcaccgc     1800

aaccgattca ttgtctgcta cagcccacct ccagcaacgg agaggtgtcc tttcaaagcg     1860

tccgcgtgaa gatgatgatg gagaaccgag tgaacgcaaa cgcgagagag atgagcgcag     1920

caaggacggg cgtgggggaa ataggagata gtctagacca ggcatcaaat aaaacgaaag     1980

gctcagtcga aagactgggc ctttcgtttt atctgttgtt tgtcggtgaa cgctctctac     2040

tagagtcaca ctggctcacc ttcgggtggg cctttctgcg tttatagtac gatatcccaa     2100

tggcgcgccg agcttggctc gagcatggtc atagctgttt cctgtgtgaa attgttatcc     2160

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta     2220

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     2280

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     2340

tgggcgctgt tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     2400

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     2460

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     2520

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     2580

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     2640

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     2700

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     2760

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     2820

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     2880

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     2940

gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa     3000

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     3060

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     3120

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     3180

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     3240

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt agaaaaactc     3300

atcgagcatc aaatgaaact gcaatttatt catatcagga ttatcaatac catatttttg     3360

aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg cagttccata ggatggcaag     3420

atcctggtat cggtctgcga ttccgactcg tccaacatca atacaaccta ttaatttccc     3480

ctcgtcaaaa ataaggttat caagtgagaa atcaccatga gtgacgactg aatccggtga     3540

gaatggcaaa agtttatgca tttctttcca gacttgttca acaggccagc cattacgctc     3600

gtcatcaaaa tcactcgcat caaccaaacc gttattcatt cgtgattgcg cctgagcgaa     3660

acgaaatacg cgatcgctgt taaaaggaca attacaaaca ggaatcgaat gcaaccggcg     3720

caggaacact gccagcgcat caacaatatt ttcacctgaa tcaggatatt cttctaatac     3780

ctggaatgct gttttcccag ggatcgcagt ggtgagtaac catgcatcat caggagtacg     3840

gataaaatgc ttgatggtcg gaagaggcat aaattccgtc agccagttta gtctgaccat     3900

ctcatctgta acatcattgg caacgctacc tttgccatgt ttcagaaaca actctggcgc     3960

atcgggcttc ccatacaatc gatagattgt cgcacctgat tgcccgacat tatcgcgagc     4020

ccatttatac ccatataaat cagcatccat gttggaattt aatcgcggcc tagagcaaga     4080

cgtttcccgt tgaatatggc tcatactctt cctttttcaa tattattgaa gcatttatca     4140

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     4200

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat     4260

gacattaacc tataaaaata ggcgtatcac gaggcccttt tgtctcgcgc gtttcggtga     4320

tgacggtgaa aacctctgac acatgcagct cccggagact gtcacagctt gtctgtaagc     4380

ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg     4440

ctggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata tgcggtgtga     4500

aataccgcac agatgcgtaa ggagaaaata ccgcatcagg cgccattcgc cattcaggct     4560

gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa     4620

agggggatgt gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg     4680

ttgtaaaacg acggccagtg aattgacgcg ttgcggctgc atgaaatcct ggccggtttg     4740

tctgatgcca agctggcggc ctggccggcc agcttggccg ctgaagaaac cgagcgccgc     4800

cgtctaaaaa ggtgatgtgt atttgagtaa aacagcttgc gtcatgcggt cgctgcgtat     4860

atgatgcgat gagtaaataa acaaatacgc aaggggaacg catgaaggtt atcgctgtac     4920

ttaaccagaa aggcgggtca ggcaagacga ccatcgcaac ccatctagcc cgcgccctgc     4980

aactcgccgg ggccgatgtt ctgttagtcg attccgatcc ccagggcagt gcccgcgatt     5040

gggcggccgt gcgggaagat caaccgctaa ccgttgtcgg catcgaccgc ccgacgattg     5100

accgcgacgt gaaggccatc ggccggcgcg acttcgtagt gatcgacgga gcgccccagg     5160

cggcggactt ggctgtgtcc gcgatcaagg cagccgactt cgtgctgatt ccggtgcagc     5220

caagccctta cgacatatgg gccaccgccg acctggtgga gctggttaag cagcgcattg     5280

aggtcacgga tggaaggcta caagcggcct ttgtcgtgtc gcgggcgatc aaaggcacgc     5340

gcatcggcgg tgaggttgcc gaggcgctgg ccgggtacga gctgcccatt cttgagtccc     5400

gtatcacgca gcgcgtgagc tacccaggca ctgccgccgc cggcacaacc gttcttgaat     5460

cagaacccga gggcgacgct gcccgcgagg tccaggcgct ggccgctgaa attaaatcaa     5520

aactcatttg agttaatgag gtaaagagaa aatgagcaaa agcacaaaca cgctaagtgc     5580

cggccgtccg agcgcacgca gcagcaaggc tgcaacgttg gccagcctgg cagacacgcc     5640

agccatgaag cgggtcaact ttcagttgcc ggcggaggat cacaccaagc tgaagatgta     5700

cgcggtacgc caaggcaaga ccattaccga gctgctatct gaatacatcg cgcagctacc     5760

agagtaaatg agcaaatgaa taaatgagta gatgaatttt agcggctaaa ggaggcggca     5820

tggaaaatca agaacaacca ggcaccgacg ccgtggaatg ccccatgtgt ggaggaacgg     5880

gcggttggcc aggcgtaagc ggctgggttg tctgccggcc ctgcaatggc actggaaccc     5940

ccaagcccga ggaatcggcg tgagcggtcg caaaccatcc ggcccggtac aaatcggcgc     6000

ggcgctgggt gatgacctgg tggagaagtt gaaggccgcg caggccgccc agcggcaacg     6060

catcgaggca gaagcacgcc ccggtgaatc gtggcaagcg gccgctgatc gaatccgcaa     6120

agaatcccgg caaccgccgg cagccggtgc gccgtcgatt aggaagccgc ccaagggcga     6180

cgagcaacca gattttttcg ttccgatgct ctatgacgtg ggcacccgcg atagtcgcag     6240

catcatggac gtggccgttt tccgtctgtc gaagcgtgac cgacgagctg gcgaggtgat     6300

ccgctacgag cttccagacg ggcacgtaga ggtttccgca gggccggccg gcatggccag     6360

tgtgtgggat tacgacctgg tactgatggc ggtttcccat ctaaccgaat ccatgaaccg     6420

ataccgggaa gggaagggag acaagcccgg ccgcgtgttc cgtccacacg ttgcggacgt     6480

actcaagttc tgccggcgag ccgatggcgg aaagcagaaa gacgacctgg tagaaacctg     6540

cattcggtta aacaccacgc acgttgccat gcagcgtacg aagaaggcca agaacggccg     6600

cctggtgacg gtatccgagg gtgaagcctt gattagccgc tacaagatcg taaagagcga     6660

aaccgggcgg ccggagtaca tcgagatcga gctagctgat tggatgtacc gcgagatcac     6720

agaaggcaag aacccggacg tgctgacggt tcaccccgat tactttttga tcgatcccgg     6780

catcggccgt tttctctacc gcctggcacg ccgcgccgca ggcaaggcag aagccagatg     6840

gttgttcaag acgatctacg aacgcagtgg cagcgccgga gagttcaaga agttctgttt     6900

caccgtgcgc aagctgatcg ggtcaaatga cctgccggag tacgatttga aggaggaggc     6960

ggggcaggct ggcccgatcc tagtcatgcg ctaccgcaac ctgatcgagg gcgaagcatc     7020

cgccggttcc taatgtacgg agcagatgct agggcaaatt gccctagcag gggaaaaagg     7080

tcgaaaaggt ctctttcctg tggatagcac gtacattggg aacccaaagc cgtacattgg     7140

gaaccggaac ccgtacattg ggaacccaaa gccgtacatt gggaaccggt cacacatgta     7200

agtgactgat ataaaagaga aaaaaggcga tttttccgcc taaaactctt taaaacttat     7260

taaaactctt aaaacccgcc tggcctgtgc atatgctagt catgccccg                 7309


<210>  123
<211>  8158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3103 Full Plasmid Sequence

<400>  123
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta       60

atgagtgagc taacttacat taattgcgtt gcgccccggg atgagattat caaaaaggat      120

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatgt      180

gtaacattgg tctagtgatt ggatccttga cagctagctc agtcctaggt actgtgctag      240

cgctagcaaa gaggagaaag gtaccatgag cggatcaaag aaaagaagga tcaagcaaga      300

tgaggaattg ctgagtaaaa actaccatct tgagaacgaa gttgcccgtc tgaagaaggg      360

tagcggttcg ggcggtagcg gttccggagg tagcggcagc ggctcgggtg gtagcggttc      420

aggtggctca ggcagtggtg aagaattgct gagcaaaaat tatcacctgg agaatgaagt      480

tgcgcgtctg aagaaaggca gcggctccgg tggttctggc tcgggcggtt caggtagtgg      540

ttccggtggc tccggcagcg gtggttctgg ctccggtgaa gagttgttgt ccaagaatta      600

tcatctggaa aacgaagtgg caagactcaa gaagggttcg ggttcgggcg gcagcggaag      660

tggtggtagc ggaagcggca gcggcggctc cggctccggt ggctccggca gcggtgagga      720

gctgctgagc aagaactacc acttggagaa cgaagtggca cgcctgaaga aaggtagcgg      780

tagcggcggt tctgggagcg gtggctccgg aagcggcagc ggcggttcgg gttctggtgg      840

cagcggtagc ggcgaagagc tgcttagcaa aaattatcac cttgagaacg aggtcgctcg      900

cctgaaaaaa ggttccggca gcggcggtag cggtagcggt ggcagcggta gcggcagcgg      960

tggctcgggg tccggtggta gcggctccgg tgaagaattg ttgtccaaaa actaccacct     1020

ggagaatgaa gtggcgcgtc tgaaaaaggg tagcggcagc ggtggtagcg gctctggagg     1080

tagcggctcc ggtagtggcg gtagcgggtc tggcggctct ggttcaggcg aagaactgct     1140

cagcaagaat taccatttgg agaacgaggt tgcgcgcctg aaaaagggct ctggtagcgg     1200

cggttctggc tctggtggca gcgggagcgg ctccggtggc agcggctctg gaggttccgg     1260

ttcgggtgag gagctgctga gcaagaacta ccacctggaa aacgaggtgg cgcgtctgaa     1320

aaaaggcagc aagaaacgtc gtatcaaaca ggactccggt ggaagttccg gaggttcaag     1380

cgggtctgaa acgccgggca ccagcgagtc ggcgaccccg gaaagcagcg gtggttcttc     1440

cggcggtagc atgcccgatc gagctcaagt tatcattcgc attgtgccgg gaggtggcac     1500

caagaccctt caacaaatta tcaatcagtt ggagtatcta tcccggaagg gcaggctgga     1560

gctgcagcgt tcagcccgac atctcgatat tcccctgcca ccggatcaaa tccacgaact     1620

tgcccgaagc tgggttcaag agactggaac ttatgacgaa agtcagccag acgaggaaag     1680

gcaacaggag ttgaccaccc atattattgt aagcttcccc gccggtacaa gccaggtagc     1740

ggcttatgcg gcgagccggg agtgggcagc cgagatgttt gggtcaggcg cagggggggg     1800

ccgatacaac tatcttacgg ccttccacat cgatcgcgac cacccacatc tgcatgtcgt     1860

cgtcaatcgg cgcgaacttt taggacacgg ctggctgaag atatctcggc gccatcccca     1920

actgaattac gacgccctgc gcataaagat ggccgagatt tcacttcgtc atggcattgc     1980

cctcgatgcg agccgacgag cagaacgtgg catcaccgag cggccgatca cttatgccca     2040

atatcggcgc cttgagcggg agcaggctcg ccaaatccgt ttcgaagacg cggatttgga     2100

acagtcgtcg ccgcaaggag atcatccaga attcagccaa cctttcgata catccccatt     2160

tgaagcatcc gcgggcggac cggaggacat gcctcggccc aacaatcggc agaatgagtc     2220

gcaagttcat ctccaggagc cagctggtgt cagcaacgaa gccggtgtcc ttgtgcgggt     2280

tgcattggaa acggagcgcc ttgctcaacc attcgtttcc gaaaccattc tcgcggacga     2340

catagggagc ggctcttcgc gtgttgccga gggccgtgtg gagagcgcaa accgcactcc     2400

cgatattcct cgcgcagcaa ctgaagctgc cacgcacacg acacacgacc ggcagcggcg     2460

tgcaaagcgt cctcatgatg acgacggagg gccgagtgga gcaaaacgtg tgacattgga     2520

aggcatcgcg gttgggcccc aggcgaacgc cggcgaacag gatggcagta gtggcccctt     2580

agtacggcaa gctggaacgt cacggccatc tccaccgacg gccacgacgc gggccagcac     2640

cgcaaccgat tcattgtctg ctacagccca cctccagcaa cggagaggtg tcctttcaaa     2700

gcgtccgcgt gaagatgatg atggagaacc gagtgaacgc aaacgcgaga gagatgagcg     2760

cagcaaggac gggcgtgggg gaaataggag atagtctaga ccaggcatca aataaaacga     2820

aaggctcagt cgaaagactg ggcctttcgt tttatctgtt gtttgtcggt gaacgctctc     2880

tactagagtc acactggctc accttcgggt gggcctttct gcgtttatag tacgatatcc     2940

caatggcgcg ccgagcttgg ctcgagcatg gtcatagctg tttcctgtgt gaaattgtta     3000

tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc     3060

ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg     3120

aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag gcggtttgcg     3180

tattgggcgc tgttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg     3240

gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa     3300

cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc     3360

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc     3420

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag     3480

ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct     3540

cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta     3600

ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc     3660

cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc     3720

agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt     3780

gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct     3840

gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc     3900

tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     3960

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     4020

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     4080

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttagaaaaa     4140

ctcatcgagc atcaaatgaa actgcaattt attcatatca ggattatcaa taccatattt     4200

ttgaaaaagc cgtttctgta atgaaggaga aaactcaccg aggcagttcc ataggatggc     4260

aagatcctgg tatcggtctg cgattccgac tcgtccaaca tcaatacaac ctattaattt     4320

cccctcgtca aaaataaggt tatcaagtga gaaatcacca tgagtgacga ctgaatccgg     4380

tgagaatggc aaaagtttat gcatttcttt ccagacttgt tcaacaggcc agccattacg     4440

ctcgtcatca aaatcactcg catcaaccaa accgttattc attcgtgatt gcgcctgagc     4500

gaaacgaaat acgcgatcgc tgttaaaagg acaattacaa acaggaatcg aatgcaaccg     4560

gcgcaggaac actgccagcg catcaacaat attttcacct gaatcaggat attcttctaa     4620

tacctggaat gctgttttcc cagggatcgc agtggtgagt aaccatgcat catcaggagt     4680

acggataaaa tgcttgatgg tcggaagagg cataaattcc gtcagccagt ttagtctgac     4740

catctcatct gtaacatcat tggcaacgct acctttgcca tgtttcagaa acaactctgg     4800

cgcatcgggc ttcccataca atcgatagat tgtcgcacct gattgcccga cattatcgcg     4860

agcccattta tacccatata aatcagcatc catgttggaa tttaatcgcg gcctagagca     4920

agacgtttcc cgttgaatat ggctcatact cttccttttt caatattatt gaagcattta     4980

tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat     5040

aggggttccg cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat     5100

catgacatta acctataaaa ataggcgtat cacgaggccc ttttgtctcg cgcgtttcgg     5160

tgatgacggt gaaaacctct gacacatgca gctcccggag actgtcacag cttgtctgta     5220

agcggatgcc gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg     5280

gggctggctt aactatgcgg catcagagca gattgtactg agagtgcacc atatgcggtg     5340

tgaaataccg cacagatgcg taaggagaaa ataccgcatc aggcgccatt cgccattcag     5400

gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac gccagctggc     5460

gaaaggggga tgtgctgcaa ggcgattaag ttgggtaacg ccagggtttt cccagtcacg     5520

acgttgtaaa acgacggcca gtgaattgac gcgttgcggc tgcatgaaat cctggccggt     5580

ttgtctgatg ccaagctggc ggcctggccg gccagcttgg ccgctgaaga aaccgagcgc     5640

cgccgtctaa aaaggtgatg tgtatttgag taaaacagct tgcgtcatgc ggtcgctgcg     5700

tatatgatgc gatgagtaaa taaacaaata cgcaagggga acgcatgaag gttatcgctg     5760

tacttaacca gaaaggcggg tcaggcaaga cgaccatcgc aacccatcta gcccgcgccc     5820

tgcaactcgc cggggccgat gttctgttag tcgattccga tccccagggc agtgcccgcg     5880

attgggcggc cgtgcgggaa gatcaaccgc taaccgttgt cggcatcgac cgcccgacga     5940

ttgaccgcga cgtgaaggcc atcggccggc gcgacttcgt agtgatcgac ggagcgcccc     6000

aggcggcgga cttggctgtg tccgcgatca aggcagccga cttcgtgctg attccggtgc     6060

agccaagccc ttacgacata tgggccaccg ccgacctggt ggagctggtt aagcagcgca     6120

ttgaggtcac ggatggaagg ctacaagcgg cctttgtcgt gtcgcgggcg atcaaaggca     6180

cgcgcatcgg cggtgaggtt gccgaggcgc tggccgggta cgagctgccc attcttgagt     6240

cccgtatcac gcagcgcgtg agctacccag gcactgccgc cgccggcaca accgttcttg     6300

aatcagaacc cgagggcgac gctgcccgcg aggtccaggc gctggccgct gaaattaaat     6360

caaaactcat ttgagttaat gaggtaaaga gaaaatgagc aaaagcacaa acacgctaag     6420

tgccggccgt ccgagcgcac gcagcagcaa ggctgcaacg ttggccagcc tggcagacac     6480

gccagccatg aagcgggtca actttcagtt gccggcggag gatcacacca agctgaagat     6540

gtacgcggta cgccaaggca agaccattac cgagctgcta tctgaataca tcgcgcagct     6600

accagagtaa atgagcaaat gaataaatga gtagatgaat tttagcggct aaaggaggcg     6660

gcatggaaaa tcaagaacaa ccaggcaccg acgccgtgga atgccccatg tgtggaggaa     6720

cgggcggttg gccaggcgta agcggctggg ttgtctgccg gccctgcaat ggcactggaa     6780

cccccaagcc cgaggaatcg gcgtgagcgg tcgcaaacca tccggcccgg tacaaatcgg     6840

cgcggcgctg ggtgatgacc tggtggagaa gttgaaggcc gcgcaggccg cccagcggca     6900

acgcatcgag gcagaagcac gccccggtga atcgtggcaa gcggccgctg atcgaatccg     6960

caaagaatcc cggcaaccgc cggcagccgg tgcgccgtcg attaggaagc cgcccaaggg     7020

cgacgagcaa ccagattttt tcgttccgat gctctatgac gtgggcaccc gcgatagtcg     7080

cagcatcatg gacgtggccg ttttccgtct gtcgaagcgt gaccgacgag ctggcgaggt     7140

gatccgctac gagcttccag acgggcacgt agaggtttcc gcagggccgg ccggcatggc     7200

cagtgtgtgg gattacgacc tggtactgat ggcggtttcc catctaaccg aatccatgaa     7260

ccgataccgg gaagggaagg gagacaagcc cggccgcgtg ttccgtccac acgttgcgga     7320

cgtactcaag ttctgccggc gagccgatgg cggaaagcag aaagacgacc tggtagaaac     7380

ctgcattcgg ttaaacacca cgcacgttgc catgcagcgt acgaagaagg ccaagaacgg     7440

ccgcctggtg acggtatccg agggtgaagc cttgattagc cgctacaaga tcgtaaagag     7500

cgaaaccggg cggccggagt acatcgagat cgagctagct gattggatgt accgcgagat     7560

cacagaaggc aagaacccgg acgtgctgac ggttcacccc gattactttt tgatcgatcc     7620

cggcatcggc cgttttctct accgcctggc acgccgcgcc gcaggcaagg cagaagccag     7680

atggttgttc aagacgatct acgaacgcag tggcagcgcc ggagagttca agaagttctg     7740

tttcaccgtg cgcaagctga tcgggtcaaa tgacctgccg gagtacgatt tgaaggagga     7800

ggcggggcag gctggcccga tcctagtcat gcgctaccgc aacctgatcg agggcgaagc     7860

atccgccggt tcctaatgta cggagcagat gctagggcaa attgccctag caggggaaaa     7920

aggtcgaaaa ggtctctttc ctgtggatag cacgtacatt gggaacccaa agccgtacat     7980

tgggaaccgg aacccgtaca ttgggaaccc aaagccgtac attgggaacc ggtcacacat     8040

gtaagtgact gatataaaag agaaaaaagg cgatttttcc gcctaaaact ctttaaaact     8100

tattaaaact cttaaaaccc gcctggcctg tgcatatgct agtcatgccc cgcgccca       8158


<210>  124
<211>  12647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE711 Full Plasmid Sequence

<400>  124
agcttactcg aggtcattca tatgcttgag aagagagtcg ggatagtcca aaataaaaca       60

aaggtaagat tacctggtca aaagtgaaaa catcagttaa aaggtggtat aaagtaaaat      120

atcggtaata aaaggtggcc caaagtgaaa tttactcttt tctactatta taaaaattga      180

ggatgttttt gtcggtactt tgatacgtca tttttgtatg aattggtttt taagtttatt      240

cgcttttgga aatgcatatc tgtatttgag tcgggtttta agttcgtttg cttttgtaaa      300

tacagaggga tttgtataag aaatatcttt agaaaaaccc atatgctaat ttgacataat      360

ttttgagaaa aatatatatt caggcgaatt ctcacaatga acaataataa gattaaaata      420

gctttccccc gttgcagcgc atgggtattt tttctagtaa aaataaaaga taaacttaga      480

ctcaaaacat ttacaaaaac aacccctaaa gttcctaaag cccaaagtgc tatccacgat      540

ccatagcaag cccagcccaa cccaacccaa cccaacccac cccagtccag ccaactggac      600

aatagtctcc acaccccccc actatcaccg tgagttgtcc gcacgcaccg cacgtctcgc      660

agccaaaaaa aaaaagaaag aaaaaaaaga aaaagaaaaa acagcaggtg ggtccgggtc      720

gtgggggccg gaaacgcgag gaggatcgcg agccagcgac gaggccggcc ctccctccgc      780

ttccaaagaa acgcccccca tcgccactat atacataccc ccccctctcc tcccatcccc      840

ccaaccctac caccaccacc accaccacct ccacctcctc ccccctcgct gccggacgac      900

gagctcctcc cccctccccc tccgccgccg ccgcgccggt aaccaccccg cccctctcct      960

ctttctttct ccgttttttt ttccgtctcg gtctcgatct ttggccttgg tagtttgggt     1020

gggcgagagg cggcttcgtg cgcgcccaga tcggtgcgcg ggaggggcgg gatctcgcgg     1080

ctggggctct cgccggcgtg gatccggccc ggatctcgcg gggaatgggg ctctcggatg     1140

tagatctgcg atccgccgtt gttgggggag atgatggggg gtttaaaatt tccgccgtgc     1200

taaacaagat caggaagagg ggaaaagggc actatggttt atatttttat atatttctgc     1260

tgcttcgtca ggcttagatg tgctagatct ttctttcttc tttttgtggg tagaatttga     1320

atccctcagc attgttcatc ggtagttttt cttttcatga tttgtgacaa atgcagcctc     1380

gtgcggagct tttttgtagg tagaagtgat caaccatggc gcaagttagc agaatctgca     1440

atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa cgcaaatctc     1500

ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt tcgtcgtcgt     1560

ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct cttaaggtca     1620

tgtcttctgt ttccacggcg tgcatgcttc acggtgcaag cagccggccc gcaaccgccc     1680

gcaaatcctc tggcctttcc ggaaccgtcc gcattcccgg cgacaagtcg atctcccacc     1740

ggtccttcat gttcggcggt ctcgcgagcg gtgaaacgcg catcaccggc cttctggaag     1800

gcgaggacgt catcaatacg ggcaaggcca tgcaggcgat gggcgcccgc atccgtaagg     1860

aaggcgacac ctggatcatc gatggcgtcg gcaatggcgg cctcctggcg cctgaggcgc     1920

cgctcgattt cggcaatgcc gccacgggct gccgcctgac gatgggcctc gtcggggtct     1980

acgatttcga cagcaccttc atcggcgacg cctcgctcac aaagcgcccg atgggccgcg     2040

tgttgaaccc gctgcgcgaa atgggcgtgc aggtgaaatc ggaagacggt gaccgtcttc     2100

ccgttacctt gcgcgggccg aagacgccga cgccgatcac ctaccgcgtg ccgatggcct     2160

ccgcacaggt gaagtccgcc gtgctgctcg ccggcctcaa cacgcccggc atcacgacgg     2220

tcatcgagcc gatcatgacg cgcgatcata cggaaaagat gctgcagggc tttggcgcca     2280

accttaccgt cgagacggat gcggacggcg tgcgcaccat ccgcctggaa ggccgcggca     2340

agctcaccgg ccaagtcatc gacgtgccgg gcgacccgtc ctcgacggcc ttcccgctgg     2400

ttgcggccct gcttgttccg ggctccgacg tcaccatcct caacgtgctg atgaacccca     2460

cccgcaccgg cctcatcctg acgctgcagg aaatgggcgc cgacatcgaa gtcatcaacc     2520

cgcgccttgc cggcggcgaa gacgtggcgg acctgcgcgt tcgctcctcc acgctgaagg     2580

gcgtcacggt gccggaagac cgcgcgcctt cgatgatcga cgaatatccg attctcgctg     2640

tcgccgccgc cttcgcggaa ggggcgaccg tgatgaacgg tctggaagaa ctccgcgtca     2700

aggaaagcga ccgcctctcg gccgtcgcca atggcctcaa gctcaatggc gtggattgcg     2760

atgagggcga gacgtcgctc gtcgtgcgtg gccgccctga cggcaagggg ctcggcaacg     2820

cctcgggcgc cgccgtcgcc acccatctcg atcaccgcat cgccatgagc ttcctcgtca     2880

tgggcctcgt gtcggaaaac cctgtcacgg tggacgatgc cacgatgatc gccacgagct     2940

tcccggagtt catggacctg atggccgggc tgggcgcgaa gatcgaactc tccgatacga     3000

aggctgcctg atgagctcga attcccgatc gttcaaacat ttggcaataa agtttcttaa     3060

gattgaatcc tgttgccggt cttgcgatga ttatcatata atttctgttg aattacgtta     3120

agcatgtaat aattaacatg taatgcatga cgttatttat gagatgggtt tttatgatta     3180

gagtcccgca attatacatt taatacgcga tagaaaacaa aatatagcgc gcaaactagg     3240

ataaattatc gcgcgcggtg tcatctatgt tactagatcg gggatggggg atccactagt     3300

gatatccgtc gactggtacc tacgcgtagc tagcccgtga agtttctcat ctaagccccc     3360

atttggacgt gaatgtagac acgtcgaaat aaagatttcc gaattagaat aatttgttta     3420

ttgctttcgc ctataaatac gacggatcgt aatttgtcgt tttatcaaaa tgtactttca     3480

ttttataata acgctgcgga catctacatt tttgaattga aaaaaaattg gtaattactc     3540

tttctttttc tccatattga ccatcatact cattgctgat ccatgtagat ttcccggaca     3600

tgaagccatt tacaattgaa tatatcctgc cgccgctgcc gctttgcacc cggtggagct     3660

tgcatgttgg tttctacgca gaactgagcc ggttaggcag ataatttcca ttgagaactg     3720

agccatgtgc accttccccc caacacggtg agcgacgggg caacggagtg atccacatgg     3780

gacttttcct agcttggctg ccatttttgg ggtgaggccg ttcgcggccg aggggcgcag     3840

cccctggggg gatgggaggc ccgcgttagc gggccgggag ggttcgagaa gggggggcac     3900

cccccttcgg cgtgcgcggt cacgcgcaca gggcgcagcc ctggttaaaa acaaggttta     3960

taaatattgg tttaaaagca ggttaaaaga caggttagcg gtggccgaaa aacgggcgga     4020

aacccttgca aatgctggat tttctgcctg tggacagccc ctcaaatgtc aataggtgcg     4080

cccctcatct gtcagcactc tgcccctcaa gtgtcaagga tcgcgcccct catctgtcag     4140

tagtcgcgcc cctcaagtgt caataccgca gggcacttat ccccaggctt gtccacatca     4200

tctgtgggaa actcgcgtaa aatcaggcgt tttcgccgat ttgcgaggct ggccagctcc     4260

acgtcgccgg ccgaaatcga gcctgcccct catctgtcaa cgccgcgccg ggtgagtcgg     4320

cccctcaagt gtcaacgtcc gcccctcatc tgtcagtgag ggccaagttt tccgcgaggt     4380

atccacaacg ccggcggccg gccgcggtgt ctcgcacacg gcttcgacgg cgtttctggc     4440

gcgtttgcag ggccatagac ggccgccagc ccagcggcga gggcaaccag cccggtgagc     4500

gtcggaaagg gtcgatcgac cgatgccctt gagagccttc aacccagtca gctccttccg     4560

gtgggcgcgg ggcatgacta tcgtcgccgc acttatgact gtcttcttta tcatgcaact     4620

cgtaggacag gtgccggcag cgctctgggt cattttcggc gaggaccgct ttcgctggag     4680

cgcgacgatg atcggcctgt cgcttgcggt attcggaatc ttgcacgccc tcgctcaagc     4740

cttcgtcact ggtcccgcca ccaaacgttt cggcgagaag caggccatta tcgccggcat     4800

ggcggccgac gcgctgggct acgtcttgct ggcgttcgcg acgcgaggct ggatggcctt     4860

ccccattatg attcttctcg cttccggcgg catcgggatg cccgcgttgc aggccatgct     4920

gtccaggcag gtagatgacg accatcaggg acagcttcaa ggatcgctcg cggctcttac     4980

cagcctaact tcgatcattg gaccgctgat cgtcacggcg atttatgccg cctcggcgag     5040

cacatggaac gggttggcat ggattgtagg cgccgcccta taccttgtct gcctccccgc     5100

gttgcgtcgc ggtgcatgga gccgggccac ctcgacctga atggaagccg gcggcacctc     5160

gctaacggat tcaccactcc aagaattgga gccaatcaat tcttgcggag aactgtgaat     5220

gcgcaaacca acccttggca gaacatatcc atcgcgtccg ccatctccag cagccgcacg     5280

cggcgcatct cgggcagcgt tgggtcctgg ccacgggtgc gcatgatcgt gctcctgtcg     5340

ttgaggaccc ggctaggctg gcggggttgc cttactggtt agcagaatga atcaccgata     5400

cgcgagcgaa cgtgaagcga ctgctgctgc aaaacgtctg cgacctgagc aacaacatga     5460

atggtcttcg gtttccgtgt ttcgtaaagt ctggaaacgc ggaagtcagc gccctgcacc     5520

attatgttcc ggatctgcat cgcaggatgc tgctggctac cctgtggaac acctacatct     5580

gtattaacga agcgctggca ttgaccctga gtgatttttc tctggtcccg ccgcatccat     5640

accgccagtt gtttaccctc acaacgttcc agtaaccggg catgttcatc atcagtaacc     5700

cgtatcgtga gcatcctctc tcgtttcatc ggtatcatta cccccatgaa cagaaatccc     5760

ccttacacgg aggcatcagt gaccaaacag gaaaaaaccg cccttaacat ggcccgcttt     5820

atcagaagcc agacattaac gcttctggag aaactcaacg agctggacgc ggatgaacag     5880

gcagacatct gtgaatcgct tcacgaccac gctgatgagc tttaccgcag ctgcctcgcg     5940

cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac ggtcacagct     6000

tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc     6060

gggtgtcggg gcgcagccat gacccagtca cgtagcgata gcggagtgta tactggctta     6120

actatgcggc atcagagcag attgtactga gagtgcacca tatgcggtgt gaaataccgc     6180

acagatgcgt aaggagaaaa taccgcatca ggcgctcttc cgcttcctcg ctcactgact     6240

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     6300

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     6360

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     6420

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     6480

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     6540

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     6600

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     6660

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     6720

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     6780

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga     6840

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     6900

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     6960

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     7020

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     7080

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     7140

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     7200

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     7260

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     7320

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     7380

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     7440

ttaatagttt gcgcaacgtt gttgccattg ctgcaggtcg ggagcacagg atgacgccta     7500

acaattcatt caagccgaca ccgcttcgcg gcgcggctta attcaggagt taaacatcat     7560

gagggaagcg gtgatcgccg aagtatcgac tcaactatca gaggtagttg gcgtcatcga     7620

gcgccatctc gaaccgacgt tgctggccgt acatttgtac ggctccgcag tggatggcgg     7680

cctgaagcca cacagtgata ttgatttgct ggttacggtg accgtaaggc ttgatgaaac     7740

aacgcggcga gctttgatca acgacctttt ggaaacttcg gcttcccctg gagagagcga     7800

gattctccgc gctgtagaag tcaccattgt tgtgcacgac gacatcattc cgtggcgtta     7860

tccagctaag cgcgaactgc aatttggaga atggcagcgc aatgacattc ttgcaggtat     7920

cttcgagcca gccacgatcg acattgatct ggctatcttg ctgacaaaag caagagaaca     7980

tagcgttgcc ttggtaggtc cagcggcgga ggaactcttt gatccggttc ctgaacagga     8040

tctatttgag gcgctaaatg aaaccttaac gctatggaac tcgccgcccg actgggctgg     8100

cgatgagcga aatgtagtgc ttacgttgtc ccgcatttgg tacagcgcag taaccggcaa     8160

aatcgcgccg aaggatgtcg ctgccgactg ggcaatggag cgcctgccgg cccagtatca     8220

gcccgtcata cttgaagcta ggcaggctta tcttggacaa gaagatcgct tggcctcgcg     8280

cgcagatcag ttggaagaat ttgttcacta cgtgaaaggc gagatcacca aggtagtcgg     8340

caaataatgt ctaacaattc gttcaagccg acgccgcttc gcggcgcggc ttaactcaag     8400

cgttagatgc tgcaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     8460

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     8520

gctccttcgg tcctccgatc gaggattttt cggcgctgcg ctacgtccgc gaccgcgttg     8580

agggatcaag ccacagcagc ccactcgacc ttctagccga cccagacgag ccaagggatc     8640

tttttggaat gctgctccgt cgtcaggctt tccgacgttt gggtggttga acagaagtca     8700

ttatcgcacg gaatgccaag cactcccgag gggaaccctg tggttggcat gcacatacaa     8760

atggacgaac ggataaacct tttcacgccc ttttaaatat ccgattattc taataaacgc     8820

tcttttctct taggtttacc cgccaatata tcctgtcaaa cactgatagt ttaaactgaa     8880

ggcgggaaac gacaatctgg cgcgcctagc taactagcta gccacgtgac tcgcagaacg     8940

ttgtgtggcg agacggaaag aaagtcacgc ctccaaagag tgcagcatct cttctggctc     9000

tcacggtcct ctgtggatcc atcgatatcg aattcctgca ggctcgaggt cattcatatg     9060

cttgagaaga gagtcgggat agtccaaaat aaaacaaagg taagattacc tggtcaaaag     9120

tgaaaacatc agttaaaagg tggtataaag taaaatatcg gtaataaaag gtggcccaaa     9180

gtgaaattta ctcttttcta ctattataaa aattgaggat gtttttgtcg gtactttgat     9240

acgtcatttt tgtatgaatt ggtttttaag tttattcgct tttggaaatg catatctgta     9300

tttgagtcgg gttttaagtt cgtttgcttt tgtaaataca gagggatttg tataagaaat     9360

atctttagaa aaacccatat gctaatttga cataattttt gagaaaaata tatattcagg     9420

cgaattctca caatgaacaa taataagatt aaaatagctt tcccccgttg cagcgcatgg     9480

gtattttttc tagtaaaaat aaaagataaa cttagactca aaacatttac aaaaacaacc     9540

cctaaagttc ctaaagccca aagtgctatc cacgatccat agcaagccca gcccaaccca     9600

acccaaccca acccacccca gtccagccaa ctggacaata gtctccacac ccccccacta     9660

tcaccgtgag ttgtccgcac gcaccgcacg tctcgcagcc aaaaaaaaaa agaaagaaaa     9720

aaaagaaaaa gaaaaaacag caggtgggtc cgggtcgtgg gggccggaaa cgcgaggagg     9780

atcgcgagcc agcgacgagg agcttaggcc tcatcgttga agatgcctct gccgacagtg     9840

gtcccaaaga tggaccccca cccacgagga gcatcgtgga aaaagaagac gttccaacca     9900

cgtcttcaaa gcaagtggat tgatgtgata tctccactga cgtaagggat gacgcacaat     9960

cccactatcc ttcgaggcct catcgttgaa gatgcctctg ccgacagtgg tcccaaagat    10020

ggacccccac ccacgaggag catcgtggaa aaagaagacg ttccaaccac gtcttcaaag    10080

caagtggatt gatgtgatat ctccactgac gtaagggatg acgcacaatc ccactatcct    10140

tcgaagctcc ctccctccgc ttccaaagaa acgcccccca tcgccactat atacataccc    10200

ccccctctcc tcccatcccc ccaacccttc tagaaccatc ttccacacac tcaagccaca    10260

ctattggaga acacacaggg acaacacacc ataagatcca agggaggcct ccgccgccgc    10320

cggtaaccac cccgcccctc tcctctttct ttctccgttt ttttttccgt ctcggtctcg    10380

atctttggcc ttggtagttt gggtgggcga gaggcggctt cgtgcgcgcc cagatcggtg    10440

cgcgggaggg gcgggatctc gcggctgggg ctctcgccgg cgtggatccg gcccggatct    10500

cgcggggaat ggggctctcg gatgtagatc tgcgatccgc cgttgttggg ggagatgatg    10560

gggggtttaa aatttccgcc gtgctaaaca agatcaggaa gaggggaaaa gggcactatg    10620

gtttatattt ttatatattt ctgctgcttc gtcaggctta gatgtgctag atctttcttt    10680

cttctttttg tgggtagaat ttgaatccct cagcattgtt catcggtagt ttttcttttc    10740

atgatttgtg acaaatgcag cctcgtgcgg agcttttttg taggtagaag gcggccgcat    10800

ggcccagtct aagcacgggt tgacgaagga gatgactatg aagtatcgca tggaaggctg    10860

cgttgacggc cacaaattcg tcattaccgg cgagggcatc ggctacccct ttaaggtaag    10920

tttctgcttc tacctttgat atatatataa taattatcat taattagtag taatataata    10980

tttcaaatat ttttttcaaa ataaaagaat gtagtatata gcaattgctt ttctgtagtt    11040

tataagtgtg tatattttaa tttataactt ttctaatata tgaccaaaat ttgttgatgt    11100

gcagggcaag caagcgataa acctgtgcgt ggtggagggt ggccctctgc ccttcgccga    11160

ggatatactc tcagccgcct tcatgtacgg gaatcgggtg ttcacggagt acccgcaaga    11220

catcgtggac tacttcaaga actcctgccc cgccggatac acatgggacc gttccttcct    11280

cttcgaggac ggagccgttt gcatctgcaa cgcggacatc accgtgtccg tcgaggagaa    11340

ctgcatgtac cacgagtcaa agttctatgg agtgaacttc ccggccgatg gtcccgtgat    11400

gaagaaaatg acggacaact gggagccgtc gtgcgagaaa atcattcccg tcccaaaaca    11460

gggaatcctc aagggcgacg tgtcgatgta cctacttctc aaggacggtg gacggctacg    11520

gtgccagttc gacactgttt acaaggcgaa gtcggtgccg aggaagatgc cggactggca    11580

ctttatccag cacaagctga caagggagga cagaagcgac gctaagaacc agaaatggca    11640

cctcaccgag cacgccatcg ccagtggctc tgcgctgccc gggtgaccct gcaatgtgac    11700

cctagacttg tccatcttct ggattggcca acttaattaa tgtatgaaat aaaaggatgc    11760

acacatagtg acatgctaat cactataatg tgggcatcaa agttgtgtgt tatgtgtaat    11820

tactaattat ctgaataaga gaaagagatc atccatattt cttatcctaa atgaatgtca    11880

cgtgtcttta taattctttg atgaaccaga tgcattttat taaccaattc catatacata    11940

taaatattaa tcatatataa ttaatatcaa ttgggttagc aaaacaaatc tagtctaggt    12000

gtgttttgct aattattggg ggatagtgca aaaagaaatc tacgttctca ataattcaga    12060

tagaaaactt aataaagtga gataatttac atagattgct tttatccttt gatatatgtg    12120

aaaccatgca tgatataagg aaaatagata gagaaataat tttttacatc gttgaatatg    12180

taaacaattt aattcaagaa gctaggaata taaatattga ggagtttatg attattatta    12240

ttattttgat gttcaatgaa gtttttttta atttcatatg aagtatacaa aaattcttca    12300

tagatttttg tttctatgcc gtagttatct ttaatatatt tgtggttgaa gaaatttatt    12360

gctagaaacg aatggattgt caattttttt ttaaagcaaa tatatatgaa attatactgt    12420

atattatttt agtcatgatt aaaatgtggc cttaattgaa tcatctttct cattcatttt    12480

ttcaaaagca tatcaggatg attgatattt atctatttta aaaattaatt taagggttca    12540

aattaaattt aacttaaaag tgtcctaacc gtagttaaag gtttacttta aaaaaatact    12600

atgaaaaatc taatcttcta tgaatcgagg gcccttagct agttaga                  12647


<210>  125
<211>  10918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3111 Full Plasmid Sequence

<400>  125
gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt       60

gcctaatgag tgagctaact tacattaatt gcgttgcgcc ccgggatgag attatcaaaa      120

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata      180

tatgtgtaac attggtctag tgattggatc cttgacagct agctcagtcc taggtactgt      240

gctagcgcta gcaaagagga gaaaggtacc atgcccgatc gagctcaagt tatcattcgc      300

attgtgccgg gaggtggcac caagaccctt caacaaatta tcaatcagtt ggagtatcta      360

tcccggaagg gcaggctgga gctgcagcgt tcagcccgac atctcgatat tcccctgcca      420

ccggatcaaa tccacgaact tgcccgaagc tgggttcaag agactggaac ttatgacgaa      480

agtcagccag acgaggaaag gcaacaggag ttgaccaccc atattattgt aagcttcccc      540

gccggtacaa gccaggtagc ggcttatgcg gcgagccggg agtgggcagc cgagatgttt      600

gggtcaggcg cagggggggg ccgatacaac tatcttacgg ccttccacat cgatcgcgac      660

cacccacatc tgcatgtcgt cgtcaatcgg cgcgaacttt taggacacgg ctggctgaag      720

atatctcggc gccatcccca actgaattac gacgccctgc gcataaagat ggccgagatt      780

tcacttcgtc atggcattgc cctcgatgcg agccgacgag cagaacgtgg catcaccgag      840

cggccgatca cttatgccca atatcggcgc cttgagcggg agcaggctcg ccaaatccgt      900

ttcgaagacg cggatttgga acagtcgtcg ccgcaaggag atcatccaga attcagccaa      960

cctttcgata catccccatt tgaagcatcc gcgggcggac cggaggacat gcctcggccc     1020

aacaatcggc agaatgagtc gcaagttcat ctccaggagc cagctggtgt cagcaacgaa     1080

gccggtgtcc ttgtgcgggt tgcattggaa acggagcgcc ttgctcaacc attcgtttcc     1140

gaaaccattc tcgcggacga catagggagc ggctcttcgc gtgttgccga gggccgtgtg     1200

gagagcgcaa accgcactcc cgatattcct cgcgcagcaa ctgaagctgc cacgcacacg     1260

acacacgacc ggcagcggcg tgcaaagcgt cctcatgatg acgacggagg gccgagtgga     1320

gcaaaacgtg tgacattgga aggcatcgcg gttgggcccc aggcgaacgc cggcgaacag     1380

gatggcagta gtggcccctt agtacggcaa gctggaacgt cacggccatc tccaccgacg     1440

gccacgacgc gggccagcac cgcaaccgat tcattgtctg ctacagccca cctccagcaa     1500

cggagaggtg tcctttcaaa gcgtccgcgt gaagatgatg atggagaacc gagtgaacgc     1560

aaacgcgaga gagatgagcg cagcaaggac gggcgtgggg gaaataggag aagcggtggc     1620

tcctcgggtg gcagcatgag cggctccaag aagcgccgca tcaagcaaga ttcaaagctg     1680

gagaagttca ccaactgcta ctcgctgagc aagacgctgc ggttcaaggc catccccgtg     1740

ggcaagaccc aggagaacat cgacaacaag cgcctcctgg tcgaggacga gaagcgcgcc     1800

gaggactaca agggcgtcaa gaagctcctg gaccggtatt acctcagctt catcaacgac     1860

gtgctgcact cgatcaagct caagaacctg aacaactaca tcagcctgtt ccgcaagaaa     1920

acgcgcaccg agaaggagaa caaagagctg gagaacctgg agatcaacct gcggaaggag     1980

attgcgaaag ctttcaaggg caacgagggc tacaagtcgc tcttcaagaa agacataatc     2040

gagaccatcc tgccggagtt cctggacgac aaggacgaga tcgcgctcgt caactcgttc     2100

aacgggttca ctacggcctt cacgggtttc ttcgataacc gggagaatat gtttagcgag     2160

gaggccaagt ccacctccat tgcgttccgc tgcatcaacg agaacctgac ccgctacatc     2220

agcaacatgg acatcttcga gaaggtggac gccatcttcg acaagcacga ggtccaggag     2280

atcaaggaga agattctgaa ctcggactac gacgtggaag acttcttcga gggcgagttt     2340

ttcaacttcg tcctgaccca ggaggggatc gacgtttata acgccatcat cggcgggttc     2400

gtcacggagt cgggcgaaaa gatcaagggc ctgaacgagt atattaacct gtacaaccag     2460

aagacaaagc agaagctgcc gaagttcaag ccgctgtaca agcaagtcct gtccgaccgc     2520

gagtcgctgt cgttctacgg cgaaggctac acctcggacg aggaggtgct ggaggtgttc     2580

cgcaacaccc tgaacaagaa tagcgaaatt tttagctcca ttaagaagct cgagaagctg     2640

ttcaagaact tcgacgagta cagcagcgcc gggatcttcg tcaagaacgg ccccgcgatc     2700

agcaccatct cgaaggacat cttcggcgag tggaacgtca tccgggacaa gtggaacgcc     2760

gagtacgacg acattcacct taaaaagaag gctgttgtga cggagaagta cgaggacgac     2820

cggcgcaagt cgttcaaaaa gatcggctcc ttctccctgg agcagctcca ggagtacgcc     2880

gacgccgacc tctcggtcgt cgagaagctc aaggagatca tcattcagaa ggtggacgaa     2940

atttacaaag tgtacggctc cagcgagaag ctgttcgacg ccgacttcgt gctggaaaag     3000

tcgctcaaga aaaacgacgc cgtggtggcc atcatgaagg acttgctgga cagcgtgaag     3060

tcgttcgaga actacattaa ggcgttcttt ggcgagggca aggagaccaa ccgcgacgag     3120

tcgttctacg gcgacttcgt gctcgcgtac gacatcctgc tcaaggtgga tcacatctac     3180

gacgcgatcc gcaactacgt cacgcagaag ccgtactcga aggacaagtt caagctgtac     3240

ttccagaacc cgcagttcat gggcgggtgg gacaaggaca aggaaacgga ctaccgcgcg     3300

accatcctgc ggtacggcag caagtattat ctggcgatca tggacaaaaa atatgccaag     3360

tgcctccaga aaatcgacaa ggacgacgtg aacggcaact acgagaagat taattacaag     3420

ctgctccccg gccccaacaa gatgctcccg aaggtgttct ttagcaagaa gtggatggcc     3480

tactacaacc cgagcgagga catccagaag atctataaga atggcacctt caagaaggga     3540

gacatgttta acctcaacga ctgccacaag ctgattgact tcttcaagga ctcgatctcg     3600

cgctacccga agtggtcgaa cgcctacgac ttcaacttca gcgaaacgga gaaatacaaa     3660

gacatcgcgg gcttctaccg cgaggtcgag gagcaaggct acaaggtcag cttcgagtcc     3720

gccagcaaga aggaggtgga caagctggtg gaggagggca agctctacat gtttcagatc     3780

tacaacaagg attttagcga caagtcgcac ggcacgccga acctgcacac gatgtacttc     3840

aagctgctgt tcgacgagaa caaccacggc cagatccggc tgtcgggcgg tgcggagctg     3900

ttcatgcgcc gggcgtcgct caagaaggaa gagctggtcg tccacccggc caacagcccc     3960

atcgccaaca agaaccccga caaccccaag aaaacgacga cactcagcta tgatgtctat     4020

aaagacaagc gcttctcgga ggaccagtac gagctgcaca tccccatcgc catcaacaag     4080

tgccccaaga acatcttcaa gatcaacacg gaggtccgcg tgctcctcaa gcacgacgac     4140

aacccgtacg tcatcggcat cgaccggggc gagcgcaacc tgctgtacat cgtcgtcgtc     4200

gatggcaagg gcaacatcgt ggagcagtat tccctgaacg agatcatcaa caacttcaac     4260

ggcatccgca tcaagaccga ctaccactcc ctcctcgaca agaaggagaa agagcgcttc     4320

gaggcccgcc agaactggac ctccatcgag aacatcaagg agcttaaggc gggctacatc     4380

tcccaagtcg tccacaagat ctgcgagctg gtcgagaagt acgacgcggt gatcgccctg     4440

gaagacctga actccggctt caagaactcc cgcgtaaagg tggagaagca agtgtaccag     4500

aagttcgaga agatgctgat cgacaagctg aactacatgg tggacaagaa atcgaacccg     4560

tgcgcgaccg gcggcgcgct caagggctac cagatcacga acaagttcga gtcgttcaag     4620

tccatgagca cgcagaacgg ctttatcttc tacatcccgg cctggctgac gtcgaagatc     4680

gacccctcga ccggcttcgt gaacctgctc aagaccaagt atactagcat tgccgactcc     4740

aagaaattca tctcgtcctt cgaccgcatc atgtacgtcc cggaggagga cctttttgag     4800

ttcgccctcg actacaagaa cttcagccgc accgacgccg actacatcaa gaagtggaag     4860

ctgtactcgt acgggaaccg catccgtatt tttcgcaacc cgaagaaaaa taatgtcttc     4920

gactgggagg aggtgtgcct gaccagcgcc tacaaggagc tgttcaacaa gtacggcatc     4980

aactaccaac agggcgacat ccgggccctt ctctgcgagc agagcgacaa ggcgttctac     5040

tcgtcgttca tggccctgat gagcctgatg ctccagatga ggaacagcat caccggccgc     5100

accgacgtgg acttcctcat cagccccgtc aagaactcgg acggcatatt ttatgactcg     5160

cggaactacg aggcccagga gaacgccatc ctgcccaaga acgccgacgc caacggcgcg     5220

tacaacatcg cccgcaaggt gctctgggcc atcggccagt tcaagaaggc ggaagacgag     5280

aagctggaca aggtgaagat cgccatctcc aacaaggagt ggctggagta cgcgcagacg     5340

tccgtcaagc acggctccaa gaaacggcgg atcaaacaag attccggtgg cagttccggt     5400

ggcagcagtg cgtcgttagc aagaggcggt ccaaatgcag tgggactcct aacgacgaac     5460

gaaagctttg agaaaaatat caatgaggtc tacaaccgta cgcgagccga gctagacgct     5520

tcttcacgtg acagaagtcg ctctggacta tcgcgataat ctagaccagg catcaaataa     5580

aacgaaaggc tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg     5640

ctctctacta gagtcacact ggctcacctt cgggtgggcc tttctgcgtt tatagtacga     5700

tatcccaatg gcgcgccgag cttggctcga gcatggtcat agctgtttcc tgtgtgaaat     5760

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg     5820

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag     5880

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     5940

ttgcgtattg ggcgctgttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg     6000

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg     6060

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     6120

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     6180

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     6240

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     6300

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg     6360

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     6420

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     6480

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     6540

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct     6600

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     6660

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     6720

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     6780

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     6840

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttag     6900

aaaaactcat cgagcatcaa atgaaactgc aatttattca tatcaggatt atcaatacca     6960

tatttttgaa aaagccgttt ctgtaatgaa ggagaaaact caccgaggca gttccatagg     7020

atggcaagat cctggtatcg gtctgcgatt ccgactcgtc caacatcaat acaacctatt     7080

aatttcccct cgtcaaaaat aaggttatca agtgagaaat caccatgagt gacgactgaa     7140

tccggtgaga atggcaaaag tttatgcatt tctttccaga cttgttcaac aggccagcca     7200

ttacgctcgt catcaaaatc actcgcatca accaaaccgt tattcattcg tgattgcgcc     7260

tgagcgaaac gaaatacgcg atcgctgtta aaaggacaat tacaaacagg aatcgaatgc     7320

aaccggcgca ggaacactgc cagcgcatca acaatatttt cacctgaatc aggatattct     7380

tctaatacct ggaatgctgt tttcccaggg atcgcagtgg tgagtaacca tgcatcatca     7440

ggagtacgga taaaatgctt gatggtcgga agaggcataa attccgtcag ccagtttagt     7500

ctgaccatct catctgtaac atcattggca acgctacctt tgccatgttt cagaaacaac     7560

tctggcgcat cgggcttccc atacaatcga tagattgtcg cacctgattg cccgacatta     7620

tcgcgagccc atttataccc atataaatca gcatccatgt tggaatttaa tcgcggccta     7680

gagcaagacg tttcccgttg aatatggctc atactcttcc tttttcaata ttattgaagc     7740

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     7800

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt     7860

attatcatga cattaaccta taaaaatagg cgtatcacga ggcccttttg tctcgcgcgt     7920

ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagactgt cacagcttgt     7980

ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg     8040

tgtcggggct ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatatg     8100

cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ccattcgcca     8160

ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag     8220

ctggcgaaag ggggatgtgc tgcaaggcga ttaagttggg taacgccagg gttttcccag     8280

tcacgacgtt gtaaaacgac ggccagtgaa ttgacgcgtt gcggctgcat gaaatcctgg     8340

ccggtttgtc tgatgccaag ctggcggcct ggccggccag cttggccgct gaagaaaccg     8400

agcgccgccg tctaaaaagg tgatgtgtat ttgagtaaaa cagcttgcgt catgcggtcg     8460

ctgcgtatat gatgcgatga gtaaataaac aaatacgcaa ggggaacgca tgaaggttat     8520

cgctgtactt aaccagaaag gcgggtcagg caagacgacc atcgcaaccc atctagcccg     8580

cgccctgcaa ctcgccgggg ccgatgttct gttagtcgat tccgatcccc agggcagtgc     8640

ccgcgattgg gcggccgtgc gggaagatca accgctaacc gttgtcggca tcgaccgccc     8700

gacgattgac cgcgacgtga aggccatcgg ccggcgcgac ttcgtagtga tcgacggagc     8760

gccccaggcg gcggacttgg ctgtgtccgc gatcaaggca gccgacttcg tgctgattcc     8820

ggtgcagcca agcccttacg acatatgggc caccgccgac ctggtggagc tggttaagca     8880

gcgcattgag gtcacggatg gaaggctaca agcggccttt gtcgtgtcgc gggcgatcaa     8940

aggcacgcgc atcggcggtg aggttgccga ggcgctggcc gggtacgagc tgcccattct     9000

tgagtcccgt atcacgcagc gcgtgagcta cccaggcact gccgccgccg gcacaaccgt     9060

tcttgaatca gaacccgagg gcgacgctgc ccgcgaggtc caggcgctgg ccgctgaaat     9120

taaatcaaaa ctcatttgag ttaatgaggt aaagagaaaa tgagcaaaag cacaaacacg     9180

ctaagtgccg gccgtccgag cgcacgcagc agcaaggctg caacgttggc cagcctggca     9240

gacacgccag ccatgaagcg ggtcaacttt cagttgccgg cggaggatca caccaagctg     9300

aagatgtacg cggtacgcca aggcaagacc attaccgagc tgctatctga atacatcgcg     9360

cagctaccag agtaaatgag caaatgaata aatgagtaga tgaattttag cggctaaagg     9420

aggcggcatg gaaaatcaag aacaaccagg caccgacgcc gtggaatgcc ccatgtgtgg     9480

aggaacgggc ggttggccag gcgtaagcgg ctgggttgtc tgccggccct gcaatggcac     9540

tggaaccccc aagcccgagg aatcggcgtg agcggtcgca aaccatccgg cccggtacaa     9600

atcggcgcgg cgctgggtga tgacctggtg gagaagttga aggccgcgca ggccgcccag     9660

cggcaacgca tcgaggcaga agcacgcccc ggtgaatcgt ggcaagcggc cgctgatcga     9720

atccgcaaag aatcccggca accgccggca gccggtgcgc cgtcgattag gaagccgccc     9780

aagggcgacg agcaaccaga ttttttcgtt ccgatgctct atgacgtggg cacccgcgat     9840

agtcgcagca tcatggacgt ggccgttttc cgtctgtcga agcgtgaccg acgagctggc     9900

gaggtgatcc gctacgagct tccagacggg cacgtagagg tttccgcagg gccggccggc     9960

atggccagtg tgtgggatta cgacctggta ctgatggcgg tttcccatct aaccgaatcc    10020

atgaaccgat accgggaagg gaagggagac aagcccggcc gcgtgttccg tccacacgtt    10080

gcggacgtac tcaagttctg ccggcgagcc gatggcggaa agcagaaaga cgacctggta    10140

gaaacctgca ttcggttaaa caccacgcac gttgccatgc agcgtacgaa gaaggccaag    10200

aacggccgcc tggtgacggt atccgagggt gaagccttga ttagccgcta caagatcgta    10260

aagagcgaaa ccgggcggcc ggagtacatc gagatcgagc tagctgattg gatgtaccgc    10320

gagatcacag aaggcaagaa cccggacgtg ctgacggttc accccgatta ctttttgatc    10380

gatcccggca tcggccgttt tctctaccgc ctggcacgcc gcgccgcagg caaggcagaa    10440

gccagatggt tgttcaagac gatctacgaa cgcagtggca gcgccggaga gttcaagaag    10500

ttctgtttca ccgtgcgcaa gctgatcggg tcaaatgacc tgccggagta cgatttgaag    10560

gaggaggcgg ggcaggctgg cccgatccta gtcatgcgct accgcaacct gatcgagggc    10620

gaagcatccg ccggttccta atgtacggag cagatgctag ggcaaattgc cctagcaggg    10680

gaaaaaggtc gaaaaggtct ctttcctgtg gatagcacgt acattgggaa cccaaagccg    10740

tacattggga accggaaccc gtacattggg aacccaaagc cgtacattgg gaaccggtca    10800

cacatgtaag tgactgatat aaaagagaaa aaaggcgatt tttccgccta aaactcttta    10860

aaacttatta aaactcttaa aacccgcctg gcctgtgcat atgctagtca tgccccgc      10918


<210>  126
<211>  10774
<212>  DNA
<213>  pWISE3118 Full Plasmid Sequence

<400>  126
cggaaggagc tgactgggtt gaaggctctc aagggcatcg gtcgagatcc cggtgcctaa       60

tgagtgagct aacttacatt aattgcgttg cgccccggga tgagattatc aaaaaggatc      120

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgtg      180

taacattggt ctagtgattg gatccttgac agctagctca gtcctaggta ctgtgctagc      240

gctagcaaag aggagaaagg taccatgccc gatcgagctc aagttatcat tcgcattgtg      300

ccgggaggtg gcaccaagac ccttcaacaa attatcaatc agttggagta tctatcccgg      360

aagggcaggc tggagctgca gcgttcagcc cgacatctcg atattcccct gccaccggat      420

caaatccacg aacttgcccg aagctgggtt caagagactg gaacttatga cgaaagtcag      480

ccagacgagg aaaggcaaca ggagttgacc acccatatta ttgtaagctt ccccgccggt      540

acaagccagg tagcggctta tgcggcgagc cgggagtggg cagccgagat gtttgggtca      600

ggcgcagggg ggggccgata caactatctt acggccttcc acatcgatcg cgaccaccca      660

catctgcatg tcgtcgtcaa tcggcgcgaa cttttaggac acggctggct gaagatatct      720

cggcgccatc cccaactgaa ttacgacgcc ctgcgcataa agatggccga gatttcactt      780

cgtcatggca ttgccctcga tgcgagccga cgagcagaac gtggcatcac cgagcggccg      840

atcacttatg cccaatatcg gcgccttgag cgggagcagg ctcgccaaat ccgtttcgaa      900

gacgcggatt tggaacagtc gtcgccgcaa ggagatcatc cagaattcag ccaacctttc      960

gatacatccc catttgaagc atccgcgggc ggaccggagg acatgcctcg gcccaacaat     1020

cggcagaatg agtcgcaagt tcatctccag gagccagctg gtgtcagcaa cgaagccggt     1080

gtccttgtgc gggttgcatt ggaaacggag cgccttgctc aaccattcgt ttccgaaacc     1140

attctcgcgg acgacatagg gagcggctct tcgcgtgttg ccgagggccg tgtggagagc     1200

gcaaaccgca ctcccgatat tcctcgcgca gcaactgaag ctgccacgca cacgacacac     1260

gaccggcagc ggcgtgcaaa gcgtcctcat gatgacgacg gagggccgag tggagcaaaa     1320

cgtgtgacat tggaaggcat cgcggttggg ccccaggcga acgccggcga acaggatggc     1380

agtagtgggg gctcctcggg tggcagcatg agcggctcca agaagcgccg catcaagcaa     1440

gattcaaagc tggagaagtt caccaactgc tactcgctga gcaagacgct gcggttcaag     1500

gccatccccg tgggcaagac ccaggagaac atcgacaaca agcgcctcct ggtcgaggac     1560

gagaagcgcg ccgaggacta caagggcgtc aagaagctcc tggaccggta ttacctcagc     1620

ttcatcaacg acgtgctgca ctcgatcaag ctcaagaacc tgaacaacta catcagcctg     1680

ttccgcaaga aaacgcgcac cgagaaggag aacaaagagc tggagaacct ggagatcaac     1740

ctgcggaagg agattgcgaa agctttcaag ggcaacgagg gctacaagtc gctcttcaag     1800

aaagacataa tcgagaccat cctgccggag ttcctggacg acaaggacga gatcgcgctc     1860

gtcaactcgt tcaacgggtt cactacggcc ttcacgggtt tcttcgataa ccgggagaat     1920

atgtttagcg aggaggccaa gtccacctcc attgcgttcc gctgcatcaa cgagaacctg     1980

acccgctaca tcagcaacat ggacatcttc gagaaggtgg acgccatctt cgacaagcac     2040

gaggtccagg agatcaagga gaagattctg aactcggact acgacgtgga agacttcttc     2100

gagggcgagt ttttcaactt cgtcctgacc caggagggga tcgacgttta taacgccatc     2160

atcggcgggt tcgtcacgga gtcgggcgaa aagatcaagg gcctgaacga gtatattaac     2220

ctgtacaacc agaagacaaa gcagaagctg ccgaagttca agccgctgta caagcaagtc     2280

ctgtccgacc gcgagtcgct gtcgttctac ggcgaaggct acacctcgga cgaggaggtg     2340

ctggaggtgt tccgcaacac cctgaacaag aatagcgaaa tttttagctc cattaagaag     2400

ctcgagaagc tgttcaagaa cttcgacgag tacagcagcg ccgggatctt cgtcaagaac     2460

ggccccgcga tcagcaccat ctcgaaggac atcttcggcg agtggaacgt catccgggac     2520

aagtggaacg ccgagtacga cgacattcac cttaaaaaga aggctgttgt gacggagaag     2580

tacgaggacg accggcgcaa gtcgttcaaa aagatcggct ccttctccct ggagcagctc     2640

caggagtacg ccgacgccga cctctcggtc gtcgagaagc tcaaggagat catcattcag     2700

aaggtggacg aaatttacaa agtgtacggc tccagcgaga agctgttcga cgccgacttc     2760

gtgctggaaa agtcgctcaa gaaaaacgac gccgtggtgg ccatcatgaa ggacttgctg     2820

gacagcgtga agtcgttcga gaactacatt aaggcgttct ttggcgaggg caaggagacc     2880

aaccgcgacg agtcgttcta cggcgacttc gtgctcgcgt acgacatcct gctcaaggtg     2940

gatcacatct acgacgcgat ccgcaactac gtcacgcaga agccgtactc gaaggacaag     3000

ttcaagctgt acttccagaa cccgcagttc atgggcgggt gggacaagga caaggaaacg     3060

gactaccgcg cgaccatcct gcggtacggc agcaagtatt atctggcgat catggacaaa     3120

aaatatgcca agtgcctcca gaaaatcgac aaggacgacg tgaacggcaa ctacgagaag     3180

attaattaca agctgctccc cggccccaac aagatgctcc cgaaggtgtt ctttagcaag     3240

aagtggatgg cctactacaa cccgagcgag gacatccaga agatctataa gaatggcacc     3300

ttcaagaagg gagacatgtt taacctcaac gactgccaca agctgattga cttcttcaag     3360

gactcgatct cgcgctaccc gaagtggtcg aacgcctacg acttcaactt cagcgaaacg     3420

gagaaataca aagacatcgc gggcttctac cgcgaggtcg aggagcaagg ctacaaggtc     3480

agcttcgagt ccgccagcaa gaaggaggtg gacaagctgg tggaggaggg caagctctac     3540

atgtttcaga tctacaacaa ggattttagc gacaagtcgc acggcacgcc gaacctgcac     3600

acgatgtact tcaagctgct gttcgacgag aacaaccacg gccagatccg gctgtcgggc     3660

ggtgcggagc tgttcatgcg ccgggcgtcg ctcaagaagg aagagctggt cgtccacccg     3720

gccaacagcc ccatcgccaa caagaacccc gacaacccca agaaaacgac gacactcagc     3780

tatgatgtct ataaagacaa gcgcttctcg gaggaccagt acgagctgca catccccatc     3840

gccatcaaca agtgccccaa gaacatcttc aagatcaaca cggaggtccg cgtgctcctc     3900

aagcacgacg acaacccgta cgtcatcggc atcgaccggg gcgagcgcaa cctgctgtac     3960

atcgtcgtcg tcgatggcaa gggcaacatc gtggagcagt attccctgaa cgagatcatc     4020

aacaacttca acggcatccg catcaagacc gactaccact ccctcctcga caagaaggag     4080

aaagagcgct tcgaggcccg ccagaactgg acctccatcg agaacatcaa ggagcttaag     4140

gcgggctaca tctcccaagt cgtccacaag atctgcgagc tggtcgagaa gtacgacgcg     4200

gtgatcgccc tggaagacct gaactccggc ttcaagaact cccgcgtaaa ggtggagaag     4260

caagtgtacc agaagttcga gaagatgctg atcgacaagc tgaactacat ggtggacaag     4320

aaatcgaacc cgtgcgcgac cggcggcgcg ctcaagggct accagatcac gaacaagttc     4380

gagtcgttca agtccatgag cacgcagaac ggctttatct tctacatccc ggcctggctg     4440

acgtcgaaga tcgacccctc gaccggcttc gtgaacctgc tcaagaccaa gtatactagc     4500

attgccgact ccaagaaatt catctcgtcc ttcgaccgca tcatgtacgt cccggaggag     4560

gacctttttg agttcgccct cgactacaag aacttcagcc gcaccgacgc cgactacatc     4620

aagaagtgga agctgtactc gtacgggaac cgcatccgta tttttcgcaa cccgaagaaa     4680

aataatgtct tcgactggga ggaggtgtgc ctgaccagcg cctacaagga gctgttcaac     4740

aagtacggca tcaactacca acagggcgac atccgggccc ttctctgcga gcagagcgac     4800

aaggcgttct actcgtcgtt catggccctg atgagcctga tgctccagat gaggaacagc     4860

atcaccggcc gcaccgacgt ggacttcctc atcagccccg tcaagaactc ggacggcata     4920

ttttatgact cgcggaacta cgaggcccag gagaacgcca tcctgcccaa gaacgccgac     4980

gccaacggcg cgtacaacat cgcccgcaag gtgctctggg ccatcggcca gttcaagaag     5040

gcggaagacg agaagctgga caaggtgaag atcgccatct ccaacaagga gtggctggag     5100

tacgcgcaga cgtccgtcaa gcacggctcc aagaaacggc ggatcaaaca agattccggt     5160

agtggggggt cctctggtgg aagtagtggc cccttagtac ggcaagctgg aacgtcacgg     5220

ccatctccac cgacggccac gacgcgggcc agcaccgcaa ccgattcatt gtctgctaca     5280

gcccacctcc agcaacggag aggtgtcctt tcaaagcgtc cgcgtgaaga tgatgatgga     5340

gaaccgagtg aacgcaaacg cgagagagat gagcgcagca aggacgggcg tgggggaaat     5400

aggagatagt ctagaccagg catcaaataa aacgaaaggc tcagtcgaaa gactgggcct     5460

ttcgttttat ctgttgtttg tcggtgaacg ctctctacta gagtcacact ggctcacctt     5520

cgggtgggcc tttctgcgtt tatagtacga tatcccaatg gcgcgccgag cttggctcga     5580

gcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata     5640

cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta     5700

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     5760

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctgttc cgcttcctcg     5820

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     5880

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     5940

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     6000

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     6060

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     6120

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     6180

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     6240

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     6300

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     6360

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     6420

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     6480

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     6540

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     6600

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     6660

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     6720

atatatgagt aaacttggtc tgacagttag aaaaactcat cgagcatcaa atgaaactgc     6780

aatttattca tatcaggatt atcaatacca tatttttgaa aaagccgttt ctgtaatgaa     6840

ggagaaaact caccgaggca gttccatagg atggcaagat cctggtatcg gtctgcgatt     6900

ccgactcgtc caacatcaat acaacctatt aatttcccct cgtcaaaaat aaggttatca     6960

agtgagaaat caccatgagt gacgactgaa tccggtgaga atggcaaaag tttatgcatt     7020

tctttccaga cttgttcaac aggccagcca ttacgctcgt catcaaaatc actcgcatca     7080

accaaaccgt tattcattcg tgattgcgcc tgagcgaaac gaaatacgcg atcgctgtta     7140

aaaggacaat tacaaacagg aatcgaatgc aaccggcgca ggaacactgc cagcgcatca     7200

acaatatttt cacctgaatc aggatattct tctaatacct ggaatgctgt tttcccaggg     7260

atcgcagtgg tgagtaacca tgcatcatca ggagtacgga taaaatgctt gatggtcgga     7320

agaggcataa attccgtcag ccagtttagt ctgaccatct catctgtaac atcattggca     7380

acgctacctt tgccatgttt cagaaacaac tctggcgcat cgggcttccc atacaatcga     7440

tagattgtcg cacctgattg cccgacatta tcgcgagccc atttataccc atataaatca     7500

gcatccatgt tggaatttaa tcgcggccta gagcaagacg tttcccgttg aatatggctc     7560

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga     7620

tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga     7680

aaagtgccac ctgacgtcta agaaaccatt attatcatga cattaaccta taaaaatagg     7740

cgtatcacga ggcccttttg tctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac     7800

atgcagctcc cggagactgt cacagcttgt ctgtaagcgg atgccgggag cagacaagcc     7860

cgtcagggcg cgtcagcggg tgttggcggg tgtcggggct ggcttaacta tgcggcatca     7920

gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg     7980

agaaaatacc gcatcaggcg ccattcgcca ttcaggctgc gcaactgttg ggaagggcga     8040

tcggtgcggg cctcttcgct attacgccag ctggcgaaag ggggatgtgc tgcaaggcga     8100

ttaagttggg taacgccagg gttttcccag tcacgacgtt gtaaaacgac ggccagtgaa     8160

ttgacgcgtt gcggctgcat gaaatcctgg ccggtttgtc tgatgccaag ctggcggcct     8220

ggccggccag cttggccgct gaagaaaccg agcgccgccg tctaaaaagg tgatgtgtat     8280

ttgagtaaaa cagcttgcgt catgcggtcg ctgcgtatat gatgcgatga gtaaataaac     8340

aaatacgcaa ggggaacgca tgaaggttat cgctgtactt aaccagaaag gcgggtcagg     8400

caagacgacc atcgcaaccc atctagcccg cgccctgcaa ctcgccgggg ccgatgttct     8460

gttagtcgat tccgatcccc agggcagtgc ccgcgattgg gcggccgtgc gggaagatca     8520

accgctaacc gttgtcggca tcgaccgccc gacgattgac cgcgacgtga aggccatcgg     8580

ccggcgcgac ttcgtagtga tcgacggagc gccccaggcg gcggacttgg ctgtgtccgc     8640

gatcaaggca gccgacttcg tgctgattcc ggtgcagcca agcccttacg acatatgggc     8700

caccgccgac ctggtggagc tggttaagca gcgcattgag gtcacggatg gaaggctaca     8760

agcggccttt gtcgtgtcgc gggcgatcaa aggcacgcgc atcggcggtg aggttgccga     8820

ggcgctggcc gggtacgagc tgcccattct tgagtcccgt atcacgcagc gcgtgagcta     8880

cccaggcact gccgccgccg gcacaaccgt tcttgaatca gaacccgagg gcgacgctgc     8940

ccgcgaggtc caggcgctgg ccgctgaaat taaatcaaaa ctcatttgag ttaatgaggt     9000

aaagagaaaa tgagcaaaag cacaaacacg ctaagtgccg gccgtccgag cgcacgcagc     9060

agcaaggctg caacgttggc cagcctggca gacacgccag ccatgaagcg ggtcaacttt     9120

cagttgccgg cggaggatca caccaagctg aagatgtacg cggtacgcca aggcaagacc     9180

attaccgagc tgctatctga atacatcgcg cagctaccag agtaaatgag caaatgaata     9240

aatgagtaga tgaattttag cggctaaagg aggcggcatg gaaaatcaag aacaaccagg     9300

caccgacgcc gtggaatgcc ccatgtgtgg aggaacgggc ggttggccag gcgtaagcgg     9360

ctgggttgtc tgccggccct gcaatggcac tggaaccccc aagcccgagg aatcggcgtg     9420

agcggtcgca aaccatccgg cccggtacaa atcggcgcgg cgctgggtga tgacctggtg     9480

gagaagttga aggccgcgca ggccgcccag cggcaacgca tcgaggcaga agcacgcccc     9540

ggtgaatcgt ggcaagcggc cgctgatcga atccgcaaag aatcccggca accgccggca     9600

gccggtgcgc cgtcgattag gaagccgccc aagggcgacg agcaaccaga ttttttcgtt     9660

ccgatgctct atgacgtggg cacccgcgat agtcgcagca tcatggacgt ggccgttttc     9720

cgtctgtcga agcgtgaccg acgagctggc gaggtgatcc gctacgagct tccagacggg     9780

cacgtagagg tttccgcagg gccggccggc atggccagtg tgtgggatta cgacctggta     9840

ctgatggcgg tttcccatct aaccgaatcc atgaaccgat accgggaagg gaagggagac     9900

aagcccggcc gcgtgttccg tccacacgtt gcggacgtac tcaagttctg ccggcgagcc     9960

gatggcggaa agcagaaaga cgacctggta gaaacctgca ttcggttaaa caccacgcac    10020

gttgccatgc agcgtacgaa gaaggccaag aacggccgcc tggtgacggt atccgagggt    10080

gaagccttga ttagccgcta caagatcgta aagagcgaaa ccgggcggcc ggagtacatc    10140

gagatcgagc tagctgattg gatgtaccgc gagatcacag aaggcaagaa cccggacgtg    10200

ctgacggttc accccgatta ctttttgatc gatcccggca tcggccgttt tctctaccgc    10260

ctggcacgcc gcgccgcagg caaggcagaa gccagatggt tgttcaagac gatctacgaa    10320

cgcagtggca gcgccggaga gttcaagaag ttctgtttca ccgtgcgcaa gctgatcggg    10380

tcaaatgacc tgccggagta cgatttgaag gaggaggcgg ggcaggctgg cccgatccta    10440

gtcatgcgct accgcaacct gatcgagggc gaagcatccg ccggttccta atgtacggag    10500

cagatgctag ggcaaattgc cctagcaggg gaaaaaggtc gaaaaggtct ctttcctgtg    10560

gatagcacgt acattgggaa cccaaagccg tacattggga accggaaccc gtacattggg    10620

aacccaaagc cgtacattgg gaaccggtca cacatgtaag tgactgatat aaaagagaaa    10680

aaaggcgatt tttccgccta aaactcttta aaacttatta aaactcttaa aacccgcctg    10740

gcctgtgcat atgctagtca tgccccgcgc ccac                                10774


<210>  127
<211>  12424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE2737 Full Plasmid Sequence

<400>  127
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg cctagctaac tagctagcca cgtgactcgc agaacgttgt     8160

gtggcgagac ggaaagaaag tcacgcctcc aaagagtgca gcatctcttc tggctctcac     8220

ggtcctctgt ggatccatcg atatcgaatt cctgcaggct cgaggtcatt catatgcttg     8280

agaagagagt cgggatagtc caaaataaaa caaaggtaag attacctggt caaaagtgaa     8340

aacatcagtt aaaaggtggt ataaagtaaa atatcggtaa taaaaggtgg cccaaagtga     8400

aatttactct tttctactat tataaaaatt gaggatgttt ttgtcggtac tttgatacgt     8460

catttttgta tgaattggtt tttaagttta ttcgcttttg gaaatgcata tctgtatttg     8520

agtcgggttt taagttcgtt tgcttttgta aatacagagg gatttgtata agaaatatct     8580

ttagaaaaac ccatatgcta atttgacata atttttgaga aaaatatata ttcaggcgaa     8640

ttctcacaat gaacaataat aagattaaaa tagctttccc ccgttgcagc gcatgggtat     8700

tttttctagt aaaaataaaa gataaactta gactcaaaac atttacaaaa acaaccccta     8760

aagttcctaa agcccaaagt gctatccacg atccatagca agcccagccc aacccaaccc     8820

aacccaaccc accccagtcc agccaactgg acaatagtct ccacaccccc ccactatcac     8880

cgtgagttgt ccgcacgcac cgcacgtctc gcagccaaaa aaaaaaagaa agaaaaaaaa     8940

gaaaaagaaa aaacagcagg tgggtccggg tcgtgggggc cggaaacgcg aggaggatcg     9000

cgagccagcg acgaggagct taggcctcat cgttgaagat gcctctgccg acagtggtcc     9060

caaagatgga cccccaccca cgaggagcat cgtggaaaaa gaagacgttc caaccacgtc     9120

ttcaaagcaa gtggattgat gtgatatctc cactgacgta agggatgacg cacaatccca     9180

ctatccttcg aggcctcatc gttgaagatg cctctgccga cagtggtccc aaagatggac     9240

ccccacccac gaggagcatc gtggaaaaag aagacgttcc aaccacgtct tcaaagcaag     9300

tggattgatg tgatatctcc actgacgtaa gggatgacgc acaatcccac tatccttcga     9360

agctccctcc ctccgcttcc aaagaaacgc cccccatcgc cactatatac ataccccccc     9420

ctctcctccc atccccccaa cccttctaga accatcttcc acacactcaa gccacactat     9480

tggagaacac acagggacaa cacaccataa gatccaaggg aggcctccgc cgccgccggt     9540

aaccaccccg cccctctcct ctttctttct ccgttttttt ttccgtctcg gtctcgatct     9600

ttggccttgg tagtttgggt gggcgagagg cggcttcgtg cgcgcccaga tcggtgcgcg     9660

ggaggggcgg gatctcgcgg ctggggctct cgccggcgtg gatccggccc ggatctcgcg     9720

gggaatgggg ctctcggatg tagatctgcg atccgccgtt gttgggggag atgatggggg     9780

gtttaaaatt tccgccgtgc taaacaagat caggaagagg ggaaaagggc actatggttt     9840

atatttttat atatttctgc tgcttcgtca ggcttagatg tgctagatct ttctttcttc     9900

tttttgtggg tagaatttga atccctcagc attgttcatc ggtagttttt cttttcatga     9960

tttgtgacaa atgcagcctc gtgcggagct tttttgtagg tagaaggcgg ccgcatggcc    10020

cagtctaagc acgggttgac gaaggagatg actatgaagt atcgcatgga aggctgcgtt    10080

gacggccaca aattcgtcat taccggcgag ggcatcggct acccctttaa ggtaagtttc    10140

tgcttctacc tttgatatat atataataat tatcattaat tagtagtaat ataatatttc    10200

aaatattttt ttcaaaataa aagaatgtag tatatagcaa ttgcttttct gtagtttata    10260

agtgtgtata ttttaattta taacttttct aatatatgac caaaatttgt tgatgtgcag    10320

ggcaagcaag cgataaacct gtgcgtggtg gagggtggcc ctctgccctt cgccgaggat    10380

atactctcag ccgccttcat gtacgggaat cgggtgttca cggagtaccc gcaagacatc    10440

gtggactact tcaagaactc ctgccccgcc ggatacacat gggaccgttc cttcctcttc    10500

gaggacggag ccgtttgcat ctgcaacgcg gacatcaccg tgtccgtcga ggagaactgc    10560

atgtaccacg agtcaaagtt ctatggagtg aacttcccgg ccgatggtcc cgtgatgaag    10620

aaaatgacgg acaactggga gccgtcgtgc gagaaaatca ttcccgtccc aaaacaggga    10680

atcctcaagg gcgacgtgtc gatgtaccta cttctcaagg acggtggacg gctacggtgc    10740

cagttcgaca ctgtttacaa ggcgaagtcg gtgccgagga agatgccgga ctggcacttt    10800

atccagcaca agctgacaag ggaggacaga agcgacgcta agaaccagaa atggcacctc    10860

accgagcacg ccatcgccag tggctctgcg ctgcccgggt gaccctgcaa tgtgacccta    10920

gacttgtcca tcttctggat tggccaactt aattaatgta tgaaataaaa ggatgcacac    10980

atagtgacat gctaatcact ataatgtggg catcaaagtt gtgtgttatg tgtaattact    11040

aattatctga ataagagaaa gagatcatcc atatttctta tcctaaatga atgtcacgtg    11100

tctttataat tctttgatga accagatgca ttttattaac caattccata tacatataaa    11160

tattaatcat atataattaa tatcaattgg gttagcaaaa caaatctagt ctaggtgtgt    11220

tttgctaatt attgggggat agtgcaaaaa gaaatctacg ttctcaataa ttcagataga    11280

aaacttaata aagtgagata atttacatag attgctttta tcctttgata tatgtgaaac    11340

catgcatgat ataaggaaaa tagatagaga aataattttt tacatcgttg aatatgtaaa    11400

caatttaatt caagaagcta ggaatataaa tattgaggag tttatgatta ttattattat    11460

tttgatgttc aatgaagttt tttttaattt catatgaagt atacaaaaat tcttcataga    11520

tttttgtttc tatgccgtag ttatctttaa tatatttgtg gttgaagaaa tttattgcta    11580

gaaacgaatg gattgtcaat ttttttttaa agcaaatata tatgaaatta tactgtatat    11640

tattttagtc atgattaaaa tgtggcctta attgaatcat ctttctcatt cattttttca    11700

aaagcatatc aggatgattg atatttatct attttaaaaa ttaatttaag ggttcaaatt    11760

aaatttaact taaaagtgtc ctaaccgtag ttaaaggttt actttaaaaa aatactatga    11820

aaaatctaat cttctatgaa tcgagggccc ggccgtgacg gccacgagcg aactcctgca    11880

ggcgataaaa atgttttaaa cgatatatat tataaaaaaa aacgtttcaa aaataaatac    11940

aaaaatgttt ttaaatatat ataatttaac tcattaaaga aaataaaaat gcaagtgcgg    12000

tgacaagaca agctaaaagt tgcaaaagaa atggcagggc tataaggctc acctactcct    12060

ggatttacca aattttggtt cgtccctata ctcgaaaaat aaaacaaaat aaatttcagt    12120

atcttcgttt ttgtatgctt tgactgtgag gcgaggccaa ctttcttctt ctgtctgaga    12180

tgaattttgt ttgcctcctg tgaaggatgt atcattcaaa gtgaatgttt tgcaactgcc    12240

agtagtccca catcgaccaa atattcttat tacagtgtgt ttatatagca cctggagaag    12300

gaatgggttg tttcaaagat taaataattt ctactaagtg tagattgccg ttaatttgag    12360

agtccaagta atttctacta agtgtagatt tttttttgcg gccgcacaac aaacgcgccg    12420

gcga                                                                 12424


<210>  128
<211>  7198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3106 Full Plasmid Sequence

<400>  128
cgcccaccgg aaggagctga ctgggttgaa ggctctcaag ggcatcggtc gagatcccgg       60

tgcctaatga gtgagctaac ttacattaat tgcgttgcgc cccgggatga gattatcaaa      120

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat      180

atatgtgtaa cattggtcta gtgattggat ccttgacagc tagctcagtc ctaggtactg      240

tgctagcgct agcaaagagg agaaaggtac catgagcaat tcaacaatta aaatcgcaac      300

aaggaagtac ctgggtaaac agaatgttta tgacatcggc gtggagcgtg atcacaattt      360

cgctttgaag aacggtttta ttgcgagcaa ctgcttcaac tccggtggaa gttccggagg      420

ttcaagcggg tctgaaacgc cgggcaccag cgagtcggcg accccggaaa gcagcggtgg      480

ttcttccggc ggtagcatgc ccgatcgagc tcaagttatc attcgcattg tgccgggagg      540

tggcaccaag acccttcaac aaattatcaa tcagttggag tatctatccc ggaagggcag      600

gctggagctg cagcgttcag cccgacatct cgatattccc ctgccaccgg atcaaatcca      660

cgaacttgcc cgaagctggg ttcaagagac tggaacttat gacgaaagtc agccagacga      720

ggaaaggcaa caggagttga ccacccatat tattgtaagc ttccccgccg gtacaagcca      780

ggtagcggct tatgcggcga gccgggagtg ggcagccgag atgtttgggt caggcgcagg      840

ggggggccga tacaactatc ttacggcctt ccacatcgat cgcgaccacc cacatctgca      900

tgtcgtcgtc aatcggcgcg aacttttagg acacggctgg ctgaagatat ctcggcgcca      960

tccccaactg aattacgacg ccctgcgcat aaagatggcc gagatttcac ttcgtcatgg     1020

cattgccctc gatgcgagcc gacgagcaga acgtggcatc accgagcggc cgatcactta     1080

tgcccaatat cggcgccttg agcgggagca ggctcgccaa atccgtttcg aagacgcgga     1140

tttggaacag tcgtcgccgc aaggagatca tccagaattc agccaacctt tcgatacatc     1200

cccatttgaa gcatccgcgg gcggaccgga ggacatgcct cggcccaaca atcggcagaa     1260

tgagtcgcaa gttcatctcc aggagccagc tggtgtcagc aacgaagccg gtgtccttgt     1320

gcgggttgca ttggaaacgg agcgccttgc tcaaccattc gtttccgaaa ccattctcgc     1380

ggacgacata gggagcggct cttcgcgtgt tgccgagggc cgtgtggaga gcgcaaaccg     1440

cactcccgat attcctcgcg cagcaactga agctgccacg cacacgacac acgaccggca     1500

gcggcgtgca aagcgtcctc atgatgacga cggagggccg agtggagcaa aacgtgtgac     1560

attggaaggc atcgcggttg ggccccaggc gaacgccggc gaacaggatg gcagtagtgg     1620

ccccttagta cggcaagctg gaacgtcacg gccatctcca ccgacggcca cgacgcgggc     1680

cagcaccgca accgattcat tgtctgctac agcccacctc cagcaacgga gaggtgtcct     1740

ttcaaagcgt ccgcgtgaag atgatgatgg agaaccgagt gaacgcaaac gcgagagaga     1800

tgagcgcagc aaggacgggc gtgggggaaa taggagatag tctagaccag gcatcaaata     1860

aaacgaaagg ctcagtcgaa agactgggcc tttcgtttta tctgttgttt gtcggtgaac     1920

gctctctact agagtcacac tggctcacct tcgggtgggc ctttctgcgt ttatagtacg     1980

atatcccaat ggcgcgccga gcttggctcg agcatggtca tagctgtttc ctgtgtgaaa     2040

ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg     2100

gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca     2160

gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg     2220

tttgcgtatt gggcgctgtt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg     2280

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg     2340

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa     2400

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     2460

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     2520

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     2580

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     2640

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     2700

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     2760

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     2820

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     2880

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     2940

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     3000

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     3060

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     3120

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     3180

gaaaaactca tcgagcatca aatgaaactg caatttattc atatcaggat tatcaatacc     3240

atatttttga aaaagccgtt tctgtaatga aggagaaaac tcaccgaggc agttccatag     3300

gatggcaaga tcctggtatc ggtctgcgat tccgactcgt ccaacatcaa tacaacctat     3360

taatttcccc tcgtcaaaaa taaggttatc aagtgagaaa tcaccatgag tgacgactga     3420

atccggtgag aatggcaaaa gtttatgcat ttctttccag acttgttcaa caggccagcc     3480

attacgctcg tcatcaaaat cactcgcatc aaccaaaccg ttattcattc gtgattgcgc     3540

ctgagcgaaa cgaaatacgc gatcgctgtt aaaaggacaa ttacaaacag gaatcgaatg     3600

caaccggcgc aggaacactg ccagcgcatc aacaatattt tcacctgaat caggatattc     3660

ttctaatacc tggaatgctg ttttcccagg gatcgcagtg gtgagtaacc atgcatcatc     3720

aggagtacgg ataaaatgct tgatggtcgg aagaggcata aattccgtca gccagtttag     3780

tctgaccatc tcatctgtaa catcattggc aacgctacct ttgccatgtt tcagaaacaa     3840

ctctggcgca tcgggcttcc catacaatcg atagattgtc gcacctgatt gcccgacatt     3900

atcgcgagcc catttatacc catataaatc agcatccatg ttggaattta atcgcggcct     3960

agagcaagac gtttcccgtt gaatatggct catactcttc ctttttcaat attattgaag     4020

catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa     4080

acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgtct aagaaaccat     4140

tattatcatg acattaacct ataaaaatag gcgtatcacg aggccctttt gtctcgcgcg     4200

tttcggtgat gacggtgaaa acctctgaca catgcagctc ccggagactg tcacagcttg     4260

tctgtaagcg gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg     4320

gtgtcggggc tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat     4380

gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gccattcgcc     4440

attcaggctg cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc tattacgcca     4500

gctggcgaaa gggggatgtg ctgcaaggcg attaagttgg gtaacgccag ggttttccca     4560

gtcacgacgt tgtaaaacga cggccagtga attgacgcgt tgcggctgca tgaaatcctg     4620

gccggtttgt ctgatgccaa gctggcggcc tggccggcca gcttggccgc tgaagaaacc     4680

gagcgccgcc gtctaaaaag gtgatgtgta tttgagtaaa acagcttgcg tcatgcggtc     4740

gctgcgtata tgatgcgatg agtaaataaa caaatacgca aggggaacgc atgaaggtta     4800

tcgctgtact taaccagaaa ggcgggtcag gcaagacgac catcgcaacc catctagccc     4860

gcgccctgca actcgccggg gccgatgttc tgttagtcga ttccgatccc cagggcagtg     4920

cccgcgattg ggcggccgtg cgggaagatc aaccgctaac cgttgtcggc atcgaccgcc     4980

cgacgattga ccgcgacgtg aaggccatcg gccggcgcga cttcgtagtg atcgacggag     5040

cgccccaggc ggcggacttg gctgtgtccg cgatcaaggc agccgacttc gtgctgattc     5100

cggtgcagcc aagcccttac gacatatggg ccaccgccga cctggtggag ctggttaagc     5160

agcgcattga ggtcacggat ggaaggctac aagcggcctt tgtcgtgtcg cgggcgatca     5220

aaggcacgcg catcggcggt gaggttgccg aggcgctggc cgggtacgag ctgcccattc     5280

ttgagtcccg tatcacgcag cgcgtgagct acccaggcac tgccgccgcc ggcacaaccg     5340

ttcttgaatc agaacccgag ggcgacgctg cccgcgaggt ccaggcgctg gccgctgaaa     5400

ttaaatcaaa actcatttga gttaatgagg taaagagaaa atgagcaaaa gcacaaacac     5460

gctaagtgcc ggccgtccga gcgcacgcag cagcaaggct gcaacgttgg ccagcctggc     5520

agacacgcca gccatgaagc gggtcaactt tcagttgccg gcggaggatc acaccaagct     5580

gaagatgtac gcggtacgcc aaggcaagac cattaccgag ctgctatctg aatacatcgc     5640

gcagctacca gagtaaatga gcaaatgaat aaatgagtag atgaatttta gcggctaaag     5700

gaggcggcat ggaaaatcaa gaacaaccag gcaccgacgc cgtggaatgc cccatgtgtg     5760

gaggaacggg cggttggcca ggcgtaagcg gctgggttgt ctgccggccc tgcaatggca     5820

ctggaacccc caagcccgag gaatcggcgt gagcggtcgc aaaccatccg gcccggtaca     5880

aatcggcgcg gcgctgggtg atgacctggt ggagaagttg aaggccgcgc aggccgccca     5940

gcggcaacgc atcgaggcag aagcacgccc cggtgaatcg tggcaagcgg ccgctgatcg     6000

aatccgcaaa gaatcccggc aaccgccggc agccggtgcg ccgtcgatta ggaagccgcc     6060

caagggcgac gagcaaccag attttttcgt tccgatgctc tatgacgtgg gcacccgcga     6120

tagtcgcagc atcatggacg tggccgtttt ccgtctgtcg aagcgtgacc gacgagctgg     6180

cgaggtgatc cgctacgagc ttccagacgg gcacgtagag gtttccgcag ggccggccgg     6240

catggccagt gtgtgggatt acgacctggt actgatggcg gtttcccatc taaccgaatc     6300

catgaaccga taccgggaag ggaagggaga caagcccggc cgcgtgttcc gtccacacgt     6360

tgcggacgta ctcaagttct gccggcgagc cgatggcgga aagcagaaag acgacctggt     6420

agaaacctgc attcggttaa acaccacgca cgttgccatg cagcgtacga agaaggccaa     6480

gaacggccgc ctggtgacgg tatccgaggg tgaagccttg attagccgct acaagatcgt     6540

aaagagcgaa accgggcggc cggagtacat cgagatcgag ctagctgatt ggatgtaccg     6600

cgagatcaca gaaggcaaga acccggacgt gctgacggtt caccccgatt actttttgat     6660

cgatcccggc atcggccgtt ttctctaccg cctggcacgc cgcgccgcag gcaaggcaga     6720

agccagatgg ttgttcaaga cgatctacga acgcagtggc agcgccggag agttcaagaa     6780

gttctgtttc accgtgcgca agctgatcgg gtcaaatgac ctgccggagt acgatttgaa     6840

ggaggaggcg gggcaggctg gcccgatcct agtcatgcgc taccgcaacc tgatcgaggg     6900

cgaagcatcc gccggttcct aatgtacgga gcagatgcta gggcaaattg ccctagcagg     6960

ggaaaaaggt cgaaaaggtc tctttcctgt ggatagcacg tacattggga acccaaagcc     7020

gtacattggg aaccggaacc cgtacattgg gaacccaaag ccgtacattg ggaaccggtc     7080

acacatgtaa gtgactgata taaaagagaa aaaaggcgat ttttccgcct aaaactcttt     7140

aaaacttatt aaaactctta aaacccgcct ggcctgtgca tatgctagtc atgccccg       7198


<210>  129
<211>  8260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3110 Full Plasmid Sequence

<400>  129
aaggagctga ctgggttgaa ggctctcaag ggcatcggtc gagatcccgg tgcctaatga       60

gtgagctaac ttacattaat tgcgttgcgc cccgggatga gattatcaaa aaggatcttc      120

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgtgtaa      180

cattggtcta gtgattggat ccttgacagc tagctcagtc ctaggtactg tgctagcgct      240

agcaaagagg agaaaggtac catgcccgat cgagctcaag ttatcattcg cattgtgccg      300

ggaggtggca ccaagaccct tcaacaaatt atcaatcagt tggagtatct atcccggaag      360

ggcaggctgg agctgcagcg ttcagcccga catctcgata ttcccctgcc accggatcaa      420

atccacgaac ttgcccgaag ctgggttcaa gagactggaa cttatgacga aagtcagcca      480

gacgaggaaa ggcaacagga gttgaccacc catattattg taagcttccc cgccggtaca      540

agccaggtag cggcttatgc ggcgagccgg gagtgggcag ccgagatgtt tgggtcaggc      600

gcaggggggg gccgatacaa ctatcttacg gccttccaca tcgatcgcga ccacccacat      660

ctgcatgtcg tcgtcaatcg gcgcgaactt ttaggacacg gctggctgaa gatatctcgg      720

cgccatcccc aactgaatta cgacgccctg cgcataaaga tggccgagat ttcacttcgt      780

catggcattg ccctcgatgc gagccgacga gcagaacgtg gcatcaccga gcggccgatc      840

acttatgccc aatatcggcg ccttgagcgg gagcaggctc gccaaatccg tttcgaagac      900

gcggatttgg aacagtcgtc gccgcaagga gatcatccag aattcagcca acctttcgat      960

acatccccat ttgaagcatc cgcgggcgga ccggaggaca tgcctcggcc caacaatcgg     1020

cagaatgagt cgcaagttca tctccaggag ccagctggtg tcagcaacga agccggtgtc     1080

cttgtgcggg ttgcattgga aacggagcgc cttgctcaac cattcgtttc cgaaaccatt     1140

ctcgcggacg acatagggag cggctcttcg cgtgttgccg agggccgtgt ggagagcgca     1200

aaccgcactc ccgatattcc tcgcgcagca actgaagctg ccacgcacac gacacacgac     1260

cggcagcggc gtgcaaagcg tcctcatgat gacgacggag ggccgagtgg agcaaaacgt     1320

gtgacattgg aaggcatcgc ggttgggccc caggcgaacg ccggcgaaca ggatggcagt     1380

agtggcccct tagtacggca agctggaacg tcacggccat ctccaccgac ggccacgacg     1440

cgggccagca ccgcaaccga ttcattgtct gctacagccc acctccagca acggagaggt     1500

gtcctttcaa agcgtccgcg tgaagatgat gatggagaac cgagtgaacg caaacgcgag     1560

agagatgagc gcagcaagga cgggcgtggg ggaaatagga gaagcggtgg ctcctcgggt     1620

ggcagcatga gcggatcaaa gaaaagaagg atcaagcaag atgaggaatt gctgagtaaa     1680

aactaccatc ttgagaacga agttgcccgt ctgaagaagg gtagcggttc gggcggtagc     1740

ggttccggag gtagcggcag cggctcgggt ggtagcggtt caggtggctc aggcagtggt     1800

gaagaattgc tgagcaaaaa ttatcacctg gagaatgaag ttgcgcgtct gaagaaaggc     1860

agcggctccg gtggttctgg ctcgggcggt tcaggtagtg gttccggtgg ctccggcagc     1920

ggtggttctg gctccggtga agagttgttg tccaagaatt atcatctgga aaacgaagtg     1980

gcaagactca agaagggttc gggttcgggc ggcagcggaa gtggtggtag cggaagcggc     2040

agcggcggct ccggctccgg tggctccggc agcggtgagg agctgctgag caagaactac     2100

cacttggaga acgaagtggc acgcctgaag aaaggtagcg gtagcggcgg ttctgggagc     2160

ggtggctccg gaagcggcag cggcggttcg ggttctggtg gcagcggtag cggcgaagag     2220

ctgcttagca aaaattatca ccttgagaac gaggtcgctc gcctgaaaaa aggttccggc     2280

agcggcggta gcggtagcgg tggcagcggt agcggcagcg gtggctcggg gtccggtggt     2340

agcggctccg gtgaagaatt gttgtccaaa aactaccacc tggagaatga agtggcgcgt     2400

ctgaaaaagg gtagcggcag cggtggtagc ggctctggag gtagcggctc cggtagtggc     2460

ggtagcgggt ctggcggctc tggttcaggc gaagaactgc tcagcaagaa ttaccatttg     2520

gagaacgagg ttgcgcgcct gaaaaagggc tctggtagcg gcggttctgg ctctggtggc     2580

agcgggagcg gctccggtgg cagcggctct ggaggttccg gttcgggtga ggagctgctg     2640

agcaagaact accacctgga aaacgaggtg gcgcgtctga aaaaaggcag caagaaacgt     2700

cgtatcaaac aggactccgg tggcagttcc ggtggcagca gtgcgtcgtt agcaagaggc     2760

ggtccaaatg cagtgggact cctaacgacg aacgaaagct ttgagaaaaa tatcaatgag     2820

gtctacaacc gtacgcgagc cgagctagac gcttcttcac gtgacagaag tcgctctgga     2880

ctatcgcgat aatctagacc aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg     2940

cctttcgttt tatctgttgt ttgtcggtga acgctctcta ctagagtcac actggctcac     3000

cttcgggtgg gcctttctgc gtttatagta cgatatccca atggcgcgcc gagcttggct     3060

cgagcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     3120

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     3180

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat     3240

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctg ttccgcttcc     3300

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     3360

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     3420

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     3480

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     3540

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     3600

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     3660

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     3720

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     3780

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     3840

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     3900

tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     3960

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     4020

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     4080

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     4140

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     4200

agtatatatg agtaaacttg gtctgacagt tagaaaaact catcgagcat caaatgaaac     4260

tgcaatttat tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat     4320

gaaggagaaa actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg     4380

attccgactc gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta     4440

tcaagtgaga aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc     4500

atttctttcc agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca     4560

tcaaccaaac cgttattcat tcgtgattgc gcctgagcga aacgaaatac gcgatcgctg     4620

ttaaaaggac aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca     4680

tcaacaatat tttcacctga atcaggatat tcttctaata cctggaatgc tgttttccca     4740

gggatcgcag tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc     4800

ggaagaggca taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg     4860

gcaacgctac ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat     4920

cgatagattg tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa     4980

tcagcatcca tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg     5040

ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc     5100

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     5160

cgaaaagtgc cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat     5220

aggcgtatca cgaggccctt ttgtctcgcg cgtttcggtg atgacggtga aaacctctga     5280

cacatgcagc tcccggagac tgtcacagct tgtctgtaag cggatgccgg gagcagacaa     5340

gcccgtcagg gcgcgtcagc gggtgttggc gggtgtcggg gctggcttaa ctatgcggca     5400

tcagagcaga ttgtactgag agtgcaccat atgcggtgtg aaataccgca cagatgcgta     5460

aggagaaaat accgcatcag gcgccattcg ccattcaggc tgcgcaactg ttgggaaggg     5520

cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg tgctgcaagg     5580

cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac gacggccagt     5640

gaattgacgc gttgcggctg catgaaatcc tggccggttt gtctgatgcc aagctggcgg     5700

cctggccggc cagcttggcc gctgaagaaa ccgagcgccg ccgtctaaaa aggtgatgtg     5760

tatttgagta aaacagcttg cgtcatgcgg tcgctgcgta tatgatgcga tgagtaaata     5820

aacaaatacg caaggggaac gcatgaaggt tatcgctgta cttaaccaga aaggcgggtc     5880

aggcaagacg accatcgcaa cccatctagc ccgcgccctg caactcgccg gggccgatgt     5940

tctgttagtc gattccgatc cccagggcag tgcccgcgat tgggcggccg tgcgggaaga     6000

tcaaccgcta accgttgtcg gcatcgaccg cccgacgatt gaccgcgacg tgaaggccat     6060

cggccggcgc gacttcgtag tgatcgacgg agcgccccag gcggcggact tggctgtgtc     6120

cgcgatcaag gcagccgact tcgtgctgat tccggtgcag ccaagccctt acgacatatg     6180

ggccaccgcc gacctggtgg agctggttaa gcagcgcatt gaggtcacgg atggaaggct     6240

acaagcggcc tttgtcgtgt cgcgggcgat caaaggcacg cgcatcggcg gtgaggttgc     6300

cgaggcgctg gccgggtacg agctgcccat tcttgagtcc cgtatcacgc agcgcgtgag     6360

ctacccaggc actgccgccg ccggcacaac cgttcttgaa tcagaacccg agggcgacgc     6420

tgcccgcgag gtccaggcgc tggccgctga aattaaatca aaactcattt gagttaatga     6480

ggtaaagaga aaatgagcaa aagcacaaac acgctaagtg ccggccgtcc gagcgcacgc     6540

agcagcaagg ctgcaacgtt ggccagcctg gcagacacgc cagccatgaa gcgggtcaac     6600

tttcagttgc cggcggagga tcacaccaag ctgaagatgt acgcggtacg ccaaggcaag     6660

accattaccg agctgctatc tgaatacatc gcgcagctac cagagtaaat gagcaaatga     6720

ataaatgagt agatgaattt tagcggctaa aggaggcggc atggaaaatc aagaacaacc     6780

aggcaccgac gccgtggaat gccccatgtg tggaggaacg ggcggttggc caggcgtaag     6840

cggctgggtt gtctgccggc cctgcaatgg cactggaacc cccaagcccg aggaatcggc     6900

gtgagcggtc gcaaaccatc cggcccggta caaatcggcg cggcgctggg tgatgacctg     6960

gtggagaagt tgaaggccgc gcaggccgcc cagcggcaac gcatcgaggc agaagcacgc     7020

cccggtgaat cgtggcaagc ggccgctgat cgaatccgca aagaatcccg gcaaccgccg     7080

gcagccggtg cgccgtcgat taggaagccg cccaagggcg acgagcaacc agattttttc     7140

gttccgatgc tctatgacgt gggcacccgc gatagtcgca gcatcatgga cgtggccgtt     7200

ttccgtctgt cgaagcgtga ccgacgagct ggcgaggtga tccgctacga gcttccagac     7260

gggcacgtag aggtttccgc agggccggcc ggcatggcca gtgtgtggga ttacgacctg     7320

gtactgatgg cggtttccca tctaaccgaa tccatgaacc gataccggga agggaaggga     7380

gacaagcccg gccgcgtgtt ccgtccacac gttgcggacg tactcaagtt ctgccggcga     7440

gccgatggcg gaaagcagaa agacgacctg gtagaaacct gcattcggtt aaacaccacg     7500

cacgttgcca tgcagcgtac gaagaaggcc aagaacggcc gcctggtgac ggtatccgag     7560

ggtgaagcct tgattagccg ctacaagatc gtaaagagcg aaaccgggcg gccggagtac     7620

atcgagatcg agctagctga ttggatgtac cgcgagatca cagaaggcaa gaacccggac     7680

gtgctgacgg ttcaccccga ttactttttg atcgatcccg gcatcggccg ttttctctac     7740

cgcctggcac gccgcgccgc aggcaaggca gaagccagat ggttgttcaa gacgatctac     7800

gaacgcagtg gcagcgccgg agagttcaag aagttctgtt tcaccgtgcg caagctgatc     7860

gggtcaaatg acctgccgga gtacgatttg aaggaggagg cggggcaggc tggcccgatc     7920

ctagtcatgc gctaccgcaa cctgatcgag ggcgaagcat ccgccggttc ctaatgtacg     7980

gagcagatgc tagggcaaat tgccctagca ggggaaaaag gtcgaaaagg tctctttcct     8040

gtggatagca cgtacattgg gaacccaaag ccgtacattg ggaaccggaa cccgtacatt     8100

gggaacccaa agccgtacat tgggaaccgg tcacacatgt aagtgactga tataaaagag     8160

aaaaaaggcg atttttccgc ctaaaactct ttaaaactta ttaaaactct taaaacccgc     8220

ctggcctgtg catatgctag tcatgccccg cgcccaccgg                           8260


<210>  130
<211>  7519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3113 Full Plasmid Sequence

<400>  130
cgcgcccacc ggaaggagct gactgggttg aaggctctca agggcatcgg tcgagatccc       60

ggtgcctaat gagtgagcta acttacatta attgcgttgc gccccgggat gagattatca      120

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt      180

atatatgtgt aacattggtc tagtgattgg atccttgaca gctagctcag tcctaggtac      240

tgtgctagcg ctagcaaaga ggagaaaggt accatgcccg atcgagctca agttatcatt      300

cgcattgtgc cgggaggtgg caccaagacc cttcaacaaa ttatcaatca gttggagtat      360

ctatcccgga agggcaggct ggagctgcag cgttcagccc gacatctcga tattcccctg      420

ccaccggatc aaatccacga acttgcccga agctgggttc aagagactgg aacttatgac      480

gaaagtcagc cagacgagga aaggcaacag gagttgacca cccatattat tgtaagcttc      540

cccgccggta caagccaggt agcggcttat gcggcgagcc gggagtgggc agccgagatg      600

tttgggtcag gcgcaggggg gggccgatac aactatctta cggccttcca catcgatcgc      660

gaccacccac atctgcatgt cgtcgtcaat cggcgcgaac ttttaggaca cggctggctg      720

aagatatctc ggcgccatcc ccaactgaat tacgacgccc tgcgcataaa gatggccgag      780

atttcacttc gtcatggcat tgccctcgat gcgagccgac gagcagaacg tggcatcacc      840

gagcggccga tcacttatgc ccaatatcgg cgccttgagc gggagcaggc tcgccaaatc      900

cgtttcgaag acgcggattt ggaacagtcg tcgccgcaag gagatcatcc agaattcagc      960

caacctttcg atacatcccc atttgaagca tccgcgggcg gaccggagga catgcctcgg     1020

cccaacaatc ggcagaatga gtcgcaagtt catctccagg agccagctgg tgtcagcaac     1080

gaagccggtg tccttgtgcg ggttgcattg gaaacggagc gccttgctca accattcgtt     1140

tccgaaacca ttctcgcgga cgacataggg agcggctctt cgcgtgttgc cgagggccgt     1200

gtggagagcg caaaccgcac tcccgatatt cctcgcgcag caactgaagc tgccacgcac     1260

acgacacacg accggcagcg gcgtgcaaag cgtcctcatg atgacgacgg agggccgagt     1320

ggagcaaaac gtgtgacatt ggaaggcatc gcggttgggc cccaggcgaa cgccggcgaa     1380

caggatggca gtagtggccc cttagtacgg caagctggaa cgtcacggcc atctccaccg     1440

acggccacga cgcgggccag caccgcaacc gattcattgt ctgctacagc ccacctccag     1500

caacggagag gtgtcctttc aaagcgtccg cgtgaagatg atgatggaga accgagtgaa     1560

cgcaaacgcg agagagatga gcgcagcaag gacgggcgtg ggggaaatag gagaagcggt     1620

ggctcctcgg gtggcagcat gagcggatca aagaaaagaa ggatcaagca agatggctct     1680

tgtctgagct atgaaaccga aatcctcact gtagagtatg gtttgctgcc gatcggcaag     1740

atcgtggaga aacgtattga gtgcaccgtc tactccgtgg acaacaacgg taatatttac     1800

acccagccgg ttgctcagtg gcacgaccgc ggtgaacaag aggttttcga gtactgcttg     1860

gaagatggta gcctgattcg cgcgaccaaa gatcataagt ttatgacggt ggacggccaa     1920

atgctgccga ttgatgaaat cttcgaacgt gaactggatc tgatgcgtgt tgacaacctg     1980

ccaaattccg gtggcagttc cggtggcagc agtgcgtcgt tagcaagagg cggtccaaat     2040

gcagtgggac tcctaacgac gaacgaaagc tttgagaaaa atatcaatga ggtctacaac     2100

cgtacgcgag ccgagctaga cgcttcttca cgtgacagaa gtcgctctgg actatcgcga     2160

taatctagac caggcatcaa ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt     2220

ttatctgttg tttgtcggtg aacgctctct actagagtca cactggctca ccttcgggtg     2280

ggcctttctg cgtttatagt acgatatccc aatggcgcgc cgagcttggc tcgagcatgg     2340

tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc     2400

ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg     2460

ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaatgaatc     2520

ggccaacgcg cggggagagg cggtttgcgt attgggcgct gttccgcttc ctcgctcact     2580

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     2640

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     2700

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     2760

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     2820

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     2880

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     2940

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     3000

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     3060

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     3120

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     3180

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     3240

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     3300

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     3360

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     3420

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     3480

gagtaaactt ggtctgacag ttagaaaaac tcatcgagca tcaaatgaaa ctgcaattta     3540

ttcatatcag gattatcaat accatatttt tgaaaaagcc gtttctgtaa tgaaggagaa     3600

aactcaccga ggcagttcca taggatggca agatcctggt atcggtctgc gattccgact     3660

cgtccaacat caatacaacc tattaatttc ccctcgtcaa aaataaggtt atcaagtgag     3720

aaatcaccat gagtgacgac tgaatccggt gagaatggca aaagtttatg catttctttc     3780

cagacttgtt caacaggcca gccattacgc tcgtcatcaa aatcactcgc atcaaccaaa     3840

ccgttattca ttcgtgattg cgcctgagcg aaacgaaata cgcgatcgct gttaaaagga     3900

caattacaaa caggaatcga atgcaaccgg cgcaggaaca ctgccagcgc atcaacaata     3960

ttttcacctg aatcaggata ttcttctaat acctggaatg ctgttttccc agggatcgca     4020

gtggtgagta accatgcatc atcaggagta cggataaaat gcttgatggt cggaagaggc     4080

ataaattccg tcagccagtt tagtctgacc atctcatctg taacatcatt ggcaacgcta     4140

cctttgccat gtttcagaaa caactctggc gcatcgggct tcccatacaa tcgatagatt     4200

gtcgcacctg attgcccgac attatcgcga gcccatttat acccatataa atcagcatcc     4260

atgttggaat ttaatcgcgg cctagagcaa gacgtttccc gttgaatatg gctcatactc     4320

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     4380

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     4440

ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc     4500

acgaggccct tttgtctcgc gcgtttcggt gatgacggtg aaaacctctg acacatgcag     4560

ctcccggaga ctgtcacagc ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag     4620

ggcgcgtcag cgggtgttgg cgggtgtcgg ggctggctta actatgcggc atcagagcag     4680

attgtactga gagtgcacca tatgcggtgt gaaataccgc acagatgcgt aaggagaaaa     4740

taccgcatca ggcgccattc gccattcagg ctgcgcaact gttgggaagg gcgatcggtg     4800

cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag gcgattaagt     4860

tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag tgaattgacg     4920

cgttgcggct gcatgaaatc ctggccggtt tgtctgatgc caagctggcg gcctggccgg     4980

ccagcttggc cgctgaagaa accgagcgcc gccgtctaaa aaggtgatgt gtatttgagt     5040

aaaacagctt gcgtcatgcg gtcgctgcgt atatgatgcg atgagtaaat aaacaaatac     5100

gcaaggggaa cgcatgaagg ttatcgctgt acttaaccag aaaggcgggt caggcaagac     5160

gaccatcgca acccatctag cccgcgccct gcaactcgcc ggggccgatg ttctgttagt     5220

cgattccgat ccccagggca gtgcccgcga ttgggcggcc gtgcgggaag atcaaccgct     5280

aaccgttgtc ggcatcgacc gcccgacgat tgaccgcgac gtgaaggcca tcggccggcg     5340

cgacttcgta gtgatcgacg gagcgcccca ggcggcggac ttggctgtgt ccgcgatcaa     5400

ggcagccgac ttcgtgctga ttccggtgca gccaagccct tacgacatat gggccaccgc     5460

cgacctggtg gagctggtta agcagcgcat tgaggtcacg gatggaaggc tacaagcggc     5520

ctttgtcgtg tcgcgggcga tcaaaggcac gcgcatcggc ggtgaggttg ccgaggcgct     5580

ggccgggtac gagctgccca ttcttgagtc ccgtatcacg cagcgcgtga gctacccagg     5640

cactgccgcc gccggcacaa ccgttcttga atcagaaccc gagggcgacg ctgcccgcga     5700

ggtccaggcg ctggccgctg aaattaaatc aaaactcatt tgagttaatg aggtaaagag     5760

aaaatgagca aaagcacaaa cacgctaagt gccggccgtc cgagcgcacg cagcagcaag     5820

gctgcaacgt tggccagcct ggcagacacg ccagccatga agcgggtcaa ctttcagttg     5880

ccggcggagg atcacaccaa gctgaagatg tacgcggtac gccaaggcaa gaccattacc     5940

gagctgctat ctgaatacat cgcgcagcta ccagagtaaa tgagcaaatg aataaatgag     6000

tagatgaatt ttagcggcta aaggaggcgg catggaaaat caagaacaac caggcaccga     6060

cgccgtggaa tgccccatgt gtggaggaac gggcggttgg ccaggcgtaa gcggctgggt     6120

tgtctgccgg ccctgcaatg gcactggaac ccccaagccc gaggaatcgg cgtgagcggt     6180

cgcaaaccat ccggcccggt acaaatcggc gcggcgctgg gtgatgacct ggtggagaag     6240

ttgaaggccg cgcaggccgc ccagcggcaa cgcatcgagg cagaagcacg ccccggtgaa     6300

tcgtggcaag cggccgctga tcgaatccgc aaagaatccc ggcaaccgcc ggcagccggt     6360

gcgccgtcga ttaggaagcc gcccaagggc gacgagcaac cagatttttt cgttccgatg     6420

ctctatgacg tgggcacccg cgatagtcgc agcatcatgg acgtggccgt tttccgtctg     6480

tcgaagcgtg accgacgagc tggcgaggtg atccgctacg agcttccaga cgggcacgta     6540

gaggtttccg cagggccggc cggcatggcc agtgtgtggg attacgacct ggtactgatg     6600

gcggtttccc atctaaccga atccatgaac cgataccggg aagggaaggg agacaagccc     6660

ggccgcgtgt tccgtccaca cgttgcggac gtactcaagt tctgccggcg agccgatggc     6720

ggaaagcaga aagacgacct ggtagaaacc tgcattcggt taaacaccac gcacgttgcc     6780

atgcagcgta cgaagaaggc caagaacggc cgcctggtga cggtatccga gggtgaagcc     6840

ttgattagcc gctacaagat cgtaaagagc gaaaccgggc ggccggagta catcgagatc     6900

gagctagctg attggatgta ccgcgagatc acagaaggca agaacccgga cgtgctgacg     6960

gttcaccccg attacttttt gatcgatccc ggcatcggcc gttttctcta ccgcctggca     7020

cgccgcgccg caggcaaggc agaagccaga tggttgttca agacgatcta cgaacgcagt     7080

ggcagcgccg gagagttcaa gaagttctgt ttcaccgtgc gcaagctgat cgggtcaaat     7140

gacctgccgg agtacgattt gaaggaggag gcggggcagg ctggcccgat cctagtcatg     7200

cgctaccgca acctgatcga gggcgaagca tccgccggtt cctaatgtac ggagcagatg     7260

ctagggcaaa ttgccctagc aggggaaaaa ggtcgaaaag gtctctttcc tgtggatagc     7320

acgtacattg ggaacccaaa gccgtacatt gggaaccgga acccgtacat tgggaaccca     7380

aagccgtaca ttgggaaccg gtcacacatg taagtgactg atataaaaga gaaaaaaggc     7440

gatttttccg cctaaaactc tttaaaactt attaaaactc ttaaaacccg cctggcctgt     7500

gcatatgcta gtcatgccc                                                  7519


<210>  131
<211>  18607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3094 Full Plasmid Sequence

<400>  131
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cgtccaagct ggagaagttt acaaactgtt acagcctctc caaaaccctc aggtttaaag     9780

cgatcccggt gggcaagacc caggagaaca tcgacaacaa gaggctcctg gtggaagacg     9840

agaagcgcgc cgaagactac aagggcgtga agaagctgct cgataggtac tacctcagct     9900

ttattaacga cgtgctgcac agcatcaaac tcaagaatct caacaactac atctccctct     9960

tccgcaaaaa gacccgcacc gagaaggaga acaaggagct ggagaacctg gagatcaacc    10020

tccgcaagga aatcgccaaa gcgttcaagg gcaatgaagg gtacaagagc ctcttcaaga    10080

aagacatcat cgaaactatc ctcccagagt ttctcgatga caaggacgag atcgcgctgg    10140

tgaactcctt taacgggttc acaaccgcgt ttaccggctt ctttgataac agggaaaata    10200

tgttctccga ggaggccaag tccaccagca tcgccttcag gtgtatcaac gagaacctca    10260

cccgctacat ttccaatatg gacattttcg agaaggtgga tgcgatcttc gataagcacg    10320

aggtgcagga gatcaaagag aagattctca attccgatta tgacgtcgag gatttcttcg    10380

aaggggagtt ctttaatttt gtgctcacac aagagggcat tgacgtgtac aacgcgatta    10440

tcgggggctt cgtcacagag tccggggaga agattaaggg gctgaatgag tacatcaatc    10500

tgtacaatca gaagaccaag cagaaactgc cgaaattcaa gccgctctac aagcaagtcc    10560

tgtccgatag ggaaagcctc tccttctacg gcgagggcta taccagcgac gaggaggtgc    10620

tggaagtctt ccgcaacaca ctgaataaga atagcgagat tttctcctcc atcaagaagc    10680

tcgagaagct ctttaagaac tttgacgagt acagctccgc cgggattttc gtgaagaacg    10740

ggccggcgat cagcaccatc tccaaggaca tctttggcga gtggaacgtc atcagggaca    10800

agtggaacgc cgagtacgac gacatccacc tgaagaagaa ggcggtggtg accgagaagt    10860

atgaggacga tcgcaggaag tccttcaaaa aaatcggctc cttcagcctc gaacagctcc    10920

aggagtatgc cgatgcggat ctgtccgtcg tcgagaagct gaaggaaatc atcattcaga    10980

aggtcgacga gatctataaa gtgtacgggt ccagcgagaa gctgttcgac gccgactttg    11040

tgctcgagaa gtccctcaaa aagaatgacg ccgtggtggc cattatgaaa gacctgctcg    11100

actccgtgaa gtccttcgaa aattacatta aagcgttctt tggggagggg aaggaaacta    11160

acagggatga gtccttctat ggcgactttg tcctcgcgta cgacatcctg ctgaaggtcg    11220

accacattta cgacgcgatc cgcaactacg tgacacagaa gccgtactcc aaagacaagt    11280

tcaagctgta cttccagaac ccgcaattta tggggggctg ggacaaggat aaagagacag    11340

actaccgcgc gacaattctc cgctatggct ccaaatacta tctggccatc atggacaaga    11400

agtacgcgaa gtgcctgcag aagatcgaca aagacgacgt caatggcaac tatgaaaaga    11460

tcaactacaa gctgctgccg ggtccgaaca agatgctccc gaaggtgttc ttcagcaaga    11520

agtggatggc ctactacaat ccaagcgagg atattcagaa aatctataaa aacgggacct    11580

tcaagaaggg ggacatgttt aacctcaacg actgccacaa gctcattgat ttcttcaagg    11640

atagcatttc ccgctacccg aaatggtcca atgcgtacga ttttaacttc tccgagacag    11700

aaaagtacaa agacatcgcg ggcttttaca gggaggtgga ggagcaaggg tataaagttt    11760

cttttgaatc cgcgagcaag aaggaagtcg acaagctcgt cgaggagggc aagctctaca    11820

tgttccaaat ttataacaag gacttttccg acaagagcca tgggacccca aacctccaca    11880

ccatgtactt caaactgctc tttgacgaga acaaccacgg gcaaatcagg ctgagcggcg    11940

gcgccgaatt attcatgcgc agggcctccc tcaagaagga agagctggtc gtccatccag    12000

ccaattcccc gatcgcgaac aagaacccgg acaatccgaa aaagaccacc accctgtcct    12060

acgacgtcta caaggacaaa cgcttcagcg aagaccagta cgaattacac atcccaattg    12120

cgattaataa gtgcccaaag aatatcttca aaattaatac agaggtcagg gtgctgctca    12180

aacacgacga caatccgtat gtcatcggca ttgacagggg cgagcgcaat ctgctctata    12240

tcgtggtcgt ggatgggaag ggcaatattg tggagcagta ctccctgaac gagattatca    12300

acaacttcaa tgggattagg attaagaccg actatcacag cctgctcgac aagaaagaaa    12360

aagagaggtt tgaggcccgc caaaactgga cctccattga gaatatcaaa gaattaaagg    12420

ccggctatat ttcccaagtc gtccacaaga tctgcgagct ggtggagaaa tatgacgccg    12480

tgattgcgct cgaagactta aattctgggt tcaagaactc ccgcgtgaag gtggaaaaac    12540

aggtgtatca gaaattcgag aaaatgctga tcgacaaact caattatatg gtggataaga    12600

agtccaaccc gtgtgccaca gggggcgcgc tgaagggcta tcagatcacc aacaagttcg    12660

agagcttcaa gagcatgagc acccagaacg ggtttatttt ctacatcccg gcgtggctca    12720

cctccaagat tgacccgagc accggcttcg tgaacctcct gaagacaaag tatacctcca    12780

ttgccgacag caagaagttt atctcctcct tcgaccgcat tatgtatgtg ccggaggagg    12840

acctcttcga gttcgccctc gactacaaaa acttcagccg cacagatgcg gattacatca    12900

agaagtggaa gctgtactcc tacgggaaca ggatccgcat cttcaggaat ccaaaaaaaa    12960

ataacgtctt tgactgggag gaagtgtgcc tgacatccgc ctacaaggaa ctgttcaata    13020

aatacggcat caattaccag cagggcgaca ttcgcgccct cctctgtgag cagtccgaca    13080

aagcgtttta ctccagcttc atggccctca tgtccctgat gctccaaatg aggaatagca    13140

tcacagggcg caccgacgtc gacttcctca tcagcccggt gaagaactcc gacgggatct    13200

tttacgactc ccgcaactat gaggcgcaag agaatgcgat cctcccgaag aacgccgatg    13260

cgaacggggc ctataatatc gccaggaaag tgctctgggc catcgggcag ttcaaaaagg    13320

cggaggatga gaagctcgac aaggtgaaaa ttgccatttc caacaaggag tggctggagt    13380

acgcgcagac ctccgtgaag cacggctcct ccgagacacc aggcacctcc gagagcgcga    13440

cgcccgaggg cggctccggc ggctccggca gctgtttgag ttatgaaact gagatcctca    13500

ccgttgaata tggtctgtta cccattggaa aaattgttga gaagaggatt gaatgcacgg    13560

tctactctgt agacaacaat ggaaacatat acactcagcc tgtggctcag tggcatgata    13620

gaggggagca agaagttttt gagtattgtc ttgaagatgg ctcactaatc cgtgcaacaa    13680

aagatcacaa gttcatgaca gttgatggtc aaatgcttcc tattgatgaa atatttgaaa    13740

gagagcttga tttgatgagg gtggacaatt tgccaaattg aaagggctct ctgtcatgat    13800

ttcatacttt cattattgag ctctgtaatt acaattatga ccatgagaac atctcttatt    13860

gtgtggcctt ttaattgctg atgttagtac tgaaccaaag cttatcgtga tgatgtaaaa    13920

gcaataagta cttgtttgta gcttctttgt gtctcccttt gggcttaata catctgttta    13980

gtgttgtggc tttggcatag acttctcttg gtaataatgc cttgcaatgc aaaatttcaa    14040

ttatcaaatt ctattatgtt ctcaccttat ggtaacagct taccctgtgg aagatgagat    14100

tcttgagttg agtcattgcc aatttttggc attagctttt gaattagtga attttgacaa    14160

aaattaccgt gacactgatt ttgttgaagc tcttaagtgt agtttttaca aaatttcagt    14220

ggctcgttgt gattatgtca aactcacggc gaatgtagtt cttacagaat ttcagtggct    14280

ccctgcagga tcccaatggc gcgcctagct aactagctag ccacgtgact cgcagaacgt    14340

tgtgtggcga gacggaaaga aagtcacgcc tccaaagagt gcagcatctc ttctggctct    14400

cacggtcctc tgtggatcca tcgatatcga attcctgcag gctcgaggtc attcatatgc    14460

ttgagaagag agtcgggata gtccaaaata aaacaaaggt aagattacct ggtcaaaagt    14520

gaaaacatca gttaaaaggt ggtataaagt aaaatatcgg taataaaagg tggcccaaag    14580

tgaaatttac tcttttctac tattataaaa attgaggatg tttttgtcgg tactttgata    14640

cgtcattttt gtatgaattg gtttttaagt ttattcgctt ttggaaatgc atatctgtat    14700

ttgagtcggg ttttaagttc gtttgctttt gtaaatacag agggatttgt ataagaaata    14760

tctttagaaa aacccatatg ctaatttgac ataatttttg agaaaaatat atattcaggc    14820

gaattctcac aatgaacaat aataagatta aaatagcttt cccccgttgc agcgcatggg    14880

tattttttct agtaaaaata aaagataaac ttagactcaa aacatttaca aaaacaaccc    14940

ctaaagttcc taaagcccaa agtgctatcc acgatccata gcaagcccag cccaacccaa    15000

cccaacccaa cccaccccag tccagccaac tggacaatag tctccacacc cccccactat    15060

caccgtgagt tgtccgcacg caccgcacgt ctcgcagcca aaaaaaaaaa gaaagaaaaa    15120

aaagaaaaag aaaaaacagc aggtgggtcc gggtcgtggg ggccggaaac gcgaggagga    15180

tcgcgagcca gcgacgagga gcttaggcct catcgttgaa gatgcctctg ccgacagtgg    15240

tcccaaagat ggacccccac ccacgaggag catcgtggaa aaagaagacg ttccaaccac    15300

gtcttcaaag caagtggatt gatgtgatat ctccactgac gtaagggatg acgcacaatc    15360

ccactatcct tcgaggcctc atcgttgaag atgcctctgc cgacagtggt cccaaagatg    15420

gacccccacc cacgaggagc atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc    15480

aagtggattg atgtgatatc tccactgacg taagggatga cgcacaatcc cactatcctt    15540

cgaagctccc tccctccgct tccaaagaaa cgccccccat cgccactata tacatacccc    15600

cccctctcct cccatccccc caacccttct agaaccatct tccacacact caagccacac    15660

tattggagaa cacacaggga caacacacca taagatccaa gggaggcctc cgccgccgcc    15720

ggtaaccacc ccgcccctct cctctttctt tctccgtttt tttttccgtc tcggtctcga    15780

tctttggcct tggtagtttg ggtgggcgag aggcggcttc gtgcgcgccc agatcggtgc    15840

gcgggagggg cgggatctcg cggctggggc tctcgccggc gtggatccgg cccggatctc    15900

gcggggaatg gggctctcgg atgtagatct gcgatccgcc gttgttgggg gagatgatgg    15960

ggggtttaaa atttccgccg tgctaaacaa gatcaggaag aggggaaaag ggcactatgg    16020

tttatatttt tatatatttc tgctgcttcg tcaggcttag atgtgctaga tctttctttc    16080

ttctttttgt gggtagaatt tgaatccctc agcattgttc atcggtagtt tttcttttca    16140

tgatttgtga caaatgcagc ctcgtgcgga gcttttttgt aggtagaagg cggccgcatg    16200

gcccagtcta agcacgggtt gacgaaggag atgactatga agtatcgcat ggaaggctgc    16260

gttgacggcc acaaattcgt cattaccggc gagggcatcg gctacccctt taaggtaagt    16320

ttctgcttct acctttgata tatatataat aattatcatt aattagtagt aatataatat    16380

ttcaaatatt tttttcaaaa taaaagaatg tagtatatag caattgcttt tctgtagttt    16440

ataagtgtgt atattttaat ttataacttt tctaatatat gaccaaaatt tgttgatgtg    16500

cagggcaagc aagcgataaa cctgtgcgtg gtggagggtg gccctctgcc cttcgccgag    16560

gatatactct cagccgcctt catgtacggg aatcgggtgt tcacggagta cccgcaagac    16620

atcgtggact acttcaagaa ctcctgcccc gccggataca catgggaccg ttccttcctc    16680

ttcgaggacg gagccgtttg catctgcaac gcggacatca ccgtgtccgt cgaggagaac    16740

tgcatgtacc acgagtcaaa gttctatgga gtgaacttcc cggccgatgg tcccgtgatg    16800

aagaaaatga cggacaactg ggagccgtcg tgcgagaaaa tcattcccgt cccaaaacag    16860

ggaatcctca agggcgacgt gtcgatgtac ctacttctca aggacggtgg acggctacgg    16920

tgccagttcg acactgttta caaggcgaag tcggtgccga ggaagatgcc ggactggcac    16980

tttatccagc acaagctgac aagggaggac agaagcgacg ctaagaacca gaaatggcac    17040

ctcaccgagc acgccatcgc cagtggctct gcgctgcccg ggtgaccctg caatgtgacc    17100

ctagacttgt ccatcttctg gattggccaa cttaattaat gtatgaaata aaaggatgca    17160

cacatagtga catgctaatc actataatgt gggcatcaaa gttgtgtgtt atgtgtaatt    17220

actaattatc tgaataagag aaagagatca tccatatttc ttatcctaaa tgaatgtcac    17280

gtgtctttat aattctttga tgaaccagat gcattttatt aaccaattcc atatacatat    17340

aaatattaat catatataat taatatcaat tgggttagca aaacaaatct agtctaggtg    17400

tgttttgcta attattgggg gatagtgcaa aaagaaatct acgttctcaa taattcagat    17460

agaaaactta ataaagtgag ataatttaca tagattgctt ttatcctttg atatatgtga    17520

aaccatgcat gatataagga aaatagatag agaaataatt ttttacatcg ttgaatatgt    17580

aaacaattta attcaagaag ctaggaatat aaatattgag gagtttatga ttattattat    17640

tattttgatg ttcaatgaag ttttttttaa tttcatatga agtatacaaa aattcttcat    17700

agatttttgt ttctatgccg tagttatctt taatatattt gtggttgaag aaatttattg    17760

ctagaaacga atggattgtc aatttttttt taaagcaaat atatatgaaa ttatactgta    17820

tattatttta gtcatgatta aaatgtggcc ttaattgaat catctttctc attcattttt    17880

tcaaaagcat atcaggatga ttgatattta tctattttaa aaattaattt aagggttcaa    17940

attaaattta acttaaaagt gtcctaaccg tagttaaagg tttactttaa aaaaatacta    18000

tgaaaaatct aatcttctat gaatcgaggg cccggccgtg acggccacga gcgaactcct    18060

gcaggcgata aaaatgtttt aaacgatata tattataaaa aaaaacgttt caaaaataaa    18120

tacaaaaatg tttttaaata tatataattt aactcattaa agaaaataaa aatgcaagtg    18180

cggtgacaag acaagctaaa agttgcaaaa gaaatggcag ggctataagg ctcacctact    18240

cctggattta ccaaattttg gttcgtccct atactcgaaa aataaaacaa aataaatttc    18300

agtatcttcg tttttgtatg ctttgactgt gaggcgaggc caactttctt cttctgtctg    18360

agatgaattt tgtttgcctc ctgtgaagga tgtatcattc aaagtgaatg ttttgcaact    18420

gccagtagtc ccacatcgac caaatattct tattacagtg tgtttatata gcacctggag    18480

aaggaatggg ttgtttcaaa gattaaataa tttctactaa gtgtagattg ccgttaattt    18540

gagagtccaa gtaatttcta ctaagtgtag attttttttt gcggccgcac aacaaacgcg    18600

ccggcga                                                              18607


<210>  132
<211>  18505
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3096 Full Plasmid Sequence

<400>  132
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cgtccaagct ggagaagttt acaaactgtt acagcctctc caaaaccctc aggtttaaag     9780

cgatcccggt gggcaagacc caggagaaca tcgacaacaa gaggctcctg gtggaagacg     9840

agaagcgcgc cgaagactac aagggcgtga agaagctgct cgataggtac tacctcagct     9900

ttattaacga cgtgctgcac agcatcaaac tcaagaatct caacaactac atctccctct     9960

tccgcaaaaa gacccgcacc gagaaggaga acaaggagct ggagaacctg gagatcaacc    10020

tccgcaagga aatcgccaaa gcgttcaagg gcaatgaagg gtacaagagc ctcttcaaga    10080

aagacatcat cgaaactatc ctcccagagt ttctcgatga caaggacgag atcgcgctgg    10140

tgaactcctt taacgggttc acaaccgcgt ttaccggctt ctttgataac agggaaaata    10200

tgttctccga ggaggccaag tccaccagca tcgccttcag gtgtatcaac gagaacctca    10260

cccgctacat ttccaatatg gacattttcg agaaggtgga tgcgatcttc gataagcacg    10320

aggtgcagga gatcaaagag aagattctca attccgatta tgacgtcgag gatttcttcg    10380

aaggggagtt ctttaatttt gtgctcacac aagagggcat tgacgtgtac aacgcgatta    10440

tcgggggctt cgtcacagag tccggggaga agattaaggg gctgaatgag tacatcaatc    10500

tgtacaatca gaagaccaag cagaaactgc cgaaattcaa gccgctctac aagcaagtcc    10560

tgtccgatag ggaaagcctc tccttctacg gcgagggcta taccagcgac gaggaggtgc    10620

tggaagtctt ccgcaacaca ctgaataaga atagcgagat tttctcctcc atcaagaagc    10680

tcgagaagct ctttaagaac tttgacgagt acagctccgc cgggattttc gtgaagaacg    10740

ggccggcgat cagcaccatc tccaaggaca tctttggcga gtggaacgtc atcagggaca    10800

agtggaacgc cgagtacgac gacatccacc tgaagaagaa ggcggtggtg accgagaagt    10860

atgaggacga tcgcaggaag tccttcaaaa aaatcggctc cttcagcctc gaacagctcc    10920

aggagtatgc cgatgcggat ctgtccgtcg tcgagaagct gaaggaaatc atcattcaga    10980

aggtcgacga gatctataaa gtgtacgggt ccagcgagaa gctgttcgac gccgactttg    11040

tgctcgagaa gtccctcaaa aagaatgacg ccgtggtggc cattatgaaa gacctgctcg    11100

actccgtgaa gtccttcgaa aattacatta aagcgttctt tggggagggg aaggaaacta    11160

acagggatga gtccttctat ggcgactttg tcctcgcgta cgacatcctg ctgaaggtcg    11220

accacattta cgacgcgatc cgcaactacg tgacacagaa gccgtactcc aaagacaagt    11280

tcaagctgta cttccagaac ccgcaattta tggggggctg ggacaaggat aaagagacag    11340

actaccgcgc gacaattctc cgctatggct ccaaatacta tctggccatc atggacaaga    11400

agtacgcgaa gtgcctgcag aagatcgaca aagacgacgt caatggcaac tatgaaaaga    11460

tcaactacaa gctgctgccg ggtccgaaca agatgctccc gaaggtgttc ttcagcaaga    11520

agtggatggc ctactacaat ccaagcgagg atattcagaa aatctataaa aacgggacct    11580

tcaagaaggg ggacatgttt aacctcaacg actgccacaa gctcattgat ttcttcaagg    11640

atagcatttc ccgctacccg aaatggtcca atgcgtacga ttttaacttc tccgagacag    11700

aaaagtacaa agacatcgcg ggcttttaca gggaggtgga ggagcaaggg tataaagttt    11760

cttttgaatc cgcgagcaag aaggaagtcg acaagctcgt cgaggagggc aagctctaca    11820

tgttccaaat ttataacaag gacttttccg acaagagcca tgggacccca aacctccaca    11880

ccatgtactt caaactgctc tttgacgaga acaaccacgg gcaaatcagg ctgagcggcg    11940

gcgccgaatt attcatgcgc agggcctccc tcaagaagga agagctggtc gtccatccag    12000

ccaattcccc gatcgcgaac aagaacccgg acaatccgaa aaagaccacc accctgtcct    12060

acgacgtcta caaggacaaa cgcttcagcg aagaccagta cgaattacac atcccaattg    12120

cgattaataa gtgcccaaag aatatcttca aaattaatac agaggtcagg gtgctgctca    12180

aacacgacga caatccgtat gtcatcggca ttgacagggg cgagcgcaat ctgctctata    12240

tcgtggtcgt ggatgggaag ggcaatattg tggagcagta ctccctgaac gagattatca    12300

acaacttcaa tgggattagg attaagaccg actatcacag cctgctcgac aagaaagaaa    12360

aagagaggtt tgaggcccgc caaaactgga cctccattga gaatatcaaa gaattaaagg    12420

ccggctatat ttcccaagtc gtccacaaga tctgcgagct ggtggagaaa tatgacgccg    12480

tgattgcgct cgaagactta aattctgggt tcaagaactc ccgcgtgaag gtggaaaaac    12540

aggtgtatca gaaattcgag aaaatgctga tcgacaaact caattatatg gtggataaga    12600

agtccaaccc gtgtgccaca gggggcgcgc tgaagggcta tcagatcacc aacaagttcg    12660

agagcttcaa gagcatgagc acccagaacg ggtttatttt ctacatcccg gcgtggctca    12720

cctccaagat tgacccgagc accggcttcg tgaacctcct gaagacaaag tatacctcca    12780

ttgccgacag caagaagttt atctcctcct tcgaccgcat tatgtatgtg ccggaggagg    12840

acctcttcga gttcgccctc gactacaaaa acttcagccg cacagatgcg gattacatca    12900

agaagtggaa gctgtactcc tacgggaaca ggatccgcat cttcaggaat ccaaaaaaaa    12960

ataacgtctt tgactgggag gaagtgtgcc tgacatccgc ctacaaggaa ctgttcaata    13020

aatacggcat caattaccag cagggcgaca ttcgcgccct cctctgtgag cagtccgaca    13080

aagcgtttta ctccagcttc atggccctca tgtccctgat gctccaaatg aggaatagca    13140

tcacagggcg caccgacgtc gacttcctca tcagcccggt gaagaactcc gacgggatct    13200

tttacgactc ccgcaactat gaggcgcaag agaatgcgat cctcccgaag aacgccgatg    13260

cgaacggggc ctataatatc gccaggaaag tgctctgggc catcgggcag ttcaaaaagg    13320

cggaggatga gaagctcgac aaggtgaaaa ttgccatttc caacaaggag tggctggagt    13380

acgcgcagac ctccgtgaag cacggctcct ccgagacacc aggcacctcc gagagcgcga    13440

cgcccgaggg cggctccggc ggctccggca gcccgccgcc tgccctccct ccaaagaggc    13500

gaagaagtgg tggatcttcc ggggggtccc cccctcctgc tttacctcca aaaagacgtc    13560

gttctggtgg ttcaagtgga ggttctccac ctcctgcact tcctcccaag agaagaagga    13620

gcggcggcag ctcaggagga tcaccaccac cagctttgcc acccaaaagg cgccggtgaa    13680

agggctctct gtcatgattt catactttca ttattgagct ctgtaattac aattatgacc    13740

atgagaacat ctcttattgt gtggcctttt aattgctgat gttagtactg aaccaaagct    13800

tatcgtgatg atgtaaaagc aataagtact tgtttgtagc ttctttgtgt ctccctttgg    13860

gcttaataca tctgtttagt gttgtggctt tggcatagac ttctcttggt aataatgcct    13920

tgcaatgcaa aatttcaatt atcaaattct attatgttct caccttatgg taacagctta    13980

ccctgtggaa gatgagattc ttgagttgag tcattgccaa tttttggcat tagcttttga    14040

attagtgaat tttgacaaaa attaccgtga cactgatttt gttgaagctc ttaagtgtag    14100

tttttacaaa atttcagtgg ctcgttgtga ttatgtcaaa ctcacggcga atgtagttct    14160

tacagaattt cagtggctcc ctgcaggatc ccaatggcgc gcctagctaa ctagctagcc    14220

acgtgactcg cagaacgttg tgtggcgaga cggaaagaaa gtcacgcctc caaagagtgc    14280

agcatctctt ctggctctca cggtcctctg tggatccatc gatatcgaat tcctgcaggc    14340

tcgaggtcat tcatatgctt gagaagagag tcgggatagt ccaaaataaa acaaaggtaa    14400

gattacctgg tcaaaagtga aaacatcagt taaaaggtgg tataaagtaa aatatcggta    14460

ataaaaggtg gcccaaagtg aaatttactc ttttctacta ttataaaaat tgaggatgtt    14520

tttgtcggta ctttgatacg tcatttttgt atgaattggt ttttaagttt attcgctttt    14580

ggaaatgcat atctgtattt gagtcgggtt ttaagttcgt ttgcttttgt aaatacagag    14640

ggatttgtat aagaaatatc tttagaaaaa cccatatgct aatttgacat aatttttgag    14700

aaaaatatat attcaggcga attctcacaa tgaacaataa taagattaaa atagctttcc    14760

cccgttgcag cgcatgggta ttttttctag taaaaataaa agataaactt agactcaaaa    14820

catttacaaa aacaacccct aaagttccta aagcccaaag tgctatccac gatccatagc    14880

aagcccagcc caacccaacc caacccaacc caccccagtc cagccaactg gacaatagtc    14940

tccacacccc cccactatca ccgtgagttg tccgcacgca ccgcacgtct cgcagccaaa    15000

aaaaaaaaga aagaaaaaaa agaaaaagaa aaaacagcag gtgggtccgg gtcgtggggg    15060

ccggaaacgc gaggaggatc gcgagccagc gacgaggagc ttaggcctca tcgttgaaga    15120

tgcctctgcc gacagtggtc ccaaagatgg acccccaccc acgaggagca tcgtggaaaa    15180

agaagacgtt ccaaccacgt cttcaaagca agtggattga tgtgatatct ccactgacgt    15240

aagggatgac gcacaatccc actatccttc gaggcctcat cgttgaagat gcctctgccg    15300

acagtggtcc caaagatgga cccccaccca cgaggagcat cgtggaaaaa gaagacgttc    15360

caaccacgtc ttcaaagcaa gtggattgat gtgatatctc cactgacgta agggatgacg    15420

cacaatccca ctatccttcg aagctccctc cctccgcttc caaagaaacg ccccccatcg    15480

ccactatata catacccccc cctctcctcc catcccccca acccttctag aaccatcttc    15540

cacacactca agccacacta ttggagaaca cacagggaca acacaccata agatccaagg    15600

gaggcctccg ccgccgccgg taaccacccc gcccctctcc tctttctttc tccgtttttt    15660

tttccgtctc ggtctcgatc tttggccttg gtagtttggg tgggcgagag gcggcttcgt    15720

gcgcgcccag atcggtgcgc gggaggggcg ggatctcgcg gctggggctc tcgccggcgt    15780

ggatccggcc cggatctcgc ggggaatggg gctctcggat gtagatctgc gatccgccgt    15840

tgttggggga gatgatgggg ggtttaaaat ttccgccgtg ctaaacaaga tcaggaagag    15900

gggaaaaggg cactatggtt tatattttta tatatttctg ctgcttcgtc aggcttagat    15960

gtgctagatc tttctttctt ctttttgtgg gtagaatttg aatccctcag cattgttcat    16020

cggtagtttt tcttttcatg atttgtgaca aatgcagcct cgtgcggagc ttttttgtag    16080

gtagaaggcg gccgcatggc ccagtctaag cacgggttga cgaaggagat gactatgaag    16140

tatcgcatgg aaggctgcgt tgacggccac aaattcgtca ttaccggcga gggcatcggc    16200

taccccttta aggtaagttt ctgcttctac ctttgatata tatataataa ttatcattaa    16260

ttagtagtaa tataatattt caaatatttt tttcaaaata aaagaatgta gtatatagca    16320

attgcttttc tgtagtttat aagtgtgtat attttaattt ataacttttc taatatatga    16380

ccaaaatttg ttgatgtgca gggcaagcaa gcgataaacc tgtgcgtggt ggagggtggc    16440

cctctgccct tcgccgagga tatactctca gccgccttca tgtacgggaa tcgggtgttc    16500

acggagtacc cgcaagacat cgtggactac ttcaagaact cctgccccgc cggatacaca    16560

tgggaccgtt ccttcctctt cgaggacgga gccgtttgca tctgcaacgc ggacatcacc    16620

gtgtccgtcg aggagaactg catgtaccac gagtcaaagt tctatggagt gaacttcccg    16680

gccgatggtc ccgtgatgaa gaaaatgacg gacaactggg agccgtcgtg cgagaaaatc    16740

attcccgtcc caaaacaggg aatcctcaag ggcgacgtgt cgatgtacct acttctcaag    16800

gacggtggac ggctacggtg ccagttcgac actgtttaca aggcgaagtc ggtgccgagg    16860

aagatgccgg actggcactt tatccagcac aagctgacaa gggaggacag aagcgacgct    16920

aagaaccaga aatggcacct caccgagcac gccatcgcca gtggctctgc gctgcccggg    16980

tgaccctgca atgtgaccct agacttgtcc atcttctgga ttggccaact taattaatgt    17040

atgaaataaa aggatgcaca catagtgaca tgctaatcac tataatgtgg gcatcaaagt    17100

tgtgtgttat gtgtaattac taattatctg aataagagaa agagatcatc catatttctt    17160

atcctaaatg aatgtcacgt gtctttataa ttctttgatg aaccagatgc attttattaa    17220

ccaattccat atacatataa atattaatca tatataatta atatcaattg ggttagcaaa    17280

acaaatctag tctaggtgtg ttttgctaat tattggggga tagtgcaaaa agaaatctac    17340

gttctcaata attcagatag aaaacttaat aaagtgagat aatttacata gattgctttt    17400

atcctttgat atatgtgaaa ccatgcatga tataaggaaa atagatagag aaataatttt    17460

ttacatcgtt gaatatgtaa acaatttaat tcaagaagct aggaatataa atattgagga    17520

gtttatgatt attattatta ttttgatgtt caatgaagtt ttttttaatt tcatatgaag    17580

tatacaaaaa ttcttcatag atttttgttt ctatgccgta gttatcttta atatatttgt    17640

ggttgaagaa atttattgct agaaacgaat ggattgtcaa ttttttttta aagcaaatat    17700

atatgaaatt atactgtata ttattttagt catgattaaa atgtggcctt aattgaatca    17760

tctttctcat tcattttttc aaaagcatat caggatgatt gatatttatc tattttaaaa    17820

attaatttaa gggttcaaat taaatttaac ttaaaagtgt cctaaccgta gttaaaggtt    17880

tactttaaaa aaatactatg aaaaatctaa tcttctatga atcgagggcc cggccgtgac    17940

ggccacgagc gaactcctgc aggcgataaa aatgttttaa acgatatata ttataaaaaa    18000

aaacgtttca aaaataaata caaaaatgtt tttaaatata tataatttaa ctcattaaag    18060

aaaataaaaa tgcaagtgcg gtgacaagac aagctaaaag ttgcaaaaga aatggcaggg    18120

ctataaggct cacctactcc tggatttacc aaattttggt tcgtccctat actcgaaaaa    18180

taaaacaaaa taaatttcag tatcttcgtt tttgtatgct ttgactgtga ggcgaggcca    18240

actttcttct tctgtctgag atgaattttg tttgcctcct gtgaaggatg tatcattcaa    18300

agtgaatgtt ttgcaactgc cagtagtccc acatcgacca aatattctta ttacagtgtg    18360

tttatatagc acctggagaa ggaatgggtt gtttcaaaga ttaaataatt tctactaagt    18420

gtagattgcc gttaatttga gagtccaagt aatttctact aagtgtagat ttttttttgc    18480

ggccgcacaa caaacgcgcc ggcga                                          18505


<210>  133
<211>  19066
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3092 Full Plasmid Sequence

<400>  133
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cgggtccaga catcgttatg actcaatccc cctcaagcct ttcagcctcc gtgggcgaca     9780

gagttaccat tacctgccgc tcaagcactg gagcagtgac cacttctaac tacgctagct     9840

gggtgcagga gaagccagga aagctgttca aggggctgat tggaggcaca aacaatagag     9900

cccctggcgt gccatccagg ttttctggaa gcctgattgg cgataaggca acactgacca     9960

tctctagcct gcagcccgag gacttcgcta cctacttttg cgccctgtgg tatagcaatc    10020

actgggtgtt cggtcagggg actaaggtgg aactgaagag aggtggggga ggctccggtg    10080

ggggaggctc aggtggggga ggctcctcag gtgggggatc tgaggtgaag ctgctggaaa    10140

gcggcggtgg gctggtgcag cccggaggct ccctgaagct gtcatgtgcc gtgtctggat    10200

tttcactgac cgattacggc gtgaactggg tgagacaggc ccctggaagg ggactggagt    10260

ggattggagt gatttgggga gatgggatca cagactacaa ttccgcactg aaggatagat    10320

tcattatctc aaaggacaac ggaaagaaca ccgtgtatct gcagatgtct aaggtgagga    10380

gcgatgacac tgccctgtac tattgcgtga cagggctgtt tgactattgg gggcaaggca    10440

ctctggttac cgtgagcagc tatccatacg atgttcccga ctacgctggc tcctccgaga    10500

caccaggcac ctccgagagc gcgacgcccg agggcggctc cggcggctcc ggcagctcca    10560

agctggagaa gtttacaaac tgttacagcc tctccaaaac cctcaggttt aaagcgatcc    10620

cggtgggcaa gacccaggag aacatcgaca acaagaggct cctggtggaa gacgagaagc    10680

gcgccgaaga ctacaagggc gtgaagaagc tgctcgatag gtactacctc agctttatta    10740

acgacgtgct gcacagcatc aaactcaaga atctcaacaa ctacatctcc ctcttccgca    10800

aaaagacccg caccgagaag gagaacaagg agctggagaa cctggagatc aacctccgca    10860

aggaaatcgc caaagcgttc aagggcaatg aagggtacaa gagcctcttc aagaaagaca    10920

tcatcgaaac tatcctccca gagtttctcg atgacaagga cgagatcgcg ctggtgaact    10980

cctttaacgg gttcacaacc gcgtttaccg gcttctttga taacagggaa aatatgttct    11040

ccgaggaggc caagtccacc agcatcgcct tcaggtgtat caacgagaac ctcacccgct    11100

acatttccaa tatggacatt ttcgagaagg tggatgcgat cttcgataag cacgaggtgc    11160

aggagatcaa agagaagatt ctcaattccg attatgacgt cgaggatttc ttcgaagggg    11220

agttctttaa ttttgtgctc acacaagagg gcattgacgt gtacaacgcg attatcgggg    11280

gcttcgtcac agagtccggg gagaagatta aggggctgaa tgagtacatc aatctgtaca    11340

atcagaagac caagcagaaa ctgccgaaat tcaagccgct ctacaagcaa gtcctgtccg    11400

atagggaaag cctctccttc tacggcgagg gctataccag cgacgaggag gtgctggaag    11460

tcttccgcaa cacactgaat aagaatagcg agattttctc ctccatcaag aagctcgaga    11520

agctctttaa gaactttgac gagtacagct ccgccgggat tttcgtgaag aacgggccgg    11580

cgatcagcac catctccaag gacatctttg gcgagtggaa cgtcatcagg gacaagtgga    11640

acgccgagta cgacgacatc cacctgaaga agaaggcggt ggtgaccgag aagtatgagg    11700

acgatcgcag gaagtccttc aaaaaaatcg gctccttcag cctcgaacag ctccaggagt    11760

atgccgatgc ggatctgtcc gtcgtcgaga agctgaagga aatcatcatt cagaaggtcg    11820

acgagatcta taaagtgtac gggtccagcg agaagctgtt cgacgccgac tttgtgctcg    11880

agaagtccct caaaaagaat gacgccgtgg tggccattat gaaagacctg ctcgactccg    11940

tgaagtcctt cgaaaattac attaaagcgt tctttgggga ggggaaggaa actaacaggg    12000

atgagtcctt ctatggcgac tttgtcctcg cgtacgacat cctgctgaag gtcgaccaca    12060

tttacgacgc gatccgcaac tacgtgacac agaagccgta ctccaaagac aagttcaagc    12120

tgtacttcca gaacccgcaa tttatggggg gctgggacaa ggataaagag acagactacc    12180

gcgcgacaat tctccgctat ggctccaaat actatctggc catcatggac aagaagtacg    12240

cgaagtgcct gcagaagatc gacaaagacg acgtcaatgg caactatgaa aagatcaact    12300

acaagctgct gccgggtccg aacaagatgc tcccgaaggt gttcttcagc aagaagtgga    12360

tggcctacta caatccaagc gaggatattc agaaaatcta taaaaacggg accttcaaga    12420

agggggacat gtttaacctc aacgactgcc acaagctcat tgatttcttc aaggatagca    12480

tttcccgcta cccgaaatgg tccaatgcgt acgattttaa cttctccgag acagaaaagt    12540

acaaagacat cgcgggcttt tacagggagg tggaggagca agggtataaa gtttcttttg    12600

aatccgcgag caagaaggaa gtcgacaagc tcgtcgagga gggcaagctc tacatgttcc    12660

aaatttataa caaggacttt tccgacaaga gccatgggac cccaaacctc cacaccatgt    12720

acttcaaact gctctttgac gagaacaacc acgggcaaat caggctgagc ggcggcgccg    12780

aattattcat gcgcagggcc tccctcaaga aggaagagct ggtcgtccat ccagccaatt    12840

ccccgatcgc gaacaagaac ccggacaatc cgaaaaagac caccaccctg tcctacgacg    12900

tctacaagga caaacgcttc agcgaagacc agtacgaatt acacatccca attgcgatta    12960

ataagtgccc aaagaatatc ttcaaaatta atacagaggt cagggtgctg ctcaaacacg    13020

acgacaatcc gtatgtcatc ggcattgaca ggggcgagcg caatctgctc tatatcgtgg    13080

tcgtggatgg gaagggcaat attgtggagc agtactccct gaacgagatt atcaacaact    13140

tcaatgggat taggattaag accgactatc acagcctgct cgacaagaaa gaaaaagaga    13200

ggtttgaggc ccgccaaaac tggacctcca ttgagaatat caaagaatta aaggccggct    13260

atatttccca agtcgtccac aagatctgcg agctggtgga gaaatatgac gccgtgattg    13320

cgctcgaaga cttaaattct gggttcaaga actcccgcgt gaaggtggaa aaacaggtgt    13380

atcagaaatt cgagaaaatg ctgatcgaca aactcaatta tatggtggat aagaagtcca    13440

acccgtgtgc cacagggggc gcgctgaagg gctatcagat caccaacaag ttcgagagct    13500

tcaagagcat gagcacccag aacgggttta ttttctacat cccggcgtgg ctcacctcca    13560

agattgaccc gagcaccggc ttcgtgaacc tcctgaagac aaagtatacc tccattgccg    13620

acagcaagaa gtttatctcc tccttcgacc gcattatgta tgtgccggag gaggacctct    13680

tcgagttcgc cctcgactac aaaaacttca gccgcacaga tgcggattac atcaagaagt    13740

ggaagctgta ctcctacggg aacaggatcc gcatcttcag gaatccaaaa aaaaataacg    13800

tctttgactg ggaggaagtg tgcctgacat ccgcctacaa ggaactgttc aataaatacg    13860

gcatcaatta ccagcagggc gacattcgcg ccctcctctg tgagcagtcc gacaaagcgt    13920

tttactccag cttcatggcc ctcatgtccc tgatgctcca aatgaggaat agcatcacag    13980

ggcgcaccga cgtcgacttc ctcatcagcc cggtgaagaa ctccgacggg atcttttacg    14040

actcccgcaa ctatgaggcg caagagaatg cgatcctccc gaagaacgcc gatgcgaacg    14100

gggcctataa tatcgccagg aaagtgctct gggccatcgg gcagttcaaa aaggcggagg    14160

atgagaagct cgacaaggtg aaaattgcca tttccaacaa ggagtggctg gagtacgcgc    14220

agacctccgt gaagcactga aagggctctc tgtcatgatt tcatactttc attattgagc    14280

tctgtaatta caattatgac catgagaaca tctcttattg tgtggccttt taattgctga    14340

tgttagtact gaaccaaagc ttatcgtgat gatgtaaaag caataagtac ttgtttgtag    14400

cttctttgtg tctccctttg ggcttaatac atctgtttag tgttgtggct ttggcataga    14460

cttctcttgg taataatgcc ttgcaatgca aaatttcaat tatcaaattc tattatgttc    14520

tcaccttatg gtaacagctt accctgtgga agatgagatt cttgagttga gtcattgcca    14580

atttttggca ttagcttttg aattagtgaa ttttgacaaa aattaccgtg acactgattt    14640

tgttgaagct cttaagtgta gtttttacaa aatttcagtg gctcgttgtg attatgtcaa    14700

actcacggcg aatgtagttc ttacagaatt tcagtggctc cctgcaggat cccaatggcg    14760

cgcctagcta actagctagc cacgtgactc gcagaacgtt gtgtggcgag acggaaagaa    14820

agtcacgcct ccaaagagtg cagcatctct tctggctctc acggtcctct gtggatccat    14880

cgatatcgaa ttcctgcagg ctcgaggtca ttcatatgct tgagaagaga gtcgggatag    14940

tccaaaataa aacaaaggta agattacctg gtcaaaagtg aaaacatcag ttaaaaggtg    15000

gtataaagta aaatatcggt aataaaaggt ggcccaaagt gaaatttact cttttctact    15060

attataaaaa ttgaggatgt ttttgtcggt actttgatac gtcatttttg tatgaattgg    15120

tttttaagtt tattcgcttt tggaaatgca tatctgtatt tgagtcgggt tttaagttcg    15180

tttgcttttg taaatacaga gggatttgta taagaaatat ctttagaaaa acccatatgc    15240

taatttgaca taatttttga gaaaaatata tattcaggcg aattctcaca atgaacaata    15300

ataagattaa aatagctttc ccccgttgca gcgcatgggt attttttcta gtaaaaataa    15360

aagataaact tagactcaaa acatttacaa aaacaacccc taaagttcct aaagcccaaa    15420

gtgctatcca cgatccatag caagcccagc ccaacccaac ccaacccaac ccaccccagt    15480

ccagccaact ggacaatagt ctccacaccc ccccactatc accgtgagtt gtccgcacgc    15540

accgcacgtc tcgcagccaa aaaaaaaaag aaagaaaaaa aagaaaaaga aaaaacagca    15600

ggtgggtccg ggtcgtgggg gccggaaacg cgaggaggat cgcgagccag cgacgaggag    15660

cttaggcctc atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc    15720

cacgaggagc atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg    15780

atgtgatatc tccactgacg taagggatga cgcacaatcc cactatcctt cgaggcctca    15840

tcgttgaaga tgcctctgcc gacagtggtc ccaaagatgg acccccaccc acgaggagca    15900

tcgtggaaaa agaagacgtt ccaaccacgt cttcaaagca agtggattga tgtgatatct    15960

ccactgacgt aagggatgac gcacaatccc actatccttc gaagctccct ccctccgctt    16020

ccaaagaaac gccccccatc gccactatat acataccccc ccctctcctc ccatcccccc    16080

aacccttcta gaaccatctt ccacacactc aagccacact attggagaac acacagggac    16140

aacacaccat aagatccaag ggaggcctcc gccgccgccg gtaaccaccc cgcccctctc    16200

ctctttcttt ctccgttttt ttttccgtct cggtctcgat ctttggcctt ggtagtttgg    16260

gtgggcgaga ggcggcttcg tgcgcgccca gatcggtgcg cgggaggggc gggatctcgc    16320

ggctggggct ctcgccggcg tggatccggc ccggatctcg cggggaatgg ggctctcgga    16380

tgtagatctg cgatccgccg ttgttggggg agatgatggg gggtttaaaa tttccgccgt    16440

gctaaacaag atcaggaaga ggggaaaagg gcactatggt ttatattttt atatatttct    16500

gctgcttcgt caggcttaga tgtgctagat ctttctttct tctttttgtg ggtagaattt    16560

gaatccctca gcattgttca tcggtagttt ttcttttcat gatttgtgac aaatgcagcc    16620

tcgtgcggag cttttttgta ggtagaaggc ggccgcatgg cccagtctaa gcacgggttg    16680

acgaaggaga tgactatgaa gtatcgcatg gaaggctgcg ttgacggcca caaattcgtc    16740

attaccggcg agggcatcgg ctaccccttt aaggtaagtt tctgcttcta cctttgatat    16800

atatataata attatcatta attagtagta atataatatt tcaaatattt ttttcaaaat    16860

aaaagaatgt agtatatagc aattgctttt ctgtagttta taagtgtgta tattttaatt    16920

tataactttt ctaatatatg accaaaattt gttgatgtgc agggcaagca agcgataaac    16980

ctgtgcgtgg tggagggtgg ccctctgccc ttcgccgagg atatactctc agccgccttc    17040

atgtacggga atcgggtgtt cacggagtac ccgcaagaca tcgtggacta cttcaagaac    17100

tcctgccccg ccggatacac atgggaccgt tccttcctct tcgaggacgg agccgtttgc    17160

atctgcaacg cggacatcac cgtgtccgtc gaggagaact gcatgtacca cgagtcaaag    17220

ttctatggag tgaacttccc ggccgatggt cccgtgatga agaaaatgac ggacaactgg    17280

gagccgtcgt gcgagaaaat cattcccgtc ccaaaacagg gaatcctcaa gggcgacgtg    17340

tcgatgtacc tacttctcaa ggacggtgga cggctacggt gccagttcga cactgtttac    17400

aaggcgaagt cggtgccgag gaagatgccg gactggcact ttatccagca caagctgaca    17460

agggaggaca gaagcgacgc taagaaccag aaatggcacc tcaccgagca cgccatcgcc    17520

agtggctctg cgctgcccgg gtgaccctgc aatgtgaccc tagacttgtc catcttctgg    17580

attggccaac ttaattaatg tatgaaataa aaggatgcac acatagtgac atgctaatca    17640

ctataatgtg ggcatcaaag ttgtgtgtta tgtgtaatta ctaattatct gaataagaga    17700

aagagatcat ccatatttct tatcctaaat gaatgtcacg tgtctttata attctttgat    17760

gaaccagatg cattttatta accaattcca tatacatata aatattaatc atatataatt    17820

aatatcaatt gggttagcaa aacaaatcta gtctaggtgt gttttgctaa ttattggggg    17880

atagtgcaaa aagaaatcta cgttctcaat aattcagata gaaaacttaa taaagtgaga    17940

taatttacat agattgcttt tatcctttga tatatgtgaa accatgcatg atataaggaa    18000

aatagataga gaaataattt tttacatcgt tgaatatgta aacaatttaa ttcaagaagc    18060

taggaatata aatattgagg agtttatgat tattattatt attttgatgt tcaatgaagt    18120

tttttttaat ttcatatgaa gtatacaaaa attcttcata gatttttgtt tctatgccgt    18180

agttatcttt aatatatttg tggttgaaga aatttattgc tagaaacgaa tggattgtca    18240

attttttttt aaagcaaata tatatgaaat tatactgtat attattttag tcatgattaa    18300

aatgtggcct taattgaatc atctttctca ttcatttttt caaaagcata tcaggatgat    18360

tgatatttat ctattttaaa aattaattta agggttcaaa ttaaatttaa cttaaaagtg    18420

tcctaaccgt agttaaaggt ttactttaaa aaaatactat gaaaaatcta atcttctatg    18480

aatcgagggc ccggccgtga cggccacgag cgaactcctg caggcgataa aaatgtttta    18540

aacgatatat attataaaaa aaaacgtttc aaaaataaat acaaaaatgt ttttaaatat    18600

atataattta actcattaaa gaaaataaaa atgcaagtgc ggtgacaaga caagctaaaa    18660

gttgcaaaag aaatggcagg gctataaggc tcacctactc ctggatttac caaattttgg    18720

ttcgtcccta tactcgaaaa ataaaacaaa ataaatttca gtatcttcgt ttttgtatgc    18780

tttgactgtg aggcgaggcc aactttcttc ttctgtctga gatgaatttt gtttgcctcc    18840

tgtgaaggat gtatcattca aagtgaatgt tttgcaactg ccagtagtcc cacatcgacc    18900

aaatattctt attacagtgt gtttatatag cacctggaga aggaatgggt tgtttcaaag    18960

attaaataat ttctactaag tgtagattgc cgttaatttg agagtccaag taatttctac    19020

taagtgtaga tttttttttg cggccgcaca acaaacgcgc cggcga                   19066


<210>  134
<211>  18424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3089 Full Plasmid Sequence

<400>  134
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cgaactctac tatcaaaatt gcaacaagga aataccttgg gaagcaaaat gtttatgata     9780

ttggtgtgga aagagaccat aattttgctt tgaagaatgg atttatagcc tcaaattgtt     9840

tcaacggctc ctccgagaca ccaggcacct ccgagagcgc gacgcccgag ggcggctccg     9900

gcggctccgg cagctccaag ctggagaagt ttacaaactg ttacagcctc tccaaaaccc     9960

tcaggtttaa agcgatcccg gtgggcaaga cccaggagaa catcgacaac aagaggctcc    10020

tggtggaaga cgagaagcgc gccgaagact acaagggcgt gaagaagctg ctcgataggt    10080

actacctcag ctttattaac gacgtgctgc acagcatcaa actcaagaat ctcaacaact    10140

acatctccct cttccgcaaa aagacccgca ccgagaagga gaacaaggag ctggagaacc    10200

tggagatcaa cctccgcaag gaaatcgcca aagcgttcaa gggcaatgaa gggtacaaga    10260

gcctcttcaa gaaagacatc atcgaaacta tcctcccaga gtttctcgat gacaaggacg    10320

agatcgcgct ggtgaactcc tttaacgggt tcacaaccgc gtttaccggc ttctttgata    10380

acagggaaaa tatgttctcc gaggaggcca agtccaccag catcgccttc aggtgtatca    10440

acgagaacct cacccgctac atttccaata tggacatttt cgagaaggtg gatgcgatct    10500

tcgataagca cgaggtgcag gagatcaaag agaagattct caattccgat tatgacgtcg    10560

aggatttctt cgaaggggag ttctttaatt ttgtgctcac acaagagggc attgacgtgt    10620

acaacgcgat tatcgggggc ttcgtcacag agtccgggga gaagattaag gggctgaatg    10680

agtacatcaa tctgtacaat cagaagacca agcagaaact gccgaaattc aagccgctct    10740

acaagcaagt cctgtccgat agggaaagcc tctccttcta cggcgagggc tataccagcg    10800

acgaggaggt gctggaagtc ttccgcaaca cactgaataa gaatagcgag attttctcct    10860

ccatcaagaa gctcgagaag ctctttaaga actttgacga gtacagctcc gccgggattt    10920

tcgtgaagaa cgggccggcg atcagcacca tctccaagga catctttggc gagtggaacg    10980

tcatcaggga caagtggaac gccgagtacg acgacatcca cctgaagaag aaggcggtgg    11040

tgaccgagaa gtatgaggac gatcgcagga agtccttcaa aaaaatcggc tccttcagcc    11100

tcgaacagct ccaggagtat gccgatgcgg atctgtccgt cgtcgagaag ctgaaggaaa    11160

tcatcattca gaaggtcgac gagatctata aagtgtacgg gtccagcgag aagctgttcg    11220

acgccgactt tgtgctcgag aagtccctca aaaagaatga cgccgtggtg gccattatga    11280

aagacctgct cgactccgtg aagtccttcg aaaattacat taaagcgttc tttggggagg    11340

ggaaggaaac taacagggat gagtccttct atggcgactt tgtcctcgcg tacgacatcc    11400

tgctgaaggt cgaccacatt tacgacgcga tccgcaacta cgtgacacag aagccgtact    11460

ccaaagacaa gttcaagctg tacttccaga acccgcaatt tatggggggc tgggacaagg    11520

ataaagagac agactaccgc gcgacaattc tccgctatgg ctccaaatac tatctggcca    11580

tcatggacaa gaagtacgcg aagtgcctgc agaagatcga caaagacgac gtcaatggca    11640

actatgaaaa gatcaactac aagctgctgc cgggtccgaa caagatgctc ccgaaggtgt    11700

tcttcagcaa gaagtggatg gcctactaca atccaagcga ggatattcag aaaatctata    11760

aaaacgggac cttcaagaag ggggacatgt ttaacctcaa cgactgccac aagctcattg    11820

atttcttcaa ggatagcatt tcccgctacc cgaaatggtc caatgcgtac gattttaact    11880

tctccgagac agaaaagtac aaagacatcg cgggctttta cagggaggtg gaggagcaag    11940

ggtataaagt ttcttttgaa tccgcgagca agaaggaagt cgacaagctc gtcgaggagg    12000

gcaagctcta catgttccaa atttataaca aggacttttc cgacaagagc catgggaccc    12060

caaacctcca caccatgtac ttcaaactgc tctttgacga gaacaaccac gggcaaatca    12120

ggctgagcgg cggcgccgaa ttattcatgc gcagggcctc cctcaagaag gaagagctgg    12180

tcgtccatcc agccaattcc ccgatcgcga acaagaaccc ggacaatccg aaaaagacca    12240

ccaccctgtc ctacgacgtc tacaaggaca aacgcttcag cgaagaccag tacgaattac    12300

acatcccaat tgcgattaat aagtgcccaa agaatatctt caaaattaat acagaggtca    12360

gggtgctgct caaacacgac gacaatccgt atgtcatcgg cattgacagg ggcgagcgca    12420

atctgctcta tatcgtggtc gtggatggga agggcaatat tgtggagcag tactccctga    12480

acgagattat caacaacttc aatgggatta ggattaagac cgactatcac agcctgctcg    12540

acaagaaaga aaaagagagg tttgaggccc gccaaaactg gacctccatt gagaatatca    12600

aagaattaaa ggccggctat atttcccaag tcgtccacaa gatctgcgag ctggtggaga    12660

aatatgacgc cgtgattgcg ctcgaagact taaattctgg gttcaagaac tcccgcgtga    12720

aggtggaaaa acaggtgtat cagaaattcg agaaaatgct gatcgacaaa ctcaattata    12780

tggtggataa gaagtccaac ccgtgtgcca cagggggcgc gctgaagggc tatcagatca    12840

ccaacaagtt cgagagcttc aagagcatga gcacccagaa cgggtttatt ttctacatcc    12900

cggcgtggct cacctccaag attgacccga gcaccggctt cgtgaacctc ctgaagacaa    12960

agtatacctc cattgccgac agcaagaagt ttatctcctc cttcgaccgc attatgtatg    13020

tgccggagga ggacctcttc gagttcgccc tcgactacaa aaacttcagc cgcacagatg    13080

cggattacat caagaagtgg aagctgtact cctacgggaa caggatccgc atcttcagga    13140

atccaaaaaa aaataacgtc tttgactggg aggaagtgtg cctgacatcc gcctacaagg    13200

aactgttcaa taaatacggc atcaattacc agcagggcga cattcgcgcc ctcctctgtg    13260

agcagtccga caaagcgttt tactccagct tcatggccct catgtccctg atgctccaaa    13320

tgaggaatag catcacaggg cgcaccgacg tcgacttcct catcagcccg gtgaagaact    13380

ccgacgggat cttttacgac tcccgcaact atgaggcgca agagaatgcg atcctcccga    13440

agaacgccga tgcgaacggg gcctataata tcgccaggaa agtgctctgg gccatcgggc    13500

agttcaaaaa ggcggaggat gagaagctcg acaaggtgaa aattgccatt tccaacaagg    13560

agtggctgga gtacgcgcag acctccgtga agcactgaaa gggctctctg tcatgatttc    13620

atactttcat tattgagctc tgtaattaca attatgacca tgagaacatc tcttattgtg    13680

tggcctttta attgctgatg ttagtactga accaaagctt atcgtgatga tgtaaaagca    13740

ataagtactt gtttgtagct tctttgtgtc tccctttggg cttaatacat ctgtttagtg    13800

ttgtggcttt ggcatagact tctcttggta ataatgcctt gcaatgcaaa atttcaatta    13860

tcaaattcta ttatgttctc accttatggt aacagcttac cctgtggaag atgagattct    13920

tgagttgagt cattgccaat ttttggcatt agcttttgaa ttagtgaatt ttgacaaaaa    13980

ttaccgtgac actgattttg ttgaagctct taagtgtagt ttttacaaaa tttcagtggc    14040

tcgttgtgat tatgtcaaac tcacggcgaa tgtagttctt acagaatttc agtggctccc    14100

tgcaggatcc caatggcgcg cctagctaac tagctagcca cgtgactcgc agaacgttgt    14160

gtggcgagac ggaaagaaag tcacgcctcc aaagagtgca gcatctcttc tggctctcac    14220

ggtcctctgt ggatccatcg atatcgaatt cctgcaggct cgaggtcatt catatgcttg    14280

agaagagagt cgggatagtc caaaataaaa caaaggtaag attacctggt caaaagtgaa    14340

aacatcagtt aaaaggtggt ataaagtaaa atatcggtaa taaaaggtgg cccaaagtga    14400

aatttactct tttctactat tataaaaatt gaggatgttt ttgtcggtac tttgatacgt    14460

catttttgta tgaattggtt tttaagttta ttcgcttttg gaaatgcata tctgtatttg    14520

agtcgggttt taagttcgtt tgcttttgta aatacagagg gatttgtata agaaatatct    14580

ttagaaaaac ccatatgcta atttgacata atttttgaga aaaatatata ttcaggcgaa    14640

ttctcacaat gaacaataat aagattaaaa tagctttccc ccgttgcagc gcatgggtat    14700

tttttctagt aaaaataaaa gataaactta gactcaaaac atttacaaaa acaaccccta    14760

aagttcctaa agcccaaagt gctatccacg atccatagca agcccagccc aacccaaccc    14820

aacccaaccc accccagtcc agccaactgg acaatagtct ccacaccccc ccactatcac    14880

cgtgagttgt ccgcacgcac cgcacgtctc gcagccaaaa aaaaaaagaa agaaaaaaaa    14940

gaaaaagaaa aaacagcagg tgggtccggg tcgtgggggc cggaaacgcg aggaggatcg    15000

cgagccagcg acgaggagct taggcctcat cgttgaagat gcctctgccg acagtggtcc    15060

caaagatgga cccccaccca cgaggagcat cgtggaaaaa gaagacgttc caaccacgtc    15120

ttcaaagcaa gtggattgat gtgatatctc cactgacgta agggatgacg cacaatccca    15180

ctatccttcg aggcctcatc gttgaagatg cctctgccga cagtggtccc aaagatggac    15240

ccccacccac gaggagcatc gtggaaaaag aagacgttcc aaccacgtct tcaaagcaag    15300

tggattgatg tgatatctcc actgacgtaa gggatgacgc acaatcccac tatccttcga    15360

agctccctcc ctccgcttcc aaagaaacgc cccccatcgc cactatatac ataccccccc    15420

ctctcctccc atccccccaa cccttctaga accatcttcc acacactcaa gccacactat    15480

tggagaacac acagggacaa cacaccataa gatccaaggg aggcctccgc cgccgccggt    15540

aaccaccccg cccctctcct ctttctttct ccgttttttt ttccgtctcg gtctcgatct    15600

ttggccttgg tagtttgggt gggcgagagg cggcttcgtg cgcgcccaga tcggtgcgcg    15660

ggaggggcgg gatctcgcgg ctggggctct cgccggcgtg gatccggccc ggatctcgcg    15720

gggaatgggg ctctcggatg tagatctgcg atccgccgtt gttgggggag atgatggggg    15780

gtttaaaatt tccgccgtgc taaacaagat caggaagagg ggaaaagggc actatggttt    15840

atatttttat atatttctgc tgcttcgtca ggcttagatg tgctagatct ttctttcttc    15900

tttttgtggg tagaatttga atccctcagc attgttcatc ggtagttttt cttttcatga    15960

tttgtgacaa atgcagcctc gtgcggagct tttttgtagg tagaaggcgg ccgcatggcc    16020

cagtctaagc acgggttgac gaaggagatg actatgaagt atcgcatgga aggctgcgtt    16080

gacggccaca aattcgtcat taccggcgag ggcatcggct acccctttaa ggtaagtttc    16140

tgcttctacc tttgatatat atataataat tatcattaat tagtagtaat ataatatttc    16200

aaatattttt ttcaaaataa aagaatgtag tatatagcaa ttgcttttct gtagtttata    16260

agtgtgtata ttttaattta taacttttct aatatatgac caaaatttgt tgatgtgcag    16320

ggcaagcaag cgataaacct gtgcgtggtg gagggtggcc ctctgccctt cgccgaggat    16380

atactctcag ccgccttcat gtacgggaat cgggtgttca cggagtaccc gcaagacatc    16440

gtggactact tcaagaactc ctgccccgcc ggatacacat gggaccgttc cttcctcttc    16500

gaggacggag ccgtttgcat ctgcaacgcg gacatcaccg tgtccgtcga ggagaactgc    16560

atgtaccacg agtcaaagtt ctatggagtg aacttcccgg ccgatggtcc cgtgatgaag    16620

aaaatgacgg acaactggga gccgtcgtgc gagaaaatca ttcccgtccc aaaacaggga    16680

atcctcaagg gcgacgtgtc gatgtaccta cttctcaagg acggtggacg gctacggtgc    16740

cagttcgaca ctgtttacaa ggcgaagtcg gtgccgagga agatgccgga ctggcacttt    16800

atccagcaca agctgacaag ggaggacaga agcgacgcta agaaccagaa atggcacctc    16860

accgagcacg ccatcgccag tggctctgcg ctgcccgggt gaccctgcaa tgtgacccta    16920

gacttgtcca tcttctggat tggccaactt aattaatgta tgaaataaaa ggatgcacac    16980

atagtgacat gctaatcact ataatgtggg catcaaagtt gtgtgttatg tgtaattact    17040

aattatctga ataagagaaa gagatcatcc atatttctta tcctaaatga atgtcacgtg    17100

tctttataat tctttgatga accagatgca ttttattaac caattccata tacatataaa    17160

tattaatcat atataattaa tatcaattgg gttagcaaaa caaatctagt ctaggtgtgt    17220

tttgctaatt attgggggat agtgcaaaaa gaaatctacg ttctcaataa ttcagataga    17280

aaacttaata aagtgagata atttacatag attgctttta tcctttgata tatgtgaaac    17340

catgcatgat ataaggaaaa tagatagaga aataattttt tacatcgttg aatatgtaaa    17400

caatttaatt caagaagcta ggaatataaa tattgaggag tttatgatta ttattattat    17460

tttgatgttc aatgaagttt tttttaattt catatgaagt atacaaaaat tcttcataga    17520

tttttgtttc tatgccgtag ttatctttaa tatatttgtg gttgaagaaa tttattgcta    17580

gaaacgaatg gattgtcaat ttttttttaa agcaaatata tatgaaatta tactgtatat    17640

tattttagtc atgattaaaa tgtggcctta attgaatcat ctttctcatt cattttttca    17700

aaagcatatc aggatgattg atatttatct attttaaaaa ttaatttaag ggttcaaatt    17760

aaatttaact taaaagtgtc ctaaccgtag ttaaaggttt actttaaaaa aatactatga    17820

aaaatctaat cttctatgaa tcgagggccc ggccgtgacg gccacgagcg aactcctgca    17880

ggcgataaaa atgttttaaa cgatatatat tataaaaaaa aacgtttcaa aaataaatac    17940

aaaaatgttt ttaaatatat ataatttaac tcattaaaga aaataaaaat gcaagtgcgg    18000

tgacaagaca agctaaaagt tgcaaaagaa atggcagggc tataaggctc acctactcct    18060

ggatttacca aattttggtt cgtccctata ctcgaaaaat aaaacaaaat aaatttcagt    18120

atcttcgttt ttgtatgctt tgactgtgag gcgaggccaa ctttcttctt ctgtctgaga    18180

tgaattttgt ttgcctcctg tgaaggatgt atcattcaaa gtgaatgttt tgcaactgcc    18240

agtagtccca catcgaccaa atattcttat tacagtgtgt ttatatagca cctggagaag    18300

gaatgggttg tttcaaagat taaataattt ctactaagtg tagattgccg ttaatttgag    18360

agtccaagta atttctacta agtgtagatt tttttttgcg gccgcacaac aaacgcgccg    18420

gcga                                                                 18424


<210>  135
<211>  18232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3088 Full Plasmid Sequence

<400>  135
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccattgggat cctgcaggga gccactgaaa ttctgtaaga     8160

actacattcg ccgtgagttt gacataatca caacgagcca ctgaaatttt gtaaaaacta     8220

cacttaagag cttcaacaaa atcagtgtca cggtaatttt tgtcaaaatt cactaattca     8280

aaagctaatg ccaaaaattg gcaatgactc aactcaagaa tctcatcttc cacagggtaa     8340

gctgttacca taaggtgaga acataataga atttgataat tgaaattttg cattgcaagg     8400

cattattacc aagagaagtc tatgccaaag ccacaacact aaacagatgt attaagccca     8460

aagggagaca caaagaagct acaaacaagt acttattgct tttacatcat cacgataagc     8520

tttggttcag tactaacatc agcaattaaa aggccacaca ataagagatg ttctcatggt     8580

cataattgta attacagagc tcaataatga aagtatgaaa tcatgacaga gagccctttc     8640

agtgcttcac ggaggtctgc gcgtactcca gccactcctt gttggaaatg gcaattttca     8700

ccttgtcgag cttctcatcc tccgcctttt tgaactgccc gatggcccag agcactttcc     8760

tggcgatatt ataggccccg ttcgcatcgg cgttcttcgg gaggatcgca ttctcttgcg     8820

cctcatagtt gcgggagtcg taaaagatcc cgtcggagtt cttcaccggg ctgatgagga     8880

agtcgacgtc ggtgcgccct gtgatgctat tcctcatttg gagcatcagg gacatgaggg     8940

ccatgaagct ggagtaaaac gctttgtcgg actgctcaca gaggagggcg cgaatgtcgc     9000

cctgctggta attgatgccg tatttattga acagttcctt gtaggcggat gtcaggcaca     9060

cttcctccca gtcaaagacg ttattttttt ttggattcct gaagatgcgg atcctgttcc     9120

cgtaggagta cagcttccac ttcttgatgt aatccgcatc tgtgcggctg aagtttttgt     9180

agtcgagggc gaactcgaag aggtcctcct ccggcacata cataatgcgg tcgaaggagg     9240

agataaactt cttgctgtcg gcaatggagg tatactttgt cttcaggagg ttcacgaagc     9300

cggtgctcgg gtcaatcttg gaggtgagcc acgccgggat gtagaaaata aacccgttct     9360

gggtgctcat gctcttgaag ctctcgaact tgttggtgat ctgatagccc ttcagcgcgc     9420

cccctgtggc acacgggttg gacttcttat ccaccatata attgagtttg tcgatcagca     9480

ttttctcgaa tttctgatac acctgttttt ccaccttcac gcgggagttc ttgaacccag     9540

aatttaagtc ttcgagcgca atcacggcgt catatttctc caccagctcg cagatcttgt     9600

ggacgacttg ggaaatatag ccggccttta attctttgat attctcaatg gaggtccagt     9660

tttggcgggc ctcaaacctc tctttttctt tcttgtcgag caggctgtga tagtcggtct     9720

taatcctaat cccattgaag ttgttgataa tctcgttcag ggagtactgc tccacaatat     9780

tgcccttccc atccacgacc acgatataga gcagattgcg ctcgcccctg tcaatgccga     9840

tgacatacgg attgtcgtcg tgtttgagca gcaccctgac ctctgtatta attttgaaga     9900

tattctttgg gcacttatta atcgcaattg ggatgtgtaa ttcgtactgg tcttcgctga     9960

agcgtttgtc cttgtagacg tcgtaggaca gggtggtggt ctttttcgga ttgtccgggt    10020

tcttgttcgc gatcggggaa ttggctggat ggacgaccag ctcttccttc ttgagggagg    10080

ccctgcgcat gaataattcg gcgccgccgc tcagcctgat ttgcccgtgg ttgttctcgt    10140

caaagagcag tttgaagtac atggtgtgga ggtttggggt cccatggctc ttgtcggaaa    10200

agtccttgtt ataaatttgg aacatgtaga gcttgccctc ctcgacgagc ttgtcgactt    10260

ccttcttgct cgcggattca aaagaaactt tatacccttg ctcctccacc tccctgtaaa    10320

agcccgcgat gtctttgtac ttttctgtct cggagaagtt aaaatcgtac gcattggacc    10380

atttcgggta gcgggaaatg ctatccttga agaaatcaat gagcttgtgg cagtcgttga    10440

ggttaaacat gtcccccttc ttgaaggtcc cgtttttata gattttctga atatcctcgc    10500

ttggattgta gtaggccatc cacttcttgc tgaagaacac cttcgggagc atcttgttcg    10560

gacccggcag cagcttgtag ttgatctttt catagttgcc attgacgtcg tctttgtcga    10620

tcttctgcag gcacttcgcg tacttcttgt ccatgatggc cagatagtat ttggagccat    10680

agcggagaat tgtcgcgcgg tagtctgtct ctttatcctt gtcccagccc cccataaatt    10740

gcgggttctg gaagtacagc ttgaacttgt ctttggagta cggcttctgt gtcacgtagt    10800

tgcggatcgc gtcgtaaatg tggtcgacct tcagcaggat gtcgtacgcg aggacaaagt    10860

cgccatagaa ggactcatcc ctgttagttt ccttcccctc cccaaagaac gctttaatgt    10920

aattttcgaa ggacttcacg gagtcgagca ggtctttcat aatggccacc acggcgtcat    10980

tctttttgag ggacttctcg agcacaaagt cggcgtcgaa cagcttctcg ctggacccgt    11040

acactttata gatctcgtcg accttctgaa tgatgatttc cttcagcttc tcgacgacgg    11100

acagatccgc atcggcatac tcctggagct gttcgaggct gaaggagccg atttttttga    11160

aggacttcct gcgatcgtcc tcatacttct cggtcaccac cgccttcttc ttcaggtgga    11220

tgtcgtcgta ctcggcgttc cacttgtccc tgatgacgtt ccactcgcca aagatgtcct    11280

tggagatggt gctgatcgcc ggcccgttct tcacgaaaat cccggcggag ctgtactcgt    11340

caaagttctt aaagagcttc tcgagcttct tgatggagga gaaaatctcg ctattcttat    11400

tcagtgtgtt gcggaagact tccagcacct cctcgtcgct ggtatagccc tcgccgtaga    11460

aggagaggct ttccctatcg gacaggactt gcttgtagag cggcttgaat ttcggcagtt    11520

tctgcttggt cttctgattg tacagattga tgtactcatt cagcccctta atcttctccc    11580

cggactctgt gacgaagccc ccgataatcg cgttgtacac gtcaatgccc tcttgtgtga    11640

gcacaaaatt aaagaactcc ccttcgaaga aatcctcgac gtcataatcg gaattgagaa    11700

tcttctcttt gatctcctgc acctcgtgct tatcgaagat cgcatccacc ttctcgaaaa    11760

tgtccatatt ggaaatgtag cgggtgaggt tctcgttgat acacctgaag gcgatgctgg    11820

tggacttggc ctcctcggag aacatatttt ccctgttatc aaagaagccg gtaaacgcgg    11880

ttgtgaaccc gttaaaggag ttcaccagcg cgatctcgtc cttgtcatcg agaaactctg    11940

ggaggatagt ttcgatgatg tctttcttga agaggctctt gtacccttca ttgcccttga    12000

acgctttggc gatttccttg cggaggttga tctccaggtt ctccagctcc ttgttctcct    12060

tctcggtgcg ggtctttttg cggaagaggg agatgtagtt gttgagattc ttgagtttga    12120

tgctgtgcag cacgtcgtta ataaagctga ggtagtacct atcgagcagc ttcttcacgc    12180

ccttgtagtc ttcggcgcgc ttctcgtctt ccaccaggag cctcttgttg tcgatgttct    12240

cctgggtctt gcccaccggg atcgctttaa acctgagggt tttggagagg ctgtaacagt    12300

ttgtaaactt ctccagcttg gacgccatac cctgtataat ccaaaacaaa gaaaaacaaa    12360

tgaatcaatc accaattttt cattgtgtgt acaacaaggt taaaagaata tgggttatga    12420

aaactggaag cagcagatca gcaattataa tcaattcaat ttacaacaga catcaaaaaa    12480

acttgctcat caaattctcc ctgacaatca ataaatcggg taaaaaatat ccatgtacta    12540

atctaattaa aggacgtatt ttttgaatca tacaatacaa aaatccaaat ctaaaaattt    12600

atatgaaccc ctaatcacaa tctaaagact gtctttgaaa aacaaaggat taaatcatac    12660

aataaacagt aaaatcaagt aaacggttca attcagaagg atttcaatca gatgaaagaa    12720

aagaacaaaa ccctaattga atttaaattt gacggatcaa aagaaaagat cgattaaacg    12780

atagtagcta ataataataa aataatcgaa gaatagaaag tagattatac cttgaaacgg    12840

aattgggtgc taggtttgaa tgaatctctt ttccaaagga accggttttg tagcgatggg    12900

gaagaaaaga atgaagaagt ttagtttacc tgatttgctt ttatagcaaa aatcgattgg    12960

ctgttatatt acgccaacgg cacctcttcc aattaaaacg tgacacgtgg acaaactgtg    13020

acttgttacc taaccctttg tgatacgaca acgtttggta taagagagtc cacgtctatt    13080

atatgctgtc ttgcaccgcc tcgagacaat tcttctaact aagatcgatt gtgatacagg    13140

tgcgggtaca atacaatacg ggtacgtgaa ttagcggttt ttaaaaaaaa attaagatac    13200

gatacggtaa tgacttatga tacgttaaca atgatttata ataaaactta tatttgaaga    13260

aaaattaaca ctgattactc tttattattg tattattata aaagatacaa tttttaaaaa    13320

atagtacatg tgattattaa aataaatttt ttaaaaattt tcttataaat catattacat    13380

tttcatatga tgtgatattg agagaaacat cattaaaaga acttaacatt aattttattt    13440

aatgttgtct aactgaatca cctctctcgc tacgttcttc cacaagaaat ataattttaa    13500

gtgtttcatc gagaatcaat tatactgatg catatctaaa attgaatcat atacatttat    13560

aatgaatttt tacaacattg tctcactttt ttactcttca tgtttttcta ggatacgtat    13620

ctataaagta tcttagaaat atccttgtgt atatgtagag tatcacataa gtatccgata    13680

aaatatttat taaaaattaa aataattaat atgatacttc gtgcgtacgt atccgatatg    13740

agtaagtctc tgtattgaag tatacaggtt tcatagctga tacatctctt tcacggtttt    13800

gtctaatgta cccaaatcat aagtaaaata gtattgcgtc ataaactagt gtgtgttttt    13860

tattttcacg tgtccgtctt ttcgtttttt tagtgcgctg acgtttaaaa attattaaca    13920

gtggcgcgcc tagctaacta gctagccacg tgactcgcag aacgttgtgt ggcgagacgg    13980

aaagaaagtc acgcctccaa agagtgcagc atctcttctg gctctcacgg tcctctgtgg    14040

atccatcgat atcgaattcc tgcaggctcg aggtcattca tatgcttgag aagagagtcg    14100

ggatagtcca aaataaaaca aaggtaagat tacctggtca aaagtgaaaa catcagttaa    14160

aaggtggtat aaagtaaaat atcggtaata aaaggtggcc caaagtgaaa tttactcttt    14220

tctactatta taaaaattga ggatgttttt gtcggtactt tgatacgtca tttttgtatg    14280

aattggtttt taagtttatt cgcttttgga aatgcatatc tgtatttgag tcgggtttta    14340

agttcgtttg cttttgtaaa tacagaggga tttgtataag aaatatcttt agaaaaaccc    14400

atatgctaat ttgacataat ttttgagaaa aatatatatt caggcgaatt ctcacaatga    14460

acaataataa gattaaaata gctttccccc gttgcagcgc atgggtattt tttctagtaa    14520

aaataaaaga taaacttaga ctcaaaacat ttacaaaaac aacccctaaa gttcctaaag    14580

cccaaagtgc tatccacgat ccatagcaag cccagcccaa cccaacccaa cccaacccac    14640

cccagtccag ccaactggac aatagtctcc acaccccccc actatcaccg tgagttgtcc    14700

gcacgcaccg cacgtctcgc agccaaaaaa aaaaagaaag aaaaaaaaga aaaagaaaaa    14760

acagcaggtg ggtccgggtc gtgggggccg gaaacgcgag gaggatcgcg agccagcgac    14820

gaggagctta ggcctcatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc    14880

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt    14940

ggattgatgt gatatctcca ctgacgtaag ggatgacgca caatcccact atccttcgag    15000

gcctcatcgt tgaagatgcc tctgccgaca gtggtcccaa agatggaccc ccacccacga    15060

ggagcatcgt ggaaaaagaa gacgttccaa ccacgtcttc aaagcaagtg gattgatgtg    15120

atatctccac tgacgtaagg gatgacgcac aatcccacta tccttcgaag ctccctccct    15180

ccgcttccaa agaaacgccc cccatcgcca ctatatacat acccccccct ctcctcccat    15240

ccccccaacc cttctagaac catcttccac acactcaagc cacactattg gagaacacac    15300

agggacaaca caccataaga tccaagggag gcctccgccg ccgccggtaa ccaccccgcc    15360

cctctcctct ttctttctcc gttttttttt ccgtctcggt ctcgatcttt ggccttggta    15420

gtttgggtgg gcgagaggcg gcttcgtgcg cgcccagatc ggtgcgcggg aggggcggga    15480

tctcgcggct ggggctctcg ccggcgtgga tccggcccgg atctcgcggg gaatggggct    15540

ctcggatgta gatctgcgat ccgccgttgt tgggggagat gatggggggt ttaaaatttc    15600

cgccgtgcta aacaagatca ggaagagggg aaaagggcac tatggtttat atttttatat    15660

atttctgctg cttcgtcagg cttagatgtg ctagatcttt ctttcttctt tttgtgggta    15720

gaatttgaat ccctcagcat tgttcatcgg tagtttttct tttcatgatt tgtgacaaat    15780

gcagcctcgt gcggagcttt tttgtaggta gaaggcggcc gcatggccca gtctaagcac    15840

gggttgacga aggagatgac tatgaagtat cgcatggaag gctgcgttga cggccacaaa    15900

ttcgtcatta ccggcgaggg catcggctac ccctttaagg taagtttctg cttctacctt    15960

tgatatatat ataataatta tcattaatta gtagtaatat aatatttcaa atattttttt    16020

caaaataaaa gaatgtagta tatagcaatt gcttttctgt agtttataag tgtgtatatt    16080

ttaatttata acttttctaa tatatgacca aaatttgttg atgtgcaggg caagcaagcg    16140

ataaacctgt gcgtggtgga gggtggccct ctgcccttcg ccgaggatat actctcagcc    16200

gccttcatgt acgggaatcg ggtgttcacg gagtacccgc aagacatcgt ggactacttc    16260

aagaactcct gccccgccgg atacacatgg gaccgttcct tcctcttcga ggacggagcc    16320

gtttgcatct gcaacgcgga catcaccgtg tccgtcgagg agaactgcat gtaccacgag    16380

tcaaagttct atggagtgaa cttcccggcc gatggtcccg tgatgaagaa aatgacggac    16440

aactgggagc cgtcgtgcga gaaaatcatt cccgtcccaa aacagggaat cctcaagggc    16500

gacgtgtcga tgtacctact tctcaaggac ggtggacggc tacggtgcca gttcgacact    16560

gtttacaagg cgaagtcggt gccgaggaag atgccggact ggcactttat ccagcacaag    16620

ctgacaaggg aggacagaag cgacgctaag aaccagaaat ggcacctcac cgagcacgcc    16680

atcgccagtg gctctgcgct gcccgggtga ccctgcaatg tgaccctaga cttgtccatc    16740

ttctggattg gccaacttaa ttaatgtatg aaataaaagg atgcacacat agtgacatgc    16800

taatcactat aatgtgggca tcaaagttgt gtgttatgtg taattactaa ttatctgaat    16860

aagagaaaga gatcatccat atttcttatc ctaaatgaat gtcacgtgtc tttataattc    16920

tttgatgaac cagatgcatt ttattaacca attccatata catataaata ttaatcatat    16980

ataattaata tcaattgggt tagcaaaaca aatctagtct aggtgtgttt tgctaattat    17040

tgggggatag tgcaaaaaga aatctacgtt ctcaataatt cagatagaaa acttaataaa    17100

gtgagataat ttacatagat tgcttttatc ctttgatata tgtgaaacca tgcatgatat    17160

aaggaaaata gatagagaaa taatttttta catcgttgaa tatgtaaaca atttaattca    17220

agaagctagg aatataaata ttgaggagtt tatgattatt attattattt tgatgttcaa    17280

tgaagttttt tttaatttca tatgaagtat acaaaaattc ttcatagatt tttgtttcta    17340

tgccgtagtt atctttaata tatttgtggt tgaagaaatt tattgctaga aacgaatgga    17400

ttgtcaattt ttttttaaag caaatatata tgaaattata ctgtatatta ttttagtcat    17460

gattaaaatg tggccttaat tgaatcatct ttctcattca ttttttcaaa agcatatcag    17520

gatgattgat atttatctat tttaaaaatt aatttaaggg ttcaaattaa atttaactta    17580

aaagtgtcct aaccgtagtt aaaggtttac tttaaaaaaa tactatgaaa aatctaatct    17640

tctatgaatc gagggcccgg ccgtgacggc cacgagcgaa ctcctgcagg cgataaaaat    17700

gttttaaacg atatatatta taaaaaaaaa cgtttcaaaa ataaatacaa aaatgttttt    17760

aaatatatat aatttaactc attaaagaaa ataaaaatgc aagtgcggtg acaagacaag    17820

ctaaaagttg caaaagaaat ggcagggcta taaggctcac ctactcctgg atttaccaaa    17880

ttttggttcg tccctatact cgaaaaataa aacaaaataa atttcagtat cttcgttttt    17940

gtatgctttg actgtgaggc gaggccaact ttcttcttct gtctgagatg aattttgttt    18000

gcctcctgtg aaggatgtat cattcaaagt gaatgttttg caactgccag tagtcccaca    18060

tcgaccaaat attcttatta cagtgtgttt atatagcacc tggagaagga atgggttgtt    18120

tcaaagatta aataatttct actaagtgta gattgccgtt aatttgagag tccaagtaat    18180

ttctactaag tgtagatttt tttttgcggc cgcacaacaa acgcgccggc ga            18232


<210>  136
<211>  7267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3123 Full Plasmid Sequence

<400>  136
ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag atcccggtgc       60

ctaatgagtg agctaactta cattaattgc gttgcgcccc gggatgagat tatcaaaaag      120

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata      180

tgtgtaacat tggtctagtg attggatcct tgacagctag ctcagtccta ggtactgtgc      240

tagcgctagc aaagaggaga aaggtaccat gcccgatcga gctcaagtta tcattcgcat      300

tgtgccggga ggtggcacca agacccttca acaaattatc aatcagttgg agtatctatc      360

ccggaagggc aggctggagc tgcagcgttc agcccgacat ctcgatattc ccctgccacc      420

ggatcaaatc cacgaacttg cccgaagctg ggttcaagag actggaactt atgacgaaag      480

tcagccagac gaggaaaggc aacaggagtt gaccacccat attattgtaa gcttccccgc      540

cggtacaagc caggtagcgg cttatgcggc gagccgggag tgggcagccg agatgtttgg      600

gtcaggcgca ggggggggcc gatacaacta tcttacggcc ttccacatcg atcgcgacca      660

cccacatctg catgtcgtcg tcaatcggcg cgaactttta ggacacggct ggctgaagat      720

atctcggcgc catccccaac tgaattacga cgccctgcgc ataaagatgg ccgagatttc      780

acttcgtcat ggcattgccc tcgatgcgag ccgacgagca gaacgtggca tcaccgagcg      840

gccgatcact tatgcccaat atcggcgcct tgagcgggag caggctcgcc aaatccgttt      900

cgaagacgcg gatttggaac agtcgtcgcc gcaaggagat catccagaat tcagccaacc      960

tttcgataca tccccatttg aagcatccgc gggcggaccg gaggacatgc ctcggcccaa     1020

caatcggcag aatgagtcgc aagttcatct ccaggagcca gctggtgtca gcaacgaagc     1080

cggtgtcctt gtgcgggttg cattggaaac ggagcgcctt gctcaaccat tcgtttccga     1140

aaccattctc gcggacgaca tagggagcgg ctcttcgcgt gttgccgagg gccgtgtgga     1200

gagcgcaaac cgcactcccg atattcctcg cgcagcaact gaagctgcca cgcacacgac     1260

acacgaccgg cagcggcgtg caaagcgtcc tcatgatgac gacggagggc cgagtggagc     1320

aaaacgtgtg acattggaag gcatcgcggt tgggccccag gcgaacgccg gcgaacagga     1380

tggcagtagt gggggctcct cgggtggcag catgagcgga tcaaaaaaaa gaaggatcaa     1440

gcaagatccg ccgccagcgc tgccgcccaa gcgccgtcgc tccggcggta gcagcggtgg     1500

ttccccgccg ccggctctgc cgccgaagcg ccgtagaagc ggcggttcaa gcggtggctc     1560

tccgccaccg gcactgcctc cgaaacgtcg tcgttctggc ggtagcagcg gtggctcgcc     1620

gccgccggcg ttgccgccga aacgccgtcg ttccggtagt ggggggtcct ctggtggaag     1680

tagtggcccc ttagtacggc aagctggaac gtcacggcca tctccaccga cggccacgac     1740

gcgggccagc accgcaaccg attcattgtc tgctacagcc cacctccagc aacggagagg     1800

tgtcctttca aagcgtccgc gtgaagatga tgatggagaa ccgagtgaac gcaaacgcga     1860

gagagatgag cgcagcaagg acgggcgtgg gggaaatagg agatagtcta gaccaggcat     1920

caaataaaac gaaaggctca gtcgaaagac tgggcctttc gttttatctg ttgtttgtcg     1980

gtgaacgctc tctactagag tcacactggc tcaccttcgg gtgggccttt ctgcgtttat     2040

agtacgatat cccaatggcg cgccgagctt ggctcgagca tggtcatagc tgtttcctgt     2100

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa     2160

agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc     2220

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     2280

aggcggtttg cgtattgggc gctgttccgc ttcctcgctc actgactcgc tgcgctcggt     2340

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     2400

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     2460

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     2520

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     2580

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     2640

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     2700

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     2760

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     2820

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     2880

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     2940

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     3000

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     3060

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     3120

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     3180

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     3240

cagttagaaa aactcatcga gcatcaaatg aaactgcaat ttattcatat caggattatc     3300

aataccatat ttttgaaaaa gccgtttctg taatgaagga gaaaactcac cgaggcagtt     3360

ccataggatg gcaagatcct ggtatcggtc tgcgattccg actcgtccaa catcaataca     3420

acctattaat ttcccctcgt caaaaataag gttatcaagt gagaaatcac catgagtgac     3480

gactgaatcc ggtgagaatg gcaaaagttt atgcatttct ttccagactt gttcaacagg     3540

ccagccatta cgctcgtcat caaaatcact cgcatcaacc aaaccgttat tcattcgtga     3600

ttgcgcctga gcgaaacgaa atacgcgatc gctgttaaaa ggacaattac aaacaggaat     3660

cgaatgcaac cggcgcagga acactgccag cgcatcaaca atattttcac ctgaatcagg     3720

atattcttct aatacctgga atgctgtttt cccagggatc gcagtggtga gtaaccatgc     3780

atcatcagga gtacggataa aatgcttgat ggtcggaaga ggcataaatt ccgtcagcca     3840

gtttagtctg accatctcat ctgtaacatc attggcaacg ctacctttgc catgtttcag     3900

aaacaactct ggcgcatcgg gcttcccata caatcgatag attgtcgcac ctgattgccc     3960

gacattatcg cgagcccatt tatacccata taaatcagca tccatgttgg aatttaatcg     4020

cggcctagag caagacgttt cccgttgaat atggctcata ctcttccttt ttcaatatta     4080

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     4140

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga     4200

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc ccttttgtct     4260

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agactgtcac     4320

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt     4380

tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca     4440

ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcaggcgcca     4500

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     4560

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     4620

ttcccagtca cgacgttgta aaacgacggc cagtgaattg acgcgttgcg gctgcatgaa     4680

atcctggccg gtttgtctga tgccaagctg gcggcctggc cggccagctt ggccgctgaa     4740

gaaaccgagc gccgccgtct aaaaaggtga tgtgtatttg agtaaaacag cttgcgtcat     4800

gcggtcgctg cgtatatgat gcgatgagta aataaacaaa tacgcaaggg gaacgcatga     4860

aggttatcgc tgtacttaac cagaaaggcg ggtcaggcaa gacgaccatc gcaacccatc     4920

tagcccgcgc cctgcaactc gccggggccg atgttctgtt agtcgattcc gatccccagg     4980

gcagtgcccg cgattgggcg gccgtgcggg aagatcaacc gctaaccgtt gtcggcatcg     5040

accgcccgac gattgaccgc gacgtgaagg ccatcggccg gcgcgacttc gtagtgatcg     5100

acggagcgcc ccaggcggcg gacttggctg tgtccgcgat caaggcagcc gacttcgtgc     5160

tgattccggt gcagccaagc ccttacgaca tatgggccac cgccgacctg gtggagctgg     5220

ttaagcagcg cattgaggtc acggatggaa ggctacaagc ggcctttgtc gtgtcgcggg     5280

cgatcaaagg cacgcgcatc ggcggtgagg ttgccgaggc gctggccggg tacgagctgc     5340

ccattcttga gtcccgtatc acgcagcgcg tgagctaccc aggcactgcc gccgccggca     5400

caaccgttct tgaatcagaa cccgagggcg acgctgcccg cgaggtccag gcgctggccg     5460

ctgaaattaa atcaaaactc atttgagtta atgaggtaaa gagaaaatga gcaaaagcac     5520

aaacacgcta agtgccggcc gtccgagcgc acgcagcagc aaggctgcaa cgttggccag     5580

cctggcagac acgccagcca tgaagcgggt caactttcag ttgccggcgg aggatcacac     5640

caagctgaag atgtacgcgg tacgccaagg caagaccatt accgagctgc tatctgaata     5700

catcgcgcag ctaccagagt aaatgagcaa atgaataaat gagtagatga attttagcgg     5760

ctaaaggagg cggcatggaa aatcaagaac aaccaggcac cgacgccgtg gaatgcccca     5820

tgtgtggagg aacgggcggt tggccaggcg taagcggctg ggttgtctgc cggccctgca     5880

atggcactgg aacccccaag cccgaggaat cggcgtgagc ggtcgcaaac catccggccc     5940

ggtacaaatc ggcgcggcgc tgggtgatga cctggtggag aagttgaagg ccgcgcaggc     6000

cgcccagcgg caacgcatcg aggcagaagc acgccccggt gaatcgtggc aagcggccgc     6060

tgatcgaatc cgcaaagaat cccggcaacc gccggcagcc ggtgcgccgt cgattaggaa     6120

gccgcccaag ggcgacgagc aaccagattt tttcgttccg atgctctatg acgtgggcac     6180

ccgcgatagt cgcagcatca tggacgtggc cgttttccgt ctgtcgaagc gtgaccgacg     6240

agctggcgag gtgatccgct acgagcttcc agacgggcac gtagaggttt ccgcagggcc     6300

ggccggcatg gccagtgtgt gggattacga cctggtactg atggcggttt cccatctaac     6360

cgaatccatg aaccgatacc gggaagggaa gggagacaag cccggccgcg tgttccgtcc     6420

acacgttgcg gacgtactca agttctgccg gcgagccgat ggcggaaagc agaaagacga     6480

cctggtagaa acctgcattc ggttaaacac cacgcacgtt gccatgcagc gtacgaagaa     6540

ggccaagaac ggccgcctgg tgacggtatc cgagggtgaa gccttgatta gccgctacaa     6600

gatcgtaaag agcgaaaccg ggcggccgga gtacatcgag atcgagctag ctgattggat     6660

gtaccgcgag atcacagaag gcaagaaccc ggacgtgctg acggttcacc ccgattactt     6720

tttgatcgat cccggcatcg gccgttttct ctaccgcctg gcacgccgcg ccgcaggcaa     6780

ggcagaagcc agatggttgt tcaagacgat ctacgaacgc agtggcagcg ccggagagtt     6840

caagaagttc tgtttcaccg tgcgcaagct gatcgggtca aatgacctgc cggagtacga     6900

tttgaaggag gaggcggggc aggctggccc gatcctagtc atgcgctacc gcaacctgat     6960

cgagggcgaa gcatccgccg gttcctaatg tacggagcag atgctagggc aaattgccct     7020

agcaggggaa aaaggtcgaa aaggtctctt tcctgtggat agcacgtaca ttgggaaccc     7080

aaagccgtac attgggaacc ggaacccgta cattgggaac ccaaagccgt acattgggaa     7140

ccggtcacac atgtaagtga ctgatataaa agagaaaaaa ggcgattttt ccgcctaaaa     7200

ctctttaaaa cttattaaaa ctcttaaaac ccgcctggcc tgtgcatatg ctagtcatgc     7260

cccgcgc                                                               7267


<210>  137
<211>  18472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3090 Full Plasmid Sequence

<400>  137
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccattgggat cctgcaggga gccactgaaa ttctgtaaga     8160

actacattcg ccgtgagttt gacataatca caacgagcca ctgaaatttt gtaaaaacta     8220

cacttaagag cttcaacaaa atcagtgtca cggtaatttt tgtcaaaatt cactaattca     8280

aaagctaatg ccaaaaattg gcaatgactc aactcaagaa tctcatcttc cacagggtaa     8340

gctgttacca taaggtgaga acataataga atttgataat tgaaattttg cattgcaagg     8400

cattattacc aagagaagtc tatgccaaag ccacaacact aaacagatgt attaagccca     8460

aagggagaca caaagaagct acaaacaagt acttattgct tttacatcat cacgataagc     8520

tttggttcag tactaacatc agcaattaaa aggccacaca ataagagatg ttctcatggt     8580

cataattgta attacagagc tcaataatga aagtatgaaa tcatgacaga gagccctttc     8640

agtgcttcac ggaggtctgc gcgtactcca gccactcctt gttggaaatg gcaattttca     8700

ccttgtcgag cttctcatcc tccgcctttt tgaactgccc gatggcccag agcactttcc     8760

tggcgatatt ataggccccg ttcgcatcgg cgttcttcgg gaggatcgca ttctcttgcg     8820

cctcatagtt gcgggagtcg taaaagatcc cgtcggagtt cttcaccggg ctgatgagga     8880

agtcgacgtc ggtgcgccct gtgatgctat tcctcatttg gagcatcagg gacatgaggg     8940

ccatgaagct ggagtaaaac gctttgtcgg actgctcaca gaggagggcg cgaatgtcgc     9000

cctgctggta attgatgccg tatttattga acagttcctt gtaggcggat gtcaggcaca     9060

cttcctccca gtcaaagacg ttattttttt ttggattcct gaagatgcgg atcctgttcc     9120

cgtaggagta cagcttccac ttcttgatgt aatccgcatc tgtgcggctg aagtttttgt     9180

agtcgagggc gaactcgaag aggtcctcct ccggcacata cataatgcgg tcgaaggagg     9240

agataaactt cttgctgtcg gcaatggagg tatactttgt cttcaggagg ttcacgaagc     9300

cggtgctcgg gtcaatcttg gaggtgagcc acgccgggat gtagaaaata aacccgttct     9360

gggtgctcat gctcttgaag ctctcgaact tgttggtgat ctgatagccc ttcagcgcgc     9420

cccctgtggc acacgggttg gacttcttat ccaccatata attgagtttg tcgatcagca     9480

ttttctcgaa tttctgatac acctgttttt ccaccttcac gcgggagttc ttgaacccag     9540

aatttaagtc ttcgagcgca atcacggcgt catatttctc caccagctcg cagatcttgt     9600

ggacgacttg ggaaatatag ccggccttta attctttgat attctcaatg gaggtccagt     9660

tttggcgggc ctcaaacctc tctttttctt tcttgtcgag caggctgtga tagtcggtct     9720

taatcctaat cccattgaag ttgttgataa tctcgttcag ggagtactgc tccacaatat     9780

tgcccttccc atccacgacc acgatataga gcagattgcg ctcgcccctg tcaatgccga     9840

tgacatacgg attgtcgtcg tgtttgagca gcaccctgac ctctgtatta attttgaaga     9900

tattctttgg gcacttatta atcgcaattg ggatgtgtaa ttcgtactgg tcttcgctga     9960

agcgtttgtc cttgtagacg tcgtaggaca gggtggtggt ctttttcgga ttgtccgggt    10020

tcttgttcgc gatcggggaa ttggctggat ggacgaccag ctcttccttc ttgagggagg    10080

ccctgcgcat gaataattcg gcgccgccgc tcagcctgat ttgcccgtgg ttgttctcgt    10140

caaagagcag tttgaagtac atggtgtgga ggtttggggt cccatggctc ttgtcggaaa    10200

agtccttgtt ataaatttgg aacatgtaga gcttgccctc ctcgacgagc ttgtcgactt    10260

ccttcttgct cgcggattca aaagaaactt tatacccttg ctcctccacc tccctgtaaa    10320

agcccgcgat gtctttgtac ttttctgtct cggagaagtt aaaatcgtac gcattggacc    10380

atttcgggta gcgggaaatg ctatccttga agaaatcaat gagcttgtgg cagtcgttga    10440

ggttaaacat gtcccccttc ttgaaggtcc cgtttttata gattttctga atatcctcgc    10500

ttggattgta gtaggccatc cacttcttgc tgaagaacac cttcgggagc atcttgttcg    10560

gacccggcag cagcttgtag ttgatctttt catagttgcc attgacgtcg tctttgtcga    10620

tcttctgcag gcacttcgcg tacttcttgt ccatgatggc cagatagtat ttggagccat    10680

agcggagaat tgtcgcgcgg tagtctgtct ctttatcctt gtcccagccc cccataaatt    10740

gcgggttctg gaagtacagc ttgaacttgt ctttggagta cggcttctgt gtcacgtagt    10800

tgcggatcgc gtcgtaaatg tggtcgacct tcagcaggat gtcgtacgcg aggacaaagt    10860

cgccatagaa ggactcatcc ctgttagttt ccttcccctc cccaaagaac gctttaatgt    10920

aattttcgaa ggacttcacg gagtcgagca ggtctttcat aatggccacc acggcgtcat    10980

tctttttgag ggacttctcg agcacaaagt cggcgtcgaa cagcttctcg ctggacccgt    11040

acactttata gatctcgtcg accttctgaa tgatgatttc cttcagcttc tcgacgacgg    11100

acagatccgc atcggcatac tcctggagct gttcgaggct gaaggagccg atttttttga    11160

aggacttcct gcgatcgtcc tcatacttct cggtcaccac cgccttcttc ttcaggtgga    11220

tgtcgtcgta ctcggcgttc cacttgtccc tgatgacgtt ccactcgcca aagatgtcct    11280

tggagatggt gctgatcgcc ggcccgttct tcacgaaaat cccggcggag ctgtactcgt    11340

caaagttctt aaagagcttc tcgagcttct tgatggagga gaaaatctcg ctattcttat    11400

tcagtgtgtt gcggaagact tccagcacct cctcgtcgct ggtatagccc tcgccgtaga    11460

aggagaggct ttccctatcg gacaggactt gcttgtagag cggcttgaat ttcggcagtt    11520

tctgcttggt cttctgattg tacagattga tgtactcatt cagcccctta atcttctccc    11580

cggactctgt gacgaagccc ccgataatcg cgttgtacac gtcaatgccc tcttgtgtga    11640

gcacaaaatt aaagaactcc ccttcgaaga aatcctcgac gtcataatcg gaattgagaa    11700

tcttctcttt gatctcctgc acctcgtgct tatcgaagat cgcatccacc ttctcgaaaa    11760

tgtccatatt ggaaatgtag cgggtgaggt tctcgttgat acacctgaag gcgatgctgg    11820

tggacttggc ctcctcggag aacatatttt ccctgttatc aaagaagccg gtaaacgcgg    11880

ttgtgaaccc gttaaaggag ttcaccagcg cgatctcgtc cttgtcatcg agaaactctg    11940

ggaggatagt ttcgatgatg tctttcttga agaggctctt gtacccttca ttgcccttga    12000

acgctttggc gatttccttg cggaggttga tctccaggtt ctccagctcc ttgttctcct    12060

tctcggtgcg ggtctttttg cggaagaggg agatgtagtt gttgagattc ttgagtttga    12120

tgctgtgcag cacgtcgtta ataaagctga ggtagtacct atcgagcagc ttcttcacgc    12180

ccttgtagtc ttcggcgcgc ttctcgtctt ccaccaggag cctcttgttg tcgatgttct    12240

cctgggtctt gcccaccggg atcgctttaa acctgagggt tttggagagg ctgtaacagt    12300

ttgtaaactt ctccagcttg gagctgccgg agccgccgga gccgccctcg ggcgtcgcgc    12360

tctcggaggt gcctggtgtc tcggaggagc cgtacttctc cacataaggg acaggaatca    12420

ttcctctctt cccttcagaa tcttcagcat tccaccattg ttcttctggt ttgtccctta    12480

ttcggaggat gtcacctttc ttgaagggca aatcctcttc atcattgccg ttaaaatcaa    12540

aaagggcacg aacatactct gccgccatac cctgtataat ccaaaacaaa gaaaaacaaa    12600

tgaatcaatc accaattttt cattgtgtgt acaacaaggt taaaagaata tgggttatga    12660

aaactggaag cagcagatca gcaattataa tcaattcaat ttacaacaga catcaaaaaa    12720

acttgctcat caaattctcc ctgacaatca ataaatcggg taaaaaatat ccatgtacta    12780

atctaattaa aggacgtatt ttttgaatca tacaatacaa aaatccaaat ctaaaaattt    12840

atatgaaccc ctaatcacaa tctaaagact gtctttgaaa aacaaaggat taaatcatac    12900

aataaacagt aaaatcaagt aaacggttca attcagaagg atttcaatca gatgaaagaa    12960

aagaacaaaa ccctaattga atttaaattt gacggatcaa aagaaaagat cgattaaacg    13020

atagtagcta ataataataa aataatcgaa gaatagaaag tagattatac cttgaaacgg    13080

aattgggtgc taggtttgaa tgaatctctt ttccaaagga accggttttg tagcgatggg    13140

gaagaaaaga atgaagaagt ttagtttacc tgatttgctt ttatagcaaa aatcgattgg    13200

ctgttatatt acgccaacgg cacctcttcc aattaaaacg tgacacgtgg acaaactgtg    13260

acttgttacc taaccctttg tgatacgaca acgtttggta taagagagtc cacgtctatt    13320

atatgctgtc ttgcaccgcc tcgagacaat tcttctaact aagatcgatt gtgatacagg    13380

tgcgggtaca atacaatacg ggtacgtgaa ttagcggttt ttaaaaaaaa attaagatac    13440

gatacggtaa tgacttatga tacgttaaca atgatttata ataaaactta tatttgaaga    13500

aaaattaaca ctgattactc tttattattg tattattata aaagatacaa tttttaaaaa    13560

atagtacatg tgattattaa aataaatttt ttaaaaattt tcttataaat catattacat    13620

tttcatatga tgtgatattg agagaaacat cattaaaaga acttaacatt aattttattt    13680

aatgttgtct aactgaatca cctctctcgc tacgttcttc cacaagaaat ataattttaa    13740

gtgtttcatc gagaatcaat tatactgatg catatctaaa attgaatcat atacatttat    13800

aatgaatttt tacaacattg tctcactttt ttactcttca tgtttttcta ggatacgtat    13860

ctataaagta tcttagaaat atccttgtgt atatgtagag tatcacataa gtatccgata    13920

aaatatttat taaaaattaa aataattaat atgatacttc gtgcgtacgt atccgatatg    13980

agtaagtctc tgtattgaag tatacaggtt tcatagctga tacatctctt tcacggtttt    14040

gtctaatgta cccaaatcat aagtaaaata gtattgcgtc ataaactagt gtgtgttttt    14100

tattttcacg tgtccgtctt ttcgtttttt tagtgcgctg acgtttaaaa attattaaca    14160

gtggcgcgcc tagctaacta gctagccacg tgactcgcag aacgttgtgt ggcgagacgg    14220

aaagaaagtc acgcctccaa agagtgcagc atctcttctg gctctcacgg tcctctgtgg    14280

atccatcgat atcgaattcc tgcaggctcg aggtcattca tatgcttgag aagagagtcg    14340

ggatagtcca aaataaaaca aaggtaagat tacctggtca aaagtgaaaa catcagttaa    14400

aaggtggtat aaagtaaaat atcggtaata aaaggtggcc caaagtgaaa tttactcttt    14460

tctactatta taaaaattga ggatgttttt gtcggtactt tgatacgtca tttttgtatg    14520

aattggtttt taagtttatt cgcttttgga aatgcatatc tgtatttgag tcgggtttta    14580

agttcgtttg cttttgtaaa tacagaggga tttgtataag aaatatcttt agaaaaaccc    14640

atatgctaat ttgacataat ttttgagaaa aatatatatt caggcgaatt ctcacaatga    14700

acaataataa gattaaaata gctttccccc gttgcagcgc atgggtattt tttctagtaa    14760

aaataaaaga taaacttaga ctcaaaacat ttacaaaaac aacccctaaa gttcctaaag    14820

cccaaagtgc tatccacgat ccatagcaag cccagcccaa cccaacccaa cccaacccac    14880

cccagtccag ccaactggac aatagtctcc acaccccccc actatcaccg tgagttgtcc    14940

gcacgcaccg cacgtctcgc agccaaaaaa aaaaagaaag aaaaaaaaga aaaagaaaaa    15000

acagcaggtg ggtccgggtc gtgggggccg gaaacgcgag gaggatcgcg agccagcgac    15060

gaggagctta ggcctcatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc    15120

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt    15180

ggattgatgt gatatctcca ctgacgtaag ggatgacgca caatcccact atccttcgag    15240

gcctcatcgt tgaagatgcc tctgccgaca gtggtcccaa agatggaccc ccacccacga    15300

ggagcatcgt ggaaaaagaa gacgttccaa ccacgtcttc aaagcaagtg gattgatgtg    15360

atatctccac tgacgtaagg gatgacgcac aatcccacta tccttcgaag ctccctccct    15420

ccgcttccaa agaaacgccc cccatcgcca ctatatacat acccccccct ctcctcccat    15480

ccccccaacc cttctagaac catcttccac acactcaagc cacactattg gagaacacac    15540

agggacaaca caccataaga tccaagggag gcctccgccg ccgccggtaa ccaccccgcc    15600

cctctcctct ttctttctcc gttttttttt ccgtctcggt ctcgatcttt ggccttggta    15660

gtttgggtgg gcgagaggcg gcttcgtgcg cgcccagatc ggtgcgcggg aggggcggga    15720

tctcgcggct ggggctctcg ccggcgtgga tccggcccgg atctcgcggg gaatggggct    15780

ctcggatgta gatctgcgat ccgccgttgt tgggggagat gatggggggt ttaaaatttc    15840

cgccgtgcta aacaagatca ggaagagggg aaaagggcac tatggtttat atttttatat    15900

atttctgctg cttcgtcagg cttagatgtg ctagatcttt ctttcttctt tttgtgggta    15960

gaatttgaat ccctcagcat tgttcatcgg tagtttttct tttcatgatt tgtgacaaat    16020

gcagcctcgt gcggagcttt tttgtaggta gaaggcggcc gcatggccca gtctaagcac    16080

gggttgacga aggagatgac tatgaagtat cgcatggaag gctgcgttga cggccacaaa    16140

ttcgtcatta ccggcgaggg catcggctac ccctttaagg taagtttctg cttctacctt    16200

tgatatatat ataataatta tcattaatta gtagtaatat aatatttcaa atattttttt    16260

caaaataaaa gaatgtagta tatagcaatt gcttttctgt agtttataag tgtgtatatt    16320

ttaatttata acttttctaa tatatgacca aaatttgttg atgtgcaggg caagcaagcg    16380

ataaacctgt gcgtggtgga gggtggccct ctgcccttcg ccgaggatat actctcagcc    16440

gccttcatgt acgggaatcg ggtgttcacg gagtacccgc aagacatcgt ggactacttc    16500

aagaactcct gccccgccgg atacacatgg gaccgttcct tcctcttcga ggacggagcc    16560

gtttgcatct gcaacgcgga catcaccgtg tccgtcgagg agaactgcat gtaccacgag    16620

tcaaagttct atggagtgaa cttcccggcc gatggtcccg tgatgaagaa aatgacggac    16680

aactgggagc cgtcgtgcga gaaaatcatt cccgtcccaa aacagggaat cctcaagggc    16740

gacgtgtcga tgtacctact tctcaaggac ggtggacggc tacggtgcca gttcgacact    16800

gtttacaagg cgaagtcggt gccgaggaag atgccggact ggcactttat ccagcacaag    16860

ctgacaaggg aggacagaag cgacgctaag aaccagaaat ggcacctcac cgagcacgcc    16920

atcgccagtg gctctgcgct gcccgggtga ccctgcaatg tgaccctaga cttgtccatc    16980

ttctggattg gccaacttaa ttaatgtatg aaataaaagg atgcacacat agtgacatgc    17040

taatcactat aatgtgggca tcaaagttgt gtgttatgtg taattactaa ttatctgaat    17100

aagagaaaga gatcatccat atttcttatc ctaaatgaat gtcacgtgtc tttataattc    17160

tttgatgaac cagatgcatt ttattaacca attccatata catataaata ttaatcatat    17220

ataattaata tcaattgggt tagcaaaaca aatctagtct aggtgtgttt tgctaattat    17280

tgggggatag tgcaaaaaga aatctacgtt ctcaataatt cagatagaaa acttaataaa    17340

gtgagataat ttacatagat tgcttttatc ctttgatata tgtgaaacca tgcatgatat    17400

aaggaaaata gatagagaaa taatttttta catcgttgaa tatgtaaaca atttaattca    17460

agaagctagg aatataaata ttgaggagtt tatgattatt attattattt tgatgttcaa    17520

tgaagttttt tttaatttca tatgaagtat acaaaaattc ttcatagatt tttgtttcta    17580

tgccgtagtt atctttaata tatttgtggt tgaagaaatt tattgctaga aacgaatgga    17640

ttgtcaattt ttttttaaag caaatatata tgaaattata ctgtatatta ttttagtcat    17700

gattaaaatg tggccttaat tgaatcatct ttctcattca ttttttcaaa agcatatcag    17760

gatgattgat atttatctat tttaaaaatt aatttaaggg ttcaaattaa atttaactta    17820

aaagtgtcct aaccgtagtt aaaggtttac tttaaaaaaa tactatgaaa aatctaatct    17880

tctatgaatc gagggcccgg ccgtgacggc cacgagcgaa ctcctgcagg cgataaaaat    17940

gttttaaacg atatatatta taaaaaaaaa cgtttcaaaa ataaatacaa aaatgttttt    18000

aaatatatat aatttaactc attaaagaaa ataaaaatgc aagtgcggtg acaagacaag    18060

ctaaaagttg caaaagaaat ggcagggcta taaggctcac ctactcctgg atttaccaaa    18120

ttttggttcg tccctatact cgaaaaataa aacaaaataa atttcagtat cttcgttttt    18180

gtatgctttg actgtgaggc gaggccaact ttcttcttct gtctgagatg aattttgttt    18240

gcctcctgtg aaggatgtat cattcaaagt gaatgttttg caactgccag tagtcccaca    18300

tcgaccaaat attcttatta cagtgtgttt atatagcacc tggagaagga atgggttgtt    18360

tcaaagatta aataatttct actaagtgta gattgccgtt aatttgagag tccaagtaat    18420

ttctactaag tgtagatttt tttttgcggc cgcacaacaa acgcgccggc ga            18472


<210>  138
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aadA specific primer for first strand synthesis

<400>  138
atttgccgac taccttggtg at                                                22


<210>  139
<211>  12796
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3899 Full Plasmid Sequence

<400>  139
cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccgaga gcgttcaccg       60

acaaacaaca gataaaacga aaggcccagt ctttcgactg agcctttcgt tttatttgat      120

gcctggttac ctcgaaagcc cgctgcgcga gcggtcacgc gatgaggcat ccagctccgc      180

tcgggtgcgg ttatagacct cattgatatt tttctcgaag gattcgtttg tcgtcagaag      240

gcccactgcg ttagggccgc ctctggcgag gctggccgaa gagccaccac tgctgccgcc      300

cgaatcctgt ttgatccgac gcttcttgct accagcagaa taaatgccgg agttcgcggc      360

aatagcggac gggatcggat ttccatcctt gaggaggccc tgcatcgcct tgacgatcaa      420

ttcgcagtcg gagttcgttg cgaatatcgg gatggtgagt tccatgttca ggtagctgcg      480

ccaggccgcc accggcagtt caacgccgcc cacggtctgc gtcgcaactt tgggaacctc      540

gaccttgatg gtgtacttcc gcttctgggc cgatgactgg cggacggagc aggtcacttt      600

atacgcttgg gaccgcgagt tgctggagat ccattccgcc actccattgg caaaattcga      660

gggggctacg gtgacatcac ccgtaccgcc gttgtcgacc aggacgaatt gagtgaaatt      720

gctggcgtcc tgcttgatgc ggcgcttctt ggacccgctc atggtacctc cccatctccc      780

caagctcata accaacacag ccacttcggt cggaagaaat gctgtcatct gatgttcacg      840

attatcggga gggtcggtta ctctaggatt tttgttttct tcttttcgat ttcatttgaa      900

gcgaaaacgg ctttccatgc acttaagggt gcgccgacga aagatggctc tctaagacaa      960

cggcgaggat ctagaatgcc gtcgaagtga aattccaggg cggaatgaac gggggatggt     1020

tccaataaac tgtggcactt cgcaggctcc gatcagggtg tcgatcgcgc catttgcgtg     1080

gcgagggtat ccgcctatgc cgactatcct atgtccgagc tcagcgaaca tatgtcttgt     1140

tcttcgaaga cggtatcgaa gacctccagc agataatcgc caaccttcgg gtctcagaag     1200

acgcaccgcc acaaccgact gcccaaagcg attgcgagaa accatagcta taggcgcgcc     1260

gaacagacgt gctgattacc ctggtcgagt ctccttaatt aacaaaaaac ccctcaagac     1320

ccgtttagag gccccaaggg gttatgctag ttattgctca gcggaatcta cacttagtag     1380

aaattaggga acacgagcga catgggtgat cctcatgtcg ctcgtggcac atgggtgatc     1440

ctcatgtgct ccccttggac tctcaaatta acggcaatct acacttagta gaaattattt     1500

aatctttgaa acgctagcat tatacctagg actgagctag ctgtcaacaa ttggggatga     1560

gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa     1620

tctaaagtat atatgtgtaa cattggtcta gtgattggat ccggagactc gaccagggta     1680

atcagcacgt ctgttcggcg cgcctatagc tatggtttct cgcaatcgct ttgggcagtc     1740

ggttgtggcg gtgcgtcttc tgagacccga aggttggcga ttatctgctg gaggtcttcg     1800

ataccgtctt cgaagaacaa gacatatgtt cgctgagctc ggacatagga tagtcggcat     1860

aggcggatac cctcgccacg caaatggcgc gatcgacacc ctgatcggag cctgcgaagt     1920

gccacagttt attggaacca tcccccgttc attccgccct ggaatttcac ttcgacggca     1980

ttctagatcc tcgccgttgt cttagagagc catctttcgt cggcgcaccc ttaagtgcat     2040

ggaaagccgt tttcgcttca aatgaaatcg aaaagaagaa aacaaaaatc ctagagtaac     2100

cgaccctccc gataatcgtg aacatcagat gacagcattt cttccgaccg aagtggctgt     2160

gttggttatg agcttgggga gatggggagg taccatgagc ggctccaaga agcgccgcat     2220

caagcaagat tcaaagctgg agaagttcac caactgctac tcgctgagca agacgctgcg     2280

gttcaaggcc atccccgtgg gcaagaccca ggagaacatc gacaacaagc gcctcctggt     2340

cgaggacgag aagcgcgccg aggactacaa gggcgtcaag aagctcctgg accggtatta     2400

cctcagcttc atcaacgacg tgctgcactc gatcaagctc aagaacctga acaactacat     2460

cagcctgttc cgcaagaaaa cgcgcaccga gaaggagaac aaagagctgg agaacctgga     2520

gatcaacctg cggaaggaga ttgcgaaagc tttcaagggc aacgagggct acaagtcgct     2580

cttcaagaaa gacataatcg agaccatcct gccggagttc ctggacgaca aggacgagat     2640

cgcgctcgtc aactcgttca acgggttcac tacggccttc acgggtttct tcgataaccg     2700

ggagaatatg tttagcgagg aggccaagtc cacctccatt gcgttccgct gcatcaacga     2760

gaacctgacc cgctacatca gcaacatgga catcttcgag aaggtggacg ccatcttcga     2820

caagcacgag gtccaggaga tcaaggagaa gattctgaac tcggactacg acgtggaaga     2880

cttcttcgag ggcgagtttt tcaacttcgt cctgacccag gaggggatcg acgtttataa     2940

cgccatcatc ggcgggttcg tcacggagtc gggcgaaaag atcaagggcc tgaacgagta     3000

tattaacctg tacaaccaga agacaaagca gaagctgccg aagttcaagc cgctgtacaa     3060

gcaagtcctg tccgaccgcg agtcgctgtc gttctacggc gaaggctaca cctcggacga     3120

ggaggtgctg gaggtgttcc gcaacaccct gaacaagaat agcgaaattt ttagctccat     3180

taagaagctc gagaagctgt tcaagaactt cgacgagtac agcagcgccg ggatcttcgt     3240

caagaacggc cccgcgatca gcaccatctc gaaggacatc ttcggcgagt ggaacgtcat     3300

ccgggacaag tggaacgccg agtacgacga cattcacctt aaaaagaagg ctgttgtgac     3360

ggagaagtac gaggacgacc ggcgcaagtc gttcaaaaag atcggctcct tctccctgga     3420

gcagctccag gagtacgccg acgccgacct ctcggtcgtc gagaagctca aggagatcat     3480

cattcagaag gtggacgaaa tttacaaagt gtacggctcc agcgagaagc tgttcgacgc     3540

cgacttcgtg ctggaaaagt cgctcaagaa aaacgacgcc gtggtggcca tcatgaagga     3600

cttgctggac agcgtgaagt cgttcgagaa ctacattaag gcgttctttg gcgagggcaa     3660

ggagaccaac cgcgacgagt cgttctacgg cgacttcgtg ctcgcgtacg acatcctgct     3720

caaggtggat cacatctacg acgcgatccg caactacgtc acgcagaagc cgtactcgaa     3780

ggacaagttc aagctgtact tccagaaccc gcagttcatg ggcgggtggg acaaggacaa     3840

ggaaacggac taccgcgcga ccatcctgcg gtacggcagc aagtattatc tggcgatcat     3900

ggacaaaaaa tatgccaagt gcctccagaa aatcgacaag gacgacgtga acggcaacta     3960

cgagaagatt aattacaagc tgctccccgg ccccaacaag atgctcccga aggtgttctt     4020

tagcaagaag tggatggcct actacaaccc gagcgaggac atccagaaga tctataagaa     4080

tggcaccttc aagaagggag acatgtttaa cctcaacgac tgccacaagc tgattgactt     4140

cttcaaggac tcgatctcgc gctacccgaa gtggtcgaac gcctacgact tcaacttcag     4200

cgaaacggag aaatacaaag acatcgcggg cttctaccgc gaggtcgagg agcaaggcta     4260

caaggtcagc ttcgagtccg ccagcaagaa ggaggtggac aagctggtgg aggagggcaa     4320

gctctacatg tttcagatct acaacaagga ttttagcgac aagtcgcacg gcacgccgaa     4380

cctgcacacg atgtacttca agctgctgtt cgacgagaac aaccacggcc agatccggct     4440

gtcgggcggt gcggagctgt tcatgcgccg ggcgtcgctc aagaaggaag agctggtcgt     4500

ccacccggcc aacagcccca tcgccaacaa gaaccccgac aaccccaaga aaacgacgac     4560

actcagctat gatgtctata aagacaagcg cttctcggag gaccagtacg agctgcacat     4620

ccccatcgcc atcaacaagt gccccaagaa catcttcaag atcaacacgg aggtccgcgt     4680

gctcctcaag cacgacgaca acccgtacgt catcggcatc gaccggggcg agcgcaacct     4740

gctgtacatc gtcgtcgtcg atggcaaggg caacatcgtg gagcagtatt ccctgaacga     4800

gatcatcaac aacttcaacg gcatccgcat caagaccgac taccactccc tcctcgacaa     4860

gaaggagaaa gagcgcttcg aggcccgcca gaactggacc tccatcgaga acatcaagga     4920

gcttaaggcg ggctacatct cccaagtcgt ccacaagatc tgcgagctgg tcgagaagta     4980

cgacgcggtg atcgccctgg aagacctgaa ctccggcttc aagaactccc gcgtaaaggt     5040

ggagaagcaa gtgtaccaga agttcgagaa gatgctgatc gacaagctga actacatggt     5100

ggacaagaaa tcgaacccgt gcgcgaccgg cggcgcgctc aagggctacc agatcacgaa     5160

caagttcgag tcgttcaagt ccatgagcac gcagaacggc tttatcttct acatcccggc     5220

ctggctgacg tcgaagatcg acccctcgac cggcttcgtg aacctgctca agaccaagta     5280

tactagcatt gccgactcca agaaattcat ctcgtccttc gaccgcatca tgtacgtccc     5340

ggaggaggac ctttttgagt tcgccctcga ctacaagaac ttcagccgca ccgacgccga     5400

ctacatcaag aagtggaagc tgtactcgta cgggaaccgc atccgtattt ttcgcaaccc     5460

gaagaaaaat aatgtcttcg actgggagga ggtgtgcctg accagcgcct acaaggagct     5520

gttcaacaag tacggcatca actaccaaca gggcgacatc cgggcccttc tctgcgagca     5580

gagcgacaag gcgttctact cgtcgttcat ggccctgatg agcctgatgc tccagatgag     5640

gaacagcatc accggccgca ccgacgtgga cttcctcatc agccccgtca agaactcgga     5700

cggcatattt tatgactcgc ggaactacga ggcccaggag aacgccatcc tgcccaagaa     5760

cgccgacgcc aacggcgcgt acaacatcgc ccgcaaggtg ctctgggcca tcggccagtt     5820

caagaaggcg gaagacgaga agctggacaa ggtgaagatc gccatctcca acaaggagtg     5880

gctggagtac gcgcagacgt ccgtcaagca cggctccaag aaacggcgga tcaaacaaga     5940

ttccggtgga agttccggag gttcaagcgg gtctgaaacg ccgggcacca gcgagtcggc     6000

gaccccggaa agcagcggtg gttcttccgg cggtagcatg cccgatcgag ctcaagttat     6060

cattcgcatt gtgccgggag gtggcaccaa gacccttcaa caaattatca atcagttgga     6120

gtatctatcc cggaagggca ggctggagct gcagcgttca gcccgacatc tcgatattcc     6180

cctgccaccg gatcaaatcc acgaacttgc ccgaagctgg gttcaagaga ctggaactta     6240

tgacgaaagt cagccagacg aggaaaggca acaggagttg accacccata ttattgtaag     6300

cttccccgcc ggtacaagcc aggtagcggc ttatgcggcg agccgggagt gggcagccga     6360

gatgtttggg tcaggcgcag gggggggccg atacaactat cttacggcct tccacatcga     6420

tcgcgaccac ccacatctgc atgtcgtcgt caatcggcgc gaacttttag gacacggctg     6480

gctgaagata tctcggcgcc atccccaact gaattacgac gccctgcgca taaagatggc     6540

cgagatttca cttcgtcatg gcattgccct cgatgcgagc cgacgagcag aacgtggcat     6600

caccgagcgg ccgatcactt atgcccaata tcggcgcctt gagcgggagc aggctcgcca     6660

aatccgtttc gaagacgcgg atttggaaca gtcgtcgccg caaggagatc atccagaatt     6720

cagccaacct ttcgatacat ccccatttga agcatccgcg ggcggaccgg aggacatgcc     6780

tcggcccaac aatcggcaga atgagtcgca agttcatctc caggagccag ctggtgtcag     6840

caacgaagcc ggtgtccttg tgcgggttgc attggaaacg gagcgccttg ctcaaccatt     6900

cgtttccgaa accattctcg cggacgacat agggagcggc tcttcgcgtg ttgccgaggg     6960

ccgtgtggag agcgcaaacc gcactcccga tattcctcgc gcagcaactg aagctgccac     7020

gcacacgaca cacgaccggc agcggcgtgc aaagcgtcct catgatgacg acggagggcc     7080

gagtggagca aaacgtgtga cattggaagg catcgcggtt gggccccagg cgaacgccgg     7140

cgaacaggat ggcagtagtg gccccttagt acggcaagct ggaacgtcac ggccatctcc     7200

accgacggcc acgacgcggg ccagcaccgc aaccgattca ttgtctgcta cagcccacct     7260

ccagcaacgg agaggtgtcc tttcaaagcg tccgcgtgaa gatgatgatg gagaaccgag     7320

tgaacgcaaa cgcgagagag atgagcgcag caaggacggg cgtgggggaa ataggagata     7380

gtctagacca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt     7440

atctgttgtt tgtcggtgaa cgctctctac tagagtcaca ctggctcacc ttcgggtggg     7500

cctttctgcg tttatagtac gatatcccaa tggcgcgccg agcttggctc gagcatggtc     7560

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg     7620

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt     7680

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg     7740

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct cgctcactga     7800

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     7860

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     7920

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     7980

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     8040

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     8100

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     8160

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     8220

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     8280

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     8340

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     8400

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     8460

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     8520

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     8580

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     8640

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     8700

gtaaacttgg tctgacagtt agaaaaactc atcgagcatc aaatgaaact gcaatttatt     8760

catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa     8820

ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg     8880

tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa     8940

atcaccatga gtgacgactg aatccggtga gaatggcaaa agtttatgca tttctttcca     9000

gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc     9060

gttattcatt cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt taaaaggaca     9120

attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt     9180

ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccag ggatcgcagt     9240

ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat     9300

aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc     9360

tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt     9420

cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat     9480

gttggaattt aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc tcatactctt     9540

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     9600

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     9660

acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac     9720

gaggcccttt tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct     9780

cccggagact gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg     9840

cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat     9900

tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata     9960

ccgcatcagg cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg    10020

ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg    10080

ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgacgcg    10140

ttgcggctgc atgaaatcct ggccggtttg tctgatgcca agctggcggc ctggccggcc    10200

agcttggccg ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt atttgagtaa    10260

aacagcttgc gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa acaaatacgc    10320

aaggggaacg catgaaggtt atcgctgtac ttaaccagaa aggcgggtca ggcaagacga    10380

ccatcgcaac ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt ctgttagtcg    10440

attccgatcc ccagggcagt gcccgcgatt gggcggccgt gcgggaagat caaccgctaa    10500

ccgttgtcgg catcgaccgc ccgacgattg accgcgacgt gaaggccatc ggccggcgcg    10560

acttcgtagt gatcgacgga gcgccccagg cggcggactt ggctgtgtcc gcgatcaagg    10620

cagccgactt cgtgctgatt ccggtgcagc caagccctta cgacatatgg gccaccgccg    10680

acctggtgga gctggttaag cagcgcattg aggtcacgga tggaaggcta caagcggcct    10740

ttgtcgtgtc gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc gaggcgctgg    10800

ccgggtacga gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc tacccaggca    10860

ctgccgccgc cggcacaacc gttcttgaat cagaacccga gggcgacgct gcccgcgagg    10920

tccaggcgct ggccgctgaa attaaatcaa aactcatttg agttaatgag gtaaagagaa    10980

aatgagcaaa agcacaaaca cgctaagtgc cggccgtccg agcgcacgca gcagcaaggc    11040

tgcaacgttg gccagcctgg cagacacgcc agccatgaag cgggtcaact ttcagttgcc    11100

ggcggaggat cacaccaagc tgaagatgta cgcggtacgc caaggcaaga ccattaccga    11160

gctgctatct gaatacatcg cgcagctacc agagtaaatg agcaaatgaa taaatgagta    11220

gatgaatttt agcggctaaa ggaggcggca tggaaaatca agaacaacca ggcaccgacg    11280

ccgtggaatg ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc ggctgggttg    11340

tctgccggcc ctgcaatggc actggaaccc ccaagcccga ggaatcggcg tgagcggtcg    11400

caaaccatcc ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg tggagaagtt    11460

gaaggccgcg caggccgccc agcggcaacg catcgaggca gaagcacgcc ccggtgaatc    11520

gtggcaagcg gccgctgatc gaatccgcaa agaatcccgg caaccgccgg cagccggtgc    11580

gccgtcgatt aggaagccgc ccaagggcga cgagcaacca gattttttcg ttccgatgct    11640

ctatgacgtg ggcacccgcg atagtcgcag catcatggac gtggccgttt tccgtctgtc    11700

gaagcgtgac cgacgagctg gcgaggtgat ccgctacgag cttccagacg ggcacgtaga    11760

ggtttccgca gggccggccg gcatggccag tgtgtgggat tacgacctgg tactgatggc    11820

ggtttcccat ctaaccgaat ccatgaaccg ataccgggaa gggaagggag acaagcccgg    11880

ccgcgtgttc cgtccacacg ttgcggacgt actcaagttc tgccggcgag ccgatggcgg    11940

aaagcagaaa gacgacctgg tagaaacctg cattcggtta aacaccacgc acgttgccat    12000

gcagcgtacg aagaaggcca agaacggccg cctggtgacg gtatccgagg gtgaagcctt    12060

gattagccgc tacaagatcg taaagagcga aaccgggcgg ccggagtaca tcgagatcga    12120

gctagctgat tggatgtacc gcgagatcac agaaggcaag aacccggacg tgctgacggt    12180

tcaccccgat tactttttga tcgatcccgg catcggccgt tttctctacc gcctggcacg    12240

ccgcgccgca ggcaaggcag aagccagatg gttgttcaag acgatctacg aacgcagtgg    12300

cagcgccgga gagttcaaga agttctgttt caccgtgcgc aagctgatcg ggtcaaatga    12360

cctgccggag tacgatttga aggaggaggc ggggcaggct ggcccgatcc tagtcatgcg    12420

ctaccgcaac ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg agcagatgct    12480

agggcaaatt gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg tggatagcac    12540

gtacattggg aacccaaagc cgtacattgg gaaccggaac ccgtacattg ggaacccaaa    12600

gccgtacatt gggaaccggt cacacatgta agtgactgat ataaaagaga aaaaaggcga    12660

tttttccgcc taaaactctt taaaacttat taaaactctt aaaacccgcc tggcctgtgc    12720

atatgctagt catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg    12780

gcatcggtcg agatcc                                                    12796


<210>  140
<211>  12796
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3900 Full Plasmid Sequence

<400>  140
cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccgaga gcgttcaccg       60

acaaacaaca gataaaacga aaggcccagt ctttcgactg agcctttcgt tttatttgat      120

gcctggttac ctcgaaagcc cgctgcgcga gcggtcacgc gatgaggcat ccagctccgc      180

tcgggtgcgg ttatagacct cattgatatt tttctcgaag gattcgtttg tcgtcagaag      240

gcccactgcg ttagggccgc ctctggcgag gctggccgaa gagccaccac tgctgccgcc      300

cgaatcctgt ttgatccgac gcttcttgct accagcagaa taaatgccgg agttcgcggc      360

aatagcggac gggatcggat ttccatcctt gaggaggccc tgcatcgcct tgacgatcaa      420

ttcgcagtcg gagttcgttg cgaatatcgg gatggtgagt tccatgttca ggtagctgcg      480

ccaggccgcc accggcagtt caacgccgcc cacggtctgc gtcgcaactt tgggaacctc      540

gaccttgatg gtgtacttcc gcttctgggc cgatgactgg cggacggagc aggtcacttt      600

atacgcttgg gaccgcgagt tgctggagat ccattccgcc actccattgg caaaattcga      660

gggggctacg gtgacatcac ccgtaccgcc gttgtcgacc aggacgaatt gagtgaaatt      720

gctggcgtcc tgcttgatgc ggcgcttctt ggacccgctc atggtacctc cccatctccc      780

caagctcata accaacacag ccacttcggt cggaagaaat gctgtcatct gatgttcacg      840

attatcggga gggtcggtta ctctaggatt tttgttttct tcttttcgat ttcatttgaa      900

gcgaaaacgg ctttccatgc acttaagggt gcgccgacga aagatggctc tctaagacaa      960

cggcgaggat ctagaatgcc gtcgaagtga aattccaggg cggaatgaac gggggatggt     1020

tccaataaac tgtggcactt cgcaggctcc gatcagggtg tcgatcgcgc catttgcgtg     1080

gcgagggtat ccgcctatgc cgactatcct atgtccgagc tcagcgaaca tatgtcttgt     1140

tcttcgaaga cggtatcgaa gacctccagc agataatcgc caaccttcgg gtctcagaag     1200

acgcaccgcc acaaccgact gcccaaagcg attgcgagaa accatagcta taggcgcgcc     1260

gaacagacgt gctgattacc ctggtcgagt ctccttaatt aacaaaaaac ccctcaagac     1320

ccgtttagag gccccaaggg gttatgctag ttattgctca gcggaatcta cacttagtag     1380

aaattaggga acacgagcga catgggtgat cctcatgtcg ctcgtggcac atgggtgatc     1440

ctcatgtgct cccgctcgag gtcttcgttg ggaactatct acacttagta gaaattattt     1500

aatctttgaa acgctagcat tatacctagg actgagctag ctgtcaacaa ttggggatga     1560

gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa     1620

tctaaagtat atatgtgtaa cattggtcta gtgattggat ccggagactc gaccagggta     1680

atcagcacgt ctgttcggcg cgcctatagc tatggtttct cgcaatcgct ttgggcagtc     1740

ggttgtggcg gtgcgtcttc tgagacccga aggttggcga ttatctgctg gaggtcttcg     1800

ataccgtctt cgaagaacaa gacatatgtt cgctgagctc ggacatagga tagtcggcat     1860

aggcggatac cctcgccacg caaatggcgc gatcgacacc ctgatcggag cctgcgaagt     1920

gccacagttt attggaacca tcccccgttc attccgccct ggaatttcac ttcgacggca     1980

ttctagatcc tcgccgttgt cttagagagc catctttcgt cggcgcaccc ttaagtgcat     2040

ggaaagccgt tttcgcttca aatgaaatcg aaaagaagaa aacaaaaatc ctagagtaac     2100

cgaccctccc gataatcgtg aacatcagat gacagcattt cttccgaccg aagtggctgt     2160

gttggttatg agcttgggga gatggggagg taccatgagc ggctccaaga agcgccgcat     2220

caagcaagat tcaaagctgg agaagttcac caactgctac tcgctgagca agacgctgcg     2280

gttcaaggcc atccccgtgg gcaagaccca ggagaacatc gacaacaagc gcctcctggt     2340

cgaggacgag aagcgcgccg aggactacaa gggcgtcaag aagctcctgg accggtatta     2400

cctcagcttc atcaacgacg tgctgcactc gatcaagctc aagaacctga acaactacat     2460

cagcctgttc cgcaagaaaa cgcgcaccga gaaggagaac aaagagctgg agaacctgga     2520

gatcaacctg cggaaggaga ttgcgaaagc tttcaagggc aacgagggct acaagtcgct     2580

cttcaagaaa gacataatcg agaccatcct gccggagttc ctggacgaca aggacgagat     2640

cgcgctcgtc aactcgttca acgggttcac tacggccttc acgggtttct tcgataaccg     2700

ggagaatatg tttagcgagg aggccaagtc cacctccatt gcgttccgct gcatcaacga     2760

gaacctgacc cgctacatca gcaacatgga catcttcgag aaggtggacg ccatcttcga     2820

caagcacgag gtccaggaga tcaaggagaa gattctgaac tcggactacg acgtggaaga     2880

cttcttcgag ggcgagtttt tcaacttcgt cctgacccag gaggggatcg acgtttataa     2940

cgccatcatc ggcgggttcg tcacggagtc gggcgaaaag atcaagggcc tgaacgagta     3000

tattaacctg tacaaccaga agacaaagca gaagctgccg aagttcaagc cgctgtacaa     3060

gcaagtcctg tccgaccgcg agtcgctgtc gttctacggc gaaggctaca cctcggacga     3120

ggaggtgctg gaggtgttcc gcaacaccct gaacaagaat agcgaaattt ttagctccat     3180

taagaagctc gagaagctgt tcaagaactt cgacgagtac agcagcgccg ggatcttcgt     3240

caagaacggc cccgcgatca gcaccatctc gaaggacatc ttcggcgagt ggaacgtcat     3300

ccgggacaag tggaacgccg agtacgacga cattcacctt aaaaagaagg ctgttgtgac     3360

ggagaagtac gaggacgacc ggcgcaagtc gttcaaaaag atcggctcct tctccctgga     3420

gcagctccag gagtacgccg acgccgacct ctcggtcgtc gagaagctca aggagatcat     3480

cattcagaag gtggacgaaa tttacaaagt gtacggctcc agcgagaagc tgttcgacgc     3540

cgacttcgtg ctggaaaagt cgctcaagaa aaacgacgcc gtggtggcca tcatgaagga     3600

cttgctggac agcgtgaagt cgttcgagaa ctacattaag gcgttctttg gcgagggcaa     3660

ggagaccaac cgcgacgagt cgttctacgg cgacttcgtg ctcgcgtacg acatcctgct     3720

caaggtggat cacatctacg acgcgatccg caactacgtc acgcagaagc cgtactcgaa     3780

ggacaagttc aagctgtact tccagaaccc gcagttcatg ggcgggtggg acaaggacaa     3840

ggaaacggac taccgcgcga ccatcctgcg gtacggcagc aagtattatc tggcgatcat     3900

ggacaaaaaa tatgccaagt gcctccagaa aatcgacaag gacgacgtga acggcaacta     3960

cgagaagatt aattacaagc tgctccccgg ccccaacaag atgctcccga aggtgttctt     4020

tagcaagaag tggatggcct actacaaccc gagcgaggac atccagaaga tctataagaa     4080

tggcaccttc aagaagggag acatgtttaa cctcaacgac tgccacaagc tgattgactt     4140

cttcaaggac tcgatctcgc gctacccgaa gtggtcgaac gcctacgact tcaacttcag     4200

cgaaacggag aaatacaaag acatcgcggg cttctaccgc gaggtcgagg agcaaggcta     4260

caaggtcagc ttcgagtccg ccagcaagaa ggaggtggac aagctggtgg aggagggcaa     4320

gctctacatg tttcagatct acaacaagga ttttagcgac aagtcgcacg gcacgccgaa     4380

cctgcacacg atgtacttca agctgctgtt cgacgagaac aaccacggcc agatccggct     4440

gtcgggcggt gcggagctgt tcatgcgccg ggcgtcgctc aagaaggaag agctggtcgt     4500

ccacccggcc aacagcccca tcgccaacaa gaaccccgac aaccccaaga aaacgacgac     4560

actcagctat gatgtctata aagacaagcg cttctcggag gaccagtacg agctgcacat     4620

ccccatcgcc atcaacaagt gccccaagaa catcttcaag atcaacacgg aggtccgcgt     4680

gctcctcaag cacgacgaca acccgtacgt catcggcatc gaccggggcg agcgcaacct     4740

gctgtacatc gtcgtcgtcg atggcaaggg caacatcgtg gagcagtatt ccctgaacga     4800

gatcatcaac aacttcaacg gcatccgcat caagaccgac taccactccc tcctcgacaa     4860

gaaggagaaa gagcgcttcg aggcccgcca gaactggacc tccatcgaga acatcaagga     4920

gcttaaggcg ggctacatct cccaagtcgt ccacaagatc tgcgagctgg tcgagaagta     4980

cgacgcggtg atcgccctgg aagacctgaa ctccggcttc aagaactccc gcgtaaaggt     5040

ggagaagcaa gtgtaccaga agttcgagaa gatgctgatc gacaagctga actacatggt     5100

ggacaagaaa tcgaacccgt gcgcgaccgg cggcgcgctc aagggctacc agatcacgaa     5160

caagttcgag tcgttcaagt ccatgagcac gcagaacggc tttatcttct acatcccggc     5220

ctggctgacg tcgaagatcg acccctcgac cggcttcgtg aacctgctca agaccaagta     5280

tactagcatt gccgactcca agaaattcat ctcgtccttc gaccgcatca tgtacgtccc     5340

ggaggaggac ctttttgagt tcgccctcga ctacaagaac ttcagccgca ccgacgccga     5400

ctacatcaag aagtggaagc tgtactcgta cgggaaccgc atccgtattt ttcgcaaccc     5460

gaagaaaaat aatgtcttcg actgggagga ggtgtgcctg accagcgcct acaaggagct     5520

gttcaacaag tacggcatca actaccaaca gggcgacatc cgggcccttc tctgcgagca     5580

gagcgacaag gcgttctact cgtcgttcat ggccctgatg agcctgatgc tccagatgag     5640

gaacagcatc accggccgca ccgacgtgga cttcctcatc agccccgtca agaactcgga     5700

cggcatattt tatgactcgc ggaactacga ggcccaggag aacgccatcc tgcccaagaa     5760

cgccgacgcc aacggcgcgt acaacatcgc ccgcaaggtg ctctgggcca tcggccagtt     5820

caagaaggcg gaagacgaga agctggacaa ggtgaagatc gccatctcca acaaggagtg     5880

gctggagtac gcgcagacgt ccgtcaagca cggctccaag aaacggcgga tcaaacaaga     5940

ttccggtgga agttccggag gttcaagcgg gtctgaaacg ccgggcacca gcgagtcggc     6000

gaccccggaa agcagcggtg gttcttccgg cggtagcatg cccgatcgag ctcaagttat     6060

cattcgcatt gtgccgggag gtggcaccaa gacccttcaa caaattatca atcagttgga     6120

gtatctatcc cggaagggca ggctggagct gcagcgttca gcccgacatc tcgatattcc     6180

cctgccaccg gatcaaatcc acgaacttgc ccgaagctgg gttcaagaga ctggaactta     6240

tgacgaaagt cagccagacg aggaaaggca acaggagttg accacccata ttattgtaag     6300

cttccccgcc ggtacaagcc aggtagcggc ttatgcggcg agccgggagt gggcagccga     6360

gatgtttggg tcaggcgcag gggggggccg atacaactat cttacggcct tccacatcga     6420

tcgcgaccac ccacatctgc atgtcgtcgt caatcggcgc gaacttttag gacacggctg     6480

gctgaagata tctcggcgcc atccccaact gaattacgac gccctgcgca taaagatggc     6540

cgagatttca cttcgtcatg gcattgccct cgatgcgagc cgacgagcag aacgtggcat     6600

caccgagcgg ccgatcactt atgcccaata tcggcgcctt gagcgggagc aggctcgcca     6660

aatccgtttc gaagacgcgg atttggaaca gtcgtcgccg caaggagatc atccagaatt     6720

cagccaacct ttcgatacat ccccatttga agcatccgcg ggcggaccgg aggacatgcc     6780

tcggcccaac aatcggcaga atgagtcgca agttcatctc caggagccag ctggtgtcag     6840

caacgaagcc ggtgtccttg tgcgggttgc attggaaacg gagcgccttg ctcaaccatt     6900

cgtttccgaa accattctcg cggacgacat agggagcggc tcttcgcgtg ttgccgaggg     6960

ccgtgtggag agcgcaaacc gcactcccga tattcctcgc gcagcaactg aagctgccac     7020

gcacacgaca cacgaccggc agcggcgtgc aaagcgtcct catgatgacg acggagggcc     7080

gagtggagca aaacgtgtga cattggaagg catcgcggtt gggccccagg cgaacgccgg     7140

cgaacaggat ggcagtagtg gccccttagt acggcaagct ggaacgtcac ggccatctcc     7200

accgacggcc acgacgcggg ccagcaccgc aaccgattca ttgtctgcta cagcccacct     7260

ccagcaacgg agaggtgtcc tttcaaagcg tccgcgtgaa gatgatgatg gagaaccgag     7320

tgaacgcaaa cgcgagagag atgagcgcag caaggacggg cgtgggggaa ataggagata     7380

gtctagacca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt     7440

atctgttgtt tgtcggtgaa cgctctctac tagagtcaca ctggctcacc ttcgggtggg     7500

cctttctgcg tttatagtac gatatcccaa tggcgcgccg agcttggctc gagcatggtc     7560

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg     7620

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt     7680

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg     7740

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct cgctcactga     7800

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     7860

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     7920

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     7980

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     8040

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     8100

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     8160

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     8220

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     8280

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     8340

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     8400

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     8460

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     8520

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     8580

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     8640

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     8700

gtaaacttgg tctgacagtt agaaaaactc atcgagcatc aaatgaaact gcaatttatt     8760

catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa     8820

ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg     8880

tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa     8940

atcaccatga gtgacgactg aatccggtga gaatggcaaa agtttatgca tttctttcca     9000

gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc     9060

gttattcatt cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt taaaaggaca     9120

attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt     9180

ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccag ggatcgcagt     9240

ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat     9300

aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc     9360

tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt     9420

cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat     9480

gttggaattt aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc tcatactctt     9540

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     9600

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     9660

acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac     9720

gaggcccttt tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct     9780

cccggagact gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg     9840

cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat     9900

tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata     9960

ccgcatcagg cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg    10020

ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg    10080

ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgacgcg    10140

ttgcggctgc atgaaatcct ggccggtttg tctgatgcca agctggcggc ctggccggcc    10200

agcttggccg ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt atttgagtaa    10260

aacagcttgc gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa acaaatacgc    10320

aaggggaacg catgaaggtt atcgctgtac ttaaccagaa aggcgggtca ggcaagacga    10380

ccatcgcaac ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt ctgttagtcg    10440

attccgatcc ccagggcagt gcccgcgatt gggcggccgt gcgggaagat caaccgctaa    10500

ccgttgtcgg catcgaccgc ccgacgattg accgcgacgt gaaggccatc ggccggcgcg    10560

acttcgtagt gatcgacgga gcgccccagg cggcggactt ggctgtgtcc gcgatcaagg    10620

cagccgactt cgtgctgatt ccggtgcagc caagccctta cgacatatgg gccaccgccg    10680

acctggtgga gctggttaag cagcgcattg aggtcacgga tggaaggcta caagcggcct    10740

ttgtcgtgtc gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc gaggcgctgg    10800

ccgggtacga gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc tacccaggca    10860

ctgccgccgc cggcacaacc gttcttgaat cagaacccga gggcgacgct gcccgcgagg    10920

tccaggcgct ggccgctgaa attaaatcaa aactcatttg agttaatgag gtaaagagaa    10980

aatgagcaaa agcacaaaca cgctaagtgc cggccgtccg agcgcacgca gcagcaaggc    11040

tgcaacgttg gccagcctgg cagacacgcc agccatgaag cgggtcaact ttcagttgcc    11100

ggcggaggat cacaccaagc tgaagatgta cgcggtacgc caaggcaaga ccattaccga    11160

gctgctatct gaatacatcg cgcagctacc agagtaaatg agcaaatgaa taaatgagta    11220

gatgaatttt agcggctaaa ggaggcggca tggaaaatca agaacaacca ggcaccgacg    11280

ccgtggaatg ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc ggctgggttg    11340

tctgccggcc ctgcaatggc actggaaccc ccaagcccga ggaatcggcg tgagcggtcg    11400

caaaccatcc ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg tggagaagtt    11460

gaaggccgcg caggccgccc agcggcaacg catcgaggca gaagcacgcc ccggtgaatc    11520

gtggcaagcg gccgctgatc gaatccgcaa agaatcccgg caaccgccgg cagccggtgc    11580

gccgtcgatt aggaagccgc ccaagggcga cgagcaacca gattttttcg ttccgatgct    11640

ctatgacgtg ggcacccgcg atagtcgcag catcatggac gtggccgttt tccgtctgtc    11700

gaagcgtgac cgacgagctg gcgaggtgat ccgctacgag cttccagacg ggcacgtaga    11760

ggtttccgca gggccggccg gcatggccag tgtgtgggat tacgacctgg tactgatggc    11820

ggtttcccat ctaaccgaat ccatgaaccg ataccgggaa gggaagggag acaagcccgg    11880

ccgcgtgttc cgtccacacg ttgcggacgt actcaagttc tgccggcgag ccgatggcgg    11940

aaagcagaaa gacgacctgg tagaaacctg cattcggtta aacaccacgc acgttgccat    12000

gcagcgtacg aagaaggcca agaacggccg cctggtgacg gtatccgagg gtgaagcctt    12060

gattagccgc tacaagatcg taaagagcga aaccgggcgg ccggagtaca tcgagatcga    12120

gctagctgat tggatgtacc gcgagatcac agaaggcaag aacccggacg tgctgacggt    12180

tcaccccgat tactttttga tcgatcccgg catcggccgt tttctctacc gcctggcacg    12240

ccgcgccgca ggcaaggcag aagccagatg gttgttcaag acgatctacg aacgcagtgg    12300

cagcgccgga gagttcaaga agttctgttt caccgtgcgc aagctgatcg ggtcaaatga    12360

cctgccggag tacgatttga aggaggaggc ggggcaggct ggcccgatcc tagtcatgcg    12420

ctaccgcaac ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg agcagatgct    12480

agggcaaatt gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg tggatagcac    12540

gtacattggg aacccaaagc cgtacattgg gaaccggaac ccgtacattg ggaacccaaa    12600

gccgtacatt gggaaccggt cacacatgta agtgactgat ataaaagaga aaaaaggcga    12660

tttttccgcc taaaactctt taaaacttat taaaactctt aaaacccgcc tggcctgtgc    12720

atatgctagt catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg    12780

gcatcggtcg agatcc                                                    12796


<210>  141
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin left flank primer

<400>  141
tgctcaggtc ctttagcaac tacctt                                            26


<210>  142
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polyubiquitin right flank primer

<400>  142
ggagaaacat gtgagtagac cactt                                             25


<210>  143
<211>  11481
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3897 Full Plasmid Sequence

<400>  143
cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccttaa ttaacaaaaa       60

acccctcaag acccgtttag aggccccaag gggttatgct agttattgct cagcggaatc      120

tacacttagt agaaattata tccacatgtg tttttagtaa aatctacact tagtagaaat      180

tatttaatct ttgaaacgct agcattatac ctaggactga gctagctgtc aacaattggg      240

gatgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa      300

atcaatctaa agtatatatg tgtaacattg gtctagtgat tggatccgga gactcgacca      360

gggtaatcag cacgtctgtt cggcgcgcct atagctatgg tttctcgcaa tcgctttggg      420

cagtcggttg tggcggtgcg tcttctgaga cccgaaggtt ggcgattatc tgctggaggt      480

cttcgatacc gtcttcgaag aacaagacat atgttcgctg agctcggaca taggatagtc      540

ggcataggcg gataccctcg ccacgcaaat ggcgcgatcg acaccctgat cggagcctgc      600

gaagtgccac agtttattgg aaccatcccc cgttcattcc gccctggaat ttcacttcga      660

cggcattcta gatcctcgcc gttgtcttag agagccatct ttcgtcggcg cacccttaag      720

tgcatggaaa gccgttttcg cttcaaatga aatcgaaaag aagaaaacaa aaatcctaga      780

gtaaccgacc ctcccgataa tcgtgaacat cagatgacag catttcttcc gaccgaagtg      840

gctgtgttgg ttatgagctt ggggagatgg ggaggtacca tgagcggctc caagaagcgc      900

cgcatcaagc aagattcaaa gctggagaag ttcaccaact gctactcgct gagcaagacg      960

ctgcggttca aggccatccc cgtgggcaag acccaggaga acatcgacaa caagcgcctc     1020

ctggtcgagg acgagaagcg cgccgaggac tacaagggcg tcaagaagct cctggaccgg     1080

tattacctca gcttcatcaa cgacgtgctg cactcgatca agctcaagaa cctgaacaac     1140

tacatcagcc tgttccgcaa gaaaacgcgc accgagaagg agaacaaaga gctggagaac     1200

ctggagatca acctgcggaa ggagattgcg aaagctttca agggcaacga gggctacaag     1260

tcgctcttca agaaagacat aatcgagacc atcctgccgg agttcctgga cgacaaggac     1320

gagatcgcgc tcgtcaactc gttcaacggg ttcactacgg ccttcacggg tttcttcgat     1380

aaccgggaga atatgtttag cgaggaggcc aagtccacct ccattgcgtt ccgctgcatc     1440

aacgagaacc tgacccgcta catcagcaac atggacatct tcgagaaggt ggacgccatc     1500

ttcgacaagc acgaggtcca ggagatcaag gagaagattc tgaactcgga ctacgacgtg     1560

gaagacttct tcgagggcga gtttttcaac ttcgtcctga cccaggaggg gatcgacgtt     1620

tataacgcca tcatcggcgg gttcgtcacg gagtcgggcg aaaagatcaa gggcctgaac     1680

gagtatatta acctgtacaa ccagaagaca aagcagaagc tgccgaagtt caagccgctg     1740

tacaagcaag tcctgtccga ccgcgagtcg ctgtcgttct acggcgaagg ctacacctcg     1800

gacgaggagg tgctggaggt gttccgcaac accctgaaca agaatagcga aatttttagc     1860

tccattaaga agctcgagaa gctgttcaag aacttcgacg agtacagcag cgccgggatc     1920

ttcgtcaaga acggccccgc gatcagcacc atctcgaagg acatcttcgg cgagtggaac     1980

gtcatccggg acaagtggaa cgccgagtac gacgacattc accttaaaaa gaaggctgtt     2040

gtgacggaga agtacgagga cgaccggcgc aagtcgttca aaaagatcgg ctccttctcc     2100

ctggagcagc tccaggagta cgccgacgcc gacctctcgg tcgtcgagaa gctcaaggag     2160

atcatcattc agaaggtgga cgaaatttac aaagtgtacg gctccagcga gaagctgttc     2220

gacgccgact tcgtgctgga aaagtcgctc aagaaaaacg acgccgtggt ggccatcatg     2280

aaggacttgc tggacagcgt gaagtcgttc gagaactaca ttaaggcgtt ctttggcgag     2340

ggcaaggaga ccaaccgcga cgagtcgttc tacggcgact tcgtgctcgc gtacgacatc     2400

ctgctcaagg tggatcacat ctacgacgcg atccgcaact acgtcacgca gaagccgtac     2460

tcgaaggaca agttcaagct gtacttccag aacccgcagt tcatgggcgg gtgggacaag     2520

gacaaggaaa cggactaccg cgcgaccatc ctgcggtacg gcagcaagta ttatctggcg     2580

atcatggaca aaaaatatgc caagtgcctc cagaaaatcg acaaggacga cgtgaacggc     2640

aactacgaga agattaatta caagctgctc cccggcccca acaagatgct cccgaaggtg     2700

ttctttagca agaagtggat ggcctactac aacccgagcg aggacatcca gaagatctat     2760

aagaatggca ccttcaagaa gggagacatg tttaacctca acgactgcca caagctgatt     2820

gacttcttca aggactcgat ctcgcgctac ccgaagtggt cgaacgccta cgacttcaac     2880

ttcagcgaaa cggagaaata caaagacatc gcgggcttct accgcgaggt cgaggagcaa     2940

ggctacaagg tcagcttcga gtccgccagc aagaaggagg tggacaagct ggtggaggag     3000

ggcaagctct acatgtttca gatctacaac aaggatttta gcgacaagtc gcacggcacg     3060

ccgaacctgc acacgatgta cttcaagctg ctgttcgacg agaacaacca cggccagatc     3120

cggctgtcgg gcggtgcgga gctgttcatg cgccgggcgt cgctcaagaa ggaagagctg     3180

gtcgtccacc cggccaacag ccccatcgcc aacaagaacc ccgacaaccc caagaaaacg     3240

acgacactca gctatgatgt ctataaagac aagcgcttct cggaggacca gtacgagctg     3300

cacatcccca tcgccatcaa caagtgcccc aagaacatct tcaagatcaa cacggaggtc     3360

cgcgtgctcc tcaagcacga cgacaacccg tacgtcatcg gcatcgaccg gggcgagcgc     3420

aacctgctgt acatcgtcgt cgtcgatggc aagggcaaca tcgtggagca gtattccctg     3480

aacgagatca tcaacaactt caacggcatc cgcatcaaga ccgactacca ctccctcctc     3540

gacaagaagg agaaagagcg cttcgaggcc cgccagaact ggacctccat cgagaacatc     3600

aaggagctta aggcgggcta catctcccaa gtcgtccaca agatctgcga gctggtcgag     3660

aagtacgacg cggtgatcgc cctggaagac ctgaactccg gcttcaagaa ctcccgcgta     3720

aaggtggaga agcaagtgta ccagaagttc gagaagatgc tgatcgacaa gctgaactac     3780

atggtggaca agaaatcgaa cccgtgcgcg accggcggcg cgctcaaggg ctaccagatc     3840

acgaacaagt tcgagtcgtt caagtccatg agcacgcaga acggctttat cttctacatc     3900

ccggcctggc tgacgtcgaa gatcgacccc tcgaccggct tcgtgaacct gctcaagacc     3960

aagtatacta gcattgccga ctccaagaaa ttcatctcgt ccttcgaccg catcatgtac     4020

gtcccggagg aggacctttt tgagttcgcc ctcgactaca agaacttcag ccgcaccgac     4080

gccgactaca tcaagaagtg gaagctgtac tcgtacggga accgcatccg tatttttcgc     4140

aacccgaaga aaaataatgt cttcgactgg gaggaggtgt gcctgaccag cgcctacaag     4200

gagctgttca acaagtacgg catcaactac caacagggcg acatccgggc ccttctctgc     4260

gagcagagcg acaaggcgtt ctactcgtcg ttcatggccc tgatgagcct gatgctccag     4320

atgaggaaca gcatcaccgg ccgcaccgac gtggacttcc tcatcagccc cgtcaagaac     4380

tcggacggca tattttatga ctcgcggaac tacgaggccc aggagaacgc catcctgccc     4440

aagaacgccg acgccaacgg cgcgtacaac atcgcccgca aggtgctctg ggccatcggc     4500

cagttcaaga aggcggaaga cgagaagctg gacaaggtga agatcgccat ctccaacaag     4560

gagtggctgg agtacgcgca gacgtccgtc aagcacggct ccaagaaacg gcggatcaaa     4620

caagattccg gtggaagttc cggaggttca agcgggtctg aaacgccggg caccagcgag     4680

tcggcgaccc cggaaagcag cggtggttct tccggcggta gcatgcccga tcgagctcaa     4740

gttatcattc gcattgtgcc gggaggtggc accaagaccc ttcaacaaat tatcaatcag     4800

ttggagtatc tatcccggaa gggcaggctg gagctgcagc gttcagcccg acatctcgat     4860

attcccctgc caccggatca aatccacgaa cttgcccgaa gctgggttca agagactgga     4920

acttatgacg aaagtcagcc agacgaggaa aggcaacagg agttgaccac ccatattatt     4980

gtaagcttcc ccgccggtac aagccaggta gcggcttatg cggcgagccg ggagtgggca     5040

gccgagatgt ttgggtcagg cgcagggggg ggccgataca actatcttac ggccttccac     5100

atcgatcgcg accacccaca tctgcatgtc gtcgtcaatc ggcgcgaact tttaggacac     5160

ggctggctga agatatctcg gcgccatccc caactgaatt acgacgccct gcgcataaag     5220

atggccgaga tttcacttcg tcatggcatt gccctcgatg cgagccgacg agcagaacgt     5280

ggcatcaccg agcggccgat cacttatgcc caatatcggc gccttgagcg ggagcaggct     5340

cgccaaatcc gtttcgaaga cgcggatttg gaacagtcgt cgccgcaagg agatcatcca     5400

gaattcagcc aacctttcga tacatcccca tttgaagcat ccgcgggcgg accggaggac     5460

atgcctcggc ccaacaatcg gcagaatgag tcgcaagttc atctccagga gccagctggt     5520

gtcagcaacg aagccggtgt ccttgtgcgg gttgcattgg aaacggagcg ccttgctcaa     5580

ccattcgttt ccgaaaccat tctcgcggac gacataggga gcggctcttc gcgtgttgcc     5640

gagggccgtg tggagagcgc aaaccgcact cccgatattc ctcgcgcagc aactgaagct     5700

gccacgcaca cgacacacga ccggcagcgg cgtgcaaagc gtcctcatga tgacgacgga     5760

gggccgagtg gagcaaaacg tgtgacattg gaaggcatcg cggttgggcc ccaggcgaac     5820

gccggcgaac aggatggcag tagtggcccc ttagtacggc aagctggaac gtcacggcca     5880

tctccaccga cggccacgac gcgggccagc accgcaaccg attcattgtc tgctacagcc     5940

cacctccagc aacggagagg tgtcctttca aagcgtccgc gtgaagatga tgatggagaa     6000

ccgagtgaac gcaaacgcga gagagatgag cgcagcaagg acgggcgtgg gggaaatagg     6060

agatagtcta gaccaggcat caaataaaac gaaaggctca gtcgaaagac tgggcctttc     6120

gttttatctg ttgtttgtcg gtgaacgctc tctactagag tcacactggc tcaccttcgg     6180

gtgggccttt ctgcgtttat agtacgatat cccaatggcg cgccgagctt ggctcgagca     6240

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     6300

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     6360

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     6420

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctgttccgc ttcctcgctc     6480

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     6540

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     6600

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     6660

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     6720

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     6780

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     6840

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     6900

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     6960

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     7020

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     7080

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     7140

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     7200

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     7260

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     7320

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     7380

tatgagtaaa cttggtctga cagttagaaa aactcatcga gcatcaaatg aaactgcaat     7440

ttattcatat caggattatc aataccatat ttttgaaaaa gccgtttctg taatgaagga     7500

gaaaactcac cgaggcagtt ccataggatg gcaagatcct ggtatcggtc tgcgattccg     7560

actcgtccaa catcaataca acctattaat ttcccctcgt caaaaataag gttatcaagt     7620

gagaaatcac catgagtgac gactgaatcc ggtgagaatg gcaaaagttt atgcatttct     7680

ttccagactt gttcaacagg ccagccatta cgctcgtcat caaaatcact cgcatcaacc     7740

aaaccgttat tcattcgtga ttgcgcctga gcgaaacgaa atacgcgatc gctgttaaaa     7800

ggacaattac aaacaggaat cgaatgcaac cggcgcagga acactgccag cgcatcaaca     7860

atattttcac ctgaatcagg atattcttct aatacctgga atgctgtttt cccagggatc     7920

gcagtggtga gtaaccatgc atcatcagga gtacggataa aatgcttgat ggtcggaaga     7980

ggcataaatt ccgtcagcca gtttagtctg accatctcat ctgtaacatc attggcaacg     8040

ctacctttgc catgtttcag aaacaactct ggcgcatcgg gcttcccata caatcgatag     8100

attgtcgcac ctgattgccc gacattatcg cgagcccatt tatacccata taaatcagca     8160

tccatgttgg aatttaatcg cggcctagag caagacgttt cccgttgaat atggctcata     8220

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     8280

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     8340

gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt     8400

atcacgaggc ccttttgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg     8460

cagctcccgg agactgtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt     8520

cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag     8580

cagattgtac tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga     8640

aaataccgca tcaggcgcca ttcgccattc aggctgcgca actgttggga agggcgatcg     8700

gtgcgggcct cttcgctatt acgccagctg gcgaaagggg gatgtgctgc aaggcgatta     8760

agttgggtaa cgccagggtt ttcccagtca cgacgttgta aaacgacggc cagtgaattg     8820

acgcgttgcg gctgcatgaa atcctggccg gtttgtctga tgccaagctg gcggcctggc     8880

cggccagctt ggccgctgaa gaaaccgagc gccgccgtct aaaaaggtga tgtgtatttg     8940

agtaaaacag cttgcgtcat gcggtcgctg cgtatatgat gcgatgagta aataaacaaa     9000

tacgcaaggg gaacgcatga aggttatcgc tgtacttaac cagaaaggcg ggtcaggcaa     9060

gacgaccatc gcaacccatc tagcccgcgc cctgcaactc gccggggccg atgttctgtt     9120

agtcgattcc gatccccagg gcagtgcccg cgattgggcg gccgtgcggg aagatcaacc     9180

gctaaccgtt gtcggcatcg accgcccgac gattgaccgc gacgtgaagg ccatcggccg     9240

gcgcgacttc gtagtgatcg acggagcgcc ccaggcggcg gacttggctg tgtccgcgat     9300

caaggcagcc gacttcgtgc tgattccggt gcagccaagc ccttacgaca tatgggccac     9360

cgccgacctg gtggagctgg ttaagcagcg cattgaggtc acggatggaa ggctacaagc     9420

ggcctttgtc gtgtcgcggg cgatcaaagg cacgcgcatc ggcggtgagg ttgccgaggc     9480

gctggccggg tacgagctgc ccattcttga gtcccgtatc acgcagcgcg tgagctaccc     9540

aggcactgcc gccgccggca caaccgttct tgaatcagaa cccgagggcg acgctgcccg     9600

cgaggtccag gcgctggccg ctgaaattaa atcaaaactc atttgagtta atgaggtaaa     9660

gagaaaatga gcaaaagcac aaacacgcta agtgccggcc gtccgagcgc acgcagcagc     9720

aaggctgcaa cgttggccag cctggcagac acgccagcca tgaagcgggt caactttcag     9780

ttgccggcgg aggatcacac caagctgaag atgtacgcgg tacgccaagg caagaccatt     9840

accgagctgc tatctgaata catcgcgcag ctaccagagt aaatgagcaa atgaataaat     9900

gagtagatga attttagcgg ctaaaggagg cggcatggaa aatcaagaac aaccaggcac     9960

cgacgccgtg gaatgcccca tgtgtggagg aacgggcggt tggccaggcg taagcggctg    10020

ggttgtctgc cggccctgca atggcactgg aacccccaag cccgaggaat cggcgtgagc    10080

ggtcgcaaac catccggccc ggtacaaatc ggcgcggcgc tgggtgatga cctggtggag    10140

aagttgaagg ccgcgcaggc cgcccagcgg caacgcatcg aggcagaagc acgccccggt    10200

gaatcgtggc aagcggccgc tgatcgaatc cgcaaagaat cccggcaacc gccggcagcc    10260

ggtgcgccgt cgattaggaa gccgcccaag ggcgacgagc aaccagattt tttcgttccg    10320

atgctctatg acgtgggcac ccgcgatagt cgcagcatca tggacgtggc cgttttccgt    10380

ctgtcgaagc gtgaccgacg agctggcgag gtgatccgct acgagcttcc agacgggcac    10440

gtagaggttt ccgcagggcc ggccggcatg gccagtgtgt gggattacga cctggtactg    10500

atggcggttt cccatctaac cgaatccatg aaccgatacc gggaagggaa gggagacaag    10560

cccggccgcg tgttccgtcc acacgttgcg gacgtactca agttctgccg gcgagccgat    10620

ggcggaaagc agaaagacga cctggtagaa acctgcattc ggttaaacac cacgcacgtt    10680

gccatgcagc gtacgaagaa ggccaagaac ggccgcctgg tgacggtatc cgagggtgaa    10740

gccttgatta gccgctacaa gatcgtaaag agcgaaaccg ggcggccgga gtacatcgag    10800

atcgagctag ctgattggat gtaccgcgag atcacagaag gcaagaaccc ggacgtgctg    10860

acggttcacc ccgattactt tttgatcgat cccggcatcg gccgttttct ctaccgcctg    10920

gcacgccgcg ccgcaggcaa ggcagaagcc agatggttgt tcaagacgat ctacgaacgc    10980

agtggcagcg ccggagagtt caagaagttc tgtttcaccg tgcgcaagct gatcgggtca    11040

aatgacctgc cggagtacga tttgaaggag gaggcggggc aggctggccc gatcctagtc    11100

atgcgctacc gcaacctgat cgagggcgaa gcatccgccg gttcctaatg tacggagcag    11160

atgctagggc aaattgccct agcaggggaa aaaggtcgaa aaggtctctt tcctgtggat    11220

agcacgtaca ttgggaaccc aaagccgtac attgggaacc ggaacccgta cattgggaac    11280

ccaaagccgt acattgggaa ccggtcacac atgtaagtga ctgatataaa agagaaaaaa    11340

ggcgattttt ccgcctaaaa ctctttaaaa cttattaaaa ctcttaaaac ccgcctggcc    11400

tgtgcatatg ctagtcatgc cccgcgccca ccggaaggag ctgactgggt tgaaggctct    11460

caagggcatc ggtcgagatc c                                              11481


<210>  144
<211>  11481
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3898 Full Plasmid Sequence

<400>  144
cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccttaa ttaacaaaaa       60

acccctcaag acccgtttag aggccccaag gggttatgct agttattgct cagcggaatc      120

tacacttagt agaaattaca tggagggcac agttaagccg catctacact tagtagaaat      180

tatttaatct ttgaaacgct agcattatac ctaggactga gctagctgtc aacaattggg      240

gatgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa      300

atcaatctaa agtatatatg tgtaacattg gtctagtgat tggatccgga gactcgacca      360

gggtaatcag cacgtctgtt cggcgcgcct atagctatgg tttctcgcaa tcgctttggg      420

cagtcggttg tggcggtgcg tcttctgaga cccgaaggtt ggcgattatc tgctggaggt      480

cttcgatacc gtcttcgaag aacaagacat atgttcgctg agctcggaca taggatagtc      540

ggcataggcg gataccctcg ccacgcaaat ggcgcgatcg acaccctgat cggagcctgc      600

gaagtgccac agtttattgg aaccatcccc cgttcattcc gccctggaat ttcacttcga      660

cggcattcta gatcctcgcc gttgtcttag agagccatct ttcgtcggcg cacccttaag      720

tgcatggaaa gccgttttcg cttcaaatga aatcgaaaag aagaaaacaa aaatcctaga      780

gtaaccgacc ctcccgataa tcgtgaacat cagatgacag catttcttcc gaccgaagtg      840

gctgtgttgg ttatgagctt ggggagatgg ggaggtacca tgagcggctc caagaagcgc      900

cgcatcaagc aagattcaaa gctggagaag ttcaccaact gctactcgct gagcaagacg      960

ctgcggttca aggccatccc cgtgggcaag acccaggaga acatcgacaa caagcgcctc     1020

ctggtcgagg acgagaagcg cgccgaggac tacaagggcg tcaagaagct cctggaccgg     1080

tattacctca gcttcatcaa cgacgtgctg cactcgatca agctcaagaa cctgaacaac     1140

tacatcagcc tgttccgcaa gaaaacgcgc accgagaagg agaacaaaga gctggagaac     1200

ctggagatca acctgcggaa ggagattgcg aaagctttca agggcaacga gggctacaag     1260

tcgctcttca agaaagacat aatcgagacc atcctgccgg agttcctgga cgacaaggac     1320

gagatcgcgc tcgtcaactc gttcaacggg ttcactacgg ccttcacggg tttcttcgat     1380

aaccgggaga atatgtttag cgaggaggcc aagtccacct ccattgcgtt ccgctgcatc     1440

aacgagaacc tgacccgcta catcagcaac atggacatct tcgagaaggt ggacgccatc     1500

ttcgacaagc acgaggtcca ggagatcaag gagaagattc tgaactcgga ctacgacgtg     1560

gaagacttct tcgagggcga gtttttcaac ttcgtcctga cccaggaggg gatcgacgtt     1620

tataacgcca tcatcggcgg gttcgtcacg gagtcgggcg aaaagatcaa gggcctgaac     1680

gagtatatta acctgtacaa ccagaagaca aagcagaagc tgccgaagtt caagccgctg     1740

tacaagcaag tcctgtccga ccgcgagtcg ctgtcgttct acggcgaagg ctacacctcg     1800

gacgaggagg tgctggaggt gttccgcaac accctgaaca agaatagcga aatttttagc     1860

tccattaaga agctcgagaa gctgttcaag aacttcgacg agtacagcag cgccgggatc     1920

ttcgtcaaga acggccccgc gatcagcacc atctcgaagg acatcttcgg cgagtggaac     1980

gtcatccggg acaagtggaa cgccgagtac gacgacattc accttaaaaa gaaggctgtt     2040

gtgacggaga agtacgagga cgaccggcgc aagtcgttca aaaagatcgg ctccttctcc     2100

ctggagcagc tccaggagta cgccgacgcc gacctctcgg tcgtcgagaa gctcaaggag     2160

atcatcattc agaaggtgga cgaaatttac aaagtgtacg gctccagcga gaagctgttc     2220

gacgccgact tcgtgctgga aaagtcgctc aagaaaaacg acgccgtggt ggccatcatg     2280

aaggacttgc tggacagcgt gaagtcgttc gagaactaca ttaaggcgtt ctttggcgag     2340

ggcaaggaga ccaaccgcga cgagtcgttc tacggcgact tcgtgctcgc gtacgacatc     2400

ctgctcaagg tggatcacat ctacgacgcg atccgcaact acgtcacgca gaagccgtac     2460

tcgaaggaca agttcaagct gtacttccag aacccgcagt tcatgggcgg gtgggacaag     2520

gacaaggaaa cggactaccg cgcgaccatc ctgcggtacg gcagcaagta ttatctggcg     2580

atcatggaca aaaaatatgc caagtgcctc cagaaaatcg acaaggacga cgtgaacggc     2640

aactacgaga agattaatta caagctgctc cccggcccca acaagatgct cccgaaggtg     2700

ttctttagca agaagtggat ggcctactac aacccgagcg aggacatcca gaagatctat     2760

aagaatggca ccttcaagaa gggagacatg tttaacctca acgactgcca caagctgatt     2820

gacttcttca aggactcgat ctcgcgctac ccgaagtggt cgaacgccta cgacttcaac     2880

ttcagcgaaa cggagaaata caaagacatc gcgggcttct accgcgaggt cgaggagcaa     2940

ggctacaagg tcagcttcga gtccgccagc aagaaggagg tggacaagct ggtggaggag     3000

ggcaagctct acatgtttca gatctacaac aaggatttta gcgacaagtc gcacggcacg     3060

ccgaacctgc acacgatgta cttcaagctg ctgttcgacg agaacaacca cggccagatc     3120

cggctgtcgg gcggtgcgga gctgttcatg cgccgggcgt cgctcaagaa ggaagagctg     3180

gtcgtccacc cggccaacag ccccatcgcc aacaagaacc ccgacaaccc caagaaaacg     3240

acgacactca gctatgatgt ctataaagac aagcgcttct cggaggacca gtacgagctg     3300

cacatcccca tcgccatcaa caagtgcccc aagaacatct tcaagatcaa cacggaggtc     3360

cgcgtgctcc tcaagcacga cgacaacccg tacgtcatcg gcatcgaccg gggcgagcgc     3420

aacctgctgt acatcgtcgt cgtcgatggc aagggcaaca tcgtggagca gtattccctg     3480

aacgagatca tcaacaactt caacggcatc cgcatcaaga ccgactacca ctccctcctc     3540

gacaagaagg agaaagagcg cttcgaggcc cgccagaact ggacctccat cgagaacatc     3600

aaggagctta aggcgggcta catctcccaa gtcgtccaca agatctgcga gctggtcgag     3660

aagtacgacg cggtgatcgc cctggaagac ctgaactccg gcttcaagaa ctcccgcgta     3720

aaggtggaga agcaagtgta ccagaagttc gagaagatgc tgatcgacaa gctgaactac     3780

atggtggaca agaaatcgaa cccgtgcgcg accggcggcg cgctcaaggg ctaccagatc     3840

acgaacaagt tcgagtcgtt caagtccatg agcacgcaga acggctttat cttctacatc     3900

ccggcctggc tgacgtcgaa gatcgacccc tcgaccggct tcgtgaacct gctcaagacc     3960

aagtatacta gcattgccga ctccaagaaa ttcatctcgt ccttcgaccg catcatgtac     4020

gtcccggagg aggacctttt tgagttcgcc ctcgactaca agaacttcag ccgcaccgac     4080

gccgactaca tcaagaagtg gaagctgtac tcgtacggga accgcatccg tatttttcgc     4140

aacccgaaga aaaataatgt cttcgactgg gaggaggtgt gcctgaccag cgcctacaag     4200

gagctgttca acaagtacgg catcaactac caacagggcg acatccgggc ccttctctgc     4260

gagcagagcg acaaggcgtt ctactcgtcg ttcatggccc tgatgagcct gatgctccag     4320

atgaggaaca gcatcaccgg ccgcaccgac gtggacttcc tcatcagccc cgtcaagaac     4380

tcggacggca tattttatga ctcgcggaac tacgaggccc aggagaacgc catcctgccc     4440

aagaacgccg acgccaacgg cgcgtacaac atcgcccgca aggtgctctg ggccatcggc     4500

cagttcaaga aggcggaaga cgagaagctg gacaaggtga agatcgccat ctccaacaag     4560

gagtggctgg agtacgcgca gacgtccgtc aagcacggct ccaagaaacg gcggatcaaa     4620

caagattccg gtggaagttc cggaggttca agcgggtctg aaacgccggg caccagcgag     4680

tcggcgaccc cggaaagcag cggtggttct tccggcggta gcatgcccga tcgagctcaa     4740

gttatcattc gcattgtgcc gggaggtggc accaagaccc ttcaacaaat tatcaatcag     4800

ttggagtatc tatcccggaa gggcaggctg gagctgcagc gttcagcccg acatctcgat     4860

attcccctgc caccggatca aatccacgaa cttgcccgaa gctgggttca agagactgga     4920

acttatgacg aaagtcagcc agacgaggaa aggcaacagg agttgaccac ccatattatt     4980

gtaagcttcc ccgccggtac aagccaggta gcggcttatg cggcgagccg ggagtgggca     5040

gccgagatgt ttgggtcagg cgcagggggg ggccgataca actatcttac ggccttccac     5100

atcgatcgcg accacccaca tctgcatgtc gtcgtcaatc ggcgcgaact tttaggacac     5160

ggctggctga agatatctcg gcgccatccc caactgaatt acgacgccct gcgcataaag     5220

atggccgaga tttcacttcg tcatggcatt gccctcgatg cgagccgacg agcagaacgt     5280

ggcatcaccg agcggccgat cacttatgcc caatatcggc gccttgagcg ggagcaggct     5340

cgccaaatcc gtttcgaaga cgcggatttg gaacagtcgt cgccgcaagg agatcatcca     5400

gaattcagcc aacctttcga tacatcccca tttgaagcat ccgcgggcgg accggaggac     5460

atgcctcggc ccaacaatcg gcagaatgag tcgcaagttc atctccagga gccagctggt     5520

gtcagcaacg aagccggtgt ccttgtgcgg gttgcattgg aaacggagcg ccttgctcaa     5580

ccattcgttt ccgaaaccat tctcgcggac gacataggga gcggctcttc gcgtgttgcc     5640

gagggccgtg tggagagcgc aaaccgcact cccgatattc ctcgcgcagc aactgaagct     5700

gccacgcaca cgacacacga ccggcagcgg cgtgcaaagc gtcctcatga tgacgacgga     5760

gggccgagtg gagcaaaacg tgtgacattg gaaggcatcg cggttgggcc ccaggcgaac     5820

gccggcgaac aggatggcag tagtggcccc ttagtacggc aagctggaac gtcacggcca     5880

tctccaccga cggccacgac gcgggccagc accgcaaccg attcattgtc tgctacagcc     5940

cacctccagc aacggagagg tgtcctttca aagcgtccgc gtgaagatga tgatggagaa     6000

ccgagtgaac gcaaacgcga gagagatgag cgcagcaagg acgggcgtgg gggaaatagg     6060

agatagtcta gaccaggcat caaataaaac gaaaggctca gtcgaaagac tgggcctttc     6120

gttttatctg ttgtttgtcg gtgaacgctc tctactagag tcacactggc tcaccttcgg     6180

gtgggccttt ctgcgtttat agtacgatat cccaatggcg cgccgagctt ggctcgagca     6240

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     6300

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     6360

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     6420

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctgttccgc ttcctcgctc     6480

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     6540

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     6600

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     6660

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     6720

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     6780

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     6840

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     6900

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     6960

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     7020

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     7080

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     7140

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     7200

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     7260

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     7320

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     7380

tatgagtaaa cttggtctga cagttagaaa aactcatcga gcatcaaatg aaactgcaat     7440

ttattcatat caggattatc aataccatat ttttgaaaaa gccgtttctg taatgaagga     7500

gaaaactcac cgaggcagtt ccataggatg gcaagatcct ggtatcggtc tgcgattccg     7560

actcgtccaa catcaataca acctattaat ttcccctcgt caaaaataag gttatcaagt     7620

gagaaatcac catgagtgac gactgaatcc ggtgagaatg gcaaaagttt atgcatttct     7680

ttccagactt gttcaacagg ccagccatta cgctcgtcat caaaatcact cgcatcaacc     7740

aaaccgttat tcattcgtga ttgcgcctga gcgaaacgaa atacgcgatc gctgttaaaa     7800

ggacaattac aaacaggaat cgaatgcaac cggcgcagga acactgccag cgcatcaaca     7860

atattttcac ctgaatcagg atattcttct aatacctgga atgctgtttt cccagggatc     7920

gcagtggtga gtaaccatgc atcatcagga gtacggataa aatgcttgat ggtcggaaga     7980

ggcataaatt ccgtcagcca gtttagtctg accatctcat ctgtaacatc attggcaacg     8040

ctacctttgc catgtttcag aaacaactct ggcgcatcgg gcttcccata caatcgatag     8100

attgtcgcac ctgattgccc gacattatcg cgagcccatt tatacccata taaatcagca     8160

tccatgttgg aatttaatcg cggcctagag caagacgttt cccgttgaat atggctcata     8220

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     8280

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     8340

gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt     8400

atcacgaggc ccttttgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg     8460

cagctcccgg agactgtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt     8520

cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag     8580

cagattgtac tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga     8640

aaataccgca tcaggcgcca ttcgccattc aggctgcgca actgttggga agggcgatcg     8700

gtgcgggcct cttcgctatt acgccagctg gcgaaagggg gatgtgctgc aaggcgatta     8760

agttgggtaa cgccagggtt ttcccagtca cgacgttgta aaacgacggc cagtgaattg     8820

acgcgttgcg gctgcatgaa atcctggccg gtttgtctga tgccaagctg gcggcctggc     8880

cggccagctt ggccgctgaa gaaaccgagc gccgccgtct aaaaaggtga tgtgtatttg     8940

agtaaaacag cttgcgtcat gcggtcgctg cgtatatgat gcgatgagta aataaacaaa     9000

tacgcaaggg gaacgcatga aggttatcgc tgtacttaac cagaaaggcg ggtcaggcaa     9060

gacgaccatc gcaacccatc tagcccgcgc cctgcaactc gccggggccg atgttctgtt     9120

agtcgattcc gatccccagg gcagtgcccg cgattgggcg gccgtgcggg aagatcaacc     9180

gctaaccgtt gtcggcatcg accgcccgac gattgaccgc gacgtgaagg ccatcggccg     9240

gcgcgacttc gtagtgatcg acggagcgcc ccaggcggcg gacttggctg tgtccgcgat     9300

caaggcagcc gacttcgtgc tgattccggt gcagccaagc ccttacgaca tatgggccac     9360

cgccgacctg gtggagctgg ttaagcagcg cattgaggtc acggatggaa ggctacaagc     9420

ggcctttgtc gtgtcgcggg cgatcaaagg cacgcgcatc ggcggtgagg ttgccgaggc     9480

gctggccggg tacgagctgc ccattcttga gtcccgtatc acgcagcgcg tgagctaccc     9540

aggcactgcc gccgccggca caaccgttct tgaatcagaa cccgagggcg acgctgcccg     9600

cgaggtccag gcgctggccg ctgaaattaa atcaaaactc atttgagtta atgaggtaaa     9660

gagaaaatga gcaaaagcac aaacacgcta agtgccggcc gtccgagcgc acgcagcagc     9720

aaggctgcaa cgttggccag cctggcagac acgccagcca tgaagcgggt caactttcag     9780

ttgccggcgg aggatcacac caagctgaag atgtacgcgg tacgccaagg caagaccatt     9840

accgagctgc tatctgaata catcgcgcag ctaccagagt aaatgagcaa atgaataaat     9900

gagtagatga attttagcgg ctaaaggagg cggcatggaa aatcaagaac aaccaggcac     9960

cgacgccgtg gaatgcccca tgtgtggagg aacgggcggt tggccaggcg taagcggctg    10020

ggttgtctgc cggccctgca atggcactgg aacccccaag cccgaggaat cggcgtgagc    10080

ggtcgcaaac catccggccc ggtacaaatc ggcgcggcgc tgggtgatga cctggtggag    10140

aagttgaagg ccgcgcaggc cgcccagcgg caacgcatcg aggcagaagc acgccccggt    10200

gaatcgtggc aagcggccgc tgatcgaatc cgcaaagaat cccggcaacc gccggcagcc    10260

ggtgcgccgt cgattaggaa gccgcccaag ggcgacgagc aaccagattt tttcgttccg    10320

atgctctatg acgtgggcac ccgcgatagt cgcagcatca tggacgtggc cgttttccgt    10380

ctgtcgaagc gtgaccgacg agctggcgag gtgatccgct acgagcttcc agacgggcac    10440

gtagaggttt ccgcagggcc ggccggcatg gccagtgtgt gggattacga cctggtactg    10500

atggcggttt cccatctaac cgaatccatg aaccgatacc gggaagggaa gggagacaag    10560

cccggccgcg tgttccgtcc acacgttgcg gacgtactca agttctgccg gcgagccgat    10620

ggcggaaagc agaaagacga cctggtagaa acctgcattc ggttaaacac cacgcacgtt    10680

gccatgcagc gtacgaagaa ggccaagaac ggccgcctgg tgacggtatc cgagggtgaa    10740

gccttgatta gccgctacaa gatcgtaaag agcgaaaccg ggcggccgga gtacatcgag    10800

atcgagctag ctgattggat gtaccgcgag atcacagaag gcaagaaccc ggacgtgctg    10860

acggttcacc ccgattactt tttgatcgat cccggcatcg gccgttttct ctaccgcctg    10920

gcacgccgcg ccgcaggcaa ggcagaagcc agatggttgt tcaagacgat ctacgaacgc    10980

agtggcagcg ccggagagtt caagaagttc tgtttcaccg tgcgcaagct gatcgggtca    11040

aatgacctgc cggagtacga tttgaaggag gaggcggggc aggctggccc gatcctagtc    11100

atgcgctacc gcaacctgat cgagggcgaa gcatccgccg gttcctaatg tacggagcag    11160

atgctagggc aaattgccct agcaggggaa aaaggtcgaa aaggtctctt tcctgtggat    11220

agcacgtaca ttgggaaccc aaagccgtac attgggaacc ggaacccgta cattgggaac    11280

ccaaagccgt acattgggaa ccggtcacac atgtaagtga ctgatataaa agagaaaaaa    11340

ggcgattttt ccgcctaaaa ctctttaaaa cttattaaaa ctcttaaaac ccgcctggcc    11400

tgtgcatatg ctagtcatgc cccgcgccca ccggaaggag ctgactgggt tgaaggctct    11460

caagggcatc ggtcgagatc c                                              11481


<210>  145
<211>  12796
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3901 Full Plasmid Sequence

<400>  145
cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccgaga gcgttcaccg       60

acaaacaaca gataaaacga aaggcccagt ctttcgactg agcctttcgt tttatttgat      120

gcctggttac ctcgaaagcc cgctgcgcga gcggtcacgc gatgaggcat ccagctccgc      180

tcgggtgcgg ttatagacct cattgatatt tttctcgaag gattcgtttg tcgtcagaag      240

gcccactgcg ttagggccgc ctctggcgag gctggccgaa gagccaccac tgctgccgcc      300

cgaatcctgt ttgatccgac gcttcttgct accagcagaa taaatgccgg agttcgcggc      360

aatagcggac gggatcggat ttccatcctt gaggaggccc tgcatcgcct tgacgatcaa      420

ttcgcagtcg gagttcgttg cgaatatcgg gatggtgagt tccatgttca ggtagctgcg      480

ccaggccgcc accggcagtt caacgccgcc cacggtctgc gtcgcaactt tgggaacctc      540

gaccttgatg gtgtacttcc gcttctgggc cgatgactgg cggacggagc aggtcacttt      600

atacgcttgg gaccgcgagt tgctggagat ccattccgcc actccattgg caaaattcga      660

gggggctacg gtgacatcac ccgtaccgcc gttgtcgacc aggacgaatt gagtgaaatt      720

gctggcgtcc tgcttgatgc ggcgcttctt ggacccgctc atggtacctc cccatctccc      780

caagctcata accaacacag ccacttcggt cggaagaaat gctgtcatct gatgttcacg      840

attatcggga gggtcggtta ctctaggatt tttgttttct tcttttcgat ttcatttgaa      900

gcgaaaacgg ctttccatgc acttaagggt gcgccgacga aagatggctc tctaagacaa      960

cggcgaggat ctagaatgcc gtcgaagtga aattccaggg cggaatgaac gggggatggt     1020

tccaataaac tgtggcactt cgcaggctcc gatcagggtg tcgatcgcgc catttgcgtg     1080

gcgagggtat ccgcctatgc cgactatcct atgtccgagc tcagcgaaca tatgtcttgt     1140

tcttcgaaga cggtatcgaa gacctccagc agataatcgc caaccttcgg gtctcagaag     1200

acgcaccgcc acaaccgact gcccaaagcg attgcgagaa accatagcta taggcgcgcc     1260

gaacagacgt gctgattacc ctggtcgagt ctccttaatt aacaaaaaac ccctcaagac     1320

ccgtttagag gccccaaggg gttatgctag ttattgctca gcggaatcta cacttagtag     1380

aaattaggga acacgagcga catgggtgat cctcatgtcg ctcgtggcac atgggtgatc     1440

ctcatgtgct ccctatccac atgtgttttt agtaaaatct acacttagta gaaattattt     1500

aatctttgaa acgctagcat tatacctagg actgagctag ctgtcaacaa ttggggatga     1560

gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa     1620

tctaaagtat atatgtgtaa cattggtcta gtgattggat ccggagactc gaccagggta     1680

atcagcacgt ctgttcggcg cgcctatagc tatggtttct cgcaatcgct ttgggcagtc     1740

ggttgtggcg gtgcgtcttc tgagacccga aggttggcga ttatctgctg gaggtcttcg     1800

ataccgtctt cgaagaacaa gacatatgtt cgctgagctc ggacatagga tagtcggcat     1860

aggcggatac cctcgccacg caaatggcgc gatcgacacc ctgatcggag cctgcgaagt     1920

gccacagttt attggaacca tcccccgttc attccgccct ggaatttcac ttcgacggca     1980

ttctagatcc tcgccgttgt cttagagagc catctttcgt cggcgcaccc ttaagtgcat     2040

ggaaagccgt tttcgcttca aatgaaatcg aaaagaagaa aacaaaaatc ctagagtaac     2100

cgaccctccc gataatcgtg aacatcagat gacagcattt cttccgaccg aagtggctgt     2160

gttggttatg agcttgggga gatggggagg taccatgagc ggctccaaga agcgccgcat     2220

caagcaagat tcaaagctgg agaagttcac caactgctac tcgctgagca agacgctgcg     2280

gttcaaggcc atccccgtgg gcaagaccca ggagaacatc gacaacaagc gcctcctggt     2340

cgaggacgag aagcgcgccg aggactacaa gggcgtcaag aagctcctgg accggtatta     2400

cctcagcttc atcaacgacg tgctgcactc gatcaagctc aagaacctga acaactacat     2460

cagcctgttc cgcaagaaaa cgcgcaccga gaaggagaac aaagagctgg agaacctgga     2520

gatcaacctg cggaaggaga ttgcgaaagc tttcaagggc aacgagggct acaagtcgct     2580

cttcaagaaa gacataatcg agaccatcct gccggagttc ctggacgaca aggacgagat     2640

cgcgctcgtc aactcgttca acgggttcac tacggccttc acgggtttct tcgataaccg     2700

ggagaatatg tttagcgagg aggccaagtc cacctccatt gcgttccgct gcatcaacga     2760

gaacctgacc cgctacatca gcaacatgga catcttcgag aaggtggacg ccatcttcga     2820

caagcacgag gtccaggaga tcaaggagaa gattctgaac tcggactacg acgtggaaga     2880

cttcttcgag ggcgagtttt tcaacttcgt cctgacccag gaggggatcg acgtttataa     2940

cgccatcatc ggcgggttcg tcacggagtc gggcgaaaag atcaagggcc tgaacgagta     3000

tattaacctg tacaaccaga agacaaagca gaagctgccg aagttcaagc cgctgtacaa     3060

gcaagtcctg tccgaccgcg agtcgctgtc gttctacggc gaaggctaca cctcggacga     3120

ggaggtgctg gaggtgttcc gcaacaccct gaacaagaat agcgaaattt ttagctccat     3180

taagaagctc gagaagctgt tcaagaactt cgacgagtac agcagcgccg ggatcttcgt     3240

caagaacggc cccgcgatca gcaccatctc gaaggacatc ttcggcgagt ggaacgtcat     3300

ccgggacaag tggaacgccg agtacgacga cattcacctt aaaaagaagg ctgttgtgac     3360

ggagaagtac gaggacgacc ggcgcaagtc gttcaaaaag atcggctcct tctccctgga     3420

gcagctccag gagtacgccg acgccgacct ctcggtcgtc gagaagctca aggagatcat     3480

cattcagaag gtggacgaaa tttacaaagt gtacggctcc agcgagaagc tgttcgacgc     3540

cgacttcgtg ctggaaaagt cgctcaagaa aaacgacgcc gtggtggcca tcatgaagga     3600

cttgctggac agcgtgaagt cgttcgagaa ctacattaag gcgttctttg gcgagggcaa     3660

ggagaccaac cgcgacgagt cgttctacgg cgacttcgtg ctcgcgtacg acatcctgct     3720

caaggtggat cacatctacg acgcgatccg caactacgtc acgcagaagc cgtactcgaa     3780

ggacaagttc aagctgtact tccagaaccc gcagttcatg ggcgggtggg acaaggacaa     3840

ggaaacggac taccgcgcga ccatcctgcg gtacggcagc aagtattatc tggcgatcat     3900

ggacaaaaaa tatgccaagt gcctccagaa aatcgacaag gacgacgtga acggcaacta     3960

cgagaagatt aattacaagc tgctccccgg ccccaacaag atgctcccga aggtgttctt     4020

tagcaagaag tggatggcct actacaaccc gagcgaggac atccagaaga tctataagaa     4080

tggcaccttc aagaagggag acatgtttaa cctcaacgac tgccacaagc tgattgactt     4140

cttcaaggac tcgatctcgc gctacccgaa gtggtcgaac gcctacgact tcaacttcag     4200

cgaaacggag aaatacaaag acatcgcggg cttctaccgc gaggtcgagg agcaaggcta     4260

caaggtcagc ttcgagtccg ccagcaagaa ggaggtggac aagctggtgg aggagggcaa     4320

gctctacatg tttcagatct acaacaagga ttttagcgac aagtcgcacg gcacgccgaa     4380

cctgcacacg atgtacttca agctgctgtt cgacgagaac aaccacggcc agatccggct     4440

gtcgggcggt gcggagctgt tcatgcgccg ggcgtcgctc aagaaggaag agctggtcgt     4500

ccacccggcc aacagcccca tcgccaacaa gaaccccgac aaccccaaga aaacgacgac     4560

actcagctat gatgtctata aagacaagcg cttctcggag gaccagtacg agctgcacat     4620

ccccatcgcc atcaacaagt gccccaagaa catcttcaag atcaacacgg aggtccgcgt     4680

gctcctcaag cacgacgaca acccgtacgt catcggcatc gaccggggcg agcgcaacct     4740

gctgtacatc gtcgtcgtcg atggcaaggg caacatcgtg gagcagtatt ccctgaacga     4800

gatcatcaac aacttcaacg gcatccgcat caagaccgac taccactccc tcctcgacaa     4860

gaaggagaaa gagcgcttcg aggcccgcca gaactggacc tccatcgaga acatcaagga     4920

gcttaaggcg ggctacatct cccaagtcgt ccacaagatc tgcgagctgg tcgagaagta     4980

cgacgcggtg atcgccctgg aagacctgaa ctccggcttc aagaactccc gcgtaaaggt     5040

ggagaagcaa gtgtaccaga agttcgagaa gatgctgatc gacaagctga actacatggt     5100

ggacaagaaa tcgaacccgt gcgcgaccgg cggcgcgctc aagggctacc agatcacgaa     5160

caagttcgag tcgttcaagt ccatgagcac gcagaacggc tttatcttct acatcccggc     5220

ctggctgacg tcgaagatcg acccctcgac cggcttcgtg aacctgctca agaccaagta     5280

tactagcatt gccgactcca agaaattcat ctcgtccttc gaccgcatca tgtacgtccc     5340

ggaggaggac ctttttgagt tcgccctcga ctacaagaac ttcagccgca ccgacgccga     5400

ctacatcaag aagtggaagc tgtactcgta cgggaaccgc atccgtattt ttcgcaaccc     5460

gaagaaaaat aatgtcttcg actgggagga ggtgtgcctg accagcgcct acaaggagct     5520

gttcaacaag tacggcatca actaccaaca gggcgacatc cgggcccttc tctgcgagca     5580

gagcgacaag gcgttctact cgtcgttcat ggccctgatg agcctgatgc tccagatgag     5640

gaacagcatc accggccgca ccgacgtgga cttcctcatc agccccgtca agaactcgga     5700

cggcatattt tatgactcgc ggaactacga ggcccaggag aacgccatcc tgcccaagaa     5760

cgccgacgcc aacggcgcgt acaacatcgc ccgcaaggtg ctctgggcca tcggccagtt     5820

caagaaggcg gaagacgaga agctggacaa ggtgaagatc gccatctcca acaaggagtg     5880

gctggagtac gcgcagacgt ccgtcaagca cggctccaag aaacggcgga tcaaacaaga     5940

ttccggtgga agttccggag gttcaagcgg gtctgaaacg ccgggcacca gcgagtcggc     6000

gaccccggaa agcagcggtg gttcttccgg cggtagcatg cccgatcgag ctcaagttat     6060

cattcgcatt gtgccgggag gtggcaccaa gacccttcaa caaattatca atcagttgga     6120

gtatctatcc cggaagggca ggctggagct gcagcgttca gcccgacatc tcgatattcc     6180

cctgccaccg gatcaaatcc acgaacttgc ccgaagctgg gttcaagaga ctggaactta     6240

tgacgaaagt cagccagacg aggaaaggca acaggagttg accacccata ttattgtaag     6300

cttccccgcc ggtacaagcc aggtagcggc ttatgcggcg agccgggagt gggcagccga     6360

gatgtttggg tcaggcgcag gggggggccg atacaactat cttacggcct tccacatcga     6420

tcgcgaccac ccacatctgc atgtcgtcgt caatcggcgc gaacttttag gacacggctg     6480

gctgaagata tctcggcgcc atccccaact gaattacgac gccctgcgca taaagatggc     6540

cgagatttca cttcgtcatg gcattgccct cgatgcgagc cgacgagcag aacgtggcat     6600

caccgagcgg ccgatcactt atgcccaata tcggcgcctt gagcgggagc aggctcgcca     6660

aatccgtttc gaagacgcgg atttggaaca gtcgtcgccg caaggagatc atccagaatt     6720

cagccaacct ttcgatacat ccccatttga agcatccgcg ggcggaccgg aggacatgcc     6780

tcggcccaac aatcggcaga atgagtcgca agttcatctc caggagccag ctggtgtcag     6840

caacgaagcc ggtgtccttg tgcgggttgc attggaaacg gagcgccttg ctcaaccatt     6900

cgtttccgaa accattctcg cggacgacat agggagcggc tcttcgcgtg ttgccgaggg     6960

ccgtgtggag agcgcaaacc gcactcccga tattcctcgc gcagcaactg aagctgccac     7020

gcacacgaca cacgaccggc agcggcgtgc aaagcgtcct catgatgacg acggagggcc     7080

gagtggagca aaacgtgtga cattggaagg catcgcggtt gggccccagg cgaacgccgg     7140

cgaacaggat ggcagtagtg gccccttagt acggcaagct ggaacgtcac ggccatctcc     7200

accgacggcc acgacgcggg ccagcaccgc aaccgattca ttgtctgcta cagcccacct     7260

ccagcaacgg agaggtgtcc tttcaaagcg tccgcgtgaa gatgatgatg gagaaccgag     7320

tgaacgcaaa cgcgagagag atgagcgcag caaggacggg cgtgggggaa ataggagata     7380

gtctagacca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt     7440

atctgttgtt tgtcggtgaa cgctctctac tagagtcaca ctggctcacc ttcgggtggg     7500

cctttctgcg tttatagtac gatatcccaa tggcgcgccg agcttggctc gagcatggtc     7560

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg     7620

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt     7680

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg     7740

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct cgctcactga     7800

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     7860

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     7920

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     7980

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     8040

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     8100

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     8160

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     8220

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     8280

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     8340

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     8400

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     8460

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     8520

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     8580

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     8640

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     8700

gtaaacttgg tctgacagtt agaaaaactc atcgagcatc aaatgaaact gcaatttatt     8760

catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa     8820

ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg     8880

tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa     8940

atcaccatga gtgacgactg aatccggtga gaatggcaaa agtttatgca tttctttcca     9000

gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc     9060

gttattcatt cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt taaaaggaca     9120

attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt     9180

ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccag ggatcgcagt     9240

ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat     9300

aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc     9360

tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt     9420

cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat     9480

gttggaattt aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc tcatactctt     9540

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     9600

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     9660

acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac     9720

gaggcccttt tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct     9780

cccggagact gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg     9840

cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat     9900

tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata     9960

ccgcatcagg cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg    10020

ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg    10080

ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgacgcg    10140

ttgcggctgc atgaaatcct ggccggtttg tctgatgcca agctggcggc ctggccggcc    10200

agcttggccg ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt atttgagtaa    10260

aacagcttgc gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa acaaatacgc    10320

aaggggaacg catgaaggtt atcgctgtac ttaaccagaa aggcgggtca ggcaagacga    10380

ccatcgcaac ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt ctgttagtcg    10440

attccgatcc ccagggcagt gcccgcgatt gggcggccgt gcgggaagat caaccgctaa    10500

ccgttgtcgg catcgaccgc ccgacgattg accgcgacgt gaaggccatc ggccggcgcg    10560

acttcgtagt gatcgacgga gcgccccagg cggcggactt ggctgtgtcc gcgatcaagg    10620

cagccgactt cgtgctgatt ccggtgcagc caagccctta cgacatatgg gccaccgccg    10680

acctggtgga gctggttaag cagcgcattg aggtcacgga tggaaggcta caagcggcct    10740

ttgtcgtgtc gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc gaggcgctgg    10800

ccgggtacga gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc tacccaggca    10860

ctgccgccgc cggcacaacc gttcttgaat cagaacccga gggcgacgct gcccgcgagg    10920

tccaggcgct ggccgctgaa attaaatcaa aactcatttg agttaatgag gtaaagagaa    10980

aatgagcaaa agcacaaaca cgctaagtgc cggccgtccg agcgcacgca gcagcaaggc    11040

tgcaacgttg gccagcctgg cagacacgcc agccatgaag cgggtcaact ttcagttgcc    11100

ggcggaggat cacaccaagc tgaagatgta cgcggtacgc caaggcaaga ccattaccga    11160

gctgctatct gaatacatcg cgcagctacc agagtaaatg agcaaatgaa taaatgagta    11220

gatgaatttt agcggctaaa ggaggcggca tggaaaatca agaacaacca ggcaccgacg    11280

ccgtggaatg ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc ggctgggttg    11340

tctgccggcc ctgcaatggc actggaaccc ccaagcccga ggaatcggcg tgagcggtcg    11400

caaaccatcc ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg tggagaagtt    11460

gaaggccgcg caggccgccc agcggcaacg catcgaggca gaagcacgcc ccggtgaatc    11520

gtggcaagcg gccgctgatc gaatccgcaa agaatcccgg caaccgccgg cagccggtgc    11580

gccgtcgatt aggaagccgc ccaagggcga cgagcaacca gattttttcg ttccgatgct    11640

ctatgacgtg ggcacccgcg atagtcgcag catcatggac gtggccgttt tccgtctgtc    11700

gaagcgtgac cgacgagctg gcgaggtgat ccgctacgag cttccagacg ggcacgtaga    11760

ggtttccgca gggccggccg gcatggccag tgtgtgggat tacgacctgg tactgatggc    11820

ggtttcccat ctaaccgaat ccatgaaccg ataccgggaa gggaagggag acaagcccgg    11880

ccgcgtgttc cgtccacacg ttgcggacgt actcaagttc tgccggcgag ccgatggcgg    11940

aaagcagaaa gacgacctgg tagaaacctg cattcggtta aacaccacgc acgttgccat    12000

gcagcgtacg aagaaggcca agaacggccg cctggtgacg gtatccgagg gtgaagcctt    12060

gattagccgc tacaagatcg taaagagcga aaccgggcgg ccggagtaca tcgagatcga    12120

gctagctgat tggatgtacc gcgagatcac agaaggcaag aacccggacg tgctgacggt    12180

tcaccccgat tactttttga tcgatcccgg catcggccgt tttctctacc gcctggcacg    12240

ccgcgccgca ggcaaggcag aagccagatg gttgttcaag acgatctacg aacgcagtgg    12300

cagcgccgga gagttcaaga agttctgttt caccgtgcgc aagctgatcg ggtcaaatga    12360

cctgccggag tacgatttga aggaggaggc ggggcaggct ggcccgatcc tagtcatgcg    12420

ctaccgcaac ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg agcagatgct    12480

agggcaaatt gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg tggatagcac    12540

gtacattggg aacccaaagc cgtacattgg gaaccggaac ccgtacattg ggaacccaaa    12600

gccgtacatt gggaaccggt cacacatgta agtgactgat ataaaagaga aaaaaggcga    12660

tttttccgcc taaaactctt taaaacttat taaaactctt aaaacccgcc tggcctgtgc    12720

atatgctagt catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg    12780

gcatcggtcg agatcc                                                    12796


<210>  146
<211>  12796
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3902 Full Plasmid Sequence

<400>  146
cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccgaga gcgttcaccg       60

acaaacaaca gataaaacga aaggcccagt ctttcgactg agcctttcgt tttatttgat      120

gcctggttac ctcgaaagcc cgctgcgcga gcggtcacgc gatgaggcat ccagctccgc      180

tcgggtgcgg ttatagacct cattgatatt tttctcgaag gattcgtttg tcgtcagaag      240

gcccactgcg ttagggccgc ctctggcgag gctggccgaa gagccaccac tgctgccgcc      300

cgaatcctgt ttgatccgac gcttcttgct accagcagaa taaatgccgg agttcgcggc      360

aatagcggac gggatcggat ttccatcctt gaggaggccc tgcatcgcct tgacgatcaa      420

ttcgcagtcg gagttcgttg cgaatatcgg gatggtgagt tccatgttca ggtagctgcg      480

ccaggccgcc accggcagtt caacgccgcc cacggtctgc gtcgcaactt tgggaacctc      540

gaccttgatg gtgtacttcc gcttctgggc cgatgactgg cggacggagc aggtcacttt      600

atacgcttgg gaccgcgagt tgctggagat ccattccgcc actccattgg caaaattcga      660

gggggctacg gtgacatcac ccgtaccgcc gttgtcgacc aggacgaatt gagtgaaatt      720

gctggcgtcc tgcttgatgc ggcgcttctt ggacccgctc atggtacctc cccatctccc      780

caagctcata accaacacag ccacttcggt cggaagaaat gctgtcatct gatgttcacg      840

attatcggga gggtcggtta ctctaggatt tttgttttct tcttttcgat ttcatttgaa      900

gcgaaaacgg ctttccatgc acttaagggt gcgccgacga aagatggctc tctaagacaa      960

cggcgaggat ctagaatgcc gtcgaagtga aattccaggg cggaatgaac gggggatggt     1020

tccaataaac tgtggcactt cgcaggctcc gatcagggtg tcgatcgcgc catttgcgtg     1080

gcgagggtat ccgcctatgc cgactatcct atgtccgagc tcagcgaaca tatgtcttgt     1140

tcttcgaaga cggtatcgaa gacctccagc agataatcgc caaccttcgg gtctcagaag     1200

acgcaccgcc acaaccgact gcccaaagcg attgcgagaa accatagcta taggcgcgcc     1260

gaacagacgt gctgattacc ctggtcgagt ctccttaatt aacaaaaaac ccctcaagac     1320

ccgtttagag gccccaaggg gttatgctag ttattgctca gcggaatcta cacttagtag     1380

aaattaggga acacgagcga catgggtgat cctcatgtcg ctcgtggcac atgggtgatc     1440

ctcatgtgct ccccatggag ggcacagtta agccgcatct acacttagta gaaattattt     1500

aatctttgaa acgctagcat tatacctagg actgagctag ctgtcaacaa ttggggatga     1560

gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa     1620

tctaaagtat atatgtgtaa cattggtcta gtgattggat ccggagactc gaccagggta     1680

atcagcacgt ctgttcggcg cgcctatagc tatggtttct cgcaatcgct ttgggcagtc     1740

ggttgtggcg gtgcgtcttc tgagacccga aggttggcga ttatctgctg gaggtcttcg     1800

ataccgtctt cgaagaacaa gacatatgtt cgctgagctc ggacatagga tagtcggcat     1860

aggcggatac cctcgccacg caaatggcgc gatcgacacc ctgatcggag cctgcgaagt     1920

gccacagttt attggaacca tcccccgttc attccgccct ggaatttcac ttcgacggca     1980

ttctagatcc tcgccgttgt cttagagagc catctttcgt cggcgcaccc ttaagtgcat     2040

ggaaagccgt tttcgcttca aatgaaatcg aaaagaagaa aacaaaaatc ctagagtaac     2100

cgaccctccc gataatcgtg aacatcagat gacagcattt cttccgaccg aagtggctgt     2160

gttggttatg agcttgggga gatggggagg taccatgagc ggctccaaga agcgccgcat     2220

caagcaagat tcaaagctgg agaagttcac caactgctac tcgctgagca agacgctgcg     2280

gttcaaggcc atccccgtgg gcaagaccca ggagaacatc gacaacaagc gcctcctggt     2340

cgaggacgag aagcgcgccg aggactacaa gggcgtcaag aagctcctgg accggtatta     2400

cctcagcttc atcaacgacg tgctgcactc gatcaagctc aagaacctga acaactacat     2460

cagcctgttc cgcaagaaaa cgcgcaccga gaaggagaac aaagagctgg agaacctgga     2520

gatcaacctg cggaaggaga ttgcgaaagc tttcaagggc aacgagggct acaagtcgct     2580

cttcaagaaa gacataatcg agaccatcct gccggagttc ctggacgaca aggacgagat     2640

cgcgctcgtc aactcgttca acgggttcac tacggccttc acgggtttct tcgataaccg     2700

ggagaatatg tttagcgagg aggccaagtc cacctccatt gcgttccgct gcatcaacga     2760

gaacctgacc cgctacatca gcaacatgga catcttcgag aaggtggacg ccatcttcga     2820

caagcacgag gtccaggaga tcaaggagaa gattctgaac tcggactacg acgtggaaga     2880

cttcttcgag ggcgagtttt tcaacttcgt cctgacccag gaggggatcg acgtttataa     2940

cgccatcatc ggcgggttcg tcacggagtc gggcgaaaag atcaagggcc tgaacgagta     3000

tattaacctg tacaaccaga agacaaagca gaagctgccg aagttcaagc cgctgtacaa     3060

gcaagtcctg tccgaccgcg agtcgctgtc gttctacggc gaaggctaca cctcggacga     3120

ggaggtgctg gaggtgttcc gcaacaccct gaacaagaat agcgaaattt ttagctccat     3180

taagaagctc gagaagctgt tcaagaactt cgacgagtac agcagcgccg ggatcttcgt     3240

caagaacggc cccgcgatca gcaccatctc gaaggacatc ttcggcgagt ggaacgtcat     3300

ccgggacaag tggaacgccg agtacgacga cattcacctt aaaaagaagg ctgttgtgac     3360

ggagaagtac gaggacgacc ggcgcaagtc gttcaaaaag atcggctcct tctccctgga     3420

gcagctccag gagtacgccg acgccgacct ctcggtcgtc gagaagctca aggagatcat     3480

cattcagaag gtggacgaaa tttacaaagt gtacggctcc agcgagaagc tgttcgacgc     3540

cgacttcgtg ctggaaaagt cgctcaagaa aaacgacgcc gtggtggcca tcatgaagga     3600

cttgctggac agcgtgaagt cgttcgagaa ctacattaag gcgttctttg gcgagggcaa     3660

ggagaccaac cgcgacgagt cgttctacgg cgacttcgtg ctcgcgtacg acatcctgct     3720

caaggtggat cacatctacg acgcgatccg caactacgtc acgcagaagc cgtactcgaa     3780

ggacaagttc aagctgtact tccagaaccc gcagttcatg ggcgggtggg acaaggacaa     3840

ggaaacggac taccgcgcga ccatcctgcg gtacggcagc aagtattatc tggcgatcat     3900

ggacaaaaaa tatgccaagt gcctccagaa aatcgacaag gacgacgtga acggcaacta     3960

cgagaagatt aattacaagc tgctccccgg ccccaacaag atgctcccga aggtgttctt     4020

tagcaagaag tggatggcct actacaaccc gagcgaggac atccagaaga tctataagaa     4080

tggcaccttc aagaagggag acatgtttaa cctcaacgac tgccacaagc tgattgactt     4140

cttcaaggac tcgatctcgc gctacccgaa gtggtcgaac gcctacgact tcaacttcag     4200

cgaaacggag aaatacaaag acatcgcggg cttctaccgc gaggtcgagg agcaaggcta     4260

caaggtcagc ttcgagtccg ccagcaagaa ggaggtggac aagctggtgg aggagggcaa     4320

gctctacatg tttcagatct acaacaagga ttttagcgac aagtcgcacg gcacgccgaa     4380

cctgcacacg atgtacttca agctgctgtt cgacgagaac aaccacggcc agatccggct     4440

gtcgggcggt gcggagctgt tcatgcgccg ggcgtcgctc aagaaggaag agctggtcgt     4500

ccacccggcc aacagcccca tcgccaacaa gaaccccgac aaccccaaga aaacgacgac     4560

actcagctat gatgtctata aagacaagcg cttctcggag gaccagtacg agctgcacat     4620

ccccatcgcc atcaacaagt gccccaagaa catcttcaag atcaacacgg aggtccgcgt     4680

gctcctcaag cacgacgaca acccgtacgt catcggcatc gaccggggcg agcgcaacct     4740

gctgtacatc gtcgtcgtcg atggcaaggg caacatcgtg gagcagtatt ccctgaacga     4800

gatcatcaac aacttcaacg gcatccgcat caagaccgac taccactccc tcctcgacaa     4860

gaaggagaaa gagcgcttcg aggcccgcca gaactggacc tccatcgaga acatcaagga     4920

gcttaaggcg ggctacatct cccaagtcgt ccacaagatc tgcgagctgg tcgagaagta     4980

cgacgcggtg atcgccctgg aagacctgaa ctccggcttc aagaactccc gcgtaaaggt     5040

ggagaagcaa gtgtaccaga agttcgagaa gatgctgatc gacaagctga actacatggt     5100

ggacaagaaa tcgaacccgt gcgcgaccgg cggcgcgctc aagggctacc agatcacgaa     5160

caagttcgag tcgttcaagt ccatgagcac gcagaacggc tttatcttct acatcccggc     5220

ctggctgacg tcgaagatcg acccctcgac cggcttcgtg aacctgctca agaccaagta     5280

tactagcatt gccgactcca agaaattcat ctcgtccttc gaccgcatca tgtacgtccc     5340

ggaggaggac ctttttgagt tcgccctcga ctacaagaac ttcagccgca ccgacgccga     5400

ctacatcaag aagtggaagc tgtactcgta cgggaaccgc atccgtattt ttcgcaaccc     5460

gaagaaaaat aatgtcttcg actgggagga ggtgtgcctg accagcgcct acaaggagct     5520

gttcaacaag tacggcatca actaccaaca gggcgacatc cgggcccttc tctgcgagca     5580

gagcgacaag gcgttctact cgtcgttcat ggccctgatg agcctgatgc tccagatgag     5640

gaacagcatc accggccgca ccgacgtgga cttcctcatc agccccgtca agaactcgga     5700

cggcatattt tatgactcgc ggaactacga ggcccaggag aacgccatcc tgcccaagaa     5760

cgccgacgcc aacggcgcgt acaacatcgc ccgcaaggtg ctctgggcca tcggccagtt     5820

caagaaggcg gaagacgaga agctggacaa ggtgaagatc gccatctcca acaaggagtg     5880

gctggagtac gcgcagacgt ccgtcaagca cggctccaag aaacggcgga tcaaacaaga     5940

ttccggtgga agttccggag gttcaagcgg gtctgaaacg ccgggcacca gcgagtcggc     6000

gaccccggaa agcagcggtg gttcttccgg cggtagcatg cccgatcgag ctcaagttat     6060

cattcgcatt gtgccgggag gtggcaccaa gacccttcaa caaattatca atcagttgga     6120

gtatctatcc cggaagggca ggctggagct gcagcgttca gcccgacatc tcgatattcc     6180

cctgccaccg gatcaaatcc acgaacttgc ccgaagctgg gttcaagaga ctggaactta     6240

tgacgaaagt cagccagacg aggaaaggca acaggagttg accacccata ttattgtaag     6300

cttccccgcc ggtacaagcc aggtagcggc ttatgcggcg agccgggagt gggcagccga     6360

gatgtttggg tcaggcgcag gggggggccg atacaactat cttacggcct tccacatcga     6420

tcgcgaccac ccacatctgc atgtcgtcgt caatcggcgc gaacttttag gacacggctg     6480

gctgaagata tctcggcgcc atccccaact gaattacgac gccctgcgca taaagatggc     6540

cgagatttca cttcgtcatg gcattgccct cgatgcgagc cgacgagcag aacgtggcat     6600

caccgagcgg ccgatcactt atgcccaata tcggcgcctt gagcgggagc aggctcgcca     6660

aatccgtttc gaagacgcgg atttggaaca gtcgtcgccg caaggagatc atccagaatt     6720

cagccaacct ttcgatacat ccccatttga agcatccgcg ggcggaccgg aggacatgcc     6780

tcggcccaac aatcggcaga atgagtcgca agttcatctc caggagccag ctggtgtcag     6840

caacgaagcc ggtgtccttg tgcgggttgc attggaaacg gagcgccttg ctcaaccatt     6900

cgtttccgaa accattctcg cggacgacat agggagcggc tcttcgcgtg ttgccgaggg     6960

ccgtgtggag agcgcaaacc gcactcccga tattcctcgc gcagcaactg aagctgccac     7020

gcacacgaca cacgaccggc agcggcgtgc aaagcgtcct catgatgacg acggagggcc     7080

gagtggagca aaacgtgtga cattggaagg catcgcggtt gggccccagg cgaacgccgg     7140

cgaacaggat ggcagtagtg gccccttagt acggcaagct ggaacgtcac ggccatctcc     7200

accgacggcc acgacgcggg ccagcaccgc aaccgattca ttgtctgcta cagcccacct     7260

ccagcaacgg agaggtgtcc tttcaaagcg tccgcgtgaa gatgatgatg gagaaccgag     7320

tgaacgcaaa cgcgagagag atgagcgcag caaggacggg cgtgggggaa ataggagata     7380

gtctagacca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt     7440

atctgttgtt tgtcggtgaa cgctctctac tagagtcaca ctggctcacc ttcgggtggg     7500

cctttctgcg tttatagtac gatatcccaa tggcgcgccg agcttggctc gagcatggtc     7560

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg     7620

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt     7680

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg     7740

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct cgctcactga     7800

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     7860

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     7920

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     7980

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     8040

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     8100

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     8160

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     8220

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     8280

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     8340

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     8400

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     8460

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     8520

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     8580

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     8640

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     8700

gtaaacttgg tctgacagtt agaaaaactc atcgagcatc aaatgaaact gcaatttatt     8760

catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa     8820

ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg     8880

tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa     8940

atcaccatga gtgacgactg aatccggtga gaatggcaaa agtttatgca tttctttcca     9000

gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc     9060

gttattcatt cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt taaaaggaca     9120

attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt     9180

ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccag ggatcgcagt     9240

ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat     9300

aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc     9360

tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt     9420

cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat     9480

gttggaattt aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc tcatactctt     9540

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     9600

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     9660

acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac     9720

gaggcccttt tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct     9780

cccggagact gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg     9840

cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat     9900

tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata     9960

ccgcatcagg cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg    10020

ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg    10080

ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgacgcg    10140

ttgcggctgc atgaaatcct ggccggtttg tctgatgcca agctggcggc ctggccggcc    10200

agcttggccg ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt atttgagtaa    10260

aacagcttgc gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa acaaatacgc    10320

aaggggaacg catgaaggtt atcgctgtac ttaaccagaa aggcgggtca ggcaagacga    10380

ccatcgcaac ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt ctgttagtcg    10440

attccgatcc ccagggcagt gcccgcgatt gggcggccgt gcgggaagat caaccgctaa    10500

ccgttgtcgg catcgaccgc ccgacgattg accgcgacgt gaaggccatc ggccggcgcg    10560

acttcgtagt gatcgacgga gcgccccagg cggcggactt ggctgtgtcc gcgatcaagg    10620

cagccgactt cgtgctgatt ccggtgcagc caagccctta cgacatatgg gccaccgccg    10680

acctggtgga gctggttaag cagcgcattg aggtcacgga tggaaggcta caagcggcct    10740

ttgtcgtgtc gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc gaggcgctgg    10800

ccgggtacga gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc tacccaggca    10860

ctgccgccgc cggcacaacc gttcttgaat cagaacccga gggcgacgct gcccgcgagg    10920

tccaggcgct ggccgctgaa attaaatcaa aactcatttg agttaatgag gtaaagagaa    10980

aatgagcaaa agcacaaaca cgctaagtgc cggccgtccg agcgcacgca gcagcaaggc    11040

tgcaacgttg gccagcctgg cagacacgcc agccatgaag cgggtcaact ttcagttgcc    11100

ggcggaggat cacaccaagc tgaagatgta cgcggtacgc caaggcaaga ccattaccga    11160

gctgctatct gaatacatcg cgcagctacc agagtaaatg agcaaatgaa taaatgagta    11220

gatgaatttt agcggctaaa ggaggcggca tggaaaatca agaacaacca ggcaccgacg    11280

ccgtggaatg ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc ggctgggttg    11340

tctgccggcc ctgcaatggc actggaaccc ccaagcccga ggaatcggcg tgagcggtcg    11400

caaaccatcc ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg tggagaagtt    11460

gaaggccgcg caggccgccc agcggcaacg catcgaggca gaagcacgcc ccggtgaatc    11520

gtggcaagcg gccgctgatc gaatccgcaa agaatcccgg caaccgccgg cagccggtgc    11580

gccgtcgatt aggaagccgc ccaagggcga cgagcaacca gattttttcg ttccgatgct    11640

ctatgacgtg ggcacccgcg atagtcgcag catcatggac gtggccgttt tccgtctgtc    11700

gaagcgtgac cgacgagctg gcgaggtgat ccgctacgag cttccagacg ggcacgtaga    11760

ggtttccgca gggccggccg gcatggccag tgtgtgggat tacgacctgg tactgatggc    11820

ggtttcccat ctaaccgaat ccatgaaccg ataccgggaa gggaagggag acaagcccgg    11880

ccgcgtgttc cgtccacacg ttgcggacgt actcaagttc tgccggcgag ccgatggcgg    11940

aaagcagaaa gacgacctgg tagaaacctg cattcggtta aacaccacgc acgttgccat    12000

gcagcgtacg aagaaggcca agaacggccg cctggtgacg gtatccgagg gtgaagcctt    12060

gattagccgc tacaagatcg taaagagcga aaccgggcgg ccggagtaca tcgagatcga    12120

gctagctgat tggatgtacc gcgagatcac agaaggcaag aacccggacg tgctgacggt    12180

tcaccccgat tactttttga tcgatcccgg catcggccgt tttctctacc gcctggcacg    12240

ccgcgccgca ggcaaggcag aagccagatg gttgttcaag acgatctacg aacgcagtgg    12300

cagcgccgga gagttcaaga agttctgttt caccgtgcgc aagctgatcg ggtcaaatga    12360

cctgccggag tacgatttga aggaggaggc ggggcaggct ggcccgatcc tagtcatgcg    12420

ctaccgcaac ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg agcagatgct    12480

agggcaaatt gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg tggatagcac    12540

gtacattggg aacccaaagc cgtacattgg gaaccggaac ccgtacattg ggaacccaaa    12600

gccgtacatt gggaaccggt cacacatgta agtgactgat ataaaagaga aaaaaggcga    12660

tttttccgcc taaaactctt taaaacttat taaaactctt aaaacccgcc tggcctgtgc    12720

atatgctagt catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg    12780

gcatcggtcg agatcc                                                    12796


<210>  147
<211>  11110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3905 Full Plasmid Sequence

<400>  147
gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt       60

gcctaatgag tgagctaact tacattaatt gcgttgcgcc ccttaattaa caaaaaaccc      120

ctcaagaccc gtttagaggc cccaaggggt tatgctagtt attgctcagc ggaatctaca      180

cttagtagaa attatatcca catgtgtttt tagtaaaatc tacacttagt agaaattatt      240

taatctttga aacgctagca ttatacctag gactgagcta gctgtcaaca attggggatg      300

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca      360

atctaaagta tatatgtgta acattggtct agtgattgga tccttgacag ctagctcagt      420

cctaggtact gtgctagcgc tagcaaagag gagaaaggta ccatgcccga tcgagctcaa      480

gttatcattc gcattgtgcc gggaggtggc accaagaccc ttcaacaaat tatcaatcag      540

ttggagtatc tatcccggaa gggcaggctg gagctgcagc gttcagcccg acatctcgat      600

attcccctgc caccggatca aatccacgaa cttgcccgaa gctgggttca agagactgga      660

acttatgacg aaagtcagcc agacgaggaa aggcaacagg agttgaccac ccatattatt      720

gtaagcttcc ccgccggtac aagccaggta gcggcttatg cggcgagccg ggagtgggca      780

gccgagatgt ttgggtcagg cgcagggggg ggccgataca actatcttac ggccttccac      840

atcgatcgcg accacccaca tctgcatgtc gtcgtcaatc ggcgcgaact tttaggacac      900

ggctggctga agatatctcg gcgccatccc caactgaatt acgacgccct gcgcataaag      960

atggccgaga tttcacttcg tcatggcatt gccctcgatg cgagccgacg agcagaacgt     1020

ggcatcaccg agcggccgat cacttatgcc caatatcggc gccttgagcg ggagcaggct     1080

cgccaaatcc gtttcgaaga cgcggatttg gaacagtcgt cgccgcaagg agatcatcca     1140

gaattcagcc aacctttcga tacatcccca tttgaagcat ccgcgggcgg accggaggac     1200

atgcctcggc ccaacaatcg gcagaatgag tcgcaagttc atctccagga gccagctggt     1260

gtcagcaacg aagccggtgt ccttgtgcgg gttgcattgg aaacggagcg ccttgctcaa     1320

ccattcgttt ccgaaaccat tctcgcggac gacataggga gcggctcttc gcgtgttgcc     1380

gagggccgtg tggagagcgc aaaccgcact cccgatattc ctcgcgcagc aactgaagct     1440

gccacgcaca cgacacacga ccggcagcgg cgtgcaaagc gtcctcatga tgacgacgga     1500

gggccgagtg gagcaaaacg tgtgacattg gaaggcatcg cggttgggcc ccaggcgaac     1560

gccggcgaac aggatggcag tagtggcccc ttagtacggc aagctggaac gtcacggcca     1620

tctccaccga cggccacgac gcgggccagc accgcaaccg attcattgtc tgctacagcc     1680

cacctccagc aacggagagg tgtcctttca aagcgtccgc gtgaagatga tgatggagaa     1740

ccgagtgaac gcaaacgcga gagagatgag cgcagcaagg acgggcgtgg gggaaatagg     1800

agaagcggtg gctcctcggg tggcagcatg agcggctcca agaagcgccg catcaagcaa     1860

gattcaaagc tggagaagtt caccaactgc tactcgctga gcaagacgct gcggttcaag     1920

gccatccccg tgggcaagac ccaggagaac atcgacaaca agcgcctcct ggtcgaggac     1980

gagaagcgcg ccgaggacta caagggcgtc aagaagctcc tggaccggta ttacctcagc     2040

ttcatcaacg acgtgctgca ctcgatcaag ctcaagaacc tgaacaacta catcagcctg     2100

ttccgcaaga aaacgcgcac cgagaaggag aacaaagagc tggagaacct ggagatcaac     2160

ctgcggaagg agattgcgaa agctttcaag ggcaacgagg gctacaagtc gctcttcaag     2220

aaagacataa tcgagaccat cctgccggag ttcctggacg acaaggacga gatcgcgctc     2280

gtcaactcgt tcaacgggtt cactacggcc ttcacgggtt tcttcgataa ccgggagaat     2340

atgtttagcg aggaggccaa gtccacctcc attgcgttcc gctgcatcaa cgagaacctg     2400

acccgctaca tcagcaacat ggacatcttc gagaaggtgg acgccatctt cgacaagcac     2460

gaggtccagg agatcaagga gaagattctg aactcggact acgacgtgga agacttcttc     2520

gagggcgagt ttttcaactt cgtcctgacc caggagggga tcgacgttta taacgccatc     2580

atcggcgggt tcgtcacgga gtcgggcgaa aagatcaagg gcctgaacga gtatattaac     2640

ctgtacaacc agaagacaaa gcagaagctg ccgaagttca agccgctgta caagcaagtc     2700

ctgtccgacc gcgagtcgct gtcgttctac ggcgaaggct acacctcgga cgaggaggtg     2760

ctggaggtgt tccgcaacac cctgaacaag aatagcgaaa tttttagctc cattaagaag     2820

ctcgagaagc tgttcaagaa cttcgacgag tacagcagcg ccgggatctt cgtcaagaac     2880

ggccccgcga tcagcaccat ctcgaaggac atcttcggcg agtggaacgt catccgggac     2940

aagtggaacg ccgagtacga cgacattcac cttaaaaaga aggctgttgt gacggagaag     3000

tacgaggacg accggcgcaa gtcgttcaaa aagatcggct ccttctccct ggagcagctc     3060

caggagtacg ccgacgccga cctctcggtc gtcgagaagc tcaaggagat catcattcag     3120

aaggtggacg aaatttacaa agtgtacggc tccagcgaga agctgttcga cgccgacttc     3180

gtgctggaaa agtcgctcaa gaaaaacgac gccgtggtgg ccatcatgaa ggacttgctg     3240

gacagcgtga agtcgttcga gaactacatt aaggcgttct ttggcgaggg caaggagacc     3300

aaccgcgacg agtcgttcta cggcgacttc gtgctcgcgt acgacatcct gctcaaggtg     3360

gatcacatct acgacgcgat ccgcaactac gtcacgcaga agccgtactc gaaggacaag     3420

ttcaagctgt acttccagaa cccgcagttc atgggcgggt gggacaagga caaggaaacg     3480

gactaccgcg cgaccatcct gcggtacggc agcaagtatt atctggcgat catggacaaa     3540

aaatatgcca agtgcctcca gaaaatcgac aaggacgacg tgaacggcaa ctacgagaag     3600

attaattaca agctgctccc cggccccaac aagatgctcc cgaaggtgtt ctttagcaag     3660

aagtggatgg cctactacaa cccgagcgag gacatccaga agatctataa gaatggcacc     3720

ttcaagaagg gagacatgtt taacctcaac gactgccaca agctgattga cttcttcaag     3780

gactcgatct cgcgctaccc gaagtggtcg aacgcctacg acttcaactt cagcgaaacg     3840

gagaaataca aagacatcgc gggcttctac cgcgaggtcg aggagcaagg ctacaaggtc     3900

agcttcgagt ccgccagcaa gaaggaggtg gacaagctgg tggaggaggg caagctctac     3960

atgtttcaga tctacaacaa ggattttagc gacaagtcgc acggcacgcc gaacctgcac     4020

acgatgtact tcaagctgct gttcgacgag aacaaccacg gccagatccg gctgtcgggc     4080

ggtgcggagc tgttcatgcg ccgggcgtcg ctcaagaagg aagagctggt cgtccacccg     4140

gccaacagcc ccatcgccaa caagaacccc gacaacccca agaaaacgac gacactcagc     4200

tatgatgtct ataaagacaa gcgcttctcg gaggaccagt acgagctgca catccccatc     4260

gccatcaaca agtgccccaa gaacatcttc aagatcaaca cggaggtccg cgtgctcctc     4320

aagcacgacg acaacccgta cgtcatcggc atcgaccggg gcgagcgcaa cctgctgtac     4380

atcgtcgtcg tcgatggcaa gggcaacatc gtggagcagt attccctgaa cgagatcatc     4440

aacaacttca acggcatccg catcaagacc gactaccact ccctcctcga caagaaggag     4500

aaagagcgct tcgaggcccg ccagaactgg acctccatcg agaacatcaa ggagcttaag     4560

gcgggctaca tctcccaagt cgtccacaag atctgcgagc tggtcgagaa gtacgacgcg     4620

gtgatcgccc tggaagacct gaactccggc ttcaagaact cccgcgtaaa ggtggagaag     4680

caagtgtacc agaagttcga gaagatgctg atcgacaagc tgaactacat ggtggacaag     4740

aaatcgaacc cgtgcgcgac cggcggcgcg ctcaagggct accagatcac gaacaagttc     4800

gagtcgttca agtccatgag cacgcagaac ggctttatct tctacatccc ggcctggctg     4860

acgtcgaaga tcgacccctc gaccggcttc gtgaacctgc tcaagaccaa gtatactagc     4920

attgccgact ccaagaaatt catctcgtcc ttcgaccgca tcatgtacgt cccggaggag     4980

gacctttttg agttcgccct cgactacaag aacttcagcc gcaccgacgc cgactacatc     5040

aagaagtgga agctgtactc gtacgggaac cgcatccgta tttttcgcaa cccgaagaaa     5100

aataatgtct tcgactggga ggaggtgtgc ctgaccagcg cctacaagga gctgttcaac     5160

aagtacggca tcaactacca acagggcgac atccgggccc ttctctgcga gcagagcgac     5220

aaggcgttct actcgtcgtt catggccctg atgagcctga tgctccagat gaggaacagc     5280

atcaccggcc gcaccgacgt ggacttcctc atcagccccg tcaagaactc ggacggcata     5340

ttttatgact cgcggaacta cgaggcccag gagaacgcca tcctgcccaa gaacgccgac     5400

gccaacggcg cgtacaacat cgcccgcaag gtgctctggg ccatcggcca gttcaagaag     5460

gcggaagacg agaagctgga caaggtgaag atcgccatct ccaacaagga gtggctggag     5520

tacgcgcaga cgtccgtcaa gcacggctcc aagaaacggc ggatcaaaca agattccggt     5580

ggcagttccg gtggcagcag tgcgtcgtta gcaagaggcg gtccaaatgc agtgggactc     5640

ctaacgacga acgaaagctt tgagaaaaat atcaatgagg tctacaaccg tacgcgagcc     5700

gagctagacg cttcttcacg tgacagaagt cgctctggac tatcgcgata atctagacca     5760

ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt atctgttgtt     5820

tgtcggtgaa cgctctctac tagagtcaca ctggctcacc ttcgggtggg cctttctgcg     5880

tttatagtac gatatcccaa tggcgcgccg agcttggctc gagcatggtc atagctgttt     5940

cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag     6000

tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg     6060

cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg     6120

gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct cgctcactga ctcgctgcgc     6180

tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc     6240

acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg     6300

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     6360

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     6420

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     6480

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg     6540

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     6600

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     6660

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     6720

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt     6780

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     6840

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     6900

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     6960

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     7020

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     7080

tctgacagtt agaaaaactc atcgagcatc aaatgaaact gcaatttatt catatcagga     7140

ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg     7200

cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg tccaacatca     7260

atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa atcaccatga     7320

gtgacgactg aatccggtga gaatggcaaa agtttatgca tttctttcca gacttgttca     7380

acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc gttattcatt     7440

cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt taaaaggaca attacaaaca     7500

ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt ttcacctgaa     7560

tcaggatatt cttctaatac ctggaatgct gttttcccag ggatcgcagt ggtgagtaac     7620

catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat aaattccgtc     7680

agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc tttgccatgt     7740

ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt cgcacctgat     7800

tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat gttggaattt     7860

aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc tcatactctt cctttttcaa     7920

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt     7980

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc     8040

taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt     8100

tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagact     8160

gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg     8220

ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat tgtactgaga     8280

gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg     8340

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg     8400

ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca     8460

gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgacgcg ttgcggctgc     8520

atgaaatcct ggccggtttg tctgatgcca agctggcggc ctggccggcc agcttggccg     8580

ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt atttgagtaa aacagcttgc     8640

gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa acaaatacgc aaggggaacg     8700

catgaaggtt atcgctgtac ttaaccagaa aggcgggtca ggcaagacga ccatcgcaac     8760

ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt ctgttagtcg attccgatcc     8820

ccagggcagt gcccgcgatt gggcggccgt gcgggaagat caaccgctaa ccgttgtcgg     8880

catcgaccgc ccgacgattg accgcgacgt gaaggccatc ggccggcgcg acttcgtagt     8940

gatcgacgga gcgccccagg cggcggactt ggctgtgtcc gcgatcaagg cagccgactt     9000

cgtgctgatt ccggtgcagc caagccctta cgacatatgg gccaccgccg acctggtgga     9060

gctggttaag cagcgcattg aggtcacgga tggaaggcta caagcggcct ttgtcgtgtc     9120

gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc gaggcgctgg ccgggtacga     9180

gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc tacccaggca ctgccgccgc     9240

cggcacaacc gttcttgaat cagaacccga gggcgacgct gcccgcgagg tccaggcgct     9300

ggccgctgaa attaaatcaa aactcatttg agttaatgag gtaaagagaa aatgagcaaa     9360

agcacaaaca cgctaagtgc cggccgtccg agcgcacgca gcagcaaggc tgcaacgttg     9420

gccagcctgg cagacacgcc agccatgaag cgggtcaact ttcagttgcc ggcggaggat     9480

cacaccaagc tgaagatgta cgcggtacgc caaggcaaga ccattaccga gctgctatct     9540

gaatacatcg cgcagctacc agagtaaatg agcaaatgaa taaatgagta gatgaatttt     9600

agcggctaaa ggaggcggca tggaaaatca agaacaacca ggcaccgacg ccgtggaatg     9660

ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc ggctgggttg tctgccggcc     9720

ctgcaatggc actggaaccc ccaagcccga ggaatcggcg tgagcggtcg caaaccatcc     9780

ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg tggagaagtt gaaggccgcg     9840

caggccgccc agcggcaacg catcgaggca gaagcacgcc ccggtgaatc gtggcaagcg     9900

gccgctgatc gaatccgcaa agaatcccgg caaccgccgg cagccggtgc gccgtcgatt     9960

aggaagccgc ccaagggcga cgagcaacca gattttttcg ttccgatgct ctatgacgtg    10020

ggcacccgcg atagtcgcag catcatggac gtggccgttt tccgtctgtc gaagcgtgac    10080

cgacgagctg gcgaggtgat ccgctacgag cttccagacg ggcacgtaga ggtttccgca    10140

gggccggccg gcatggccag tgtgtgggat tacgacctgg tactgatggc ggtttcccat    10200

ctaaccgaat ccatgaaccg ataccgggaa gggaagggag acaagcccgg ccgcgtgttc    10260

cgtccacacg ttgcggacgt actcaagttc tgccggcgag ccgatggcgg aaagcagaaa    10320

gacgacctgg tagaaacctg cattcggtta aacaccacgc acgttgccat gcagcgtacg    10380

aagaaggcca agaacggccg cctggtgacg gtatccgagg gtgaagcctt gattagccgc    10440

tacaagatcg taaagagcga aaccgggcgg ccggagtaca tcgagatcga gctagctgat    10500

tggatgtacc gcgagatcac agaaggcaag aacccggacg tgctgacggt tcaccccgat    10560

tactttttga tcgatcccgg catcggccgt tttctctacc gcctggcacg ccgcgccgca    10620

ggcaaggcag aagccagatg gttgttcaag acgatctacg aacgcagtgg cagcgccgga    10680

gagttcaaga agttctgttt caccgtgcgc aagctgatcg ggtcaaatga cctgccggag    10740

tacgatttga aggaggaggc ggggcaggct ggcccgatcc tagtcatgcg ctaccgcaac    10800

ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg agcagatgct agggcaaatt    10860

gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg tggatagcac gtacattggg    10920

aacccaaagc cgtacattgg gaaccggaac ccgtacattg ggaacccaaa gccgtacatt    10980

gggaaccggt cacacatgta agtgactgat ataaaagaga aaaaaggcga tttttccgcc    11040

taaaactctt taaaacttat taaaactctt aaaacccgcc tggcctgtgc atatgctagt    11100

catgccccgc                                                           11110


<210>  148
<211>  11110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3906 Full Plasmid Sequence

<400>  148
gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt       60

gcctaatgag tgagctaact tacattaatt gcgttgcgcc ccttaattaa caaaaaaccc      120

ctcaagaccc gtttagaggc cccaaggggt tatgctagtt attgctcagc ggaatctaca      180

cttagtagaa attacatgga gggcacagtt aagccgcatc tacacttagt agaaattatt      240

taatctttga aacgctagca ttatacctag gactgagcta gctgtcaaca attggggatg      300

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca      360

atctaaagta tatatgtgta acattggtct agtgattgga tccttgacag ctagctcagt      420

cctaggtact gtgctagcgc tagcaaagag gagaaaggta ccatgcccga tcgagctcaa      480

gttatcattc gcattgtgcc gggaggtggc accaagaccc ttcaacaaat tatcaatcag      540

ttggagtatc tatcccggaa gggcaggctg gagctgcagc gttcagcccg acatctcgat      600

attcccctgc caccggatca aatccacgaa cttgcccgaa gctgggttca agagactgga      660

acttatgacg aaagtcagcc agacgaggaa aggcaacagg agttgaccac ccatattatt      720

gtaagcttcc ccgccggtac aagccaggta gcggcttatg cggcgagccg ggagtgggca      780

gccgagatgt ttgggtcagg cgcagggggg ggccgataca actatcttac ggccttccac      840

atcgatcgcg accacccaca tctgcatgtc gtcgtcaatc ggcgcgaact tttaggacac      900

ggctggctga agatatctcg gcgccatccc caactgaatt acgacgccct gcgcataaag      960

atggccgaga tttcacttcg tcatggcatt gccctcgatg cgagccgacg agcagaacgt     1020

ggcatcaccg agcggccgat cacttatgcc caatatcggc gccttgagcg ggagcaggct     1080

cgccaaatcc gtttcgaaga cgcggatttg gaacagtcgt cgccgcaagg agatcatcca     1140

gaattcagcc aacctttcga tacatcccca tttgaagcat ccgcgggcgg accggaggac     1200

atgcctcggc ccaacaatcg gcagaatgag tcgcaagttc atctccagga gccagctggt     1260

gtcagcaacg aagccggtgt ccttgtgcgg gttgcattgg aaacggagcg ccttgctcaa     1320

ccattcgttt ccgaaaccat tctcgcggac gacataggga gcggctcttc gcgtgttgcc     1380

gagggccgtg tggagagcgc aaaccgcact cccgatattc ctcgcgcagc aactgaagct     1440

gccacgcaca cgacacacga ccggcagcgg cgtgcaaagc gtcctcatga tgacgacgga     1500

gggccgagtg gagcaaaacg tgtgacattg gaaggcatcg cggttgggcc ccaggcgaac     1560

gccggcgaac aggatggcag tagtggcccc ttagtacggc aagctggaac gtcacggcca     1620

tctccaccga cggccacgac gcgggccagc accgcaaccg attcattgtc tgctacagcc     1680

cacctccagc aacggagagg tgtcctttca aagcgtccgc gtgaagatga tgatggagaa     1740

ccgagtgaac gcaaacgcga gagagatgag cgcagcaagg acgggcgtgg gggaaatagg     1800

agaagcggtg gctcctcggg tggcagcatg agcggctcca agaagcgccg catcaagcaa     1860

gattcaaagc tggagaagtt caccaactgc tactcgctga gcaagacgct gcggttcaag     1920

gccatccccg tgggcaagac ccaggagaac atcgacaaca agcgcctcct ggtcgaggac     1980

gagaagcgcg ccgaggacta caagggcgtc aagaagctcc tggaccggta ttacctcagc     2040

ttcatcaacg acgtgctgca ctcgatcaag ctcaagaacc tgaacaacta catcagcctg     2100

ttccgcaaga aaacgcgcac cgagaaggag aacaaagagc tggagaacct ggagatcaac     2160

ctgcggaagg agattgcgaa agctttcaag ggcaacgagg gctacaagtc gctcttcaag     2220

aaagacataa tcgagaccat cctgccggag ttcctggacg acaaggacga gatcgcgctc     2280

gtcaactcgt tcaacgggtt cactacggcc ttcacgggtt tcttcgataa ccgggagaat     2340

atgtttagcg aggaggccaa gtccacctcc attgcgttcc gctgcatcaa cgagaacctg     2400

acccgctaca tcagcaacat ggacatcttc gagaaggtgg acgccatctt cgacaagcac     2460

gaggtccagg agatcaagga gaagattctg aactcggact acgacgtgga agacttcttc     2520

gagggcgagt ttttcaactt cgtcctgacc caggagggga tcgacgttta taacgccatc     2580

atcggcgggt tcgtcacgga gtcgggcgaa aagatcaagg gcctgaacga gtatattaac     2640

ctgtacaacc agaagacaaa gcagaagctg ccgaagttca agccgctgta caagcaagtc     2700

ctgtccgacc gcgagtcgct gtcgttctac ggcgaaggct acacctcgga cgaggaggtg     2760

ctggaggtgt tccgcaacac cctgaacaag aatagcgaaa tttttagctc cattaagaag     2820

ctcgagaagc tgttcaagaa cttcgacgag tacagcagcg ccgggatctt cgtcaagaac     2880

ggccccgcga tcagcaccat ctcgaaggac atcttcggcg agtggaacgt catccgggac     2940

aagtggaacg ccgagtacga cgacattcac cttaaaaaga aggctgttgt gacggagaag     3000

tacgaggacg accggcgcaa gtcgttcaaa aagatcggct ccttctccct ggagcagctc     3060

caggagtacg ccgacgccga cctctcggtc gtcgagaagc tcaaggagat catcattcag     3120

aaggtggacg aaatttacaa agtgtacggc tccagcgaga agctgttcga cgccgacttc     3180

gtgctggaaa agtcgctcaa gaaaaacgac gccgtggtgg ccatcatgaa ggacttgctg     3240

gacagcgtga agtcgttcga gaactacatt aaggcgttct ttggcgaggg caaggagacc     3300

aaccgcgacg agtcgttcta cggcgacttc gtgctcgcgt acgacatcct gctcaaggtg     3360

gatcacatct acgacgcgat ccgcaactac gtcacgcaga agccgtactc gaaggacaag     3420

ttcaagctgt acttccagaa cccgcagttc atgggcgggt gggacaagga caaggaaacg     3480

gactaccgcg cgaccatcct gcggtacggc agcaagtatt atctggcgat catggacaaa     3540

aaatatgcca agtgcctcca gaaaatcgac aaggacgacg tgaacggcaa ctacgagaag     3600

attaattaca agctgctccc cggccccaac aagatgctcc cgaaggtgtt ctttagcaag     3660

aagtggatgg cctactacaa cccgagcgag gacatccaga agatctataa gaatggcacc     3720

ttcaagaagg gagacatgtt taacctcaac gactgccaca agctgattga cttcttcaag     3780

gactcgatct cgcgctaccc gaagtggtcg aacgcctacg acttcaactt cagcgaaacg     3840

gagaaataca aagacatcgc gggcttctac cgcgaggtcg aggagcaagg ctacaaggtc     3900

agcttcgagt ccgccagcaa gaaggaggtg gacaagctgg tggaggaggg caagctctac     3960

atgtttcaga tctacaacaa ggattttagc gacaagtcgc acggcacgcc gaacctgcac     4020

acgatgtact tcaagctgct gttcgacgag aacaaccacg gccagatccg gctgtcgggc     4080

ggtgcggagc tgttcatgcg ccgggcgtcg ctcaagaagg aagagctggt cgtccacccg     4140

gccaacagcc ccatcgccaa caagaacccc gacaacccca agaaaacgac gacactcagc     4200

tatgatgtct ataaagacaa gcgcttctcg gaggaccagt acgagctgca catccccatc     4260

gccatcaaca agtgccccaa gaacatcttc aagatcaaca cggaggtccg cgtgctcctc     4320

aagcacgacg acaacccgta cgtcatcggc atcgaccggg gcgagcgcaa cctgctgtac     4380

atcgtcgtcg tcgatggcaa gggcaacatc gtggagcagt attccctgaa cgagatcatc     4440

aacaacttca acggcatccg catcaagacc gactaccact ccctcctcga caagaaggag     4500

aaagagcgct tcgaggcccg ccagaactgg acctccatcg agaacatcaa ggagcttaag     4560

gcgggctaca tctcccaagt cgtccacaag atctgcgagc tggtcgagaa gtacgacgcg     4620

gtgatcgccc tggaagacct gaactccggc ttcaagaact cccgcgtaaa ggtggagaag     4680

caagtgtacc agaagttcga gaagatgctg atcgacaagc tgaactacat ggtggacaag     4740

aaatcgaacc cgtgcgcgac cggcggcgcg ctcaagggct accagatcac gaacaagttc     4800

gagtcgttca agtccatgag cacgcagaac ggctttatct tctacatccc ggcctggctg     4860

acgtcgaaga tcgacccctc gaccggcttc gtgaacctgc tcaagaccaa gtatactagc     4920

attgccgact ccaagaaatt catctcgtcc ttcgaccgca tcatgtacgt cccggaggag     4980

gacctttttg agttcgccct cgactacaag aacttcagcc gcaccgacgc cgactacatc     5040

aagaagtgga agctgtactc gtacgggaac cgcatccgta tttttcgcaa cccgaagaaa     5100

aataatgtct tcgactggga ggaggtgtgc ctgaccagcg cctacaagga gctgttcaac     5160

aagtacggca tcaactacca acagggcgac atccgggccc ttctctgcga gcagagcgac     5220

aaggcgttct actcgtcgtt catggccctg atgagcctga tgctccagat gaggaacagc     5280

atcaccggcc gcaccgacgt ggacttcctc atcagccccg tcaagaactc ggacggcata     5340

ttttatgact cgcggaacta cgaggcccag gagaacgcca tcctgcccaa gaacgccgac     5400

gccaacggcg cgtacaacat cgcccgcaag gtgctctggg ccatcggcca gttcaagaag     5460

gcggaagacg agaagctgga caaggtgaag atcgccatct ccaacaagga gtggctggag     5520

tacgcgcaga cgtccgtcaa gcacggctcc aagaaacggc ggatcaaaca agattccggt     5580

ggcagttccg gtggcagcag tgcgtcgtta gcaagaggcg gtccaaatgc agtgggactc     5640

ctaacgacga acgaaagctt tgagaaaaat atcaatgagg tctacaaccg tacgcgagcc     5700

gagctagacg cttcttcacg tgacagaagt cgctctggac tatcgcgata atctagacca     5760

ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt atctgttgtt     5820

tgtcggtgaa cgctctctac tagagtcaca ctggctcacc ttcgggtggg cctttctgcg     5880

tttatagtac gatatcccaa tggcgcgccg agcttggctc gagcatggtc atagctgttt     5940

cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag     6000

tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg     6060

cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg     6120

gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct cgctcactga ctcgctgcgc     6180

tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc     6240

acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg     6300

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     6360

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     6420

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     6480

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg     6540

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     6600

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     6660

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     6720

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt     6780

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     6840

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     6900

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     6960

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     7020

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     7080

tctgacagtt agaaaaactc atcgagcatc aaatgaaact gcaatttatt catatcagga     7140

ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg     7200

cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg tccaacatca     7260

atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa atcaccatga     7320

gtgacgactg aatccggtga gaatggcaaa agtttatgca tttctttcca gacttgttca     7380

acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc gttattcatt     7440

cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt taaaaggaca attacaaaca     7500

ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt ttcacctgaa     7560

tcaggatatt cttctaatac ctggaatgct gttttcccag ggatcgcagt ggtgagtaac     7620

catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat aaattccgtc     7680

agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc tttgccatgt     7740

ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt cgcacctgat     7800

tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat gttggaattt     7860

aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc tcatactctt cctttttcaa     7920

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt     7980

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc     8040

taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt     8100

tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagact     8160

gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg     8220

ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat tgtactgaga     8280

gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg     8340

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg     8400

ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca     8460

gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgacgcg ttgcggctgc     8520

atgaaatcct ggccggtttg tctgatgcca agctggcggc ctggccggcc agcttggccg     8580

ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt atttgagtaa aacagcttgc     8640

gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa acaaatacgc aaggggaacg     8700

catgaaggtt atcgctgtac ttaaccagaa aggcgggtca ggcaagacga ccatcgcaac     8760

ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt ctgttagtcg attccgatcc     8820

ccagggcagt gcccgcgatt gggcggccgt gcgggaagat caaccgctaa ccgttgtcgg     8880

catcgaccgc ccgacgattg accgcgacgt gaaggccatc ggccggcgcg acttcgtagt     8940

gatcgacgga gcgccccagg cggcggactt ggctgtgtcc gcgatcaagg cagccgactt     9000

cgtgctgatt ccggtgcagc caagccctta cgacatatgg gccaccgccg acctggtgga     9060

gctggttaag cagcgcattg aggtcacgga tggaaggcta caagcggcct ttgtcgtgtc     9120

gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc gaggcgctgg ccgggtacga     9180

gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc tacccaggca ctgccgccgc     9240

cggcacaacc gttcttgaat cagaacccga gggcgacgct gcccgcgagg tccaggcgct     9300

ggccgctgaa attaaatcaa aactcatttg agttaatgag gtaaagagaa aatgagcaaa     9360

agcacaaaca cgctaagtgc cggccgtccg agcgcacgca gcagcaaggc tgcaacgttg     9420

gccagcctgg cagacacgcc agccatgaag cgggtcaact ttcagttgcc ggcggaggat     9480

cacaccaagc tgaagatgta cgcggtacgc caaggcaaga ccattaccga gctgctatct     9540

gaatacatcg cgcagctacc agagtaaatg agcaaatgaa taaatgagta gatgaatttt     9600

agcggctaaa ggaggcggca tggaaaatca agaacaacca ggcaccgacg ccgtggaatg     9660

ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc ggctgggttg tctgccggcc     9720

ctgcaatggc actggaaccc ccaagcccga ggaatcggcg tgagcggtcg caaaccatcc     9780

ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg tggagaagtt gaaggccgcg     9840

caggccgccc agcggcaacg catcgaggca gaagcacgcc ccggtgaatc gtggcaagcg     9900

gccgctgatc gaatccgcaa agaatcccgg caaccgccgg cagccggtgc gccgtcgatt     9960

aggaagccgc ccaagggcga cgagcaacca gattttttcg ttccgatgct ctatgacgtg    10020

ggcacccgcg atagtcgcag catcatggac gtggccgttt tccgtctgtc gaagcgtgac    10080

cgacgagctg gcgaggtgat ccgctacgag cttccagacg ggcacgtaga ggtttccgca    10140

gggccggccg gcatggccag tgtgtgggat tacgacctgg tactgatggc ggtttcccat    10200

ctaaccgaat ccatgaaccg ataccgggaa gggaagggag acaagcccgg ccgcgtgttc    10260

cgtccacacg ttgcggacgt actcaagttc tgccggcgag ccgatggcgg aaagcagaaa    10320

gacgacctgg tagaaacctg cattcggtta aacaccacgc acgttgccat gcagcgtacg    10380

aagaaggcca agaacggccg cctggtgacg gtatccgagg gtgaagcctt gattagccgc    10440

tacaagatcg taaagagcga aaccgggcgg ccggagtaca tcgagatcga gctagctgat    10500

tggatgtacc gcgagatcac agaaggcaag aacccggacg tgctgacggt tcaccccgat    10560

tactttttga tcgatcccgg catcggccgt tttctctacc gcctggcacg ccgcgccgca    10620

ggcaaggcag aagccagatg gttgttcaag acgatctacg aacgcagtgg cagcgccgga    10680

gagttcaaga agttctgttt caccgtgcgc aagctgatcg ggtcaaatga cctgccggag    10740

tacgatttga aggaggaggc ggggcaggct ggcccgatcc tagtcatgcg ctaccgcaac    10800

ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg agcagatgct agggcaaatt    10860

gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg tggatagcac gtacattggg    10920

aacccaaagc cgtacattgg gaaccggaac ccgtacattg ggaacccaaa gccgtacatt    10980

gggaaccggt cacacatgta agtgactgat ataaaagaga aaaaaggcga tttttccgcc    11040

taaaactctt taaaacttat taaaactctt aaaacccgcc tggcctgtgc atatgctagt    11100

catgccccgc                                                           11110


<210>  149
<211>  28
<212>  DNA
<213>  Polyubiquitin left flank primer

<400>  149
gttgattctg tagtcgtaga ttaaggtt                                          28


<210>  150
<211>  12425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3910 Full Plasmid Sequence

<400>  150
gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt       60

gcctaatgag tgagctaact tacattaatt gcgttgcgcc ccgagagcgt tcaccgacaa      120

acaacagata aaacgaaagg cccagtcttt cgactgagcc tttcgtttta tttgatgcct      180

ggttacctcg aaagcccgct gcgcgagcgg tcacgcgatg aggcatccag ctccgctcgg      240

gtgcggttat agacctcatt gatatttttc tcgaaggatt cgtttgtcgt cagaaggccc      300

actgcgttag ggccgcctct ggcgaggctg gccgaagagc caccactgct gccgcccgaa      360

tcctgtttga tccgacgctt cttgctacca gcagaataaa tgccggagtt cgcggcaata      420

gcggacggga tcggatttcc atccttgagg aggccctgca tcgccttgac gatcaattcg      480

cagtcggagt tcgttgcgaa tatcgggatg gtgagttcca tgttcaggta gctgcgccag      540

gccgccaccg gcagttcaac gccgcccacg gtctgcgtcg caactttggg aacctcgacc      600

ttgatggtgt acttccgctt ctgggccgat gactggcgga cggagcaggt cactttatac      660

gcttgggacc gcgagttgct ggagatccat tccgccactc cattggcaaa attcgagggg      720

gctacggtga catcacccgt accgccgttg tcgaccagga cgaattgagt gaaattgctg      780

gcgtcctgct tgatgcggcg cttcttggac ccgctcatgg tacctcccca tctccccaag      840

ctcataacca acacagccac ttcggtcgga agaaatgctg tcatctgatg ttcacgatta      900

tcgggagggt cggttactct aggatttttg ttttcttctt ttcgatttca tttgaagcga      960

aaacggcttt ccatgcactt aagggtgcgc cgacgaaaga tggctctcta agacaacggc     1020

gaggatctag aatgccgtcg aagtgaaatt ccagggcgga atgaacgggg gatggttcca     1080

ataaactgtg gcacttcgca ggctccgatc agggtgtcga tcgcgccatt tgcgtggcga     1140

gggtatccgc ctatgccgac tatcctatgt ccgagctcag cgaacatatg tcttgttctt     1200

cgaagacggt atcgaagacc tccagcagat aatcgccaac cttcgggtct cagaagacgc     1260

accgccacaa ccgactgccc aaagcgattg cgagaaacca tagctatagg cgcgccgaac     1320

agacgtgctg attaccctgg tcgagtctcc ttaattaaca aaaaacccct caagacccgt     1380

ttagaggccc caaggggtta tgctagttat tgctcagcgg aatctacact tagtagaaat     1440

tagggaacac gagcgacatg ggtgatcctc atgtcgctcg tggcacatgg gtgatcctca     1500

tgtgctccct atccacatgt gtttttagta aaatctacac ttagtagaaa ttatttaatc     1560

tttgaaacgc tagcattata cctaggactg agctagctgt caacaattgg ggatgagatt     1620

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta     1680

aagtatatat gtgtaacatt ggtctagtga ttggatcctt gacagctagc tcagtcctag     1740

gtactgtgct agcgctagca aagaggagaa aggtaccatg cccgatcgag ctcaagttat     1800

cattcgcatt gtgccgggag gtggcaccaa gacccttcaa caaattatca atcagttgga     1860

gtatctatcc cggaagggca ggctggagct gcagcgttca gcccgacatc tcgatattcc     1920

cctgccaccg gatcaaatcc acgaacttgc ccgaagctgg gttcaagaga ctggaactta     1980

tgacgaaagt cagccagacg aggaaaggca acaggagttg accacccata ttattgtaag     2040

cttccccgcc ggtacaagcc aggtagcggc ttatgcggcg agccgggagt gggcagccga     2100

gatgtttggg tcaggcgcag gggggggccg atacaactat cttacggcct tccacatcga     2160

tcgcgaccac ccacatctgc atgtcgtcgt caatcggcgc gaacttttag gacacggctg     2220

gctgaagata tctcggcgcc atccccaact gaattacgac gccctgcgca taaagatggc     2280

cgagatttca cttcgtcatg gcattgccct cgatgcgagc cgacgagcag aacgtggcat     2340

caccgagcgg ccgatcactt atgcccaata tcggcgcctt gagcgggagc aggctcgcca     2400

aatccgtttc gaagacgcgg atttggaaca gtcgtcgccg caaggagatc atccagaatt     2460

cagccaacct ttcgatacat ccccatttga agcatccgcg ggcggaccgg aggacatgcc     2520

tcggcccaac aatcggcaga atgagtcgca agttcatctc caggagccag ctggtgtcag     2580

caacgaagcc ggtgtccttg tgcgggttgc attggaaacg gagcgccttg ctcaaccatt     2640

cgtttccgaa accattctcg cggacgacat agggagcggc tcttcgcgtg ttgccgaggg     2700

ccgtgtggag agcgcaaacc gcactcccga tattcctcgc gcagcaactg aagctgccac     2760

gcacacgaca cacgaccggc agcggcgtgc aaagcgtcct catgatgacg acggagggcc     2820

gagtggagca aaacgtgtga cattggaagg catcgcggtt gggccccagg cgaacgccgg     2880

cgaacaggat ggcagtagtg gccccttagt acggcaagct ggaacgtcac ggccatctcc     2940

accgacggcc acgacgcggg ccagcaccgc aaccgattca ttgtctgcta cagcccacct     3000

ccagcaacgg agaggtgtcc tttcaaagcg tccgcgtgaa gatgatgatg gagaaccgag     3060

tgaacgcaaa cgcgagagag atgagcgcag caaggacggg cgtgggggaa ataggagaag     3120

cggtggctcc tcgggtggca gcatgagcgg ctccaagaag cgccgcatca agcaagattc     3180

aaagctggag aagttcacca actgctactc gctgagcaag acgctgcggt tcaaggccat     3240

ccccgtgggc aagacccagg agaacatcga caacaagcgc ctcctggtcg aggacgagaa     3300

gcgcgccgag gactacaagg gcgtcaagaa gctcctggac cggtattacc tcagcttcat     3360

caacgacgtg ctgcactcga tcaagctcaa gaacctgaac aactacatca gcctgttccg     3420

caagaaaacg cgcaccgaga aggagaacaa agagctggag aacctggaga tcaacctgcg     3480

gaaggagatt gcgaaagctt tcaagggcaa cgagggctac aagtcgctct tcaagaaaga     3540

cataatcgag accatcctgc cggagttcct ggacgacaag gacgagatcg cgctcgtcaa     3600

ctcgttcaac gggttcacta cggccttcac gggtttcttc gataaccggg agaatatgtt     3660

tagcgaggag gccaagtcca cctccattgc gttccgctgc atcaacgaga acctgacccg     3720

ctacatcagc aacatggaca tcttcgagaa ggtggacgcc atcttcgaca agcacgaggt     3780

ccaggagatc aaggagaaga ttctgaactc ggactacgac gtggaagact tcttcgaggg     3840

cgagtttttc aacttcgtcc tgacccagga ggggatcgac gtttataacg ccatcatcgg     3900

cgggttcgtc acggagtcgg gcgaaaagat caagggcctg aacgagtata ttaacctgta     3960

caaccagaag acaaagcaga agctgccgaa gttcaagccg ctgtacaagc aagtcctgtc     4020

cgaccgcgag tcgctgtcgt tctacggcga aggctacacc tcggacgagg aggtgctgga     4080

ggtgttccgc aacaccctga acaagaatag cgaaattttt agctccatta agaagctcga     4140

gaagctgttc aagaacttcg acgagtacag cagcgccggg atcttcgtca agaacggccc     4200

cgcgatcagc accatctcga aggacatctt cggcgagtgg aacgtcatcc gggacaagtg     4260

gaacgccgag tacgacgaca ttcaccttaa aaagaaggct gttgtgacgg agaagtacga     4320

ggacgaccgg cgcaagtcgt tcaaaaagat cggctccttc tccctggagc agctccagga     4380

gtacgccgac gccgacctct cggtcgtcga gaagctcaag gagatcatca ttcagaaggt     4440

ggacgaaatt tacaaagtgt acggctccag cgagaagctg ttcgacgccg acttcgtgct     4500

ggaaaagtcg ctcaagaaaa acgacgccgt ggtggccatc atgaaggact tgctggacag     4560

cgtgaagtcg ttcgagaact acattaaggc gttctttggc gagggcaagg agaccaaccg     4620

cgacgagtcg ttctacggcg acttcgtgct cgcgtacgac atcctgctca aggtggatca     4680

catctacgac gcgatccgca actacgtcac gcagaagccg tactcgaagg acaagttcaa     4740

gctgtacttc cagaacccgc agttcatggg cgggtgggac aaggacaagg aaacggacta     4800

ccgcgcgacc atcctgcggt acggcagcaa gtattatctg gcgatcatgg acaaaaaata     4860

tgccaagtgc ctccagaaaa tcgacaagga cgacgtgaac ggcaactacg agaagattaa     4920

ttacaagctg ctccccggcc ccaacaagat gctcccgaag gtgttcttta gcaagaagtg     4980

gatggcctac tacaacccga gcgaggacat ccagaagatc tataagaatg gcaccttcaa     5040

gaagggagac atgtttaacc tcaacgactg ccacaagctg attgacttct tcaaggactc     5100

gatctcgcgc tacccgaagt ggtcgaacgc ctacgacttc aacttcagcg aaacggagaa     5160

atacaaagac atcgcgggct tctaccgcga ggtcgaggag caaggctaca aggtcagctt     5220

cgagtccgcc agcaagaagg aggtggacaa gctggtggag gagggcaagc tctacatgtt     5280

tcagatctac aacaaggatt ttagcgacaa gtcgcacggc acgccgaacc tgcacacgat     5340

gtacttcaag ctgctgttcg acgagaacaa ccacggccag atccggctgt cgggcggtgc     5400

ggagctgttc atgcgccggg cgtcgctcaa gaaggaagag ctggtcgtcc acccggccaa     5460

cagccccatc gccaacaaga accccgacaa ccccaagaaa acgacgacac tcagctatga     5520

tgtctataaa gacaagcgct tctcggagga ccagtacgag ctgcacatcc ccatcgccat     5580

caacaagtgc cccaagaaca tcttcaagat caacacggag gtccgcgtgc tcctcaagca     5640

cgacgacaac ccgtacgtca tcggcatcga ccggggcgag cgcaacctgc tgtacatcgt     5700

cgtcgtcgat ggcaagggca acatcgtgga gcagtattcc ctgaacgaga tcatcaacaa     5760

cttcaacggc atccgcatca agaccgacta ccactccctc ctcgacaaga aggagaaaga     5820

gcgcttcgag gcccgccaga actggacctc catcgagaac atcaaggagc ttaaggcggg     5880

ctacatctcc caagtcgtcc acaagatctg cgagctggtc gagaagtacg acgcggtgat     5940

cgccctggaa gacctgaact ccggcttcaa gaactcccgc gtaaaggtgg agaagcaagt     6000

gtaccagaag ttcgagaaga tgctgatcga caagctgaac tacatggtgg acaagaaatc     6060

gaacccgtgc gcgaccggcg gcgcgctcaa gggctaccag atcacgaaca agttcgagtc     6120

gttcaagtcc atgagcacgc agaacggctt tatcttctac atcccggcct ggctgacgtc     6180

gaagatcgac ccctcgaccg gcttcgtgaa cctgctcaag accaagtata ctagcattgc     6240

cgactccaag aaattcatct cgtccttcga ccgcatcatg tacgtcccgg aggaggacct     6300

ttttgagttc gccctcgact acaagaactt cagccgcacc gacgccgact acatcaagaa     6360

gtggaagctg tactcgtacg ggaaccgcat ccgtattttt cgcaacccga agaaaaataa     6420

tgtcttcgac tgggaggagg tgtgcctgac cagcgcctac aaggagctgt tcaacaagta     6480

cggcatcaac taccaacagg gcgacatccg ggcccttctc tgcgagcaga gcgacaaggc     6540

gttctactcg tcgttcatgg ccctgatgag cctgatgctc cagatgagga acagcatcac     6600

cggccgcacc gacgtggact tcctcatcag ccccgtcaag aactcggacg gcatatttta     6660

tgactcgcgg aactacgagg cccaggagaa cgccatcctg cccaagaacg ccgacgccaa     6720

cggcgcgtac aacatcgccc gcaaggtgct ctgggccatc ggccagttca agaaggcgga     6780

agacgagaag ctggacaagg tgaagatcgc catctccaac aaggagtggc tggagtacgc     6840

gcagacgtcc gtcaagcacg gctccaagaa acggcggatc aaacaagatt ccggtggcag     6900

ttccggtggc agcagtgcgt cgttagcaag aggcggtcca aatgcagtgg gactcctaac     6960

gacgaacgaa agctttgaga aaaatatcaa tgaggtctac aaccgtacgc gagccgagct     7020

agacgcttct tcacgtgaca gaagtcgctc tggactatcg cgataatcta gaccaggcat     7080

caaataaaac gaaaggctca gtcgaaagac tgggcctttc gttttatctg ttgtttgtcg     7140

gtgaacgctc tctactagag tcacactggc tcaccttcgg gtgggccttt ctgcgtttat     7200

agtacgatat cccaatggcg cgccgagctt ggctcgagca tggtcatagc tgtttcctgt     7260

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa     7320

agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc     7380

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     7440

aggcggtttg cgtattgggc gctgttccgc ttcctcgctc actgactcgc tgcgctcggt     7500

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     7560

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     7620

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     7680

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     7740

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     7800

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     7860

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     7920

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     7980

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     8040

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     8100

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     8160

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     8220

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     8280

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     8340

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     8400

cagttagaaa aactcatcga gcatcaaatg aaactgcaat ttattcatat caggattatc     8460

aataccatat ttttgaaaaa gccgtttctg taatgaagga gaaaactcac cgaggcagtt     8520

ccataggatg gcaagatcct ggtatcggtc tgcgattccg actcgtccaa catcaataca     8580

acctattaat ttcccctcgt caaaaataag gttatcaagt gagaaatcac catgagtgac     8640

gactgaatcc ggtgagaatg gcaaaagttt atgcatttct ttccagactt gttcaacagg     8700

ccagccatta cgctcgtcat caaaatcact cgcatcaacc aaaccgttat tcattcgtga     8760

ttgcgcctga gcgaaacgaa atacgcgatc gctgttaaaa ggacaattac aaacaggaat     8820

cgaatgcaac cggcgcagga acactgccag cgcatcaaca atattttcac ctgaatcagg     8880

atattcttct aatacctgga atgctgtttt cccagggatc gcagtggtga gtaaccatgc     8940

atcatcagga gtacggataa aatgcttgat ggtcggaaga ggcataaatt ccgtcagcca     9000

gtttagtctg accatctcat ctgtaacatc attggcaacg ctacctttgc catgtttcag     9060

aaacaactct ggcgcatcgg gcttcccata caatcgatag attgtcgcac ctgattgccc     9120

gacattatcg cgagcccatt tatacccata taaatcagca tccatgttgg aatttaatcg     9180

cggcctagag caagacgttt cccgttgaat atggctcata ctcttccttt ttcaatatta     9240

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     9300

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga     9360

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc ccttttgtct     9420

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agactgtcac     9480

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt     9540

tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca     9600

ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcaggcgcca     9660

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     9720

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     9780

ttcccagtca cgacgttgta aaacgacggc cagtgaattg acgcgttgcg gctgcatgaa     9840

atcctggccg gtttgtctga tgccaagctg gcggcctggc cggccagctt ggccgctgaa     9900

gaaaccgagc gccgccgtct aaaaaggtga tgtgtatttg agtaaaacag cttgcgtcat     9960

gcggtcgctg cgtatatgat gcgatgagta aataaacaaa tacgcaaggg gaacgcatga    10020

aggttatcgc tgtacttaac cagaaaggcg ggtcaggcaa gacgaccatc gcaacccatc    10080

tagcccgcgc cctgcaactc gccggggccg atgttctgtt agtcgattcc gatccccagg    10140

gcagtgcccg cgattgggcg gccgtgcggg aagatcaacc gctaaccgtt gtcggcatcg    10200

accgcccgac gattgaccgc gacgtgaagg ccatcggccg gcgcgacttc gtagtgatcg    10260

acggagcgcc ccaggcggcg gacttggctg tgtccgcgat caaggcagcc gacttcgtgc    10320

tgattccggt gcagccaagc ccttacgaca tatgggccac cgccgacctg gtggagctgg    10380

ttaagcagcg cattgaggtc acggatggaa ggctacaagc ggcctttgtc gtgtcgcggg    10440

cgatcaaagg cacgcgcatc ggcggtgagg ttgccgaggc gctggccggg tacgagctgc    10500

ccattcttga gtcccgtatc acgcagcgcg tgagctaccc aggcactgcc gccgccggca    10560

caaccgttct tgaatcagaa cccgagggcg acgctgcccg cgaggtccag gcgctggccg    10620

ctgaaattaa atcaaaactc atttgagtta atgaggtaaa gagaaaatga gcaaaagcac    10680

aaacacgcta agtgccggcc gtccgagcgc acgcagcagc aaggctgcaa cgttggccag    10740

cctggcagac acgccagcca tgaagcgggt caactttcag ttgccggcgg aggatcacac    10800

caagctgaag atgtacgcgg tacgccaagg caagaccatt accgagctgc tatctgaata    10860

catcgcgcag ctaccagagt aaatgagcaa atgaataaat gagtagatga attttagcgg    10920

ctaaaggagg cggcatggaa aatcaagaac aaccaggcac cgacgccgtg gaatgcccca    10980

tgtgtggagg aacgggcggt tggccaggcg taagcggctg ggttgtctgc cggccctgca    11040

atggcactgg aacccccaag cccgaggaat cggcgtgagc ggtcgcaaac catccggccc    11100

ggtacaaatc ggcgcggcgc tgggtgatga cctggtggag aagttgaagg ccgcgcaggc    11160

cgcccagcgg caacgcatcg aggcagaagc acgccccggt gaatcgtggc aagcggccgc    11220

tgatcgaatc cgcaaagaat cccggcaacc gccggcagcc ggtgcgccgt cgattaggaa    11280

gccgcccaag ggcgacgagc aaccagattt tttcgttccg atgctctatg acgtgggcac    11340

ccgcgatagt cgcagcatca tggacgtggc cgttttccgt ctgtcgaagc gtgaccgacg    11400

agctggcgag gtgatccgct acgagcttcc agacgggcac gtagaggttt ccgcagggcc    11460

ggccggcatg gccagtgtgt gggattacga cctggtactg atggcggttt cccatctaac    11520

cgaatccatg aaccgatacc gggaagggaa gggagacaag cccggccgcg tgttccgtcc    11580

acacgttgcg gacgtactca agttctgccg gcgagccgat ggcggaaagc agaaagacga    11640

cctggtagaa acctgcattc ggttaaacac cacgcacgtt gccatgcagc gtacgaagaa    11700

ggccaagaac ggccgcctgg tgacggtatc cgagggtgaa gccttgatta gccgctacaa    11760

gatcgtaaag agcgaaaccg ggcggccgga gtacatcgag atcgagctag ctgattggat    11820

gtaccgcgag atcacagaag gcaagaaccc ggacgtgctg acggttcacc ccgattactt    11880

tttgatcgat cccggcatcg gccgttttct ctaccgcctg gcacgccgcg ccgcaggcaa    11940

ggcagaagcc agatggttgt tcaagacgat ctacgaacgc agtggcagcg ccggagagtt    12000

caagaagttc tgtttcaccg tgcgcaagct gatcgggtca aatgacctgc cggagtacga    12060

tttgaaggag gaggcggggc aggctggccc gatcctagtc atgcgctacc gcaacctgat    12120

cgagggcgaa gcatccgccg gttcctaatg tacggagcag atgctagggc aaattgccct    12180

agcaggggaa aaaggtcgaa aaggtctctt tcctgtggat agcacgtaca ttgggaaccc    12240

aaagccgtac attgggaacc ggaacccgta cattgggaac ccaaagccgt acattgggaa    12300

ccggtcacac atgtaagtga ctgatataaa agagaaaaaa ggcgattttt ccgcctaaaa    12360

ctctttaaaa cttattaaaa ctcttaaaac ccgcctggcc tgtgcatatg ctagtcatgc    12420

cccgc                                                                12425


<210>  151
<211>  12425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3911 Full Plasmid Sequence

<400>  151
gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg agatcccggt       60

gcctaatgag tgagctaact tacattaatt gcgttgcgcc ccgagagcgt tcaccgacaa      120

acaacagata aaacgaaagg cccagtcttt cgactgagcc tttcgtttta tttgatgcct      180

ggttacctcg aaagcccgct gcgcgagcgg tcacgcgatg aggcatccag ctccgctcgg      240

gtgcggttat agacctcatt gatatttttc tcgaaggatt cgtttgtcgt cagaaggccc      300

actgcgttag ggccgcctct ggcgaggctg gccgaagagc caccactgct gccgcccgaa      360

tcctgtttga tccgacgctt cttgctacca gcagaataaa tgccggagtt cgcggcaata      420

gcggacggga tcggatttcc atccttgagg aggccctgca tcgccttgac gatcaattcg      480

cagtcggagt tcgttgcgaa tatcgggatg gtgagttcca tgttcaggta gctgcgccag      540

gccgccaccg gcagttcaac gccgcccacg gtctgcgtcg caactttggg aacctcgacc      600

ttgatggtgt acttccgctt ctgggccgat gactggcgga cggagcaggt cactttatac      660

gcttgggacc gcgagttgct ggagatccat tccgccactc cattggcaaa attcgagggg      720

gctacggtga catcacccgt accgccgttg tcgaccagga cgaattgagt gaaattgctg      780

gcgtcctgct tgatgcggcg cttcttggac ccgctcatgg tacctcccca tctccccaag      840

ctcataacca acacagccac ttcggtcgga agaaatgctg tcatctgatg ttcacgatta      900

tcgggagggt cggttactct aggatttttg ttttcttctt ttcgatttca tttgaagcga      960

aaacggcttt ccatgcactt aagggtgcgc cgacgaaaga tggctctcta agacaacggc     1020

gaggatctag aatgccgtcg aagtgaaatt ccagggcgga atgaacgggg gatggttcca     1080

ataaactgtg gcacttcgca ggctccgatc agggtgtcga tcgcgccatt tgcgtggcga     1140

gggtatccgc ctatgccgac tatcctatgt ccgagctcag cgaacatatg tcttgttctt     1200

cgaagacggt atcgaagacc tccagcagat aatcgccaac cttcgggtct cagaagacgc     1260

accgccacaa ccgactgccc aaagcgattg cgagaaacca tagctatagg cgcgccgaac     1320

agacgtgctg attaccctgg tcgagtctcc ttaattaaca aaaaacccct caagacccgt     1380

ttagaggccc caaggggtta tgctagttat tgctcagcgg aatctacact tagtagaaat     1440

tagggaacac gagcgacatg ggtgatcctc atgtcgctcg tggcacatgg gtgatcctca     1500

tgtgctcccc atggagggca cagttaagcc gcatctacac ttagtagaaa ttatttaatc     1560

tttgaaacgc tagcattata cctaggactg agctagctgt caacaattgg ggatgagatt     1620

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta     1680

aagtatatat gtgtaacatt ggtctagtga ttggatcctt gacagctagc tcagtcctag     1740

gtactgtgct agcgctagca aagaggagaa aggtaccatg cccgatcgag ctcaagttat     1800

cattcgcatt gtgccgggag gtggcaccaa gacccttcaa caaattatca atcagttgga     1860

gtatctatcc cggaagggca ggctggagct gcagcgttca gcccgacatc tcgatattcc     1920

cctgccaccg gatcaaatcc acgaacttgc ccgaagctgg gttcaagaga ctggaactta     1980

tgacgaaagt cagccagacg aggaaaggca acaggagttg accacccata ttattgtaag     2040

cttccccgcc ggtacaagcc aggtagcggc ttatgcggcg agccgggagt gggcagccga     2100

gatgtttggg tcaggcgcag gggggggccg atacaactat cttacggcct tccacatcga     2160

tcgcgaccac ccacatctgc atgtcgtcgt caatcggcgc gaacttttag gacacggctg     2220

gctgaagata tctcggcgcc atccccaact gaattacgac gccctgcgca taaagatggc     2280

cgagatttca cttcgtcatg gcattgccct cgatgcgagc cgacgagcag aacgtggcat     2340

caccgagcgg ccgatcactt atgcccaata tcggcgcctt gagcgggagc aggctcgcca     2400

aatccgtttc gaagacgcgg atttggaaca gtcgtcgccg caaggagatc atccagaatt     2460

cagccaacct ttcgatacat ccccatttga agcatccgcg ggcggaccgg aggacatgcc     2520

tcggcccaac aatcggcaga atgagtcgca agttcatctc caggagccag ctggtgtcag     2580

caacgaagcc ggtgtccttg tgcgggttgc attggaaacg gagcgccttg ctcaaccatt     2640

cgtttccgaa accattctcg cggacgacat agggagcggc tcttcgcgtg ttgccgaggg     2700

ccgtgtggag agcgcaaacc gcactcccga tattcctcgc gcagcaactg aagctgccac     2760

gcacacgaca cacgaccggc agcggcgtgc aaagcgtcct catgatgacg acggagggcc     2820

gagtggagca aaacgtgtga cattggaagg catcgcggtt gggccccagg cgaacgccgg     2880

cgaacaggat ggcagtagtg gccccttagt acggcaagct ggaacgtcac ggccatctcc     2940

accgacggcc acgacgcggg ccagcaccgc aaccgattca ttgtctgcta cagcccacct     3000

ccagcaacgg agaggtgtcc tttcaaagcg tccgcgtgaa gatgatgatg gagaaccgag     3060

tgaacgcaaa cgcgagagag atgagcgcag caaggacggg cgtgggggaa ataggagaag     3120

cggtggctcc tcgggtggca gcatgagcgg ctccaagaag cgccgcatca agcaagattc     3180

aaagctggag aagttcacca actgctactc gctgagcaag acgctgcggt tcaaggccat     3240

ccccgtgggc aagacccagg agaacatcga caacaagcgc ctcctggtcg aggacgagaa     3300

gcgcgccgag gactacaagg gcgtcaagaa gctcctggac cggtattacc tcagcttcat     3360

caacgacgtg ctgcactcga tcaagctcaa gaacctgaac aactacatca gcctgttccg     3420

caagaaaacg cgcaccgaga aggagaacaa agagctggag aacctggaga tcaacctgcg     3480

gaaggagatt gcgaaagctt tcaagggcaa cgagggctac aagtcgctct tcaagaaaga     3540

cataatcgag accatcctgc cggagttcct ggacgacaag gacgagatcg cgctcgtcaa     3600

ctcgttcaac gggttcacta cggccttcac gggtttcttc gataaccggg agaatatgtt     3660

tagcgaggag gccaagtcca cctccattgc gttccgctgc atcaacgaga acctgacccg     3720

ctacatcagc aacatggaca tcttcgagaa ggtggacgcc atcttcgaca agcacgaggt     3780

ccaggagatc aaggagaaga ttctgaactc ggactacgac gtggaagact tcttcgaggg     3840

cgagtttttc aacttcgtcc tgacccagga ggggatcgac gtttataacg ccatcatcgg     3900

cgggttcgtc acggagtcgg gcgaaaagat caagggcctg aacgagtata ttaacctgta     3960

caaccagaag acaaagcaga agctgccgaa gttcaagccg ctgtacaagc aagtcctgtc     4020

cgaccgcgag tcgctgtcgt tctacggcga aggctacacc tcggacgagg aggtgctgga     4080

ggtgttccgc aacaccctga acaagaatag cgaaattttt agctccatta agaagctcga     4140

gaagctgttc aagaacttcg acgagtacag cagcgccggg atcttcgtca agaacggccc     4200

cgcgatcagc accatctcga aggacatctt cggcgagtgg aacgtcatcc gggacaagtg     4260

gaacgccgag tacgacgaca ttcaccttaa aaagaaggct gttgtgacgg agaagtacga     4320

ggacgaccgg cgcaagtcgt tcaaaaagat cggctccttc tccctggagc agctccagga     4380

gtacgccgac gccgacctct cggtcgtcga gaagctcaag gagatcatca ttcagaaggt     4440

ggacgaaatt tacaaagtgt acggctccag cgagaagctg ttcgacgccg acttcgtgct     4500

ggaaaagtcg ctcaagaaaa acgacgccgt ggtggccatc atgaaggact tgctggacag     4560

cgtgaagtcg ttcgagaact acattaaggc gttctttggc gagggcaagg agaccaaccg     4620

cgacgagtcg ttctacggcg acttcgtgct cgcgtacgac atcctgctca aggtggatca     4680

catctacgac gcgatccgca actacgtcac gcagaagccg tactcgaagg acaagttcaa     4740

gctgtacttc cagaacccgc agttcatggg cgggtgggac aaggacaagg aaacggacta     4800

ccgcgcgacc atcctgcggt acggcagcaa gtattatctg gcgatcatgg acaaaaaata     4860

tgccaagtgc ctccagaaaa tcgacaagga cgacgtgaac ggcaactacg agaagattaa     4920

ttacaagctg ctccccggcc ccaacaagat gctcccgaag gtgttcttta gcaagaagtg     4980

gatggcctac tacaacccga gcgaggacat ccagaagatc tataagaatg gcaccttcaa     5040

gaagggagac atgtttaacc tcaacgactg ccacaagctg attgacttct tcaaggactc     5100

gatctcgcgc tacccgaagt ggtcgaacgc ctacgacttc aacttcagcg aaacggagaa     5160

atacaaagac atcgcgggct tctaccgcga ggtcgaggag caaggctaca aggtcagctt     5220

cgagtccgcc agcaagaagg aggtggacaa gctggtggag gagggcaagc tctacatgtt     5280

tcagatctac aacaaggatt ttagcgacaa gtcgcacggc acgccgaacc tgcacacgat     5340

gtacttcaag ctgctgttcg acgagaacaa ccacggccag atccggctgt cgggcggtgc     5400

ggagctgttc atgcgccggg cgtcgctcaa gaaggaagag ctggtcgtcc acccggccaa     5460

cagccccatc gccaacaaga accccgacaa ccccaagaaa acgacgacac tcagctatga     5520

tgtctataaa gacaagcgct tctcggagga ccagtacgag ctgcacatcc ccatcgccat     5580

caacaagtgc cccaagaaca tcttcaagat caacacggag gtccgcgtgc tcctcaagca     5640

cgacgacaac ccgtacgtca tcggcatcga ccggggcgag cgcaacctgc tgtacatcgt     5700

cgtcgtcgat ggcaagggca acatcgtgga gcagtattcc ctgaacgaga tcatcaacaa     5760

cttcaacggc atccgcatca agaccgacta ccactccctc ctcgacaaga aggagaaaga     5820

gcgcttcgag gcccgccaga actggacctc catcgagaac atcaaggagc ttaaggcggg     5880

ctacatctcc caagtcgtcc acaagatctg cgagctggtc gagaagtacg acgcggtgat     5940

cgccctggaa gacctgaact ccggcttcaa gaactcccgc gtaaaggtgg agaagcaagt     6000

gtaccagaag ttcgagaaga tgctgatcga caagctgaac tacatggtgg acaagaaatc     6060

gaacccgtgc gcgaccggcg gcgcgctcaa gggctaccag atcacgaaca agttcgagtc     6120

gttcaagtcc atgagcacgc agaacggctt tatcttctac atcccggcct ggctgacgtc     6180

gaagatcgac ccctcgaccg gcttcgtgaa cctgctcaag accaagtata ctagcattgc     6240

cgactccaag aaattcatct cgtccttcga ccgcatcatg tacgtcccgg aggaggacct     6300

ttttgagttc gccctcgact acaagaactt cagccgcacc gacgccgact acatcaagaa     6360

gtggaagctg tactcgtacg ggaaccgcat ccgtattttt cgcaacccga agaaaaataa     6420

tgtcttcgac tgggaggagg tgtgcctgac cagcgcctac aaggagctgt tcaacaagta     6480

cggcatcaac taccaacagg gcgacatccg ggcccttctc tgcgagcaga gcgacaaggc     6540

gttctactcg tcgttcatgg ccctgatgag cctgatgctc cagatgagga acagcatcac     6600

cggccgcacc gacgtggact tcctcatcag ccccgtcaag aactcggacg gcatatttta     6660

tgactcgcgg aactacgagg cccaggagaa cgccatcctg cccaagaacg ccgacgccaa     6720

cggcgcgtac aacatcgccc gcaaggtgct ctgggccatc ggccagttca agaaggcgga     6780

agacgagaag ctggacaagg tgaagatcgc catctccaac aaggagtggc tggagtacgc     6840

gcagacgtcc gtcaagcacg gctccaagaa acggcggatc aaacaagatt ccggtggcag     6900

ttccggtggc agcagtgcgt cgttagcaag aggcggtcca aatgcagtgg gactcctaac     6960

gacgaacgaa agctttgaga aaaatatcaa tgaggtctac aaccgtacgc gagccgagct     7020

agacgcttct tcacgtgaca gaagtcgctc tggactatcg cgataatcta gaccaggcat     7080

caaataaaac gaaaggctca gtcgaaagac tgggcctttc gttttatctg ttgtttgtcg     7140

gtgaacgctc tctactagag tcacactggc tcaccttcgg gtgggccttt ctgcgtttat     7200

agtacgatat cccaatggcg cgccgagctt ggctcgagca tggtcatagc tgtttcctgt     7260

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa     7320

agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc     7380

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     7440

aggcggtttg cgtattgggc gctgttccgc ttcctcgctc actgactcgc tgcgctcggt     7500

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     7560

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     7620

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     7680

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     7740

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     7800

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     7860

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     7920

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     7980

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     8040

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     8100

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     8160

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     8220

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     8280

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     8340

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     8400

cagttagaaa aactcatcga gcatcaaatg aaactgcaat ttattcatat caggattatc     8460

aataccatat ttttgaaaaa gccgtttctg taatgaagga gaaaactcac cgaggcagtt     8520

ccataggatg gcaagatcct ggtatcggtc tgcgattccg actcgtccaa catcaataca     8580

acctattaat ttcccctcgt caaaaataag gttatcaagt gagaaatcac catgagtgac     8640

gactgaatcc ggtgagaatg gcaaaagttt atgcatttct ttccagactt gttcaacagg     8700

ccagccatta cgctcgtcat caaaatcact cgcatcaacc aaaccgttat tcattcgtga     8760

ttgcgcctga gcgaaacgaa atacgcgatc gctgttaaaa ggacaattac aaacaggaat     8820

cgaatgcaac cggcgcagga acactgccag cgcatcaaca atattttcac ctgaatcagg     8880

atattcttct aatacctgga atgctgtttt cccagggatc gcagtggtga gtaaccatgc     8940

atcatcagga gtacggataa aatgcttgat ggtcggaaga ggcataaatt ccgtcagcca     9000

gtttagtctg accatctcat ctgtaacatc attggcaacg ctacctttgc catgtttcag     9060

aaacaactct ggcgcatcgg gcttcccata caatcgatag attgtcgcac ctgattgccc     9120

gacattatcg cgagcccatt tatacccata taaatcagca tccatgttgg aatttaatcg     9180

cggcctagag caagacgttt cccgttgaat atggctcata ctcttccttt ttcaatatta     9240

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa     9300

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga     9360

aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc ccttttgtct     9420

cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agactgtcac     9480

agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt     9540

tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca     9600

ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcaggcgcca     9660

ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct cttcgctatt     9720

acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa cgccagggtt     9780

ttcccagtca cgacgttgta aaacgacggc cagtgaattg acgcgttgcg gctgcatgaa     9840

atcctggccg gtttgtctga tgccaagctg gcggcctggc cggccagctt ggccgctgaa     9900

gaaaccgagc gccgccgtct aaaaaggtga tgtgtatttg agtaaaacag cttgcgtcat     9960

gcggtcgctg cgtatatgat gcgatgagta aataaacaaa tacgcaaggg gaacgcatga    10020

aggttatcgc tgtacttaac cagaaaggcg ggtcaggcaa gacgaccatc gcaacccatc    10080

tagcccgcgc cctgcaactc gccggggccg atgttctgtt agtcgattcc gatccccagg    10140

gcagtgcccg cgattgggcg gccgtgcggg aagatcaacc gctaaccgtt gtcggcatcg    10200

accgcccgac gattgaccgc gacgtgaagg ccatcggccg gcgcgacttc gtagtgatcg    10260

acggagcgcc ccaggcggcg gacttggctg tgtccgcgat caaggcagcc gacttcgtgc    10320

tgattccggt gcagccaagc ccttacgaca tatgggccac cgccgacctg gtggagctgg    10380

ttaagcagcg cattgaggtc acggatggaa ggctacaagc ggcctttgtc gtgtcgcggg    10440

cgatcaaagg cacgcgcatc ggcggtgagg ttgccgaggc gctggccggg tacgagctgc    10500

ccattcttga gtcccgtatc acgcagcgcg tgagctaccc aggcactgcc gccgccggca    10560

caaccgttct tgaatcagaa cccgagggcg acgctgcccg cgaggtccag gcgctggccg    10620

ctgaaattaa atcaaaactc atttgagtta atgaggtaaa gagaaaatga gcaaaagcac    10680

aaacacgcta agtgccggcc gtccgagcgc acgcagcagc aaggctgcaa cgttggccag    10740

cctggcagac acgccagcca tgaagcgggt caactttcag ttgccggcgg aggatcacac    10800

caagctgaag atgtacgcgg tacgccaagg caagaccatt accgagctgc tatctgaata    10860

catcgcgcag ctaccagagt aaatgagcaa atgaataaat gagtagatga attttagcgg    10920

ctaaaggagg cggcatggaa aatcaagaac aaccaggcac cgacgccgtg gaatgcccca    10980

tgtgtggagg aacgggcggt tggccaggcg taagcggctg ggttgtctgc cggccctgca    11040

atggcactgg aacccccaag cccgaggaat cggcgtgagc ggtcgcaaac catccggccc    11100

ggtacaaatc ggcgcggcgc tgggtgatga cctggtggag aagttgaagg ccgcgcaggc    11160

cgcccagcgg caacgcatcg aggcagaagc acgccccggt gaatcgtggc aagcggccgc    11220

tgatcgaatc cgcaaagaat cccggcaacc gccggcagcc ggtgcgccgt cgattaggaa    11280

gccgcccaag ggcgacgagc aaccagattt tttcgttccg atgctctatg acgtgggcac    11340

ccgcgatagt cgcagcatca tggacgtggc cgttttccgt ctgtcgaagc gtgaccgacg    11400

agctggcgag gtgatccgct acgagcttcc agacgggcac gtagaggttt ccgcagggcc    11460

ggccggcatg gccagtgtgt gggattacga cctggtactg atggcggttt cccatctaac    11520

cgaatccatg aaccgatacc gggaagggaa gggagacaag cccggccgcg tgttccgtcc    11580

acacgttgcg gacgtactca agttctgccg gcgagccgat ggcggaaagc agaaagacga    11640

cctggtagaa acctgcattc ggttaaacac cacgcacgtt gccatgcagc gtacgaagaa    11700

ggccaagaac ggccgcctgg tgacggtatc cgagggtgaa gccttgatta gccgctacaa    11760

gatcgtaaag agcgaaaccg ggcggccgga gtacatcgag atcgagctag ctgattggat    11820

gtaccgcgag atcacagaag gcaagaaccc ggacgtgctg acggttcacc ccgattactt    11880

tttgatcgat cccggcatcg gccgttttct ctaccgcctg gcacgccgcg ccgcaggcaa    11940

ggcagaagcc agatggttgt tcaagacgat ctacgaacgc agtggcagcg ccggagagtt    12000

caagaagttc tgtttcaccg tgcgcaagct gatcgggtca aatgacctgc cggagtacga    12060

tttgaaggag gaggcggggc aggctggccc gatcctagtc atgcgctacc gcaacctgat    12120

cgagggcgaa gcatccgccg gttcctaatg tacggagcag atgctagggc aaattgccct    12180

agcaggggaa aaaggtcgaa aaggtctctt tcctgtggat agcacgtaca ttgggaaccc    12240

aaagccgtac attgggaacc ggaacccgta cattgggaac ccaaagccgt acattgggaa    12300

ccggtcacac atgtaagtga ctgatataaa agagaaaaaa ggcgattttt ccgcctaaaa    12360

ctctttaaaa cttattaaaa ctcttaaaac ccgcctggcc tgtgcatatg ctagtcatgc    12420

cccgc                                                                12425


<210>  152
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tobacco PDS PCR Primer Reverse

<400>  152
ttcaaaccgc tcctaattgc tg                                                22


<210>  153
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tobacco PDS PCR Primer Forward

<400>  153
catagtccac aacgtgaaac ac                                                22


<210>  154
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yeast URA3 PCR Primer Reverse

<400>  154
ttagcatccc ttccctttgc                                                   20


<210>  155
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yeast URA3 PCR Primer Forward

<400>  155
gcgaggcata tttatggtga ag                                                22


<210>  156
<211>  10901
<212>  DNA
<213>  Nicotiana bethamiana


<220>
<221>  misc_feature
<222>  (3734)..(4041)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5335)..(5335)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6264)..(6264)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6646)..(7576)
<223>  n is a, c, g, or t

<400>  156
cattcattta cagatctaca aagattctta tcatatttgt ttacgattta cccctatata       60

ttttcgatta tttttaggct tataaaatac gaatataatt tctgagttaa ataatagacc      120

ttttttggtt tccttactaa aacactcatt cgacttttct ttttcacccg agacaaaaag      180

atattcacta tatttaaaat gggtataatt cataagaaca aaatataatc tcgaaaagat      240

taaattgcac gtgtacaaaa tttataagat gttgaatgga gtctcagtaa gttaggtaca      300

catttaggca tatacagaaa agattgatat aaatttcctt tttatattaa aaaaatgtaa      360

tttactatag aatacaaaga agaaacaatt actactacta ggaaccatca acggataagg      420

ttatttctct cttaaccaaa agttttgtgt tcgagtcgag tacttatgaa aaaatttgtc      480

cgagcggggt tatgtgcggt acggatttca atataatcga gttttaatac ggatatcgaa      540

cactgaatta aaaactaaaa aagaattgtg aaaatagcat gggttagcta gttttcggat      600

tggtaattaa aaaatagcca gcatttataa agtcattgaa aaataataac tattttgcta      660

caaattcaaa tataatgtaa ttggtgcacg aacttctagc atattatgat ggaactccaa      720

cacacaaaaa atttcaaaat aatatactga aaattggagt acctatgtat gaactttcag      780

aatattatac cggatcaata tattatgctg aaatattttt cggactttaa ataatttctt      840

tatttaaatt tatttttata caaaaataac taaatttcaa ttacttttaa aattatgatt      900

atttttcaat taccacttat acatcctgct attttgaatt tcacccgaaa gaactactac      960

tatacgtgga tcctcaatga cccagtaacc caagtgggag atgtgtgcaa agtggtcaaa     1020

tcttagaagg aatgagcaaa gcaagaaatt aaaaagagag acagagaggt gttatccatc     1080

aaatgtggct atggtcggaa tagccaatgg tgggacagtc tagccaaaca taaaggccgg     1140

tccagtgcga gttgctgcaa attgagttgg agtaaaaaat taagatacca tatttccagc     1200

taaatagcaa acaaatgacc caccattaac ggaagtggcc aaaccaccaa attcaggcat     1260

ctccaccaaa aattagtttt ttatacacga aagattcaac aattagtatt tctttaagcc     1320

ttcctaattc tttgtcaggg gtatcttttt gtgggtaaca gccaaaccac cacaaatttt     1380

cagttcccac tcttaactct ttttaacttc aacacaacaa attttttgct tttccttctt     1440

tgtttatctt gtgcataacg atttcctaca actttagcat aatcttggtt tgtaatccac     1500

aacgtgaaac acatcaccta ggcggtttca taccgaggta acaaatgatt ttggtttctt     1560

tggttacatc agctgaatgc tttacttgag aaaagctttc tccttttccc gtttaggatc     1620

ttgtttattt gctttcgttt ttctactcgt taaaatttta acttgatttt gtgggtgaat     1680

tataacttta ctcatagtgc gagaacaagt ttcgtatgga ctgtaaaagc tagaatcttt     1740

tttacttttg catataaatt tgtgtaataa atgcttaaga accagaatat tgaaaaaaca     1800

aaggaattct acatagtatt taggttcaca agtgggacaa tcttcttaca gtgaaatatc     1860

tttatgtcag gcttaattta ctgctatttt gttcagtaaa atgccccaaa ttggacttgt     1920

ttctgccgtt aatttgagag tccaaggtaa ttcagcttat ctttggagct cgaggtcttc     1980

tttgggaact gaaagtcaag atggtcgctt gcaaaggaat ttgttatgtt ttggtagtag     2040

cgactccatg gggcataagt ttagaattcg tactcccagt gccatgacca gaagattgac     2100

aaaggacttc aatcctttaa aggtttgttt tgaatgcgaa agtgtgatgc tgaatttatg     2160

atcacgagca tatattctct aaaataagat atcttgccat tcaggtagtc tgcattgatt     2220

atccaagacc ggagctagac aatacagtta actatttgga ggcggcgtta tcatcatcat     2280

catttcgtac ttcctcacgc ccaacaaaac cattggagat tgttattgct ggtgcaggtg     2340

attttttcca gtcatctata tttgtagtct tcatttttct ttctttggaa ggaagatcat     2400

tctattagtt gtattatcac tagaacattt attgtgcatt cttttcttat taactgtttt     2460

ggaccgcaaa attttaagtt cttacttctt cgcctcccaa ctgattagat taggagtgat     2520

ttgaaaatta gtttgttttg agctattttt gccgtcactc atatactgtt gagttgtccc     2580

acatcggtga gatttgaagt ccttggtctc acctcataag ttagcttttg gggttgagtt     2640

aggcccaata tccatttatc atagtacgag agccaggccc atcccagtta ttgttaccaa     2700

tgtcgggctc ctatttatgt tgtccacgct ccagtttgca agcctaggcg tgggggaggg     2760

gggtgttgag ttgtcccaca tccgtgggat ttgaggtact tggtctcctt atatggtctt     2820

ggacaatcca taagctagct tttggggttg agttcggccc aatgttcatt tatcatatat     2880

atatatatat atatatatgt ctattctctc ttaccatctg agccatgata agcgggtgaa     2940

cgtgctgtct attggatggc atgtccgatg gatcattccg aaatattgga ggcagatgaa     3000

ccaatacctt gtgcaagatt gatatcacta tacctataat cagagtactt agagttccaa     3060

aaatttgcag aacccattga aaagtcaaac aagttacata taggggttgc actcttctaa     3120

ggcttgcaat ctgtgagaaa aagatgagaa ggagatcttc atatttcatc tttattaggc     3180

tggaccattg accggttagc agttttgaac ttgttcttca acttggcttg catagtactg     3240

tgccgatcat ttcttttgta ttgtcatcaa ctggttgatt atttgagtac ctaaagaaag     3300

aatgttatgc atgatacatt gtgctgtact ataaaagata taataaagaa tgctagccga     3360

ggtactacat ggccttttca gacaaataga agctgtagca tgattctaat tcgatttgtt     3420

ttgaaatatc aggtttgggt ggcttgtcta cagcaaaata tctggcagat gctggtcaca     3480

aaccgatatt gctggaggca agagatgtcc taggtggaaa ggtgaagaat atccaatctt     3540

tcctttaatt ttattccttt ttcttctgtg tccttgccta ttggtagtcc ctgttcagga     3600

aggcttctgt ttgttttatt taaaatcatt tttcatactc tttaaacatt cagttgctca     3660

aacaattgca agggtgttca ctattcctat ttttgactgt cttactttct ctcagtttag     3720

ttttattccc ctcnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     3780

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     3840

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     3900

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     3960

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     4020

nnnnnnnnnn nnnnnnnnnn nccccccccc tgtctctctc tctctctctg tttttggagg     4080

aaatagatct gtcctaaaaa cttccagctt tactactaat agtgttaatt gtcgagaaaa     4140

tattacagca tattaggtat atggaaagta tattattatt ctctattatt ttaagattga     4200

gtcaatttta cccgtcctgt tggttgcatt tctcacataa acagtctttt ctgtgagatg     4260

ctatgttaat tagctgatgt ttttggtata gagcactatg ttagttttat ctttactgaa     4320

gcagtcacca agaatctagt tgtataggct aaaagattga attagcatta atctttatgt     4380

gttttgcacc tgaataccta tacctacctt ttaggtagct gcatggaaag atgatgatgg     4440

agattggtac gagactgggt tgcacatatt ctgtaagttt gactcctcaa gaatgcatac     4500

tttaatcttc taatacaaca gtttctttca agatctcttt tctctattaa tcagatagat     4560

atcgctgttt gtgttttgtc ttttgcaaat agccaatttt tgtcagtcga tctgtattct     4620

gccttgccta tcttttttta tctgttaatt tcatatggtg actcatacaa gttggtgcat     4680

cccctttaag ttggggctta cccaaatatg cagaacctgt ttggagaact agggattaac     4740

gatcggttgc agtggaagga acattcgatg atatttgcga tgcctaacaa gccgggggag     4800

ttcagccgct ttgattttcc tgaagctctt cctgcgccat taaatggtta gtacttaatc     4860

atgatttctc ccttctgcat tgattatcca ataaggtatg aaattgatta gtccattgac     4920

cattaatact ctggcacatt gctaacatca aaagaacata aaggttcatt atgtcttgat     4980

cagaatttct gcatgtagct aaagtgattg agtgtctgtg tatattttta tacattgcaa     5040

gcataagcca gttatgttat ctcttatttt catttctcta tcgatgcgtt attacttcta     5100

caggaatttt agccatacta aagaacaacg aaatgcttac atggcccgaa aaaatcaaat     5160

ttgctattgg actcttgcca gcaatgcttg gagggcaatc ttatgttgaa gctcaagacg     5220

gtttaagtgt taaggactgg atgagaaagc aagtatgtga tcgttttatc ttattcttta     5280

aagttcataa ccttgaggac atagttgact tgcatgttgt tgatttaaca tgttnatgtg     5340

atcgttttat cttactcttt aaagttcata accttgagga catagttgac ttgcatgttg     5400

ttgatttaac atgttagaat tgtctacctg cctttctttt tttaacaaca tacatcttac     5460

aaatctcagc agcagctatt tgcttaattg cttttcaggg tgtgcctgat agggtgacag     5520

atgaggtgtt cattgccatg tcaaaggcac ttaacttcat aaaccctgac gagctttcga     5580

tgcagtgcat tttgattgct ttgaacagat ttcttcaggt tagaatcctg atccaccctc     5640

aaaacaaaaa gagagaaagg gatataatcc gaccaagctg taaatcatgt tagggacctg     5700

acatattggt gcaggaaact tatttgtgaa cttttccact ctgtttaact tttctgatat     5760

atttgaatta ttaatctgca ggagaaacat ggttcaaaaa tggccttttt agatggtaat     5820

cctcctgaga gactttgcat gccaattgtt gaacatattg agtcaaaagg tggccaagtc     5880

agactaaact cacgaataaa aaagattgag ctgaatgagg atggaagtgt caaatgtttt     5940

atactgaata atggcagtac aattaaagga gatgcttttg tgtttgccac tccaggtata     6000

atatccatta tactagtatc gatgcttcca gttttcacat ttttaatatg aatgtataat     6060

tttttgctga cttttcatta tccgattagt ggatatcttc aagcttcttt tgcctgaaga     6120

ctggaaagag atcccatatt tccaaaagtt ggagaagcta gtgggagttc ctgtgataaa     6180

tgtccatata tggttagtga tgaaaatttt gcttttcagt gtttggtctt cctctagcat     6240

atctatgtat gtgcatgtta atgnactttt cagtgtttgt tcttcctcta gcatatctat     6300

gtatgtgcct gttaatgtct atacatacat gtttatgtgg tcctccggta ttgtgttaac     6360

ttcccttgag cgaggaactt atggatctac gcttttccaa aactttgatt gcacacattg     6420

caattgtctg ttcaactttg atgagcagaa ctaccattgt ttagctatta gtggctgaga     6480

ttcctgctga aaagatttgt ataaatttaa ttgcaggttt gacagaaaac tgaagaacac     6540

atctgataat ctgctcttca gcaggttcat ttttgatcaa ttttattgtt ccagagcagt     6600

ttctgcgtgt ccatgactac attctcatat tagctccccc cccccnnnnn nnnnnnnnnn     6660

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     6720

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     6780

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     6840

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     6900

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     6960

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7020

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7080

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7140

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7200

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7260

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7320

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7380

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7440

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7500

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     7560

nnnnnnnnnn nnnnnnacat gttatgatga ccatttctcc aaggcatttt atccatgcca     7620

cgtttcatca gctacatgtt gactatgttc ccctactttt taaatggcac cattgttggt     7680

ggagaaagat tatagatgtt cctgatactt gtatgggttc ccttgctcaa tctctctttt     7740

acttcatgca gaagcccatt gctcagtgtg tatgctgaca tgtctgttac atgtaaggta     7800

ttgactcgtc tgtaccattc atactggtct aatctgttgg atatgagttg ctggtaaatt     7860

gcataatgct tgttggattt gtgtgtgagt tgctgctaga tctgtgtcct gctatattta     7920

tgtatgagtt gctgctattg taatcttcat ttaggatgct taatgatata ggttctgtat     7980

gtatggaata gtcaggacaa tgctcctgtc tgtgcacagg ggctctacag gaagcaactt     8040

tcgaaggaga agtaaagaaa gtgtgatgaa cagggaaagt agtttccttt agctacctta     8100

attcagtgtt acctgcaatg ttcagtgttt ggagagaggc gataagccta cttcttaatt     8160

ttgttagaaa atgcgtacaa aatataaatc agtagttact aaaaagttgg agaagtagtg     8220

ggatcttttc gctattttta acccagaata agacagctat gccatatagc tttgattatc     8280

cgttaacgtt ctgtatataa atagataatt cataataatg tcgtaatact aaagcctgga     8340

gatcagactg ctttaactat cctgagatga ttacttttac tcttggatta gcttaggcga     8400

gccacaagac tacattgaat ctttagaaat gagaacataa aaagggtgca gaagtgggga     8460

agtggctgaa cgatatgcat atgggagtga gtggggagta aaattatttc ctttacttgg     8520

gtacaatcaa gaatgaatga caacttagcc cactatatcc gttcatgtgt tctttagggc     8580

cctctgatat aattggtctc tctgcaggaa tattacaacc ccaatcagtc tatgttggaa     8640

ttggtatttg cacctgcaga agagtggata aatcgtagtg actcagaaat tattgatgct     8700

acaatgaagg aactagcaaa gcttttccct gacgaaattt cggcagatca gagcaaagca     8760

aaaatattga agtatcatgt tgtcaaaact ccaaggccag taatcatttg ctttcatact     8820

tgtgcaatat acgagaactg cagtccacgt ggaatctatt cctattctga atcctgatta     8880

atctgctttt tttctctcag gtctgtttat aaaactgtgc caggttgtga accctgtcgg     8940

cccttgcaaa gatctcctat tgaggggttt tatttagctg gcgactacac aaaacagaaa     9000

tacttggctt caatggaagg tgctgtctta tcaggaaagc tttgtgccca agctattgta     9060

caggttagtt ctcacagttg tttttgtcca ctaatagtat atttgatcaa attttgtcat     9120

ctttgctgcg gtagagaatt tttgaagcat ggacgtcaag catgcctctt acttataatt     9180

gctaatttgc ggaatagttc tccaaccaat atagtgttaa accaaaaaaa taaaattgtg     9240

cacacagatc acagagttgc tcaggatatc tgcatttttg gagcctcagt agtagcatga     9300

taaaatgcag aaggttatgt ttttttcatt ctttattaaa tttatatctc tatattttgc     9360

aggattacga gttacttctt ggccggagcc agaagaagtt ggcagaagca agcgtagttt     9420

agcatggtga actaaaatgt tgcttctcta cactaaattt aagatgaagg tggccacact     9480

gaattagcgt tgtagacaac acatacaagg acagtacaac atttaaccca aatacgagaa     9540

atgttacaca aatatgtgct ctgctttccc tccgatttag ttcgcaagtt actaattata     9600

agatggaatt gaatgaaacc aaagacggat aaagacccta aactataaga taagtaagcc     9660

tctccagacc atacaagtgc gcgtcgagcc catgcgaagg gtttggttaa gatatgccag     9720

attccaccaa gtatacaaat gaaacctaac catacatgtc ctccgattat ataatgcaaa     9780

ttgattcatt caaactaaac ttttaagcgt cacagttata ctagcaaata cctttaagac     9840

attaagcttc acgtcttaaa acatcaaaaa ccgcttttag agtaagtatc caactgaacc     9900

atgcaaaaca caaaactgaa acaaagaaca aatggaacta ctaaaagaga caattaaaaa     9960

ttttaatttg gtaaactgtt aaaacgtgtt tgcaagtatg agattttttt ctacaacccc    10020

aagaaaactc tgtcgctaca gcctttgcct tttgagcgag cactctgtac ccattgggta    10080

aacttcttac cgtgtaatag cttgcaaacc acacatgaat ataaaccgca ctaggcaagc    10140

aatgtgcgac agactcaacc cagaaagcat tgaaggggga ttaatcccaa atcatctgta    10200

tggatgaccg ctcttcaaac caaatggcca tcccaaaggg attgaaagta tcggatagta    10260

atgaaccaat cagaaccaca caaaaaagaa gataaatgct gaatttggag cgatggctga    10320

atgcattggg attactttaa aaaatatttg gattttctgt gtacaactta atatttaagc    10380

aaactagatc atataatatg tactactact atgtatcatt agtcaacagc tgctcactta    10440

cagaaatagg atcaggtagc ttttgttata ctctattgca catacactgt attcagataa    10500

gaaatgcaaa tagatgtacg aaacaatcta cgcaaaagga atgttcttag aaaaaagaaa    10560

ggctctcccc aatacttatc gtatcttccc tctgttggtt cactgaatgt gtactgtggt    10620

tttactatac cctttttcct attgcagcat cattttcttc tcgaaaaatt cctccaattt    10680

ctagggaatt gctacttttc ccctaccaat aatttatgta catcgtcaag gctcaaagag    10740

caagagatta tgcatatcta catagcttct catatgtcca atacatttgt atttctgctt    10800

cttagtccta cttggcagcc ctgagcacga aagcatttcg catgcaagca gggtggggag    10860

aaaagctgca ctcaagaagg tttgatgtag gtaacttatt g                        10901


<210>  157
<211>  2804
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  157
tcataaaatt gataaggaga atccatacaa gaaatcgatc gaattatcat tgaaatccat       60

tcaactaaca tcacacttgc tggaagataa taacgatctg cgtaaaaacg agatattcgc      120

tattattcaa gctttggcac atcaatgcat caatccgtgt aagcagataa gtgaatttgc      180

agtggtaacg ctagagcaga cgctcatcaa taaaatcgaa attccaacta atgagatgga      240

atcggtagaa gaattaattg agggcggatt actaccgttg ctaaattcga gtgaaacaca      300

ggaagaccag aaaatcctca tttcatccat attaacaata atttcaaatg tttatttgca      360

ttatttgaaa ctagggaaga caagcaacga aacgtttttg aaaattttga gtattttcaa      420

taaatttgta gaggactcag atattgaaaa aaagctacag caattaatac ttgataagaa      480

gagtattgag aagggcaacg gttcatcatc tcatggatct gcacatgaac aaacaccaga      540

gtcaaacgac gttgaaattg aggctactgc gccaattgat gacaatacag acgatgataa      600

caaaccgaag ttatctgatg tagaaaagga ttaaagatgc taagagatag tgatgatatt      660

tcataaataa tgtaattcta tatatgttaa ttaccttttt tgcgaggcat atttatggtg      720

aaggataagt tttgaccatc aaagaaggtt aatgtggctg tggtttcagg gtccataaag      780

cttttcaatt catctttttt ttttttgttc ttttttttga ttccggtttc tttgaaattt      840

ttttgattcg gtaatctccg agcagaagga agaacgaagg aaggagcaca gacttagatt      900

ggtatatata cgcatatgtg gtgttgaaga aacatgaaat tgcccagtat tcttaaccca      960

actgcacaga acaaaaacct gcaggaaacg aagataaatc atgtcgaaag ctacatataa     1020

ggaacgtgct gctactcatc ctagtcctgt tgctgccaag ctatttaata tcatgcacga     1080

aaagcaaaca aacttgtgtg cttcattgga tgttcgtacc accaaggaat tactggagtt     1140

agttgaagca ttaggtccca aaatttgttt actaaaaaca catgtggata tcttgactga     1200

tttttccatg gagggcacag ttaagccgct aaaggcatta tccgccaagt acaatttttt     1260

actcttcgaa gacagaaaat ttgctgacat tggtaataca gtcaaattgc agtactctgc     1320

gggtgtatac agaatagcag aatgggcaga cattacgaat gcacacggtg tggtgggccc     1380

aggtattgtt agcggtttga agcaggcggc ggaagaagta acaaaggaac ctagaggcct     1440

tttgatgtta gcagaattgt catgcaaggg ctccctagct actggagaat atactaaggg     1500

tactgttgac attgcgaaga gcgacaaaga ttttgttatc ggctttattg ctcaaagaga     1560

catgggtgga agagatgaag gttacgattg gttgattatg acacccggtg tgggtttaga     1620

tgacaaggga gacgcattgg gtcaacagta tagaaccgtg gatgatgtgg tctctacagg     1680

atctgacatt attattgttg gaagaggact atttgcaaag ggaagggatg ctaaggtaga     1740

gggtgaacgt tacagaaaag caggctggga agcatatttg agaagatgcg gccagcaaaa     1800

ctaaaaaact gtattataag taaatgcatg tatactaaac tcacaaatta gagcttcaat     1860

ttaattatat cagttattac ccgggaatct cggtcgtaat gatttctata atgacgaaaa     1920

aaaaaaaatt ggaaagaaaa agcttcatgg cctttataaa aaggaactat ccaatacctc     1980

gccagaacca agtaacagta ttttacgggg cacaaatcaa gaacaataag acaggactgt     2040

aaagatggac gcattgaact ccaaagaaca acaagagttc caaaaagtag tggaacaaaa     2100

gcaaatgaag gatttcatgc gtttgtactc taatctggta gaaagatgtt tcacagactg     2160

tgtcaatgac ttcacaacat caaagctaac caataaggaa caaacatgca tcatgaagtg     2220

ctcagaaaag ttcttgaagc atagcgaacg tgtagggcag cgtttccaag aacaaaacgc     2280

tgccttggga caaggcttgg gccgataagg tgtactggcg tatatatatc taattatgta     2340

tctctggtgt agcccatttt tagcatgtaa atataaagag aaaccatatc taatctaacc     2400

aaatccaaac aaaattcaat agttactatc gcttttttct ttctgtatcg caaataagtg     2460

aaaattaaaa aagaaagatt aaattggaag ttggatatgg gctggaacag cagcagtaat     2520

cggtatcggg ttcgccacta atgacgtcct acgattgcac tcaacagacc ttgacgctca     2580

cgccgtagcg ggcgacaagt caaacggaac aaccgttgcc gttcccatcg gagtccgacc     2640

taggccgaac tccgtgaatt tctgataaca acggtcggta aagactggtt ccccagtata     2700

tttcttctct caggagcagg ggccaatgcc aaaagcgaca ttaacccgga ggacaaggct     2760

ccactgtgtt ccaccgaatt tcccacctga taatatctga taac                      2804


<210>  158
<211>  7411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3116 Full Plasmid Sequence

<400>  158
cccaccggaa ggagctgact gggttgaagg ctctcaaggg catcggtcga gatcccggtg       60

cctaatgagt gagctaactt acattaattg cgttgcgccc cgggatgaga ttatcaaaaa      120

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat      180

atgtgtaaca ttggtctagt gattggatcc ttgacagcta gctcagtcct aggtactgtg      240

ctagcgctag caaagaggag aaaggtacca tgcccgatcg agctcaagtt atcattcgca      300

ttgtgccggg aggtggcacc aagacccttc aacaaattat caatcagttg gagtatctat      360

cccggaaggg caggctggag ctgcagcgtt cagcccgaca tctcgatatt cccctgccac      420

cggatcaaat ccacgaactt gcccgaagct gggttcaaga gactggaact tatgacgaaa      480

gtcagccaga cgaggaaagg caacaggagt tgaccaccca tattattgta agcttccccg      540

ccggtacaag ccaggtagcg gcttatgcgg cgagccggga gtgggcagcc gagatgtttg      600

ggtcaggcgc aggggggggc cgatacaact atcttacggc cttccacatc gatcgcgacc      660

acccacatct gcatgtcgtc gtcaatcggc gcgaactttt aggacacggc tggctgaaga      720

tatctcggcg ccatccccaa ctgaattacg acgccctgcg cataaagatg gccgagattt      780

cacttcgtca tggcattgcc ctcgatgcga gccgacgagc agaacgtggc atcaccgagc      840

ggccgatcac ttatgcccaa tatcggcgcc ttgagcggga gcaggctcgc caaatccgtt      900

tcgaagacgc ggatttggaa cagtcgtcgc cgcaaggaga tcatccagaa ttcagccaac      960

ctttcgatac atccccattt gaagcatccg cgggcggacc ggaggacatg cctcggccca     1020

acaatcggca gaatgagtcg caagttcatc tccaggagcc agctggtgtc agcaacgaag     1080

ccggtgtcct tgtgcgggtt gcattggaaa cggagcgcct tgctcaacca ttcgtttccg     1140

aaaccattct cgcggacgac atagggagcg gctcttcgcg tgttgccgag ggccgtgtgg     1200

agagcgcaaa ccgcactccc gatattcctc gcgcagcaac tgaagctgcc acgcacacga     1260

cacacgaccg gcagcggcgt gcaaagcgtc ctcatgatga cgacggaggg ccgagtggag     1320

caaaacgtgt gacattggaa ggcatcgcgg ttgggcccca ggcgaacgcc ggcgaacagg     1380

atggcagtag tggcccctta gtacggcaag ctggaacgtc acggccatct ccaccgacgg     1440

ccacgacgcg ggccagcacc gcaaccgatt cattgtctgc tacagcccac ctccagcaac     1500

ggagaggtgt cctttcaaag cgtccgcgtg aagatgatga tggagaaccg agtgaacgca     1560

aacgcgagag agatgagcgc agcaaggacg ggcgtggggg aaataggaga agcggtggct     1620

cctcgggtgg cagcatgagc ggatcaaaaa aaagaaggat caagcaagat ccgccgccag     1680

cgctgccgcc caagcgccgt cgctccggcg gtagcagcgg tggttccccg ccgccggctc     1740

tgccgccgaa gcgccgtaga agcggcggtt caagcggtgg ctctccgcca ccggcactgc     1800

ctccgaaacg tcgtcgttct ggcggtagca gcggtggctc gccgccgccg gcgttgccgc     1860

cgaaacgccg tcgttccggt ggcagttccg gtggcagcag tgcgtcgtta gcaagaggcg     1920

gtccaaatgc agtgggactc ctaacgacga acgaaagctt tgagaaaaat atcaatgagg     1980

tctacaaccg tacgcgagcc gagctagacg cttcttcacg tgacagaagt cgctctggac     2040

tatcgcgata atctagacca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc     2100

ctttcgtttt atctgttgtt tgtcggtgaa cgctctctac tagagtcaca ctggctcacc     2160

ttcgggtggg cctttctgcg tttatagtac gatatcccaa tggcgcgccg agcttggctc     2220

gagcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca     2280

tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat     2340

taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt     2400

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctgt tccgcttcct     2460

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     2520

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     2580

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     2640

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     2700

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     2760

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     2820

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     2880

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     2940

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     3000

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     3060

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     3120

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     3180

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     3240

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     3300

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     3360

gtatatatga gtaaacttgg tctgacagtt agaaaaactc atcgagcatc aaatgaaact     3420

gcaatttatt catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg     3480

aaggagaaaa ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga     3540

ttccgactcg tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat     3600

caagtgagaa atcaccatga gtgacgactg aatccggtga gaatggcaaa agtttatgca     3660

tttctttcca gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat     3720

caaccaaacc gttattcatt cgtgattgcg cctgagcgaa acgaaatacg cgatcgctgt     3780

taaaaggaca attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat     3840

caacaatatt ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccag     3900

ggatcgcagt ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg     3960

gaagaggcat aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg     4020

caacgctacc tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc     4080

gatagattgt cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat     4140

cagcatccat gttggaattt aatcgcggcc tagagcaaga cgtttcccgt tgaatatggc     4200

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg     4260

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     4320

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata     4380

ggcgtatcac gaggcccttt tgtctcgcgc gtttcggtga tgacggtgaa aacctctgac     4440

acatgcagct cccggagact gtcacagctt gtctgtaagc ggatgccggg agcagacaag     4500

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat     4560

cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa     4620

ggagaaaata ccgcatcagg cgccattcgc cattcaggct gcgcaactgt tgggaagggc     4680

gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc     4740

gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg acggccagtg     4800

aattgacgcg ttgcggctgc atgaaatcct ggccggtttg tctgatgcca agctggcggc     4860

ctggccggcc agcttggccg ctgaagaaac cgagcgccgc cgtctaaaaa ggtgatgtgt     4920

atttgagtaa aacagcttgc gtcatgcggt cgctgcgtat atgatgcgat gagtaaataa     4980

acaaatacgc aaggggaacg catgaaggtt atcgctgtac ttaaccagaa aggcgggtca     5040

ggcaagacga ccatcgcaac ccatctagcc cgcgccctgc aactcgccgg ggccgatgtt     5100

ctgttagtcg attccgatcc ccagggcagt gcccgcgatt gggcggccgt gcgggaagat     5160

caaccgctaa ccgttgtcgg catcgaccgc ccgacgattg accgcgacgt gaaggccatc     5220

ggccggcgcg acttcgtagt gatcgacgga gcgccccagg cggcggactt ggctgtgtcc     5280

gcgatcaagg cagccgactt cgtgctgatt ccggtgcagc caagccctta cgacatatgg     5340

gccaccgccg acctggtgga gctggttaag cagcgcattg aggtcacgga tggaaggcta     5400

caagcggcct ttgtcgtgtc gcgggcgatc aaaggcacgc gcatcggcgg tgaggttgcc     5460

gaggcgctgg ccgggtacga gctgcccatt cttgagtccc gtatcacgca gcgcgtgagc     5520

tacccaggca ctgccgccgc cggcacaacc gttcttgaat cagaacccga gggcgacgct     5580

gcccgcgagg tccaggcgct ggccgctgaa attaaatcaa aactcatttg agttaatgag     5640

gtaaagagaa aatgagcaaa agcacaaaca cgctaagtgc cggccgtccg agcgcacgca     5700

gcagcaaggc tgcaacgttg gccagcctgg cagacacgcc agccatgaag cgggtcaact     5760

ttcagttgcc ggcggaggat cacaccaagc tgaagatgta cgcggtacgc caaggcaaga     5820

ccattaccga gctgctatct gaatacatcg cgcagctacc agagtaaatg agcaaatgaa     5880

taaatgagta gatgaatttt agcggctaaa ggaggcggca tggaaaatca agaacaacca     5940

ggcaccgacg ccgtggaatg ccccatgtgt ggaggaacgg gcggttggcc aggcgtaagc     6000

ggctgggttg tctgccggcc ctgcaatggc actggaaccc ccaagcccga ggaatcggcg     6060

tgagcggtcg caaaccatcc ggcccggtac aaatcggcgc ggcgctgggt gatgacctgg     6120

tggagaagtt gaaggccgcg caggccgccc agcggcaacg catcgaggca gaagcacgcc     6180

ccggtgaatc gtggcaagcg gccgctgatc gaatccgcaa agaatcccgg caaccgccgg     6240

cagccggtgc gccgtcgatt aggaagccgc ccaagggcga cgagcaacca gattttttcg     6300

ttccgatgct ctatgacgtg ggcacccgcg atagtcgcag catcatggac gtggccgttt     6360

tccgtctgtc gaagcgtgac cgacgagctg gcgaggtgat ccgctacgag cttccagacg     6420

ggcacgtaga ggtttccgca gggccggccg gcatggccag tgtgtgggat tacgacctgg     6480

tactgatggc ggtttcccat ctaaccgaat ccatgaaccg ataccgggaa gggaagggag     6540

acaagcccgg ccgcgtgttc cgtccacacg ttgcggacgt actcaagttc tgccggcgag     6600

ccgatggcgg aaagcagaaa gacgacctgg tagaaacctg cattcggtta aacaccacgc     6660

acgttgccat gcagcgtacg aagaaggcca agaacggccg cctggtgacg gtatccgagg     6720

gtgaagcctt gattagccgc tacaagatcg taaagagcga aaccgggcgg ccggagtaca     6780

tcgagatcga gctagctgat tggatgtacc gcgagatcac agaaggcaag aacccggacg     6840

tgctgacggt tcaccccgat tactttttga tcgatcccgg catcggccgt tttctctacc     6900

gcctggcacg ccgcgccgca ggcaaggcag aagccagatg gttgttcaag acgatctacg     6960

aacgcagtgg cagcgccgga gagttcaaga agttctgttt caccgtgcgc aagctgatcg     7020

ggtcaaatga cctgccggag tacgatttga aggaggaggc ggggcaggct ggcccgatcc     7080

tagtcatgcg ctaccgcaac ctgatcgagg gcgaagcatc cgccggttcc taatgtacgg     7140

agcagatgct agggcaaatt gccctagcag gggaaaaagg tcgaaaaggt ctctttcctg     7200

tggatagcac gtacattggg aacccaaagc cgtacattgg gaaccggaac ccgtacattg     7260

ggaacccaaa gccgtacatt gggaaccggt cacacatgta agtgactgat ataaaagaga     7320

aaaaaggcga tttttccgcc taaaactctt taaaacttat taaaactctt aaaacccgcc     7380

tggcctgtgc atatgctagt catgccccgc g                                    7411


<210>  159
<211>  19324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3098 Full Plasmid Sequence

<400>  159
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cgtccaagct ggagaagttt acaaactgtt acagcctctc caaaaccctc aggtttaaag     9780

cgatcccggt gggcaagacc caggagaaca tcgacaacaa gaggctcctg gtggaagacg     9840

agaagcgcgc cgaagactac aagggcgtga agaagctgct cgataggtac tacctcagct     9900

ttattaacga cgtgctgcac agcatcaaac tcaagaatct caacaactac atctccctct     9960

tccgcaaaaa gacccgcacc gagaaggaga acaaggagct ggagaacctg gagatcaacc    10020

tccgcaagga aatcgccaaa gcgttcaagg gcaatgaagg gtacaagagc ctcttcaaga    10080

aagacatcat cgaaactatc ctcccagagt ttctcgatga caaggacgag atcgcgctgg    10140

tgaactcctt taacgggttc acaaccgcgt ttaccggctt ctttgataac agggaaaata    10200

tgttctccga ggaggccaag tccaccagca tcgccttcag gtgtatcaac gagaacctca    10260

cccgctacat ttccaatatg gacattttcg agaaggtgga tgcgatcttc gataagcacg    10320

aggtgcagga gatcaaagag aagattctca attccgatta tgacgtcgag gatttcttcg    10380

aaggggagtt ctttaatttt gtgctcacac aagagggcat tgacgtgtac aacgcgatta    10440

tcgggggctt cgtcacagag tccggggaga agattaaggg gctgaatgag tacatcaatc    10500

tgtacaatca gaagaccaag cagaaactgc cgaaattcaa gccgctctac aagcaagtcc    10560

tgtccgatag ggaaagcctc tccttctacg gcgagggcta taccagcgac gaggaggtgc    10620

tggaagtctt ccgcaacaca ctgaataaga atagcgagat tttctcctcc atcaagaagc    10680

tcgagaagct ctttaagaac tttgacgagt acagctccgc cgggattttc gtgaagaacg    10740

ggccggcgat cagcaccatc tccaaggaca tctttggcga gtggaacgtc atcagggaca    10800

agtggaacgc cgagtacgac gacatccacc tgaagaagaa ggcggtggtg accgagaagt    10860

atgaggacga tcgcaggaag tccttcaaaa aaatcggctc cttcagcctc gaacagctcc    10920

aggagtatgc cgatgcggat ctgtccgtcg tcgagaagct gaaggaaatc atcattcaga    10980

aggtcgacga gatctataaa gtgtacgggt ccagcgagaa gctgttcgac gccgactttg    11040

tgctcgagaa gtccctcaaa aagaatgacg ccgtggtggc cattatgaaa gacctgctcg    11100

actccgtgaa gtccttcgaa aattacatta aagcgttctt tggggagggg aaggaaacta    11160

acagggatga gtccttctat ggcgactttg tcctcgcgta cgacatcctg ctgaaggtcg    11220

accacattta cgacgcgatc cgcaactacg tgacacagaa gccgtactcc aaagacaagt    11280

tcaagctgta cttccagaac ccgcaattta tggggggctg ggacaaggat aaagagacag    11340

actaccgcgc gacaattctc cgctatggct ccaaatacta tctggccatc atggacaaga    11400

agtacgcgaa gtgcctgcag aagatcgaca aagacgacgt caatggcaac tatgaaaaga    11460

tcaactacaa gctgctgccg ggtccgaaca agatgctccc gaaggtgttc ttcagcaaga    11520

agtggatggc ctactacaat ccaagcgagg atattcagaa aatctataaa aacgggacct    11580

tcaagaaggg ggacatgttt aacctcaacg actgccacaa gctcattgat ttcttcaagg    11640

atagcatttc ccgctacccg aaatggtcca atgcgtacga ttttaacttc tccgagacag    11700

aaaagtacaa agacatcgcg ggcttttaca gggaggtgga ggagcaaggg tataaagttt    11760

cttttgaatc cgcgagcaag aaggaagtcg acaagctcgt cgaggagggc aagctctaca    11820

tgttccaaat ttataacaag gacttttccg acaagagcca tgggacccca aacctccaca    11880

ccatgtactt caaactgctc tttgacgaga acaaccacgg gcaaatcagg ctgagcggcg    11940

gcgccgaatt attcatgcgc agggcctccc tcaagaagga agagctggtc gtccatccag    12000

ccaattcccc gatcgcgaac aagaacccgg acaatccgaa aaagaccacc accctgtcct    12060

acgacgtcta caaggacaaa cgcttcagcg aagaccagta cgaattacac atcccaattg    12120

cgattaataa gtgcccaaag aatatcttca aaattaatac agaggtcagg gtgctgctca    12180

aacacgacga caatccgtat gtcatcggca ttgacagggg cgagcgcaat ctgctctata    12240

tcgtggtcgt ggatgggaag ggcaatattg tggagcagta ctccctgaac gagattatca    12300

acaacttcaa tgggattagg attaagaccg actatcacag cctgctcgac aagaaagaaa    12360

aagagaggtt tgaggcccgc caaaactgga cctccattga gaatatcaaa gaattaaagg    12420

ccggctatat ttcccaagtc gtccacaaga tctgcgagct ggtggagaaa tatgacgccg    12480

tgattgcgct cgaagactta aattctgggt tcaagaactc ccgcgtgaag gtggaaaaac    12540

aggtgtatca gaaattcgag aaaatgctga tcgacaaact caattatatg gtggataaga    12600

agtccaaccc gtgtgccaca gggggcgcgc tgaagggcta tcagatcacc aacaagttcg    12660

agagcttcaa gagcatgagc acccagaacg ggtttatttt ctacatcccg gcgtggctca    12720

cctccaagat tgacccgagc accggcttcg tgaacctcct gaagacaaag tatacctcca    12780

ttgccgacag caagaagttt atctcctcct tcgaccgcat tatgtatgtg ccggaggagg    12840

acctcttcga gttcgccctc gactacaaaa acttcagccg cacagatgcg gattacatca    12900

agaagtggaa gctgtactcc tacgggaaca ggatccgcat cttcaggaat ccaaaaaaaa    12960

ataacgtctt tgactgggag gaagtgtgcc tgacatccgc ctacaaggaa ctgttcaata    13020

aatacggcat caattaccag cagggcgaca ttcgcgccct cctctgtgag cagtccgaca    13080

aagcgtttta ctccagcttc atggccctca tgtccctgat gctccaaatg aggaatagca    13140

tcacagggcg caccgacgtc gacttcctca tcagcccggt gaagaactcc gacgggatct    13200

tttacgactc ccgcaactat gaggcgcaag agaatgcgat cctcccgaag aacgccgatg    13260

cgaacggggc ctataatatc gccaggaaag tgctctgggc catcgggcag ttcaaaaagg    13320

cggaggatga gaagctcgac aaggtgaaaa ttgccatttc caacaaggag tggctggagt    13380

acgcgcagac ctccgtgaag cacggctcct ccgagacacc aggcacctcc gagagcgcga    13440

cgcccgaggg cggctccggc ggctccggca gcgaggaact gctgtccaag aactatcacc    13500

tggagaacga ggttgcaaga ctgaagaagg gatctggctc aggaggctct ggcagcggtg    13560

ggtccggttc agggtctgga ggcagcggtt ccggtgggtc aggatctggt gaggaactgc    13620

tgtctaagaa ctaccatctg gagaacgagg ttgctaggct gaagaagggt agcgggtccg    13680

gaggctcagg atctggtggg agcggatctg gctcaggagg ctctggcagc ggtgggtccg    13740

gttcaggtga agagttgctg agcaagaact accacctgga gaacgaggta gccagactga    13800

agaagggatc tggcagcgga ggctccggat caggtgggtc tggtagcggg tccggaggct    13860

caggctctgg tgggagcgga tctggtgaag agttgttgtc caagaactac catctggaga    13920

acgaggtagc aaggctgaag aagggttcag ggtctggagg cagcggatct ggaggatctg    13980

gatctggcag cggaggctcc ggctcaggtg ggtctggtag cggcgaagag ttgttgtcta    14040

agaactacca cctggagaac gaggtcgcga gactgaagaa gggatctggc tcaggaggct    14100

ctggaagcgg tgggtccggt tcagggtctg gaggcagcgg ctccggtggg tcaggatctg    14160

gagaagagct tttgagcaag aactaccatc tggagaacga ggtcgccagg ctgaagaagg    14220

gtagcgggtc cggaggctca ggatctggtg ggagcggatc tggctcagga ggctctggca    14280

gcggtgggtc cggttcaggc gaagagttgc tttctaagaa ctaccacctg gagaacgagg    14340

tagcgagact gaagaaggga tctggcagcg gaggctccgg atcaggtggg tctggtagcg    14400

ggtccggagg ctcaggctct ggtgggagcg gatctggaga agagctgctg tctaagaact    14460

atcatctgga gaatgaggtt gcaaggctga agaagtgaaa gggctctctg tcatgatttc    14520

atactttcat tattgagctc tgtaattaca attatgacca tgagaacatc tcttattgtg    14580

tggcctttta attgctgatg ttagtactga accaaagctt atcgtgatga tgtaaaagca    14640

ataagtactt gtttgtagct tctttgtgtc tccctttggg cttaatacat ctgtttagtg    14700

ttgtggcttt ggcatagact tctcttggta ataatgcctt gcaatgcaaa atttcaatta    14760

tcaaattcta ttatgttctc accttatggt aacagcttac cctgtggaag atgagattct    14820

tgagttgagt cattgccaat ttttggcatt agcttttgaa ttagtgaatt ttgacaaaaa    14880

ttaccgtgac actgattttg ttgaagctct taagtgtagt ttttacaaaa tttcagtggc    14940

tcgttgtgat tatgtcaaac tcacggcgaa tgtagttctt acagaatttc agtggctccc    15000

tgcaggatcc caatggcgcg cctagctaac tagctagcca cgtgactcgc agaacgttgt    15060

gtggcgagac ggaaagaaag tcacgcctcc aaagagtgca gcatctcttc tggctctcac    15120

ggtcctctgt ggatccatcg atatcgaatt cctgcaggct cgaggtcatt catatgcttg    15180

agaagagagt cgggatagtc caaaataaaa caaaggtaag attacctggt caaaagtgaa    15240

aacatcagtt aaaaggtggt ataaagtaaa atatcggtaa taaaaggtgg cccaaagtga    15300

aatttactct tttctactat tataaaaatt gaggatgttt ttgtcggtac tttgatacgt    15360

catttttgta tgaattggtt tttaagttta ttcgcttttg gaaatgcata tctgtatttg    15420

agtcgggttt taagttcgtt tgcttttgta aatacagagg gatttgtata agaaatatct    15480

ttagaaaaac ccatatgcta atttgacata atttttgaga aaaatatata ttcaggcgaa    15540

ttctcacaat gaacaataat aagattaaaa tagctttccc ccgttgcagc gcatgggtat    15600

tttttctagt aaaaataaaa gataaactta gactcaaaac atttacaaaa acaaccccta    15660

aagttcctaa agcccaaagt gctatccacg atccatagca agcccagccc aacccaaccc    15720

aacccaaccc accccagtcc agccaactgg acaatagtct ccacaccccc ccactatcac    15780

cgtgagttgt ccgcacgcac cgcacgtctc gcagccaaaa aaaaaaagaa agaaaaaaaa    15840

gaaaaagaaa aaacagcagg tgggtccggg tcgtgggggc cggaaacgcg aggaggatcg    15900

cgagccagcg acgaggagct taggcctcat cgttgaagat gcctctgccg acagtggtcc    15960

caaagatgga cccccaccca cgaggagcat cgtggaaaaa gaagacgttc caaccacgtc    16020

ttcaaagcaa gtggattgat gtgatatctc cactgacgta agggatgacg cacaatccca    16080

ctatccttcg aggcctcatc gttgaagatg cctctgccga cagtggtccc aaagatggac    16140

ccccacccac gaggagcatc gtggaaaaag aagacgttcc aaccacgtct tcaaagcaag    16200

tggattgatg tgatatctcc actgacgtaa gggatgacgc acaatcccac tatccttcga    16260

agctccctcc ctccgcttcc aaagaaacgc cccccatcgc cactatatac ataccccccc    16320

ctctcctccc atccccccaa cccttctaga accatcttcc acacactcaa gccacactat    16380

tggagaacac acagggacaa cacaccataa gatccaaggg aggcctccgc cgccgccggt    16440

aaccaccccg cccctctcct ctttctttct ccgttttttt ttccgtctcg gtctcgatct    16500

ttggccttgg tagtttgggt gggcgagagg cggcttcgtg cgcgcccaga tcggtgcgcg    16560

ggaggggcgg gatctcgcgg ctggggctct cgccggcgtg gatccggccc ggatctcgcg    16620

gggaatgggg ctctcggatg tagatctgcg atccgccgtt gttgggggag atgatggggg    16680

gtttaaaatt tccgccgtgc taaacaagat caggaagagg ggaaaagggc actatggttt    16740

atatttttat atatttctgc tgcttcgtca ggcttagatg tgctagatct ttctttcttc    16800

tttttgtggg tagaatttga atccctcagc attgttcatc ggtagttttt cttttcatga    16860

tttgtgacaa atgcagcctc gtgcggagct tttttgtagg tagaaggcgg ccgcatggcc    16920

cagtctaagc acgggttgac gaaggagatg actatgaagt atcgcatgga aggctgcgtt    16980

gacggccaca aattcgtcat taccggcgag ggcatcggct acccctttaa ggtaagtttc    17040

tgcttctacc tttgatatat atataataat tatcattaat tagtagtaat ataatatttc    17100

aaatattttt ttcaaaataa aagaatgtag tatatagcaa ttgcttttct gtagtttata    17160

agtgtgtata ttttaattta taacttttct aatatatgac caaaatttgt tgatgtgcag    17220

ggcaagcaag cgataaacct gtgcgtggtg gagggtggcc ctctgccctt cgccgaggat    17280

atactctcag ccgccttcat gtacgggaat cgggtgttca cggagtaccc gcaagacatc    17340

gtggactact tcaagaactc ctgccccgcc ggatacacat gggaccgttc cttcctcttc    17400

gaggacggag ccgtttgcat ctgcaacgcg gacatcaccg tgtccgtcga ggagaactgc    17460

atgtaccacg agtcaaagtt ctatggagtg aacttcccgg ccgatggtcc cgtgatgaag    17520

aaaatgacgg acaactggga gccgtcgtgc gagaaaatca ttcccgtccc aaaacaggga    17580

atcctcaagg gcgacgtgtc gatgtaccta cttctcaagg acggtggacg gctacggtgc    17640

cagttcgaca ctgtttacaa ggcgaagtcg gtgccgagga agatgccgga ctggcacttt    17700

atccagcaca agctgacaag ggaggacaga agcgacgcta agaaccagaa atggcacctc    17760

accgagcacg ccatcgccag tggctctgcg ctgcccgggt gaccctgcaa tgtgacccta    17820

gacttgtcca tcttctggat tggccaactt aattaatgta tgaaataaaa ggatgcacac    17880

atagtgacat gctaatcact ataatgtggg catcaaagtt gtgtgttatg tgtaattact    17940

aattatctga ataagagaaa gagatcatcc atatttctta tcctaaatga atgtcacgtg    18000

tctttataat tctttgatga accagatgca ttttattaac caattccata tacatataaa    18060

tattaatcat atataattaa tatcaattgg gttagcaaaa caaatctagt ctaggtgtgt    18120

tttgctaatt attgggggat agtgcaaaaa gaaatctacg ttctcaataa ttcagataga    18180

aaacttaata aagtgagata atttacatag attgctttta tcctttgata tatgtgaaac    18240

catgcatgat ataaggaaaa tagatagaga aataattttt tacatcgttg aatatgtaaa    18300

caatttaatt caagaagcta ggaatataaa tattgaggag tttatgatta ttattattat    18360

tttgatgttc aatgaagttt tttttaattt catatgaagt atacaaaaat tcttcataga    18420

tttttgtttc tatgccgtag ttatctttaa tatatttgtg gttgaagaaa tttattgcta    18480

gaaacgaatg gattgtcaat ttttttttaa agcaaatata tatgaaatta tactgtatat    18540

tattttagtc atgattaaaa tgtggcctta attgaatcat ctttctcatt cattttttca    18600

aaagcatatc aggatgattg atatttatct attttaaaaa ttaatttaag ggttcaaatt    18660

aaatttaact taaaagtgtc ctaaccgtag ttaaaggttt actttaaaaa aatactatga    18720

aaaatctaat cttctatgaa tcgagggccc ggccgtgacg gccacgagcg aactcctgca    18780

ggcgataaaa atgttttaaa cgatatatat tataaaaaaa aacgtttcaa aaataaatac    18840

aaaaatgttt ttaaatatat ataatttaac tcattaaaga aaataaaaat gcaagtgcgg    18900

tgacaagaca agctaaaagt tgcaaaagaa atggcagggc tataaggctc acctactcct    18960

ggatttacca aattttggtt cgtccctata ctcgaaaaat aaaacaaaat aaatttcagt    19020

atcttcgttt ttgtatgctt tgactgtgag gcgaggccaa ctttcttctt ctgtctgaga    19080

tgaattttgt ttgcctcctg tgaaggatgt atcattcaaa gtgaatgttt tgcaactgcc    19140

agtagtccca catcgaccaa atattcttat tacagtgtgt ttatatagca cctggagaag    19200

gaatgggttg tttcaaagat taaataattt ctactaagtg tagattgccg ttaatttgag    19260

agtccaagta atttctacta agtgtagatt tttttttgcg gccgcacaac aaacgcgccg    19320

gcga                                                                 19324


<210>  160
<211>  19324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3093 Full Plasmid Sequence

<400>  160
agcttactag tcaacaattg gccaatcttt gttctaaatt gctaataaac gaccatttcc       60

gtcaattctc cttggttgca acagtctacc cgtcaaatgt ttactaattt ataagtgtga      120

agtttgaatt atgaaagacg aaatcgtatt aaaaattcac aagaataaac aactccatag      180

attttcaaaa aaacagtcac gagaaaaaaa ccacagtccg tttgtctgct cttctagttt      240

ttattatttt tctattaata gttttttgtt atttcgagaa taaaatttga acgatgtccg      300

aaccacaaaa gccgagccga taaatcctaa gccgagccta actttagccg taaccatcag      360

tcacggctcc cgggctaatt catttgaacc gaatcataat caacggttta gatcaaactc      420

aaaacaatct aacggcaaca tagacgcgtc ggtgagctaa aaagagtgtg aaagccaggt      480

caccatagca ttgtctctcc cagatttttt atttgggaaa taatagaaga aatagaaaaa      540

aataaaagag tgagaaaaat cgtagagcta tatattcgca catgtactcg tttcgctttc      600

cttagtgtta gctgctgccg ctgttgtttc tcctccattt ctctatcttt ctctctcgct      660

gcttctcgaa tcttctgtat catcttcttc ttcttcaagg tgagtctcta gatccgttcg      720

cttgattttg ctgctcgtta gtcgttattg ttgattctct atgccgattt cgctagatct      780

gtttagcatg cgttgtggtt ttatgagaaa atctttgttt tgggggttgc ttgttatgtg      840

attcgatccg tgcttgttgg atcgatctga gctaattctt aaggtttatg tgttagatct      900

atggagtttg aggattcttc tcgcttctgt cgatctctcg ctgttatttt tgtttttttc      960

agtgaagtga agttgtttag ttcgaaatga cttcgtgtat gctcgattga tctggtttta     1020

atcttcgatc tgttaggtgt tgatgtttac aagtgaattc tagtgttttc tcgttgagat     1080

ctgtgaagtt tgaacctagt tttctcaata atcaacatat gaagcgatgt ttgagtttca     1140

ataaacgctg ctaatcttcg aaactaagtt gtgatctgat tcgtgtttac ttcatgagct     1200

tatccaattc atttcggttt cattttactt tttttttagt gaaccatggc gcaagttagc     1260

agaatctgca atggtgtgca gaacccatct cttatctcca atctctcgaa atccagtcaa     1320

cgcaaatctc ccttatcggt ttctctgaag acgcagcagc atccacgagc ttatccgatt     1380

tcgtcgtcgt ggggattgaa gaagagtggg atgacgttaa ttggctctga gcttcgtcct     1440

cttaaggtca tgtcttctgt ttccacggcg tgcatggggg aagcggtgat cgccgaagta     1500

tcgactcaac tatcagaggt agttggcgtc atcgagcgcc atctcgaacc gacgttgctg     1560

gccgtacatt tgtacggctc cgcagtggat ggcggcctga agccacacag tgatattgat     1620

ttgctggtta cggtgaccgt aaggcttgat gaaacaacgc ggcgagcttt gatcaacgac     1680

cttttggaaa cttcggcttc ccctggagag agcgagattc tccgcgctgt agaagtcacc     1740

attgttgtgc acgacgacat cattccgtgg cgttatccag ctaagcgcga actgcaattt     1800

ggagaatggc agcgcaatga cattcttgca ggtatcttcg agccagccac gatcgacatt     1860

gatctggcta tcttgctgac aaaagcaaga gaacatagcg ttgccttggt aggtccagcg     1920

gcggaggaac tctttgatcc ggttcctgaa caggatctat ttgaggcgct aaatgaaacc     1980

ttaacgctat ggaactcgcc gcccgactgg gctggcgatg agcgaaatgt agtgcttacg     2040

ttgtcccgca tttggtacag cgcagtaacc ggcaaaatcg cgccgaagga tgtcgctgcc     2100

gactgggcaa tggagcgcct gccggcccag tatcagcccg tcatacttga agctagacag     2160

gcttatcttg gacaagaaga agatcgcttg gcctcgcgcg cagatcagtt ggaagaattt     2220

gtccactacg tgaaaggcga gatcaccaag gtagtcggca aataaggatc aattcccgat     2280

cgttcaaaca tttggcaata aagtttctta agattgaatc ctgttgccgg tcttgcgatg     2340

attatcatat aatttctgtt gaattacgtt aagcatgtaa taattaacat gtaatgcatg     2400

acgttattta tgagatgggt ttttatgatt agagtcccgc aattatacat ttaatacgcg     2460

atagaaaaca aaatatagcg cgcaaactag gataaattat cgcgcgcggt gtcatctatg     2520

ttactagatc ggtacctacg cgtagctagc ccgtgaagtt tctcatctaa gcccccattt     2580

ggacgtgaat gtagacacgt cgaaataaag atttccgaat tagaataatt tgtttattgc     2640

tttcgcctat aaatacgacg gatcgtaatt tgtcgtttta tcaaaatgta ctttcatttt     2700

ataataacgc tgcggacatc tacatttttg aattgaaaaa aaattggtaa ttactctttc     2760

tttttctcca tattgaccat catactcatt gctgatccat gtagatttcc cggacatgaa     2820

gccatttaca attgaatata tcctgccgcc gctgccgctt tgcacccggt ggagcttgca     2880

tgttggtttc tacgcagaac tgagccggtt aggcagataa tttccattga gaactgagcc     2940

atgtgcacct tccccccaac acggtgagcg acggggcaac ggagtgatcc acatgggact     3000

tttcctagct tggctgccat ttttggggtg aggccgttcg cggccgaggg gcgcagcccc     3060

tggggggatg ggaggcccgc gttagcgggc cgggagggtt cgagaagggg gggcaccccc     3120

cttcggcgtg cgcggtcacg cgcacagggc gcagccctgg ttaaaaacaa ggtttataaa     3180

tattggttta aaagcaggtt aaaagacagg ttagcggtgg ccgaaaaacg ggcggaaacc     3240

cttgcaaatg ctggattttc tgcctgtgga cagcccctca aatgtcaata ggtgcgcccc     3300

tcatctgtca gcactctgcc cctcaagtgt caaggatcgc gcccctcatc tgtcagtagt     3360

cgcgcccctc aagtgtcaat accgcagggc acttatcccc aggcttgtcc acatcatctg     3420

tgggaaactc gcgtaaaatc aggcgttttc gccgatttgc gaggctggcc agctccacgt     3480

cgccggccga aatcgagcct gcccctcatc tgtcaacgcc gcgccgggtg agtcggcccc     3540

tcaagtgtca acgtccgccc ctcatctgtc agtgagggcc aagttttccg cgaggtatcc     3600

acaacgccgg cggccggccg cggtgtctcg cacacggctt cgacggcgtt tctggcgcgt     3660

ttgcagggcc atagacggcc gccagcccag cggcgagggc aaccagcccg gtgagcgtcg     3720

gaaagggtcg atcgaccgat gcccttgaga gccttcaacc cagtcagctc cttccggtgg     3780

gcgcggggca tgactatcgt cgccgcactt atgactgtct tctttatcat gcaactcgta     3840

ggacaggtgc cggcagcgct ctgggtcatt ttcggcgagg accgctttcg ctggagcgcg     3900

acgatgatcg gcctgtcgct tgcggtattc ggaatcttgc acgccctcgc tcaagccttc     3960

gtcactggtc ccgccaccaa acgtttcggc gagaagcagg ccattatcgc cggcatggcg     4020

gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat ggccttcccc     4080

attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc catgctgtcc     4140

aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc tcttaccagc     4200

ctaacttcga tcattggacc gctgatcgtc acggcgattt atgccgcctc ggcgagcaca     4260

tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct ccccgcgttg     4320

cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg cacctcgcta     4380

acggattcac cactccaaga attggagcca atcaattctt gcggagaact gtgaatgcgc     4440

aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc cgcacgcggc     4500

gcatctcggg cagcgttggg tcctggccac gggtgcgcat gatcgtgctc ctgtcgttga     4560

ggacccggct aggctggcgg ggttgcctta ctggttagca gaatgaatca ccgatacgcg     4620

agcgaacgtg aagcgactgc tgctgcaaaa cgtctgcgac ctgagcaaca acatgaatgg     4680

tcttcggttt ccgtgtttcg taaagtctgg aaacgcggaa gtcagcgccc tgcaccatta     4740

tgttccggat ctgcatcgca ggatgctgct ggctaccctg tggaacacct acatctgtat     4800

taacgaagcg ctggcattga ccctgagtga tttttctctg gtcccgccgc atccataccg     4860

ccagttgttt accctcacaa cgttccagta accgggcatg ttcatcatca gtaacccgta     4920

tcgtgagcat cctctctcgt ttcatcggta tcattacccc catgaacaga aatccccctt     4980

acacggaggc atcagtgacc aaacaggaaa aaaccgccct taacatggcc cgctttatca     5040

gaagccagac attaacgctt ctggagaaac tcaacgagct ggacgcggat gaacaggcag     5100

acatctgtga atcgcttcac gaccacgctg atgagcttta ccgcagctgc ctcgcgcgtt     5160

tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc acagcttgtc     5220

tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt gttggcgggt     5280

gtcggggcgc agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttaacta     5340

tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa taccgcacag     5400

atgcgtaagg agaaaatacc gcatcaggcg ctcttccgct tcctcgctca ctgactcgct     5460

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     5520

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     5580

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5640

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5700

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5760

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5820

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5880

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5940

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     6000

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt     6060

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     6120

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     6180

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     6240

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     6300

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     6360

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     6420

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     6480

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     6540

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6600

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6660

tagtttgcgc aacgttgttg ccattgctgc aggtcgggag cacaggatga cgcctaacaa     6720

ttcattcaag ccgacaccgc ttcgcggcgc ggcttaattc aggagttaaa catcatgagg     6780

gaagcggtga tcgccgaagt atcgactcaa ctatcagagg tagttggcgt catcgagcgc     6840

catctcgaac cgacgttgct ggccgtacat ttgtacggct ccgcagtgga tggcggcctg     6900

aagccacaca gtgatattga tttgctggtt acggtgaccg taaggcttga tgaaacaacg     6960

cggcgagctt tgatcaacga ccttttggaa acttcggctt cccctggaga gagcgagatt     7020

ctccgcgctg tagaagtcac cattgttgtg cacgacgaca tcattccgtg gcgttatcca     7080

gctaagcgcg aactgcaatt tggagaatgg cagcgcaatg acattcttgc aggtatcttc     7140

gagccagcca cgatcgacat tgatctggct atcttgctga caaaagcaag agaacatagc     7200

gttgccttgg taggtccagc ggcggaggaa ctctttgatc cggttcctga acaggatcta     7260

tttgaggcgc taaatgaaac cttaacgcta tggaactcgc cgcccgactg ggctggcgat     7320

gagcgaaatg tagtgcttac gttgtcccgc atttggtaca gcgcagtaac cggcaaaatc     7380

gcgccgaagg atgtcgctgc cgactgggca atggagcgcc tgccggccca gtatcagccc     7440

gtcatacttg aagctaggca ggcttatctt ggacaagaag atcgcttggc ctcgcgcgca     7500

gatcagttgg aagaatttgt tcactacgtg aaaggcgaga tcaccaaggt agtcggcaaa     7560

taatgtctaa caattcgttc aagccgacgc cgcttcgcgg cgcggcttaa ctcaagcgtt     7620

agatgctgca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7680

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7740

cttcggtcct ccgatcgagg atttttcggc gctgcgctac gtccgcgacc gcgttgaggg     7800

atcaagccac agcagcccac tcgaccttct agccgaccca gacgagccaa gggatctttt     7860

tggaatgctg ctccgtcgtc aggctttccg acgtttgggt ggttgaacag aagtcattat     7920

cgcacggaat gccaagcact cccgagggga accctgtggt tggcatgcac atacaaatgg     7980

acgaacggat aaaccttttc acgccctttt aaatatccga ttattctaat aaacgctctt     8040

ttctcttagg tttacccgcc aatatatcct gtcaaacact gatagtttaa actgaaggcg     8100

ggaaacgaca atctggcgcg ccactgttaa taatttttaa acgtcagcgc actaaaaaaa     8160

cgaaaagacg gacacgtgaa aataaaaaac acacactagt ttatgacgca atactatttt     8220

acttatgatt tgggtacatt agacaaaacc gtgaaagaga tgtatcagct atgaaacctg     8280

tatacttcaa tacagagact tactcatatc ggatacgtac gcacgaagta tcatattaat     8340

tattttaatt tttaataaat attttatcgg atacttatgt gatactctac atatacacaa     8400

ggatatttct aagatacttt atagatacgt atcctagaaa aacatgaaga gtaaaaaagt     8460

gagacaatgt tgtaaaaatt cattataaat gtatatgatt caattttaga tatgcatcag     8520

tataattgat tctcgatgaa acacttaaaa ttatatttct tgtggaagaa cgtagcgaga     8580

gaggtgattc agttagacaa cattaaataa aattaatgtt aagttctttt aatgatgttt     8640

ctctcaatat cacatcatat gaaaatgtaa tatgatttat aagaaaattt ttaaaaaatt     8700

tattttaata atcacatgta ctatttttta aaaattgtat cttttataat aatacaataa     8760

taaagagtaa tcagtgttaa tttttcttca aatataagtt ttattataaa tcattgttaa     8820

cgtatcataa gtcattaccg tatcgtatct taattttttt ttaaaaaccg ctaattcacg     8880

tacccgtatt gtattgtacc cgcacctgta tcacaatcga tcttagttag aagaattgtc     8940

tcgaggcggt gcaagacagc atataataga cgtggactct cttataccaa acgttgtcgt     9000

atcacaaagg gttaggtaac aagtcacagt ttgtccacgt gtcacgtttt aattggaaga     9060

ggtgccgttg gcgtaatata acagccaatc gatttttgct ataaaagcaa atcaggtaaa     9120

ctaaacttct tcattctttt cttccccatc gctacaaaac cggttccttt ggaaaagaga     9180

ttcattcaaa cctagcaccc aattccgttt caaggtataa tctactttct attcttcgat     9240

tattttatta ttattagcta ctatcgttta atcgatcttt tcttttgatc cgtcaaattt     9300

aaattcaatt agggttttgt tcttttcttt catctgattg aaatccttct gaattgaacc     9360

gtttacttga ttttactgtt tattgtatga tttaatcctt tgtttttcaa agacagtctt     9420

tagattgtga ttaggggttc atataaattt ttagatttgg atttttgtat tgtatgattc     9480

aaaaaatacg tcctttaatt agattagtac atggatattt tttacccgat ttattgattg     9540

tcagggagaa tttgatgagc aagttttttt gatgtctgtt gtaaattgaa ttgattataa     9600

ttgctgatct gctgcttcca gttttcataa cccatattct tttaaccttg ttgtacacac     9660

aatgaaaaat tggtgattga ttcatttgtt tttctttgtt ttggattata cagggtatgg     9720

cggaggaact gctgtccaag aactatcacc tggagaacga ggttgcaaga ctgaagaagg     9780

gatctggctc aggaggctct ggcagcggtg ggtccggttc agggtctgga ggcagcggtt     9840

ccggtgggtc aggatctggt gaggaactgc tgtctaagaa ctaccatctg gagaacgagg     9900

ttgctaggct gaagaagggt agcgggtccg gaggctcagg atctggtggg agcggatctg     9960

gctcaggagg ctctggcagc ggtgggtccg gttcaggtga agagttgctg agcaagaact    10020

accacctgga gaacgaggta gccagactga agaagggatc tggcagcgga ggctccggat    10080

caggtgggtc tggtagcggg tccggaggct caggctctgg tgggagcgga tctggtgaag    10140

agttgttgtc caagaactac catctggaga acgaggtagc aaggctgaag aagggttcag    10200

ggtctggagg cagcggatct ggaggatctg gatctggcag cggaggctcc ggctcaggtg    10260

ggtctggtag cggcgaagag ttgttgtcta agaactacca cctggagaac gaggtcgcga    10320

gactgaagaa gggatctggc tcaggaggct ctggaagcgg tgggtccggt tcagggtctg    10380

gaggcagcgg ctccggtggg tcaggatctg gagaagagct tttgagcaag aactaccatc    10440

tggagaacga ggtcgccagg ctgaagaagg gtagcgggtc cggaggctca ggatctggtg    10500

ggagcggatc tggctcagga ggctctggca gcggtgggtc cggttcaggc gaagagttgc    10560

tttctaagaa ctaccacctg gagaacgagg tagcgagact gaagaaggga tctggcagcg    10620

gaggctccgg atcaggtggg tctggtagcg ggtccggagg ctcaggctct ggtgggagcg    10680

gatctggaga agagctgctg tctaagaact atcatctgga gaatgaggtt gcaaggctga    10740

agaagggctc ctccgagaca ccaggcacct ccgagagcgc gacgcccgag ggcggctccg    10800

gcggctccgg cagctccaag ctggagaagt ttacaaactg ttacagcctc tccaaaaccc    10860

tcaggtttaa agcgatcccg gtgggcaaga cccaggagaa catcgacaac aagaggctcc    10920

tggtggaaga cgagaagcgc gccgaagact acaagggcgt gaagaagctg ctcgataggt    10980

actacctcag ctttattaac gacgtgctgc acagcatcaa actcaagaat ctcaacaact    11040

acatctccct cttccgcaaa aagacccgca ccgagaagga gaacaaggag ctggagaacc    11100

tggagatcaa cctccgcaag gaaatcgcca aagcgttcaa gggcaatgaa gggtacaaga    11160

gcctcttcaa gaaagacatc atcgaaacta tcctcccaga gtttctcgat gacaaggacg    11220

agatcgcgct ggtgaactcc tttaacgggt tcacaaccgc gtttaccggc ttctttgata    11280

acagggaaaa tatgttctcc gaggaggcca agtccaccag catcgccttc aggtgtatca    11340

acgagaacct cacccgctac atttccaata tggacatttt cgagaaggtg gatgcgatct    11400

tcgataagca cgaggtgcag gagatcaaag agaagattct caattccgat tatgacgtcg    11460

aggatttctt cgaaggggag ttctttaatt ttgtgctcac acaagagggc attgacgtgt    11520

acaacgcgat tatcgggggc ttcgtcacag agtccgggga gaagattaag gggctgaatg    11580

agtacatcaa tctgtacaat cagaagacca agcagaaact gccgaaattc aagccgctct    11640

acaagcaagt cctgtccgat agggaaagcc tctccttcta cggcgagggc tataccagcg    11700

acgaggaggt gctggaagtc ttccgcaaca cactgaataa gaatagcgag attttctcct    11760

ccatcaagaa gctcgagaag ctctttaaga actttgacga gtacagctcc gccgggattt    11820

tcgtgaagaa cgggccggcg atcagcacca tctccaagga catctttggc gagtggaacg    11880

tcatcaggga caagtggaac gccgagtacg acgacatcca cctgaagaag aaggcggtgg    11940

tgaccgagaa gtatgaggac gatcgcagga agtccttcaa aaaaatcggc tccttcagcc    12000

tcgaacagct ccaggagtat gccgatgcgg atctgtccgt cgtcgagaag ctgaaggaaa    12060

tcatcattca gaaggtcgac gagatctata aagtgtacgg gtccagcgag aagctgttcg    12120

acgccgactt tgtgctcgag aagtccctca aaaagaatga cgccgtggtg gccattatga    12180

aagacctgct cgactccgtg aagtccttcg aaaattacat taaagcgttc tttggggagg    12240

ggaaggaaac taacagggat gagtccttct atggcgactt tgtcctcgcg tacgacatcc    12300

tgctgaaggt cgaccacatt tacgacgcga tccgcaacta cgtgacacag aagccgtact    12360

ccaaagacaa gttcaagctg tacttccaga acccgcaatt tatggggggc tgggacaagg    12420

ataaagagac agactaccgc gcgacaattc tccgctatgg ctccaaatac tatctggcca    12480

tcatggacaa gaagtacgcg aagtgcctgc agaagatcga caaagacgac gtcaatggca    12540

actatgaaaa gatcaactac aagctgctgc cgggtccgaa caagatgctc ccgaaggtgt    12600

tcttcagcaa gaagtggatg gcctactaca atccaagcga ggatattcag aaaatctata    12660

aaaacgggac cttcaagaag ggggacatgt ttaacctcaa cgactgccac aagctcattg    12720

atttcttcaa ggatagcatt tcccgctacc cgaaatggtc caatgcgtac gattttaact    12780

tctccgagac agaaaagtac aaagacatcg cgggctttta cagggaggtg gaggagcaag    12840

ggtataaagt ttcttttgaa tccgcgagca agaaggaagt cgacaagctc gtcgaggagg    12900

gcaagctcta catgttccaa atttataaca aggacttttc cgacaagagc catgggaccc    12960

caaacctcca caccatgtac ttcaaactgc tctttgacga gaacaaccac gggcaaatca    13020

ggctgagcgg cggcgccgaa ttattcatgc gcagggcctc cctcaagaag gaagagctgg    13080

tcgtccatcc agccaattcc ccgatcgcga acaagaaccc ggacaatccg aaaaagacca    13140

ccaccctgtc ctacgacgtc tacaaggaca aacgcttcag cgaagaccag tacgaattac    13200

acatcccaat tgcgattaat aagtgcccaa agaatatctt caaaattaat acagaggtca    13260

gggtgctgct caaacacgac gacaatccgt atgtcatcgg cattgacagg ggcgagcgca    13320

atctgctcta tatcgtggtc gtggatggga agggcaatat tgtggagcag tactccctga    13380

acgagattat caacaacttc aatgggatta ggattaagac cgactatcac agcctgctcg    13440

acaagaaaga aaaagagagg tttgaggccc gccaaaactg gacctccatt gagaatatca    13500

aagaattaaa ggccggctat atttcccaag tcgtccacaa gatctgcgag ctggtggaga    13560

aatatgacgc cgtgattgcg ctcgaagact taaattctgg gttcaagaac tcccgcgtga    13620

aggtggaaaa acaggtgtat cagaaattcg agaaaatgct gatcgacaaa ctcaattata    13680

tggtggataa gaagtccaac ccgtgtgcca cagggggcgc gctgaagggc tatcagatca    13740

ccaacaagtt cgagagcttc aagagcatga gcacccagaa cgggtttatt ttctacatcc    13800

cggcgtggct cacctccaag attgacccga gcaccggctt cgtgaacctc ctgaagacaa    13860

agtatacctc cattgccgac agcaagaagt ttatctcctc cttcgaccgc attatgtatg    13920

tgccggagga ggacctcttc gagttcgccc tcgactacaa aaacttcagc cgcacagatg    13980

cggattacat caagaagtgg aagctgtact cctacgggaa caggatccgc atcttcagga    14040

atccaaaaaa aaataacgtc tttgactggg aggaagtgtg cctgacatcc gcctacaagg    14100

aactgttcaa taaatacggc atcaattacc agcagggcga cattcgcgcc ctcctctgtg    14160

agcagtccga caaagcgttt tactccagct tcatggccct catgtccctg atgctccaaa    14220

tgaggaatag catcacaggg cgcaccgacg tcgacttcct catcagcccg gtgaagaact    14280

ccgacgggat cttttacgac tcccgcaact atgaggcgca agagaatgcg atcctcccga    14340

agaacgccga tgcgaacggg gcctataata tcgccaggaa agtgctctgg gccatcgggc    14400

agttcaaaaa ggcggaggat gagaagctcg acaaggtgaa aattgccatt tccaacaagg    14460

agtggctgga gtacgcgcag acctccgtga agcactgaaa gggctctctg tcatgatttc    14520

atactttcat tattgagctc tgtaattaca attatgacca tgagaacatc tcttattgtg    14580

tggcctttta attgctgatg ttagtactga accaaagctt atcgtgatga tgtaaaagca    14640

ataagtactt gtttgtagct tctttgtgtc tccctttggg cttaatacat ctgtttagtg    14700

ttgtggcttt ggcatagact tctcttggta ataatgcctt gcaatgcaaa atttcaatta    14760

tcaaattcta ttatgttctc accttatggt aacagcttac cctgtggaag atgagattct    14820

tgagttgagt cattgccaat ttttggcatt agcttttgaa ttagtgaatt ttgacaaaaa    14880

ttaccgtgac actgattttg ttgaagctct taagtgtagt ttttacaaaa tttcagtggc    14940

tcgttgtgat tatgtcaaac tcacggcgaa tgtagttctt acagaatttc agtggctccc    15000

tgcaggatcc caatggcgcg cctagctaac tagctagcca cgtgactcgc agaacgttgt    15060

gtggcgagac ggaaagaaag tcacgcctcc aaagagtgca gcatctcttc tggctctcac    15120

ggtcctctgt ggatccatcg atatcgaatt cctgcaggct cgaggtcatt catatgcttg    15180

agaagagagt cgggatagtc caaaataaaa caaaggtaag attacctggt caaaagtgaa    15240

aacatcagtt aaaaggtggt ataaagtaaa atatcggtaa taaaaggtgg cccaaagtga    15300

aatttactct tttctactat tataaaaatt gaggatgttt ttgtcggtac tttgatacgt    15360

catttttgta tgaattggtt tttaagttta ttcgcttttg gaaatgcata tctgtatttg    15420

agtcgggttt taagttcgtt tgcttttgta aatacagagg gatttgtata agaaatatct    15480

ttagaaaaac ccatatgcta atttgacata atttttgaga aaaatatata ttcaggcgaa    15540

ttctcacaat gaacaataat aagattaaaa tagctttccc ccgttgcagc gcatgggtat    15600

tttttctagt aaaaataaaa gataaactta gactcaaaac atttacaaaa acaaccccta    15660

aagttcctaa agcccaaagt gctatccacg atccatagca agcccagccc aacccaaccc    15720

aacccaaccc accccagtcc agccaactgg acaatagtct ccacaccccc ccactatcac    15780

cgtgagttgt ccgcacgcac cgcacgtctc gcagccaaaa aaaaaaagaa agaaaaaaaa    15840

gaaaaagaaa aaacagcagg tgggtccggg tcgtgggggc cggaaacgcg aggaggatcg    15900

cgagccagcg acgaggagct taggcctcat cgttgaagat gcctctgccg acagtggtcc    15960

caaagatgga cccccaccca cgaggagcat cgtggaaaaa gaagacgttc caaccacgtc    16020

ttcaaagcaa gtggattgat gtgatatctc cactgacgta agggatgacg cacaatccca    16080

ctatccttcg aggcctcatc gttgaagatg cctctgccga cagtggtccc aaagatggac    16140

ccccacccac gaggagcatc gtggaaaaag aagacgttcc aaccacgtct tcaaagcaag    16200

tggattgatg tgatatctcc actgacgtaa gggatgacgc acaatcccac tatccttcga    16260

agctccctcc ctccgcttcc aaagaaacgc cccccatcgc cactatatac ataccccccc    16320

ctctcctccc atccccccaa cccttctaga accatcttcc acacactcaa gccacactat    16380

tggagaacac acagggacaa cacaccataa gatccaaggg aggcctccgc cgccgccggt    16440

aaccaccccg cccctctcct ctttctttct ccgttttttt ttccgtctcg gtctcgatct    16500

ttggccttgg tagtttgggt gggcgagagg cggcttcgtg cgcgcccaga tcggtgcgcg    16560

ggaggggcgg gatctcgcgg ctggggctct cgccggcgtg gatccggccc ggatctcgcg    16620

gggaatgggg ctctcggatg tagatctgcg atccgccgtt gttgggggag atgatggggg    16680

gtttaaaatt tccgccgtgc taaacaagat caggaagagg ggaaaagggc actatggttt    16740

atatttttat atatttctgc tgcttcgtca ggcttagatg tgctagatct ttctttcttc    16800

tttttgtggg tagaatttga atccctcagc attgttcatc ggtagttttt cttttcatga    16860

tttgtgacaa atgcagcctc gtgcggagct tttttgtagg tagaaggcgg ccgcatggcc    16920

cagtctaagc acgggttgac gaaggagatg actatgaagt atcgcatgga aggctgcgtt    16980

gacggccaca aattcgtcat taccggcgag ggcatcggct acccctttaa ggtaagtttc    17040

tgcttctacc tttgatatat atataataat tatcattaat tagtagtaat ataatatttc    17100

aaatattttt ttcaaaataa aagaatgtag tatatagcaa ttgcttttct gtagtttata    17160

agtgtgtata ttttaattta taacttttct aatatatgac caaaatttgt tgatgtgcag    17220

ggcaagcaag cgataaacct gtgcgtggtg gagggtggcc ctctgccctt cgccgaggat    17280

atactctcag ccgccttcat gtacgggaat cgggtgttca cggagtaccc gcaagacatc    17340

gtggactact tcaagaactc ctgccccgcc ggatacacat gggaccgttc cttcctcttc    17400

gaggacggag ccgtttgcat ctgcaacgcg gacatcaccg tgtccgtcga ggagaactgc    17460

atgtaccacg agtcaaagtt ctatggagtg aacttcccgg ccgatggtcc cgtgatgaag    17520

aaaatgacgg acaactggga gccgtcgtgc gagaaaatca ttcccgtccc aaaacaggga    17580

atcctcaagg gcgacgtgtc gatgtaccta cttctcaagg acggtggacg gctacggtgc    17640

cagttcgaca ctgtttacaa ggcgaagtcg gtgccgagga agatgccgga ctggcacttt    17700

atccagcaca agctgacaag ggaggacaga agcgacgcta agaaccagaa atggcacctc    17760

accgagcacg ccatcgccag tggctctgcg ctgcccgggt gaccctgcaa tgtgacccta    17820

gacttgtcca tcttctggat tggccaactt aattaatgta tgaaataaaa ggatgcacac    17880

atagtgacat gctaatcact ataatgtggg catcaaagtt gtgtgttatg tgtaattact    17940

aattatctga ataagagaaa gagatcatcc atatttctta tcctaaatga atgtcacgtg    18000

tctttataat tctttgatga accagatgca ttttattaac caattccata tacatataaa    18060

tattaatcat atataattaa tatcaattgg gttagcaaaa caaatctagt ctaggtgtgt    18120

tttgctaatt attgggggat agtgcaaaaa gaaatctacg ttctcaataa ttcagataga    18180

aaacttaata aagtgagata atttacatag attgctttta tcctttgata tatgtgaaac    18240

catgcatgat ataaggaaaa tagatagaga aataattttt tacatcgttg aatatgtaaa    18300

caatttaatt caagaagcta ggaatataaa tattgaggag tttatgatta ttattattat    18360

tttgatgttc aatgaagttt tttttaattt catatgaagt atacaaaaat tcttcataga    18420

tttttgtttc tatgccgtag ttatctttaa tatatttgtg gttgaagaaa tttattgcta    18480

gaaacgaatg gattgtcaat ttttttttaa agcaaatata tatgaaatta tactgtatat    18540

tattttagtc atgattaaaa tgtggcctta attgaatcat ctttctcatt cattttttca    18600

aaagcatatc aggatgattg atatttatct attttaaaaa ttaatttaag ggttcaaatt    18660

aaatttaact taaaagtgtc ctaaccgtag ttaaaggttt actttaaaaa aatactatga    18720

aaaatctaat cttctatgaa tcgagggccc ggccgtgacg gccacgagcg aactcctgca    18780

ggcgataaaa atgttttaaa cgatatatat tataaaaaaa aacgtttcaa aaataaatac    18840

aaaaatgttt ttaaatatat ataatttaac tcattaaaga aaataaaaat gcaagtgcgg    18900

tgacaagaca agctaaaagt tgcaaaagaa atggcagggc tataaggctc acctactcct    18960

ggatttacca aattttggtt cgtccctata ctcgaaaaat aaaacaaaat aaatttcagt    19020

atcttcgttt ttgtatgctt tgactgtgag gcgaggccaa ctttcttctt ctgtctgaga    19080

tgaattttgt ttgcctcctg tgaaggatgt atcattcaaa gtgaatgttt tgcaactgcc    19140

agtagtccca catcgaccaa atattcttat tacagtgtgt ttatatagca cctggagaag    19200

gaatgggttg tttcaaagat taaataattt ctactaagtg tagattgccg ttaatttgag    19260

agtccaagta atttctacta agtgtagatt tttttttgcg gccgcacaac aaacgcgccg    19320

gcga                                                                 19324


<210>  161
<211>  7858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3121 Full Plasmid Sequence

<400>  161
cggaaggagc tgactgggtt gaaggctctc aagggcatcg gtcgagatcc cggtgcctaa       60

tgagtgagct aacttacatt aattgcgttg cgccccggga tgagattatc aaaaaggatc      120

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgtg      180

taacattggt ctagtgattg gatccttgac agctagctca gtcctaggta ctgtgctagc      240

gctagcaaag aggagaaagg taccatgccc gatcgagctc aagttatcat tcgcattgtg      300

ccgggaggtg gcaccaagac ccttcaacaa attatcaatc agttggagta tctatcccgg      360

aagggcaggc tggagctgca gcgttcagcc cgacatctcg atattcccct gccaccggat      420

caaatccacg aacttgcccg aagctgggtt caagagactg gaacttatga cgaaagtcag      480

ccagacgagg aaaggcaaca ggagttgacc acccatatta ttgtaagctt ccccgccggt      540

acaagccagg tagcggctta tgcggcgagc cgggagtggg cagccgagat gtttgggtca      600

ggcgcagggg ggggccgata caactatctt acggccttcc acatcgatcg cgaccaccca      660

catctgcatg tcgtcgtcaa tcggcgcgaa cttttaggac acggctggct gaagatatct      720

cggcgccatc cccaactgaa ttacgacgcc ctgcgcataa agatggccga gatttcactt      780

cgtcatggca ttgccctcga tgcgagccga cgagcagaac gtggcatcac cgagcggccg      840

atcacttatg cccaatatcg gcgccttgag cgggagcagg ctcgccaaat ccgtttcgaa      900

gacgcggatt tggaacagtc gtcgccgcaa ggagatcatc cagaattcag ccaacctttc      960

gatacatccc catttgaagc atccgcgggc ggaccggagg acatgcctcg gcccaacaat     1020

cggcagaatg agtcgcaagt tcatctccag gagccagctg gtgtcagcaa cgaagccggt     1080

gtccttgtgc gggttgcatt ggaaacggag cgccttgctc aaccattcgt ttccgaaacc     1140

attctcgcgg acgacatagg gagcggctct tcgcgtgttg ccgagggccg tgtggagagc     1200

gcaaaccgca ctcccgatat tcctcgcgca gcaactgaag ctgccacgca cacgacacac     1260

gaccggcagc ggcgtgcaaa gcgtcctcat gatgacgacg gagggccgag tggagcaaaa     1320

cgtgtgacat tggaaggcat cgcggttggg ccccaggcga acgccggcga acaggatggc     1380

agtagtgggg gctcctcggg tggcagcatg agcggatcaa agaaacgtag gatcaagcaa     1440

gatggtccgg atattgttat gacccagagc ccgagcagcc tgagtgctag cgttggtgac     1500

cgtgttacca ttacgtgccg tagctcgacc ggtgcggtga ccacttctaa ctatgccagc     1560

tgggttcagg agaaaccggg taaacttttc aaaggtctta tcggcggtac gaacaaccgt     1620

gcgcctggtg tgccaagccg tttctccggt tctctgatcg gcgacaaagc tactctgacc     1680

atctcttccc tgcagccgga agattttgcg acctacttct gcgcgctgtg gtatagcaat     1740

cactgggtgt ttggccaagg tacgaaagtg gagctgaagc gcggtggtgg cggctccggc     1800

ggaggcggct ccggtggcgg cggaagctcc ggcggcggca gcgaagttaa actgctggag     1860

tcggggggcg gtctggttca accgggtggt tctctcaagt tgtcttgtgc tgtgagcggt     1920

tttagcttga ccgactacgg cgtgaattgg gtgcgtcagg caccgggccg tggtctggaa     1980

tggattggcg tcatctgggg cgatggtatt acggactaca acagcgcgct gaaggaccgc     2040

ttcatcatca gcaaggacaa tggtaagaac accgtctatc tgcaaatgag caaggtgaga     2100

tccgatgaca ccgcattgta ctactgcgtc accggtttgt ttgattactg gggtcagggc     2160

accttggtta ccgtgagctc ctatccgtat gacgttccgg attacgccgg tagcaagaaa     2220

cgccgtatta aacaagattc cggtagtggg gggtcctctg gtggaagtag tggcccctta     2280

gtacggcaag ctggaacgtc acggccatct ccaccgacgg ccacgacgcg ggccagcacc     2340

gcaaccgatt cattgtctgc tacagcccac ctccagcaac ggagaggtgt cctttcaaag     2400

cgtccgcgtg aagatgatga tggagaaccg agtgaacgca aacgcgagag agatgagcgc     2460

agcaaggacg ggcgtggggg aaataggaga tagtctagac caggcatcaa ataaaacgaa     2520

aggctcagtc gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg aacgctctct     2580

actagagtca cactggctca ccttcgggtg ggcctttctg cgtttatagt acgatatccc     2640

aatggcgcgc cgagcttggc tcgagcatgg tcatagctgt ttcctgtgtg aaattgttat     2700

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc     2760

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     2820

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     2880

attgggcgct gttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     2940

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     3000

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     3060

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     3120

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     3180

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     3240

ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag     3300

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     3360

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     3420

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg     3480

aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg     3540

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct     3600

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     3660

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     3720

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     3780

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttagaaaaac     3840

tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat accatatttt     3900

tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca taggatggca     3960

agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc tattaatttc     4020

ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac tgaatccggt     4080

gagaatggca aaagtttatg catttctttc cagacttgtt caacaggcca gccattacgc     4140

tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg     4200

aaacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga atgcaaccgg     4260

cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata ttcttctaat     4320

acctggaatg ctgttttccc agggatcgca gtggtgagta accatgcatc atcaggagta     4380

cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt tagtctgacc     4440

atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa caactctggc     4500

gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac attatcgcga     4560

gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg cctagagcaa     4620

gacgtttccc gttgaatatg gctcatactc ttcctttttc aatattattg aagcatttat     4680

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     4740

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc     4800

atgacattaa cctataaaaa taggcgtatc acgaggccct tttgtctcgc gcgtttcggt     4860

gatgacggtg aaaacctctg acacatgcag ctcccggaga ctgtcacagc ttgtctgtaa     4920

gcggatgccg ggagcagaca agcccgtcag ggcgcgtcag cgggtgttgg cgggtgtcgg     4980

ggctggctta actatgcggc atcagagcag attgtactga gagtgcacca tatgcggtgt     5040

gaaataccgc acagatgcgt aaggagaaaa taccgcatca ggcgccattc gccattcagg     5100

ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccagctggcg     5160

aaagggggat gtgctgcaag gcgattaagt tgggtaacgc cagggttttc ccagtcacga     5220

cgttgtaaaa cgacggccag tgaattgacg cgttgcggct gcatgaaatc ctggccggtt     5280

tgtctgatgc caagctggcg gcctggccgg ccagcttggc cgctgaagaa accgagcgcc     5340

gccgtctaaa aaggtgatgt gtatttgagt aaaacagctt gcgtcatgcg gtcgctgcgt     5400

atatgatgcg atgagtaaat aaacaaatac gcaaggggaa cgcatgaagg ttatcgctgt     5460

acttaaccag aaaggcgggt caggcaagac gaccatcgca acccatctag cccgcgccct     5520

gcaactcgcc ggggccgatg ttctgttagt cgattccgat ccccagggca gtgcccgcga     5580

ttgggcggcc gtgcgggaag atcaaccgct aaccgttgtc ggcatcgacc gcccgacgat     5640

tgaccgcgac gtgaaggcca tcggccggcg cgacttcgta gtgatcgacg gagcgcccca     5700

ggcggcggac ttggctgtgt ccgcgatcaa ggcagccgac ttcgtgctga ttccggtgca     5760

gccaagccct tacgacatat gggccaccgc cgacctggtg gagctggtta agcagcgcat     5820

tgaggtcacg gatggaaggc tacaagcggc ctttgtcgtg tcgcgggcga tcaaaggcac     5880

gcgcatcggc ggtgaggttg ccgaggcgct ggccgggtac gagctgccca ttcttgagtc     5940

ccgtatcacg cagcgcgtga gctacccagg cactgccgcc gccggcacaa ccgttcttga     6000

atcagaaccc gagggcgacg ctgcccgcga ggtccaggcg ctggccgctg aaattaaatc     6060

aaaactcatt tgagttaatg aggtaaagag aaaatgagca aaagcacaaa cacgctaagt     6120

gccggccgtc cgagcgcacg cagcagcaag gctgcaacgt tggccagcct ggcagacacg     6180

ccagccatga agcgggtcaa ctttcagttg ccggcggagg atcacaccaa gctgaagatg     6240

tacgcggtac gccaaggcaa gaccattacc gagctgctat ctgaatacat cgcgcagcta     6300

ccagagtaaa tgagcaaatg aataaatgag tagatgaatt ttagcggcta aaggaggcgg     6360

catggaaaat caagaacaac caggcaccga cgccgtggaa tgccccatgt gtggaggaac     6420

gggcggttgg ccaggcgtaa gcggctgggt tgtctgccgg ccctgcaatg gcactggaac     6480

ccccaagccc gaggaatcgg cgtgagcggt cgcaaaccat ccggcccggt acaaatcggc     6540

gcggcgctgg gtgatgacct ggtggagaag ttgaaggccg cgcaggccgc ccagcggcaa     6600

cgcatcgagg cagaagcacg ccccggtgaa tcgtggcaag cggccgctga tcgaatccgc     6660

aaagaatccc ggcaaccgcc ggcagccggt gcgccgtcga ttaggaagcc gcccaagggc     6720

gacgagcaac cagatttttt cgttccgatg ctctatgacg tgggcacccg cgatagtcgc     6780

agcatcatgg acgtggccgt tttccgtctg tcgaagcgtg accgacgagc tggcgaggtg     6840

atccgctacg agcttccaga cgggcacgta gaggtttccg cagggccggc cggcatggcc     6900

agtgtgtggg attacgacct ggtactgatg gcggtttccc atctaaccga atccatgaac     6960

cgataccggg aagggaaggg agacaagccc ggccgcgtgt tccgtccaca cgttgcggac     7020

gtactcaagt tctgccggcg agccgatggc ggaaagcaga aagacgacct ggtagaaacc     7080

tgcattcggt taaacaccac gcacgttgcc atgcagcgta cgaagaaggc caagaacggc     7140

cgcctggtga cggtatccga gggtgaagcc ttgattagcc gctacaagat cgtaaagagc     7200

gaaaccgggc ggccggagta catcgagatc gagctagctg attggatgta ccgcgagatc     7260

acagaaggca agaacccgga cgtgctgacg gttcaccccg attacttttt gatcgatccc     7320

ggcatcggcc gttttctcta ccgcctggca cgccgcgccg caggcaaggc agaagccaga     7380

tggttgttca agacgatcta cgaacgcagt ggcagcgccg gagagttcaa gaagttctgt     7440

ttcaccgtgc gcaagctgat cgggtcaaat gacctgccgg agtacgattt gaaggaggag     7500

gcggggcagg ctggcccgat cctagtcatg cgctaccgca acctgatcga gggcgaagca     7560

tccgccggtt cctaatgtac ggagcagatg ctagggcaaa ttgccctagc aggggaaaaa     7620

ggtcgaaaag gtctctttcc tgtggatagc acgtacattg ggaacccaaa gccgtacatt     7680

gggaaccgga acccgtacat tgggaaccca aagccgtaca ttgggaaccg gtcacacatg     7740

taagtgactg atataaaaga gaaaaaaggc gatttttccg cctaaaactc tttaaaactt     7800

attaaaactc ttaaaacccg cctggcctgt gcatatgcta gtcatgcccc gcgcccac       7858


<210>  162
<211>  8116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3117 Full Plasmid Sequence

<400>  162
caccggaagg agctgactgg gttgaaggct ctcaagggca tcggtcgaga tcccggtgcc       60

taatgagtga gctaacttac attaattgcg ttgcgccccg ggatgagatt atcaaaaagg      120

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat      180

gtgtaacatt ggtctagtga ttggatcctt gacagctagc tcagtcctag gtactgtgct      240

agcgctagca aagaggagaa aggtaccatg cccgatcgag ctcaagttat cattcgcatt      300

gtgccgggag gtggcaccaa gacccttcaa caaattatca atcagttgga gtatctatcc      360

cggaagggca ggctggagct gcagcgttca gcccgacatc tcgatattcc cctgccaccg      420

gatcaaatcc acgaacttgc ccgaagctgg gttcaagaga ctggaactta tgacgaaagt      480

cagccagacg aggaaaggca acaggagttg accacccata ttattgtaag cttccccgcc      540

ggtacaagcc aggtagcggc ttatgcggcg agccgggagt gggcagccga gatgtttggg      600

tcaggcgcag gggggggccg atacaactat cttacggcct tccacatcga tcgcgaccac      660

ccacatctgc atgtcgtcgt caatcggcgc gaacttttag gacacggctg gctgaagata      720

tctcggcgcc atccccaact gaattacgac gccctgcgca taaagatggc cgagatttca      780

cttcgtcatg gcattgccct cgatgcgagc cgacgagcag aacgtggcat caccgagcgg      840

ccgatcactt atgcccaata tcggcgcctt gagcgggagc aggctcgcca aatccgtttc      900

gaagacgcgg atttggaaca gtcgtcgccg caaggagatc atccagaatt cagccaacct      960

ttcgatacat ccccatttga agcatccgcg ggcggaccgg aggacatgcc tcggcccaac     1020

aatcggcaga atgagtcgca agttcatctc caggagccag ctggtgtcag caacgaagcc     1080

ggtgtccttg tgcgggttgc attggaaacg gagcgccttg ctcaaccatt cgtttccgaa     1140

accattctcg cggacgacat agggagcggc tcttcgcgtg ttgccgaggg ccgtgtggag     1200

agcgcaaacc gcactcccga tattcctcgc gcagcaactg aagctgccac gcacacgaca     1260

cacgaccggc agcggcgtgc aaagcgtcct catgatgacg acggagggcc gagtggagca     1320

aaacgtgtga cattggaagg catcgcggtt gggccccagg cgaacgccgg cgaacaggat     1380

ggcagtagtg ggggctcctc gggtggcagc atgagcggat caaagaaaag aaggatcaag     1440

caagatgagg aattgctgag taaaaactac catcttgaga acgaagttgc ccgtctgaag     1500

aagggtagcg gttcgggcgg tagcggttcc ggaggtagcg gcagcggctc gggtggtagc     1560

ggttcaggtg gctcaggcag tggtgaagaa ttgctgagca aaaattatca cctggagaat     1620

gaagttgcgc gtctgaagaa aggcagcggc tccggtggtt ctggctcggg cggttcaggt     1680

agtggttccg gtggctccgg cagcggtggt tctggctccg gtgaagagtt gttgtccaag     1740

aattatcatc tggaaaacga agtggcaaga ctcaagaagg gttcgggttc gggcggcagc     1800

ggaagtggtg gtagcggaag cggcagcggc ggctccggct ccggtggctc cggcagcggt     1860

gaggagctgc tgagcaagaa ctaccacttg gagaacgaag tggcacgcct gaagaaaggt     1920

agcggtagcg gcggttctgg gagcggtggc tccggaagcg gcagcggcgg ttcgggttct     1980

ggtggcagcg gtagcggcga agagctgctt agcaaaaatt atcaccttga gaacgaggtc     2040

gctcgcctga aaaaaggttc cggcagcggc ggtagcggta gcggtggcag cggtagcggc     2100

agcggtggct cggggtccgg tggtagcggc tccggtgaag aattgttgtc caaaaactac     2160

cacctggaga atgaagtggc gcgtctgaaa aagggtagcg gcagcggtgg tagcggctct     2220

ggaggtagcg gctccggtag tggcggtagc gggtctggcg gctctggttc aggcgaagaa     2280

ctgctcagca agaattacca tttggagaac gaggttgcgc gcctgaaaaa gggctctggt     2340

agcggcggtt ctggctctgg tggcagcggg agcggctccg gtggcagcgg ctctggaggt     2400

tccggttcgg gtgaggagct gctgagcaag aactaccacc tggaaaacga ggtggcgcgt     2460

ctgaaaaaag gcagcaagaa acgtcgtatc aaacaggact ccggtagtgg ggggtcctct     2520

ggtggaagta gtggcccctt agtacggcaa gctggaacgt cacggccatc tccaccgacg     2580

gccacgacgc gggccagcac cgcaaccgat tcattgtctg ctacagccca cctccagcaa     2640

cggagaggtg tcctttcaaa gcgtccgcgt gaagatgatg atggagaacc gagtgaacgc     2700

aaacgcgaga gagatgagcg cagcaaggac gggcgtgggg gaaataggag atagtctaga     2760

ccaggcatca aataaaacga aaggctcagt cgaaagactg ggcctttcgt tttatctgtt     2820

gtttgtcggt gaacgctctc tactagagtc acactggctc accttcgggt gggcctttct     2880

gcgtttatag tacgatatcc caatggcgcg ccgagcttgg ctcgagcatg gtcatagctg     2940

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata     3000

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca     3060

ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc     3120

gcggggagag gcggtttgcg tattgggcgc tgttccgctt cctcgctcac tgactcgctg     3180

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta     3240

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc     3300

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     3360

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     3420

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     3480

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     3540

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     3600

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     3660

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     3720

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     3780

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     3840

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     3900

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     3960

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     4020

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     4080

tggtctgaca gttagaaaaa ctcatcgagc atcaaatgaa actgcaattt attcatatca     4140

ggattatcaa taccatattt ttgaaaaagc cgtttctgta atgaaggaga aaactcaccg     4200

aggcagttcc ataggatggc aagatcctgg tatcggtctg cgattccgac tcgtccaaca     4260

tcaatacaac ctattaattt cccctcgtca aaaataaggt tatcaagtga gaaatcacca     4320

tgagtgacga ctgaatccgg tgagaatggc aaaagtttat gcatttcttt ccagacttgt     4380

tcaacaggcc agccattacg ctcgtcatca aaatcactcg catcaaccaa accgttattc     4440

attcgtgatt gcgcctgagc gaaacgaaat acgcgatcgc tgttaaaagg acaattacaa     4500

acaggaatcg aatgcaaccg gcgcaggaac actgccagcg catcaacaat attttcacct     4560

gaatcaggat attcttctaa tacctggaat gctgttttcc cagggatcgc agtggtgagt     4620

aaccatgcat catcaggagt acggataaaa tgcttgatgg tcggaagagg cataaattcc     4680

gtcagccagt ttagtctgac catctcatct gtaacatcat tggcaacgct acctttgcca     4740

tgtttcagaa acaactctgg cgcatcgggc ttcccataca atcgatagat tgtcgcacct     4800

gattgcccga cattatcgcg agcccattta tacccatata aatcagcatc catgttggaa     4860

tttaatcgcg gcctagagca agacgtttcc cgttgaatat ggctcatact cttccttttt     4920

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     4980

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac     5040

gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc     5100

ttttgtctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca gctcccggag     5160

actgtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca gggcgcgtca     5220

gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg catcagagca gattgtactg     5280

agagtgcacc atatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc     5340

aggcgccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct     5400

tcgctattac gccagctggc gaaaggggga tgtgctgcaa ggcgattaag ttgggtaacg     5460

ccagggtttt cccagtcacg acgttgtaaa acgacggcca gtgaattgac gcgttgcggc     5520

tgcatgaaat cctggccggt ttgtctgatg ccaagctggc ggcctggccg gccagcttgg     5580

ccgctgaaga aaccgagcgc cgccgtctaa aaaggtgatg tgtatttgag taaaacagct     5640

tgcgtcatgc ggtcgctgcg tatatgatgc gatgagtaaa taaacaaata cgcaagggga     5700

acgcatgaag gttatcgctg tacttaacca gaaaggcggg tcaggcaaga cgaccatcgc     5760

aacccatcta gcccgcgccc tgcaactcgc cggggccgat gttctgttag tcgattccga     5820

tccccagggc agtgcccgcg attgggcggc cgtgcgggaa gatcaaccgc taaccgttgt     5880

cggcatcgac cgcccgacga ttgaccgcga cgtgaaggcc atcggccggc gcgacttcgt     5940

agtgatcgac ggagcgcccc aggcggcgga cttggctgtg tccgcgatca aggcagccga     6000

cttcgtgctg attccggtgc agccaagccc ttacgacata tgggccaccg ccgacctggt     6060

ggagctggtt aagcagcgca ttgaggtcac ggatggaagg ctacaagcgg cctttgtcgt     6120

gtcgcgggcg atcaaaggca cgcgcatcgg cggtgaggtt gccgaggcgc tggccgggta     6180

cgagctgccc attcttgagt cccgtatcac gcagcgcgtg agctacccag gcactgccgc     6240

cgccggcaca accgttcttg aatcagaacc cgagggcgac gctgcccgcg aggtccaggc     6300

gctggccgct gaaattaaat caaaactcat ttgagttaat gaggtaaaga gaaaatgagc     6360

aaaagcacaa acacgctaag tgccggccgt ccgagcgcac gcagcagcaa ggctgcaacg     6420

ttggccagcc tggcagacac gccagccatg aagcgggtca actttcagtt gccggcggag     6480

gatcacacca agctgaagat gtacgcggta cgccaaggca agaccattac cgagctgcta     6540

tctgaataca tcgcgcagct accagagtaa atgagcaaat gaataaatga gtagatgaat     6600

tttagcggct aaaggaggcg gcatggaaaa tcaagaacaa ccaggcaccg acgccgtgga     6660

atgccccatg tgtggaggaa cgggcggttg gccaggcgta agcggctggg ttgtctgccg     6720

gccctgcaat ggcactggaa cccccaagcc cgaggaatcg gcgtgagcgg tcgcaaacca     6780

tccggcccgg tacaaatcgg cgcggcgctg ggtgatgacc tggtggagaa gttgaaggcc     6840

gcgcaggccg cccagcggca acgcatcgag gcagaagcac gccccggtga atcgtggcaa     6900

gcggccgctg atcgaatccg caaagaatcc cggcaaccgc cggcagccgg tgcgccgtcg     6960

attaggaagc cgcccaaggg cgacgagcaa ccagattttt tcgttccgat gctctatgac     7020

gtgggcaccc gcgatagtcg cagcatcatg gacgtggccg ttttccgtct gtcgaagcgt     7080

gaccgacgag ctggcgaggt gatccgctac gagcttccag acgggcacgt agaggtttcc     7140

gcagggccgg ccggcatggc cagtgtgtgg gattacgacc tggtactgat ggcggtttcc     7200

catctaaccg aatccatgaa ccgataccgg gaagggaagg gagacaagcc cggccgcgtg     7260

ttccgtccac acgttgcgga cgtactcaag ttctgccggc gagccgatgg cggaaagcag     7320

aaagacgacc tggtagaaac ctgcattcgg ttaaacacca cgcacgttgc catgcagcgt     7380

acgaagaagg ccaagaacgg ccgcctggtg acggtatccg agggtgaagc cttgattagc     7440

cgctacaaga tcgtaaagag cgaaaccggg cggccggagt acatcgagat cgagctagct     7500

gattggatgt accgcgagat cacagaaggc aagaacccgg acgtgctgac ggttcacccc     7560

gattactttt tgatcgatcc cggcatcggc cgttttctct accgcctggc acgccgcgcc     7620

gcaggcaagg cagaagccag atggttgttc aagacgatct acgaacgcag tggcagcgcc     7680

ggagagttca agaagttctg tttcaccgtg cgcaagctga tcgggtcaaa tgacctgccg     7740

gagtacgatt tgaaggagga ggcggggcag gctggcccga tcctagtcat gcgctaccgc     7800

aacctgatcg agggcgaagc atccgccggt tcctaatgta cggagcagat gctagggcaa     7860

attgccctag caggggaaaa aggtcgaaaa ggtctctttc ctgtggatag cacgtacatt     7920

gggaacccaa agccgtacat tgggaaccgg aacccgtaca ttgggaaccc aaagccgtac     7980

attgggaacc ggtcacacat gtaagtgact gatataaaag agaaaaaagg cgatttttcc     8040

gcctaaaact ctttaaaact tattaaaact cttaaaaccc gcctggcctg tgcatatgct     8100

agtcatgccc cgcgcc                                                     8116


<210>  163
<211>  7900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3107 Full Plasmid Sequence

<400>  163
gtcatgcccc gcgcccaccg gaaggagctg actgggttga aggctctcaa gggcatcggt       60

cgagatcccg gtgcctaatg agtgagctaa cttacattaa ttgcgttgcg ccccgggatg      120

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca      180

atctaaagta tatatgtgta acattggtct agtgattgga tccttgacag ctagctcagt      240

cctaggtact gtgctagcgc tagcaaagag gagaaaggta ccatgagcgg atcaaagaaa      300

cgtaggatca agcaagatgg tccggatatt gttatgaccc agagcccgag cagcctgagt      360

gctagcgttg gtgaccgtgt taccattacg tgccgtagct cgaccggtgc ggtgaccact      420

tctaactatg ccagctgggt tcaggagaaa ccgggtaaac ttttcaaagg tcttatcggc      480

ggtacgaaca accgtgcgcc tggtgtgcca agccgtttct ccggttctct gatcggcgac      540

aaagctactc tgaccatctc ttccctgcag ccggaagatt ttgcgaccta cttctgcgcg      600

ctgtggtata gcaatcactg ggtgtttggc caaggtacga aagtggagct gaagcgcggt      660

ggtggcggct ccggcggagg cggctccggt ggcggcggaa gctccggcgg cggcagcgaa      720

gttaaactgc tggagtcggg gggcggtctg gttcaaccgg gtggttctct caagttgtct      780

tgtgctgtga gcggttttag cttgaccgac tacggcgtga attgggtgcg tcaggcaccg      840

ggccgtggtc tggaatggat tggcgtcatc tggggcgatg gtattacgga ctacaacagc      900

gcgctgaagg accgcttcat catcagcaag gacaatggta agaacaccgt ctatctgcaa      960

atgagcaagg tgagatccga tgacaccgca ttgtactact gcgtcaccgg tttgtttgat     1020

tactggggtc agggcacctt ggttaccgtg agctcctatc cgtatgacgt tccggattac     1080

gccggtagca agaaacgccg tattaaacaa gattccggtg gaagttccgg aggttcaagc     1140

gggtctgaaa cgccgggcac cagcgagtcg gcgaccccgg aaagcagcgg tggttcttcc     1200

ggcggtagca tgcccgatcg agctcaagtt atcattcgca ttgtgccggg aggtggcacc     1260

aagacccttc aacaaattat caatcagttg gagtatctat cccggaaggg caggctggag     1320

ctgcagcgtt cagcccgaca tctcgatatt cccctgccac cggatcaaat ccacgaactt     1380

gcccgaagct gggttcaaga gactggaact tatgacgaaa gtcagccaga cgaggaaagg     1440

caacaggagt tgaccaccca tattattgta agcttccccg ccggtacaag ccaggtagcg     1500

gcttatgcgg cgagccggga gtgggcagcc gagatgtttg ggtcaggcgc aggggggggc     1560

cgatacaact atcttacggc cttccacatc gatcgcgacc acccacatct gcatgtcgtc     1620

gtcaatcggc gcgaactttt aggacacggc tggctgaaga tatctcggcg ccatccccaa     1680

ctgaattacg acgccctgcg cataaagatg gccgagattt cacttcgtca tggcattgcc     1740

ctcgatgcga gccgacgagc agaacgtggc atcaccgagc ggccgatcac ttatgcccaa     1800

tatcggcgcc ttgagcggga gcaggctcgc caaatccgtt tcgaagacgc ggatttggaa     1860

cagtcgtcgc cgcaaggaga tcatccagaa ttcagccaac ctttcgatac atccccattt     1920

gaagcatccg cgggcggacc ggaggacatg cctcggccca acaatcggca gaatgagtcg     1980

caagttcatc tccaggagcc agctggtgtc agcaacgaag ccggtgtcct tgtgcgggtt     2040

gcattggaaa cggagcgcct tgctcaacca ttcgtttccg aaaccattct cgcggacgac     2100

atagggagcg gctcttcgcg tgttgccgag ggccgtgtgg agagcgcaaa ccgcactccc     2160

gatattcctc gcgcagcaac tgaagctgcc acgcacacga cacacgaccg gcagcggcgt     2220

gcaaagcgtc ctcatgatga cgacggaggg ccgagtggag caaaacgtgt gacattggaa     2280

ggcatcgcgg ttgggcccca ggcgaacgcc ggcgaacagg atggcagtag tggcccctta     2340

gtacggcaag ctggaacgtc acggccatct ccaccgacgg ccacgacgcg ggccagcacc     2400

gcaaccgatt cattgtctgc tacagcccac ctccagcaac ggagaggtgt cctttcaaag     2460

cgtccgcgtg aagatgatga tggagaaccg agtgaacgca aacgcgagag agatgagcgc     2520

agcaaggacg ggcgtggggg aaataggaga tagtctagac caggcatcaa ataaaacgaa     2580

aggctcagtc gaaagactgg gcctttcgtt ttatctgttg tttgtcggtg aacgctctct     2640

actagagtca cactggctca ccttcgggtg ggcctttctg cgtttatagt acgatatccc     2700

aatggcgcgc cgagcttggc tcgagcatgg tcatagctgt ttcctgtgtg aaattgttat     2760

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc     2820

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     2880

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     2940

attgggcgct gttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     3000

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     3060

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     3120

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     3180

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     3240

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     3300

ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag     3360

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     3420

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     3480

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg     3540

aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg     3600

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct     3660

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     3720

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     3780

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     3840

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttagaaaaac     3900

tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat accatatttt     3960

tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca taggatggca     4020

agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc tattaatttc     4080

ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac tgaatccggt     4140

gagaatggca aaagtttatg catttctttc cagacttgtt caacaggcca gccattacgc     4200

tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg     4260

aaacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga atgcaaccgg     4320

cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata ttcttctaat     4380

acctggaatg ctgttttccc agggatcgca gtggtgagta accatgcatc atcaggagta     4440

cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt tagtctgacc     4500

atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa caactctggc     4560

gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac attatcgcga     4620

gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg cctagagcaa     4680

gacgtttccc gttgaatatg gctcatactc ttcctttttc aatattattg aagcatttat     4740

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     4800

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc     4860

atgacattaa cctataaaaa taggcgtatc acgaggccct tttgtctcgc gcgtttcggt     4920

gatgacggtg aaaacctctg acacatgcag ctcccggaga ctgtcacagc ttgtctgtaa     4980

gcggatgccg ggagcagaca agcccgtcag ggcgcgtcag cgggtgttgg cgggtgtcgg     5040

ggctggctta actatgcggc atcagagcag attgtactga gagtgcacca tatgcggtgt     5100

gaaataccgc acagatgcgt aaggagaaaa taccgcatca ggcgccattc gccattcagg     5160

ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccagctggcg     5220

aaagggggat gtgctgcaag gcgattaagt tgggtaacgc cagggttttc ccagtcacga     5280

cgttgtaaaa cgacggccag tgaattgacg cgttgcggct gcatgaaatc ctggccggtt     5340

tgtctgatgc caagctggcg gcctggccgg ccagcttggc cgctgaagaa accgagcgcc     5400

gccgtctaaa aaggtgatgt gtatttgagt aaaacagctt gcgtcatgcg gtcgctgcgt     5460

atatgatgcg atgagtaaat aaacaaatac gcaaggggaa cgcatgaagg ttatcgctgt     5520

acttaaccag aaaggcgggt caggcaagac gaccatcgca acccatctag cccgcgccct     5580

gcaactcgcc ggggccgatg ttctgttagt cgattccgat ccccagggca gtgcccgcga     5640

ttgggcggcc gtgcgggaag atcaaccgct aaccgttgtc ggcatcgacc gcccgacgat     5700

tgaccgcgac gtgaaggcca tcggccggcg cgacttcgta gtgatcgacg gagcgcccca     5760

ggcggcggac ttggctgtgt ccgcgatcaa ggcagccgac ttcgtgctga ttccggtgca     5820

gccaagccct tacgacatat gggccaccgc cgacctggtg gagctggtta agcagcgcat     5880

tgaggtcacg gatggaaggc tacaagcggc ctttgtcgtg tcgcgggcga tcaaaggcac     5940

gcgcatcggc ggtgaggttg ccgaggcgct ggccgggtac gagctgccca ttcttgagtc     6000

ccgtatcacg cagcgcgtga gctacccagg cactgccgcc gccggcacaa ccgttcttga     6060

atcagaaccc gagggcgacg ctgcccgcga ggtccaggcg ctggccgctg aaattaaatc     6120

aaaactcatt tgagttaatg aggtaaagag aaaatgagca aaagcacaaa cacgctaagt     6180

gccggccgtc cgagcgcacg cagcagcaag gctgcaacgt tggccagcct ggcagacacg     6240

ccagccatga agcgggtcaa ctttcagttg ccggcggagg atcacaccaa gctgaagatg     6300

tacgcggtac gccaaggcaa gaccattacc gagctgctat ctgaatacat cgcgcagcta     6360

ccagagtaaa tgagcaaatg aataaatgag tagatgaatt ttagcggcta aaggaggcgg     6420

catggaaaat caagaacaac caggcaccga cgccgtggaa tgccccatgt gtggaggaac     6480

gggcggttgg ccaggcgtaa gcggctgggt tgtctgccgg ccctgcaatg gcactggaac     6540

ccccaagccc gaggaatcgg cgtgagcggt cgcaaaccat ccggcccggt acaaatcggc     6600

gcggcgctgg gtgatgacct ggtggagaag ttgaaggccg cgcaggccgc ccagcggcaa     6660

cgcatcgagg cagaagcacg ccccggtgaa tcgtggcaag cggccgctga tcgaatccgc     6720

aaagaatccc ggcaaccgcc ggcagccggt gcgccgtcga ttaggaagcc gcccaagggc     6780

gacgagcaac cagatttttt cgttccgatg ctctatgacg tgggcacccg cgatagtcgc     6840

agcatcatgg acgtggccgt tttccgtctg tcgaagcgtg accgacgagc tggcgaggtg     6900

atccgctacg agcttccaga cgggcacgta gaggtttccg cagggccggc cggcatggcc     6960

agtgtgtggg attacgacct ggtactgatg gcggtttccc atctaaccga atccatgaac     7020

cgataccggg aagggaaggg agacaagccc ggccgcgtgt tccgtccaca cgttgcggac     7080

gtactcaagt tctgccggcg agccgatggc ggaaagcaga aagacgacct ggtagaaacc     7140

tgcattcggt taaacaccac gcacgttgcc atgcagcgta cgaagaaggc caagaacggc     7200

cgcctggtga cggtatccga gggtgaagcc ttgattagcc gctacaagat cgtaaagagc     7260

gaaaccgggc ggccggagta catcgagatc gagctagctg attggatgta ccgcgagatc     7320

acagaaggca agaacccgga cgtgctgacg gttcaccccg attacttttt gatcgatccc     7380

ggcatcggcc gttttctcta ccgcctggca cgccgcgccg caggcaaggc agaagccaga     7440

tggttgttca agacgatcta cgaacgcagt ggcagcgccg gagagttcaa gaagttctgt     7500

ttcaccgtgc gcaagctgat cgggtcaaat gacctgccgg agtacgattt gaaggaggag     7560

gcggggcagg ctggcccgat cctagtcatg cgctaccgca acctgatcga gggcgaagca     7620

tccgccggtt cctaatgtac ggagcagatg ctagggcaaa ttgccctagc aggggaaaaa     7680

ggtcgaaaag gtctctttcc tgtggatagc acgtacattg ggaacccaaa gccgtacatt     7740

gggaaccgga acccgtacat tgggaaccca aagccgtaca ttgggaaccg gtcacacatg     7800

taagtgactg atataaaaga gaaaaaaggc gatttttccg cctaaaactc tttaaaactt     7860

attaaaactc ttaaaacccg cctggcctgt gcatatgcta                           7900


<210>  164
<211>  8002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pWISE3114 Full Plasmid Sequence

<400>  164
ccgcgcccac cggaaggagc tgactgggtt gaaggctctc aagggcatcg gtcgagatcc       60

cggtgcctaa tgagtgagct aacttacatt aattgcgttg cgccccggga tgagattatc      120

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag      180

tatatatgtg taacattggt ctagtgattg gatccttgac agctagctca gtcctaggta      240

ctgtgctagc gctagcaaag aggagaaagg taccatgccc gatcgagctc aagttatcat      300

tcgcattgtg ccgggaggtg gcaccaagac ccttcaacaa attatcaatc agttggagta      360

tctatcccgg aagggcaggc tggagctgca gcgttcagcc cgacatctcg atattcccct      420

gccaccggat caaatccacg aacttgcccg aagctgggtt caagagactg gaacttatga      480

cgaaagtcag ccagacgagg aaaggcaaca ggagttgacc acccatatta ttgtaagctt      540

ccccgccggt acaagccagg tagcggctta tgcggcgagc cgggagtggg cagccgagat      600

gtttgggtca ggcgcagggg ggggccgata caactatctt acggccttcc acatcgatcg      660

cgaccaccca catctgcatg tcgtcgtcaa tcggcgcgaa cttttaggac acggctggct      720

gaagatatct cggcgccatc cccaactgaa ttacgacgcc ctgcgcataa agatggccga      780

gatttcactt cgtcatggca ttgccctcga tgcgagccga cgagcagaac gtggcatcac      840

cgagcggccg atcacttatg cccaatatcg gcgccttgag cgggagcagg ctcgccaaat      900

ccgtttcgaa gacgcggatt tggaacagtc gtcgccgcaa ggagatcatc cagaattcag      960

ccaacctttc gatacatccc catttgaagc atccgcgggc ggaccggagg acatgcctcg     1020

gcccaacaat cggcagaatg agtcgcaagt tcatctccag gagccagctg gtgtcagcaa     1080

cgaagccggt gtccttgtgc gggttgcatt ggaaacggag cgccttgctc aaccattcgt     1140

ttccgaaacc attctcgcgg acgacatagg gagcggctct tcgcgtgttg ccgagggccg     1200

tgtggagagc gcaaaccgca ctcccgatat tcctcgcgca gcaactgaag ctgccacgca     1260

cacgacacac gaccggcagc ggcgtgcaaa gcgtcctcat gatgacgacg gagggccgag     1320

tggagcaaaa cgtgtgacat tggaaggcat cgcggttggg ccccaggcga acgccggcga     1380

acaggatggc agtagtggcc ccttagtacg gcaagctgga acgtcacggc catctccacc     1440

gacggccacg acgcgggcca gcaccgcaac cgattcattg tctgctacag cccacctcca     1500

gcaacggaga ggtgtccttt caaagcgtcc gcgtgaagat gatgatggag aaccgagtga     1560

acgcaaacgc gagagagatg agcgcagcaa ggacgggcgt gggggaaata ggagaagcgg     1620

tggctcctcg ggtggcagca tgagcggatc aaagaaacgt aggatcaagc aagatggtcc     1680

ggatattgtt atgacccaga gcccgagcag cctgagtgct agcgttggtg accgtgttac     1740

cattacgtgc cgtagctcga ccggtgcggt gaccacttct aactatgcca gctgggttca     1800

ggagaaaccg ggtaaacttt tcaaaggtct tatcggcggt acgaacaacc gtgcgcctgg     1860

tgtgccaagc cgtttctccg gttctctgat cggcgacaaa gctactctga ccatctcttc     1920

cctgcagccg gaagattttg cgacctactt ctgcgcgctg tggtatagca atcactgggt     1980

gtttggccaa ggtacgaaag tggagctgaa gcgcggtggt ggcggctccg gcggaggcgg     2040

ctccggtggc ggcggaagct ccggcggcgg cagcgaagtt aaactgctgg agtcgggggg     2100

cggtctggtt caaccgggtg gttctctcaa gttgtcttgt gctgtgagcg gttttagctt     2160

gaccgactac ggcgtgaatt gggtgcgtca ggcaccgggc cgtggtctgg aatggattgg     2220

cgtcatctgg ggcgatggta ttacggacta caacagcgcg ctgaaggacc gcttcatcat     2280

cagcaaggac aatggtaaga acaccgtcta tctgcaaatg agcaaggtga gatccgatga     2340

caccgcattg tactactgcg tcaccggttt gtttgattac tggggtcagg gcaccttggt     2400

taccgtgagc tcctatccgt atgacgttcc ggattacgcc ggtagcaaga aacgccgtat     2460

taaacaagat tccggtggca gttccggtgg cagcagtgcg tcgttagcaa gaggcggtcc     2520

aaatgcagtg ggactcctaa cgacgaacga aagctttgag aaaaatatca atgaggtcta     2580

caaccgtacg cgagccgagc tagacgcttc ttcacgtgac agaagtcgct ctggactatc     2640

gcgataatct agaccaggca tcaaataaaa cgaaaggctc agtcgaaaga ctgggccttt     2700

cgttttatct gttgtttgtc ggtgaacgct ctctactaga gtcacactgg ctcaccttcg     2760

ggtgggcctt tctgcgttta tagtacgata tcccaatggc gcgccgagct tggctcgagc     2820

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     2880

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     2940

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     3000

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctgttccg cttcctcgct     3060

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     3120

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     3180

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     3240

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     3300

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     3360

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     3420

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     3480

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     3540

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     3600

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     3660

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     3720

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     3780

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     3840

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     3900

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     3960

atatgagtaa acttggtctg acagttagaa aaactcatcg agcatcaaat gaaactgcaa     4020

tttattcata tcaggattat caataccata tttttgaaaa agccgtttct gtaatgaagg     4080

agaaaactca ccgaggcagt tccataggat ggcaagatcc tggtatcggt ctgcgattcc     4140

gactcgtcca acatcaatac aacctattaa tttcccctcg tcaaaaataa ggttatcaag     4200

tgagaaatca ccatgagtga cgactgaatc cggtgagaat ggcaaaagtt tatgcatttc     4260

tttccagact tgttcaacag gccagccatt acgctcgtca tcaaaatcac tcgcatcaac     4320

caaaccgtta ttcattcgtg attgcgcctg agcgaaacga aatacgcgat cgctgttaaa     4380

aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg aacactgcca gcgcatcaac     4440

aatattttca cctgaatcag gatattcttc taatacctgg aatgctgttt tcccagggat     4500

cgcagtggtg agtaaccatg catcatcagg agtacggata aaatgcttga tggtcggaag     4560

aggcataaat tccgtcagcc agtttagtct gaccatctca tctgtaacat cattggcaac     4620

gctacctttg ccatgtttca gaaacaactc tggcgcatcg ggcttcccat acaatcgata     4680

gattgtcgca cctgattgcc cgacattatc gcgagcccat ttatacccat ataaatcagc     4740

atccatgttg gaatttaatc gcggcctaga gcaagacgtt tcccgttgaa tatggctcat     4800

actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata     4860

catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa     4920

agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata aaaataggcg     4980

tatcacgagg cccttttgtc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat     5040

gcagctcccg gagactgtca cagcttgtct gtaagcggat gccgggagca gacaagcccg     5100

tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg cggcatcaga     5160

gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat gcgtaaggag     5220

aaaataccgc atcaggcgcc attcgccatt caggctgcgc aactgttggg aagggcgatc     5280

ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt     5340

aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt     5400

gacgcgttgc ggctgcatga aatcctggcc ggtttgtctg atgccaagct ggcggcctgg     5460

ccggccagct tggccgctga agaaaccgag cgccgccgtc taaaaaggtg atgtgtattt     5520

gagtaaaaca gcttgcgtca tgcggtcgct gcgtatatga tgcgatgagt aaataaacaa     5580

atacgcaagg ggaacgcatg aaggttatcg ctgtacttaa ccagaaaggc gggtcaggca     5640

agacgaccat cgcaacccat ctagcccgcg ccctgcaact cgccggggcc gatgttctgt     5700

tagtcgattc cgatccccag ggcagtgccc gcgattgggc ggccgtgcgg gaagatcaac     5760

cgctaaccgt tgtcggcatc gaccgcccga cgattgaccg cgacgtgaag gccatcggcc     5820

ggcgcgactt cgtagtgatc gacggagcgc cccaggcggc ggacttggct gtgtccgcga     5880

tcaaggcagc cgacttcgtg ctgattccgg tgcagccaag cccttacgac atatgggcca     5940

ccgccgacct ggtggagctg gttaagcagc gcattgaggt cacggatgga aggctacaag     6000

cggcctttgt cgtgtcgcgg gcgatcaaag gcacgcgcat cggcggtgag gttgccgagg     6060

cgctggccgg gtacgagctg cccattcttg agtcccgtat cacgcagcgc gtgagctacc     6120

caggcactgc cgccgccggc acaaccgttc ttgaatcaga acccgagggc gacgctgccc     6180

gcgaggtcca ggcgctggcc gctgaaatta aatcaaaact catttgagtt aatgaggtaa     6240

agagaaaatg agcaaaagca caaacacgct aagtgccggc cgtccgagcg cacgcagcag     6300

caaggctgca acgttggcca gcctggcaga cacgccagcc atgaagcggg tcaactttca     6360

gttgccggcg gaggatcaca ccaagctgaa gatgtacgcg gtacgccaag gcaagaccat     6420

taccgagctg ctatctgaat acatcgcgca gctaccagag taaatgagca aatgaataaa     6480

tgagtagatg aattttagcg gctaaaggag gcggcatgga aaatcaagaa caaccaggca     6540

ccgacgccgt ggaatgcccc atgtgtggag gaacgggcgg ttggccaggc gtaagcggct     6600

gggttgtctg ccggccctgc aatggcactg gaacccccaa gcccgaggaa tcggcgtgag     6660

cggtcgcaaa ccatccggcc cggtacaaat cggcgcggcg ctgggtgatg acctggtgga     6720

gaagttgaag gccgcgcagg ccgcccagcg gcaacgcatc gaggcagaag cacgccccgg     6780

tgaatcgtgg caagcggccg ctgatcgaat ccgcaaagaa tcccggcaac cgccggcagc     6840

cggtgcgccg tcgattagga agccgcccaa gggcgacgag caaccagatt ttttcgttcc     6900

gatgctctat gacgtgggca cccgcgatag tcgcagcatc atggacgtgg ccgttttccg     6960

tctgtcgaag cgtgaccgac gagctggcga ggtgatccgc tacgagcttc cagacgggca     7020

cgtagaggtt tccgcagggc cggccggcat ggccagtgtg tgggattacg acctggtact     7080

gatggcggtt tcccatctaa ccgaatccat gaaccgatac cgggaaggga agggagacaa     7140

gcccggccgc gtgttccgtc cacacgttgc ggacgtactc aagttctgcc ggcgagccga     7200

tggcggaaag cagaaagacg acctggtaga aacctgcatt cggttaaaca ccacgcacgt     7260

tgccatgcag cgtacgaaga aggccaagaa cggccgcctg gtgacggtat ccgagggtga     7320

agccttgatt agccgctaca agatcgtaaa gagcgaaacc gggcggccgg agtacatcga     7380

gatcgagcta gctgattgga tgtaccgcga gatcacagaa ggcaagaacc cggacgtgct     7440

gacggttcac cccgattact ttttgatcga tcccggcatc ggccgttttc tctaccgcct     7500

ggcacgccgc gccgcaggca aggcagaagc cagatggttg ttcaagacga tctacgaacg     7560

cagtggcagc gccggagagt tcaagaagtt ctgtttcacc gtgcgcaagc tgatcgggtc     7620

aaatgacctg ccggagtacg atttgaagga ggaggcgggg caggctggcc cgatcctagt     7680

catgcgctac cgcaacctga tcgagggcga agcatccgcc ggttcctaat gtacggagca     7740

gatgctaggg caaattgccc tagcagggga aaaaggtcga aaaggtctct ttcctgtgga     7800

tagcacgtac attgggaacc caaagccgta cattgggaac cggaacccgt acattgggaa     7860

cccaaagccg tacattggga accggtcaca catgtaagtg actgatataa aagagaaaaa     7920

aggcgatttt tccgcctaaa actctttaaa acttattaaa actcttaaaa cccgcctggc     7980

ctgtgcatat gctagtcatg cc                                              8002


<210>  165
<211>  171
<212>  DNA
<213>  Agrobacterium tumefaciens strain C58

<400>  165
ggcagttccg gtggcagcag tgcgtcgtta gcaagaggcg gtccaaatgc agtgggactc       60

ctaacgacga acgaaagctt tgagaaaaat atcaatgagg tctacaaccg tacgcgagcc      120

gagctagacg cttcttcacg tgacagaagt cgctctggac tatcgcgata a               171


<210>  166
<211>  74
<212>  PRT
<213>  Agrobacterium tumefaciens

<400>  166

Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser Arg Pro Ser Pro Pro 
1               5                   10                  15      


Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp Ser Leu Ser Ala Thr 
            20                  25                  30          


Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser Lys Arg Pro Arg Glu 
        35                  40                  45              


Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg Glu Arg Asp Glu Arg 
    50                  55                  60                  


Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg 
65                  70                  


<210>  167
<211>  50
<212>  PRT
<213>  Agrobacterium tumefaciens strain C58

<400>  167

Ser Ala Ser Leu Ala Arg Gly Gly Pro Asn Ala Val Gly Leu Leu Thr 
1               5                   10                  15      


Thr Asn Glu Ser Phe Glu Lys Asn Ile Asn Glu Val Tyr Asn Arg Thr 
            20                  25                  30          


Arg Ala Glu Leu Asp Ala Ser Ser Arg Asp Arg Ser Arg Ser Gly Leu 
        35                  40                  45              


Ser Arg 
    50  


<210>  168
<211>  373
<212>  PRT
<213>  Agrobacterium tumefaciens

<400>  168

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser 
    370             


<210>  169
<211>  275
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  169

Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Gly Pro Asp Ile Val Met 
1               5                   10                  15      


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
            20                  25                  30          


Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
        35                  40                  45              


Ser Trp Val Gln Glu Lys Pro Gly Lys Leu Phe Lys Gly Leu Ile Gly 
    50                  55                  60                  


Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg Phe Ser Gly Ser 
65                  70                  75                  80  


Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
                85                  90                  95      


Asp Phe Ala Thr Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His Trp Val 
            100                 105                 110         


Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly 
                165                 170                 175     


Val Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys Asp 
        195                 200                 205             


Arg Phe Ile Ile Ser Lys Asp Asn Gly Lys Asn Thr Val Tyr Leu Gln 
    210                 215                 220                 


Met Ser Lys Val Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys Val Thr 
225                 230                 235                 240 


Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Lys Lys Arg Arg Ile 
            260                 265                 270         


Lys Gln Asp 
        275 


<210>  170
<211>  742
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::scFV fusion

<400>  170

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ser Gly 
    370                 375                 380                 


Ser Lys Lys Arg Arg Ile Lys Gln Asp Gly Pro Asp Ile Val Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Ser 
            420                 425                 430         


Trp Val Gln Glu Lys Pro Gly Lys Leu Phe Lys Gly Leu Ile Gly Gly 
        435                 440                 445             


Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
465                 470                 475                 480 


Phe Ala Thr Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe 
                485                 490                 495     


Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val 
        515                 520                 525             


Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    530                 535                 540                 


Lys Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val 
545                 550                 555                 560 


Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Ile Gly Val 
                565                 570                 575     


Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys Asp Arg 
            580                 585                 590         


Phe Ile Ile Ser Lys Asp Asn Gly Lys Asn Thr Val Tyr Leu Gln Met 
        595                 600                 605             


Ser Lys Val Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys Val Thr Gly 
    610                 615                 620                 


Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Tyr 
625                 630                 635                 640 


Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Lys Lys Arg Arg Ile Lys 
                645                 650                 655     


Gln Asp Ser Gly Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Pro Leu 
            660                 665                 670         


Val Arg Gln Ala Gly Thr Ser Arg Pro Ser Pro Pro Thr Ala Thr Thr 
        675                 680                 685             


Arg Ala Ser Thr Ala Thr Asp Ser Leu Ser Ala Thr Ala His Leu Gln 
    690                 695                 700                 


Gln Arg Arg Gly Val Leu Ser Lys Arg Pro Arg Glu Asp Asp Asp Gly 
705                 710                 715                 720 


Glu Pro Ser Glu Arg Lys Arg Glu Arg Asp Glu Arg Ser Lys Asp Gly 
                725                 730                 735     


Arg Gly Gly Asn Arg Arg 
            740         


<210>  171
<211>  1228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Lachnospiraceae bacterium ND2006

<400>  171

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  172
<211>  19
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  172

Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
1               5                   10                  15      


Leu Lys Lys 
            


<210>  173
<211>  1593
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic 8xGCN4::Cas12a fusion

<400>  173

Met Ala Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val 
1               5                   10                  15      


Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
        35                  40                  45              


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
    50                  55                  60                  


Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu 
                85                  90                  95      


Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
            100                 105                 110         


Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu 
    130                 135                 140                 


Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly 
145                 150                 155                 160 


Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly 
                165                 170                 175     


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys 
            180                 185                 190         


Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly 
        195                 200                 205             


Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser 
    210                 215                 220                 


Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
225                 230                 235                 240 


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
                245                 250                 255     


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser 
            260                 265                 270         


Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu 
        275                 280                 285             


Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser 
    290                 295                 300                 


Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn 
                325                 330                 335     


Glu Val Ala Arg Leu Lys Lys Gly Ser Ser Glu Thr Pro Gly Thr Ser 
            340                 345                 350         


Glu Ser Ala Thr Pro Glu Gly Gly Ser Gly Gly Ser Gly Ser Ser Lys 
        355                 360                 365             


Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe 
    370                 375                 380                 


Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg 
385                 390                 395                 400 


Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys 
                405                 410                 415     


Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His 
            420                 425                 430         


Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys 
        435                 440                 445             


Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile 
    450                 455                 460                 


Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr 
465                 470                 475                 480 


Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe 
                485                 490                 495     


Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe 
            500                 505                 510         


Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser 
        515                 520                 525             


Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn 
    530                 535                 540                 


Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala 
545                 550                 555                 560 


Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn 
                565                 570                 575     


Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe 
            580                 585                 590         


Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly 
        595                 600                 605             


Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile 
    610                 615                 620                 


Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro 
625                 630                 635                 640 


Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly 
                645                 650                 655     


Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr 
            660                 665                 670         


Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys 
        675                 680                 685             


Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys 
    690                 695                 700                 


Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp 
705                 710                 715                 720 


Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu 
                725                 730                 735     


Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys 
            740                 745                 750         


Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr 
        755                 760                 765             


Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile 
    770                 775                 780                 


Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu 
785                 790                 795                 800 


Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala 
                805                 810                 815     


Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu 
            820                 825                 830         


Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp 
        835                 840                 845             


Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys 
    850                 855                 860                 


Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro 
865                 870                 875                 880 


Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met 
                885                 890                 895     


Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu 
            900                 905                 910         


Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala 
        915                 920                 925             


Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu 
    930                 935                 940                 


Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys 
945                 950                 955                 960 


Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp 
                965                 970                 975     


Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe 
            980                 985                 990         


Asn Leu Asn Asp Cys His Lys Leu  Ile Asp Phe Phe Lys  Asp Ser Ile 
        995                 1000                 1005             


Ser Arg  Tyr Pro Lys Trp Ser  Asn Ala Tyr Asp Phe  Asn Phe Ser 
    1010                 1015                 1020             


Glu Thr  Glu Lys Tyr Lys Asp  Ile Ala Gly Phe Tyr  Arg Glu Val 
    1025                 1030                 1035             


Glu Glu  Gln Gly Tyr Lys Val  Ser Phe Glu Ser Ala  Ser Lys Lys 
    1040                 1045                 1050             


Glu Val  Asp Lys Leu Val Glu  Glu Gly Lys Leu Tyr  Met Phe Gln 
    1055                 1060                 1065             


Ile Tyr  Asn Lys Asp Phe Ser  Asp Lys Ser His Gly  Thr Pro Asn 
    1070                 1075                 1080             


Leu His  Thr Met Tyr Phe Lys  Leu Leu Phe Asp Glu  Asn Asn His 
    1085                 1090                 1095             


Gly Gln  Ile Arg Leu Ser Gly  Gly Ala Glu Leu Phe  Met Arg Arg 
    1100                 1105                 1110             


Ala Ser  Leu Lys Lys Glu Glu  Leu Val Val His Pro  Ala Asn Ser 
    1115                 1120                 1125             


Pro Ile  Ala Asn Lys Asn Pro  Asp Asn Pro Lys Lys  Thr Thr Thr 
    1130                 1135                 1140             


Leu Ser  Tyr Asp Val Tyr Lys  Asp Lys Arg Phe Ser  Glu Asp Gln 
    1145                 1150                 1155             


Tyr Glu  Leu His Ile Pro Ile  Ala Ile Asn Lys Cys  Pro Lys Asn 
    1160                 1165                 1170             


Ile Phe  Lys Ile Asn Thr Glu  Val Arg Val Leu Leu  Lys His Asp 
    1175                 1180                 1185             


Asp Asn  Pro Tyr Val Ile Gly  Ile Asp Arg Gly Glu  Arg Asn Leu 
    1190                 1195                 1200             


Leu Tyr  Ile Val Val Val Asp  Gly Lys Gly Asn Ile  Val Glu Gln 
    1205                 1210                 1215             


Tyr Ser  Leu Asn Glu Ile Ile  Asn Asn Phe Asn Gly  Ile Arg Ile 
    1220                 1225                 1230             


Lys Thr  Asp Tyr His Ser Leu  Leu Asp Lys Lys Glu  Lys Glu Arg 
    1235                 1240                 1245             


Phe Glu  Ala Arg Gln Asn Trp  Thr Ser Ile Glu Asn  Ile Lys Glu 
    1250                 1255                 1260             


Leu Lys  Ala Gly Tyr Ile Ser  Gln Val Val His Lys  Ile Cys Glu 
    1265                 1270                 1275             


Leu Val  Glu Lys Tyr Asp Ala  Val Ile Ala Leu Glu  Asp Leu Asn 
    1280                 1285                 1290             


Ser Gly  Phe Lys Asn Ser Arg  Val Lys Val Glu Lys  Gln Val Tyr 
    1295                 1300                 1305             


Gln Lys  Phe Glu Lys Met Leu  Ile Asp Lys Leu Asn  Tyr Met Val 
    1310                 1315                 1320             


Asp Lys  Lys Ser Asn Pro Cys  Ala Thr Gly Gly Ala  Leu Lys Gly 
    1325                 1330                 1335             


Tyr Gln  Ile Thr Asn Lys Phe  Glu Ser Phe Lys Ser  Met Ser Thr 
    1340                 1345                 1350             


Gln Asn  Gly Phe Ile Phe Tyr  Ile Pro Ala Trp Leu  Thr Ser Lys 
    1355                 1360                 1365             


Ile Asp  Pro Ser Thr Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr 
    1370                 1375                 1380             


Thr Ser  Ile Ala Asp Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg 
    1385                 1390                 1395             


Ile Met  Tyr Val Pro Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp 
    1400                 1405                 1410             


Tyr Lys  Asn Phe Ser Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp 
    1415                 1420                 1425             


Lys Leu  Tyr Ser Tyr Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro 
    1430                 1435                 1440             


Lys Lys  Asn Asn Val Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser 
    1445                 1450                 1455             


Ala Tyr  Lys Glu Leu Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln 
    1460                 1465                 1470             


Gly Asp  Ile Arg Ala Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe 
    1475                 1480                 1485             


Tyr Ser  Ser Phe Met Ala Leu  Met Ser Leu Met Leu  Gln Met Arg 
    1490                 1495                 1500             


Asn Ser  Ile Thr Gly Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro 
    1505                 1510                 1515             


Val Lys  Asn Ser Asp Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu 
    1520                 1525                 1530             


Ala Gln  Glu Asn Ala Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly 
    1535                 1540                 1545             


Ala Tyr  Asn Ile Ala Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe 
    1550                 1555                 1560             


Lys Lys  Ala Glu Asp Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile 
    1565                 1570                 1575             


Ser Asn  Lys Glu Trp Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1580                 1585                 1590             


<210>  174
<211>  1507
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic scFV::Cas12a fusion

<400>  174

Met Ala Gly Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
1               5                   10                  15      


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly 
            20                  25                  30          


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly 
        35                  40                  45              


Lys Leu Phe Lys Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
    50                  55                  60                  


Val Pro Ser Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu 
            100                 105                 110         


Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ser Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly 
    130                 135                 140                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser 
145                 150                 155                 160 


Gly Phe Ser Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro 
                165                 170                 175     


Gly Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr 
            180                 185                 190         


Asp Tyr Asn Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asn 
        195                 200                 205             


Gly Lys Asn Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp 
    210                 215                 220                 


Thr Ala Leu Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Tyr Pro Tyr Asp Val Pro Asp Tyr 
                245                 250                 255     


Ala Gly Ser Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
            260                 265                 270         


Gly Gly Ser Gly Gly Ser Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn 
        275                 280                 285             


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
    290                 295                 300                 


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
305                 310                 315                 320 


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
                325                 330                 335     


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
            340                 345                 350         


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
        355                 360                 365             


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
    370                 375                 380                 


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
385                 390                 395                 400 


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
                405                 410                 415     


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
            420                 425                 430         


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
        435                 440                 445             


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
    450                 455                 460                 


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
465                 470                 475                 480 


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
                485                 490                 495     


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
            500                 505                 510         


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
        515                 520                 525             


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
    530                 535                 540                 


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
545                 550                 555                 560 


Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp 
                565                 570                 575     


Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu 
            580                 585                 590         


Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp 
        595                 600                 605             


Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser 
    610                 615                 620                 


Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys 
625                 630                 635                 640 


Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val 
                645                 650                 655     


Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly 
            660                 665                 670         


Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser 
        675                 680                 685             


Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile 
    690                 695                 700                 


Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val 
705                 710                 715                 720 


Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys 
                725                 730                 735     


Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe 
            740                 745                 750         


Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp 
        755                 760                 765             


Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp 
    770                 775                 780                 


Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe 
785                 790                 795                 800 


Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp 
                805                 810                 815     


Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr 
            820                 825                 830         


Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile 
        835                 840                 845             


Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu 
    850                 855                 860                 


Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys 
865                 870                 875                 880 


Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys 
                885                 890                 895     


Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His 
            900                 905                 910         


Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp 
        915                 920                 925             


Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp 
    930                 935                 940                 


Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser 
945                 950                 955                 960 


Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly 
                965                 970                 975     


Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser 
            980                 985                 990         


His Gly Thr Pro Asn Leu His Thr  Met Tyr Phe Lys Leu  Leu Phe Asp 
        995                 1000                 1005             


Glu Asn  Asn His Gly Gln Ile  Arg Leu Ser Gly Gly  Ala Glu Leu 
    1010                 1015                 1020             


Phe Met  Arg Arg Ala Ser Leu  Lys Lys Glu Glu Leu  Val Val His 
    1025                 1030                 1035             


Pro Ala  Asn Ser Pro Ile Ala  Asn Lys Asn Pro Asp  Asn Pro Lys 
    1040                 1045                 1050             


Lys Thr  Thr Thr Leu Ser Tyr  Asp Val Tyr Lys Asp  Lys Arg Phe 
    1055                 1060                 1065             


Ser Glu  Asp Gln Tyr Glu Leu  His Ile Pro Ile Ala  Ile Asn Lys 
    1070                 1075                 1080             


Cys Pro  Lys Asn Ile Phe Lys  Ile Asn Thr Glu Val  Arg Val Leu 
    1085                 1090                 1095             


Leu Lys  His Asp Asp Asn Pro  Tyr Val Ile Gly Ile  Asp Arg Gly 
    1100                 1105                 1110             


Glu Arg  Asn Leu Leu Tyr Ile  Val Val Val Asp Gly  Lys Gly Asn 
    1115                 1120                 1125             


Ile Val  Glu Gln Tyr Ser Leu  Asn Glu Ile Ile Asn  Asn Phe Asn 
    1130                 1135                 1140             


Gly Ile  Arg Ile Lys Thr Asp  Tyr His Ser Leu Leu  Asp Lys Lys 
    1145                 1150                 1155             


Glu Lys  Glu Arg Phe Glu Ala  Arg Gln Asn Trp Thr  Ser Ile Glu 
    1160                 1165                 1170             


Asn Ile  Lys Glu Leu Lys Ala  Gly Tyr Ile Ser Gln  Val Val His 
    1175                 1180                 1185             


Lys Ile  Cys Glu Leu Val Glu  Lys Tyr Asp Ala Val  Ile Ala Leu 
    1190                 1195                 1200             


Glu Asp  Leu Asn Ser Gly Phe  Lys Asn Ser Arg Val  Lys Val Glu 
    1205                 1210                 1215             


Lys Gln  Val Tyr Gln Lys Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1220                 1225                 1230             


Asn Tyr  Met Val Asp Lys Lys  Ser Asn Pro Cys Ala  Thr Gly Gly 
    1235                 1240                 1245             


Ala Leu  Lys Gly Tyr Gln Ile  Thr Asn Lys Phe Glu  Ser Phe Lys 
    1250                 1255                 1260             


Ser Met  Ser Thr Gln Asn Gly  Phe Ile Phe Tyr Ile  Pro Ala Trp 
    1265                 1270                 1275             


Leu Thr  Ser Lys Ile Asp Pro  Ser Thr Gly Phe Val  Asn Leu Leu 
    1280                 1285                 1290             


Lys Thr  Lys Tyr Thr Ser Ile  Ala Asp Ser Lys Lys  Phe Ile Ser 
    1295                 1300                 1305             


Ser Phe  Asp Arg Ile Met Tyr  Val Pro Glu Glu Asp  Leu Phe Glu 
    1310                 1315                 1320             


Phe Ala  Leu Asp Tyr Lys Asn  Phe Ser Arg Thr Asp  Ala Asp Tyr 
    1325                 1330                 1335             


Ile Lys  Lys Trp Lys Leu Tyr  Ser Tyr Gly Asn Arg  Ile Arg Ile 
    1340                 1345                 1350             


Phe Arg  Asn Pro Lys Lys Asn  Asn Val Phe Asp Trp  Glu Glu Val 
    1355                 1360                 1365             


Cys Leu  Thr Ser Ala Tyr Lys  Glu Leu Phe Asn Lys  Tyr Gly Ile 
    1370                 1375                 1380             


Asn Tyr  Gln Gln Gly Asp Ile  Arg Ala Leu Leu Cys  Glu Gln Ser 
    1385                 1390                 1395             


Asp Lys  Ala Phe Tyr Ser Ser  Phe Met Ala Leu Met  Ser Leu Met 
    1400                 1405                 1410             


Leu Gln  Met Arg Asn Ser Ile  Thr Gly Arg Thr Asp  Val Asp Phe 
    1415                 1420                 1425             


Leu Ile  Ser Pro Val Lys Asn  Ser Asp Gly Ile Phe  Tyr Asp Ser 
    1430                 1435                 1440             


Arg Asn  Tyr Glu Ala Gln Glu  Asn Ala Ile Leu Pro  Lys Asn Ala 
    1445                 1450                 1455             


Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg Lys Val  Leu Trp Ala 
    1460                 1465                 1470             


Ile Gly  Gln Phe Lys Lys Ala  Glu Asp Glu Lys Leu  Asp Lys Val 
    1475                 1480                 1485             


Lys Ile  Ala Ile Ser Asn Lys  Glu Trp Leu Glu Tyr  Ala Gln Thr 
    1490                 1495                 1500             


Ser Val  Lys His 
    1505         


<210>  175
<211>  828
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::8xGCN4 fusion

<400>  175

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ser Gly 
    370                 375                 380                 


Ser Lys Lys Arg Arg Ile Lys Gln Asp Glu Glu Leu Leu Ser Lys Asn 
385                 390                 395                 400 


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
                405                 410                 415     


Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly 
            420                 425                 430         


Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His 
        435                 440                 445             


Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly 
    450                 455                 460                 


Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu 
                485                 490                 495     


Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly 
            500                 505                 510         


Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser 
        515                 520                 525             


Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu 
    530                 535                 540                 


Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
545                 550                 555                 560 


Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser 
                565                 570                 575     


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
            580                 585                 590         


Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser 
        595                 600                 605             


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu 
    610                 615                 620                 


Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu 
625                 630                 635                 640 


Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser 
                645                 650                 655     


Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu 
            660                 665                 670         


Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys 
        675                 680                 685             


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser 
    690                 695                 700                 


Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser 
705                 710                 715                 720 


Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser 
                725                 730                 735     


Lys Lys Arg Arg Ile Lys Gln Asp Ser Gly Ser Gly Gly Ser Ser Gly 
            740                 745                 750         


Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser Arg Pro Ser 
        755                 760                 765             


Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp Ser Leu Ser 
    770                 775                 780                 


Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser Lys Arg Pro 
785                 790                 795                 800 


Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg Glu Arg Asp 
                805                 810                 815     


Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg 
            820                 825             


<210>  176
<211>  1593
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Cas12a::8xGCN4 fusion

<400>  176

Met Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Gly  Ser Ser Glu 
    1220                 1225                 1230             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Gly  Gly Ser Gly 
    1235                 1240                 1245             


Gly Ser  Gly Ser Glu Glu Leu  Leu Ser Lys Asn Tyr  His Leu Glu 
    1250                 1255                 1260             


Asn Glu  Val Ala Arg Leu Lys  Lys Gly Ser Gly Ser  Gly Gly Ser 
    1265                 1270                 1275             


Gly Ser  Gly Gly Ser Gly Ser  Gly Ser Gly Gly Ser  Gly Ser Gly 
    1280                 1285                 1290             


Gly Ser  Gly Ser Gly Glu Glu  Leu Leu Ser Lys Asn  Tyr His Leu 
    1295                 1300                 1305             


Glu Asn  Glu Val Ala Arg Leu  Lys Lys Gly Ser Gly  Ser Gly Gly 
    1310                 1315                 1320             


Ser Gly  Ser Gly Gly Ser Gly  Ser Gly Ser Gly Gly  Ser Gly Ser 
    1325                 1330                 1335             


Gly Gly  Ser Gly Ser Gly Glu  Glu Leu Leu Ser Lys  Asn Tyr His 
    1340                 1345                 1350             


Leu Glu  Asn Glu Val Ala Arg  Leu Lys Lys Gly Ser  Gly Ser Gly 
    1355                 1360                 1365             


Gly Ser  Gly Ser Gly Gly Ser  Gly Ser Gly Ser Gly  Gly Ser Gly 
    1370                 1375                 1380             


Ser Gly  Gly Ser Gly Ser Gly  Glu Glu Leu Leu Ser  Lys Asn Tyr 
    1385                 1390                 1395             


His Leu  Glu Asn Glu Val Ala  Arg Leu Lys Lys Gly  Ser Gly Ser 
    1400                 1405                 1410             


Gly Gly  Ser Gly Ser Gly Gly  Ser Gly Ser Gly Ser  Gly Gly Ser 
    1415                 1420                 1425             


Gly Ser  Gly Gly Ser Gly Ser  Gly Glu Glu Leu Leu  Ser Lys Asn 
    1430                 1435                 1440             


Tyr His  Leu Glu Asn Glu Val  Ala Arg Leu Lys Lys  Gly Ser Gly 
    1445                 1450                 1455             


Ser Gly  Gly Ser Gly Ser Gly  Gly Ser Gly Ser Gly  Ser Gly Gly 
    1460                 1465                 1470             


Ser Gly  Ser Gly Gly Ser Gly  Ser Gly Glu Glu Leu  Leu Ser Lys 
    1475                 1480                 1485             


Asn Tyr  His Leu Glu Asn Glu  Val Ala Arg Leu Lys  Lys Gly Ser 
    1490                 1495                 1500             


Gly Ser  Gly Gly Ser Gly Ser  Gly Gly Ser Gly Ser  Gly Ser Gly 
    1505                 1510                 1515             


Gly Ser  Gly Ser Gly Gly Ser  Gly Ser Gly Glu Glu  Leu Leu Ser 
    1520                 1525                 1530             


Lys Asn  Tyr His Leu Glu Asn  Glu Val Ala Arg Leu  Lys Lys Gly 
    1535                 1540                 1545             


Ser Gly  Ser Gly Gly Ser Gly  Ser Gly Gly Ser Gly  Ser Gly Ser 
    1550                 1555                 1560             


Gly Gly  Ser Gly Ser Gly Gly  Ser Gly Ser Gly Glu  Glu Leu Leu 
    1565                 1570                 1575             


Ser Lys  Asn Tyr His Leu Glu  Asn Glu Val Ala Arg  Leu Lys Lys 
    1580                 1585                 1590             


<210>  177
<211>  756
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic scFv::VirD2 fusion

<400>  177

Met Ser Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Gly Pro Asp Ile 
1               5                   10                  15      


Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            20                  25                  30          


Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn 
        35                  40                  45              


Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys Leu Phe Lys Gly Leu 
    50                  55                  60                  


Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ser Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr Ile Ser Ser Leu Gln 
                85                  90                  95      


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His 
            100                 105                 110         


Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Asp 
                165                 170                 175     


Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Asp Arg Phe Ile Ile Ser Lys Asp Asn Gly Lys Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys 
225                 230                 235                 240 


Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Lys Lys Arg 
            260                 265                 270         


Arg Ile Lys Gln Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser 
        275                 280                 285             


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly 
    290                 295                 300                 


Ser Ser Gly Gly Ser Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile 
305                 310                 315                 320 


Val Pro Gly Gly Gly Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu 
                325                 330                 335     


Glu Tyr Leu Ser Arg Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg 
            340                 345                 350         


His Leu Asp Ile Pro Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg 
        355                 360                 365             


Ser Trp Val Gln Glu Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu 
    370                 375                 380                 


Glu Arg Gln Gln Glu Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala 
385                 390                 395                 400 


Gly Thr Ser Gln Val Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala 
                405                 410                 415     


Glu Met Phe Gly Ser Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr 
            420                 425                 430         


Ala Phe His Ile Asp Arg Asp His Pro His Leu His Val Val Val Asn 
        435                 440                 445             


Arg Arg Glu Leu Leu Gly His Gly Trp Leu Lys Ile Ser Arg Arg His 
    450                 455                 460                 


Pro Gln Leu Asn Tyr Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser 
465                 470                 475                 480 


Leu Arg His Gly Ile Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly 
                485                 490                 495     


Ile Thr Glu Arg Pro Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg 
            500                 505                 510         


Glu Gln Ala Arg Gln Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser 
        515                 520                 525             


Ser Pro Gln Gly Asp His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser 
    530                 535                 540                 


Pro Phe Glu Ala Ser Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn 
545                 550                 555                 560 


Asn Arg Gln Asn Glu Ser Gln Val His Leu Gln Glu Pro Ala Gly Val 
                565                 570                 575     


Ser Asn Glu Ala Gly Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg 
            580                 585                 590         


Leu Ala Gln Pro Phe Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly 
        595                 600                 605             


Ser Gly Ser Ser Arg Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg 
    610                 615                 620                 


Thr Pro Asp Ile Pro Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr 
625                 630                 635                 640 


His Asp Arg Gln Arg Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly 
                645                 650                 655     


Pro Ser Gly Ala Lys Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro 
            660                 665                 670         


Gln Ala Asn Ala Gly Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg 
        675                 680                 685             


Gln Ala Gly Thr Ser Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala 
    690                 695                 700                 


Ser Thr Ala Thr Asp Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg 
705                 710                 715                 720 


Arg Gly Val Leu Ser Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro 
                725                 730                 735     


Ser Glu Arg Lys Arg Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly 
            740                 745                 750         


Gly Asn Arg Arg 
        755     


<210>  178
<211>  842
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic 8xGCN4::VirD2 fusion

<400>  178

Met Ser Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Glu Glu Leu Leu 
1               5                   10                  15      


Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly 
            20                  25                  30          


Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly 
        35                  40                  45              


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys 
    50                  55                  60                  


Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser 
                85                  90                  95      


Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr 
            100                 105                 110         


His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser 
    130                 135                 140                 


Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu 
145                 150                 155                 160 


Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser 
                165                 170                 175     


Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly 
            180                 185                 190         


Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn 
        195                 200                 205             


Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser 
    210                 215                 220                 


Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
225                 230                 235                 240 


Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val 
                245                 250                 255     


Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly 
            260                 265                 270         


Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
        275                 280                 285             


Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
    290                 295                 300                 


Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu 
                325                 330                 335     


Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
            340                 345                 350         


Lys Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Ser Gly Gly Ser Ser 
        355                 360                 365             


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
    370                 375                 380                 


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Pro Asp Arg Ala 
385                 390                 395                 400 


Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly Thr Lys Thr Leu Gln 
                405                 410                 415     


Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg Lys Gly Arg Leu Glu 
            420                 425                 430         


Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro Leu Pro Pro Asp Gln 
        435                 440                 445             


Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu Thr Gly Thr Tyr Asp 
    450                 455                 460                 


Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu Leu Thr Thr His Ile 
465                 470                 475                 480 


Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val Ala Ala Tyr Ala Ala 
                485                 490                 495     


Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser Gly Ala Gly Gly Gly 
            500                 505                 510         


Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp Arg Asp His Pro His 
        515                 520                 525             


Leu His Val Val Val Asn Arg Arg Glu Leu Leu Gly His Gly Trp Leu 
    530                 535                 540                 


Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr Asp Ala Leu Arg Ile 
545                 550                 555                 560 


Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile Ala Leu Asp Ala Ser 
                565                 570                 575     


Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro Ile Thr Tyr Ala Gln 
            580                 585                 590         


Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln Ile Arg Phe Glu Asp 
        595                 600                 605             


Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp His Pro Glu Phe Ser 
    610                 615                 620                 


Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser Ala Gly Gly Pro Glu 
625                 630                 635                 640 


Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu Ser Gln Val His Leu 
                645                 650                 655     


Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly Val Leu Val Arg Val 
            660                 665                 670         


Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe Val Ser Glu Thr Ile 
        675                 680                 685             


Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg Val Ala Glu Gly Arg 
    690                 695                 700                 


Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro Arg Ala Ala Thr Glu 
705                 710                 715                 720 


Ala Ala Thr His Thr Thr His Asp Arg Gln Arg Arg Ala Lys Arg Pro 
                725                 730                 735     


His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys Arg Val Thr Leu Glu 
            740                 745                 750         


Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly Glu Gln Asp Gly Ser 
        755                 760                 765             


Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser Arg Pro Ser Pro Pro 
    770                 775                 780                 


Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp Ser Leu Ser Ala Thr 
785                 790                 795                 800 


Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser Lys Arg Pro Arg Glu 
                805                 810                 815     


Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg Glu Arg Asp Glu Arg 
            820                 825                 830         


Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg 
        835                 840         


<210>  179
<211>  1507
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Cas12a::scFV fusion

<400>  179

Met Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Gly  Ser Ser Glu 
    1220                 1225                 1230             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Gly  Gly Ser Gly 
    1235                 1240                 1245             


Gly Ser  Gly Ser Gly Pro Asp  Ile Val Met Thr Gln  Ser Pro Ser 
    1250                 1255                 1260             


Ser Leu  Ser Ala Ser Val Gly  Asp Arg Val Thr Ile  Thr Cys Arg 
    1265                 1270                 1275             


Ser Ser  Thr Gly Ala Val Thr  Thr Ser Asn Tyr Ala  Ser Trp Val 
    1280                 1285                 1290             


Gln Glu  Lys Pro Gly Lys Leu  Phe Lys Gly Leu Ile  Gly Gly Thr 
    1295                 1300                 1305             


Asn Asn  Arg Ala Pro Gly Val  Pro Ser Arg Phe Ser  Gly Ser Leu 
    1310                 1315                 1320             


Ile Gly  Asp Lys Ala Thr Leu  Thr Ile Ser Ser Leu  Gln Pro Glu 
    1325                 1330                 1335             


Asp Phe  Ala Thr Tyr Phe Cys  Ala Leu Trp Tyr Ser  Asn His Trp 
    1340                 1345                 1350             


Val Phe  Gly Gln Gly Thr Lys  Val Glu Leu Lys Arg  Gly Gly Gly 
    1355                 1360                 1365             


Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Ser Gly Gly 
    1370                 1375                 1380             


Gly Ser  Glu Val Lys Leu Leu  Glu Ser Gly Gly Gly  Leu Val Gln 
    1385                 1390                 1395             


Pro Gly  Gly Ser Leu Lys Leu  Ser Cys Ala Val Ser  Gly Phe Ser 
    1400                 1405                 1410             


Leu Thr  Asp Tyr Gly Val Asn  Trp Val Arg Gln Ala  Pro Gly Arg 
    1415                 1420                 1425             


Gly Leu  Glu Trp Ile Gly Val  Ile Trp Gly Asp Gly  Ile Thr Asp 
    1430                 1435                 1440             


Tyr Asn  Ser Ala Leu Lys Asp  Arg Phe Ile Ile Ser  Lys Asp Asn 
    1445                 1450                 1455             


Gly Lys  Asn Thr Val Tyr Leu  Gln Met Ser Lys Val  Arg Ser Asp 
    1460                 1465                 1470             


Asp Thr  Ala Leu Tyr Tyr Cys  Val Thr Gly Leu Phe  Asp Tyr Trp 
    1475                 1480                 1485             


Gly Gln  Gly Thr Leu Val Thr  Val Ser Ser Tyr Pro  Tyr Asp Val 
    1490                 1495                 1500             


Pro Asp  Tyr Ala 
    1505         


<210>  180
<211>  790
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2-ScFv-VirF fusion

<400>  180

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser 
    370                 375                 380                 


Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp 
385                 390                 395                 400 


Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser 
                405                 410                 415     


Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg 
            420                 425                 430         


Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg Ser 
        435                 440                 445             


Gly Gly Ser Ser Gly Gly Ser Met Ser Gly Ser Lys Lys Arg Arg Ile 
    450                 455                 460                 


Lys Gln Asp Gly Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
465                 470                 475                 480 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr 
                485                 490                 495     


Gly Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro 
            500                 505                 510         


Gly Lys Leu Phe Lys Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro 
        515                 520                 525             


Gly Val Pro Ser Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr 
    530                 535                 540                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys 
545                 550                 555                 560 


Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gln Gly Thr Lys Val 
                565                 570                 575     


Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly 
        595                 600                 605             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val 
    610                 615                 620                 


Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala 
625                 630                 635                 640 


Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Ile 
                645                 650                 655     


Thr Asp Tyr Asn Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp 
            660                 665                 670         


Asn Gly Lys Asn Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp 
        675                 680                 685             


Asp Thr Ala Leu Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly 
    690                 695                 700                 


Gln Gly Thr Leu Val Thr Val Ser Ser Tyr Pro Tyr Asp Val Pro Asp 
705                 710                 715                 720 


Tyr Ala Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Ser Gly Gly Ser 
                725                 730                 735     


Ser Gly Gly Ser Ser Ala Ser Leu Ala Arg Gly Gly Pro Asn Ala Val 
            740                 745                 750         


Gly Leu Leu Thr Thr Asn Glu Ser Phe Glu Lys Asn Ile Asn Glu Val 
        755                 760                 765             


Tyr Asn Arg Thr Arg Ala Glu Leu Asp Ala Ser Ser Arg Asp Arg Ser 
    770                 775                 780                 


Arg Ser Gly Leu Ser Arg 
785                 790 


<210>  181
<211>  876
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::8xGCN4::VirF  fusion

<400>  181

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser 
    370                 375                 380                 


Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp 
385                 390                 395                 400 


Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser 
                405                 410                 415     


Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg 
            420                 425                 430         


Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg Ser 
        435                 440                 445             


Gly Gly Ser Ser Gly Gly Ser Met Ser Gly Ser Lys Lys Arg Arg Ile 
    450                 455                 460                 


Lys Gln Asp Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu 
465                 470                 475                 480 


Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
                485                 490                 495     


Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser 
            500                 505                 510         


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
        515                 520                 525             


Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser 
    530                 535                 540                 


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu 
545                 550                 555                 560 


Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu 
                565                 570                 575     


Lys Lys Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser 
            580                 585                 590         


Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu 
        595                 600                 605             


Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys 
    610                 615                 620                 


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser 
625                 630                 635                 640 


Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser 
                645                 650                 655     


Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser 
            660                 665                 670         


Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly 
        675                 680                 685             


Ser Gly Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
    690                 695                 700                 


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
705                 710                 715                 720 


Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly 
                725                 730                 735     


Ser Gly Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His 
            740                 745                 750         


Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser Gly Gly 
        755                 760                 765             


Ser Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
    770                 775                 780                 


Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu 
785                 790                 795                 800 


Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Lys Lys Arg Arg Ile Lys 
                805                 810                 815     


Gln Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Ala Ser Leu Ala Arg 
            820                 825                 830         


Gly Gly Pro Asn Ala Val Gly Leu Leu Thr Thr Asn Glu Ser Phe Glu 
        835                 840                 845             


Lys Asn Ile Asn Glu Val Tyr Asn Arg Thr Arg Ala Glu Leu Asp Ala 
    850                 855                 860                 


Ser Ser Arg Asp Arg Ser Arg Ser Gly Leu Ser Arg 
865                 870                 875     


<210>  182
<211>  548
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SH3dom::VirD2 fusion

<400>  182

Met Ser Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Ala Glu Tyr Val 
1               5                   10                  15      


Arg Ala Leu Phe Asp Phe Asn Gly Asn Asp Glu Glu Asp Leu Pro Phe 
            20                  25                  30          


Lys Lys Gly Asp Ile Leu Arg Ile Arg Asp Lys Pro Glu Glu Gln Trp 
        35                  40                  45              


Trp Asn Ala Glu Asp Ser Glu Gly Lys Arg Gly Met Ile Pro Val Pro 
    50                  55                  60                  


Tyr Val Glu Lys Tyr Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser 
65                  70                  75                  80  


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly 
                85                  90                  95      


Ser Ser Gly Gly Ser Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile 
            100                 105                 110         


Val Pro Gly Gly Gly Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu 
        115                 120                 125             


Glu Tyr Leu Ser Arg Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg 
    130                 135                 140                 


His Leu Asp Ile Pro Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg 
145                 150                 155                 160 


Ser Trp Val Gln Glu Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu 
                165                 170                 175     


Glu Arg Gln Gln Glu Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala 
            180                 185                 190         


Gly Thr Ser Gln Val Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala 
        195                 200                 205             


Glu Met Phe Gly Ser Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr 
    210                 215                 220                 


Ala Phe His Ile Asp Arg Asp His Pro His Leu His Val Val Val Asn 
225                 230                 235                 240 


Arg Arg Glu Leu Leu Gly His Gly Trp Leu Lys Ile Ser Arg Arg His 
                245                 250                 255     


Pro Gln Leu Asn Tyr Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser 
            260                 265                 270         


Leu Arg His Gly Ile Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly 
        275                 280                 285             


Ile Thr Glu Arg Pro Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg 
    290                 295                 300                 


Glu Gln Ala Arg Gln Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser 
305                 310                 315                 320 


Ser Pro Gln Gly Asp His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser 
                325                 330                 335     


Pro Phe Glu Ala Ser Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn 
            340                 345                 350         


Asn Arg Gln Asn Glu Ser Gln Val His Leu Gln Glu Pro Ala Gly Val 
        355                 360                 365             


Ser Asn Glu Ala Gly Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg 
    370                 375                 380                 


Leu Ala Gln Pro Phe Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly 
385                 390                 395                 400 


Ser Gly Ser Ser Arg Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg 
                405                 410                 415     


Thr Pro Asp Ile Pro Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr 
            420                 425                 430         


His Asp Arg Gln Arg Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly 
        435                 440                 445             


Pro Ser Gly Ala Lys Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro 
    450                 455                 460                 


Gln Ala Asn Ala Gly Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg 
465                 470                 475                 480 


Gln Ala Gly Thr Ser Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala 
                485                 490                 495     


Ser Thr Ala Thr Asp Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg 
            500                 505                 510         


Arg Gly Val Leu Ser Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro 
        515                 520                 525             


Ser Glu Arg Lys Arg Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly 
    530                 535                 540                 


Gly Asn Arg Arg 
545             


<210>  183
<211>  1320
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Cas12a::4xSH3lig fusion

<400>  183

Met Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Gly  Ser Ser Glu 
    1220                 1225                 1230             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Gly  Gly Ser Gly 
    1235                 1240                 1245             


Gly Ser  Gly Ser Pro Pro Pro  Ala Leu Pro Pro Lys  Arg Arg Arg 
    1250                 1255                 1260             


Ser Gly  Gly Ser Ser Gly Gly  Ser Pro Pro Pro Ala  Leu Pro Pro 
    1265                 1270                 1275             


Lys Arg  Arg Arg Ser Gly Gly  Ser Ser Gly Gly Ser  Pro Pro Pro 
    1280                 1285                 1290             


Ala Leu  Pro Pro Lys Arg Arg  Arg Ser Gly Gly Ser  Ser Gly Gly 
    1295                 1300                 1305             


Ser Pro  Pro Pro Ala Leu Pro  Pro Lys Arg Arg Arg  
    1310                 1315                 1320 


<210>  184
<211>  559
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic 4xSH3lig::VirD2 fusion

<400>  184

Met Ser Gly Ser Lys Lys Arg Arg Ile Lys Gln Asp Pro Pro Pro Ala 
1               5                   10                  15      


Leu Pro Pro Lys Arg Arg Arg Ser Gly Gly Ser Ser Gly Gly Ser Pro 
            20                  25                  30          


Pro Pro Ala Leu Pro Pro Lys Arg Arg Arg Ser Gly Gly Ser Ser Gly 
        35                  40                  45              


Gly Ser Pro Pro Pro Ala Leu Pro Pro Lys Arg Arg Arg Ser Gly Gly 
    50                  55                  60                  


Ser Ser Gly Gly Ser Pro Pro Pro Ala Leu Pro Pro Lys Arg Arg Arg 
65                  70                  75                  80  


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
                85                  90                  95      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            100                 105                 110         


Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
        115                 120                 125             


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
    130                 135                 140                 


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
145                 150                 155                 160 


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
                165                 170                 175     


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
            180                 185                 190         


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
        195                 200                 205             


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
    210                 215                 220                 


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
225                 230                 235                 240 


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
                245                 250                 255     


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
            260                 265                 270         


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
        275                 280                 285             


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
    290                 295                 300                 


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
305                 310                 315                 320 


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
                325                 330                 335     


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
            340                 345                 350         


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
        355                 360                 365             


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
    370                 375                 380                 


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
385                 390                 395                 400 


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
                405                 410                 415     


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
            420                 425                 430         


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
        435                 440                 445             


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
    450                 455                 460                 


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
465                 470                 475                 480 


Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser 
                485                 490                 495     


Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp 
            500                 505                 510         


Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser 
        515                 520                 525             


Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg 
    530                 535                 540                 


Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg 
545                 550                 555                 


<210>  185
<211>  1309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Cas12a::SH3dom fusion

<400>  185

Met Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Gly  Ser Ser Glu 
    1220                 1225                 1230             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Gly  Gly Ser Gly 
    1235                 1240                 1245             


Gly Ser  Gly Ser Ala Glu Tyr  Val Arg Ala Leu Phe  Asp Phe Asn 
    1250                 1255                 1260             


Gly Asn  Asp Glu Glu Asp Leu  Pro Phe Lys Lys Gly  Asp Ile Leu 
    1265                 1270                 1275             


Arg Ile  Arg Asp Lys Pro Glu  Glu Gln Trp Trp Asn  Ala Glu Asp 
    1280                 1285                 1290             


Ser Glu  Gly Lys Arg Gly Met  Ile Pro Val Pro Tyr  Val Glu Lys 
    1295                 1300                 1305             


Tyr 
    


<210>  186
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::SH3dom fusion

<400>  186

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ser Gly 
    370                 375                 380                 


Ser Lys Lys Arg Arg Ile Lys Gln Asp Ala Glu Tyr Val Arg Ala Leu 
385                 390                 395                 400 


Phe Asp Phe Asn Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly 
                405                 410                 415     


Asp Ile Leu Arg Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala 
            420                 425                 430         


Glu Asp Ser Glu Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu 
        435                 440                 445             


Lys Tyr Ser Gly Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Pro Leu 
    450                 455                 460                 


Val Arg Gln Ala Gly Thr Ser Arg Pro Ser Pro Pro Thr Ala Thr Thr 
465                 470                 475                 480 


Arg Ala Ser Thr Ala Thr Asp Ser Leu Ser Ala Thr Ala His Leu Gln 
                485                 490                 495     


Gln Arg Arg Gly Val Leu Ser Lys Arg Pro Arg Glu Asp Asp Asp Gly 
            500                 505                 510         


Glu Pro Ser Glu Arg Lys Arg Glu Arg Asp Glu Arg Ser Lys Asp Gly 
        515                 520                 525             


Arg Gly Gly Asn Arg Arg 
    530                 


<210>  187
<211>  1320
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic 4xSH3lig::Cas12a fusion

<400>  187

Met Ala Pro Pro Pro Ala Leu Pro Pro Lys Arg Arg Arg Ser Gly Gly 
1               5                   10                  15      


Ser Ser Gly Gly Ser Pro Pro Pro Ala Leu Pro Pro Lys Arg Arg Arg 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser Pro Pro Pro Ala Leu Pro Pro Lys 
        35                  40                  45              


Arg Arg Arg Ser Gly Gly Ser Ser Gly Gly Ser Pro Pro Pro Ala Leu 
    50                  55                  60                  


Pro Pro Lys Arg Arg Arg Gly Ser Ser Glu Thr Pro Gly Thr Ser Glu 
65                  70                  75                  80  


Ser Ala Thr Pro Glu Gly Gly Ser Gly Gly Ser Gly Ser Ser Lys Leu 
                85                  90                  95      


Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys 
            100                 105                 110         


Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu 
        115                 120                 125             


Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys 
    130                 135                 140                 


Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser 
145                 150                 155                 160 


Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys 
                165                 170                 175     


Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn 
            180                 185                 190         


Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys 
        195                 200                 205             


Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu 
    210                 215                 220                 


Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu 
                245                 250                 255     


Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu 
            260                 265                 270         


Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile 
        275                 280                 285             


Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser 
    290                 295                 300                 


Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val 
305                 310                 315                 320 


Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe 
                325                 330                 335     


Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn 
            340                 345                 350         


Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu 
        355                 360                 365             


Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu 
    370                 375                 380                 


Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu 
385                 390                 395                 400 


Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu 
                405                 410                 415     


Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn 
            420                 425                 430         


Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn 
        435                 440                 445             


Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys 
    450                 455                 460                 


Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser 
465                 470                 475                 480 


Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala 
                485                 490                 495     


Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln 
            500                 505                 510         


Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe 
        515                 520                 525             


Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val 
    530                 535                 540                 


Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn 
545                 550                 555                 560 


Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu 
                565                 570                 575     


Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val 
            580                 585                 590         


Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr 
        595                 600                 605             


Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly 
    610                 615                 620                 


Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg 
625                 630                 635                 640 


Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys 
                645                 650                 655     


Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys 
            660                 665                 670         


Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val 
        675                 680                 685             


Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile 
    690                 695                 700                 


Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn 
705                 710                 715                 720 


Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser 
                725                 730                 735     


Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr 
            740                 745                 750         


Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln 
        755                 760                 765             


Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys 
    770                 775                 780                 


Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp 
785                 790                 795                 800 


Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe 
                805                 810                 815     


Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg Leu Ser Gly 
            820                 825                 830         


Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu 
        835                 840                 845             


Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn 
    850                 855                 860                 


Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr Lys Asp Lys Arg 
865                 870                 875                 880 


Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile Ala Ile Asn Lys 
                885                 890                 895     


Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val Arg Val Leu Leu 
            900                 905                 910         


Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg 
        915                 920                 925             


Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly Asn Ile Val Glu 
    930                 935                 940                 


Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn Gly Ile Arg Ile 
945                 950                 955                 960 


Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe 
                965                 970                 975     


Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile Lys Glu Leu Lys 
            980                 985                 990         


Ala Gly Tyr Ile Ser Gln Val Val  His Lys Ile Cys Glu  Leu Val Glu 
        995                 1000                 1005             


Lys Tyr  Asp Ala Val Ile Ala  Leu Glu Asp Leu Asn  Ser Gly Phe 
    1010                 1015                 1020             


Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe 
    1025                 1030                 1035             


Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys 
    1040                 1045                 1050             


Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile 
    1055                 1060                 1065             


Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly 
    1070                 1075                 1080             


Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro 
    1085                 1090                 1095             


Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile 
    1100                 1105                 1110             


Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr 
    1115                 1120                 1125             


Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn 
    1130                 1135                 1140             


Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr 
    1145                 1150                 1155             


Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn 
    1160                 1165                 1170             


Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys 
    1175                 1180                 1185             


Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile 
    1190                 1195                 1200             


Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser 
    1205                 1210                 1215             


Phe Met  Ala Leu Met Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile 
    1220                 1225                 1230             


Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile Ser Pro  Val Lys Asn 
    1235                 1240                 1245             


Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu 
    1250                 1255                 1260             


Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1265                 1270                 1275             


Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala 
    1280                 1285                 1290             


Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys 
    1295                 1300                 1305             


Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val Lys His  
    1310                 1315                 1320 


<210>  188
<211>  545
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::SH3lig fusion

<400>  188

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ser Gly 
    370                 375                 380                 


Ser Lys Lys Arg Arg Ile Lys Gln Asp Pro Pro Pro Ala Leu Pro Pro 
385                 390                 395                 400 


Lys Arg Arg Arg Ser Gly Gly Ser Ser Gly Gly Ser Pro Pro Pro Ala 
                405                 410                 415     


Leu Pro Pro Lys Arg Arg Arg Ser Gly Gly Ser Ser Gly Gly Ser Pro 
            420                 425                 430         


Pro Pro Ala Leu Pro Pro Lys Arg Arg Arg Ser Gly Gly Ser Ser Gly 
        435                 440                 445             


Gly Ser Pro Pro Pro Ala Leu Pro Pro Lys Arg Arg Arg Ser Gly Ser 
    450                 455                 460                 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly 
465                 470                 475                 480 


Thr Ser Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala 
                485                 490                 495     


Thr Asp Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val 
            500                 505                 510         


Leu Ser Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg 
        515                 520                 525             


Lys Arg Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg 
    530                 535                 540                 


Arg 
545 


<210>  189
<211>  1309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic SH3dom::Cas12a fusion

<400>  189

Met Ala Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn Gly Asn Asp 
1               5                   10                  15      


Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg Ile Arg Asp 
            20                  25                  30          


Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu Gly Lys Arg 
        35                  40                  45              


Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Gly Ser Ser Glu Thr 
    50                  55                  60                  


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Gly Gly Ser Gly Gly Ser 
65                  70                  75                  80  


Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
                85                  90                  95      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            100                 105                 110         


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        115                 120                 125             


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    130                 135                 140                 


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
145                 150                 155                 160 


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                165                 170                 175     


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            180                 185                 190         


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        195                 200                 205             


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    210                 215                 220                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
225                 230                 235                 240 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                245                 250                 255     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            260                 265                 270         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        275                 280                 285             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    290                 295                 300                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
305                 310                 315                 320 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                325                 330                 335     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
            340                 345                 350         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        355                 360                 365             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    370                 375                 380                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
385                 390                 395                 400 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                405                 410                 415     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            420                 425                 430         


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        435                 440                 445             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    450                 455                 460                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
465                 470                 475                 480 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                485                 490                 495     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            500                 505                 510         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        515                 520                 525             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    530                 535                 540                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
545                 550                 555                 560 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                565                 570                 575     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            580                 585                 590         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        595                 600                 605             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    610                 615                 620                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
625                 630                 635                 640 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                645                 650                 655     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            660                 665                 670         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        675                 680                 685             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    690                 695                 700                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
705                 710                 715                 720 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                725                 730                 735     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            740                 745                 750         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        755                 760                 765             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    770                 775                 780                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
785                 790                 795                 800 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                805                 810                 815     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            820                 825                 830         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        835                 840                 845             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    850                 855                 860                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
865                 870                 875                 880 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                885                 890                 895     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            900                 905                 910         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        915                 920                 925             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    930                 935                 940                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
945                 950                 955                 960 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                965                 970                 975     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            980                 985                 990         


Cys Glu Leu Val Glu Lys Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu 
        995                 1000                 1005             


Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met 
    1025                 1030                 1035             


Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys 
    1040                 1045                 1050             


Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser 
    1055                 1060                 1065             


Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
    1070                 1075                 1080             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1085                 1090                 1095             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1100                 1105                 1110             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1130                 1135                 1140             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1145                 1150                 1155             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1160                 1165                 1170             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1175                 1180                 1185             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1190                 1195                 1200             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1205                 1210                 1215             


Arg Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1220                 1225                 1230             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1235                 1240                 1245             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1250                 1255                 1260             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1265                 1270                 1275             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1280                 1285                 1290             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1295                 1300                 1305             


His 
    


<210>  190
<211>  582
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::SH3dom::VirF fusion

<400>  190

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser 
    370                 375                 380                 


Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp 
385                 390                 395                 400 


Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser 
                405                 410                 415     


Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg 
            420                 425                 430         


Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg Ser 
        435                 440                 445             


Gly Gly Ser Ser Gly Gly Ser Met Ser Gly Ser Lys Lys Arg Arg Ile 
    450                 455                 460                 


Lys Gln Asp Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn Gly Asn 
465                 470                 475                 480 


Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg Ile Arg 
                485                 490                 495     


Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu Gly Lys 
            500                 505                 510         


Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Ser Gly Gly Ser 
        515                 520                 525             


Ser Gly Gly Ser Ser Ala Ser Leu Ala Arg Gly Gly Pro Asn Ala Val 
    530                 535                 540                 


Gly Leu Leu Thr Thr Asn Glu Ser Phe Glu Lys Asn Ile Asn Glu Val 
545                 550                 555                 560 


Tyr Asn Arg Thr Arg Ala Glu Leu Asp Ala Ser Ser Arg Asp Arg Ser 
                565                 570                 575     


Arg Ser Gly Leu Ser Arg 
            580         


<210>  191
<211>  593
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::4xSH3lig::VirF fusion

<400>  191

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser 
    370                 375                 380                 


Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp 
385                 390                 395                 400 


Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser 
                405                 410                 415     


Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg 
            420                 425                 430         


Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg Ser 
        435                 440                 445             


Gly Gly Ser Ser Gly Gly Ser Met Ser Gly Ser Lys Lys Arg Arg Ile 
    450                 455                 460                 


Lys Gln Asp Pro Pro Pro Ala Leu Pro Pro Lys Arg Arg Arg Ser Gly 
465                 470                 475                 480 


Gly Ser Ser Gly Gly Ser Pro Pro Pro Ala Leu Pro Pro Lys Arg Arg 
                485                 490                 495     


Arg Ser Gly Gly Ser Ser Gly Gly Ser Pro Pro Pro Ala Leu Pro Pro 
            500                 505                 510         


Lys Arg Arg Arg Ser Gly Gly Ser Ser Gly Gly Ser Pro Pro Pro Ala 
        515                 520                 525             


Leu Pro Pro Lys Arg Arg Arg Ser Gly Gly Ser Ser Gly Gly Ser Ser 
    530                 535                 540                 


Ala Ser Leu Ala Arg Gly Gly Pro Asn Ala Val Gly Leu Leu Thr Thr 
545                 550                 555                 560 


Asn Glu Ser Phe Glu Lys Asn Ile Asn Glu Val Tyr Asn Arg Thr Arg 
                565                 570                 575     


Ala Glu Leu Asp Ala Ser Ser Arg Asp Arg Ser Arg Ser Gly Leu Ser 
            580                 585                 590         


Arg 
    


<210>  192
<211>  522
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic C-intein::VirD2 fusion

<400>  192

Met Ser Asn Ser Thr Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys 
1               5                   10                  15      


Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu 
            20                  25                  30          


Lys Asn Gly Phe Ile Ala Ser Asn Cys Phe Asn Ser Gly Gly Ser Ser 
        35                  40                  45              


Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 
    50                  55                  60                  


Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Pro Asp Arg Ala 
65                  70                  75                  80  


Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly Thr Lys Thr Leu Gln 
                85                  90                  95      


Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg Lys Gly Arg Leu Glu 
            100                 105                 110         


Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro Leu Pro Pro Asp Gln 
        115                 120                 125             


Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu Thr Gly Thr Tyr Asp 
    130                 135                 140                 


Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu Leu Thr Thr His Ile 
145                 150                 155                 160 


Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val Ala Ala Tyr Ala Ala 
                165                 170                 175     


Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser Gly Ala Gly Gly Gly 
            180                 185                 190         


Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp Arg Asp His Pro His 
        195                 200                 205             


Leu His Val Val Val Asn Arg Arg Glu Leu Leu Gly His Gly Trp Leu 
    210                 215                 220                 


Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr Asp Ala Leu Arg Ile 
225                 230                 235                 240 


Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile Ala Leu Asp Ala Ser 
                245                 250                 255     


Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro Ile Thr Tyr Ala Gln 
            260                 265                 270         


Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln Ile Arg Phe Glu Asp 
        275                 280                 285             


Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp His Pro Glu Phe Ser 
    290                 295                 300                 


Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser Ala Gly Gly Pro Glu 
305                 310                 315                 320 


Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu Ser Gln Val His Leu 
                325                 330                 335     


Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly Val Leu Val Arg Val 
            340                 345                 350         


Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe Val Ser Glu Thr Ile 
        355                 360                 365             


Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg Val Ala Glu Gly Arg 
    370                 375                 380                 


Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro Arg Ala Ala Thr Glu 
385                 390                 395                 400 


Ala Ala Thr His Thr Thr His Asp Arg Gln Arg Arg Ala Lys Arg Pro 
                405                 410                 415     


His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys Arg Val Thr Leu Glu 
            420                 425                 430         


Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly Glu Gln Asp Gly Ser 
        435                 440                 445             


Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser Arg Pro Ser Pro Pro 
    450                 455                 460                 


Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp Ser Leu Ser Ala Thr 
465                 470                 475                 480 


Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser Lys Arg Pro Arg Glu 
                485                 490                 495     


Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg Glu Arg Asp Glu Arg 
            500                 505                 510         


Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg 
        515                 520         


<210>  193
<211>  1354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Cas12a::N-intein fusion

<400>  193

Met Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Gly  Ser Ser Glu 
    1220                 1225                 1230             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Gly  Gly Ser Gly 
    1235                 1240                 1245             


Gly Ser  Gly Ser Cys Leu Ser  Tyr Glu Thr Glu Ile  Leu Thr Val 
    1250                 1255                 1260             


Glu Tyr  Gly Leu Leu Pro Ile  Gly Lys Ile Val Glu  Lys Arg Ile 
    1265                 1270                 1275             


Glu Cys  Thr Val Tyr Ser Val  Asp Asn Asn Gly Asn  Ile Tyr Thr 
    1280                 1285                 1290             


Gln Pro  Val Ala Gln Trp His  Asp Arg Gly Glu Gln  Glu Val Phe 
    1295                 1300                 1305             


Glu Tyr  Cys Leu Glu Asp Gly  Ser Leu Ile Arg Ala  Thr Lys Asp 
    1310                 1315                 1320             


His Lys  Phe Met Thr Val Asp  Gly Gln Met Leu Pro  Ile Asp Glu 
    1325                 1330                 1335             


Ile Phe  Glu Arg Glu Leu Asp  Leu Met Arg Val Asp  Asn Leu Pro 
    1340                 1345                 1350             


Asn 
    


<210>  194
<211>  629
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::N-intein::VirF fusion

<400>  194

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Pro Leu Val Arg Gln Ala Gly Thr Ser 
    370                 375                 380                 


Arg Pro Ser Pro Pro Thr Ala Thr Thr Arg Ala Ser Thr Ala Thr Asp 
385                 390                 395                 400 


Ser Leu Ser Ala Thr Ala His Leu Gln Gln Arg Arg Gly Val Leu Ser 
                405                 410                 415     


Lys Arg Pro Arg Glu Asp Asp Asp Gly Glu Pro Ser Glu Arg Lys Arg 
            420                 425                 430         


Glu Arg Asp Glu Arg Ser Lys Asp Gly Arg Gly Gly Asn Arg Arg Ser 
        435                 440                 445             


Gly Gly Ser Ser Gly Gly Ser Met Ser Gly Ser Lys Lys Arg Arg Ile 
    450                 455                 460                 


Lys Gln Asp Gly Ser Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val 
465                 470                 475                 480 


Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu 
                485                 490                 495     


Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro 
            500                 505                 510         


Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys 
        515                 520                 525             


Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met 
    530                 535                 540                 


Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu 
545                 550                 555                 560 


Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn Ser Gly Gly Ser Ser 
                565                 570                 575     


Gly Gly Ser Ser Ala Ser Leu Ala Arg Gly Gly Pro Asn Ala Val Gly 
            580                 585                 590         


Leu Leu Thr Thr Asn Glu Ser Phe Glu Lys Asn Ile Asn Glu Val Tyr 
        595                 600                 605             


Asn Arg Thr Arg Ala Glu Leu Asp Ala Ser Ser Arg Asp Arg Ser Arg 
    610                 615                 620                 


Ser Gly Leu Ser Arg 
625                 


<210>  195
<211>  1293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic C-intein::Cas12a fusion

<400>  195

Met Ala Asn Ser Thr Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys 
1               5                   10                  15      


Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu 
            20                  25                  30          


Lys Asn Gly Phe Ile Ala Ser Asn Cys Phe Asn Gly Ser Ser Glu Thr 
        35                  40                  45              


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Gly Gly Ser Gly Gly Ser 
    50                  55                  60                  


Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
65                  70                  75                  80  


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
                85                  90                  95      


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
            100                 105                 110         


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
        115                 120                 125             


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
    130                 135                 140                 


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
145                 150                 155                 160 


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
                165                 170                 175     


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
            180                 185                 190         


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
        195                 200                 205             


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
    210                 215                 220                 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
225                 230                 235                 240 


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
                245                 250                 255     


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
            260                 265                 270         


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
        275                 280                 285             


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
    290                 295                 300                 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
305                 310                 315                 320 


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
                325                 330                 335     


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
            340                 345                 350         


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
        355                 360                 365             


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
    370                 375                 380                 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
385                 390                 395                 400 


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
                405                 410                 415     


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
            420                 425                 430         


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
        435                 440                 445             


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
    450                 455                 460                 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
465                 470                 475                 480 


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
                485                 490                 495     


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
            500                 505                 510         


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
        515                 520                 525             


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
    530                 535                 540                 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
545                 550                 555                 560 


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
                565                 570                 575     


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
            580                 585                 590         


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
        595                 600                 605             


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
    610                 615                 620                 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
625                 630                 635                 640 


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
                645                 650                 655     


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
            660                 665                 670         


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
        675                 680                 685             


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
    690                 695                 700                 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
705                 710                 715                 720 


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
                725                 730                 735     


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
            740                 745                 750         


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
        755                 760                 765             


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
    770                 775                 780                 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
785                 790                 795                 800 


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
                805                 810                 815     


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
            820                 825                 830         


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
        835                 840                 845             


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
    850                 855                 860                 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
865                 870                 875                 880 


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
                885                 890                 895     


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
            900                 905                 910         


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
        915                 920                 925             


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
    930                 935                 940                 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
945                 950                 955                 960 


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
                965                 970                 975     


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
            980                 985                 990         


Asn Ser Gly Phe Lys Asn Ser Arg  Val Lys Val Glu Lys  Gln Val Tyr 
        995                 1000                 1005             


Gln Lys  Phe Glu Lys Met Leu  Ile Asp Lys Leu Asn  Tyr Met Val 
    1010                 1015                 1020             


Asp Lys  Lys Ser Asn Pro Cys  Ala Thr Gly Gly Ala  Leu Lys Gly 
    1025                 1030                 1035             


Tyr Gln  Ile Thr Asn Lys Phe  Glu Ser Phe Lys Ser  Met Ser Thr 
    1040                 1045                 1050             


Gln Asn  Gly Phe Ile Phe Tyr  Ile Pro Ala Trp Leu  Thr Ser Lys 
    1055                 1060                 1065             


Ile Asp  Pro Ser Thr Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr 
    1070                 1075                 1080             


Thr Ser  Ile Ala Asp Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg 
    1085                 1090                 1095             


Ile Met  Tyr Val Pro Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp 
    1100                 1105                 1110             


Tyr Lys  Asn Phe Ser Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp 
    1115                 1120                 1125             


Lys Leu  Tyr Ser Tyr Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro 
    1130                 1135                 1140             


Lys Lys  Asn Asn Val Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser 
    1145                 1150                 1155             


Ala Tyr  Lys Glu Leu Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln 
    1160                 1165                 1170             


Gly Asp  Ile Arg Ala Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe 
    1175                 1180                 1185             


Tyr Ser  Ser Phe Met Ala Leu  Met Ser Leu Met Leu  Gln Met Arg 
    1190                 1195                 1200             


Asn Ser  Ile Thr Gly Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro 
    1205                 1210                 1215             


Val Lys  Asn Ser Asp Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu 
    1220                 1225                 1230             


Ala Gln  Glu Asn Ala Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly 
    1235                 1240                 1245             


Ala Tyr  Asn Ile Ala Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe 
    1250                 1255                 1260             


Lys Lys  Ala Glu Asp Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile 
    1265                 1270                 1275             


Ser Asn  Lys Glu Trp Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1280                 1285                 1290             


<210>  196
<211>  1229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Cas12a-no NLS sequence

<400>  196

Met Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His 
    1220                 1225                 


<210>  197
<211>  1714
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic VirD2::Cas12a fusion

<400>  197

Met Pro Asp Arg Ala Gln Val Ile Ile Arg Ile Val Pro Gly Gly Gly 
1               5                   10                  15      


Thr Lys Thr Leu Gln Gln Ile Ile Asn Gln Leu Glu Tyr Leu Ser Arg 
            20                  25                  30          


Lys Gly Arg Leu Glu Leu Gln Arg Ser Ala Arg His Leu Asp Ile Pro 
        35                  40                  45              


Leu Pro Pro Asp Gln Ile His Glu Leu Ala Arg Ser Trp Val Gln Glu 
    50                  55                  60                  


Thr Gly Thr Tyr Asp Glu Ser Gln Pro Asp Glu Glu Arg Gln Gln Glu 
65                  70                  75                  80  


Leu Thr Thr His Ile Ile Val Ser Phe Pro Ala Gly Thr Ser Gln Val 
                85                  90                  95      


Ala Ala Tyr Ala Ala Ser Arg Glu Trp Ala Ala Glu Met Phe Gly Ser 
            100                 105                 110         


Gly Ala Gly Gly Gly Arg Tyr Asn Tyr Leu Thr Ala Phe His Ile Asp 
        115                 120                 125             


Arg Asp His Pro His Leu His Val Val Val Asn Arg Arg Glu Leu Leu 
    130                 135                 140                 


Gly His Gly Trp Leu Lys Ile Ser Arg Arg His Pro Gln Leu Asn Tyr 
145                 150                 155                 160 


Asp Ala Leu Arg Ile Lys Met Ala Glu Ile Ser Leu Arg His Gly Ile 
                165                 170                 175     


Ala Leu Asp Ala Ser Arg Arg Ala Glu Arg Gly Ile Thr Glu Arg Pro 
            180                 185                 190         


Ile Thr Tyr Ala Gln Tyr Arg Arg Leu Glu Arg Glu Gln Ala Arg Gln 
        195                 200                 205             


Ile Arg Phe Glu Asp Ala Asp Leu Glu Gln Ser Ser Pro Gln Gly Asp 
    210                 215                 220                 


His Pro Glu Phe Ser Gln Pro Phe Asp Thr Ser Pro Phe Glu Ala Ser 
225                 230                 235                 240 


Ala Gly Gly Pro Glu Asp Met Pro Arg Pro Asn Asn Arg Gln Asn Glu 
                245                 250                 255     


Ser Gln Val His Leu Gln Glu Pro Ala Gly Val Ser Asn Glu Ala Gly 
            260                 265                 270         


Val Leu Val Arg Val Ala Leu Glu Thr Glu Arg Leu Ala Gln Pro Phe 
        275                 280                 285             


Val Ser Glu Thr Ile Leu Ala Asp Asp Ile Gly Ser Gly Ser Ser Arg 
    290                 295                 300                 


Val Ala Glu Gly Arg Val Glu Ser Ala Asn Arg Thr Pro Asp Ile Pro 
305                 310                 315                 320 


Arg Ala Ala Thr Glu Ala Ala Thr His Thr Thr His Asp Arg Gln Arg 
                325                 330                 335     


Arg Ala Lys Arg Pro His Asp Asp Asp Gly Gly Pro Ser Gly Ala Lys 
            340                 345                 350         


Arg Val Thr Leu Glu Gly Ile Ala Val Gly Pro Gln Ala Asn Ala Gly 
        355                 360                 365             


Glu Gln Asp Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ser Gly 
    370                 375                 380                 


Ser Lys Lys Arg Arg Ile Lys Gln Asp Ser Lys Leu Glu Lys Phe Thr 
385                 390                 395                 400 


Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val 
                405                 410                 415     


Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp 
            420                 425                 430         


Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg 
        435                 440                 445             


Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys 
    450                 455                 460                 


Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu 
465                 470                 475                 480 


Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu 
                485                 490                 495     


Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys 
            500                 505                 510         


Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp 
        515                 520                 525             


Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr 
    530                 535                 540                 


Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser 
545                 550                 555                 560 


Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile 
                565                 570                 575     


Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His 
            580                 585                 590         


Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val 
        595                 600                 605             


Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu 
    610                 615                 620                 


Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser 
625                 630                 635                 640 


Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln 
                645                 650                 655     


Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val 
            660                 665                 670         


Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser 
        675                 680                 685             


Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser 
    690                 695                 700                 


Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe 
705                 710                 715                 720 


Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile 
                725                 730                 735     


Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp 
            740                 745                 750         


Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val 
        755                 760                 765             


Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile 
    770                 775                 780                 


Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu 
785                 790                 795                 800 


Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu 
                805                 810                 815     


Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe 
            820                 825                 830         


Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met 
        835                 840                 845             


Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala 
    850                 855                 860                 


Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly 
865                 870                 875                 880 


Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr 
                885                 890                 895     


Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys 
            900                 905                 910         


Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys 
        915                 920                 925             


Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys 
    930                 935                 940                 


Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys 
945                 950                 955                 960 


Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys 
                965                 970                 975     


Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys 
            980                 985                 990         


Lys Trp Met Ala Tyr Tyr Asn Pro  Ser Glu Asp Ile Gln  Lys Ile Tyr 
        995                 1000                 1005             


Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met Phe Asn  Leu Asn Asp 
    1010                 1015                 1020             


Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp Ser Ile  Ser Arg Tyr 
    1025                 1030                 1035             


Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn Phe Ser  Glu Thr Glu 
    1040                 1045                 1050             


Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg Glu Val  Glu Glu Gln 
    1055                 1060                 1065             


Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser Lys Lys  Glu Val Asp 
    1070                 1075                 1080             


Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met Phe Gln  Ile Tyr Asn 
    1085                 1090                 1095             


Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr Pro Asn  Leu His Thr 
    1100                 1105                 1110             


Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn Asn His  Gly Gln Ile 
    1115                 1120                 1125             


Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu 
    1130                 1135                 1140             


Lys Lys  Glu Glu Leu Val Val  His Pro Ala Asn Ser  Pro Ile Ala 
    1145                 1150                 1155             


Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr 
    1160                 1165                 1170             


Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu 
    1175                 1180                 1185             


His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys 
    1190                 1195                 1200             


Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys His Asp  Asp Asn Pro 
    1205                 1210                 1215             


Tyr Val  Ile Gly Ile Asp Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile 
    1220                 1225                 1230             


Val Val  Val Asp Gly Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu 
    1235                 1240                 1245             


Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp 
    1250                 1255                 1260             


Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala 
    1265                 1270                 1275             


Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala 
    1280                 1285                 1290             


Gly Tyr  Ile Ser Gln Val Val  His Lys Ile Cys Glu  Leu Val Glu 
    1295                 1300                 1305             


Lys Tyr  Asp Ala Val Ile Ala  Leu Glu Asp Leu Asn  Ser Gly Phe 
    1310                 1315                 1320             


Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe 
    1325                 1330                 1335             


Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys 
    1340                 1345                 1350             


Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile 
    1355                 1360                 1365             


Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly 
    1370                 1375                 1380             


Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro 
    1385                 1390                 1395             


Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile 
    1400                 1405                 1410             


Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr 
    1415                 1420                 1425             


Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn 
    1430                 1435                 1440             


Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr 
    1445                 1450                 1455             


Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn 
    1460                 1465                 1470             


Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys 
    1475                 1480                 1485             


Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile 
    1490                 1495                 1500             


Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser 
    1505                 1510                 1515             


Phe Met  Ala Leu Met Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile 
    1520                 1525                 1530             


Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile Ser Pro  Val Lys Asn 
    1535                 1540                 1545             


Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu 
    1550                 1555                 1560             


Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1565                 1570                 1575             


Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala 
    1580                 1585                 1590             


Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys 
    1595                 1600                 1605             


Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val Lys His  Gly Ser Lys 
    1610                 1615                 1620             


Lys Arg  Arg Ile Lys Gln Asp  Ser Gly Ser Gly Gly  Ser Ser Gly 
    1625                 1630                 1635             


Gly Ser  Ser Gly Pro Leu Val  Arg Gln Ala Gly Thr  Ser Arg Pro 
    1640                 1645                 1650             


Ser Pro  Pro Thr Ala Thr Thr  Arg Ala Ser Thr Ala  Thr Asp Ser 
    1655                 1660                 1665             


Leu Ser  Ala Thr Ala His Leu  Gln Gln Arg Arg Gly  Val Leu Ser 
    1670                 1675                 1680             


Lys Arg  Pro Arg Glu Asp Asp  Asp Gly Glu Pro Ser  Glu Arg Lys 
    1685                 1690                 1695             


Arg Glu  Arg Asp Glu Arg Ser  Lys Asp Gly Arg Gly  Gly Asn Arg 
    1700                 1705                 1710             


Arg 
    


<210>  198
<211>  1100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic a2 rt-pr

<400>  198
cttatttgtt gattctgtgg ccatagatta ggattttttt tcacgaaatt gcttcttgaa       60

attacgtgat ggattttgat tctgatttat cttgtgattg ttgactctac agatgcagat      120

cttcgtcaag accctcaccg gaaagaccat cacccttgag gtggaaagct ctgacaccat      180

cgacaacgtc aaggccaaga tccaggacaa ggaaggaatt cccccggatc agcaacgtct      240

catcttcgcc ggaaagcagc tcgaggacgg ccgtaccctc gccgactaca acatccagaa      300

ggagtcaacc cttcaccttg tccttcgtct ccgtggtggc atgcagatct tcgtcaagac      360

tctcactggc aaaaccataa ccctagaggt cgaaagctct gacaccattg acaacgtcaa      420

ggccaagatc caggacaagg agggaatccc cccagaccag caacgtctca tcttcgccgg      480

aaagcaactt gaggacgggc gcaccctcgc cgactacaac atccagaagg aatcaaccct      540

tcacctcgtc ctccgtctcc gtggtggcat gcagatcttc gttaagaccc tcaccggcaa      600

gactataacc ctagaagtcg agagctccga caccatcgac aacgtcaagg ctaagatcca      660

ggacaaggag ggtatccccc cagaccagca gaggctgatc ttcgccggca agcagctcga      720

ggacggacgt acccttgctg actacaacat ccagaaggag tcaactctcc acttggtgtt      780

gcgtcttcgt ggtggtatgc agatcttcgt caagaccctt acgggtaaga ctattaccct      840

cgaggtggag agctccgaca ccattgacaa tgtgaaggcg aagatccagg acaaggaagg      900

aatcccaccg gaccagcaga ggcttatttt tgctggcaaa cagctagagg atggaaggac      960

cctcgctgac tacaacatcc agaaggagtc aactctgcac ttggtgttgc gtcttcgtgg     1020

ggggttttca aatgctgctg atgaagtggc aactcaatta ctgaattttg acctcttgaa     1080

gcttgccggt gatgttgagt                                                 1100


<210>  199
<211>  1139
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic D3 RT-PCR

<400>  199
cttatttgtt gattctgtgg ccatagatta ggattttttt tcacgaaatt gcttcttgaa       60

attacgtgat ggattttgat tctgatttat cttgtgattg ttgactctac agatgcagat      120

cttcgtcaag accctcaccg gaaagaccat cacccttgag gtggaaagct ctgacaccat      180

cgacaacgtc aaggccaaga tccaggacaa ggaaggaatt cccccggatc agcaacgtct      240

catcttcgcc ggaaagcagc tcgaggacgg ccgtaccctc gccgactaca acatccagaa      300

ggagtcaacc cttcaccttg tccttcgtct ccgtggtggc atgcagatct tcgtcaagac      360

tctcactggc aaaaccataa ccctagaggt cgaaagctct gacaccattg acaacgtcaa      420

ggccaagatc caggacaagg agggaatccc cccagaccag caacgtctca tcttcgccgg      480

aaagcaactt gaggacgggc gcaccctcgc cgactacaac atccagaagg aatcaaccct      540

tcacctcgtc ctccgtctcc gtggtggcat gcagatcttc gttaagaccc tcaccggcaa      600

gactataacc ctagaagtcg agagctccga caccatcgac aacgtcaagg ctaagatcca      660

ggacaaggag ggtatccccc cagaccagca gaggctgatc ttcgccggca agcagctcga      720

ggacggacgt acccttgctg actacaacat ccagaaggag tcaactctcc acttggtgtt      780

gcgtcttcgt ggtggtatgc agatcttcgt caagaccctt acgggtaaga ctattaccct      840

cgaggtggag agctccgaca ccattgacaa tgtgaaggcg aagatccagg acaaggaagg      900

aatcccaccg gaccagcaga ggcttatttt tgctggcaaa cagctagagg atggaaggac      960

cctcgctgac tacaacatcc agaaggagtc aactctgcac ttggtgttgc gtcttcgtgg     1020

ggggttttca aatgctgctg atgaagtggc aactcaatta ctgaattttg acctcttgaa     1080

gcttgccggt gatgttgagt ctaaccctgg accaatggcg caagttagca gaatctgca      1139


<210>  200
<211>  1131
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic F3 RT-PCR


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (633)..(633)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (636)..(636)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (830)..(830)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (982)..(983)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1018)..(1018)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1066)..(1067)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1082)..(1082)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1105)..(1106)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1115)..(1116)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1123)..(1123)
<223>  n is a, c, g, or t

<400>  200
cgtangttgt tnnttctgtg gccatagatt aggatttttt ttcncgaaat tgcttcttga       60

aattacgtga tggattttga ttctgattta tcttgtgatt gttgactcta cagatgcaga      120

tcttcgtcaa gaccctcacc ggaaagacca tcacccttga ggtggaaagc tctgacacca      180

tcgacaacgt caaggccaag atccaggaca aggaaggaat tcccccggat cagcaacgtc      240

tcatcttcgc cggaaagcag ctcgaggacg gccgtaccct cgccgactac aacatccaga      300

aggagtcaac ccttcacctt gtccttcgtc tccgtggtgg catgcagatc ttcgtcaaga      360

ctctcactgg caaaaccata accctagagg tcgaaagctc tgacaccatt gacaacgtca      420

aggccaagat ccaggacaag gagggaatcc ccccagacca gcaacgtctc atcttcgccg      480

gaaagcaact tgaggacggg cgcaccctcg ccgactacaa catccagaag gaatcaaccc      540

ttcacctcgt cctccgtctc cgtggtggca tgcagatctt cgttaagacc ctcaccggca      600

agactataac cctagaagtc gagagctccg acnccntcga caacgtcaag gctaagatcc      660

aggacaagga gggtatcccc ccagaccagc agaggctgat cttcgccggc aagcagctcg      720

aggacggacg tacccttgct gactacaaca tccagaagga gtcaactctc cacttggtgt      780

tgcgtcttcg tggtggtatg cagatcttcg tcaagaccct tacgggtaan actattaccc      840

tcgaggtgga gagctccgac accattgaca atgtgaaggc gaagatccag gacaaggaag      900

gaatcccacc ggaccggcag aggcttattt ttgctggcaa acagctagag gatggaagga      960

ccctcgctga ctacaacatc cnnaaggagt caactctgca cttggtgttg cgtcttcntg     1020

gggggttttc aaatgctgct gatgaagtgg caactcaatt actgannttt gacctcttga     1080

ancttgccgg tgatgttgag tctanncctg gaccnntggc gcnagttagc a              1131


<210>  201
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic PM10281

<400>  201
cttggacaag aagaagatcg cttggcctc                                         29


<210>  202
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic PM10282

<400>  202
cgccaacaca acaatttaac tctgggagga ac                                     32


<210>  203
<211>  1107
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic A2 Left flank


<220>
<221>  misc_feature
<222>  (655)..(655)
<223>  n is a, c, g, or t

<400>  203
cttatttgtt gattctgtgg ccatagatta ggattttttt tcacgaaatt gcttcttgaa       60

attacgtgat ggattttgat tctgatttat cttgtgattg ttgactctac agatgcagat      120

cttcgtcaag accctcaccg gaaagaccat cacccttgag gtggaaagct ctgacaccat      180

cgacaacgtc aaggccaaga tccaggacaa ggaaggaatt cccccggatc agcaacgtct      240

catcttcgcc ggaaagcagc tcgaggacgg ccgtaccctc gccgactaca acatccagaa      300

ggagtcaacc cttcaccttg tccttcgtct ccgtggtggc atgcagatct tcgtcaagac      360

tctcactggc aaaaccataa ccctagaggt cgaaagctct gacaccattg acaacgtcaa      420

ggccaaagat ccaggacaag gagggaatcc ccccagacca gcaacgtctc atcttcgccg      480

gaaagcaact tgaggacggg cgcaccctcg ccgactacaa catccagaag gaatcaaccc      540

ttcacctcgt cctccgtctc cgtggtggca tgcagatctt cgttaagacc ctcaccggca      600

agactataac cctagaagtc gagagctccg acaccatcga caacgtcaag gctangatcc      660

aggacaagga gggtatcccc ccagaccagc agaggctgat cttcgccggc aagcagctcg      720

aggacggacg tacccttgct gactacaaca tccagaagga gtcaactctc cacttggtgt      780

tgcgtcttcg tggtggtatg cagatcttcg tcaagaccct tacgggtaag actattaccc      840

tcgaggtgga gagctccgac accattgaca atgtgaaggc gaagatccag gacaaggaag      900

gaatcccacc ggaccagcag aggcttattt ttgctggcaa acagctagag gatggaagga      960

ccctcgctga ctacaacatc cagaaggagt caactctgca cttggtgttg cgtcttcgtg     1020

gggggttttc aaatgctgct gatgaagtgg caactcaatt actgaatttt gacctcttga     1080

agcttgccgg tgatgttgag tctaacc                                         1107


<210>  204
<211>  1253
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic A2 Right flank


<220>
<221>  misc_feature
<222>  (965)..(965)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (980)..(980)
<223>  n is a, c, g, or t

<400>  204
ctacgtgaaa ggcgagatca ccaaggtagt cggcaaataa gctggagctg atgtctgtgt       60

gatgtctgat gttggatttt cccagacatt ttaagaagaa atgtgatgtg taatgggtct      120

gtaatgacct ttgaaaataa gtttggtttg tgttgaactc tattgtccca ttaatgttac      180

tactgtttgt tatcaatttg tggagctgat atataattat caactgtatg ctggcatatt      240

gtgtttgaat tttgttctca atccagtgaa ttggcgtata ttagtgggtt ttttattctt      300

catgcttatc acggaggaaa agcagggatg agttgtgtga aggatggtga tcatcccacg      360

aattattaga ttttggtatt ataggttaaa gatatttatt aggtagggag aactcttgga      420

ttagattcta aagtgatatt ttgaaaacac accaaaggat ttttgaacaa acggagatca      480

tgatccctag tttcaattag ctgcccctta ccaagaggta gcaacttaaa aattatgctc      540

gtgaagcata tttggtatcg tatataaatt atgtaagcaa tctgcttcag ttggaacatt      600

aattggcttg cggaatgcac atttagatga tccacacagg tccacataaa aattcctaat      660

caattttagt tatgcaatct ttctgcttca ggtagtcctt gtcttacaga aagcacattg      720

agatgatccc cacacagatc cacataaaaa attcctaatc aataataact tgaaaatcat      780

taaaagatgt aatgccatac taatccctaa tttttgtgca agtttttgta tactggaccc      840

caaaaaatac caaaaagaaa aaacaagtta ttcagtgata tttttctgct ccaatataaa      900

tttgattacc aaataccaaa aaataaaaac actattcagt ggtatttttc tgctccaata      960

ctggncccca aattaatcan aatcggatcc gtttaacaga taaaaacaaa gcgatcgggt     1020

taaaatccca tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacca     1080

agtgatattt ttctgctccg atataaattt gattacaacg aaaaaaagtg gtctactcac     1140

atgtttctcc attttacttg tgtataaaac tcatttcaag ttgtatctga ttcgtcgaaa     1200

aaacaaaaca gaatagtaat actctatacc ctttttatca tcattaattt gta            1253


<210>  205
<211>  653
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic A7 Right flank


<220>
<221>  misc_feature
<222>  (646)..(646)
<223>  n is a, c, g, or t

<400>  205
aaataacaac gcaggtttat acatgaaaca aatgtcatta ccaagtgata tttttctgct       60

ccgatataaa tttgattaca acgaaaaaaa gtggtctact cacatgtttc tccattttac      120

ttgtgtataa aactcatttc aagttgtatc tgattcgtcg aaaaaacaaa acagaatagt      180

aatactctat acccttttta tcatcattaa tttgtatttt tgtatactgg accccaaaaa      240

ataccaaaaa gaaaaaacaa gttattcagt gatatttttc tgctccaata taaatttgat      300

taccaaatac caaaaaataa aaacactatt cagtggtatt tttctgctcc aatactggac      360

cccaaattaa tcagaatcgg atccgtttaa cagataaaaa caaaagcgat cgggttaaaa      420

tcccattttt acaaataaca acgcaggttt atacatgaaa caaatgtcat taccaagtga      480

tatttttctg ctccgatata aatttgatta caacgaaaaa aagtggtcta ctcacatgtt      540

tctccatttt acttgtgtat aaaactcatt tcaagttgta tctgattcgt cgaaaaaaca      600

aaacagaata gtaatactct ataccctttt tatcatcatt aatttngtaa tta             653


<210>  206
<211>  687
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic B2 Left flank


<220>
<221>  misc_feature
<222>  (430)..(430)
<223>  n is a, c, g, or t

<400>  206
tttttgtata ctggacccca aaaaatacca aaaagaaaaa acaagttatt cagtgatatt       60

tttctgctcc aatataaatt tgattaccaa ataccaaaaa ataaaaacac tattcagtgg      120

tatttttctg ctccaatact ggaccccaaa ttaatcagaa tcggatccgt ttaacagata      180

aaaacaaaag cgatcgggtt aaaatcccat ttttacaaat aacaacgcag gtttatacat      240

gaaacaaatg tcattaccaa gtgatatttt tctgctccga tataaatttg attacaacga      300

aaaaaagtgg tctactcaca tgtttctcca ttttacttgt gtataaaact catttcaagt      360

tgtatctgat tcgtcgaaaa aacaaaacag aatagtaata ctctataccc tttttatcat      420

cattaatttn gtaattagga caaggaagga atcccaccgg accagcagag gcttattttt      480

gctggcaaac agctagagga tggaaggacc ctcgctgact acaacatcca gaaggagtca      540

actctgcact tggtgttgcg tcttcgtggg gggttttcaa atgctgctga tgaagtggca      600

actcaattac tgaattttga cctcttgaag cttgccggtg atgttgagtc taaccctgga      660

ccaatggcgc aagttagcag aatctgc                                          687


<210>  207
<211>  1260
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic B2 Right flank


<220>
<221>  misc_feature
<222>  (1251)..(1251)
<223>  n is a, c, g, or t

<400>  207
tacgtgaaag gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg       60

atgtctgatg ttggattttc ccagacattt taagaagaaa tgtgatgtgt aatgggtctg      120

taatgacctt tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact      180

actgtttgtt atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg      240

tgtttgaatt ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc      300

atgcttatca cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga      360

attattagat tttggtatta taggttaaag atatttatta ggtagggaga actcttggat      420

tagattctaa agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat      480

gatccctagt ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg      540

tgaagcatat ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta      600

attggcttgc ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc      660

aattttagtt atgcaatctt tctgcttcag gtagtccttg tcttacagaa agcacattga      720

gatgatcccc acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt      780

aaaagatgta atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc      840

aaaaaatacc aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat      900

ttgattacca aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac      960

tggaccccaa attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt     1020

taaaatccca tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacca     1080

agtgatattt ttctgctccg atataaattt gattacaacg aaaaaaagtg gtctactcac     1140

atgtttctcc attttacttg tgtataaaac tcatttcaag ttgtatctga ttcgtcgaaa     1200

aaacaaaaca gaatagtaat actctatacc ctttttatca tcattaattt ngtaattata     1260


<210>  208
<211>  1255
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic B4 Right flank


<220>
<221>  misc_feature
<222>  (1251)..(1251)
<223>  n is a, c, g, or t

<400>  208
tacgtgaaag gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg       60

atgtctgatg ttggattttc ccagacattt taagaagaaa tgtgatgtgt aatgggtctg      120

taatgacctt tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact      180

actgtttgtt atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg      240

tgtttgaatt ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc      300

atgcttatca cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga      360

attattagat tttggtatta taggttaaag atatttatta ggtagggaga actcttggat      420

tagattctaa agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat      480

gatccctagt ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg      540

tgaagcatat ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta      600

attggcttgc ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc      660

aattttagtt atgcaatctt tctgcttcag gtagtccttg tcttacagaa agcacattga      720

gatgatcccc acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt      780

aaaagatgta atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc      840

aaaaaatacc aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat      900

ttgattacca aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac      960

tggaccccaa attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt     1020

taaaatccca tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacca     1080

agtgatattt ttctgctccg atataaattt gattacaacg aaaaaaagtg gtctactcac     1140

atgtttctcc attttacttg tgtataaaac tcatttcaag ttgtatctga ttcgtcgaaa     1200

aaacaaaaca gaatagtaat actctatacc ctttttatca tcattaattt ngtaa          1255


<210>  209
<211>  835
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic C2 Left flank

<400>  209
ttgattctgt ggccatagat taggattttt tttcacgaaa ttgcttcttg aaattacgtg       60

atggattttg attctgattt atcttgtgat tgttgactct acagatgcag atcttcgtca      120

agaccctcac cggaaagacc atcacccttg aggtggaaag ctctgacacc atcgacaacg      180

tcaaggccaa gatccaggac aaggaaggaa ttcccccgga tcagcaacgt ctcatcttcg      240

ccggaaagca gctcgaggac ggccgtaccc tcgccgacta caacatccag aaggagtcaa      300

cccttcacct tgtccttcgt ctccgtggtg gcatgcagat cttcgtcaag actctcactg      360

gcaaaaccat aaccctagag gtcgaaagct ctgacaccat tgacaacgtc aaggccaaga      420

tccaggacaa ggagggaatc cccccagacc agcaacgtct catcttcgcc ggaaagcaac      480

ttgaggacgg gcgcaccctc gccgactaca acatccagaa ggaatcaacc cttcacctcg      540

tcctccgtct ccgtggtggc atgcagatct tcgttaagac cctcaccggc aagactataa      600

ccctagaagt cgagagctcc gacaccatcg acaacgtcaa ggctaagatc caggacaagg      660

agggtatccc cccagaccag cagaggctga tcttcgccgg caagcagctc gaggacggac      720

gtacccttgc tgactacaac atccagaagg agtcaactct ccacttggtg ttgcgtcttc      780

gtggtggtat gcagatcttc gtcaagaccc ttacgggtaa gactattacc ctcga           835


<210>  210
<211>  1250
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic C2 Right flank


<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (694)..(694)
<223>  n is a, c, g, or t

<400>  210
tacgtgaaag gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg       60

atgtctgatg ttggattttc cnagacattt taagaagaaa tgtgatgtgt aatgggtctg      120

taatgacctt tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact      180

actgtttgtt atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg      240

tgtttgaatt ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc      300

atgcttatca cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga      360

attattagat tttggtatta taggttaaag atatttatta ggtagggaga actcttggat      420

tagattctaa agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat      480

gatccctagt ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg      540

tgaagcatat ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta      600

attggcttgc ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc      660

aattttagtt atgcaatctt tctgcttcag gtantccttg tcttacagaa agcacattga      720

gatgatcccc acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt      780

aaaagatgta atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc      840

aaaaaatacc aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat      900

ttgattacca aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac      960

tggaccccaa attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt     1020

taaaatccca tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacca     1080

agtgatattt ttctgctccg atataaattt gattacaacg aaaaaaagtg gtctactcac     1140

atgtttctcc attttacttg tgtataaaac tcatttcaag ttgtatctga ttcgtcgaaa     1200

aaacaaaaca gaatagtaat actctatacc ctttttatca tcattaattt                1250


<210>  211
<211>  1264
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic E6 Right flank


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  211
ttgganattt gtccntacgt gaaaggcgag atcaccaagg tagtcggcaa ataagctgga       60

gctgatgtct gtgtgatgtc tgatgttgga ttttcccaga cattttaaga agaaatgtga      120

tgtgtaatgg gtctgtaatg acctttgaaa ataagtttgg tttgtgttga actctattgt      180

cccattaatg ttactactgt ttgttatcaa tttgtggagc tgatatataa ttatcaactg      240

tatgctggca tattgtgttt gaattttgtt ctcaatccag tgaattggcg tatattagtg      300

ggttttttat tcttcatgct tatcacggag gaaaagcagg gatgagttgt gtgaaggatg      360

gtgatcatcc cacgaattat tagattttgg tattataggt taaagatatt tattaggtag      420

ggagaactct tggattagat tctaaagtga tattttgaaa acacaccaaa ggatttttga      480

acaaacggag atcatgatcc ctagtttcaa ttagctgccc cttaccaaga ggtagcaact      540

taaaaattat gctcgtgaag catatttggt atcgtatata aattatgtaa gcaatctgct      600

tcagttggaa cattaattgg cttgcggaat gcacatttag atgatccaca caggtccaca      660

taaaaattcc taatcaattt tagttatgca atctttctgc ttcaggtagt ccttgtctta      720

cagaaagcac attgagatga tccccacaca gatccacata aaaaattcct aatcaataat      780

aacttgaaaa tcattaaaag atgtaatgcc atactaatcc ctaatttttg tgcaagtttt      840

tgtatactgg accccaaaaa ataccaaaaa gaaaaaacaa gttattcagt gatatttttc      900

tgctccaata taaatttgat taccaaatac caaaaaataa aaacactatt cagtggtatt      960

tttctgctcc aatactggac cccaaattaa tcagaatcgg atccgtttaa cagataaaaa     1020

caaaagcgat cgggttaaaa tcccattttt acaaataaca acgcaggttt atacatgaaa     1080

caaatgtcat taccaagtga tatttttctg ctccgatata aatttgatta caacgaaaaa     1140

aagtggtcta ctcacatgtt tctccatttt acttgtgtat aaaactcatt tcaagttgta     1200

tctgattcgt cgaaaaaaca aaacagaata gtaatactct ataccctttt tatcatcatt     1260

aatt                                                                  1264


<210>  212
<211>  1254
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic G7 Right flank

<400>  212
tacgtgaaag gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg       60

atgtctgatg ttggattttc ccagacattt taagaagaaa tgtgatgtgt aatgggtctg      120

taatgacctt tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact      180

actgtttgtt atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg      240

tgtttgaatt ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc      300

atgcttatca cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga      360

attattagat tttggtatta taggttaaag atatttatta ggtagggaga actcttggat      420

tagattctaa agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat      480

gatccctagt ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg      540

tgaagcatat ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta      600

attggcttgc ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc      660

aattttagtt atgcaatctt tctgcttcag gtagtccttg tcttacagaa agcacattga      720

gatgatcccc acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt      780

aaaagatgta atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc      840

aaaaaatacc aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat      900

ttgattacca aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac      960

tggaccccaa attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt     1020

taaaatccca tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacca     1080

agtgatattt ttctgctccg atataaattt gattacaacg aaaaaaagtg gtctactcac     1140

atgtttctcc attttacttg tgtataaaac tcatttcaag ttgtatctga ttcgtcgaaa     1200

aaacaaaaca gaatagtaat actctatacc ctttttatca tcattaattt gtaa           1254


<210>  213
<211>  1255
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic G8 Right flank


<220>
<221>  misc_feature
<222>  (1251)..(1251)
<223>  n is a, c, g, or t

<400>  213
tacgtgaaag gcgagatcac caaggtagtc ggcaaataag ctggagctga tgtctgtgtg       60

atgtctgatg ttggattttc ccagacattt taagaagaaa tgtgatgtgt aatgggtctg      120

taatgacctt tgaaaataag tttggtttgt gttgaactct attgtcccat taatgttact      180

actgtttgtt atcaatttgt ggagctgata tataattatc aactgtatgc tggcatattg      240

tgtttgaatt ttgttctcaa tccagtgaat tggcgtatat tagtgggttt tttattcttc      300

atgcttatca cggaggaaaa gcagggatga gttgtgtgaa ggatggtgat catcccacga      360

attattagat tttggtatta taggttaaag atatttatta ggtagggaga actcttggat      420

tagattctaa agtgatattt tgaaaacaca ccaaaggatt tttgaacaaa cggagatcat      480

gatccctagt ttcaattagc tgccccttac caagaggtag caacttaaaa attatgctcg      540

tgaagcatat ttggtatcgt atataaatta tgtaagcaat ctgcttcagt tggaacatta      600

attggcttgc ggaatgcaca tttagatgat ccacacaggt ccacataaaa attcctaatc      660

aattttagtt atgcaatctt tctgcttcag gtagtccttg tcttacagaa agcacattga      720

gatgatcccc acacagatcc acataaaaaa ttcctaatca ataataactt gaaaatcatt      780

aaaagatgta atgccatact aatccctaat ttttgtgcaa gtttttgtat actggacccc      840

aaaaaatacc aaaaagaaaa aacaagttat tcagtgatat ttttctgctc caatataaat      900

ttgattacca aataccaaaa aataaaaaca ctattcagtg gtatttttct gctccaatac      960

tggaccccaa attaatcaga atcggatccg tttaacagat aaaaacaaaa gcgatcgggt     1020

taaaatccca tttttacaaa taacaacgca ggtttataca tgaaacaaat gtcattacca     1080

agtgatattt ttctgctccg atataaattt gattacaacg aaaaaaagtg gtctactcac     1140

atgtttctcc attttacttg tgtataaaac tcatttcaag ttgtatctga ttcgtcgaaa     1200

aaacaaaaca gaatagtaat actctatacc ctttttatca tcattaattt ngtaa          1255


<210>  214
<211>  912
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic G7RT-PCR

<400>  214
ccttatttgt tgattctgtg gccatagatt aggatttttt ttcacgaaat tgcttcttga       60

aattacgtga tggattttga ttctgattta tcttgtgatt gttgactcta cagatgcaga      120

tcttcgtcaa gaccctcacc ggaaagacca tcacccttga ggtggaaagc tctgacacca      180

tcgacaacgt caaggccaag atccaggaca aggaaggaat tcccccggat cagcaacgtc      240

tcatcttcgc cggaaagcag ctcgaggacg gccgtaccct cgccgactac aacatccaga      300

aggaatcaac ccttcacctc gtcctccgtc tccgtggtgg catgcagatc ttcgttaaga      360

ccctcaccgg caagactata accctagaag tcgagagctc cgacaccatc gacaacgtca      420

aggctaagat ccaggacaag gagggtatcc ccccagacca gcagaggctg atcttcgccg      480

gcaagcagct cgaggacgga cgtacccttg ctgactacaa catccagaag gagtcaactc      540

tccacttggt gttgcgtctt cgtggtggta tgcagatctt cgtcaagacc cttacgggta      600

agactattac cctcgaggtg gagagctccg acaccattga caatgtgaag gcgaagatcc      660

aggacaagga aggaatccca ccggaccagc agaggcttat ttttgctggc aaacagctag      720

aggatggaag gaccctcgct gactacaaca tccagaagga gtcaactctg cacttggtgt      780

tgcgtcttcg tggggggttt tcaaatgctg ctgatgaagt ggcaactcaa ttactgaatt      840

ttgacctctt gaagcttgcc ggtgatgttg agtctaaccc tggaccaatg gcgcaagtta      900

gcagaatctg ca                                                          912


<210>  215
<211>  889
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic B3 Left Flank


<220>
<221>  misc_feature
<222>  (211)..(212)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  n is a, c, g, or t

<400>  215
ctttagcaac taccttattt gttgattctg tggccataga ttaggatttt tttcacgaaa       60

ttgcttcttg aaattacgtg atggattttg attctgattt atcttgtgat tgttgactct      120

acagatgcag atcttcgtca agaccctcac cggaaagacc atcacccttg aggtggaaag      180

ctctgacacc atcgacaacg tcaaggccaa nntncaggac aaggaaggaa ttcccccgga      240

tcagcaacgt ctcatcttcg ccggaaagca gctcgaggac ggccgtaccc tcgccgacta      300

caacatccag aaggaatcaa cccttcacct cgtcctccgt ctccgtggtg gcatgcagat      360

cttcgttaag accctcaccg gcaagactat aaccctagaa gtcgagagct ccgacaccat      420

cgacaacgtc aaggctaaga tccaggacaa ggagggtatc cccccagacc agcagaggct      480

gatcttcgcc ggcaagcagc tcgaggacgg acgtaccctt gctgactaca acatccagaa      540

ggagtcaact ctccacttgg tgttgcgtct tcgtggtggt atgcagatct tcgtcaagac      600

ccttacgggt aagactatta ccctcgaggt ggagagctcc gacaccattg acaatgtgaa      660

ggcgaagatc caggacaagg aaggaatccc accggaccag cagaggctta tttttgctgg      720

caaacagcta gaggatggaa ggaccctcgc tgactacaac atccagaagg agtcaactct      780

gcacttggtg ttgcgtcttc gtggggggtt ttcaaatgct gctgatgaag tggcaactca      840

attactgaat tttgacctct tgaagcttgc cggtgatgtg agtctaacc                  889


<210>  216
<211>  890
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic B6 Left Flank

<400>  216
ctttagcaac taccttattt gttgattctg tggccataga ttaggatttt tttcacgaaa       60

ttgcttcttg aaattacgtg atggattttg attctgattt atcttgtgat tgttgactct      120

acagatgcag atcttcgtca agaccctcac cggaaagacc atcacccttg aggtggaaag      180

ctctgacacc atcgacaacg tcaaggccca agatccagga caaggaagga attcccccgg      240

atcagcaacg tctcatcttc gccggaaagc agctcgagga cggccgtacc ctcgccgact      300

acaacatcca gaaggaatca acccttcacc tcgtcctccg tctccgtggt ggcatgcaga      360

tcttcgttaa gaccctcacc ggcaagacta taaccctaga agtcgagagc tccgacacca      420

tcgacaacgt caaggctaag atccaggaca aggagggtat ccccccagac cagcagaggc      480

tgatcttcgc cggcaagcag ctcgaggacg gacgtaccct tgctgactac aacatccaga      540

aggagtcaac tctccacttg gtgttgcgtc ttcgtggtgg tatgcagatc ttcgtcaaga      600

cccttacggg taagactatt accctcgagg tggagagctc cgacaccatt gacaatgtga      660

aggcgaagat ccaggacaag gaaggaatcc caccggacca gcagaggctt atttttgctg      720

gcaaacagct agaggatgga aggaccctcg ctgactacaa catccagaag gagtcaactc      780

tgcacttggt gttgcgtctt cgtggggggt tttcaaatgc tgctgatgaa gtggcaactc      840

aattactgaa ttttgacctc ttgaagcttg ccggtgatgt gagtctaacc                 890


<210>  217
<211>  897
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic E9 Left Flank


<220>
<221>  misc_feature
<222>  (887)..(887)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (891)..(891)
<223>  n is a, c, g, or t

<400>  217
ctttagcaac taccttattt gttgattctg tggccataga ttaggatttt tttcacgaaa       60

ttgcttcttg aaattacgtg atggattttg attctgattt atcttgtgat tgttgactct      120

acagatgcag atcttcgtca agaccctcac cggaaagacc atcacccttg aggtggaaag      180

ctctgacacc atcgacaacg tcaaggccaa agatccagga caaggaagga attcccccgg      240

atcagcaacg tctcatcttc gccggaaagc agctcgagga cggccgtacc ctcgccgact      300

acaacatcca gaaggaatca acccttcacc tcgtcctccg tctccgtggt ggcatgcaga      360

tcttcgttaa gaccctcacc ggcaagacta taaccctaga agtcgagagc tccgacacca      420

tcgacaacgt caaggctaag atccaggaca aggagggtat ccccccagac cagcagaggc      480

tgatcttcgc cggcaagcag ctcgaggacg gacgtaccct tgctgactac aacatccaga      540

aggagtcaac tctccacttg gtgttgcgtc ttcgtggtgg tatgcagatc ttcgtcaaga      600

cccttacggg taagactatt accctcgagg tggagagctc cgacaccatt gacaatgtga      660

aggcgaagat ccaggacaag gaaggaatcc caccggacca gcagaggctt atttttgctg      720

gcaaacagct agaggatgga aggaccctcg ctgactacaa catccagaag gagtcaactc      780

tgcacttggt gttgcgtctt cgtggggggt tttcaaatgc tgctgatgaa gtggcaactc      840

aattactgaa ttttgacctc ttgaagcttg ccggtgatgt gagtctnacc ngaccaa         897


<210>  218
<211>  892
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic F9 Left flank


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (891)..(891)
<223>  n is a, c, g, or t

<400>  218
ctntagcaac tncntnattt gttgattctg tggccataga ttaggatttt tttcacgaaa       60

ttgcttcttg aaattacgtg atggattttg attctgattt atcttgtgat tgttgactct      120

acagatgcag atcttcgtca agaccctcac cggaaagacc atcacccttg aggtggaaag      180

ctctgacacc atcgacaacg tcaaggccaa gatccaggac aaggaaggaa ttcccccgga      240

tcagcaacgt ctcatcttcg ccggaaagca gctcgaggac ggccgtaccc tcgccgacta      300

caacatccag aaggaatcaa cccttcacct cgtcctccgt ctccgtggtg gcatgcagat      360

cttcgttaag accctcaccg gcaagactat aaccctagaa gtcgagagct ccgacaccat      420

cgacaacgtc aaggctaaga tccaggacaa ggagggtatc cccccagacc agcagaggct      480

gatcttcgcc ggcaagcagc tcgaggacgg acgtaccctt gctgactaca acatccagaa      540

ggagtcaact ctccacttgg tgttgcgtct tcgtggtggt atgcagatct tcgtcaagac      600

ccttacgggt aagactatta ccctcgaggt ggagagctcc gacaccattg acaatgtgaa      660

ggcgaagatc caggacaagg aaggaatccc accggaccag cagaggctta tttttgctgg      720

caaacagcta gaggatggaa ggaccctcgc tgactacaac atccagaagg agtcaactct      780

gcacttggtg ttgcgtcttc gtggggggtt ttcaaatgct gctgatgaag tggcaactca      840

attactgaat tttgacctct tgaagcttgc cggtgatgtg agtctaaccc ng              892


<210>  219
<211>  889
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic G2 Left flank


<220>
<221>  misc_feature
<222>  (211)..(214)
<223>  n is a, c, g, or t

<400>  219
ctttagcaac taccttattt gttgattctg tggccataga ttaggatttt tttcacgaaa       60

ttgcttcttg aaattacgtg atggattttg attctgattt atcttgtgat tgttgactct      120

acagatgcag atcttcgtca agaccctcac cggaaagacc atcacccttg aggtggaaag      180

ctctgacacc atcgacaacg tcaaggccaa nnnncaggac aaggaaggaa ttcccccgga      240

tcagcaacgt ctcatcttcg ccggaaagca gctcgaggac ggccgtaccc tcgccgacta      300

caacatccag aaggaatcaa cccttcacct cgtcctccgt ctccgtggtg gcatgcagat      360

cttcgttaag accctcaccg gcaagactat aaccctagaa gtcgagagct ccgacaccat      420

cgacaacgtc aaggctaaga tccaggacaa ggagggtatc cccccagacc agcagaggct      480

gatcttcgcc ggcaagcagc tcgaggacgg acgtaccctt gctgactaca acatccagaa      540

ggagtcaact ctccacttgg tgttgcgtct tcgtggtggt atgcagatct tcgtcaagac      600

ccttacgggt aagactatta ccctcgaggt ggagagctcc gacaccattg acaatgtgaa      660

ggcgaagatc caggacaagg aaggaatccc accggaccag cagaggctta tttttgctgg      720

caaacagcta gaggatggaa ggaccctcgc tgactacaac atccagaagg agtcaactct      780

gcacttggtg ttgcgtcttc gtggggggtt ttcaaatgct gctgatgaag tggcaactca      840

attactgaat tttgacctct tgaagcttgc cggtgatgtg agtctaacc                  889


<210>  220
<211>  890
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic G7 Left flank


<220>
<221>  misc_feature
<222>  (211)..(213)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (877)..(879)
<223>  n is a, c, g, or t

<400>  220
ctttagcaac taccttattt gttgattctg tggccataga ttaggatttt tttcacgaaa       60

ttgcttcttg aaattacgtg atggattttg attctgattt atcttgtgat tgttgactct      120

acagatgcag atcttcgtca agaccctcac cggaaagacc atcacccttg aggtggaaag      180

ctctgacacc atcgacaacg tcaaggccaa nnnccaggac aaggaaggaa ttcccccgga      240

tcagcaacgt ctcatcttcg ccggaaagca gctcgaggac ggccgtaccc tcgccgacta      300

caacatccag aaggaatcaa cccttcacct cgtcctccgt ctccgtggtg gcatgcagat      360

cttcgttaag accctcaccg gcaagactat aaccctagaa gtcgagagct ccgacaccat      420

cgacaacgtc aaggctaaga tccaggacaa ggagggtatc cccccagacc agcagaggct      480

gatcttcgcc ggcaagcagc tcgaggacgg acgtaccctt gctgactaca acatccagaa      540

ggagtcaact ctccacttgg tgttgcgtct tcgtggtggt atgcagatct tcgtcaagac      600

ccttacgggt aagactatta ccctcgaggt ggagagctcc gacaccattg acaatgtgaa      660

ggcgaagatc caggacaagg aaggaatccc accggaccag cagaggctta tttttgctgg      720

caaacagcta gaggatggaa ggaccctcgc tgactacaac atccagaagg agtcaactct      780

gcacttggtg ttgcgtcttc gtggggggtt ttcaaatgct gctgatgaag tggcaactca      840

attactgaat tttgacctct tgaagcttgc cggtgannng agtctaaccc                 890


<210>  221
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  221
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  222
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic eCas9

<400>  222
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctggc cgacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctgccctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaaggcccct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  223
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nCas9(D10A)

<400>  223
gacaagaagt acagcatcgg cctggccatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  224
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nCas9(H840A)

<400>  224
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggacgccatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


